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KangNan Mo, Ming Zhao, KeJing Wang, JiaLei Gu, Zhuo Tan
Endoscopic thyroidectomy (ET) via an axillo-breast (ABA), axillary or breast approach (BA) is effective for treatment of unilateral papillary thyroid microcarcinoma (PTMC). However, several disadvantages still exist, including inconvenience for using endoscopic instruments and poor cosmetic results. Here, we introduced a modified ABA (MABA) to overcome these disadvantages and evaluated its therapeutic outcomes by comparison with conventional BA.Fifty-five patients undergoing ET via MABA (n = 22) or BA (n = 33) for PTMC were retrospectively enrolled between June 2012 and June 2015...
November 2018: Medicine (Baltimore)
Wenjing Zhao, Shaobo Chen, Xianming Hou, Quan Liao, Ge Chen, Yupei Zhao
This study was designed to determine the incidence and predictive factors for lateral lymph node metastasis (LNM) in patients with papillary thyroid microcarcinoma (PTMC). From January 2014 to July 2015, a retrospective review was conducted of 215 patients with PTMC who underwent total thyroidectomy and central lymph node dissection (LND) with lateral LND. Correlations of lateral LNM with clinicopathological features were examined using univariate analyses. Risk factors for lateral LNM were identified by multivariate analysis...
October 26, 2018: Pathology Oncology Research: POR
Guohua Shen, Ying Kou, Bin Liu, Rui Huang, Anren Kuang
OBJECTIVES: Preclinical studies showed that BRAF mutation significantly reduced radioiodine uptake and decreased the sensitivity to radioactive iodine (RAI) therapy. However, clinical data regarding its role in therapeutic decision making with respect to RAI therapy are currently insufficient. Thus, this study aimed to evaluate the effect of BRAF mutation on the clinical response to RAI therapy for papillary thyroid microcarcinoma (PTMC) with intermediate-risk to high-risk features. PATIENTS AND METHODS: From January 2012 and October 2015, consecutive patients with PTMC with intermediate-risk to high-risk features who underwent RAI therapy were retrospectively included...
October 11, 2018: Nuclear Medicine Communications
Krzysztof Kaliszewski, Agnieszka Zubkiewicz-Kucharska, Paweł Kiełb, Jerzy Maksymowicz, Aleksander Krawczyk, Otto Krawiec
BACKGROUND: The incidence of papillary thyroid microcarcinoma (PTMC) is increasing; however, it is not clear whether this reflects an increase in the incidence of incidental or in that of non-incidentally (presurgically) discovered PTMC (IPTMC vs. NIPTMC). We assessed the incidence of IPTMC and NIPTMC over the past 9 years, to discern whether the increase in PTMC incidence is due to improved diagnostics or to a real increase in the incidence. METHODS: We performed a retrospective chart review of 4327 patients who were consecutively admitted to and surgically treated for thyroid pathology at a single institution...
October 10, 2018: World Journal of Surgical Oncology
Ho Jin Son, Jeong Kyu Kim, Young Do Jung, Gyu Ho Jang, Youn Tae Seo, Deok Su Kim, Sung Hwan Park, Young Ju Jeong
BACKGROUND: There have been arguments over the efficacy of elective unilateral central neck dissection (CND) in patients with papillary thyroid carcinoma (PTC) <1 cm who underwent hemithyroidectomy. This study was designed to investigate locoregional recurrence and postoperative complications related to elective unilateral CND for papillary thyroid microcarcinoma (PTMC). METHODS: Five hundred thirty-seven patients who underwent hemithyroidectomy, with or without CND for PTMC, were included...
October 10, 2018: Head & Neck
Xin Wu, Binglu Li, Chaoji Zheng, Xiaodong He
OBJECTIVES: Papillary thyroid carcinoma with a maximum tumor diameter no more than 10 mm is defined as papillary thyroid microcarcinoma (PTMC). The proportion of newly diagnosed PTMC has increased significantly in recent years. Different guidelines have different comments about optimal management of PTMC, especially on prophylactic central lymph node (CLN) dissection. The aim of the present study is to analyze the risk factors for CLN metastases in patients with PTMC. METHODS: A total of 4389 patients underwent thyroid surgery at our center from January 2017 to March 2018, and 2129 patients with PTMC were selected and assessed retrospectively...
October 5, 2018: Endocrine Practice
Xi Zhang, Mike A Geven, Xinluan Wang, Ling Qin, Dirk W Grijpma, Ton Peijs, David Eglin, Olivier Guillaume, Julien E Gautrot
Background: Poly(trimethylene carbonate) (PTMC) has wide biomedical applications in the field of tissue engineering, due to its biocompatibility and biodegradability features. Its common manufacturing involves photofabrication, such as stereolithography (SLA), which allows the fabrication of complex and controlled structures. Despite the great potential of SLA-fabricated scaffolds, very few examples of PTMC-based drug delivery systems fabricated using photo-fabrication can be found ascribed to light-triggered therapeutics instability, degradation, side reaction, binding to the macromers, etc...
