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https://www.readbyqxmd.com/read/27853812/ultrasound-guided-percutaneous-laser-ablation-of-unifocal-t1n0m0-papillary-thyroid-microcarcinoma-preliminary-results
#1
Wei Zhou, Shan Jiang, Weiwei Zhan, Jianqiao Zhou, Shangyan Xu, Lu Zhang
OBJECTIVES: To evaluate the efficacy and safety of percutaneous laser ablation (PLA) for unifocal T1N0M0 papillary thyroid microcarcinoma(PTMC). METHODS: A retrospective study was conducted in 30 patients with single PTMC which was diagnosed by fine-needle aspiration biopsy (FNAB). PLA was performed for proper time to achieve adequate ablation zones. The extent of ablation was assessed by contrast-enhanced ultrasound (CEUS) immediately and 7 days after PLA. Complications were recorded...
November 16, 2016: European Radiology
https://www.readbyqxmd.com/read/27835583/non-invasive-diagnosis-of-papillary-thyroid-microcarcinoma-a-nmr-based-metabolomics-approach
#2
Jinghui Lu, Sanyuan Hu, Paolo Miccoli, Qingdong Zeng, Shaozhuang Liu, Lin Ran, Chunxiao Hu
Papillary thyroid microcarcinoma (PTMC) is a subtype of papillary thyroid carcinoma (PTC). Because its diameter is less than 10 mm, diagnosing it accurately is difficult with traditional methods such as image examinations and FNA (Fine Needle Aspiration). Investigating the metabolic changes induced by PTMC may enhance the understanding of its pathogenesis and provide important information for a new diagnosis method and treatment plan. In this study, high resolution magic angle spin (HRMAS) spectroscopy and 1H-nuclear magnetic resonance (1H-NMR) spectroscopy were used to screen metabolic changes in thyroid tissues and plasma from PTMC patients respectively...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27806783/-clinicopathological-features-of-thyroid-papillary-microcarcinoma-of-which-the-maximum-diameter-is-less-than-5-mm-a-series-of-487-cases
#3
C Chen, H Z Chen, C H Lyu, S Xue, N K Yu, X Chen
Objective: To analyze the clinical and pathological features of papillary thyroid microcarcinoma(PTMC) of which the maximum diameter is less than 5 mm. Methods: Clinical data of 487 PTMC (≤5 mm) patients who underwent primary surgery by the same team of doctors between March 2013 to March 2016 at Department of Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University were analyzed retrospectively. Female patients accounted for 77.4%(377/487). The age ranged from 22 to 80 years, with an average of (46±11) years...
November 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27793009/the-changing-characteristics-and-molecular-profiles-of-papillary-thyroid-carcinoma-over-time-a-systematic-review
#4
REVIEW
Huy Gia Vuong, Ahmed M A Altibi, Amr Hesham Abdelhamid, Phuong Uyen Duong Ngoc, Vo Duy Quan, Mohamed Yousef Tantawi, Mohamed Elfil, Tran Le Huy Vu, Ahmed Elgebaly, Naoki Oishi, Tadao Nakazawa, Kenji Hirayama, Ryohei Katoh, Nguyen Tien Huy, Tetsuo Kondo
BACKGROUND: The genetic alterations of papillary thyroid carcinoma (PTC) have been reported to change over the past few decades. We performed this systematic review to further examine the trends and modifications of patient demographic, clinicopathological features and molecular profiles of PTC over time. METHODS: A literature search was performed within six electronic databases to identify relevant articles. The inclusion criteria were published studies investigating BRAF mutations, RET/PTC rearrangements or RAS mutations in PTCs or classical PTCs...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27782383/uv-crosslinkable-graphene-poly-trimethylene-carbonate-composites-for-3d-printing-of-electrically-conductive-scaffolds
#5
Sepidar Sayyar, Miina Bjorninen, Suvi Haimi, Susanna Miettinen, Kerry Gilmore, Dirk W Grijpma, Gordon G Wallace
Conductive, flexible graphene/poly(trimethylene carbonate)(PTMC) composites (PTMC-CCG) were prepared. Addition of just 3 wt.% graphene to PTMC oligomers functionalized with methacrylate end-groups followed by UV-crosslinking results in more than 100% improvement in tensile strength and enhanced electrical conductivity by orders of magnitude without altering the processability of the host material. The addition of graphene also enhances mesenchymal stem cell (MSC) attachment and proliferation. When electrical stimulation via the composite material is applied, MSC viability is not compromised and osteogenic markers are upregulated...
