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ovarian suppression

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https://www.readbyqxmd.com/read/29050320/epigenetic-regulation-of-interleukin-8-expression-by-class-i-hdac-and-cbp-in-ovarian-cancer-cells
#1
Himavanth R Gatla, Yue Zou, Mohammad M Uddin, Ivana Vancurova
Although inhibitors of epigenetic regulators have been effective in the treatment of cutaneous T cell lymphoma (CTCL) and other hematopoietic malignancies, they have been less effective in solid tumors, including ovarian cancer (OC). We have previously shown that inhibition of histone deacetylase (HDAC) activity induces expression of the pro-inflammatory and pro-angiogenic chemokine interleukin-8 (CXCL8, IL-8) in OC cells, resulting in their increased survival and proliferation. Here, we show that in addition to ovarian cancer SKOV3, OVCAR3, and CAOV3 cells, HDAC inhibition induces the CXCL8 expression in HeLa cells, but not in CTCL Hut-78 cells...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050266/physapubescin-b-inhibits-tumorgenesis-and-circumvents-taxol-resistance-of-ovarian-cancer-cells-through-stat3-signaling
#2
Xiaofeng Zhao, Lu Huang, Wanwan Xu, Xiaoyan Chen, Yan Shen, Wenjie Zeng, Xiao Chen
Ovarian cancer is the most lethal gynaecological malignancy. Recurrence and subsequent resistance to chemotherapy have become major obstacles to treating these diseases. In the present study, we showed that a natural withanolide isolated from the plant Physalis pubescens L. (Solanaceae), Physapubescin B, exhibited potent anti-tumor activity against ovarian cancer cells. Physapubescin B promoted apoptosis, induced cell-cycle arrest and inhibited invasion of ES-2 and A2780 cells. Physapubescin B treatment also resulted in suppression of the transcriptional activity of STAT3, an oncogenic transcription factor activated in many human malignancies including ovarian cancer, through disturbing the dimerization of STAT3, and thereby inhibited the nuclear translocation of Tyr705/Ser727-phosphorylated STAT3...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049989/the-usp7-inhibitor-p5091-induces-cell-death-in-ovarian-cancers-with-different-p53-status
#3
Mengying Wang, Yayun Zhang, Taishu Wang, Jinrui Zhang, Zhu Zhou, Yan Sun, Shanshan Wang, Yulin Shi, Xuelin Luan, Yingqiu Zhang, Yifei Wang, Yang Wang, Zhongwen Zou, Lan Kang, Han Liu
BACKGROUND/AIMS: Ovarian cancer is often diagnosed at later stages with poor prognosis. Recent studies have associated the expression of deubiquitylase USP7 with the survival of ovarian cancers. Being a cysteine protease, USP7 could become a target for pharmacological intervention. Therefore, in this study, we assessed the influence of its inhibitor P5091 on ovarian cancer cells. METHODS: Ovarian cancer cells were treated with P5091, and cell proliferation was measured with MTT assay; cell morphology was inspected under a phase-contrast microscope; cell cycle and cell death were examined by flow cytometry...
October 19, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29045963/-tumor-derived-igg-suppress-the-proliferation-of-t-cells-in-cord-blood
#4
E Y Liu, J F Liu, W W Shao, L Xiao, G H Li, X H Chang, X Y Qiu
OBJECTIVE: To explore the function of tumor derived IgG (tIgG) and whether the tIgG can inhibit T cells activity. METHODS: The tIgG was purified from ovarian cancer tissue. The cord blood monocyte cells (CBMC) and cord blood lymphocyte (CBL) were isolate from human umbilical cord blood. The CBMC and CBL were stimulated with phytohaemagg lutinin (PHA) in order to let the CBMC and CBL in the state of proliferation. Carboxyfluorescein succinimidyl amino ester (CFSE) was cultured with CBMC and CBL...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29041009/fcgr2a-and-fcgr3a-genotypes-correlate-with-farletuzumab-response-in-patients-with-first-relapsed-ovarian-cancer-exhibiting-low-ca125
#5
Wenquan Wang, Elizabeth B Somers, Erin N Ross, J Bradford Kline, Daniel J O'Shannessy, Charles Schweizer, Susan Weil, Luigi Grasso, Nicholas C Nicolaides
Farletuzumab is a humanized monoclonal antibody that binds to folate receptor alpha and elicits an anti-tumor response via immune effector activity. Recent studies from a global phase 3 trial in ovarian cancer patients treated with carboplatin/taxane plus farletuzumab found that the tumor-produced CA125 protein can suppress farletuzumab function via perturbing its engagement to the activating Fc-γ receptors CD32a (FCGR2A) and CD16a (FCGR3A). Previous reports have indicated that naturally occurring polymorphisms in both of these receptors may play a role in their ability to engage therapeutic antibodies and elicit an optimal immune response via antibody-dependent cellular cytotoxicity (ADCC)...
