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https://www.readbyqxmd.com/read/29219053/triazolopyrimidines-and-thiazolopyrimidines-synthesis-anti-hsv-1-cytotoxicity-and-mechanism-of-action
#1
Salwa F Mohamed, Eman M H Abbas, Hemat S Khalaf, Thoraya A Farghaly, Dina N Abd El-Shafy
Merged pyrimidine derivatives were designed by one pot synthesis of pyrimidinethione derivative with halogenated compounds. The structure of all prepared compounds was characterized by their spectroscopic data and also, their ability to inhibit the in vitro replication of HSV-1 was estimated. Amongst the tested compounds 2-acetyl-3-methyl-5-(p-tolyl)indeno[1,2-d]thiazolo[3,2-a]pyrimidin-6(5H)-one (9b) and ethyl 3-methyl-6-oxo-5-(p-tolyl)-5,6-dihydroindeno[1,2-d]thiazolo[3,2-a]pyrimidine-2-carboxylate (9c), caused viral inhibition over 90%...
December 7, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29219012/significance-of-assay-of-nucleated-rbcs-in-umbilical-cord-blood-in-neonates-with-meconium-stained-amniotic-fluid
#2
M Elsokkary, A Mamdouh, W Nossair, O Abd El Fattah, H Hemeda, S Sallam, M Taema, M Hussain, A Shafik, M Nawara, M Samy, M Abd El Aleem, R Abdelhadi, N Sakna, A Salama, D Salama, O El-Tohamy, N Elsaid
BACKGROUND: Approximately 8-15% of all infants are born with evidence of meconium-stained amniotic fluid (MSAF). MSAF is a potentially serious sign of fetal compromise and may indicate fetal hypoxia Objectives and aim of the work: The present study was designed to evaluate the relationship between meconium stained amniotic fluid and fetal nucleated red blood cell counts. As well, we aim to evaluate the relationship between the presence of meconium in amniotic fluid and Apgar scores in neonates...
December 8, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29218742/prevalence-of-foot-disorders-in-captive-sardinian-partridges-alectoris-barbara-barbara-bonnaterre-1790-as-useful-indicators-of-fitness-to-natural-environment
#3
M G Cappai, A Abd El-Wahab, G Arru, M Muzzeddu, W Pinna
Foot health represents an issue in wild avifauna breeding practices. In particular, prevalence of digital ulceration (DU) and foot pad dermatitis (FPD) are valid indicators of welfare in wildlife conservation centres and may be interpreted as to fitness for bird's reintroduction into the wild. This study meant to test the effects of raising practices on foot pad health in captive Sardinian partridges (Alectoris barbara barbara Bonnaterre, 1790) reared for biodiversity conservation, to assess welfare and fitness to reintroduction into nature...
December 8, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29217030/perforated-punctal-plugs-with-adjuvant-use-of-mitomycin-c-in-management-of-acquired-external-punctal-stenosis-grades-0-and-1
#4
Ayman S Abd El Ghafar, Amr M El-Kannishy, Mohamed M Elwan, Dalia Sabry, Hanem M Kishk, Eman M Elhefney
OBJECTIVE: To evaluate the use of perforated punctal plugs with adjuvant application of mitomycin-C in the management of acquired external punctal stenosis grades 0 and 1. METHODS: This is a prospective interventional case series including 30 eyes of 30 patients with acquired external punctal stenosis of the lower punctum of grades 0 and 1 presenting with epiphora. They were examined to exclude other causes of lacrimation and epiphora: Slit-lamp assessment of the stenosed punctum and grading was done, probing was done to exclude associated canalicular stenosis, and syringing was done to exclude nasolacrimal duct obstruction...
December 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29216380/recent-advances-in-intradural-spinal-tumors
#5
Muhammad M Abd-El-Barr, Kevin T Huang, Ziev B Moses, J Bryan Iorgulescu, John H Chi
Intradural spinal tumors are rare tumors of the central nervous system. Due to the eloquence of the spinal cord and its tracts, compact architecture of the cord and nerves and the infiltrative nature of some of these tumors, surgical resection is difficult to achieve without causing neurological deficits. Likewise, chemotherapy and radiotherapy are utilized more cautiously in the treatment of intradural spinal tumors than their cranial counterparts. Targeted therapies aimed at the genetic alterations and molecular biology tailored to these tumors would be helpful, but are lacking...