October 26, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27756889/a-meta-analysis-on-the-effect-of-operation-modes-on-the-recurrence-of-papillary-thyroid-microcarcinoma
#6
Dandan Yi, Peng Song, Tao Huang, Xiaoqiao Tang, Jianfeng Sang
Whether total thyroidectomy reduces the recurrence rate in patients with papillary thyroid microcarcinoma (PTMC) is currently controversy. Conclusions of sporadic, inconsistent, and mono-institutional studies need a meta-analysis to evaluate. 525 relevant studies were obtained from initial search on PubMed, 511 studies were excluded by inclusion and exclusion criteria. Eligible data were extracted from each included study. The Odds ratios (ORs) and 95% confidence interval (CI) were used to assess the difference in the recurrence rates between PTMC patients treated with total thyroidectomy and non-total thyroidectomy...
October 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27751337/ptmc-in-post-mv-repair-status
#7
Lachikarathman Devegowda, Prabhavathi Bhat, Cholenahally Nanjappa Manjunath, Prasanna Simha Mohan Rao
MV repair in the rheumatic population is feasible with acceptable long-term results.(1) Incidence of mitral stenosis (MS) following mitral valve (MV) repair for severe rheumatic mitral regurgitation (MR) and usefulness of percutaneous transluminal mitral valvuloplasty (PTMC) in these patients is not described in literature. We report a case of successful PTMC in severe MS following MV repair for severe rheumatic MR.
September 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27749574/is-papillary-thyroid-microcarcinoma-an-indolent-tumor-a-retrospective-study-on-280-cases-treated-with-radioiodine
#8
Xuemei Gao, Xiao Zhang, Yajing Zhang, Wenjuan Hua, Yusufu Maimaiti, Zairong Gao
The increasing detection of papillary thyroid microcarcinoma (PTMC) has created management dilemmas. To clarify the clinical significance of postsurgery stimulated thyroglobulin (ps-Tg) in PTMC who undergo thyroidectomy and radioactive iodine (RAI), we retrospectively reviewed the 358 PTMC patients who were treated with RAI and followed up in our hospital. Those with an excessive anti-Tg antibody, ultrasound-detected residual were excluded, thereby resulting in the inclusion of 280 cases. Their clinical and histopathological information and clinical outcomes were collected and summarized...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27698812/ultrasonic-features-of-papillary-thyroid-microcarcinoma-coexisting-with-a-thyroid-abnormality
#9
Bo Li, Yaqiong Zhang, Ping Yin, Jian Zhou, Tian'an Jiang
The present study aimed to investigate the value of ultrasonography in the diagnosis of papillary thyroid microcarcinoma (PTMC) coexisting with a thyroid abnormality, and to improve the accuracy of PTMC diagnosis. The ultrasonic features of 38 PTMC nodules coexisting with a thyroid abnormality and 56 thyroid benign nodules, obtained by surgical resection and confirmed by pathological analysis, were retrospectively analyzed. All masses were ≤ 1.0 cm in diameter. Ultrasonic features that were analyzed included the shape, aspect ratio, boundary, margin, echo, uniformity, presence or absence of microcalcification and enlargement of the lymph nodes, as well as the blood flow of the nodules...
October 2016: Oncology Letters
https://www.readbyqxmd.com/read/27645473/the-incidence-and-risk-factors-for-central-lymph-node-metastasis-in-cn0-papillary-thyroid-microcarcinoma-a-meta-analysis
#10
REVIEW
Liang-Sen Liu, Jia Liang, Jun-Hong Li, Xue Liu, Li Jiang, Jian-Xiong Long, Yue-Ming Jiang, Zhi-Xiao Wei
Although there have been many studies identifying clinical and pathologic factors that may predict central lymph node metastases (CLNM) in papillary thyroid microcarcinoma (PTMC) patients without clinically cervical lymph node metastasis (cN0), the results were inconsistent. And whether prophylactic central lymph node dissection (pCLND) should be performed in cN0 PTMC remains controversial. The EMBASE, PubMed, MEDLINE and the Cochrane Library were searched until Oct 2015 to identify relevant studies. Primary outcomes were clinical and pathologic factors for CLNM...
