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Lin Yin, Fang Liu, Changcheng Guo, Qiong Wang, Ke Pan, Liangbi Xu, Yan Xiong, Yingting Chen, Zhenghong Chen
The present study aimed to investigate the virulence diversity of Helicobacter pylori (H. pylori) in major ethnic groups residing in Guizhou province, China, and its association with clinical outcomes. Gastric mucosal biopsies were collected from the pylorus of patients with gastrointestinal disorders. H. pylori was identified by colonial morphology, Gram staining, a urease test and H. pylori‑specific 16S rRNA gene fragment PCR amplification. DNA was extracted from pure culture and used for virulence gene analysis...
September 5, 2018: Molecular Medicine Reports
Mervat M Swelam, Rasha A H El-Barbary, Wael M Saudi, Marwa S Fathi, Dina A Soliman, Heba H Abd Elrehem
BACKGROUND: Acne vulgaris (AV) pathogenesis is multifactorial. Vitamin D (VitD) plays an important role in sebocytes' differentiation and function. Most VitD functions are mediated by the nuclear VitD receptor (VDR) following binding of its biologically active form (1,25 dihydroxyvitamin D3). Genetic variations in VDR gene may cause significant receptor dysfunction and have been found to be associated with many inflammatory skin diseases. Two adjacent single nucleotide polymorphisms of VDR, ApaI (rs7975232) and TaqI (rs731236), were commonly studied...
September 15, 2018: Journal of Cosmetic Dermatology
Bussarakam Chuppava, Birgit Keller, Amr Abd El-Wahab, Jessica Meißner, Manfred Kietzmann, Christian Visscher
Gaining knowledge about the spread of resistance against antibacterial agents is a primary challenge in livestock farming. The purpose of this study was to test the effect of double antibiotic treatment (at days 10⁻14 and days 26⁻30) with enrofloxacin or solely environmental exposition (identical times, directly into the litter) on resistance against antibacterial agents in commensal Escherichia coli in comparison with the control (without treatment), depending on different flooring. A total of 720 Big 6 turkeys participated in three trials...
September 13, 2018: International Journal of Environmental Research and Public Health
Hui Li Heng, Chin Fei Chee, Chun Keng Thy, Jia Ti Tee, Sek Peng Chin, Deron R Herr, Michael J C Buckle, Ian C Paterson, Stephen W Doughty, Noorsaadah Abd Rahman, Lip Yong Chung
Compounds with activity at serotonin (5-hydroxytryptamine) 5-HT2 and α1 adrenergic receptors have potential for the treatment of central nervous system (CNS) disorders, drug addiction or overdose. Isolaureline, dicentrine and glaucine enantiomers were synthesised and their in vitro functional activities at human 5-HT2 and adrenergic α1 receptor subtypes were evaluated. The enantiomers of isolaureline and dicentrine acted as antagonists at 5-HT2 and α1 receptors with (R)-isolaureline showing the greatest potency (pKb = 8...
September 14, 2018: Chemical Biology & Drug Design
Linda S Aglio, Muhammad M Abd-El-Barr, Vwaire Orhurhu, Grace Y Kim, Jie Zhou, Laverne D Gugino, Lisa J Crossley, James L Gosnell, John H Chi, Michael W Groff
OBJECTIVE Preemptive administration of analgesic medication is more effective than medication given after the onset of the painful stimulus. The efficacy of preoperative or preemptive pain relief after thoracolumbosacral spine surgery has not been well studied. The present study was a double-blind, placebo-controlled randomized trial of preemptive analgesia with a single-shot epidural injection in adult patients undergoing spine surgery. METHODS Ninety-nine adult patients undergoing thoracolumbosacral operations via a posterior approach were randomized to receive a single shot of either epidural placebo (group 1), hydromorphone alone (group 2), or bupivacaine with hydromorphone (group 3) before surgery at the preoperative holding area...
September 14, 2018: Journal of Neurosurgery. Spine
Mohammed Hassan Jabal, Abdulmunem R Abdulmunem, Hussain Saad Abd
Plant oil (vegetable) has been evaluated to substitute the mineral-based lubricants due to its natural and friendly characteristics for environment. Availability of vegetable oil made it a renewable source of bio- oils. Additionally, vegetable oil based lubricants has indicated a potentials for reducing hydrocarbon emission and carbon dioxide while utilizing in the IC engines and industrial operations. In this study, the sunflower oil was investigated to study its lubricant characteristics under different loads using the four-ball tribometer and tested the exhaust emissions using a four stroke single cylinder diesel engine...
September 14, 2018: Journal of the Air & Waste Management Association
Parviz Padisar, Roya Hashemi, Mohammadreza Naseh, Bahareh Abde Nikfarjam, Mahdi Mohammadi
Background: Orthodontic tooth movement (OTM) is based on induction of periodontal tissue remodeling. Mechanical tooth stimulation results in the release of pro-inflammatory mediators. These mediators cause bone resorption and deposition at the pressure and tension sites and play a role in OTM. Thus, assessment of chemical biomarkers can help determine the exact amount of load and its duration of application required for each tooth and select the most efficient treatment plan with minimal complications...