October 18, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29039573/antitumor-effects-of-baicalin-on-ovarian-cancer-cells-through-induction-of-cell-apoptosis-and-inhibition-of-cell-migration-in%C3%A2-vitro
#6
Chen Gao, Yinglu Zhou, Huatao Li, Xia Cong, Zhongling Jiang, Xin Wang, Rongfeng Cao, Wenru Tian
Baicalin, an active flavone isolated from Scutellaria baicalensis Georgi, has been demonstrated to induce various beneficial biochemical effects such as anti‑inflammatory, anti‑viral, and antitumor effects. However, the antitumor mechanism of baicalin is not well understood. In the present study, baicalin was demonstrated to inhibit the viability and migration of a widely used ovarian cancer cell line, A2780, in a dose‑dependent manner. MTT assays revealed that cell viability significantly decreased in ovarian cancer cells treated with baicalin compared with untreated cells, without effect on normal ovarian cells...
October 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039517/microrna%C3%A2-455-inhibits-cell-proliferation-and-invasion-of-epithelial-ovarian-cancer-by-directly-targeting-notch1
#7
Lixia Xu, Haiyan Li, Lei Su, Qian Lu, Zhenfeng Liu
Ovarian cancer (OC) is the fifth leading cause of cancer‑associated mortality among women in developed countries. Numerous microRNAs are aberrantly expressed in epithelial (E) OC, and are involved in EOC formation and progression. As such, microRNAs may be investigated as diagnostic and prognostic molecular biomarkers, and therapeutic targets for patients with EOC. For instance, microRNA‑455 (miR‑455) is abnormally expressed in various types of human cancer. However, details on the expression level, biological roles and underlying mechanism of miR‑455 in EOC remain unclear...
October 13, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29024968/iron-suppresses-ovarian-granulosa-cell-proliferation-and-arrests-cell-cycle-through-regulating-p38-mapk-p53-p21-pathway
#8
Mei-Jou Chen, Chia-Hong Chou, Chia-Tung Shun, Tsui-Lien Mao, Wen-Fen Wen, Chin-Der Chen, Shee-Uan Chen, Yu-Shih Yang, Hong-Nerng Ho
Iron is an essential nutrient that may exert toxic effects when it accumulates in tissues. Little is known regarding its effects on gonadal function. Both Fe2+ and Fe3+ could be released from iron deposition. We employed mouse non-luteinized granulosa cell for in vitro studies and human ovarian tissues for Prussian blue and immunohistochemical staining to identify the iron deposition and effect in vivo. After treatment with FeSO4-7H2O or FeCl3 in granulosa cell cultured with follicle stimulating hormone (FSH) for 48 hours, we found that Fe2+ significantly suppressed FSH-induced granulosa cell proliferation and arrested the cell cycle at the G2/M phase by cell proliferation assay and flow cytometry...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024053/direct-effect-of-pholyphenol-rich-plants-rooibos-and-ginkgo-on-porcine-ovarian-cell-functions
#9
A Štochmaľová, A Kádasi, R Alexa, M Bauer, A H Harrath, A V Sirotkin
The polyphenol-rich plants rooibos and ginkgo are widely used in folk medicine and in preparation of foods and drinks, but their effect on reproduction has not been properly studied yet. The aim of our in vitro experiments was to examine the possible direct effect of rooibos and ginkgo on the basic ovarian cell functions-proliferation, apoptosis and release of hormones progesterone (P4) and leptin (L). Porcine ovarian granulosa cells were cultured in the presence of rooibos or ginkgo extract (0, 1, 10 and 100 μg/ml of medium)...
October 11, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29024042/pro-inflammatory-m1-macrophage-enhances-metastatic-potential-of-ovarian-cancer-cells-through-nf-%C3%AE%C2%BAb-activation
#10
Untack Cho, Boyun Kim, Soochi Kim, Youngjin Han, Yong Sang Song
Obesity is a serious health problem and critically related to poor prognosis in cancer, presumably through induction of chronic inflammation. The major culprit for cancer progression in obesity is presumed to be macrophages. Accumulation of macrophages in adipose tissue due to obesity induced chronic inflammation has been observed. However, obesity-induced macrophage accumulation related to ovarian cancer progression remains unclear. So, the role of macrophage in cancer progression is needed to be further defined for therapeutic intervention...