December 5, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29216030/update-influenza-activity-united-states-october-1-november-25-2017
#6
Vivien G Dugan, Lenee Blanton, Anwar Isa Abd Elal, Noreen Alabi, John Barnes, Lynnette Brammer, Erin Burns, Charisse N Cummings, Todd Davis, Brendan Flannery, Alicia M Fry, Shikha Garg, Rebecca Garten, Larisa Gubareva, Yunho Jang, Krista Kniss, Natalie Kramer, Stephen Lindstrom, Desiree Mustaquim, Alissa O'Halloran, Sonja J Olsen, Wendy Sessions, Calli Taylor, Susan Trock, Xiyan Xu, David E Wentworth, Jacqueline Katz, Daniel Jernigan
Influenza activity in the United States was low during October 2017, but has been increasing since the beginning of November. Influenza A viruses have been most commonly identified, with influenza A(H3N2) viruses predominating. Several influenza activity indicators were higher than is typically seen for this time of year. The majority of influenza viruses characterized during this period were genetically or antigenically similar to the 2017-18 Northern Hemisphere cell-grown vaccine reference viruses. These data indicate that currently circulating viruses have not undergone significant antigenic drift; however, circulating A(H3N2) viruses are antigenically less similar to egg-grown A(H3N2) viruses used for producing the majority of influenza vaccines in the United States...
December 8, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29215080/risk-predictors-and-outcomes-of-acute-kidney-injury-in-patients-admitted-to-intensive-care-units-in-egypt
#7
Samar Abd ElHafeez, Giovanni Tripepi, Robert Quinn, Yasmine Naga, Sherif Abdelmonem, Mohamed AbdelHady, Ping Liu, Matthew James, Carmine Zoccali, Pietro Ravani
Epidemiology of acute kidney injury (AKI) in developing countries is under-studied. We evaluated the risk and prognosis of AKI in patients admitted to intensive care units (ICUs) in Egypt. We recruited consecutive adults admitted to ICUs in Alexandria Teaching Hospitals over six months. We used the KDIGO criteria for AKI. We followed participants until the earliest of ICU discharge, death, day 30 from entry or study end. Of the 532 participants (median age 45 (Interquartile range [IQR]: 30-62) years, 41.7% male, 23...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29214857/feeding-time-can-alleviate-negative-effects-of-heat-stress-on-performance-meat-quality-and-health-status-of-turkey
#8
M F A Farghly, M Alagawany, M E Abd El-Hack
1. A total of 180 one-day-old chickens were randomly assigned to 6 equal groups to investigate the effect of feeding time on growth performance, carcass characteristics, meat quality, leg problems and physiological responses of growing turkeys under the high temperature conditions of summer. 2. Birds of the first group were ad libitum fed and were considered as the controls (C). The second group (T1) was given 80% of diet in the morning and 20% of diet in the afternoon, The third group (T2) was given 60% of diet in the morning and 40% of diet in the afternoon, The fourth group (T3) was given 40% of diet in the morning and 60% of diet in the afternoon, The fifth group (T4) was given 20% of diet in the morning and 80% of diet in the afternoon and the sixth group (T5) was given 100% of diet in the afternoon...
December 7, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29214477/prevalence-of-occult-hepatitis-c-virus-among-hemodialysis-patients-in-tanta-university-hospitals-a-single-center-study
#9
Ghada Abdelmoemen, Samy Abdelkader Khodeir, Sabry Abou-Saif, Abdelrahman Kobtan, Sherief Abd-Elsalam
Occult hepatitis C virus infection (OCI) is a newly defined type of infection by the chronic hepatitis virus (HCV) distinguished by the existence of HCV RNA in liver tissue and/or peripheral blood mononuclear cells (PBMCs) in patients whose plasma are devoid of both positive serology and RNA. Patients on maintenance hemodialysis evince a higher HCV prevalence than the general population due to high nosocomial transmission by the dialysis units. We investigated the prevalence of occult HCV infection in patients attending our university hemodialysis centers for maintenance hemodialysis...
