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https://www.readbyqxmd.com/read/30019940/tailoring-breast-cancer-therapies-to-reduce-mortality-and-improve-quality-of-life-san-antonio-breast-cancer-symposium-2017-part-2
#1
John R Benson, Ismail Jatoi
The 40th annual San Antonio Breast Cancer Symposium was convened in San Antonio, TX, USA on 5-9 December 2017. More than 7500 clinicians and scientists from around the world participated in the symposium which featured a range of presentations and keynote talks pertaining to breast cancer screening, prevention, loco-regional and systemic therapies. This two-part report highlights a selection of important studies presented at this premier breast cancer event with part 1 focusing on dose-intense radiotherapy, perioperative endocrine therapy, duration of bisphosphonates, immunotherapy, ovarian function suppression and acupuncture...
July 18, 2018: Future Oncology
https://www.readbyqxmd.com/read/30019918/tailoring-breast-cancer-therapies-to-reduce-mortality-and-improve-quality-of-life-san-antonio-breast-cancer-symposium-2017-part-1
#2
John R Benson, Ismail Jatoi
The 40th annual San Antonio Breast Cancer Symposium was convened in San Antonio, Texas on 5-9 December 2017. More than 7500 clinicians and scientists from around the world participated in the symposium which featured a range of presentations and keynote talks pertaining to breast cancer screening, prevention, loco-regional and systemic therapies. This two-part report highlights a selection of important studies presented at this premier breast cancer event with part 1 focusing on dose-intense radiotherapy, perioperative endocrine therapy, duration of bisphosphonates, immunotherapy, ovarian function suppression and acupuncture...
July 18, 2018: Future Oncology
https://www.readbyqxmd.com/read/30019389/mir-335-5p-restores-cisplatin-sensitivity-in-ovarian-cancer-cells-through-targeting-bcl2l2
#3
Ruonan Liu, Hailong Guo, Shifen Lu
OBJECTIVE: Our study was designed to explore the association miR-335-5p and BCL2L2 and to investigate the influence of miR-335-5p/BCL2L2 axis on cisplatin-resistant ovarian cancer cells. METHODS: Microarray analysis was used to determine differentially expressed microRNAs in primary and cisplatin-resistant A2780 cells. Cell function experiments were conducted to investigate the effect of miR-335-5p on the cisplatin sensitivity of A2780 cells. The targeted relationship between BCL2L2 mRNA and miR-335-5p was validated through luciferase assay...
July 17, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/30017187/effect-of-the-interaction-of-metformin-and-bone-morphogenetic-proteins-on-ovarian-steroidogenesis-by-human-granulosa-cells
#4
Nahoko Iwata, Toru Hasegawa, Shiho Fujita, Satoko Nagao, Yasuhiro Nakano, Takahiro Nada, Yuki Nishiyama, Takeshi Hosoya, Fumio Otsuka
In the present study, we studied the effects of metformin and its interactions with the actions of bone morphogenetic proteins (BMPs) on ovarian steroidogenesis. It was revealed that metformin treatment enhanced progesterone production by human granulosa KGN cells and rat primary granulosa cells induced by forskolin and FSH, respectively. In human granulosa cells, it was found that metformin treatment suppressed phosphorylation of Smad1/5/9 activated by BMP-15 compared with that induced by other BMP ligands...
July 12, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/30015900/suppression-of-elk1-inhibits-thyroid-cancer-progression-by-mediating-pten-expression
#5
Yakun Kong, Junjie Yin, Yun Fu, Yufeng Chen, Yanhong Zhou, Xiuqin Geng
ETS‑domain containing protein (Elk1) is reported to be a member of the ETS oncogene family, and promotes tumorigenesis in cancer such as bladder, prostate and ovarian. Nevertheless, the role of Elk1 in thyroid cancer progression remains unclear. In the present study, we aimed to investigate the role and underlying molecular mechanism of Elk1 in thyroid cancer. The results indicated that Elk1 was significantly upregulated in thyroid cancer tissues and cells. We found that loss of Elk1 function obviously induced the expression of early growth response‑1 (Egr‑1) and PTEN, promoted apoptosis and constrained the proliferation of thyroid cancer cells...
