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https://www.readbyqxmd.com/read/28642790/therapeutic-outcomes-of-patients-with-multifocal-papillary-thyroid-microcarcinomas-and-larger-tumors
#1
Soh-Ching Ng, Sheng-Fong Kuo, Szu-Tah Chen, Chuen Hsueh, Bie-Yu Huang, Jen-Der Lin
A retrospective review of 626 patients with multifocal papillary thyroid carcinoma (PTC) including 147 patients (23.5%) with multifocal papillary thyroid microcarcinoma (PTMC) from a total of 2,536 patients with PTC who visited the Chang Gung Medical Center in Linkou, Taiwan, was performed. A comparison of the clinical features between 626 multifocal and 1,910 solitary PTC cases showed that patients in the multifocal PTC group were older and had a smaller mean tumor size, a more advanced tumor-node-metastasis (TNM) stage, and a higher percentage of nonremission status compared to patients in the solitary PTC group...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28635215/-retrospective-comparison-of-screening-criteria-for-active-surveillance-for-papillary-thyroid-microcarcinoma
#2
K Qian, T Q Sun, K Guo, X K Zheng, D S Li, W W Wei, Y Wu, Q H Ji, Z Y Wang
Objective: To investigate the rationality of management of active surveillance for papillary thyroid microcarcinoma (PTMC) and the main indications for active surveillance for PTMC. Methods: In this study, two criteria were used to evaluate patients with PTMC: low-risk PTMC conditions defined by Kuma hospital and Chinese Association of Thyroid Oncology (CATO) consensus on PTMC management of active surveillance. The patients had received surgical treatment. Clinicopathological characteristics and prognosis of the patients in different groups were compared...
June 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28635214/-clinicopathological-characteristics-of-papillary-thyroid-microcarcinoma-and-risk-factors-for-central-lymph-node-metastasis
#3
Y L Wu, J M Sun, J J Zhang, Q X Cui, W H Zheng, X R Li
Objective: To analyze the clinicopathological characteristics of papillary thyroid microcarcinoma (PTMC) and risk factors for central lymph node metastasis(CLNM) in PTMC. Methods: The data of 900 patients with PTMC initially treated in our hospital from January 2004 to December 2015 were retrospectively analyzed. Chi-square test and Logistic regression analysis were performed to determine the risk factors for CLNM. Results: CLNM affected 162 (22.9%) of 707 patients treated with central lymph node dissection...
June 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28621699/diagnostic-value-of-single-source-dual-energy-spectral-computed-tomography-for-papillary-thyroid-microcarcinomas
#4
Lin Li, Yong Wang, De-Hong Luo, Yan-Feng Zhao, Meng Lin, Wei Guo, Lei Hu, Chun-Wu Zhou, Xin-Ming Zhao
BACKGROUND: Ultrasound (US) and computed tomography (CT) are common diagnostic imaging methods for detecting and diagnosing papillary thyroid microcarcinoma (PTMC). However, single-source dual-energy spectral computed tomography (spectral CT) reduces beam hardening artefacts and optimizes contrast, which may add value in detecting PTMC. OBJECTIVE: To investigate values of applying single-source dual-energy spectral CT for diagnosing PTMCs, in comparison with high frequency ultrasound and conventional polychromatic images...
June 10, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/28614984/tert-promoter-mutations-were-not-found-in-papillary-thyroid-microcarcinomas-that-showed-disease-progression-on-active-surveillance
#5
Tomonori Yabuta, Michiko Matsuse, Mitsuyoshi Hirokawa, Shunichi Yamashita, Norisato Mitsutake, Akira Miyauchi
BACKGROUND: Papillary thyroid carcinoma (PTC) generally has an indolent course, and non-operative management is acknowledged for papillary thyroid microcarcinoma (PTMC). However, some PTMCs progress and we cannot predict future progression at their presentation. BRAF and TERT promoter mutations were recently reported to be associated with poor outcomes of PTC. Here we sought to determine whether these mutations are associated with the progression of PTMCs, toward the goal of predicting progression/nonprogression...
