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Gati K Panigrahi, Prakash P Praharaj, Taylor C Peak, Jessica Long, Ravi Singh, Johng S Rhim, Zakaria Y Abd Elmageed, Gagan Deep
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April 24, 2018: Scientific Reports
Abdulrahman M Alahdal, Hani Z Asfour, Safwat A Ahmed, Ahmad O Noor, Ahmed M Al-Abd, Mahmoud A Elfaky, Sameh S Elhady
The Red Sea specimen of the marine sponge Hyrtios erectus (order Dictyoceratida) was found to contain scalarane-type sesterterpenes. 12- O -deacetyl-12,19-di- epi -scalarin ( 14 ), a new scalarane sesterterpenoid, along with fourteen previously-reported scalarane-type sesterterpenes ( 1 ⁻ 13 and 15 ) have been isolated. The chemical structures of the isolated compounds were elucidated on the basis of detailed 1D and 2D NMR spectral data and mass spectroscopy, as well as by comparison with reported data. The anti- Helicobacter pylori , antitubercular and cytotoxic activities of all fifteen compounds were evaluated to reveal the potency of Compounds 1 , 2 , 3 , 4 , 6 , 7 and 10 ...
April 23, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Daniel Winkler, Eduardo Mateos
Two species of Lepidocyrtus Bourlet have been studied. L. peisonis Traser Christian, 1992 has been redescribed based on the type material and newly collected specimens. This species is characterized by dorsal macrochaetae formula R0R1sR1R2So/00/0101+3, truncate unguiculi and a newly observed character missing in the original description: a lateral tuft of long filiform chaetae on abd. III, never described for any European species of subgenera Lanocyrtus and Lepidocyrtus s.str. L. mariani Traser Dányi, 2008 has been revised based on the holotype and recently collected specimens...
January 25, 2018: Zootaxa
Ling Dong, Yue-Li Yang, Yu-Yao Zhao, Yuan-Jun Wang, Ji-Gang Jiang
Genus Rambutanura Deharveng, 1988 of subfamily Neanurinae is herein recorded and a new species is described from China. A key to the species of the whole world of the genus is provided. In order to determine the new species, a new diagnosis within the genus Rambutanura Deharveng, 1988 is proposed. The new species is distinguished from all known members of the genus by its unique set of morphological characters notably: 2+2 depigmented eyes, mandible quadridentate, presence of 1 additional s-chaeta on each tubercle Di from Th...
February 8, 2018: Zootaxa
Mirette M Aziz, Hosnia S Abd El-Megeed, Mennat Allah M Abd Ellatif
OBJECTIVES: to assess the health seeking practices and their determinants among Umrah pilgrims departing from Assiut international Airport. METHODS: We interviewed 300 pilgrims departing from Assiut International Airport while they were in the departure lounge, using a semi-structured questionnaire. RESULTS: Only 60%, 46.3% and 46.3% of Umrah pilgrims believed in importance of pre-travel vaccination, seeking health information, and health examination, respectively...
April 21, 2018: Travel Medicine and Infectious Disease
Sara Nageeb El-Helaly, Basant A Habib, Mohamed K Abd El-Rahman
This study aims to investigate factors affecting weakly basic drugs liposomal systems. Resolution V fractional factorial design (2V 5-1 ) is used as an example of screening designs that would better be used as a wise step before proceeding with detailed factors effects or optimization studies. Five factors probable to affect liposomal systems of weakly basic drugs were investigated using Amisulpride as a model drug. Factors studied were; A: Preparation technique B: Phosphatidyl choline (PhC) amount (mg) C: Cholesterol: PhC molar ratio, D: Hydration volume (ml) and E: Sonication type...
April 21, 2018: European Journal of Pharmaceutical Sciences
Azza Ali Abd El-Azeem Taha, Hany Ahmed Abu-Zaid, Dalia El-Sayed Desouky
BACKGROUND: Eating disorders are a common health problem among adolescents, and females are especially vulnerable to them. There is lack of information on the prevalence of eating disorders in Saudi Arabia. The current study aimed to investigate the prevalence of eating disorders among female undergraduate university students in Taif city, Saudi Arabia. METHODS: The study was undertaken in the female section at Taif university from November 1, 2016 to March 30, 2017...
March 1, 2018: Archives of Iranian Medicine
Imtiaz Hussain Raja Abbasi, Farzana Abbasi, Lamei Wang, Mohamed E Abd El Hack, Ayman A Swelum, Ren Hao, Junhu Yao, Yangchun Cao
Folate has gained significant attention due to its vital role in biological methylation and epigenetic machinery. Folate, or vitamin (B9 ), is only produced through a de novo mechanism by plants and micro-organisms in the rumen of mature animals. Although limited research has been conducted on folate in ruminants, it has been noted that ruminal synthesis could not maintain folate levels in high yielding dairy animals. Folate has an essential role in one-carbon metabolism and is a strong antiproliferative agent...
