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https://www.readbyqxmd.com/read/28535653/-clinical-pathological-characteristics-of-resectable-papillary-thyroid-microcarcinoma
#1
C L Shi, Y Guo, Y C Lyu, Z A B Y S Nanding, W C Gao, T F Shi, H D Qin, S Y Liu
Objective: To investigate the difference of prognostic factors and recurrence rates between papillary thyroid microcarcinoma (PTMC) and lager papillary thyroid carcinoma (PTC) and analyze the clinical pathological characteristics of PTMC suitable for surgery. Methods: A retrospective analysis on the clinicopathological features, expression level of of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) V600E gene mutation and pigment epithelium-derived factor (PEDF), and postoperative follow-up results of the 251 PTC patients who underwent surgical treatment from October 2011 to October 2013, including 169 cases with PTMC and 82 with lager PTC (Tumor diameter>1 cm)...
May 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28534700/risk-factors-for-lymph-node-metastasis-lnm-in-patients-with-papillary-thyroid-microcarcinoma-ptmc-role-of-preoperative-ultrasound
#2
Cheng Zhao, Wenbin Jiang, Yuxiu Gao, Weidong Niu, Xiaojuan Zhang, Lei Xin
Objective This study aimed to investigate the risk factors and clinical value of lymph node metastasis (LNM) and missed central lymph node metastasis (CLNM) using preoperative ultrasound (US) in patients with papillary thyroid microcarcinoma (PTMC). Methods This retrospective study included 521 patients who underwent thyroidectomy for confirmed PTMC based on a final histological examination between January 2014 and June 2015. Based on the presence of LNM, 521 cases were divided into two groups: metastasis (218) and non-metastasis (303)...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28513128/clinical-features-of-recently-diagnosed-papillary-thyroid-carcinoma-in-elderly-patients-aged-65-and-older-based-on-10-years-of-sonographic-experience-at-a-single-institution-in-korea
#3
Eun Sil Kim, Younghen Lee, Hyungsuk Seo, Gil Soo Son, Soon Young Kwon, Young-Sik Kim, Ji-A Seo, Nan Hee Kim, Sang-Il Suh, Inseon Ryoo, Sung-Hye You
Purpose: The aim of this study was to assess the characteristics of papillary thyroid carcinoma (PTC) in patients aged 65 and older in order to predict postoperative recurrence based on the results of ultrasonographic surveillance. Methods: Among 1,494 patients (200 male and 1,294 female; mean age, 46.6±11.3 years) who underwent surgery for thyroid cancer at our institution between 2006 and 2015, we retrospectively enrolled 150 PTC patients (29 male and 121 female; mean age, 69...
April 13, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28506411/partial-thyroidectomy-for-papillary-thyroid-microcarcinoma-is-completion-total-thyroidectomy-indicated
#4
C Dobrinja, M Pastoricchio, M Troian, F Da Canal, S Bernardi, B Fabris, N de Manzini
AIM: Papillary thyroid microcarcinoma (PTMC) is increasing in incidence. Despite its excellent clinical outcomes, there is still debate regarding which surgical approach is more appropriate for PTMC, procedures including hemithyroidectomy (HT), total thyroidectomy (TT), and completion thyroidectomy (CT) after initial HT and histopathologic examination confirming a PTMC. Here we report our experience in the surgical management of PTMC. METHODS: We conducted a retrospective evaluation of all patients who received a postoperative diagnosis of PTMC between January 2001 and January 2016...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28500312/total-tumour-diameter-is-superior-to-unifocal-diameter-as-a-predictor-of-papillary-thyroid-microcarcinoma-prognosis
#5
Chunping Liu, Shuntao Wang, Wen Zeng, Yawen Guo, Zeming Liu, Tao Huang
The current American Joint Committee (AJCC) on Cancer TNM classification does not describe the treatment of multifocal papillary thyroid microcarcinomas (PTMCs) with a total tumour diameter (TTD) >1 cm. Herein, we investigated this PTMC subgroup in terms of extrathyroidal extension (ETE), local infiltration, central lymph node metastasis (LNM), and prognosis. Consecutive patients (n = 1102) were identified and the proportions of LNM, ETE, and local infiltration were similar between PTCs with a unifocal tumour diameter >1 cm and ≤2 cm and PTMCs with a multifocal TTD >1 cm and ≤2 cm...