July 10, 2018: Oncology Reports
https://www.readbyqxmd.com/read/30015865/microrna%C3%A2-665-suppresses-the-growth-and-migration-of-ovarian-cancer-cells-by-targeting-hoxa10
#6
Jinhui Liu, Yi Jiang, Yicong Wan, Shulin Zhou, Sunita Thapa, Wenjun Cheng
Ovarian cancer is the most lethal gynecological cancer and its metastasis leads to a poor prognosis. The present study was designed to elucidate how microRNA (miR)‑665 regulates the proliferation and migration of ovarian tumor cells. Reverse transcription‑polymerase chain reaction (RT‑PCR) demonstrated that miR‑665 expression was decreased in ovarian cancer tissues. Increased expression of miR‑665 suppressed the growth and migration of ovarian cancer cells, whereas the downregulated expression of miR‑665 led to the opposite results...
July 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30015146/the-use-of-female-estrogenized-goats-as-sexual-stimulator-of-crossbred-dairy-males-subsequently-exposed-to-acyclic-goats-during-two-phases-of-the-anestrous-season
#7
J M Guillen-Muñoz, C A Meza-Herrera, R Rivas-Muñoz, Z Zuñiga-Garcia, G Calderon-Leyva, Miguel Mellado, Francisco G Veliz-Deras
This research evaluated the possible influence of exposure of male goats to estrogenized female goats ("female effect") upon males' sexual behavior [appetitive (ASB) & consummatory (CSB)], as well as the induction of reproductive activity of crossbred dairy female goats exposed to such treated males ("male effect") during the early and deep anestrous periods. Crossbred dairy adult male goats (n = 12; 24-48 mo. old) and 80 anovulatory crossbred dairy adult female goats (34-50 mo. old) were used during two experimental periods: March to April and April to May...
July 7, 2018: Theriogenology
https://www.readbyqxmd.com/read/30014256/low-dosage-of-arsenic-trioxide-as-2-o-3-inhibits-angiogenesis-in-epithelial-ovarian-cancer-without-cell-apoptosis
#8
Dehong Luo, Xiaoyuan Zhang, Renle Du, Wenjuan Gao, Na Luo, Shuangtao Zhao, Yi Li, Rui Chen, Hui Wang, Yonghua Bao, Wancai Yang, Daishun Liu, Wenzhi Shen
Arsenic trioxide (As2 O3 ) induces cell apoptosis and reduces the invasive and metastatic activities in various cancer types. However, the role of As2 O3 in ovarian cancer angiogenesis remains unclear. In this study, we investigated the role of As2 O3 in ovarian cancer angiogenesis and found that a low concentration of As2 O3 causes no effects on epithelial ovarian cancer cell viability or apoptosis. Moreover, we found that As2 O3 -treated epithelial ovarian cancer cells demonstrate a reduced tube formation of endothelial cells in Matrigel...
July 16, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/30012146/a-phase-1-trial-of-autologous-monocytes-stimulated-ex-vivo-with-sylatron-%C3%A2-peginterferon-alfa-2b-and-actimmune-%C3%A2-interferon-gamma-1b-for-intra-peritoneal-administration-in-recurrent-ovarian-cancer
#9
Daniel S Green, Ana T Nunes, Virginia David-Ocampo, Irene B Ekwede, Nicole D Houston, Steven L Highfill, Hanh Khuu, David F Stroncek, Seth M Steinberg, Kathryn C Zoon, Christina M Annunziata
BACKGROUND: Ovarian cancer has no definitive second line therapeutic options, and largely recurs in the peritoneal cavity. Locoregional immune therapy using both interferons and monocytes can be used as a novel approach. Interferons have both cytostatic and cytotoxic properties, while monocytes stimulated with interferons have potent cytotoxic properties. Due to the highly immune suppressive properties of ovarian cancer, ex vivo stimulation of autologous patient monocytes with interferons and infusion of all three agents intraperitoneally (IP) can provide a strong pro-inflammatory environment at the site of disease to kill malignant cells...
July 16, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/30011933/mechanisms-of-tumor-growth-inhibition-by-depletion-of-%C3%AE-glutamylcyclotransferase-ggct-a-novel-molecular-target-for-anticancer-therapy
#10
REVIEW
Susumu Kageyama, Hiromi Ii, Keiko Taniguchi, Shigehisa Kubota, Tetsuya Yoshida, Takahiro Isono, Tokuhiro Chano, Taku Yoshiya, Kosei Ito, Tatsuhiro Yoshiki, Akihiro Kawauchi, Susumu Nakata
γ-Glutamylcyclotransferase (GGCT), which is one of the major enzymes involved in glutathione metabolism, is upregulated in a wide range of cancers-glioma, breast, lung, esophageal, gastric, colorectal, urinary bladder, prostate, cervical, ovarian cancers and osteosarcoma-and promotes cancer progression; its depletion leads to the suppression of proliferation, invasion, and migration of cancer cells. It has been demonstrated that the suppression or inhibition of GGCT has an antitumor effect in cancer-bearing xenograft mice...
