keyword
https://read.qxmd.com/read/38497388/radiofrequency-ablation-for-papillary-thyroid-microcarcinoma-close-to-the-thyroid-capsule-versus-far-from-the-thyroid-capsule-a-retrospective-study
#1
JOURNAL ARTICLE
Jieli Luo, Tianchen Hui, Peile Jin, Yang Sun, Yajun Chen, Zimei Lin, Pintong Huang
INTRODUCTION: The aim of this study was to evaluate the safety and efficacy of ultrasound-guided radiofrequency ablation (RFA) for the management of papillary thyroid microcarcinoma (PTMC) close to the thyroid capsule. MATERIAL AND METHODS: This was a retrospective study of 202 patients with PTMC who underwent RFA close to the thyroid capsule and 80 patients with PTMC who underwent RFA far from the thyroid capsule between June 2015 and December 2022. The follow-up time after RFA, change in size of tumour, location, thyroid function, the rates of PTMC disappearance, and complications were evaluated...
2024: Endokrynologia Polska
https://read.qxmd.com/read/38487589/papillary-muscle-rupture-without-severe-mitral-regurgitation-following-percutaneous-balloon-mitral-commissurotomy-a-case-report
#2
Pierre Rossignon, Sofia Morra, Quentin de Hemptinne, Didier de Cannière, Philippe Unger
BACKGROUND: Percutaneous transvenous mitral commissurotomy (PTMC) is the first-line therapy of clinically significant rheumatic mitral stenosis. While the procedure is generally safe, new onset or aggravation of mitral regurgitation (MR) may occur, mainly due to commissural splitting and, less frequently, to leaflet tear and chordal rupture. Papillary muscle rupture (PMR) is exceedingly rare in this setting. CASE SUMMARY: A 74-year-old woman with a history of aortic valve replacement and prior rheumatic mitral commissurotomy presented for worsening exercise intolerance and exertional dyspnoea...
March 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38481630/retrospective-analysis-of-the-efficacy-and-safety-of-ultrasound-guided-radiofrequency-ablation-in-the-treatment-of-papillary-thyroid-microcarcinoma-a-follow-up-study-of-continuous-postoperative-surveillance-and-large-sample-data
#3
JOURNAL ARTICLE
Gongli Zhou, Xuefeng Zhang, Ke Xu, Beibei Zhang, Ruiqing Su, Tingting Cai, Wei Zhao, Feng Li
OBJECTIVE: To retrospectively evaluate the efficacy and safety of ultrasound-guided radiofrequency ablation (RFA) in the treatment of papillary thyroid microcarcinoma (PTMC) through a follow-up study of continuous postoperative surveillance and large-sample data. METHODS: The efficacy of ultrasound-guided RFA was evaluated by measuring the tumor volume reduction rate (VRR), tumor disappearance rate, and disease progression in 358 patients with low-risk unifocal PTMC who underwent ultrasound-guided RFA at Hangzhou Weja Hospital, while the safety was evaluated by measuring their complications...
2024: International Journal of Endocrinology
https://read.qxmd.com/read/38462410/the-overtreatment-of-papillary-thyroid-microcarcinoma-in-the-community
#4
JOURNAL ARTICLE
Peter J Abraham, Christopher Wu, Rongzhi Wang, Brendon Herring, Polina Zmijewski, Andrea Gillis, Jessica Fazendin, Brenessa Lindeman, Herbert Chen
INTRODUCTION: Total thyroidectomy is the traditional primary approach for papillary thyroid cancer. However, recent evidence supports conservative management for low-risk tumors like papillary thyroid microcarcinomas (PTMCs). This study explores the adoption of these practices in our community, using a cancer database to analyze treatment strategies. METHODS: A retrospective review of a 1433-patient institutional database identified 258 ​PTMC cases. Outcomes, including 30-day mortality, reoperation rate, postoperative hypocalcemia, and recurrent laryngeal nerve (RLN) injury, were assessed...