May 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28476312/identification-of-risk-factors-of-central-lymph-node-metastasis-and-evaluation-of-the-effect-of-prophylactic-central-neck-dissection-on-migration-of-staging-and-risk-stratification-in-patients-with-clinically-node-negative-papillary-thyroid-microcarcinoma
#6
Jiru Yuan, Jinghua Li, Xiaoyi Chen, Xiaodong Lin, Jialin Du, Gang Zhao, Zhengbo Chen, Zeyu Wu
OBJECTIVE: The first aim of this study was to explore the risk factors that were associated with central lymph node metastasis (CLNM) in patients with clinically node-negative papillary thyroid microcarcinoma (cN0 PTMC) after prophylactic central neck dissection (PCND). The second aim was to evaluate the influence of PCND on migration of TNM staging and risk stratification (RS) in patients with cN0 PTMC. METHODS: A total of 295 cN0 PTMC patients who underwent thyroidectomy with PCND in the Department of General Surgery at Guangdong General Hospital between March 2014 to December 2015 were assessed retrospectively...
May 2, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28463605/comparison-of-poly-l-lactide-co-%C3%AE%C2%B5-caprolactone-and-poly-trimethylene-carbonate-membranes-for-urethral-regeneration-an-in-vitro-and-in-vivo-study
#7
Reetta Sartoneva, Panu Nordback, Suvi Haimi, Dirk W Grijpma, Kalle Lehto, Rooney Niall, Riitta Seppänen-Kaijansinkko Md Dds PhD, Susanna Miettinen, Tuija Lahdes-Vasama
Urethral defects are normally reconstructed using patient's own genital tissue; however, in severe cases, additional grafts are needed. We studied the suitability of poly(L-lactide-co-ε-caprolactone) (PLCL) and poly(trimethylene carbonate) (PTMC) membranes for urethral reconstruction in vivo. Further, the compatibility of the materials was evaluated in vitro with human urothelial cells (hUC). The attachment and viability of hUCs and the expression of different urothelial cell markers (Cytokeratin 7, 8, 19 and Uroplakin Ia, Ib and III) were studied after in vitro cell culture on PLCL and PTMC...
May 2, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28460768/case-series-difficult-ptmc-using-novel-technique-of-veno-arterial-looping
#8
Veena Nanjappa, K S Sadanand, K Santhosh, Harsha Basappa, C N Manjunath, Mohan H Nayak
Percutaneous transvenous mitral commissurotomy (PTMC) using Inoue/Accura balloon is an effective procedure for management of patients with rheumatic mitral stenosis.(1) Inability to cross the mitral valve is one of the pertinent reasons for procedural failure. We describe a series of three patients who were tackled with successful PTMC using a novel technique of veno-arterial looping and in the fourth patient we used double loop entry into left ventricle with veno-arterial rail and peripheral balloon dilatation for completing the PTMC...
March 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28451290/activation-and-characterization-of-a-cryptic-gene-cluster-reveals-a-cyclization-cascade-for-polycyclic-tetramate-macrolactams
#9
Subhasish Saha, Wenjun Zhang, Guangtao Zhang, Yiguang Zhu, Yuchan Chen, Wei Liu, Chengshan Yuan, Qingbo Zhang, Haibo Zhang, Liping Zhang, Weimin Zhang, Changsheng Zhang
Polycyclic tetramate macrolactams (PTMs) are a growing class of natural products and are derived from a hybrid polyketide synthase (PKS)/non-ribosomal peptide synthetase (NRPS) pathway. PTM biosynthetic gene clusters are conserved and widely distributed in bacteria, however, most of them remain silent. Herein we report the activation of a PTM gene cluster in marine-derived Streptomyces pactum SCSIO 02999 by promoter engineering and heterologous expression, leading to the discovery of six new PTMs, pactamides A-F (11-16), with potent cytotoxic activity upon several human cancer cell lines...
February 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28448763/analysis-of-postoperative-ultrasonography-surveillance-after-hemithyroidectomy-in-patients-with-papillary-thyroid-microcarcinoma-a-multicenter-study
#10
Hye Jin Baek, Dong Wook Kim, Chang Yoon Lee, Jung Yin Huh, Jin Yong Sung, Yoon Jung Choi
OBJECTIVE: The optimal follow-up interval for postoperative ultrasonography (US) surveillance after hemithyroidectomy in patients with papillary thyroid microcarcinoma (PTMC) is unclear. The purpose of this study was to evaluate the prevalence of tumor recurrence/persistence and to investigate the appropriateness of postoperative US surveillance in PTMC patients who underwent hemithyroidectomy. METHODS: Our institutional review board approved this retrospective study...
