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congenital heart disease pediatric

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https://www.readbyqxmd.com/read/29912937/comparison-of-three-non-invasive-hemodynamic-monitoring-methods-in-critically-ill-children
#1
Chanapai Chaiyakulsil, Marut Chantra, Poomiporn Katanyuwong, Anant Khositseth, Nattachai Anantasit
INTRODUCTION: Hemodynamic parameters measurements were widely conducted using pulmonary artery catheter (PAC) with thermodilution as a reference standard. Due to its technical difficulties in children, transthoracic echocardiography (TTE) has been widely employed instead. Nonetheless, TTE requires expertise and is time-consuming. Noninvasive cardiac output monitoring such as ultrasonic cardiac output monitor (USCOM) and electrical velocimetry (EV) can be performed rapidly with less expertise requirement...
2018: PloS One
https://www.readbyqxmd.com/read/29912067/rbc-exposure-in-pediatric-extracorporeal-membrane-oxygenation-epidemiology-and-factors-associated-with-large-blood-transfusion-volume
#2
Conor P O'Halloran, Peta M A Alexander, Kristofer G Andren, Jessica Mecklosky, Joshua W Salvin, Stephanie Larsen, Jill Zalieckas, Francis Fynn-Thompson, Ravi R Thiagarajan
OBJECTIVES: To quantify and identify factors associated with large RBC exposure in children supported with extracorporeal membrane oxygenation. DESIGN: Retrospective cohort study. SETTING: Single tertiary care children's hospital. PATIENTS: One-hundred twenty-two children supported with extracorporeal membrane oxygenation for greater than 12 hours during January 1, 2015, to December 31, 2016. INTERVENTIONS: None...
June 14, 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29910579/bedside-ultrasonography-screening-for-congenital-renal-anomalies-in-children-with-congenital-heart-diseases-undergoing-cardiac-repair
#3
Hussam K Hamadah, Omar Hijazi, Mohammad A Faraji, Mohamed S Kabbani
Introduction: Ultrasound (US) assessment of renal anomalies in children requiring pediatric cardiac surgery is not a standard practice. This study is highlighting the role of bedside US performed by intensivist to detect occult renal anomalies associated with congenital heart disease (CHD). Methods: A cross sectional study for 100 consecutive children with CHD admitted to Pediatric Cardiac Intensive Care Unit (PCICU) in 2015. US of kidneys screening was performed by trained pediatric cardiac intensivists to ascertain the presence of both kidneys in renal fossae without gross anomalies and to investigate if early detection of occult kidney anomaly would have any impact on outcome...
April 2018: Journal of the Saudi Heart Association
https://www.readbyqxmd.com/read/29908725/validation-and-reference-values-for-three-dimensional-echocardiographic-right-ventricular-volumetry-in-children-a-multicenter-study
#4
Kai Thorsten Laser, Ayşe Karabiyik, Hermann Körperich, Jan-Pit Horst, Peter Barth, Deniz Kececioglu, Wolfgang Burchert, Robert DallaPozza, Ulrike Herberg
BACKGROUND: Functional assessment of the right ventricle using real-time three-dimensional echocardiography (RT3DE) has fundamental relevance in young patients with congenital heart disease. Reference values for the pediatric population are scarce. This multicenter study was designed to (1) validate new evaluation software for RT3DE and (2) establish pediatric reference values. METHODS: For validation, right ventricular (RV) end-diastolic volume (EDV) and end-systolic volume (ESV) were determined from real-time three-dimensional echocardiographic data sets of 38 subjects (n = 17 healthy individuals and n = 21 patients with congenital heart disease) using new dedicated evaluation software (RV-Function 2...
June 13, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29908036/acquired-von-willebrand-syndrome-in-congenital-heart-disease-surgery-results-from-an-observational-case-series
#5
Vanya Icheva, Martina Nowak-Machen, Ulrich Budde, Karl Jaschonek, Felix Neunhoeffer, Matthias Kumpf, Michael Hofbeck, Christian Schlensak, Gesa Wiegand
BACKGROUND: Cardiac surgery of the newborn and infant with complex congenital heart disease (CHD) is associated with a high rate of intraoperative bleeding complications. CHD-related anatomic features such as valve stenoses or patent arterial ducts can lead to enhanced shear stress in blood stream and thus cause acquired von Willebrand syndrome (aVWS). OBJECTIVE: To evaluate the intraoperative incidence and impact of aVWS after cardiopulmonary bypass (CPB) in neonates and infants with complex CHD...
