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Max A A Vogel, Johan W E Jocken, Henrike Sell, Nicole Hoebers, Yvonne Essers, Kasper M A Rouschop, Merima Cajlakovic, Ellen E Blaak, Gijs H Goossens
Context and Objectives: Upper and lower-body adipose tissue (AT) exhibit opposing associations with obesity-related cardiometabolic diseases. Recent studies have suggested that altered AT oxygen tension (pO2) may contribute to AT dysfunction. Here, we compared in vivo abdominal (ABD) and femoral (FEM) subcutaneous AT pO2 in overweight and obese women, and investigated the effects of physiological AT pO2 on human adipocyte function. Design: ABD and FEM subcutaneous AT pO2 and AT blood flow (ATBF) were assessed in 8 overweight and obese (BMI 34...
July 17, 2018: Journal of Clinical Endocrinology and Metabolism
Hala Kfoury, Mohammed Mubarak, Abd Assalam Qannus, Malak Alshareef, Jwaher Alharbi, Hadeel Alghurair, Alanoud Bin Omair, Najd Alshamlan, Lama Raddaoui, Hisham Alkhalidi
AIM: To identify the underlying diseases with TRI-positive kidney biopsies, and describe the histological pattern and spectrum of TRI-positive kidney biopsies. METHODS: A retrospective analysis of all patients' chart that underwent renal biopsy at King Saud University Medical City between 2012 and 2017 was done. Kidney biopsies that indicated a positive result for tubuloreticular inclusions (TRI's) on electron microscopy were reviewed and the underlying disease and histological pattern was extracted...
July 18, 2018: Ultrastructural Pathology
Yasmina M Abd-Elhakim, Abeer Anwar, Mohamed M Hashem, Gihan G Moustafa, Khaled Abo-El-Sooud
The present study examined the impacts of sodium acetate (SA), sodium acid pyrophosphate (SAPP), and citric acid (CA) on the viability, proliferation, and DNA damage of isolated lymphocytes in vitro. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) release assays were adopted to evaluate cell viability, while comet assay was employed to assess the genotoxic effects. The cells were incubated with different levels of SA (50, 100, and 200 mM), SAPP (25, 50, and 100 mM/L), or CA (100, 200, and 300 μg/mL)...
July 18, 2018: Journal of Biochemical and Molecular Toxicology
Omar Ayman Saadeldin, Mohamed Ahmed Abd El Salam, Omar Abdulsalam Azzazi, Abdullah Yousef Mohamed
Congenital anomalies of the male urogenital tract include a variety of structural abnormalities. These abnormalities could affect either the male external genitalia, internal genitalia or both. Congenital anomalies of the vas deferens are rare and may include unilateral or bilateral (agenesis, atresia, duplication, ectopy or diverticulum) that could be complete or segmental. In addition, they may be isolated anomalies of the vas deferens or may be associated with other congenital anomalies elsewhere especially in the male urogenital tract...
July 17, 2018: Andrologia
Suhana Shaharom, Mohd Talib Latif, Md Firoz Khan, Siti Norbalqis Mohd Yusof, Nor Azura Sulong, Nurul Bahiyah Abd Wahid, Royston Uning, Suhaimi Suratman
This study aims to determine the concentrations of surfactants in the surface microlayer (SML), subsurface water (SSW) and fine mode aerosol (diameter size < 1.5 μm) at different coastal stations in Peninsular Malaysia. The concentrations of anionic and cationic surfactants were determined through colorimetric methods as methylene blue active substances (MBAS) and disulphine blue active substances (DBAS), respectively. Water-soluble ions, for the determination of fine mode aerosol sources, were determined using ion chromatography (IC) for anions (SO4 2- , NO3 - , Cl- and F- ) and cations (Na+ , K+ , Ca2+ and Mg2+ )...