April 27, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28441803/-factors-for-lymph-node-metastasis-and-survival-rate-in-papillary-thyroid-microcarcinoma-from-a-large-cohort-of-3-607-cases-series
#11
L Xu, Y N Xu, J D Wang
Objective: To investigate high-risk factors for lymph node metastasis (LNM) and 10-year survival rate in patients with papillary thyroid microcarcinoma (PTMC). Methods: We retrospectively analyzed the clinical data of 3 607 patients with PTMC received surgery in our hospital from January 2005 to December 2015. Univariate and multivariate analyses were performed to identify the factors associated with metastasis and 10-year survival rate of the patients was calculated. Results: The patients accepted an average follow-up of 68 months, with follow-up from 18 to 138 months...
April 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28432268/clinical-outcomes-after-delayed-thyroid-surgery-in-patients-with-papillary-thyroid-microcarcinoma
#12
Min Ji Jeon, Won Gu Kim, Hyemi Kwon, Mijin Kim, Suyeon Park, Hye-Seon Oh, Minkyu Han, Tae-Yon Sung, Ki-Wook Chung, Suck Joon Hong, Tae Yong Kim, Young-Kee Shong, Won Bae Kim
OBJECTIVE: Active surveillance is an option for patients with papillary thyroid microcarcinoma (PTMC). However, the long-term clinical outcomes after delayed surgery remain unclear. We compared the long-term clinical outcomes of PTMC patients according to the time interval between initial diagnosis and surgery. DESIGN & METHODS: In this individual risk factor-matched cohort study, PTMC patients were classified into three groups according to the delay period: ≤ 6 months, 6-12 months, and > 12 months...
April 21, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28419171/ultrasound-texture-analysis-association-with-lymph-node-metastasis-of-papillary-thyroid-microcarcinoma
#13
Soo-Yeon Kim, Eunjung Lee, Se Jin Nam, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Kyung Hwa Han, Jin Young Kwak
This retrospective study aimed to evaluate whether ultrasound texture analysis is useful to predict lymph node metastasis in patients with papillary thyroid microcarcinoma (PTMC). This study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. Between May and July 2013, 361 patients (mean age, 43.8 ± 11.3 years; range, 16-72 years) who underwent staging ultrasound (US) and subsequent thyroidectomy for conventional PTMC ≤ 10 mm between May and July 2013 were included...
2017: PloS One
https://www.readbyqxmd.com/read/28402967/surface-curvature-in-triply-periodic-minimal-surface-architectures-as-a-distinct-design-parameter-in-preparing-advanced-tissue-engineering-scaffolds
#14
Sébastien B G Blanquer, Maike Werner, Markus Hannula, Shahriar Sharifi, Guillaume P R Lajoinie, David Eglin, Jari Hyttinen, André A Poot, Dirk W Grijpma
Reproduction of the anatomical structures and functions of tissues using cells and designed 3D scaffolds is an ongoing challenge. For this, scaffolds with appropriate biomorphic surfaces promoting cell attachment, proliferation and differentiation are needed. In this study, eight triply-periodic minimal surface (TPMS)-based scaffolds were designed using specific trigonometric equations, providing the same porosity and the same number of unit cells, while presenting different surface curvatures. The scaffolds were fabricated by stereolithography using a photocurable resin based on the biocompatible, biodegradable and rubber-like material, poly(trimethylene carbonate) (PTMC)...
April 12, 2017: Biofabrication
https://www.readbyqxmd.com/read/28382784/the-impact-of-presence-of-hashimoto-s-thyroiditis-on-diagnostic-accuracy-of-ultrasound-guided-fine-needle-aspiration-biopsy-in-subcentimeter-thyroid-nodules-a-retrospective-study-from-fuscc
#15
Lili Gao, Ben Ma, Li Zhou, Yu Wang, Shuwen Yang, Ning Qu, Yi Gao, Qinghai Ji
The incidence of PTMC has been increasing in the recent years. This study aimed to investigate the diagnostic value of US-FNA in thyroid nodules ≤1 cm and whether the presence of Hashimoto's thyroiditis (HT) in thyroid could influence the accuracy. The patients who accepted US-FNA at FUSCC from December 2012 to November 2015 and followed our criteria were enrolled in this study. We extracted the cytological, pathological, and follow-up US/US-FNA data of patients with subcentimeter nodules. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), false-negative rate (FNR), false-positive rate (FPR), and AUC were calculated to define FNA diagnostic performance in patients...
