keyword
https://read.qxmd.com/read/38533276/primary-hyperparathyroidism-in-young-and-adolescents-alike-or-unlike-adult-hyperparathyroidism-a-series-from-south-india
#1
JOURNAL ARTICLE
Dhalapathy Sadacharan, Smitha S Rao, Shriraam Mahadevan, G Shanmugasundar, S Murthy, Shruti Chandrashekaran, Vijay Bhaskar Reddy, Bharath Ramji
BACKGROUND: Primary hyperparathyroidism (PHPT) is a common endocrine condition but rare in the pediatric and adolescent populations. The presentations can be unique, accounting for significant morbidity in the case of untimely detection. AIM: To study surgically treated pediatric PHPT retrospectively. METHODS: Surgically treated children of PHPT up to 20 years of age between 2010 to 2022 were analyzed. All of them were operated on by an endocrine surgeon and team...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532850/a-case-report-of-primary-hyperparathyroidism-in-an-adolescent-during-ramadan-fast
#2
Ujunwa Justina Eze, Sundus Elfadil
Primary hyperparathyroidism is rare in children and usually presents with nonspecific symptoms. Ramadan fasting has been reported to unmask the diagnosis of primary hyperparathyroidism. A 15-year-old boy presented to the clinic for an emergency department follow up visit. He had started Ramadan fasting a week before his presentation to the clinic. He reported unintentional weight loss, abdominal pain, constipation, frequent headaches, exercise intolerance, tiredness, and palpitations. Physical examination was unremarkable except that he looked tired...
2024: SAGE Open Medical Case Reports
https://read.qxmd.com/read/38525667/predicting-tumor-volume-in-primary-hyperparathyroidism-from-preoperative-clinical-data
#3
JOURNAL ARTICLE
Tomoyoshi Nakai, Kiyomi Horiuchi, Takahiro Okamoto
CONTEXT: Primary hyperparathyroidism (PHPT) is an endocrine disorder that is treated surgically, and some correlation between the size of the responsible lesion and preoperative clinical data is assumed. The purpose of this study was to predict tumor volume of the lesion responsible for PHPT from preoperative clinical data. METHODS: Participants comprised patients with surgically treated PHPT who underwent initial surgery in our department between January 2000 and December 2021...
March 25, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38524572/unusual-body-weight-loss-due-to-primary-hyperparathyroidism-a-case-study-with-literature-review
#4
Yan-Yu Lin, Shuen-Fu Weng, Ting-Teng Yang, Yi-Wei Lee, Ju-Han Liu, Yu-Shan Hsieh
Brown tumors (osteitis fibrosa cystica) are rare pathognomonic signs that occur in patients with primary hyperparathyroidism (PHPT). Brown tumors can exist in multiple bones and can easily be misdiagnosed as a metastatic tumor or multiple myeloma. It is also localized in the forearm, humerus, and leg. The symptoms of hypercalcemia, pathologic fracture, and bodyweight loss may increase the diagnostic difficulty of brown tumors because multiple myeloma and bone metastasis also show the same symptoms. We studied a 68-year-old woman who had experienced unusual bodyweight loss in the past 6 months (56kg-40kg) and bone pain...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38520268/a-rare-ectopic-parathyroid-adenoma-in-the-prevertebral-space
#5
JOURNAL ARTICLE
Alex Tran, Manual Molina-Vega
Ectopic parathyroid adenomas are an uncommon etiology of primary hyperparathyroidism. We present a case of a patient admitted to the hospital with severe hypercalcemia and elevated parathyroid hormone levels, in whom imaging revealed two distinct parathyroid masses in the prevertebral space, representing a rare and atypical location for parathyroid tissue. This case highlights the importance of considering ectopic parathyroid adenomas as a potential cause of hyperparathyroidism and discusses the diagnostic challenges and management strategies associated with such cases...