April 23, 2018: AMB Express
Salam A Mohammed, Lamya Al Amouri, Emad Yousif, Ali Abd Ali, Fazal Mabood, Hazim F Abbas, Sausan Alyaqoobi
Vanadium oxide has been largely exploited as a catalyst in many industrial applications. In this article, we show the synthesis of vanadium oxide (V2 O5 ): Nickel Oxide (NiO) composite using sol-gel method at optimum conditions. The composite nanomaterials were used to remove methyl orange from waste water via harnessing the photocatalytic activity of it which showed an excellent efficiency of removal at 88%, and 93% after the exposure to the light, and light with heating respectively. This will pave the way into further implementation of these nanomaterials in the removal of some other dyes and contaminants from wastewater...
March 2018: Heliyon
Emad Zarief Kamel, Sayed Kaoud Abd-Elshafy, Jehan Ahmed Sayed, Mohammed Mahmoud Mostafa, Mohamed Ismail Seddik
Background: Magnesium is one of the effective, safe local anesthetic adjuvants that can exert an analgesic effect in conditions presenting acute and chronic post-sternotomy pain. We studied the efficacy of continuous infusion of presternal magnesium sulfate with bupivacaine for pain relief following cardiac surgery. Methods: Ninety adult patients undergoing valve replacement cardiac surgery randomly allocated into three groups. In all patients; a presternal catheter was placed for continuous infusion of either 0...
April 2018: Korean Journal of Pain
Güler Demirbas-Uzel, Henry M Kariithi, Andrew G Parker, Marc J B Vreysen, Robert L Mach, Adly M M Abd-Alla
Salivary gland hytrosaviruses (SGHVs, family Hytrosaviridae ) are non-occluded dsDNA viruses that are pathogenic to some dipterans. SGHVs primarily replicate in salivary glands (SG), thereby inducing overt salivary gland hypertrophy (SGH) symptoms in their adult hosts. SGHV infection of non-SG tissues results in distinct pathobiologies, including reproductive dysfunctions in tsetse fly, Glossina pallidipes (Diptera: Glossinidae) and house fly. Infection with the G. pallidipes virus (GpSGHV) resulted in the collapse of several laboratory colonies, which hindered the implementation of area wide integrated pest management (AW-IPM) programs that had a sterile insect technique (SIT) component...
2018: Frontiers in Microbiology
Sherif Mohamed Abdelgaid, Ahmed Fawaz Moursy, Eyad Abd Allah Elgebaly, Aly Mohamed Aboelenien
The complex nature of ankle fractures is magnified when seen in patients at high risk of soft tissue wound healing complications. The major categories include associated soft tissue injury, diabetes, tobacco use, peripheral vascular disease, malnutrition, alcoholism, and corticosteroid use. Because of the potential for wound dehiscence and infection with open reduction and internal fixation of ankle fractures in these patients, minimally invasive procedures have been described. The aims of the present study were to assess the possibility for, and evaluate the results and complications of, minimally invasive techniques for different types of malleolar fractures in high-risk patients...
May 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
Sherien Salah Ghaleb, Dalia Abd Elwahab Hassan, Alla Mohamed Shehab, Soad Abd El-Ghafar Mohamed Hassan
Disability is a complex problem that results in detrimental effects on the victim. The number of disabled has increased considerably. The development constitutes a good reason for paying more specific attention to society's growing number of disabled. The physician's duties are not only to describe the anatomic and physiological defects present in the injured individual, but also to answer questions regarding the patient ability to perform specific economic or social function. This study aimed to clear up some of the problems or difficulties that may face the medico-legal physician or any personal that may be concerned with the process of evaluation...
April 14, 2018: Journal of Forensic and Legal Medicine
Waleed H Malki, Ahmed M Gouda, Hamdy E A Ali, Rabaa Al-Rousan, Doaa Samaha, Ashraf N Abdalla, Juan Bustamante, Zakaria Y Abd Elmageed, Hamed I Ali
Protein kinases are promising therapeutic targets for cancer therapy. Here, we applied multiple approaches to optimize the potency and selectivity of our reported alloxazine scaffold. Flexible moieties at position 2 of the hetero-tricyclic system were incorporated to fit into the ATP binding site and extend to the adjacent allosteric site and selectively inhibit protein kinases. This design led to potential selective inhibition of ABL1, CDK1/Cyclin A1, FAK, and SRC kinase by 30-59%. Cytotoxicity was improved by ∼50 times for the optimized lead (10b; IC50  = 40 nM) against breast cancer (MCF-7) cells...
