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https://www.readbyqxmd.com/read/28649320/food-allergy-in-a-child-with-de-novo-kat6a-mutation
#1
Varpu Elenius, Tuire Lähdesmäki, Marja Hietala, Tuomas Jartti
Crying combined with miscellaneous gastrointestinal symptoms are typical symptoms of infant with food allergy, but are also common among children with abnormal neurological development. Mutations in KAT6A gene is known to cause a syndrome characterized by developmental delay, hypotonia, cardiac defects, microcephaly, specific facial features and early feeding problems. However, these feeding problems have not earlier been specified. We present the first reported case of a DBPCFC confirmed food allergy in a child with KAT6A mutation whose feeding problems resolved with elimination diet...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28646842/fruit-and-vegetable-consumption-in-high-school-students-in-bandar-abbas-iran-an-application-of-the-trans-theoretical-model
#2
Sayed Hossein Davoodi, Zahra Hosseini, Teamur Aghamolaei, Mehdi Zare, Amin Ghanbarnejad
BACKGROUND: A diet rich in fruits and vegetables is of a great importance, especially to adolescents due to their need for nutrients and their rapid growth. The aim of this study was to investigate the relationship between decisional balance and self-efficacy with stages of change for fruit and vegetable consumption in high school students in Bandar Abbas, Iran. METHODS: In this descriptive-analytical study, data were collected from 345 students studying in eight high schools of Bandar Abbas who were selected through multistage sampling...
June 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28646832/diet-for-women-with-irritable-bowel-syndrome-a-preliminary-study
#3
Diana Wasiluk, Lucyna Ostrowska, Ewa Stefańska, Agnieszka Janke, Grażyna Jurkowska
Background: Irritable Bowel Syndrome (IBS) is one of the most frequent digestive system diseases, of various medical signs. It is assumed that proper life style, including appropriate, rational diet is a factor helpful for treating such a disorder. Objective: The purpose of this paper was to assess the selected dietary habits, and to evaluate the nutritional value of daily food rations for patients with a mixed type of Irritable Bowel Syndrome. Material and Methods: The questionnaire survey involved a group of 32 women suffering from a mixed type of Irritable Bowel Syndrome (The Rome III Diagnostic Criteria were used to diagnose the disease)...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28644352/elevated-serum-tissue-transglutaminase-antibodies-in-children-with-eosinophilic-esophagitis
#4
Anna K Le Fevre, Marjorie M Walker, Amir Hadjiashrafy, Rani Bhatia, Joerg Mattes, Nicholas J Talley, Scott Nightingale
OBJECTIVES: This study compared the clinical and histopathological characteristics of children with eosinophilic esophagitis (EoE) and elevated anti-transglutaminase (TTG Ab) with those with EoE and normal TTG Ab titres. METHODS: Single-center chart and blinded histopathological review of patients diagnosed with EoE for a 4-year period, who had esophageal and duodenal biopsies taken at time of endoscopy, and TTG Ab measured within 6 months of biopsy. Patients with histology-proven CD were excluded...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28644349/filaggrin-and-periostin-expression-is-altered-in-eosinophilic-esophagitis-and-normalized-with-treatment
#5
Ekaterini Politi, Aspasia Angelakopoulou, Dimitra Grapsa, Maria Zande, Kalliopi Stefanaki, Ioanna Panagiotou, Eleftheria Roma, Ekaterini Syrigou
OBJECTIVES: Previous data have suggested that filaggrin (FLG) and periostin (POSTN) genes may be dysregulated in eosinophilic esophagitis (EoE). We aimed to further evaluate the expression patterns of FLG and POSTN proteins in esophageal tissue samples of patients with EoE, as compared to those of patients with gastroesophageal reflux disease (GERD) and normal controls. METHODS: A total of 61 prospectively collected cases, including 40 children with EoE and 21 children with GERD, and a control group of 14 sex- and age-matched healthy children were enrolled...