March 23, 2024: American Surgeon
https://read.qxmd.com/read/38517662/intraoperative-radio-guided-localization-of-parathyroid-adenomas-using-3d-freehand-spect-technology
#6
JOURNAL ARTICLE
Stathis Anesidis, Ioanna Akrida, Marina Michalaki, Dimitrios Apostololpoulos, Nikolaos Papathanasiou, Nikolaos Benetatos, Christina Kalogeropoulou, Konstantinos Panagopoulos, Ioannis Maroulis
Parathyroidectomy for primary hyperparathyroidism (PHPT) could have poor outcomes, even with accurate preoperative localization of the adenomas, because their intraoperative localization can be challenging. Freehand single photon emission computed tomography (fhSPECT) is a new technique for radio-guided intraoperative navigation. Its use during parathyroidectomy could be useful and such data are limited. We herein present our experience on the feasibility of fhSPECT for intraoperative detection of abnormal parathyroid glands...
March 22, 2024: Updates in Surgery
https://read.qxmd.com/read/38509667/protein-signatures-of-parathyroid-adenoma-according-to-tumor-volume-and-functionality
#7
JOURNAL ARTICLE
Sung Hye Kong, Jeong Mo Bae, Jung Hee Kim, Sang Wan Kim, Dohyun Han, Chan Soo Shin
BACKGROUND: Parathyroid adenoma (PA) is a common endocrine disease linked to multiple complications, but the pathophysiology of the disease remains incompletely understood. The study aimed to identify the key regulator proteins and pathways of PA according to functionality and volume through quantitative proteomic analyses. METHODS: We conducted a retrospective study of 15 formalin-fixed, paraffin-embedded PA samples from tertiary hospitals in South Korea. Proteins were extracted, digested, and the resulting peptides were analyzed using liquid chromatography-tandem mass spectrometry...
March 21, 2024: Endocrinology and Metabolism
https://read.qxmd.com/read/38489132/biochemical-characteristics-and-clinical-manifestation-of-normocalcemic-primary-hyperparathyroidism
#8
JOURNAL ARTICLE
Inna Yankova, Lora Lilova, Daniela Petrova, Inna Dimitrova, Mariya Stoynova, Alexander Shinkov, Roussanka Kovatcheva
BACKGROUND: Normocalcemic primary hyperparathyroidism (nPHPT) is a condition characterized by persistently high levels of parathyroid hormone (PTH) and normal serum calcium levels in the absence of other causes for secondary hyperparathyroidism. The aim of the present study was to assess the clinical presentation and the biochemical characteristics in patients with nPHPT and to compare them with those in patients with hypercalcemic PHPT (hPHPT). MATERIALS AND METHODS: The study included 316 patients (277 women and 39 men, average age 58...
March 15, 2024: Endocrine
https://read.qxmd.com/read/38471398/high-lymphocyte-signature-genes-expression-in-parathyroid-endocrine-cells-and-its-downregulation-linked-to-tumorigenesis
#9
JOURNAL ARTICLE
Chong Geng, Junjun Liu, Bingzhou Guo, Kailin Liu, Pengfei Gong, Bao Wang, Qiang Wan, Liang Sun, Jiajun Zhao, Yongfeng Song
BACKGROUND: To date, because of the difficulty in obtaining normal parathyroid gland samples in human or in animal models, our understanding of this last-discovered organ remains limited. METHODS: In the present study, we performed a single-cell transcriptome analysis of six normal parathyroid and eight parathyroid adenoma samples using 10 × Genomics platform. FINDINGS: We have provided a detailed expression atlas of parathyroid endocrine cells...
March 11, 2024: EBioMedicine
https://read.qxmd.com/read/38449925/long-term-calcium-monitoring-post-parathyroidectomy-for-primary-hyperparathyroidism
#10
JOURNAL ARTICLE
William Jenkins, Edward Chisholm, Faith Protts
BACKGROUND:  Cure rates following parathyroidectomy for primary hyperparathyroidism are excellent, with well-documented low short-term recurrence rates of hypercalcaemia. Rates of long-term recurrence have been investigated to a lesser extent, but recent studies have reported higher than anticipated rates. This study sought to evaluate recurrence rates at more than four years post seemingly corrective surgery and depending on the findings, propose whether recommendations of annual calcium monitoring post-parathyroidectomy are appropriate based on the limited data available at the time of formulating guidelines...