June 16, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29899389/calcitriol-trend-following-pediatric-cardiac-surgery-and-association-with-clinical-outcome
#6
Nina Acharya, Dermot R Doherty, Nick Barrowman, Gyaandeo Maharajh, Tara Girolamo, Katie O'Hearn, J Dayre McNally
BACKGROUND: Consistent with accepted practice in stable ambulatory populations, the majority of ICU research has evaluated vitamin D status using a single blood 25-hydroxyvitamin D (25(OH)D) level. Only a limited number of ICU studies have measured the active hormone, 1,25-dihydroxyvitamin D (calcitriol) and none have used change in calcitriol levels to evaluate axis functioning. The objective of this study was to describe the impact of Congenital Heart Disease (CHD) surgery on calcitriol levels and evaluate the relationship between change in postoperative levels and clinical course...
June 13, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29895303/isolated-right-superior-vena-cava-draining-into-the-left-atrium-in-a-child-with-vein-of-galen-aneurysmal-malformation-case-report
#7
Ahmed F Elmahrouk, Abdelmonem Helal, Mohamed F Ismail, Tamer Hamouda, Mohammed Mashali, Ahmed A Jamjoom, Jameel A Al-Ata
BACKGROUND: Isolated right Superior Vena Cava drainage into the left atrium in the absence of other cardiac anomalies is an extremely rare condition. The vein of Galen aneurysmal malformation is a congenital vascular malformation. It comprises 1% of all pediatric congenital anomalies. The association vein of Galen aneurysmal malformation, with congenital heart disease has been described. CASE PRESENTATION: We describe a 16-months old toddler presenting at 7-months of age with respiratory distress and cyanosis...
June 13, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29886666/-techniques-and-experience-which-improve-the-surgical-outcomes-of-critical-and-complex-congenital-heart-disease-in-neonates
#8
Y Pan, B Jia
Objective: To discuss the experience of early surgical intervention to critical and complex congenital heart diseases (CHD) in neonates. Methods: A retrospective study of clinical records of patients with congenital heart diseases underwent surgical intervention in one single pediatric cardiac center was performed. From January 2009 to December 2017, 841 critical and complex CHD neonates were identified at Department of Cardiovascular Surgery, Children's Hospital of Fudan University, of which 6.5% were premature...
June 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29883655/pediatric-coronary-artery-bypass-surgery-for-congenital-heart-disease
#9
REVIEW
Soichiro Kitamura
BACKGROUND: Pediatric coronary artery bypass surgery (PCABS) for congenital heart disease has become increasingly important in infants and children undergoing modern cardiac surgery, because of its life-saving potential in unsuccessful coronary transfer surgery. This review summarizes the current surgical role of PCABS for treating congenital heart diseases. METHODS: Databases, mainly PUBMED, were searched for relevant publications regarding coronary bypass surgery in the pediatric population, from 1970 (commencement) to March 2018...
June 5, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29882346/efficacy-of-prophylactic-dexmedetomidine-in-preventing-postoperative-junctional-ectopic-tachycardia-in-pediatric-cardiac-surgery-patients-a-systematic-review-and-meta-analysis
#10
REVIEW
Laxmi V Ghimire, Fu-Sheng Chou
BACKGROUND: Junctional ectopic tachycardia is a serious tachyarrhythmic complication following pediatric cardiac surgery. It is difficult to manage and is associated with significant morbidity and mortality. Conventional nonpharmacological and pharmacological measures have shown limited effects. Dexmedetomidine is an α2 agonist which has recently been shown in multiple studies to be effective. AIMS: The aim of this systematic review with meta-analysis was to evaluate the efficacy of prophylactic dexmedetomidine administration in the prevention of junctional ectopic tachycardia in pediatric patients following cardiac surgeries...