July 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28642028/discovery-of-novel-5-oxa-2-6-diazaspiro-3-4-oct-6-ene-derivatives-as-potent-selective-and-orally-available-somatostatin-receptor-subtype-5-sstr5-antagonists-for-treatment-of-type-2-diabetes-mellitus
#6
Hideki Hirose, Takeshi Yamasaki, Masaki Ogino, Ryo Mizojiri, Yumiko Tamura-Okano, Hiroaki Yashiro, Yo Muraki, Yoshihide Nakano, Jun Sugama, Akito Hata, Shinji Iwasaki, Masanori Watanabe, Tsuyoshi Maekawa, Shizuo Kasai
Somatostatin receptor subtype 5 (SSTR5) has emerged as a novel attractive drug target for type 2 diabetes mellitus. Starting from N-benzyl azetidine derivatives 1 and 2 as in-house hit compounds, we explored the introduction of a carboxyl group into the terminal benzene of 1 to enhance SSTR5 antagonistic activity by the combination of the substituents at the 3-position of the isoxazoline. Incorporation of a carboxyl group at the 4-position of the benzene ring resulted in a significant enhancement in potency, however, the 4-benzoic acid derivative 10c exhibited moderate human ether-a-go-go related gene (hERG) inhibitory activity...
June 9, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28627063/beet-pulp-intake-and-hairball-faecal-excretion-in-mixed-breed-shorthaired-cats
#7
B A Loureiro, M Monti, R S Pedreira, A Vitta, P D G Pacheco, T C Putarov, A C Carciofi
Hairball formation may induce vomiting and intestinal obstruction in predisposed cats. Some insoluble fibres as sugarcane fibre and cellulose can prevent hairball formation. The aim of this study was to evaluate the effect of beet pulp consumption, a moderate soluble and fermentable fibre source, on faecal trichobezoars excretion in adult shorthaired cats fed kibble diets. Eighteen mixed-breed shorthaired cats and three extruded diets were used as follows: a basal diet without added fibre source (PB0-8.8% dietary fibre); BP8-8% inclusion of beet pulp (17...
June 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28616819/-safe-foods-or-fear-foods-the-implications-of-food-avoidance-in-college-students-from-low-and-middle-income-countries
#8
C James, A Harrison, A Seixas, M Powell, S Pengpid, K Peltzer
PURPOSE: The primary objective of this study was to explore if self-reported food avoidance (fats, carbohydrates and protein) exists among college students in low- and middle-income countries (LMICs) and its relationship with body mass index (BMI), dieting, mood/anxiety symptoms, physical activities and general health knowledge. METHODS: This study is a subset (N = 6096) of a larger 26 LMICs cross-sectional survey, which consisted of 21,007 college students. We ascertained socio-demographic information, food avoidance, physical activities, dieting behaviours, depressive and PTSD symptoms, and recorded anthropometric measurements...
June 14, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28615947/treatment-of-secondary-hyperparathyroidism-the-clinical-utility-of-etelcalcetide
#9
REVIEW
Mario Cozzolino, Andrea Galassi, Ferruccio Conte, Michela Mangano, Luca Di Lullo, Antonio Bellasi
Secondary hyperparathyroidism (SHPT), a very frequent, severe, and worsening complication of chronic kidney disease, is characterized by high serum parathyroid hormone (PTH), parathyroid gland hyperplasia, and disturbances in mineral metabolism. Clinically, SHPT shows renal osteodystrophy, vascular calcification, cardiovascular damage, and fatal outcome. Calcium-sensing receptor (CaSR) is the main physiological regulator of PTH secretion; its activation by calcium rapidly inhibits PTH. Another important player in regulating mineral metabolism is vitamin D receptor (VDR), which is under the influence of vitamin D and influences the intestinal absorption of calcium and phosphate, PTH gene expression, and bone calcium mobilization...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28613874/distinguishing-cis-and-trans-isomers-in-intact-complex-lipids-using-electron-impact-excitation-of-ions-from-organics-eieio-mass-spectrometry
#10
Takashi Baba, J Larry Campbell, J C Yves Le Blanc, Paul R S Baker
We present a mass spectrometry-based method for the identification of cis and trans double bond isomers within intact complex lipid mixtures using Electron Impact Excitation of Ions from Organics (EIEIO) mass spectrometry. EIEIO involves irradiating singly charged lipid ions with electrons having kinetic energies of 5-16 eV. The resulting EIEIO spectra can be used to discern cis and trans double bond isomers by virtue of the differences in the fragmentation patterns at the carbon-carbon single bonds neighboring the double bonds...