December 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29210317/enhanced-ocular-bioavailability-of-fluconazole-from-niosomal-gels-and-microemulsions-formulation-optimization-and-in-vitro-in-vivo-evaluation
#10
Osama Abd El-Aazeem Soliman, Elham Abdel Monem Mohamed, Nabil Abdullah Ali Khatera
Fungal keratitis may cause vision loss if it is not treated. Methods other than ocular delivery exhibited several limitations. No previous studies investigated and compared ocular bioavailability of fluconazole (FLZ) from niosomal gels and microemulsions. Niosomal gels of FLZ (0.3% w/w) based on Span® 60 and cholesterol (CH) using 1% w/w carbopol® 934 (CP) were evaluated. FLZ microemulsions (0.3% w/v) containing isopropyl myristate (IPM, as oil phase) and a 3:1 mixture of Tween® 80 (as surfactant) and polyethylene glycol 400 (PEG 400, as cosurfactant) were characterized...
December 6, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29209979/genotoxicity-assessment-of-raw-and-treated-water-samples-using-allium-cepa-assay-evidence-from-perak-river-malaysia
#11
Amirhossein Malakahmad, Teh Sabariah Binti Abd Manan, Subarna Sivapalan, Taimur Khan
Allium cepa assay was carried out in this study to evaluate genotoxic effects of raw and treated water samples from Perak River in Perak state, Malaysia. Samples were collected from three surface water treatment plants along the river, namely WTPP, WTPS, and WTPK. Initially, triplicates of equal size Allium cepa (onions) bulbs, 25-30 mm in diameter and average weight of 20 g, were set up in distilled water for 24 h at 20 ± 2 °C and protected from direct sunlight, to let the roots to grow. After germination of roots (0...
December 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29208080/selective-determination-of-diazinon-and-chlorpyrifos-in-the-presence-of-their-degradation-products-application-to-environmental-samples
#12
Mamdouh R Rezk, Abd El-Aziz B Abd El-Aleem, Shaban M Khalile, Omneya K El-Naggar
An accurate, sensitive, and selective HPLC method was developed and validated for the determination of diazinon and chlorpyrifos. These pesticides were subjected to different stress conditions, such as acidic, alkaline, oxidative, thermal, and photolytic hydrolysis. The proposed method used a C18 Eclipse Plus column (100 × 4.6 mm, 3.5 µm) and a mobile phase consisting of acetonitrile–water (70 + 30, v/v) in an isocratic separation mode. The flow rate was 1.5 mL/min, with UV detection at 247 and 230 nm for diazinon and chlorpyrifos, respectively...
December 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29206567/comparison-of-robotic-pyeloplasty-and-standard-laparoscopic-pyeloplasty-in-infants-a-bi-institutional-study
#13
Amos Neheman, Eyal Kord, Amnon Zisman, Abd Elhalim Darawsha, Paul H Noh
PURPOSE: To compare outcomes between robotic pyeloplasty (RP) and standard laparoscopic pyeloplasty (LP) in the infant population for the treatment of ureteropelvic junction (UPJ) obstruction. MATERIALS AND METHODS: We performed a retrospective cohort study of all children under 1 year of age who underwent RP or LP at two different medical centers between October 2009 and February 2016. Patient demographics, perioperative data, complications, and results were reviewed...
December 5, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29204733/comparative-nutritional-and-mycochemical-contents-biological-activities-and-lc-ms-screening-of-tuber-from-new-recipe-cultivation-technique-with-wild-type-tuber-of-tiger-s-milk-mushroom-of-species-lignosus-rhinocerus
#14
Nor Azreen Mohd Jamil, Noraswati Mohd Nor Rashid, Mohamad Hasril Abd Hamid, Norasfaliza Rahmad, Jameel R Al-Obaidi
Tiger's milk mushroom is known for its valuable medicinal properties, especially the tuber part. However, wild tuber is very hard to obtain as it grows underground. This study first aimed to cultivate tiger's milk mushroom tuber through a cultivation technique, and second to compare nutritional and mycochemical contents, antioxidant and cytotoxic activities and compound screening of the cultivated tuber with the wild tuber. Results showed an increase in carbohydrate content by 45.81% and protein content by 123...
December 4, 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/29201296/predictors-of-midterm-outcomes-after-medial-unicompartmental-knee-arthroplasty-in-asians
#15
Hamid Rahmatullah Bin Abd Razak, Sanchalika Acharyya, Shi-Ming Tan, Hee-Nee Pang, Keng-Jin Darren Tay, Shi-Lu Chia, Ngai-Nung Lo, Seng-Jin Yeo
Background: This study was designed to evaluate predictors of good outcomes following medial unicompartmental knee arthroplasty (UKA) in Asian patients. Methods: Registry data of patients who underwent primary unilateral medial UKA from 2006 to 2011 were collected. Outcomes studied were the Oxford Knee Score (OKS) and the Physical Component Score (PCS) of the Short Form 36 (SF-36) questionnaire. These outcome scores were collected prospectively, pre- and postoperatively up to 5 years...