June 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28600731/lack-of-efficacy-of-radioiodine-remnant-ablation-for-papillary-thyroid-microcarcinoma-verification-using-inverse-probability-of-treatment-weighting
#6
Hyemi Kwon, Min Ji Jeon, Won Gu Kim, Suyeon Park, Mijin Kim, Tae Yong Kim, Minkyu Han, Dong Eun Song, Tae-Yon Sung, Jong Ho Yoon, Suck Joon Hong, Jin-Sook Ryu, Young Kee Shong, Won Bae Kim
BACKGROUND: Most of the increase in thyroid cancer in recent decades has been due to papillary thyroid microcarcinoma (PTMC). We evaluated the efficacy of radioiodine remnant ablation (RRA) in patients with PTMC. METHODS: This historical cohort study included 1932 PTMC patients without lateral cervical lymph node (LN) or distant metastasis who underwent total thyroidectomy (TT) during the median 8.3 years of follow-up. The clinical outcomes of patients with or without RRA were compared using weighted logistic regression models with the inverse probability of treatment weighting (IPTW) method and considering risk factors, including age, sex, primary tumor size, extrathyroidal extension, multifocality, and central cervical LN metastasis...
June 9, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28550398/association-of-tumor-size-and-focality-with-recurrence-persistence-in-papillary-thyroid-cancer-patients-treated-with-total-thyroidectomy-along-with-radioactive-iodine-ablation-and-tsh-suppression
#7
Misbah Khan, Aamir Ali Syed, Amina Iqbal Khan, Syed Raza Hussain, Namra Urooj
Locoregional recurrence is common in papillary thyroid cancer PTC and an optimal surgical treatment with respect to the multifocal nature of the disease stays controversial. It is a retrospective analytical study design. 209 diagnosed PTCs managed at our institute were grouped into macro-PTC with a size of dominant focus >1 cm (unifocal n = 106 and multifocal n = 64) and micro-PTMC if size of all foci was <1 cm; (unifocal n = 16 and multifocal PTMC n = 23). The primary endpoint is recurrence and tumor free survival in each of the four groups...
May 26, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28535653/-clinical-pathological-characteristics-of-resectable-papillary-thyroid-microcarcinoma
#8
C L Shi, Y Guo, Y C Lyu, Z A B Y S Nanding, W C Gao, T F Shi, H D Qin, S Y Liu
Objective: To investigate the difference of prognostic factors and recurrence rates between papillary thyroid microcarcinoma (PTMC) and lager papillary thyroid carcinoma (PTC) and analyze the clinical pathological characteristics of PTMC suitable for surgery. Methods: A retrospective analysis on the clinicopathological features, expression level of of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) V600E gene mutation and pigment epithelium-derived factor (PEDF), and postoperative follow-up results of the 251 PTC patients who underwent surgical treatment from October 2011 to October 2013, including 169 cases with PTMC and 82 with lager PTC (Tumor diameter>1 cm)...
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28534700/risk-factors-for-lymph-node-metastasis-lnm-in-patients-with-papillary-thyroid-microcarcinoma-ptmc-role-of-preoperative-ultrasound
#9
Cheng Zhao, Wenbin Jiang, Yuxiu Gao, Weidong Niu, Xiaojuan Zhang, Lei Xin
Objective This study aimed to investigate the risk factors and clinical value of lymph node metastasis (LNM) and missed central lymph node metastasis (CLNM) using preoperative ultrasound (US) in patients with papillary thyroid microcarcinoma (PTMC). Methods This retrospective study included 521 patients who underwent thyroidectomy for confirmed PTMC based on a final histological examination between January 2014 and June 2015. Based on the presence of LNM, 521 cases were divided into two groups: metastasis (218) and non-metastasis (303)...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28513128/clinical-features-of-recently-diagnosed-papillary-thyroid-carcinoma-in-elderly-patients-aged-65-and-older-based-on-10-years-of-sonographic-experience-at-a-single-institution-in-korea
#10
Eun Sil Kim, Younghen Lee, Hyungsuk Seo, Gil Soo Son, Soon Young Kwon, Young-Sik Kim, Ji-A Seo, Nan Hee Kim, Sang-Il Suh, Inseon Ryoo, Sung-Hye You
Purpose: The aim of this study was to assess the characteristics of papillary thyroid carcinoma (PTC) in patients aged 65 and older in order to predict postoperative recurrence based on the results of ultrasonographic surveillance. Methods: Among 1,494 patients (200 male and 1,294 female; mean age, 46.6±11.3 years) who underwent surgery for thyroid cancer at our institution between 2006 and 2015, we retrospectively enrolled 150 PTC patients (29 male and 121 female; mean age, 69...