March 4, 2024: American Journal of Surgery
https://read.qxmd.com/read/38446376/papillary-thyroid-carcinoma-%C3%A2-%C3%A2-%C3%A2-10%C3%A2-mm-does-not-always-mean-pn0-a-multicentric-real-world-study
#5
JOURNAL ARTICLE
Stefano Amendola, Tommaso Piticchio, Lorenzo Scappaticcio, Sium Wolde Sellasie, Salvatore Volpe, Rosario Le Moli, Luigi Coppola, Leo Guidobaldi, Francesco Pedicini, Carla Carbone, Paola Caruso, Elena Gamarra, Giovanni Docimo, Francesco Frasca, Luigi Uccioli, Pierpaolo Trimboli
The incidence of papillary thyroid carcinoma (PTC) is increasing and PTC ≤ 10 mm (PTMC) accounts for most new diagnoses. PTMCs are not always low risk, as detection of lymph nodes metastasis (LNM) may occur. The purpose of the study was to analyze the clinical pattern, frequency, and independent risk factors of patients with PTMC and LNM. From January 2022 to June 2023, PTCs managed at CTO Hospital, Rome; Policlinico Vanvitelli, Naples; and Garibaldi Nesima Hospital, Catania were included...
March 6, 2024: Updates in Surgery
https://read.qxmd.com/read/38441255/accurate-preoperative-prediction-of-nodal-metastasis-in-papillary-thyroid-microcarcinoma-towards-optimal-management-of-patients
#6
JOURNAL ARTICLE
Si-Ying Lin, Meng-Yao Li, Chi-Peng Zhou, Wei Ao, Wen-Yu Huang, Si-Si Wang, Jia-Fan Yu, Zi-Han Tang, Amr H Abdelhamid Ahmed, Ting-Yi Wang, Zhi-Hong Wang, Surong Hua, Gregory W Randolph, Wen-Xin Zhao, Bo Wang
OBJECTIVE: To enhance the accuracy in predicting lymph node metastasis (LNM) preoperatively in patients with papillary thyroid microcarcinoma (PTMC), refining the "low-risk" classification for tailored treatment strategies. METHODS: This study involves the development and validation of a predictive model using a cohort of 1004 patients with PTMC undergoing thyroidectomy along with central neck dissection. The data was divided into a training cohort (n = 702) and a validation cohort (n = 302)...
March 5, 2024: Head & Neck
https://read.qxmd.com/read/38438216/papillary-thyroid-microcarcinoma-with-and-without-nodal-metastasis-a-comparative-analysis
#7
JOURNAL ARTICLE
Saleh Alqaryan, Hisham Almousa, Raed Almutairi, Ahmed Altuwaijri, Aseel Doubi, Zuhour Alqahtani, Mohammad Almayouf, Majed Albarrak, Mohammed Alessa, Saleh Aldhahri, Khalid Alqahtani
OBJECTIVES: To assess the demographics and clinical factors of papillary thyroid microcarcinoma (PTMC) patients in Saudi Arabia and compared and analyzed the differences between the patients with and without lymph node metastasis (LNM). Papillary thyroid microcarcinoma (PTMC) is a common thyroid cancer and is not usually detectable clinically but found incidentally after pathologic evaluation of thyroid tissue following surgery for benign thyroid disorders. However, these tumors have a significant risk of LNM...
March 2024: Saudi Medical Journal
https://read.qxmd.com/read/38410213/the-ultrasound-based-radiomics-clinical-machine-learning-model-to-predict-papillary-thyroid-microcarcinoma-in-ti-rads-3-nodules
#8
JOURNAL ARTICLE
Zhang Chen, Wenting Zhan, Zhijing Wu, Huiliao He, Shaoyi Wang, Xiaoyan Huang, Zhihua Xu, Yan Yang
BACKGROUND: Conventional ultrasound (CUS) technology has proven to be successful in the identification of thyroid nodules. Moreover, the American College of Radiology Thyroid Imaging Reporting and Data System (ACR TI-RADS) was developed for the purpose of evaluating the risk of thyroid nodules based on ultrasound imaging. Nevertheless, identifying papillary thyroid microcarcinoma (PTMC) from TI-RADS 3 nodules using this system can be difficult due to overlapping morphological features...