July 17, 2018: Environmental Science and Pollution Research International
Anna Haberberger, Benedikt Kirchner, Irmgard Riedmaier, Reinhard Henschler, Christian Wichmann, Raymund Buhmann, Michael W Pfaffl
Objectives: For several decades, autologous blood doping (ABD) in sports has been a major problem, and even today there is still no reliable method for satisfactorily detecting ABD. For this kind of doping, stored individual erythrocytes are used to increase stamina and endurance caused by a higher erythrocyte level in the athlete's body. Since there is growing evidence that these cells are enriched with microRNAs (miRNAs), this study has been carried out to discover and validate all miRNAs occurring in fresh blood as well as in stored blood...
2018: BMJ Open Sport & Exercise Medicine
Marwa M Nagib, Mariane G Tadros, Hadwa Ali Abd Al-Khalek, Rania M Rahmo, Nagwa Ali Sabri, Amani E Khalifa, Somaia I Masoud
Current anticonvulsant therapies are principally aimed at suppressing neuronal hyperexcitability to prevent or control the incidence of seizures. However, the role of oxidative stress processes in seizures led to the proposition that antioxidant compounds may be considered as promising candidates for limiting the progression of epilepsy. Accordingly, the aim of this study is to determine if coenzyme Q10 (CoQ10) and alpha-tocopherol (α-Toc) have a neuroprotective effect in rats against the observed oxidative stress and inflammation during seizures induced by pentylenetetrazole (PTZ) in rats, and to study their interactions with the conventional antiseizure drug phenytoin (PHT), either alone or in combination...
July 11, 2018: Neurotoxicology
Mervat A Ahmed, Mona A Mohamed, Laila A Rashed, Sohaier A Abd Elbast, Elham A Ahmed
The present study investigated the molecular effects of rice bran oil (RBO) on lipid-regulatory genes (sterol regulatory element binding protein-1 [Srebf1] and peroxisome proliferator-activated receptors-α [Ppara]) and the expression of catalase (CAT) and superoxide dismutase (SOD1) genes in insulin-resistant rats. Rats were divided into five groups: animals that received standard diet (control); rats fed standard diet containing RBO as the sole source of fat (RBO); a high-fructose diet (HFD) group, which was further divided into two subgroups: rats fed HFD either for only 1 month (HFD1) or for 2 months (HFD2) and rats fed HFD containing RBO for 1 month; while rats in the last group fed HFD for 30 days then treated with RBO for another 30 days...
July 17, 2018: Lipids
Zainab Sabry Othman Ahmed, Xin Li, Feng Li, Hassan Ali Cheaito, Kush Patel, El-Sayed Mohammed Mosallam, Gehad Abd El-Fattah Hassan Elbargeesy, Q Ping Dou
Isothiocyanates (ITCs) are natural chemoprotective products found abundantly in cruciferous vegetables. However, the cancer-relevant targets and molecular mechanisms of ITCs remain unclear. We hypothesize that ITCs, as electrophiles, can interact with the catalytic triads (CYS, HIS, and ASP) of the proteasomal cysteine deubiquitinases USP14 and UCHL5, ultimately inhibiting their activities. In the current study, we exploited this possibility by performing both computational docking and biochemical validation assays using human breast and prostate cancer cell models...
July 17, 2018: Journal of Cellular Biochemistry
Asmaa Abd El Gwad, Marwa Matboli, Ahmed El-Tawdi, Eman K Habib, Hanan Shehata, Doaa Ibrahim, Fathy Tash
Recent research has tried to use exosomal RNAs (coding and noncoding) as potential diagnostic markers for hepatocellular carcinoma (HCC). Initially, by using bioinformatics, we selected an HCC-exosomal RNA-based biomarker panel. The choice of this panel depends on the integration of Ras-related in brain (RAB11A) gene expression and its competing endogenous network. This network includes long noncoding RNA RP11-513I15.6 (lncRNA-RP11-513I15.6) and microRNA-1262 (miR-1262). Secondly, we tried to validate the expression of this network in the sera of 60 patients with HCC in comparison with 42 chronic hepatitis C virus-infected patients and 18 healthy controls...