October 12, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29023465/in-vitro-effects-of-apixaban-on-5-different-cancer-cell-lines
#11
Luigina Guasti, Alessandro Squizzato, Paola Moretto, Davide Vigetti, Walter Ageno, Francesco Dentali, Andrea M Maresca, Leonardo Campiotti, Anna M Grandi, Alberto Passi
BACKGROUND: Cancer is associated with hypercoagulability. However, several data suggest that anticoagulant drugs may have an effect on tumor development and progression mediated by both coagulation dependent processes and non-coagulation dependent processes. Therefore, we investigated the in vitro effects of Apixaban on cell proliferation, mortality, cell migration, gene expression and matrix metalloproteinase in 5 different cancer cell lines. METHODS: The following cancer cell lines, and 2 normal fibroblast cultures (lung and dermal fibroblasts), were studied: OVCAR3 (ovarian cancer), MDA MB 231 (breast cancer), CaCO-2 (colon cancer), LNCaP (prostate cancer) and U937 (histiocytic lymphoma)...
2017: PloS One
https://www.readbyqxmd.com/read/28991639/haemanthamine-alters-sodium-butyrate-induced-histone-acetylation-p21-waf1-cip1-expression-chk1-and-chk2-activation-and-leads-to-increased-growth-inhibition-and-death-in-a2780-ovarian-cancer-cells
#12
Martina Seifrtová, Radim Havelek, Lucie Cahlíková, Daniela Hulcová, Naděžda Mazánková, Martina Řezáčová
BACKGROUND: Haemanthamine (HA) and sodium butyrate (NaB) are promising candidates for chemotherapy as a treatment for cancer. PURPOSE: We aimed to determine the anticancer potential of HA and NaB, alone and in combination, in A2780 ovarian cancer cells and concurrently investigated anticancer potential in contrast to non-cancer human MRC-5 fibroblasts. METHODS: Antiproliferative effects were determined by WST-1 assay and by Trypan blue exclusion staining...
November 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28991261/esrp1-is-overexpressed-in-ovarian-cancer-and-promotes-switching-from-mesenchymal-to-epithelial-phenotype-in-ovarian-cancer-cells
#13
H M Jeong, J Han, S H Lee, H-J Park, H J Lee, J-S Choi, Y M Lee, Y-L Choi, Y K Shin, M J Kwon
Epithelial splicing regulatory protein 1 (ESRP1) and 2 (ESRP2), epithelial cell-specific regulators of alternative splicing, are downregulated during the epithelial-mesenchymal transition (EMT). These factors have roles in tumor progression and metastasis in some cancers; however, their expression and function in ovarian cancer (OC) remain unclear. We found that ESRP1 and ESRP2 mRNAs were expressed at higher levels in OC cells than in immortalized ovarian surface epithelial (IOSE) cells, and confirmed their overexpression in OC tissues at the protein level...
October 9, 2017: Oncogenesis
https://www.readbyqxmd.com/read/28990249/berberine-inhibits-the-chemotherapy-induced-repopulation-by-suppressing-the-arachidonic-acid-metabolic-pathway-and-phosphorylation-of-fak-in-ovarian-cancer
#14
Yawei Zhao, Lianzhi Cui, Yue Pan, Dan Shao, Xiao Zheng, Fan Zhang, Hansi Zhang, Kan He, Li Chen
OBJECTIVES: Cytotoxic chemotherapy is an effective and traditional treatment of ovarian cancer. However, chemotherapy-induced apoptosis may also trigger and ultimately accelerate the repopulation of the small number of adjacent surviving cells. This study mainly focused on the tumour cell repopulation caused by chemotherapy in ovarian cancer and the adjunctive/synergistic effect of Berberine on the prevention of tumour repopulation. MATERIALS AND METHODS: The transwell system was used to mimic the co-culture of surviving ovarian cancer cells in the microenvironment of cytotoxic chemotherapy-treated dying cells...
October 8, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28990044/microrna%C3%A2-320-targets-mitogen%C3%A2-activated-protein-kinase-1-to-inhibit-cell-proliferation-and-invasion-in-epithelial-ovarian-cancer
#15
Yongqian Xu, Jian Hu, Chunxia Zhang, Yuanyuan Liu
Ovarian cancer is the second most frequently occurring cancer and the most fatal gynecological malignancy of all gynecological cancers worldwide. MicroRNAs (miR) have been reported to be downregulated or upregulated in a variety of human malignancies, and involved in the formation and progression of the majority of human cancers, including epithelial ovarian cancer (EOC). miR‑320 has been identified as a tumor suppressor in multiple human cancers. However, the expression levels, biological role and underlying mechanisms of miR‑320 in EOC remain to be elucidated...