January 31, 2024: Translational Cancer Research
https://read.qxmd.com/read/38401080/application-of-non-ligation-technique-in-thyroidectomy
#9
JOURNAL ARTICLE
Chengyu Pang, Jianming Yuan, Ru Zhou, Qiaofeng Chen, Tianxiang Wang, Weize Wu, Xunbo Huang
OBJECTIVE: This study aimed to analyze the difference between non-ligation and traditional ligation techniques for papillary thyroid micro-carcinoma (PTMC) patients. METHODS: Patients undergoing thyroidectomy in the Department of General Surgery, Ruijin Hospital, affiliated with Shanghai Jiao Tong University, Lu Wan Branch, were retrospectively enrolled. The gender, age, operation method, operation duration, tumor size, size of thyroidectomy specimen, postoperative bleeding, drainage volume on the first postoperative day, preoperative and postoperative levels of parathyroid hormone (PTH), and blood calcium were collected...
February 9, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38392064/papillary-thyroid-microcarcinoma-differences-between-lesions-in-incidental-and-nonincidental-settings-considerations-on-these-clinical-entities-and-personal-experience
#10
JOURNAL ARTICLE
Giorgio Lucandri, Giulia Fiori, Francesco Falbo, Vito Pende, Massimo Farina, Paolo Mazzocchi, Assunta Santonati, Daniela Bosco, Antonio Spada, Emanuele Santoro
Papillary thyroid microcarcinoma (PTMC) represents 35-40% of all papillary cancers; it is defined as a nodule ≤ 10 mm at the time of histological diagnosis. The clinical significance of PTMC is still controversial, and it may be discovered in two settings: incidental PTMC (iPTMC), in which it is identified postoperatively upon histological examination of thyroid specimens following thyroid surgery for benign disease, and nonincidental PTMC (niPTMC), in which it is diagnosed before surgery. While iPTMC appears to be related to mild behavior and favorable clinical outcomes, niPTMC may exhibit markers of aggressiveness...
February 6, 2024: Current Oncology
https://read.qxmd.com/read/38389061/a-nomogram-for-predicting-adverse-pathologic-features-in-low-risk-papillary-thyroid-microcarcinoma
#11
JOURNAL ARTICLE
Lei Gong, Ping Li, Jingjing Liu, Yan Liu, Xinghong Guo, Weili Liang, Bin Lv, Peng Su, Kai Liang
BACKGROUND: Identifying risk factors for adverse pathologic features in low-risk papillary thyroid microcarcinoma (PTMC) can provide valuable insights into the necessity of surgical or non-surgical treatment. This study aims to develop a nomogram for predicting the probability of adverse pathologic features in low-risk PTMC patients. METHODS: A total of 662 patients with low-risk PTMC who underwent thyroid surgery were retrospectively analyzed in Qilu Hospital of Shandong University from May 2019 to December 2021...
February 22, 2024: BMC Cancer
https://read.qxmd.com/read/38378515/development-of-a-nomogram-for-prediction-of-central-lymph-node-metastasis-of-papillary-thyroid-microcarcinoma
#12
JOURNAL ARTICLE
Pengjun Qiu, Qiaonan Guo, Kelun Pan, Jianqing Lin
BACKGROUND: Papillary thyroid carcinoma (PTC) is the most frequent malignant tumor in thyroid carcinoma. The aim of this study was to explore the risk factors associated with central lymph node metastasis in papillary thyroid microcarcinoma (PTMC) and establish a nomogram model that can assess the probability of central lymph node metastasis (CLNM). METHODS: The clinicopathological data of 377 patients with cN0 PTMC were collected and analyzed from The Second Affiliated Hospital of Fujian Medical University from July 1st , 2019 to December 30th , 2021...
