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Parathyroid adenoma

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https://www.readbyqxmd.com/read/29775451/-recurrent-urolithiasis-as-a-symptom-of-primary-hyperparathyroidism-in-a-16-year-old-boy
#1
Monika Wojciechowska, Beata Bieniaś, Aleksandra Sobieszczańska-Droździel, Anna Wieczorkiewicz-Płaza, Iwona Beń-Skowronek, Przemysław Sikora
Primary hyperparathyroidism is one of the most common endocrine diseases, however, it is rare in children. In most cases, it is caused by adenoma of these organs. Its most common complications include urolithiasis, nephrocalcinosis and osteoporosis. CASE REPORT: A 16-year-old patient was admitted to our Clinic because of his first-ever renal colic. The ultrasound examination revealed rightsided hydronephrosis caused by the presence of 9 mm stone in the upper part of the right ureter. In addition, the presence of 8 mm stone in the middle calyx of the left kidney was found...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29755684/large-deletion-at-the-cdc73-gene-locus-and-search-for-predictive-markers-of-the-presence-of-a-cdc73-genetic-lesion
#2
Lucia Anna Muscarella, Daniela Turchetti, Andrea Fontana, Filomena Baorda, Orazio Palumbo, Annamaria la Torre, Danilo de Martino, Renato Franco, Nunzia Simona Losito, Andrea Repaci, Uberto Pagotto, Luigia Cinque, Massimiliano Copetti, Maria Grazia Chiofalo, Luciano Pezzullo, Paolo Graziano, Alfredo Scillitani, Vito Guarnieri
The Hyperparathyroidism with Jaw-Tumours syndrome is caused by mutations of the CDC73 gene: it has been suggested that early onset of the disease and high Ca2+ levels may predict the presence of a CDC73 mutation. We searched for large deletions at the CDC73 locus in patients with: HPT-JT (nr 2), atypical adenoma (nr 7) or sporadic parathyroid carcinoma (nr 11) with a specific MLPA and qRT-PCR assays applied on DNA extracted from whole blood. A Medline search in database for all the papers reporting a CDC73 gene mutation, clinical/histological diagnosis, age at onset, Ca2+ , PTH levels for familial/sporadic cases was conducted with the aim to possibly identify biochemical/clinical markers predictive, in first diagnosis, of the presence of a CDC73 gene mutation...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29751932/cervical-haematoma-secondary-to-spontaneous-bleeding-of-parathyroid-adenoma
#3
Alberto Martínez-Martínez, Jade García-Espinosa
No abstract text is available yet for this article.
May 8, 2018: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/29739732/inherited-deletion-of-1q-hyperparathyroidism-and-signs-of-y-chromosomal-influence-in-a-patient-with-turner-syndrome
#4
Alejandro F Siller, Alex Shimony, Marwan Shinawi, Ina Amarillo, Louis P Dehner, Katherine Semenkovich, Ana María Arbeláez
We report a detailed phenotypic, cytogenetic, and molecular characterization of a patient diagnosed prenatally with Turner syndrome (TS). In addition to having typical TS clinical characteristics such as a webbed neck, high arched palate, and coarctation of the aorta, the patient had features less frequently seen in TS, including recurrent parathyroid adenomas, growth along the 75th-90th centiles on the TS height curve despite a minimal treatment with growth hormone, behavioral problems, and evidence of gonadal dysgenesis with testicular-like structures, such as seminiferous tubules lined by Sertoli cells and a contiguous nodule of Leydig cells...
May 9, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29737315/applicability-of-transoral-endoscopic-parathyroidectomy-through-vestibular-route-for-primary-sporadic-hyperparathyroidism-a-south-indian-experience
#5
P R K Bhargav, M Sabaretnam, V Amar, N Vimala Devi
Introduction: Primary hyperparathyroidism is one of the most common endocrine disorders requiring surgical parathyroidectomy for its definitive treatment. Surgical exploration is traditionally performed through conventional open neck approach. A wide range of minimal access and minimally invasive endoscopic techniques (gas less and with gas) have been attempted in the past two decades. In this context, we evaluated the feasibility and safety of an innovative transoral endoscopic parathyroidectomy (EP) technique, which represents a paradigm shift in transluminal endocrine surgery...