June 14, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28608048/six-food-elimination-diet-and-topical-steroids-are-effective-for-eosinophilic-esophagitis-a-meta-regression
#11
Cary C Cotton, Swathi Eluri, W Asher Wolf, Evan S Dellon
BACKGROUND: Topical corticosteroids or six-food elimination diet is recommended as initial therapy for eosinophilic esophagitis (EoE). AIMS: We aimed to summarize published manuscripts that report outcomes of these therapies for EoE. METHODS: We performed a systematic review in MEDLINE, Web of Science, and Embase of published manuscripts describing topical fluticasone, topical budesonide, and six-food elimination diet as therapies for EoE...
June 12, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28607454/insulin-sparing-and-fungible-effects-of-e4orf1-combined-with-an-adipocyte-targeting-sequence-in-mouse-models-of-type-1-and-type-2-diabetes
#12
I-S Yoon, S Park, R-H Kim, H L Ko, J-H Nam
Obesity impairs glycemic control and causes insulin resistance and type 2 diabetes. Adenovirus 36 (Ad36) infection can increase the uptake of excess glucose from blood into adipocytes by increasing GLUT4 translocation through the Ras-Akt signaling pathway, which bypasses PI3K-Akt-mediated insulin receptor signaling. E4orf1, a viral gene expressed early during Ad36 infection, is responsible for this insulin-sparing effect and may be an alternative target for improving insulin resistance. To deliver the gene to adipocytes only, we connected the adipocyte-targeting sequence (ATS) to the 5' end of E4orf1 (ATS-E4orf1)...
June 13, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28603055/efficacy-of-a-4-food-elimination-diet-for-children-with-eosinophilic-esophagitis
#13
A F Kagalwalla, J B Wechsler, K Amsden, S Schwartz, M Makhija, A Olive, C M Davis, M Manuel-Rubio, S Marcus, M Sulkowski, K Johnson, J N Ross, M E Riffle, M Groetch, H Melin-Aldana, D Schady, H Palac, K-Y A Kim, B K Wershil, M H Collins, M Chehade
BACKGROUND & AIMS: A 6-food elimination diet induces remission in most children and adults with eosinophilic esophagitis (EoE). The effectiveness of empiric elimination of only 4 foods has not been studied in children. We performed a prospective observational outcome study in children with EoE treated with dietary exclusion of cow's milk, wheat, egg, and soy. The objective was to assess the clinical, endoscopic, and histologic efficacy of this treatment in EoE. METHODS: We recruited children (1-18 years old, diagnosed per consensus guidelines) from 4 medical centers...
June 8, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28585690/satisfying-america-s-fruit-gap-summary-of-an-expert-roundtable-on-the-role-of-100-fruit-juice
#14
REVIEW
Carol Byrd-Bredbenner, Mario G Ferruzzi, Victor L Fulgoni, Robert Murray, Elizabeth Pivonka, Taylor C Wallace
The 2015 to 2020 Dietary Guidelines for Americans (DGAs) recognize the role of 100% fruit juice in health and in helping people meet daily fruit recommendations and state that 100% fruit juice is a nutrient-dense beverage that should be a primary choice, along with water and low-fat/fat-free milk. The DGAs note that children are consuming 100% fruit juice within recommendations (that is, 120 to 180 mL/d for children aged 1 to 6 y and 236 to 355 mL/d for children aged 7 to 18 y). Evidence shows that compared to nonconsumers, those who consume 100% fruit juice come closer to meeting daily fruit needs and have better diet quality...
June 6, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28585232/in-vitro-in-silico-based-analysis-of-the-dose-dependent-in-vivo-estrogenicity-of-the-soy-phytoestrogen-genistein-in-humans
#15
Rungnapa Boonpawa, Albertus Spenkelink, Ans Punt, Ivonne M C M Rietjens
BACKGROUND AND PURPOSE: In vivo estrogenicity of genistein and its glycoside genistin is still under debate. The present study aimed to develop a physiologically based kinetic (PBK) model that provides insight in dose-dependent plasma concentrations of genistein aglycone and its metabolites and enables prediction of in vivo estrogenic effective dose levels of genistein and genistin in humans. EXPERIMENTAL APPROACH: A PBK model for genistein and genistin in humans was developed based on in vitro metabolic parameters...