June 7, 2018: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/29878688/comparison-of-basiliximab-vs-antithymocyte-globulin-for-induction-in-pediatric-heart-transplant-recipients-an-analysis-of-the-international-society-for-heart-and-lung-transplantation-database
#11
Ryan J Butts, Anne I Dipchand, David Sutcliffe, Maria Bano, Vivian Dimas, Robert Morrow, Bibhuti Das, Richard Kirk
This study aims to compare 2 common induction strategies, basiliximab and ATG. Analysis of the ISHLT transplant registry was performed. The database was queried for pediatric heart transplants from January 1, 2000, to June 30, 2015, who had received induction with basiliximab or ATG. Primary end-point was graft survival. Secondary end-points included 1-year survival and 1-year conditional survival. There were 3158 heart transplants who received induction with basiliximab or ATG. The ATG cohort was younger, more likely to have congenital heart disease or be a retransplant, have a higher PRA, longer ischemic time, and been transplanted earlier in the study period (all P<...
June 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29872881/postoperative-obstruction-of-the-pulmonary-veins-in-mixed-total-anomalous-pulmonary-venous-connection
#12
Deborah Y Ho, Brian R White, Andrew C Glatz, Christopher E Mascio, Paul Stephens, Meryl S Cohen
Total anomalous pulmonary venous connection (TAPVC) is a rare form of congenital heart disease in which the pulmonary veins drain by various pathways to the right atrium instead of the left atrium. Postoperative obstruction of the pulmonary veins is a known complication. Identifying risk factors for morbidity and mortality is important for counseling and monitoring. We describe a pattern of postoperative obstruction in a specific arrangement of mixed TAPVC. Five patients with a type of mixed TAPVC, namely, three pulmonary veins connecting to the coronary sinus and the left upper pulmonary vein (LUPV) connecting to the innominate vein, were identified over an 11-year period at our institution...
June 5, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29862662/risk-factor-analysis-for-mortality-among-infants-requiring-tracheostomy
#13
Abigail R Strang, Jenna W Briddell, Patrick C Barth, Udayan K Shah, Aaron Chidekel
INTRODUCTION: An increasing number of tracheostomies are performed in infants with complex comorbidities including bronchopulmonary dysplasia (BPD) and congenital heart disease (CHD). With this shift in indications, there is an urgent need to characterize outcomes in this population. METHODS: This 5-year retrospective chart review assessed rates of 12-month mortality in infants who were ≤12 months of age at the time of tracheostomy at a tertiary care pediatric hospital and risk factors associated with death...
June 3, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29858197/supporting-optimal-neurodevelopmental-outcomes-in-infants-and-children-with-congenital-heart-disease
#14
Jennifer K Peterson
Improved survival has led to increased recognition of developmental delays in infants and children with congenital heart disease. Risk factors for developmental delays in congenital heart disease survivors may not be modifiable; therefore, it is important that lifesaving, high-technology critical care interventions be combined with nursing interventions that are also developmentally supportive. Implementing developmental care in a pediatric cardiac intensive care unit requires change implementation strategies and widespread support from all levels of health care professionals...
June 2018: Critical Care Nurse
https://www.readbyqxmd.com/read/29845954/early-neurodevelopmental-outcomes-after-corrective-cardiac-surgery-in-infants
#15
Ritchie Sharon Solomon, Tanuja Sasi, Abish Sudhakar, Raman Krishna Kumar, Balu Vaidyanathan
OBJECTIVE: To assess neurodevelopmental status in Indian infants undergoing corrective surgery for congenital heart disease (CHD) and to analyze factors associated with neurodevelopmental delay. DESIGN: Cross-sectional study. SETTING: Tertiary-care pediatric cardiology facility. PARTICIPANTS: Consecutive infants undergoing corrective surgery for CHD (January 2013 -December 2014). Palliative procedures, and patients with known genetic syndromes were excluded...
May 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29844139/safety-of-oral-propranolol-for-infantile-hemangioma
#16
Catherine Droitcourt, Sandrine Kerbrat, Caroline Rault, Marie-Anne Botrel, André Happe, Ronan Garlantezec, Bernard Guillot, Jean-Marc Schleich, Emmanuel Oger, Alain Dupuy
OBJECTIVES: The safety of oral propranolol for infantile hemangioma has not yet been studied at population level since the pediatric use marketing authorization was obtained in Europe. METHODS: A survey of a nationwide, claim-based observational cohort of children <3 years old, with at least 1 delivery of oral propranolol between July 2014 and June 2016, was performed by using the database of the French National Health Insurance system. Standardized morbidity ratios (SMRs) were calculated by using, from the same database, a representative random sample of nonexposed subjects...