May 4, 2018: Journal of Minimal Access Surgery
https://www.readbyqxmd.com/read/29736849/diagnostic-accuracy-of-3t-magnetic-resonance-imaging-in-the-preoperative-localisation-of-parathyroid-adenomas-comparison-with-ultrasound-and-99mtc-sestamibi-scans
#6
Renato Argirò, Daniele Diacinti, Beatrice Sacconi, Angelo Iannarelli, Davide Diacinti, Cristiana Cipriani, Daniela Pisani, Elisabetta Romagnoli, Marco Biffoni, Cira Di Gioia, Jessica Pepe, Mario Bezzi, Claudio Letizia, Salvatore Minisola, Carlo Catalano
OBJECTIVES: To evaluate the diagnostic performance of 3TMRI in comparison with ultrasound (US) and 99mTc-sestamibi scan for presurgical localisation of parathyroid adenomas (PTAs) in patients with primary hyperparathyroidism (PHPT). METHODS: Fifty-seven patients affected by PHPT were prospectively enrolled and underwent US, 99mTc-sestamibi and 3TMRI. T2-weighted and post-contrast T1-weighted Iterative decomposition of water and fat with Echo Asymmetry and Least squares estimation (IDEAL) sequences were acquired...
May 7, 2018: European Radiology
https://www.readbyqxmd.com/read/29735505/osteitis-fibrosa-cystica-masquerading-as-bone-neoplasm
#7
Vishnu Vardhan Garla, Israh Akhtar, Sohail Salim, Angela Subauste
A 50-year-old female patient with no significant medical history presented with left knee pain. Radiographs of the knee showed a circumferential swelling of the distal femur suggestive of neoplasia. Further evaluation revealed multiple lesions in the left iliac bone and proximal femur. Biopsy was suggestive of a reparative granuloma or an aneurysmal bone cyst. Laboratory assessment showed hypercalcaemia and elevated parathyroid hormone consistent with severe primary hyperparathyroidism. Osseous survey was significant for salt and pepper appearance of the skull...
May 7, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29730179/complementary-role-of-parathormone-washout-test-to-99m-tc-mibi-parathyroid-scintigraphy-and-histopathologic-analysis-of-cell-types-in-parathyroid-adenomas
#8
Semra Ince, Ozdes Emer, Salih Deveci, Kursat Okuyucu, Engin Alagoz, Huseyin San, Aslı Ayan, Ozgur Karacalioglu, Cem Haymana, Bengul Gunalp, Nuri Arslan
OBJECTIVE: Parathyroid scintigraphy (PS) can be negative or equivocal (N/E) in a considerable number of cases with highly suspicious clinical findings and biochemical results for parathyroid adenoma (PA). The aims of this study were to investigate the complementary role of parathormone washout test (PWT) to PS in patients with primary hyperparathyroidism (PHPT) and evaluate histopathologic aspects of PAs in comparison with PS results. MATERIAL AND METHODS: Thirty-eight patients with PHPT referred for PS were included in the study...
May 2, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29724878/the-aberrantly-expressed-mir-372-partly-impairs-sensitivity-to-apoptosis-in-parathyroid-tumor-cells
#9
Chiara Verdelli, Irene Forno, Annamaria Morotti, Pasquale Creo, Vito Guarnieri, Alfredo Scillitani, Filomena Cetani, Leonardo Vicentini, Gianni Balza, Edoardo Beretta, Stefano Ferrero, Valentina Alessandra Vaira, Sabrina Corbetta
Parathyroid tumors deregulate microRNAs belonging to the two clusters on the chromosome 19, the C19MC and miR-371-373 clusters. Here, we report that the embryonic miR-372 is aberrantly expressed in half of parathyroid adenomas, (PAds) in most of atypical adenomas and carcinomas (n=15). Through in situ hybridization we identified that miR-372-positive parathyroid tumor cells were scattered throughout the tumor parenchyma. In PAds-derived cells, ectopic miR-372 inhibited the expression of its targets CDKN1A/p21 and LATS2 at both mRNA and protein levels...