September 19, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27640247/opsonisation-of-nanoparticles-prepared-from-poly-%C3%AE-hydroxybutyrate-and-poly-trimethylene-carbonate-b-poly-malic-acid-amphiphilic-diblock-copolymers-impact-on-the-in-vitro-cell-uptake-by-primary-human-macrophages-and-heparg-hepatoma-cells
#11
Elise Vene, Ghislaine Barouti, Kathleen Jarnouen, Thomas Gicquel, Claudine Rauch, Catherine Ribault, Sophie M Guillaume, Sandrine Cammas-Marion, Pascal Loyer
The present work reports the investigation of the biocompatibility, opsonisation and cell uptake by human primary macrophages and HepaRG cells of nanoparticles (NPs) formulated from poly(β-malic acid)-b-poly(β-hydroxybutyrate) (PMLA-b-PHB) and poly(β-malic acid)-b-poly(trimethylene carbonate) (PMLA-b-PTMC) diblock copolymers, namely PMLA800-b-PHB7300, PMLA4500-b-PHB4400, PMLA2500-b-PTMC2800 and PMLA4300-b-PTMC1400. NPs derived from PMLA-b-PHB and PMLA-b-PTMC do not trigger lactate dehydrogenase release and do not activate the secretion of pro-inflammatory cytokines demonstrating the excellent biocompatibility of these copolymers derived nano-objects...
September 15, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27601922/risk-prediction-and-clinical-model-building-for-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma
#12
Dao-Zhe Lin, Ning Qu, Rong-Liang Shi, Zhong-Wu Lu, Qing-Hai Ji, Wei-Li Wu
The surgical management of papillary thyroid microcarcinoma (PTMC), especially regarding the necessity of central/lateral lymph node dissection, remains controversial. This study investigated the clinicopathologic factors predictive of lymph node metastasis (LNM) in patients diagnosed with PTMC. Multivariate logistic regression analysis was used for PTMC patients identified from the Surveillance, Epidemiology, and End Results database who were treated by surgery between 2002 and 2012, to determine the association of clinicopathologic factors with LNM...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27599271/a-mutasynthetic-library-of-platensimycin-and-platencin-analogues
#13
Liao-Bin Dong, Jeffrey D Rudolf, Ben Shen
Inactivation of ptmB1, ptmB2, ptmT2, or ptmC in Streptomyces platensis SB12029, a platensimycin (PTM) and platencin (PTN) overproducer, revealed that PTM and PTN biosynthesis features two distinct moieties that are individually constructed and convergently coupled to afford PTM and PTN. A focused library of PTM and PTN analogues was generated by mutasynthesis in the ΔptmB1 mutant S. platensis SB12032. Of the 34 aryl variants tested, 18 were incorporated with high titers.
September 16, 2016: Organic Letters
https://www.readbyqxmd.com/read/27541032/how-many-contralateral-carcinomas-in-patients-with-unilateral-papillary-thyroid-microcarcinoma-are-preoperatively-misdiagnosed-as-benign
#14
Zeng Gui Wu, Xing Qiang Yan, Ru Si Su, Zhao Sheng Ma, Bo Jian Xie, Fei Lin Cao
BACKGROUND: The decision to perform a total thyroidectomy (TT) for unilateral papillary thyroid microcarcinoma (PTMC) with nodules in the contralateral lobe remains controversial. The aim of this study was to investigate the rate of contralateral carcinomas that are preoperatively misdiagnosed as benign. METHODS: From October 2011 to October 2015, a total of 347 patients with unilateral PTMC and contralateral benign nodules who were treated with a TT at a single institution were enrolled...