2018: International Journal of Nanomedicine
Jianlu Song, Shouxin Wu, Xiaotian Xia, Yu Wang, Youben Fan, Zhili Yang
BACKGROUND: Approximately half of the documented increases in differentiated thyroid carcinoma is due to identification of papillary thyroid microcarcinomas (PTMCs). Knowing whether PTMC is aggressive is required for proper treatment, but until now, there has been no method for assessing these traits and understanding the underlying mechanisms for aggressiveness. METHODS: We performed whole-exome sequencing of 16 PTMCs and matched normal thyroid tissues and GO/KEGG analysis to study genetic alterations and biological consequences associated with aggressive PTMCs, and then sequenced these genes using a next-generation gene-panel approach in an additional 70 PTMC samples including aggressive (n = 50) and non-aggressive (n = 20) groups...
October 1, 2018: Journal of Translational Medicine
Deepak Thakur, Yerramareddy Vijaya Chandra, Chinnasamy Sivaprakasam Muthukumaran
Rheumatic heart disease (RHD) is a major health hazard in most developing countries as well as sporadically in developed economies with high prevalence rates. Mitral stenosis is among the important morbid valvular conditions accounting for 25% of RHD cases. Percutaneous transmitral commissurotomy (PTMC) using Inoue balloon is the standard treatment for severe mitral stenosis with favorable Wilkins score. In certain cases it is difficult to cross mitral valve (MV) either due to dilated left atrium (LA), low septal puncture, or severe mitral valvular and subvalvular stenosis leading to prolonged procedure time or failure of PTMC procedure...
April 2018: Journal of Cardiology Cases
Mónika Meilinger-Dobra, Éva Remenár, Georgina Fröhlich, István Sinkovics, Ilona Péter, András Boér
The standard treatment of papillary microcarcinomas (mPTC; ≤1 cm) regardless of their size, was similar to the advanced ones till the recent past: immediate surgery ± radioactive iodine (RAI) therapy. However, the American Thyroid Association (ATA) 2015 guidelines accept the active surveillance in selected cases. We performed a retrospective analysis on the clinical data of 103 patients with PTmC in a single (62.1%) or multiple nodes (37.9%), treated with immediate surgery followed in most cases by postoperative RAI between 2001 and 2010...
September 26, 2018: Magyar Onkologia
Wen-Xu Jin, Dan-Rong Ye, Yi-Han Sun, Xiao-Fen Zhou, Ou-Chen Wang, Xiao-Hua Zhang, Ye-Feng Cai
Background: Preoperative diagnosis of central lymph node metastasis (CLNM) poses to be a challenge in clinical node-negative papillary thyroid microcarcinoma (PTMC). This research work aims at investigating the association existing between BRAF mutation, clinicopathological factors, ultrasound characteristics, and CLNM, in addition to establishing a predictive model for CLNM in PTMC. Materials and methods: The study included 673 PTMC patients, already undergone total thyroidectomy or lobectomy with prophylactic central lymph node dissection...
2018: Cancer Management and Research
Hye-Seon Oh, Jeonghoon Ha, Hye In Kim, Tae Hyuk Kim, Won Gu Kim, Dong-Jun Lim, Tae Yong Kim, Sun Wook Kim, Won Bae Kim, Young Kee Shong, Jae Hoon Chung, Jung Hwan Baek
BACKGROUND: Active surveillance has been introduced as a management option for low-risk papillary thyroid microcarcinoma (PTMC) due to its mostly indolent course. METHODS: This was a multicenter study of 370 PTMC patients who underwent active surveillance more than one year. The changes in volume and maximum diameter between initial and last ultrasonography were evaluated to identify the natural course of PTMC during active surveillance. RESULTS: Patients' age at diagnosis was 51 ± 12 years, and 110 (30%) patients were <45 years of age...
October 17, 2018: Thyroid: Official Journal of the American Thyroid Association
Jung Bum Choi, Woo Kyung Lee, Seul Gi Lee, Haengrang Ryu, Cho Rok Lee, Sang Wook Kang, Jong Ju Jeong, Kee-Hyun Nam, Eun Jig Lee, Woong Youn Chung, Young Suk Jo, Jandee Lee
Purpose: Active surveillance (AS) of low-risk papillary thyroid microcarcinoma (PTMC) may reduce the risk of overtreatment of clinically insignificant cancer. However, the absence of predictor for the progression of PTMC resulted in treatment delay and potentially compromising cure of aggressive disease. Therefore, to anticipate potential damage of delayed surgery, we investigated the oncologic outcomes of patients with low-risk PTMC initially eligible for AS except clinically apparent lymph node metastasis (LNM), imitating delayed surgery with neck dissection...