July 17, 2018: Journal of Cellular Biochemistry
Sören Hansen, Oumar Faye, Sabri S Sanabani, Martin Faye, Susanne Böhlken-Fascher, Ousmane Faye, Amadou A Sall, Michaël Bekaert, Manfred Weidmann, Claus-Peter Czerny, Ahmed Abd El Wahed
BACKGROUND: Outbreaks of fever of unknown origin start with nonspecific symptoms and case definition is only slowly developed and adapted, therefore, identifying the causative agent is crucial to ensure suitable treatment and control measures. As an alternative method for Polymerase Chain Reaction in molecular diagnostics diagnostic, metagenomics can be applied to identify the pathogen responsible for the outbreak through sequencing all nucleic acids present in a sample extract. Sequencing data obtained can identify new or variants of known agents...
July 6, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Khaled Abo-El-Sooud, Mohamed M Hashem, Yasmina M Abd ElHakim, Gehan M Kamel, Ali Q Gab-Allaha
The present study was planned to examine the effect of butylated hydroxy toluene (BHT) on the immune response of Rift Valley fever vaccine (RVFV) in Swiss mice. Animals were divided into four equal groups. The first group was kept as negative control. The 2nd group was orally administrated with the acceptable daily intake (ADI) of BHT 0.3 mg/kg b.wt. daily for 21 days and the 3rd group were vaccinated only by inactivated RVFV at a dose of 0.2 ml I/P two times. The 4th group was orally administrated BHT as in the 2nd group and vaccinated by inactivated RVFV as in the 4th group...
July 12, 2018: International Immunopharmacology
Francesca Tucci, Valeria Calbi, Federica Barzaghi, Maddalena Migliavacca, Francesca Ferrua, Maria Ester Bernardo, Daniele Canarutto, Giulia Consiglieri, Salvatore Recupero, Francesco Calzatini, Michela Gabaldo, Caterina Lucano, Miriam Casiraghi, Silvia Darin, Francesca Dionisio, Sarah Marktel, Enza Cestone, Renato Finazzi, Giorgina Mieli-Vergani, Enzo Boeri, Jonathan Appleby, Dalia Abd Elaziz, Fabio Ciceri, Alessandro Aiuti, Maria Pia Cicalese
Patients with inborn error diseases can be candidates for autologous haematopoietic stem cells (HSC) gene therapies (GT) but may require negative viral screening, including Hepatitis C (HCV), to allow HSC manipulation in Good Manufacturing Practices areas. In case of HCV positivity, patients might be excluded from life-saving treatments. As HCV antibodies could be negative in young infant immunodeficient patients due to their immature/impaired immune system, or positive due to maternal-fetal antibody transmission, the risk is usually also evaluated on the basis of the HCV-RNA...
July 16, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Omar Hussein, Khalid Sawalha, Mohammad Hamed, Ahmed Abd ElAzim, Lai Wei, Michel T Torbey, Archana Hinduja
BACKGROUND: The presence of the spot sign on computed tomography angiogram (CTA) is considered a sign of active bleeding, and studies have shown it can predict hematoma expansion in intraparenchymal hemorrhage (IPH). The spot sign in intraventricular hemorrhage (IVH) has not been explored yet. The purpose of this study is to estimate the prevalence of the intraventricular-spot sign, and its prediction of hematoma expansion and clinical outcomes. METHODS: We retrieved data of hemorrhagic stroke patients seen at our medical center from January 2013 to January 2018...
July 16, 2018: Journal of Neurology
Jehan Ahmed Sayed, Sayed Kaoud Abd Elshafy, Emad Zareif Kamel, Mohamed Amir Fathy Riad, Amal Ahmed Mahmoud, Ghada Shalaby Khalaf
Background: Immune responses appear to be affected by anesthetics and analgesics. We investigated the effects of caudal tramadol on the postoperative immune response and pain management in pediatric patients. Methods: Sixty ASA-I pediatric patients aged 3-10 years undergoing lower abdominal surgery. Patients were randomly assigned either to a caudal bupivacaine (0.25%) group (group B), or a group that received caudal tramadol (1 mg/kg) added to the bupivacaine (0...