April 13, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28506411/partial-thyroidectomy-for-papillary-thyroid-microcarcinoma-is-completion-total-thyroidectomy-indicated
#11
C Dobrinja, M Pastoricchio, M Troian, F Da Canal, S Bernardi, B Fabris, N de Manzini
AIM: Papillary thyroid microcarcinoma (PTMC) is increasing in incidence. Despite its excellent clinical outcomes, there is still debate regarding which surgical approach is more appropriate for PTMC, procedures including hemithyroidectomy (HT), total thyroidectomy (TT), and completion thyroidectomy (CT) after initial HT and histopathologic examination confirming a PTMC. Here we report our experience in the surgical management of PTMC. METHODS: We conducted a retrospective evaluation of all patients who received a postoperative diagnosis of PTMC between January 2001 and January 2016...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28500312/total-tumour-diameter-is-superior-to-unifocal-diameter-as-a-predictor-of-papillary-thyroid-microcarcinoma-prognosis
#12
Chunping Liu, Shuntao Wang, Wen Zeng, Yawen Guo, Zeming Liu, Tao Huang
The current American Joint Committee (AJCC) on Cancer TNM classification does not describe the treatment of multifocal papillary thyroid microcarcinomas (PTMCs) with a total tumour diameter (TTD) >1 cm. Herein, we investigated this PTMC subgroup in terms of extrathyroidal extension (ETE), local infiltration, central lymph node metastasis (LNM), and prognosis. Consecutive patients (n = 1102) were identified and the proportions of LNM, ETE, and local infiltration were similar between PTCs with a unifocal tumour diameter >1 cm and ≤2 cm and PTMCs with a multifocal TTD >1 cm and ≤2 cm...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28476312/identification-of-risk-factors-of-central-lymph-node-metastasis-and-evaluation-of-the-effect-of-prophylactic-central-neck-dissection-on-migration-of-staging-and-risk-stratification-in-patients-with-clinically-node-negative-papillary-thyroid-microcarcinoma
#13
Jiru Yuan, Jinghua Li, Xiaoyi Chen, Xiaodong Lin, Jialin Du, Gang Zhao, Zhengbo Chen, Zeyu Wu
OBJECTIVE: The first aim of this study was to explore the risk factors that were associated with central lymph node metastasis (CLNM) in patients with clinically node-negative papillary thyroid microcarcinoma (cN0 PTMC) after prophylactic central neck dissection (PCND). The second aim was to evaluate the influence of PCND on migration of TNM staging and risk stratification (RS) in patients with cN0 PTMC. METHODS: A total of 295 cN0 PTMC patients who underwent thyroidectomy with PCND in the Department of General Surgery at Guangdong General Hospital between March 2014 to December 2015 were assessed retrospectively...
May 2, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28463605/comparison-of-poly-l-lactide-co-%C3%AE%C2%B5-caprolactone-and-poly-trimethylene-carbonate-membranes-for-urethral-regeneration-an-in-vitro-and-in-vivo-study
#14
Reetta Sartoneva, Panu Nordback, Suvi Haimi, Dirk W Grijpma, Kalle Lehto, Rooney Niall, Riitta Seppänen-Kaijansinkko Md Dds PhD, Susanna Miettinen, Tuija Lahdes-Vasama
Urethral defects are normally reconstructed using patient's own genital tissue; however, in severe cases, additional grafts are needed. We studied the suitability of poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(trimethylene carbonate) (PTMC) membranes for urethral reconstruction in vivo. Further, the compatibility of the materials was evaluated in vitro with human urothelial cells (hUC). The attachment and viability of hUCs and the expression of different urothelial cell markers (Cytokeratin 7, 8, 19 and Uroplakin Ia, Ib and III) were studied after in vitro cell culture on PLCL and PTMC...
May 2, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28460768/case-series-difficult-ptmc-using-novel-technique-of-veno-arterial-looping
#15
Veena Nanjappa, K S Sadanand, K Santhosh, Harsha Basappa, C N Manjunath, Mohan H Nayak
Percutaneous transvenous mitral commissurotomy (PTMC) using Inoue/Accura balloon is an effective procedure for management of patients with rheumatic mitral stenosis.(1) Inability to cross the mitral valve is one of the pertinent reasons for procedural failure. We describe a series of three patients who were tackled with successful PTMC using a novel technique of veno-arterial looping and in the fourth patient we used double loop entry into left ventricle with veno-arterial rail and peripheral balloon dilatation for completing the PTMC...