July 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/30010735/circulating-testosterone-as-the-hormonal-basis-of-sex-differences-in-athletic-performance
#11
David J Handelsman, Angelica Lindén Hirschberg, Stephane Bermon
Elite athletic competitions have separate male and female events due to men's physical advantages in strength, speed and endurance so that a protected female category with objective entry criteria is required. Prior to puberty, there is no sex difference in circulating testosterone concentrations or athletic performance but from puberty onwards sex difference in athletic performance emerges as circulating testosterone concentrations rise in men because testes produce 30 times more testosterone than before puberty with circulating testosterone exceeding 15-fold those of women at any age...
July 13, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/30009951/sirt2-plays-a-novel-role-on-progesterone-estradiol-and-testosterone-synthesis-via-ppars-lxr%C3%AE-pathways-in-bovine-ovarian-granular-cells
#12
Dejun Xu, Huanshan He, Xiaohan Jiang, Rongmao Hua, Huali Chen, Li Yang, Jianyong Cheng, Jiaxin Duan, Qingwang Li
SIRT2 has been shown to possess NAD+ -dependent deacetylase and desuccinylase enzymatic activities, it also regulates metabolism homeostasis in mammals. Previous data has suggested that resveratrol, a potential activator of Sirtuins, played a stimulation role in steroidogenesis. Unfortunately, to date, the physiological roles of SIRT2 in ovarian granular cells (GCs) are largely unknown. Here, we studied the function and molecular mechanisms of SIRT2 on steroid hormone synthesis in GCs from Qinchuan cattle. Immunohistochemistry and western blotting showed that SIRT2 was expressed not only in GCs and cumulus cells, but also in oocytes and theca cells...
July 12, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/30008853/fbp1-promotes-ovarian-cancer-development-through-the-acceleration-of-cell-cycle-transition-and-metastasis
#13
Xifeng Xiong, Jinli Zhang, Xing Hua, Wenjuan Cao, Shengnan Qin, Libing Dai, Wei Liu, Zhi Zhang, Xiaojian Li, Zhihe Liu
Epithelial ovarian cancer (EOC) is the fifth most common malignancy in women, with a 5-year mortality of >70% in North America. As the symptoms are often not observed until the cancer has spread extensively, few women are diagnosed at an early stage of disease. Large-scale gene expression analyses have identified molecular subtypes within high-grade ovarian cancer with variable survival rates and drug resistance. The understanding of gene expression, the mechanisms underlying cancer processes and drug resistances have facilitated the development of targeted therapies...
August 2018: Oncology Letters
https://www.readbyqxmd.com/read/30007268/prospective-study-to-optimize-care-and-improve-knowledge-on-ovarian-function-and-or-fertility-preservation-in-young-breast-cancer-patients-results-of-the-pilot-phase-of-the-pregnancy-and-fertility-prefer-study
#14
Matteo Lambertini, Valeria Fontana, Claudia Massarotti, Francesca Poggio, Chiara Dellepiane, Giuseppina Iacono, Annalisa Abate, Loredana Miglietta, Chiara Ferreccio, Maria Carolina Pescio, Benedetta Conte, Eva Blondeaux, Claudia Bighin, Alessia D'Alonzo, Marina Vaglica, Elisa Zanardi, Francesco Boccardo, Alberto Ballestrero, Paola Anserini, Lucia Del Mastro
BACKGROUND: Despite the availability of different strategies for ovarian function and/or fertility preservation in young breast cancer patients candidates for chemotherapy, limited data are available on patients' actual need of these options. PATIENTS AND METHODS: The PREFER study is a prospective cohort study including premenopausal women with newly diagnosed early stage breast cancer between the age of 18 and 45 years and candidates for chemotherapy. The study aimed to investigate patients' preferences and their choices of the different available strategies for ovarian function and/or fertility preservation (i...
June 22, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/30003858/the-drug-combination-of-sb202190-and-sp600125-significantly-inhibit-the-growth-and-metastasis-of-olaparib-resistant-ovarian-cancer-cell
#15
Xinyan Chen, Yumei Chen, Xueyan Lin, Shan Su, Xiaoman Hou, Qian Zhang, Yongjie Tian
BACKGROUND & OBJECTIVE: Many targeted ovarian cancer patients are resistant to olaparib treatment. Here we seek to understand the underlying molecular events and search for potential combinational therapeutics to surmount the intrinsic olaparib resistance in human ovarian cancer. METHODS: The cytotoxicity was determined by the MTT assay and cell viability was measured using Cell Counting Kit-8 (CCK-8). Protein expressions of ERK, P38, JNK, ERK5, LC3, N-CADHERIN, α-SMA were determined by western blotting...