February 2024: Curēus
https://read.qxmd.com/read/38440124/hyperparathyroidism-jaw-tumor-syndrome-an-unforeseen-diagnosis
#11
Asande Zama, Elsie C Kruger, Annalise E Zemlin, Magda Conradie
Asymptomatic primary hyperparathyroidism (PHPT) is often missed in developing nations due to limited formal healthcare exposure and biochemical screening programs. Many patients are thus only diagnosed once symptomatic. We present a 32-year-old female who developed bony protrusions in her jaw during pregnancy, resulting in a stillbirth. Three months later, during a dental consultation for worsening toothache, jaw abnormalities were detected. Radiological studies revealed bilateral mandibular radiolucent lesions, and bone biopsy confirmed histological features consistent with a brown tumor...
March 2024: JCEM Case Rep
https://read.qxmd.com/read/38433618/clinical-characteristics-and-outcomes-of-patients-operated-for-primary-hyperparathyroidism-at-tampere-university-hospital-in-2017-2018
#12
JOURNAL ARTICLE
Jussi Tamski, Tommi Hakala, Heini Huhtala, Saara Metso
BACKGROUND AND OBJECTIVE: Studies on the outcomes of parathyroid surgery are scarce. The aim was to report the outcomes and to study the association between pre- and peri-operative information with the outcomes of patients operated for primary hyperparathyroidism. METHODS: This was a retrospective, descriptive study with unselected patients treated surgically for primary hyperparathyroidism from a catchment population of 704,500 in Finland. Data were acquired from the electronic hospital registers based on parathyroid surgery procedure codes between 1 January 2017 and 31 December 2018...
March 4, 2024: Scandinavian Journal of Surgery: SJS
https://read.qxmd.com/read/38433542/-hyperparathyroidism-of-different-genesis-in-young-patients-with-turner-syndrome-case-series-and-brief-review
#13
JOURNAL ARTICLE
I D Ozhimalov, T K Karavaynaya, Ju D Fedorova, A M Gorbacheva, E E Bibik, I S Maganeva, A К Eremkina, N G Mokrysheva
Hyperparathyroidism is a syndrome characterized by an excessive secretion of parathyroid hormone. Etiologically, hyperparathyroidism is subdivided into primary hyperparathyroidism, which develops as a result of parathyroid adenoma, carcinoma or hyperplasia, and secondary hyperparathyroidism, which happens as a compensatory response to a hypocalcemia caused by condition outside the parathyroid glands. Turner syndrome may also be accompanied by mineral metabolism disorders of various etiology. An association of hyperparathyroidism and Turner syndrome is interesting because of multifactorial impact on bone mineral density, but only few cases of such coexistence have been previously described in the literature...
February 28, 2024: Problemy E̊ndokrinologii
https://read.qxmd.com/read/38433078/don-t-chase-the-adenoma-a-probabilistic-approach-to-imaging-before-parathyroidectomy
#14
JOURNAL ARTICLE
Nicole Lunardi, Allison Jacob, Dawn Elfenbein, David F Schneider, Kristin Long, Simon A Holoubek, Erin MacKinney, Alexander Chiu, Rebecca S Sippel, Courtney J Balentine
BACKGROUND: Preoperative imaging before parathyroidectomy can localize adenomas and reduce unnecessary bilateral neck explorations. We hypothesized that (1) the utility of preoperative imaging varies substantially depending on the preoperative probability of having adenoma(s) and (2) that a selective imaging approach based on this probability could avoid unnecessary patient costs and radiation. METHODS: We analyzed 3,577 patients who underwent parathyroidectomy for primary hyperparathyroidism from 2001 to 2022...
March 2, 2024: Surgery
https://read.qxmd.com/read/38429880/incidental-thymoangiolipoma-found-during-parathyroidectomy-for-primary-hyperparathyroidism-a-finding-that-may-mimic-parathyroid-adenoma
#15
Samuel Thompson, Elan Novis, Julia Low, Tamara Preda
No abstract text is available yet for this article.