May 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28351086/independent-risk-factors-predicting-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma
#16
Xiaolong Yu, Xuejia Song, Wenhai Sun, Shihua Zhao, Jiajun Zhao, Yan-Gang Wang
The incidence of papillary thyroid microcarcinoma (PTMC) has risen rapidly in recent years, and PTMC patients with central lymph node metastasis (CLNM) usually have poor prognosis. Independent risk factors predicting CLNM in PTMC have not been well understood. The aim of our study was to identify useful clinicopathological risk factors predicting CLNM in PTMC patients. This was a retrospective study of 917 patients with PTMC treated with surgery from January 2014 to December 2015 in our hospital. The relationship between clinicopathological factors and CLNM was analyzed to identify those factors predicting CLNM in PTMC...
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28324106/clinical-features-of-early-and-late-postoperative-hypothyroidism-after-lobectomy
#17
Suyeon Park, Min Ji Jeon, Eyun Song, Hye-Seon Oh, Mijin Kim, Hyemi Kwon, Tae Yong Kim, Suck Joon Hong, Young Kee Shong, Won Bae Kim, Tae-Yon Sung, Won Gu Kim
Context: Lobectomy is preferred in thyroid cancer to decrease surgical complications and avoid lifelong thyroid-hormone replacement. However, postoperative hypothyroidism, requiring thyroid-hormone replacement, may occur. Objective: We aimed to identify the incidence and risk factors of postoperative hypothyroidism to develop a surveillance strategy after lobectomy for papillary thyroid microcarcinoma (PTMC). Methods: This historical cohort study involved 335 patients with PTMC treated by lobectomy...
April 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323932/active-surveillance-for-patients-with-papillary-thyroid-microcarcinoma-a-single-center-s-experience-in-korea
#18
Hyemi Kwon, Hye-Seon Oh, Mijin Kim, Suyeon Park, Min Ji Jeon, Won Gu Kim, Won Bae Kim, Young Kee Shong, Dong Eun Song, Jung Hwan Baek, Ki-Wook Chung, Tae Yong Kim
Context: Papillary thyroid microcarcinoma (PTMC) usually has an excellent prognosis. Objective: To evaluate the 3-dimensional structures of PTMCs using serial neck ultrasonography (US) in patients under active surveillance. Design and Setting: A retrospective cohort study. Participants: In total, 192 patients diagnosed with PTMC under active surveillance for more than 1 year were included in a median 30-month follow-up...
March 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28289666/is-familial-papillary-thyroid-microcarcinoma-more-aggressive-than-sporadic-form
#19
Cho Rok Lee, Seulkee Park, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung, Cheong Soo Park
PURPOSE: With the increasing incidence of papillary thyroid microcarcinoma (PTMC), familial papillary thyroid microcarcinoma (FPTMC) is now recognized more frequently. However, the biological behavior of FPTMC is poorly understood. The aim of this study was to investigate the prevalence of FPTMC and its biological aggressiveness. METHODS: Between March 2006 and July 2010, 2,414 patients underwent primary surgical therapy for PTMC and 149 (6.2%) were further classified as FPTMC...
March 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28286037/surface-enrichment-with-hydroxyapatite-nanoparticles-in-stereolithography-fabricated-composite-polymer-scaffolds-promotes-bone-repair
#20
O Guillaume, M A Geven, C M Sprecher, V A Stadelmann, D W Grijpma, T T Tang, L Qin, Y Lai, M Alini, J D de Bruijn, H Yuan, R G Richards, D Eglin
Fabrication of composite scaffolds using stereolithography (SLA) for bone tissue engineering has shown great promises. However, in order to trigger effective bone formation and implant integration, exogenous growth factors are commonly combined to scaffold materials. In this study, we fabricated biodegradable composite scaffolds using SLA and endowed them with osteopromotive properties in the absence of biologics. First we prepared photo-crosslinkable poly(trimethylene carbonate) (PTMC) resins containing 20 and 40wt% of hydroxyapatite (HA) nanoparticles and fabricated scaffolds with controlled macro-architecture...
March 7, 2017: Acta Biomaterialia
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