June 5, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28576119/nicotine-stimulates-collagen-type-i-expression-in-lung-via-%C3%AE-7-nicotinic-acetylcholine-receptors
#16
Glenn W Vicary, Jeffrey D Ritzenthaler, Tanmay S Panchabhai, Edilson Torres-González, Jesse Roman
BACKGROUND: Tobacco-related chronic lung diseases are characterized by alterations in lung architecture leading to decreased lung function. Knowledge of the exact mechanisms involved in tobacco-induced tissue remodeling and inflammation remains incomplete. We hypothesize that nicotine stimulates the expression of extracellular matrix proteins, leading to relative changes in lung matrix composition, which may affect immune cells entering the lung after injury. METHODS: Pulmonary fibroblasts from wildtype and α7 nicotinic acetylcholine receptor knockout (α7KO) mice were exposed to nicotine and examined for collagen type 1 mRNA and protein expression...
June 2, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28573837/public-health-intervention-over-four-decades-for-the-children-in-the-australian-capital-territory-have-we-reached-the-point-of-diminishing-returns
#17
I Sohal, E Kruger, M Tennant
BACKGROUND: Most of the developed world has seen some substantial improvements in the dental health of children over the past four decades owing to advances in service access, fluoride exposure, socio-economic development and improved diets, with the DMFT score of 12 year-olds dropping from well over 10 down to around one. AIM: To examine the question of advancing dental health for children even further using the same set of tools as we have to date by asking the question: Have we come to a point of diminishing returns? The study examines the long-term, near optimum settings of the known public dental health variables in the Australian Capital Territory...
June 2017: Community Dental Health
https://www.readbyqxmd.com/read/28552742/oxalobacter-formigenes-colonization-normalizes-oxalate-excretion-in-a-gastric-bypass-model-of-hyperoxaluria
#18
Benjamin K Canales, Marguerite Hatch
BACKGROUND: Hyperoxaluria and oxalate kidney stones frequently develop after Roux-en-Y gastric bypass (RYGB). Oxalobacter formigenes can degrade ingested oxalate. OBJECTIVES: Examine the effect of O. formigenes wild rat strain (OXWR) colonization on urinary oxalate excretion and intestinal oxalate transport in a hyperoxaluric RYGB model. SETTING: Basic Science Laboratory, United States. METHODS: At 21 weeks of age, 28 obese male Sprague-Dawley rats survived Sham (n = 10) or RYGB (n = 18) surgery and were maintained on a 1...
March 23, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28549059/elimination-diet-and-the-development-of-multiple-tree-nut-allergies
#19
Arnon Elizur, Jennifer B Bollyky, Whitney M Block
BACKGROUNDDespite its high prevalence, relatively little is known about the characteristics of patients with multiple tree-nuts allergies.METHODSPatients (n=60, aged 4-15 years), recruited for a multiple food (tree-nuts, peanut, milk, egg, soy, sesame and wheat) oral immunotherapy (OIT) study, filled a questionnaire on their initial allergy evaluation. Medical records were reviewed. At OIT enrollment (median interval, 7.5 years), patients underwent oral food challenges (OFC) to foods still eliminated.RESULTSThere was significantly less evidence for eliminating tree-nuts compared to other foods, as reflected by lower rate of acute reaction to the offending food, either as the trigger for initial allergy evaluation (5...
May 26, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28546563/microbiota-in-t-cell-homeostasis-and-inflammatory-diseases
#20
REVIEW
Naeun Lee, Wan-Uk Kim
The etiology of disease pathogenesis can be largely explained by genetic variations and several types of environmental factors. In genetically disease-susceptible individuals, subsequent environmental triggers may induce disease development. The human body is colonized by complex commensal microbes that have co-evolved with the host immune system. With the adaptation to modern lifestyles, its composition has changed depending on host genetics, changes in diet, overuse of antibiotics against infection and elimination of natural enemies through the strengthening of sanitation...
May 26, 2017: Experimental & Molecular Medicine
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