December 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29201276/antihypertensive-effects-of-roselle-olive-combination-in-l-name-induced-hypertensive-rats
#16
Rehab F Abdel-Rahman, Alyaa F Hessin, Marwan Abdelbaset, Hanan A Ogaly, Reham M Abd-Elsalam, Salah M Hassan
This study aimed to evaluate the antihypertensive efficacy of a new combination therapy of Hibiscus sabdariffa and Olea europaea extracts (2 : 1; Roselle-Olive), using N(G)-nitro-L-arginine-methyl ester- (L-NAME-) induced hypertensive model. Rats received L-NAME (50 mg/kg/day, orally) for 4 weeks. Concurrent treatment with Roselle-Olive (500, 250, and 125 mg/kg/day for 4 weeks) resulted in a dose-dependent decrease in both systolic and diastolic blood pressure, reversed the L-NAME-induced suppression in serum nitric oxide (NO), and improved liver and kidney markers, lipid profile, and oxidative status...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29200916/study-on-tullbergiidae-of-tibet-china-i-metaphorura-mesaphorura-and-prabhergia-hexapoda-collembola
#17
Yun Bu, Yan Gao
The Tullbergiidae of Tibet is studied for the first time and the genus Metaphorura Bagnall, 1936 is firstly recorded in China. Metaphorura motuoensissp. n. from southeastern Tibet is described and illustrated. It is characterized by the presence of 1+1 pseudocelli on thoracic segment I, few vesicles (14 -16) on PAO, pseudocellar formula as 11/111/11111, all pseudocelli of type II, setae p4 on abdominal segment V as microsetae, weakly differentiated sensory seta p3 on abdominal segment V, absence of median process on Abd VI...
2017: ZooKeys
https://www.readbyqxmd.com/read/29200826/anticancer-effect-of-dentatin-and-dentatin-hydroxypropyl-%C3%AE-cyclodextrin-complex-on-human-colon-cancer-ht-29-cell-line
#18
Ashwaq Shakir Al-Abboodi, Abdullah Rasedee, Ahmad Bustamam Abdul, Yun Hin Taufiq-Yap, Wafaa Abd Alwahed Alkaby, Mostafa Saddam Ghaji, Peter M Waziri, Mothanna Sadiq Al-Qubaisi
Introduction: Dentatin (DEN) (5-methoxy-2, 2-dimethyl-10-(1, 1-dimethyl-2propenyl) dipyran-2-one), a natural compound present in the roots of Clausena excavata Burm f, possesses pro-apoptotic and antiproliferative effects in various cancer cells. Because of its hydrophobicity, it is believed that its complexation with hydroxy-β-cyclodextrin (HPβCD) will make it a potent inhibitor of cancer cell growth. In the current work, the molecular mechanisms of apoptosis induced by DEN and DEN-HPβCD complex were demonstrated in human colon HT-29 cancer cells...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29200721/helichrysetin-induces-dna-damage-that-triggers-jnk-mediated-apoptosis-in-ca-ski-cells
#19
Ho Yen Fong, Sri Nurestri Abd Malek, Hui Shin Yee, Saiful Anuar Karsani
Background: Cervical cancer has become one of the most common cancers in women and currently available treatment options for cervical cancer are very limited. Naturally occurring chalcones and its derivatives have been studied extensively as a potential anticancer agent in different types of cancer and helichrysetin is naturally occurring chalcone that possess potent antiproliferative activity toward human cancer cells. Materials and Methods: Inhibitory activity of helichrysetin was evaluated at different concentrations...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29199518/improvement-on-upper-limb-body-powered-prostheses-1921-2016-a-systematic-review
#20
Nur Afiqah Hashim, Nasrul Anuar Abd Razak, Noor Azuan Abu Osman, Hossein Gholizadeh
Body-powered prostheses are known for their advantages of cost, reliability, training period, maintenance, and proprioceptive feedback. This study primarily aims to analyze the work related to the improvement of upper limb body-powered prostheses prior to 2016. A systematic review conducted via the search of the Web of Science electronic database, Google Scholar, and Google Patents identified 155 papers from 1921 to 2016. Sackett's initial rules of evidence were used to determine the levels of evidence, and only papers categorized in the design and development category and patents were analyzed...
December 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
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