February 20, 2024: BMC Cancer
https://read.qxmd.com/read/38369523/ultrasound-radiomics-signature-for-predicting-central-lymph-node-metastasis-in-clinically-node-negative-papillary-thyroid-microcarcinoma
#13
JOURNAL ARTICLE
Jie Liu, Jingchao Yu, Yanan Wei, Wei Li, Jinle Lu, Yating Chen, Meng Wang
BACKGROUND: Whether prophylactic central lymph node dissection is necessary for patients with clinically node-negative (cN0) papillary thyroid microcarcinoma (PTMC) remains controversial. Herein, we aimed to establish an ultrasound (US) radiomics (Rad) score for assessing the probability of central lymph node metastasis (CLNM) in such patients. METHODS: 480 patients (327 in the training cohort, 153 in the validation cohort) who underwent thyroid surgery for cN0 PTMC at two institutions between January 2018 and December 2020 were included...
February 19, 2024: Thyroid Research
https://read.qxmd.com/read/38337071/the-relationship-between-ablation-range-and-ablation-energy-in-papillary-thyroid-microcarcinoma-a-comparison-between-microwave-ablation-and-laser-ablation
#14
JOURNAL ARTICLE
Xinyu Zhong, Yuting Cao, Xinghao Zhang, Wengang Liu, Ping Zhou
OBJECTIVES: To study the relationship between the ablation range and applied energy of laser ablation (LA) and microwave ablation (MWA) in papillary thyroid microcarcinoma (PTMC). METHODS: A total of 201 PTMC patients were treated with LA (n = 102) or MWA (n = 99) with single-applicator fixed ablation. The ablation range was determined by contrast-enhanced ultrasound. The ratios of ablation volume, longitudinal diameter, and orthogonal diameter to ablation energy (RAV/E , RAL/E , RAO/E ) were analyzed and compared between MWA and LA...
February 10, 2024: European Radiology
https://read.qxmd.com/read/38327414/efficacy-and-safety-of-thermal-ablation-modalities-for-the-treatment-of-papillary-thyroid-microcarcinoma-systematic-review-and-network-meta-analysis
#15
JOURNAL ARTICLE
Binyi Li, Ying Qian, Yong Huang, Zheng Li
BACKGROUND: Thermal ablation (TA) modalities such as radiofrequency ablation (RFA), microwave ablation (MWA), and laser ablation (LA) have been widely used in the treatment of papillary thyroid microcarcinoma (PTMC) patients. Based on previous small-sample meta-analyses, this network meta was designed to further compare the efficacy and safety of these thermal ablation methods in PTMC patients. METHODS: China National Knowledge Infrastructure (CNKI), Wanfang, PubMed, Embase, and the Cochrane Library databases were searched to retrieve relevant studies published before May 2022...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38326996/feasibility-of-whole-exome-sequencing-in-fine-needle-aspiration-specimens-of-papillary-thyroid-microcarcinoma-for-the-identification-of-novel-gene-mutations
#16
JOURNAL ARTICLE
Liyuan Ma, Luying Gao, Ya Hu, Xiaoyi Li, Chunhao Liu, Jiang Ji, Xinlong Shi, Aonan Pan, Yuang An, Nengwen Luo, Yu Xia, Yuxin Jiang
Genetic profiling is important for assisting the management of papillary thyroid microcarcinoma (PTMC). Although whole-exome sequencing (WES) of surgically resected PTMC tissue has been performed and revealed potential prognostic biomarkers, its application in PTMC fine-needle aspiration (FNA) specimens has not been explored. This study aimed to evaluate the feasibility of WES using FNA specimens of PTMC. Five PTMC patients were enrolled with clinical characteristics gathered. Fine aspiration cytology needle (23 gauges) was used to collect FNA biopsy with ultrasound guidance...