March 1, 2024: ANZ Journal of Surgery
https://read.qxmd.com/read/38420233/phosphaturic-mesenchymal-tumor-in-the-proximal-femur-presenting-as-tumor-induced-osteomalacia-a-case-report-and-literature-review
#16
Shubham Tungenwar, S Subith, Moin Mukadam, Sagar Kokate, Siddharth Gunay
INTRODUCTION: An uncommon medical disorder known as tumor-induced osteomalacia (TIO) is characterized by severe hypophosphatemia, renal phosphate wasting, and osteomalacia due to a tumor. TIO has recently been linked to a particular kind of tumor known as phosphaturic mesenchymal tumor (PMT). PMTs release phosphatonins, such as fibroblast growth factor-23 (FGF23), which elevates serum levels of FGF23, leading to phosphate wasting and osteomalacia. However, due to their infrequent occurrence and vague symptoms, such as bone pain, myopathies, arthralgias, fractures, and weakness, the diagnosis of PMTs is often delayed or misdiagnosed...
February 2024: Journal of Orthopaedic Case Reports
https://read.qxmd.com/read/38419822/recurrent-urolithiasis-revealing-primary-hyperparathyroidism-in-a-nephrology-department
#17
Hajji Meriam, Hayet Kaaroud, Rahma Karray, Fethi Ben Hamida, Kahena Bouzid, Ezzeddine Abderrahim
BACKGROUND: Urinary lithiasis constitutes a recurrent pathology affecting a relatively young population. The risk of progression to chronic renal failure and the cost of treatment are the most important issues. Primary hyperparathyroidism (PHPT) is responsible for urolithiasis and nephrocalcinosis in 7% of patients, and it represents the 7th cause of urolithiasis in Tunisia. Unfortunately, it remains an underdiagnosed pathology although it is curable. We aim to determine the clinical, biological, therapeutic, and evolutionary particularities of urinary lithiasis associated with PHPT in a nephrology setting...
2024: Case Reports in Nephrology
https://read.qxmd.com/read/38412311/24-hour-urine-calcium-predicts-reduced-fracture-incidence-and-improved-bmd-after-surgery-for-primary-hyperparathyroidism
#18
JOURNAL ARTICLE
Martin Nilsson, Kristina E Åkesson, Mark Thier, Erik Nordenström, Martin Almquist, Anders Bergenfelz
CONTEXT: Contemporary patients with primary hyperparathyroidism are diagnosed with milder disease than previously. Clinical and biochemical factors predictors with impact on fracture incidence and bone mineral density after surgery have not been firmly established. OBJECTIVE: To investigate predictors of fracture incidence and bone mineral density preoperatively and after surgery for primary hyperparathyroidism (pHPT). DESIGN: Prospectively collected surgical cohort with matched population controls...
February 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38396977/insights-into-hyperparathyroidism-jaw-tumour-syndrome-from-endocrine-acumen-to-the-spectrum-of-cdc73-gene-and-parafibromin-deficient-tumours
#19
REVIEW
Ana-Maria Gheorghe, Oana-Claudia Sima, Alexandru Florin Florescu, Adrian Ciuche, Claudiu Nistor, Florica Sandru, Mara Carsote
A total of 1 out of 10 patients with primary hyperparathyroidism (PHP) presents an underlying genetic form, such as multiple endocrine neoplasia types 1, 2A, etc., as well as hyperparathyroidism-jaw tumour syndrome (HJT). We aimed to summarise the recent data, thus raising more awareness regarding HJT, from the clinical perspective of PHP in association with the challenges and pitfalls of CDC73 genetic testing and parafibromin staining. This narrative review included a sample-focused analysis from the past decade according to a PubMed search...
February 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38391401/hypercalcemic-crisis-due-to-a-giant-intrathyroidal-parathyroid-adenoma-with-postsurgical-severe-hypocalcemia-and-hungry-bone-syndrome-a-case-report
#20
Vasileios Papanikos, Elli Papadodima, Dimitra Bantouna, Rodis D Paparodis, Sarantis Livadas, Nicholaos Angelopoulos, Evangelos Karvounis
BACKGROUND: Parathyroid adenoma is the most common cause of hypercalcemia and rarely leads to a hypercalcemic crisis, which is an unusual endocrine emergency that requires timely surgical excision. CASE PRESENTATION: A 67-year-old male was admitted to the ER of the Euroclinic Hospital, Athens, Greece, because of elevated calcium levels and a palpable right-sided neck mass, which were accompanied by symptoms of nausea, drowsiness, and weakness for six months that increased prior to our evaluation...
January 22, 2024: Clinics and Practice
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