July 2018: Korean Journal of Pain
Th I Shaheen, Abeer A Abd El Aty
In the realm of green synthesis of metals nanoparticles for medical textile application, silver nanoparticles (AgNPs) were biosynthesized in situ cotton fabrics for the first time by using fungi for rendering cotton fabrics antimicrobial activity with abroad range towards different pathogenic organisms. Herein, five different isolated fungi from medicinal plants were identified and optimized their growth media prior examined their ability to reduce Ag+ ions to AgNPs in-situ cotton fabrics along with ex-situ method...
July 13, 2018: International Journal of Biological Macromolecules
Islam Ibrahim Hegab, Rania Nagi Abd-Ellatif, Mona Tayssir Sadek
The protective effect of N- acetylcysteine (NAC) and genistein (GEN) on an experimental model of indomethacin (IND) - induced gastric injury was investigated. 50 male rats were divided into 5 groups: control (I), IND (II), NAC pretreated (III), GEN Pretreated (IV), NAC+GEN pretreated (V). Rats were orally administered NAC (500 mg/kg), GEN (10 mg/kg) or both once daily for 7 days before the induction of the gastric injury by IND (50 mg/kg). Stomach was removed for biochemical analysis and histopathological examinations...
July 16, 2018: Canadian Journal of Physiology and Pharmacology
Ahmad M Farag, Hesham H Sokker, Ehab M Zayed, Faten A Nour Eldien, Naglaa M Abd Alrahman
The removal of industrial pollutants from wastewater is important to protect human health and the environment. For this reason, bifunctional hydrogel was synthesized by radiation-induced grafting copolymerization of 2-acrylamido-2-methylpropane-1-sulphonic acid (AMPS) and dimethylaminoethyl methacrylate (DMAEMA) onto starch and subsequent chemical modification of the prepared hydrogel by benzyl chloride. The physical and chemical properties of the hydrogel AMPS co DMAEMA modified with ion-exchange groups were investigated by FT-IR, DSC and SEM techniques...
July 12, 2018: International Journal of Biological Macromolecules
Ghada Abdelmoemen, Samy Abdelkader Khodeir, Ahmed Nabil Zaki, Maha Kassab, Sabry Abou-Saif, Sherief Abd-Elsalam
BACKGROUND & AIMS: Insulin resistance is the real determinant of both Nonalcoholic fatty liver disease (NAFLD) and diabetes, and can facilitate the accumulation of triglycerides in the liver. Overexpression of hepassocin (HPS) increased the accumulation of hepatic fat and NAFLD activity scores (NAS) in mice. The aim of this study was to investigate the relationship between hepassocin and steatosis of the liver in diabetic patients with or without NAFLD in humans. METHODS: The study enrolled 60 patients plus 20 healthy controls that were divided into 4 groups: Group I: included 20 patients who were diagnosed as diabetes mellitus type 2, Group II: included 20 patients who were diagnosed as nonalcoholic fatty liver disease (NAFLD), Group III: included 20 patients who were diagnosed as diabetes type 2 and NAFLD, and Group IV (control group): included 20 healthy person or controls who were matched in age and sex with patients group...
July 15, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Zahra Khazaeipour, Abolfazl Abouie, Fatemeh Zarei, Hamid Mirzaaghaie, Afsaneh Abd-Mousavi, Alireza Salehi-Nejad, Alexander R Vaccaro, Vafa Rahimi-Movaghar
OBJECTIVE: To explore individuals` perception of the personal, family and societal educational needs following a spinal cord injury (SCI). METHODS: Sixty-one patients who sustained a traumatic SCI between March 2015 and June 2016 referred to Brain and Spinal Cord Injury Research Center (BASIR) were included in a cross sectional study and completed an online survey containing open-and closed-ended questions, in Iran. Participants` responses were analyzed using a qualitative approach with a thematic analysis...
July 2018: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
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