August 2018: Electronic Physician
Ahmed Khaled Tawfik, Amal Helmy, Mohamed Yousef, Sabry Abou-Saif, Abdelrahman Kobtan, Eman Asaad, Sherief Abd-Elsalam
Objectives: The aim of the work was to assess the level of copeptin as a surrogate marker predicting the severity of liver diseases and its major complications. Patients and methods: This was a cross-sectional study that included 40 patients and 10 controls and was performed in Tanta University Hospital between June 2016 and November 2016. The studied cases were divided into five groups: group I (10 patients): compensated cirrhosis; group II (10 patients): cirrhosis with gastrointestinal hemorrhage due to portal hypertension; group III (10 patients): cirrhosis with hepatorenal syndrome; group IV (10 patients): cirrhosis with liver cell failure; and group V (10 controls): normal healthy individuals...
2018: Hepatic Medicine: Evidence and Research
Tae Woo Jung, Sung Hoon Lee, Hyoung-Chun Kim, Joon Seok Bang, A M Abd El-Aty, Ahmet Hacımüftüoğlu, Yong Kyoo Shin, Ji Hoon Jeong
Physical activity has many beneficial effects on metabolic disorders, such as obesity, insulin resistance, and diabetes. Meteorin-like protein (METRNL), a novel secreted protein homologous to the neurotrophin Metrn, is induced after exercise in the skeletal muscle. Herein, we investigated the effects of METRNL on lipid-mediated inflammation and insulin resistance in skeletal muscle via AMP-activated protein kinase (AMPK) or peroxisome proliferator-activated receptor δ (PPARδ). Treatment with METRNL suppressed inflammatory markers, such as nuclear factor κB (NFκB) nuclear translocation, inhibitory κBα (IκBα) phosphorylation, interleukin-6 (IL-6) expression, and pro-inflammatory cytokines (such as TNFα and MCP-1)...
September 13, 2018: Experimental & Molecular Medicine
Magdy Gouda, Wail Fayez Nasr, Mohammad El-Sayed Abd Elbary, Magdy M A Razek
The main goal of surgery of cholesteatoma is eradication of the disease and revision surgery is indicated when a dry and safe ear has not been achieved. Residual cholesteatoma usually occurs at the sites that are difficult to reach with an operating microscope, such as posterior tympanum and anterior epitympanic recess. Computed tomography can be performed to delineate the extent of disease. High-resolution computed tomography scanning is important for planning for surgery and is indicated for all revision mastoid operations...
September 2018: Indian Journal of Otolaryngology and Head and Neck Surgery
Maimiza Zahari, Siti Aishah Sulaiman, Zulhabri Othman, Yasmin Ayob, Faraizah Abd Karim, Rahman Jamal
Background: Haemophilia A (HA) and Haemophilia B (HB) are X-linked blood disorders that are caused by various mutations in the factor VIII (F8) and factor IX (F9) genes respectively. Identification of mutations is essential as some of the mutations are associated with the development of inhibitors. This study is the first comprehensive study of the F8 mutational profile in Malaysia. Materials and methods: We analysed 100 unrelated HA and 15 unrelated HB patients for genetic alterations in the F8 and F9 genes by using the long-range PCR, DNA sequencing, and the multiplex-ligation-dependent probe amplification assays...
2018: Mediterranean Journal of Hematology and Infectious Diseases
Hesham Fouad Aly, Ahmed Ibrahim Abd-Elhamid
  The present research deals with the development a fast and low-cost method for removing color dye from water using nanosized semiconductors SiO2 as photocatalyst. The studies of kinetic photocatalytic degradation were carried out on an aqueous solution of soluble methylene blue dye, which contained SiO2 nanoparticles and under an ultraviolet light source. Different parameters affecting the process have been studied: catalyst concentration, dye concentration, temperature, and pH of solution. The color variation was detected at three absorption bands (662, 293, and 243 nm)...
September 1, 2018: Water Environment Research: a Research Publication of the Water Environment Federation
Jade B Mitchell, Laura Y Sifuentes, Austin Wissler, Sherif Abd-Elmaksoud, Gerardo U Lopez, Charles P Gerba
AIMS: Quantitative data on the doses needed to inactivate microorganisms on fomites is not available for ultraviolet applications. The goal of this study was to determine the doses of UV light needed to reduce bacteria and murine norovirus on hard surface fomites through experimentation and to identify appropriate models for predicting targeted levels of reduction. METHODS AND RESULTS: Stainless steel and Formica laminate coupons were selected as they are common surfaces found in healthcare settings...
September 10, 2018: Journal of Applied Microbiology
Hatem Hussein Al-Ahmady, Ahmad Farouk Abd Elazeem, Nermeen El-Moataz Bellah Ahmed, Wael Mahmoud Shawkat, Mohamed Elmasry, Mostafa Ahmed Abdelrahman, Mohsena Ahmed Abderazik
INTRODUCTION: The aim of this study was to examine and assess the use of autologous bone marrow mononuclear cells (BMMNCs) combined with platelet-rich fibrin (PRF) and nanohydroxyapatite for bone regeneration as an effective technique for alveolar cleft repair. PATIENTS AND METHODS: This study included 20 patients with unilateral alveolar cleft defects and with an age range of 8-15 years. They were divided equally into two groups: Group A, received treatment via the regenerative approach which includes; autologous BMMNCs seeded on a collagen sponge in combination with nanohydroxyapatite and autologous PRF...