2018: Cancer Management and Research
Khurram Shafique, Virginia A LiVolsi, Kathleen Montone, Zubair W Baloch
Papillary thyroid microcarcinoma (PTMC) accounts for nearly 50% of newly diagnosed PTC cases. There is considerable debate in literature about the clinicopathologic features and prognostic significance of PTMC and whether it should be treated as a separate entity. Due to lack of agreement and supportive data, the consensus study group that established the criteria for non-invasive thyroid neoplasm with papillary-like features (NIFTP) kept its size above 1 cm i.e., excluding PTMC from this new group. As a result, to date, some patients diagnosed with PTMC get aggressive treatments such as partial or total thyroidectomy and even radioactive iodine ablation...
December 2018: Endocrine Pathology
Young Chan Lee, Ah Ra Jung, Yu-Mee Sohn, Eui-Jong Kim, Young-Gyu Eun
PURPOSE: To assess the ultrasonographic features affect accuracy of extrathyroid extension (ETE) evaluation on preoperative ultrasonography (US) in papillary thyroid microcarcinoma (PTMC). METHODS: Of the total patients who underwent thyroid surgery, 516 patients with a tumor measuring less than 1 cm on preoperative US were enrolled in this study. One blinded head and neck radiologist reviewed the preoperative US images to evaluate the US features of PTMC, and the pathologic reports were reviewed...
November 2018: European Archives of Oto-rhino-laryngology
Chandra Mani Adhikari, Rabi Malla, Raamesh Koirala, Dipanker Prajapati, Navin Gautam
MV repair in the rheumatic population is feasible with acceptable long-term results. Incidence of mitral stenosis (MS) following mitral valve (MV) repair for severe rheumatic mitral regurgitation (MR) and usefulness of percutaneous transluminal mitral valvuloplasty in these patients is not described in literature. We report a case of successful PTMC in severe MS following MV repair for severe rheumatic MR.
June 2018: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
Wuping Zheng, Jingtai Li, Pengfei Lv, Zhilin Chen, Pingming Fan
INTRODUCTION: This systemic review and meta-analysis was to determine whether the recurrence and mortality rates in papillary thyroid microcarcinoma (PTMC) patients were lower when treated with total thyroidectomy (TT) compared to thyroid lobectomy (TL). METHODS: Using PubMed, Cochrane library and EMBASE databases, we conducted a meta-analysis to assess the clinical outcomes in patients with PTMC based on surgical mode. The relative risk (RR) and 95% confidence interval (CI) were calculated for this meta-analysis...
November 2018: European Journal of Surgical Oncology
F Du, S Hu, C Wu, Y Cheng, L X Wu, J Z Liu, Z F Wu, S J Li
Objective: To investigate the influential factors of efficacy of the first (131)I ablation therapy for thyroid remnant in papillary thyroid microcarcinoma (PTMC) patients after thyroidectomy. Methods: Eighty-nine PTMC patients who underwent twice (131)I ablation therapy and (131)I whole body follow-up scan ((131)I-WBS) within 5 to 8 months in our department from September 2007 to October 2016 were identified and enrolled in present study. Patients were divided into complete-ablation group and uncomplete-ablation group according to whether or not radioactivity was detected at the thyroid bed in (131)I-WBS...
August 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Xi Zhang, Li Zhang, Shuai Xue, Peisong Wang, Guang Chen
BACKGROUND: Solitary papillary thyroid microcarcinoma (PTMC) without gross extrathyroidal extension (ETE) were the main candidates for active surveillance (AS). Predictive factors of lateral lymph node metastasis (LLNM) in solitary PTMC without gross ETE were essential but still unknown. METHODS: Altogether, 171 patients of solitary PTMC without gross ETE were enrolled in our study and divided into two groups. Group A: 123 patients without lateral lymph node dissection (LLND) were considered to be LLNM negative because there was no lateral recurrence by at least 8-year follow up for all patients...
August 3, 2018: Asian Journal of Surgery
Zeming Liu, Qiuyang Zhao, Chunping Liu, Wen Zeng, Jie Ming, Chen Chen, Shuntao Wang, Yiquan Xiong, Chao Zhang, Tianwen Chen, Tao Huang, Liang Guo
The treatment of papillary thyroid microcarcinoma (PTMC) remains deeply controversial. In this study, we investigated the prognosis of patients who underwent biopsy alone, as compared with other forms of thyroidectomy approaches. We sought to provide reference information for treatment selection in cases of PTMC.The analysis included a large cohort of 34,972 PTMC patients from the Surveillance, Epidemiology, and End Results (SEER) database between 2004 and 2013. Survival was examined by Kaplan-Meier analyses with log-rank tests, Cox proportional-hazards regression analyses, and propensity score matching analyses...
August 2018: Medicine (Baltimore)
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