March 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28451290/activation-and-characterization-of-a-cryptic-gene-cluster-reveals-a-cyclization-cascade-for-polycyclic-tetramate-macrolactams
#16
Subhasish Saha, Wenjun Zhang, Guangtao Zhang, Yiguang Zhu, Yuchan Chen, Wei Liu, Chengshan Yuan, Qingbo Zhang, Haibo Zhang, Liping Zhang, Weimin Zhang, Changsheng Zhang
Polycyclic tetramate macrolactams (PTMs) are a growing class of natural products and are derived from a hybrid polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS) pathway. PTM biosynthetic gene clusters are conserved and widely distributed in bacteria, however, most of them remain silent. Herein we report the activation of a PTM gene cluster in marine-derived Streptomyces pactum SCSIO 02999 by promoter engineering and heterologous expression, leading to the discovery of six new PTMs, pactamides A-F (11-16), with potent cytotoxic activity upon several human cancer cell lines...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28448763/analysis-of-postoperative-ultrasonography-surveillance-after-hemithyroidectomy-in-patients-with-papillary-thyroid-microcarcinoma-a-multicenter-study
#17
Hye Jin Baek, Dong Wook Kim, Chang Yoon Lee, Jung Yin Huh, Jin Yong Sung, Yoon Jung Choi
OBJECTIVE: The optimal follow-up interval for postoperative ultrasonography (US) surveillance after hemithyroidectomy in patients with papillary thyroid microcarcinoma (PTMC) is unclear. The purpose of this study was to evaluate the prevalence of tumor recurrence/persistence and to investigate the appropriateness of postoperative US surveillance in PTMC patients who underwent hemithyroidectomy. METHODS: Our institutional review board approved this retrospective study...
April 27, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28441803/-factors-for-lymph-node-metastasis-and-survival-rate-in-papillary-thyroid-microcarcinoma-from-a-large-cohort-of-3-607-cases-series
#18
L Xu, Y N Xu, J D Wang
Objective: To investigate high-risk factors for lymph node metastasis (LNM) and 10-year survival rate in patients with papillary thyroid microcarcinoma (PTMC). Methods: We retrospectively analyzed the clinical data of 3 607 patients with PTMC received surgery in our hospital from January 2005 to December 2015. Univariate and multivariate analyses were performed to identify the factors associated with metastasis and 10-year survival rate of the patients was calculated. Results: The patients accepted an average follow-up of 68 months, with follow-up from 18 to 138 months...
April 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28432268/clinical-outcomes-after-delayed-thyroid-surgery-in-patients-with-papillary-thyroid-microcarcinoma
#19
Min Ji Jeon, Won Gu Kim, Hyemi Kwon, Mijin Kim, Suyeon Park, Hye-Seon Oh, Minkyu Han, Tae-Yon Sung, Ki-Wook Chung, Suck Joon Hong, Tae Yong Kim, Young Kee Shong, Won Bae Kim
OBJECTIVE: Active surveillance is an option for patients with papillary thyroid microcarcinoma (PTMC). However, the long-term clinical outcomes after delayed surgery remain unclear. We compared the long-term clinical outcomes of PTMC patients according to the time interval between initial diagnosis and surgery. DESIGN AND METHODS: In this individual risk factor-matched cohort study, PTMC patients were classified into three groups according to the delay period: ≤6 months, 6-12 months and >12 months...
July 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28419171/ultrasound-texture-analysis-association-with-lymph-node-metastasis-of-papillary-thyroid-microcarcinoma
#20
Soo-Yeon Kim, Eunjung Lee, Se Jin Nam, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Kyung Hwa Han, Jin Young Kwak
This retrospective study aimed to evaluate whether ultrasound texture analysis is useful to predict lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC). This study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. Between May and July 2013, 361 patients (mean age, 43.8 ± 11.3 years; range, 16-72 years) who underwent staging ultrasound (US) and subsequent thyroidectomy for conventional PTMC ≤ 10 mm between May and July 2013 were included...
2017: PloS One
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