May 29, 2018: Pediatrics
https://www.readbyqxmd.com/read/29808135/uncommon-infections-in-children-suggest-underlying-immunodeficiency-a-case-of-infective-endocarditis-in-a-3-year-old-male
#17
Aisha Shakoor, Ahmed El-Isa, Elizabeth Kinsella, Ryan Halas, Andrey Leonov
Infective endocarditis (IE) results from bacterial or fungal infection and is associated with significant morbidity and mortality. Several known risk factors exist for endocarditis, and 90% of pediatric cases have an underlying structural or congenital heart disease or prosthetic heart valve. Literature on IE in previously healthy children is relatively sparse, and the pathogenesis and underlying risk factors remain mostly unknown. Our patient was a 3-year-old male with a unique presentation of IE. His lack of structural and congenital risk factors for endocarditis prompted further workup, and labs were consistent with insufficient immunoglobulin, suggesting a primary immunodeficiency (PAD)...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29807773/preclinical-performance-of-a-pediatric-mechanical-circulatory-support-device-the-pediaflow-ventricular-assist-device
#18
Salim E Olia, Peter D Wearden, Timothy M Maul, Venkat Shankarraman, Ergin Kocyildirim, Shaun T Snyder, Patrick M Callahan, Marina V Kameneva, William R Wagner, Harvey S Borovetz, James F Antaki
OBJECTIVES: The PediaFlow (HeartWare International, Inc, Framingham, Mass) is a miniature, implantable, rotodynamic, fully magnetically levitated, continuous-flow pediatric ventricular assist device. The fourth-generation PediaFlow was evaluated in vitro and in vivo to characterize performance and biocompatibility. METHODS: Supported by 2 National Heart, Lung, and Blood Institute contract initiatives to address the limited options available for pediatric patients with congenital or acquired cardiac disease, the PediaFlow was developed with the intent to provide chronic cardiac support for infants as small as 3 kg...
April 21, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29799947/association-between-early-postoperative-acetaminophen-exposure-and-acute-kidney-injury-in-pediatric-patients-undergoing-cardiac-surgery
#19
Sara L Van Driest, Edmund H Jooste, Yaping Shi, Leena Choi, Leon Darghosian, Kevin D Hill, Andrew H Smith, Prince J Kannankeril, Dan M Roden, Lorraine B Ware
Importance: Acute kidney injury (AKI) is a common and serious complication for pediatric cardiac surgery patients associated with increased morbidity, mortality, and length of stay. Current strategies focus on risk reduction and early identification because there are no known preventive or therapeutic agents. Cardiac surgery and cardiopulmonary bypass lyse erythrocytes, releasing free hemoglobin and contributing to oxidative injury. Acetaminophen may prevent AKI by reducing the oxidation state of free hemoglobin...
May 14, 2018: JAMA Pediatrics
https://www.readbyqxmd.com/read/29798687/thrombotic-storm-in-a-4-year-old-boy-with-a-thrombus-in-the-right-atrium
#20
Jing-Yao Ma, Xin Zhang, Xiao-Feng Li, Le-Jian He, Ning Ma, Yun-Yun Wei, Run-Hui Wu, Fang-Yun Wang
Thrombotic storm (TS) is a rare disease, especially with thrombus in the heart of pediatric patient. We present a case of a 4-year-old boy, who was diagnosed with TS during his first hospitalization due to lower extremity deep venous thrombosis, pulmonary embolism, and thrombosis of the inferior vena cava, cerebral, left internal jugular, portal, renal, and iliac veins. He was eventually prescribed with rivaroxaban to control thrombosis after 30 days of successive use of low-molecular-weight heparin, unfractionated heparin, and warfarin, which were demonstrating little effect on preventing thrombosis, and the patient was intolerant to argatroban...
January 2018: International Journal of Immunopathology and Pharmacology
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