April 17, 2018: European Journal of Medicinal Chemistry
Reham M Dawood, Mai Abd El-Meguid, Marwa K Ibrahim, Noha G Bader El Din, Ahmed Barakat, Khaled El-Wakeel, Mohamed Darwish Ahmed Abd Alla, George Y Wu, Mostafa K El Awady
BACKGROUND: Liver fibrosis results from a wound healing response to chronic injury, which leads to excessive matrix deposition. Genome wide association studies have showen transcriptional dysregulation in mild and severe liver fibrosis. Recent studies suggested that genetic markers may be able to define the exact stage of liver fibrosis. AIM: To define genes or genetic pathways that could serve as markers for staging or as therapeutic targets to halt progression of liver fibrosis...
April 20, 2018: Gene
Nadia A Mohamed, Nahed A Abd El-Ghany
Four chemically modified chitosan derivatives 1-4 were designed and synthesized via a series of four reactions; first by reaction with benzaldehyde to protect its amino groups (Derivative 1), second by reaction with epichlorohydrine (Derivative 2), third by reaction with aminobenzhydrazide (Derivative 3), and forth by removing of benzaldehyde to restore the free amino groups on the chitosan (Derivative 4). Two multi-walled carbon nanotube (MWCNT) biocomposites based on Derivative 4 were also prepared. The structure of the prepared derivatives and MWCNT composites was elucidated using elemental analyses, FTIR, XRD, SEM and TEM...
April 20, 2018: International Journal of Biological Macromolecules
Alaa Zidan, Marie Cordier, Abeer M El-Naggar, Nour E A Abd El-Sattar, Mohamed Ali Hassan, Ali Khalil Ali, Laurent El Kaïm
Propargylation of Ugi adducts under the addition of excess sodium hydride in DMSO leads to direct formation of pyrrolidinone enamides, which are useful precursors of iminium intermediates and may be trapped by various nucleophiles. This approach has been applied to the formation of benzoindolizidine alkaloids with high diversity via a Ugi/propargylation/Pictet-Spengler cyclization.
April 23, 2018: Organic Letters
Wan Nuraini Wan Hasan, Kok-Yong Chin, James Jam Jolly, Norzana Abd Ghafar, Ima Nirwana Soelaiman
BACKGROUND: Osteoporosis is a silent skeletal disease characterized by low bone mass and destruction of skeletal microarchitecture, leading to an increased fracture risk. This occurs due to an imbalance in bone remodelling, whereby the rate of bone resorption is greater than bone formation. Mevalonate pathway, previously known to involve in cholesterol synthesis, is an important regulatory pathway for bone remodelling. OBJECTIVE: This review aimed to provide an overview of the relationship between mevalonate pathway and bone metabolism, as well as agents which act through this pathway to achieve their therapeutic potential...
April 23, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
Liang Hooi Lim, Zamzuri Idris, Faruque Reza, Wan Mohd Nazaruddin Wan Hassan, Laila Abd Mukmin, Jafri Malin Abdullah
The role of language in communication plays a crucial role in human development and function. In patients who have a surgical lesion at the functional language areas, surgery should be intricately planned to avoid incurring further morbidity. This normally requires extensive functional and anatomical mappings of the brain to identify regions that are involved in language processing and production. In our case report, regions of the brain that are important for language functions were studied before surgery by employing (a) extraoperative methods such as functional magnetic resonance imaging, transmagnetic stimulation, and magnetoencephalography; (b) during the surgery by utilizing intraoperative awake surgical methods such as an intraoperative electrical stimulation; and (c) a two-stage surgery, in which electrical stimulation and first mapping are made thoroughly in the ward before second remapping during surgery...
April 2018: Asian Journal of Neurosurgery
Shahnorbanun Sahran, Dheeb Albashish, Azizi Abdullah, Nordashima Abd Shukor, Suria Hayati Md Pauzi
OBJECTIVE: Feature selection (FS) methods are widely used in grading and diagnosing prostate histopathological images. In this context, FS is based on the texture features obtained from the lumen, nuclei, cytoplasm and stroma, all of which are important tissue components. However, it is difficult to represent the high-dimensional textures of these tissue components. To solve this problem, we propose a new FS method that enables the selection of features with minimal redundancy in the tissue components...
April 18, 2018: Artificial Intelligence in Medicine
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