February 7, 2024: Clinical Genetics
https://read.qxmd.com/read/38319587/thermal-ablation-for-multifocal-papillary-thyroid-microcarcinoma-a-systematic-review-and-meta-analysis
#17
REVIEW
Junping Zhang, Jiarong Liu, Wanting Yi, Yanling Liu, Ying Liu, Jixiong Xu
BACKGROUND: Clinical studies have indicated the potential safety and efficacy of thermal ablation (TA) in treating multifocal papillary thyroid microcarcinoma (MPTMC). However, a comprehensive systematic evaluation of its effectiveness was still lack. METHODS: PubMed, EMBASE and Cochrane Library databases were systematically searched for studies published until October 23, 2023, that reported on the effectiveness of thermal ablation in the management of MPTMC. Data extraction and methodological quality assessment were independently conducted by two reviewers following the guidelines outlined in the PRISMA...
February 6, 2024: Endocrine
https://read.qxmd.com/read/38318059/a-modified-single-incision-gasless-endoscopic-thyroidectomy-and-bilateral-central-neck-dissection-via-axillary-approach-technique-for-bilateral-papillary-thyroid-microcarcinoma-a-preliminary-report
#18
JOURNAL ARTICLE
Shi-Tong Yu, Jun-Na Ge, Bai-Hui Sun, Zhi-Gang Wei, Zhi-Cheng Zhang, Wei-Sheng Chen, Ting-Ting Li, Shang-Tong Lei
BACKGROUND: Our objective was to assess the viability and oncological security of a gasless, transaxillary single-incision endoscopic procedure for performing total thyroidectomy and bilateral central neck dissection (TT + BCND). This study focused on patients diagnosed with bilateral papillary thyroid microcarcinoma (PTMC). METHOD: Between April 2020 and November 2021, 22 patients with bilateral PTMC underwent single-incision, gasless, transaxillary endoscopic TT + BCND...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38294035/-in-silico-approaches-to-investigate-enzyme-immobilization-a-comprehensive-systematic-review
#19
REVIEW
Farzaneh Barati, Fakhrisadat Hosseini, Rayeheh Vafaee, Zahra Sabouri, Parinaz Ghadam, Seyed Shahriar Arab, Najmeh Shadfar, Firoozeh Piroozmand
Enzymes are popular catalysts with many applications, especially in industry. Biocatalyst usage on a large scale is facing some limitations, such as low operational stability, low recyclability, and high enzyme cost. Enzyme immobilization is a beneficial strategy to solve these problems. Bioinformatics tools can often correctly predict immobilization outcomes, resulting in a cost-effective experimental phase with the least time consumed. This study provides an overview of in silico methods predicting immobilization processes via a comprehensive systematic review of published articles till 11 December 2022...
January 31, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38268989/whether-detection-of-gene-mutations-could-identify-low-or-high-risk-papillary-thyroid-microcarcinoma-data-from-393-cases-using-the-next-generation-sequencing
#20
JOURNAL ARTICLE
Lei Jin, Liang Zhou, Jian-Biao Wang, Li Tao, Xiao-Xiao Lu, Na Yan, Qian-Ming Chen, Li-Ping Cao, Lei Xie
OBJECTIVE: The objective of this study is to explore the utilization of next-generation sequencing (NGS) technology in evaluating the likelihood of identifying individuals with papillary thyroid microcarcinoma (PTMC ≤10 mm) who are at high or low risk. DESIGN: NGS was used to analyze 393 formalin-fixed, paraffin-embedded tissues of PTC tumors, all of which were smaller than 15 mm. RESULTS: The study found that bilateralism, multifocality, intrathyroidal spread, and extrathyroidal extension were present in 84 (21...
2024: International Journal of Endocrinology
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