May 3, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29724805/recognizing-pinhole-parallax-error-for-accurate-localization-of-thyroid-and-parathyroid-pathology
#10
Ismet Sarikaya, Zaina Al-Banna, Ali Baqer
Parallax error is a pitfall of pinhole scintigraphy which causes mislocalization of the objects. It is important to notice this error on pinhole thyroid and parathyroid scintigraphy and obtain additional images with parallel-hole collimator to accurately determine the upper and lower margins of large goiter and nodules and location of the ectopic thyroid tissue and parathyroid adenomas. In this teaching case report we wanted to revisit pinhole parallax error, present pinhole and SPECT/CT images of a case with large hyperactive thyroid nodule and review the literature and potential solutions to this important problem...
May 3, 2018: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/29681636/parkinsonism-as-presenting-symptom-of-primary-hyperparathyroidism-improvement-after-surgery
#11
Delia Luján-Martínez, Ángela Sánchez-Cifuentes, Emilio Peña-Ros, Antonio Albarracín-Marín-Blázquez, Mari Fe Candel-Arenas
Introduction: Hypercalcemia can cause different neurological disorders, depending on the calcium level. We report an exceptional case of primary hyperparathyroidism presenting as neurological alteration and it has favourable outcome after parathyroidectomy. Case report: A 74-year-old woman presented with progressive cognitive deterioration and impaired motor function. The complementary tests showed hypercalcemia due to a parathyroid adenoma. Parathyroidectomy was performed with symptomatic improvement...
2018: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/29680989/challenging-pre-surgical-localization-of-hyperfunctioning-parathyroid-glands-in-primary-hyperparathyroidism-the-added-value-of-18-f-fluorocholine-pet-ct
#12
Serena Grimaldi, Jacques Young, Peter Kamenicky, Dana Hartl, Marie Terroir, Sophie Leboulleux, Amandine Berdelou, Julien Hadoux, Segolene Hescot, Hervé Remy, Eric Baudin, Martin Schlumberger, Désirée Deandreis
PURPOSE: To evaluate the added value of 18 F-Fluorocholine (18 F-FCH) PET/CT in presurgical imaging of patients with primary hyperparathyroidism (HPT) and challenging localization of the hyper-functioning parathyroid glands. METHODS: We included 27 consecutive patients with primary HPT (19 F; median age: 58 years), with either (i) non-conclusive pre-surgical localization with 99 mTc-sestaMIBI scintigraphy and neck ultrasonography (US), (ii) recurrence of previously operated HPT, or (iii) familiar HPT with a suspicion of multiple gland disease...
April 22, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29678483/maxillofacial-brown-tumours-series-of-5-cases
#13
F Antin, D Bakhos, F Jegoux, M Merkouza, L Laccourreye
OBJECTIVES: Brown tumours are benign bone tumours secondary to hyperparathyroidism. The authors describe the various clinical features, diagnostic methods and treatment modalities for maxillofacial brown tumours. MATERIAL AND METHODS: This multicentre retrospective study comprised 5 patients (four women and one man, between the ages of 29 and 70 years) with one or several maxillofacial brown tumours observed over a 16-year period from January 2000 to December 2016...
April 17, 2018: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/29662599/-spontaneous-simultaneous-bilateral-rupture-of-the-quadriceps-tendon-in-patients-with-parathyroid-adenoma-case-report-and-literature-review
#14
Amour Espoir Mokoko-Louckou, Badarou Chaibou, Ismail Abdouli, Kevin Parfait Bienvenu Bouhelo-Pam, Mohammed El Idrissi, Mohammed Shimi, Abdelhalim El Ibrahimi, Abdelmajid El Mrini
Spontaneous as well as bilateral and simultaneous rupture of the quadriceps tendon is rare. We report the case of a 53-year old patient followed up for parathyroid adenoma complicated by renal failure, admitted for spontaneous bilateral rupture of the two quadriceps tendons. He underwent surgical repair allowing him to maintain his autonomy.