July 12, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/30003749/anticancer-effects-of-rosmarinic-acid-in-ovcar-3-ovarian-cancer-cells-are-mediated-via-induction-of-apoptosis-suppression-of-cell-migration-and-modulation-of-lncrna-malat-1-expression
#16
Yan Zhang, Min Hu, Liu Liu, Xiao-Ling Cheng, Jing Cai, Jian Zhou, Tao Wang
PURPOSE: The main objective of the present research work was to study the anticancer properties of rosmarinic acid in OVCAR-3 human ovarian cancer cells and also to evaluate its effects on apoptosis induction, cancer cell migration and modulation of lncRNA MALAT-1 expression. METHODS: MTT assay was used to study the effects of the agent on OVCAR-3 cell viability, while inverted phase contrast microscopy and fluorescence microscopy were used to study the effects on cell morphology...
May 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/30001741/sex-differences-in-the-traumatic-stress-response-the-role-of-adult-gonadal-hormones
#17
Apryl E Pooley, Rebecca C Benjamin, Susheela Sreedhar, Andrew L Eagle, Alfred J Robison, Michelle S Mazei-Robison, S Marc Breedlove, Cynthia L Jordan
BACKGROUND: Our previous study revealed that adult female rats respond differently to trauma than adult males, recapitulating sex differences in symptoms of post-traumatic stress disorder (PTSD) exhibited by women and men. Here, we asked two questions: does the female phenotype depend on (1) social housing condition and/or (2) circulating gonadal hormones? METHODS: For the first study, the effects of single prolonged stress (SPS) were compared for females singly or pair-housed...
July 13, 2018: Biology of Sex Differences
https://www.readbyqxmd.com/read/29997615/chromatin-binding-of-c-rel-and-p65-is-not-limiting-for-macrophage-il12b-transcription-during-immediate-suppression-by-ovarian-carcinoma-ascites
#18
Annika Unger, Florian Finkernagel, Nathalie Hoffmann, Felix Neuhaus, Barbara Joos, Andrea Nist, Thorsten Stiewe, Alexander Visekruna, Uwe Wagner, Silke Reinartz, Sabine Müller-Brüsselbach, Rolf Müller, Till Adhikary
Tumors frequently exploit homeostatic mechanisms that suppress expression of IL-12, a central mediator of inflammatory and anti-tumor responses. The p40 subunit of the IL-12 heterodimer, encoded by IL12B , is limiting for these functions. Ovarian carcinoma patients frequently produce ascites which exerts immunosuppression by means of soluble factors. The NFκB pathway is necessary for transcription of IL12B , which is not expressed in macrophages freshly isolated from ascites. This raises the possibility that ascites prevents IL12B expression by perturbing NFκB binding to chromatin...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29995717/polycystic-ovary-syndrome
#19
Ricardo Azziz
Polycystic ovary syndrome (PCOS) is a highly prevalent disorder, representing the single most common endocrine-metabolic disorder in reproductive-aged women. Currently there are four recognized phenotypes of PCOS: 1) hyperandrogenism+oligo-anovulation+polycystic ovarian morphology; 2) hyperandrogenism+oligo-anovulation; 3) hyperandrogenism+polycystic ovarian morphology; and 4) oligo-anovulation+polycystic ovarian morphology, each with different long-term health and metabolic implications. Clinicians should clearly denote a patient's phenotype when making the diagnosis of PCOS...
July 10, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29990836/microrna-298-represses-hepatocellular-carcinoma-progression-by-inhibiting-ctnnd1-mediated-wnt-%C3%AE-catenin-signaling
#20
Ningjia Cao, Liang Mu, Wei Yang, Li Liu, Liang Liang, Hong Zhang
MicroRNAs (miRNAs) are solid factors involved in the initiation and progression of hepatocellular carcinoma (HCC). Recently, miR-298 is recognized as a cancer-associated miRNA in breast, gastric and ovarian cancer. However, the functional role of miR-298 and its underlying mechanism are rarely reported in HCC. Herein, we found that the expression of miR-298 was down-regulated in HCC tissues and cell lines. The in vitro experiments showed that miR-298 overexpression inhibited cell proliferation, migration and invasion, and induced G1 arrest and apoptosis of HCC cells...
July 2, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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