September 2018: Journal of Cranio-maxillo-facial Surgery
Mahmoud Fathy Tahoun, Marc Tey, Jesús Mas, Taher Abd-Elsattar Eid, Joan Carles Monllau
PURPOSE: To evaluate the functional outcome of using chitosan-based material in our patients after 2 years of follow-up. METHODS: Nonarthritic nondysplastic femoroacetabular impingement patients with an acetabular chondral lesion, 18 to 55 years of age, were included for arthroscopic repair between May 2013 and July 2015. Full-thickness chondral defects ≥2 cm2 were filled with chitosan-based implant after microfractures. Follow-up consisted of alpha angle assessment and clinical outcome in the form of the Non Arthritic Hip Score (NAHS), International Hip Outcome Tool 33 (iHOT33), Hip Outcome Score of Activities of Daily Living (HOS-ADL), and Hip Outcome Score of Sports Specific Scale (HOS-SSS)...
September 5, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Mohamed S Sweed, Ahmed K Makled, Medhat A El-Sayed, Mohamed E Shawky, Hamdy A Abd-Elhady, Ahmed M Mansour, Radwa M Mohamed, Hossam Hemeda, Eman A Nasr-Eldin, Neveen S Attia, Ebtihal Eltaieb, Heba Allam, Ahmed Hussein
STUDY OBJECTIVE: Because laparoscopic ovarian cystectomy of endometriomas is known to adversely impact patient ovarian reserve, the search for other techniques of surgical management is ongoing, and the objective of the current study was to evaluate laparoscopic cyst deroofing as a feasible alternative. STUDY DESIGN: Prospective, randomized clinical trial (Canadian Task Force classification I). SETTING: A university maternity hospital. PATIENTS: Women diagnosed with unilateral or bilateral ovarian endometriomas...
September 4, 2018: Journal of Minimally Invasive Gynecology
Mahmoud M Abd Elwakil, Moustafa T Mabrouk, Maged W Helmy, Elsayeda-Zeinab A Abdelfattah, Sachin K Khiste, Kadria A Elkhodairy, Ahmed O Elzoghby
AIM: The use of inhalable nanomedicines can overcome the Enhanced permeation and retention effect (EPR)-associated drawbacks in lung cancer therapy via systemic nanomedicines. METHODS: We developed a lactoferrin-chondroitin sulfate nanocomplex for the co-delivery of doxorubicin and ellagic acid nanocrystals to lung cancer cells. Then, the nanocomplex was converted into inhalable nanocomposites via spray drying. RESULTS: The resulting 192.3 nm nanocomplex exhibited a sequential faster release of ellagic acid, followed by doxorubicin...
September 7, 2018: Nanomedicine
Sameh S Raafat, Ali A Ramzy, Amr F El-Hadidy, Mohamed A Abd Allah, Hany F Hanna
Aim: To evaluate the reliability of the mitral leaflet separation (MLS) index against the traditional echocardiographic methods in measuring mitral valve area (MVA) pre and post percutaneous balloon mitral valvuloplasty (PBMV). Methods: Ninety patients suffering symptomatic moderate to severe MS underwent PBMV at Ain Shams University Hospital in cardiology department. Seventy of the patients were females representing 77.8% and 20 were males representing 22.2%. Their age ranged from 22 to 56 years...
September 2018: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
Manal Abd El Baky Mahmoud, Menat Allah Ali Shaaban, Ali Ali Ramzy
Objective: To assess the role of Copeptin in diagnosis of acute myocardial infarction in troponin-blind period. Subjects and methods: This study was conducted on 40 patients who presented to emergency department complaining of chest pain and were highly suspicious to have acute cardiac ischemia, in addition to 10 subjects serving as a healthy control group. Blood samples were collected for determination of CK-MB, cTnI and Copeptin. These were measured twice (in patients' group); at 3 h and then at 6-9 h from admission time...
September 2018: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
Ashraf M A Barakat, Sylvia O Ahmed, Mona S Zaki, Hassan A El Fadaly, Khaled A Abd El-Razik, Hazem M El-Hariri, Dina Johar
BACKGROUND: Toxoplasma gondii is an acute or latent zoonotic abortifacient human protozoan. Women may be aborted due to recent or latent infection during pregnancy or order to flare up of the dormant bradyzoites to acute tachyzoites (latent opportunistic relapse). AIMS: 1) to validate the interpretation of IgM and IgG immunoglobulins seromonotoring with DNA comparative results in differentiating recent from latent T. gondii abortion. METHOD: Blood with the corresponding placental or uterine wash samples were collected from 73 aborted Egyptian women from Cairo and Giza labour wards...
September 3, 2018: Microbial Pathogenesis
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