August 19, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27523997/design-and-synthesis-of-an-amphiphilic-graft-hydrogel-having-a-hydrophobic-domain-formed-by-multiple-interactions
#15
Kyohei Nitta, Atsushi Kimoto, Junji Watanabe
A novel hydrogel having hydrophobic oligo segments and hydrophilic poly(acrylamidoglycolic acid) (PAGA) as pH responsive polymer segments was designed and synthesized to be used as a soft biomaterial. Poly(trimethylene carbonate) (PTMC) as the side chain, for which the degrees of polymerization were 9, 19, and 49, and the composition ratios were 1, 5, and 10mol%, was used as the oligo segment in the hydrogel. The swelling ratio of the hydrogel was investigated under various changes in conditions such as pH, temperature, and hydrogen bonding upon urea addition...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27475736/risk-factors-for-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-older-patients-with-fewer-lymph-node-metastases
#16
L Zhang, J Yang, Q Sun, Y Liu, F Liang, Z Liu, G Chen, S Chen, Z Shang, Y Li, X Li
BACKGROUND: Lymph node metastasis (LNM) is an important consideration in treatment strategy selection for papillary thyroid microcarcinoma (PTMC). The aim of this study was to investigate the risk factors for LNM and high-volume LNM (hvLNM, >5 metastatic lymph nodes). METHODS: A consecutive series of 1226 PTMC (947 female, 279 male) patients was reviewed. All patients underwent at least central neck dissection. Clinical-pathological features were assessed. All patients were allocated into Group A (≤39 yrs), Group B (40-59 yrs), or Group C (≥60 yrs) for risk factor analysis...
October 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27461608/comparison-between-endoscopic-thyroidectomy-and-conventional-open-thyroidectomy-for-papillary-thyroid-microcarcinoma-a-meta-analysis
#17
Yujie Li, Xiaodong Zhou
BACKGROUND: Endoscopic thyroidectomy (ET) has gained acceptance among surgeons as its feasibility has been well-documented. The aim of this systematic review with meta-analysis has been to assess and validate the safety and feasibility of ET when compared to conventional open thyroidectomy (COT) for papillary thyroid microcarcinoma (PTMC) and to verify other potential benefits and drawbacks. MATERIALS AND METHODS: PubMed, Web of Knowledge are searched for studies concerning treatment for papillary thyroid microcarcinoma between 2000 and 2013, the method of meta-analysis is performed to compare the effect of different treatment...
April 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27445090/efficacy-and-safety-of-ultrasound-guided-radiofrequency-ablation-for-treating-low-risk-papillary-thyroid-microcarcinoma-a-prospective-study
#18
Mingbo Zhang, Yukun Luo, Yan Zhang, Jie Tang
BACKGROUND: Papillary thyroid microcarcinoma (PTMC) has a high incidence and a good prognosis. Surgical operation for all PTMC might be an overtreatment. The objective of this study was to evaluate the efficacy and safety of ultrasound (US)-guided radiofrequency ablation (RFA) for treating low-risk PTMC. METHODS: Ninety-eight PTMC in 92 patients were included in this study. US and contrast-enhanced ultrasound (CEUS) examinations were performed before ablation. RFA was performed using the moving-shot technique...
November 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27416738/predicting-extrathyroidal-extension-in-patients-with-papillary-thyroid-microcarcinoma-according-to-a-braf-mutation
#19
Doh Young Lee, Soo Min Hwang, Jee Hyun An, Kyu Ri Son, Seung-Kuk Baek, Sin Gon Kim, Yang Seok Chae, Kwang-Yoon Jung
Objectives: The aim of this study was to evaluate the association between preoperative parameters and extrathyroidal extension (ETE) of papillary thyroid microcarcinoma (PTMC) according to the BRAF mutation and to evaluate the preoperative predictability of ETE. Methods: We analyzed the medical records of 332 patients with PTMC (140 in the BRAF- group and 192 in the BRAF+ group). The presence of ETE was subjected to a correlation analysis with age, sex, tumor size, clinical nodal status, and ultrasonography (US) findings...
July 2, 2016: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/27397594/pathological-characteristics-of-low-risk-papillary-thyroid-microcarcinoma-with-progression-during-active-surveillance
#20
Mitsuyoshi Hirokawa, Takumi Kudo, Hisashi Ota, Ayana Suzuki, Akira Miyauchi
Papillary thyroid microcarcinoma (PTMC) is generally an indolent disease and active surveillance is conducted for low-risk cases. This study was carried out to clarify the pathological characteristics of PTMC cases that exhibited enlarged nodules or nodal metastasis during the surveillance period. A total of 188 PTMC cases that underwent surgery after active surveillance for ≥ 1 year were examined. Ki-67 labeling indices of > 5% and > 10% were detected in 50.0% and 22.2% of enlarged cases, respectively, values that were significantly higher than those in non-enlarged cases...
September 30, 2016: Endocrine Journal
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