September 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28984384/the-role-of-the-long-non-coding-rna-tdrg1-in-epithelial-ovarian-carcinoma-tumorigenesis-and-progression-through-mir-93-rhoc-pathway
#16
Shuo Chen, Li-Li Wang, Kai-Xuan Sun, Yin-Ling Xiu, Zhi-Hong Zong, Xi Chen, Yang Zhao
As one of the most frequently diagnosed cancers in women, the development and progression of epithelial ovarian carcinoma (EOC) remains an open area of research. The role of long non-coding RNAs (lncRNAs) in EOC is an emerging field of study. We found that LncRNA TDRG1 (human testis development-related gene 1) was highly expressed in EOC tissues than in normal ovarian tissues, and expression differed significantly with differentiation. LncRNA TDRG1 downregulation suppressed EOC cell proliferation, migration, and invasion, while its overexpression had the opposite effect...
October 6, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28982841/adjuvant-endocrine-therapy-for-hormone-positive-breast-cancer-focusing-on-ovarian-suppression-and-extended-treatment-an-update
#17
REVIEW
Daniel Glassman, Sue Hignett, Shazza Rehman, Richard Linforth, Mohamed Salhab
The benefits of five years of adjuvant endocrine therapy for oestrogen receptor (ER)-positive early breast cancer are well established. However, recent evidence suggests that extended endocrine treatment and ovarian suppression in selected groups of patients have significant advantages. In this article, we review the current evidence for adjuvant endocrine therapy in breast cancer with focus on extended adjuvant endocrine therapy and ovarian suppression, and also highlight the advantages and disadvantages of these therapeutic strategies...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28981692/carboxylesterase-precursor-est-1-mediated-the-fungicide-jinggangmycin-suppressed-reproduction-of-sogatella-furcifera-hemiptera-delphacidae
#18
Lin-Quan Ge, Bo Huang, Yi-Ping Jiang, Hao-Tian Gu, Ting Xia, Guo-Qing Yang, Fang Liu, Jin-Cai Wu
The jinggangmycin (JGM) is a widely used fungicide for controlling the rice sheath blight, Rhizoctonia solani, in China. Previous experiments under lab conditions showed that JGM foliar spray suppressed Sogatella furcifera (Horvath) reproduction. However, the molecular mechanisms of JGM-driven changes in S. furcifera reproduction are unclear. Therefore, we selected carboxylesterase precursor (EST-1) as a target gene for silencing by RNAi based on gene expression profiles. The present results demonstrated that JGM and control + dsSfEST-1 treatments significantly reduced the number of eggs laid (down by 58% and 54%, respectively), oviposition period (down by 57% and 38%, respectively), and longevity (down by 32% and 38%, respectively) in adult females compared with untreated controls, while no pronounced differences in the preoviposition period were observed...
July 19, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28981116/mir-181a-increases-foxo1-acetylation-and-promotes-granulosa-cell-apoptosis-via-sirt1-downregulation
#19
Mei Zhang, Qun Zhang, Yali Hu, Lu Xu, Yue Jiang, Chunxue Zhang, Lijun Ding, Ruiwei Jiang, Jianxin Sun, Haixiang Sun, Guijun Yan
Oxidative stress impairs follicular development by inducing granulosa cell (GC) apoptosis, which involves enhancement of the transcriptional activity of the pro-apoptotic factor Forkhead box O1 (FoxO1). However, the mechanism by which oxidative stress promotes FoxO1 activity is still unclear. Here, we found that miR-181a was upregulated in hydrogen peroxide (H2O2)-treated GCs and a 3-nitropropionic acid (NP)-induced in vivo model of ovarian oxidative stress. miR-181a overexpression promoted GC apoptosis, whereas knockdown of endogenous miR-181a blocked H2O2-induced cell apoptosis...
October 5, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28979684/lncrna-ewsat1-promotes-ovarian-cancer-progression-through-targeting-mir-330-5p-expression
#20
Xin Fu, Li Zhang, Li Dan, Ke Wang, Yue Xu
Ovarian cancer ranks as the fifth common tumour in women and is the leading cause of cancer-related death among the women. Long non-coding RNAs (lncRNAs) play crucial roles in the development of tumors. However, the expression and the role of EWSAT1 in ovarian tumor are still unknown. In our study, we found the expression of EWSAT1 was upregulated in ovarian cancer cell lines and samples. Ecoptic expression of EWSAT1 suppressed miR-330-5p expression in ovarian cancer cell. In addition, the expression of miR-330-5p was downregulated in ovarian cancer cell lines and samples...
2017: American Journal of Translational Research
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