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29662564/dual-pathologies-of-parathyroid-adenoma-and-papillary-thyroid-cancer-on-fluorocholine-and-fluorodeoxyglucose-pet-ct
#15
N T K Thanseer, Sanjay Kumar Bhadada, Ashwani Sood, Ashwin Singh Parihar, Divya Dahiya, Priyanka Singh, Rajender Kumar Basher, Ashim Das, Bhagwant R Mittal
18 F-Fluorocholine (FCH) PET/CT is evolving as a functional imaging modality for the preoperative imaging of abnormal parathyroid tissue(s) helping to localize eutopic and ectopic parathyroid tissue and limit the extent of surgery. FCH PET/CT may show incidental uptake in various thyroid lesions necessitating further evaluation, whereas the role of 18 F-fluorodeoxyglucose (FDG) PET/CT in the detection of incidental thyroid nodules is well documented. The case of a middle-aged woman with dual pathology of parathyroid adenoma and papillary thyroid cancer detected on FCH and FDG PET/CT is presented...
April 2018: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29662267/decrement-in-bone-mineral-density-after-parathyroidectomy-in-a-pediatric-patient-with-primary-hyperparathyroidism
#16
Hidechika Morimoto, Hisakazu Nakajima, Jun Mori, Shota Fukuhara, Keiichi Shigehara, Shinsuke Adachi, Hajime Hosoi
Primary hyperparathyroidism (PHT) causes increased bone turnover, leading to reduction in bone mineral density (BMD). Parathyroidectomy is a definitive therapy and improves BMD in adult patients with PHT. However, there are no reports regarding alterations of BMD in pediatric or adolescent patients with PHT. Here, we report a case of a 13-yr-old boy with PHT who was referred to our institution for evaluation of hypercalcemia and hyperparathyroidism. Radiological investigation revealed an ectopic parathyroid adenoma below the right thyroid lobe...
2018: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29659895/identification-of-differential-transcriptional-patterns-in-primary-and-secondary-hyperparathyroidism
#17
Samira M Sadowski, Marc Pusztaszeri, Marie-Claude Brulhart-Meynet, Volodymyr Petrenko, Claudio De Vito, Jonathan Sobel, Céline Delucinge-Vivier, Electron Kebebew, Romano Regazzi, Jacques Philippe, Frédéric Triponez, Charna Dibner
Context: Hyperparathyroidism is associated with hypercalcemia and the excess of parathyroid hormone secretion. However, the alterations in molecular pattern of functional genes during parathyroid tumorigenesis have not been unraveled. We aimed at establishing transcriptional patterns of normal and pathological parathyroid glands (PG) in sporadic primary and secondary hyperparathyroidism (HPT1, 2). Objective: To evaluate dynamic alterations in molecular patterns as a function of the type of PG pathology, a comparative transcript analysis was conducted in subgroups of healthy samples, sporadic HPT1 adenoma and hyperplasia, and HPT2...
April 5, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29658374/hypercalcemic-crisis-in-third-trimenon-evaluating-the-optimal-treatment-strategy
#18
Julie Refardt, Patricia Farina, Irene Hoesli, Christian Meier
Hypercalcemia due to primary hyperparathyroidism during pregnancy is a rare condition and associated with increased morbidity and mortality for the mother and the unborn child. Whereas parathyroidectomy is favored during the second trimester, no clear recommendations exist for its management during the third trimenon. We here report the case of a 26-year-old woman in the 29th week of her first pregnancy, who was admitted to our clinic with hypertension, intra-uterine growth retardation and polyhydramnios. Severe hypercalcemia due to primary hyperparathyroidism was diagnosed (total calcium 3...
April 16, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29657879/primary-hyperparathyroidism-and-gougerot-disease
#19
Toumader Bouziane, Nadia Belmahi, Hanan El Ouahabi
Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by the overactivation of the parathyroid glands due to the autonomous production of the parathyroid hormone (PTH). The resultant hypercalcemia leads to a myriad of symptoms. Here we report the case of a 54-year-old female with a previous diagnosis of Gougerot disease, in whom clinical (diffuse bone pain, asthenia polydipsia, and polyuria) and laboratory features (calcium level, 3.1 mmol/L; phosphate level, 0.55 mmol/L; alkaline phosphatase level, 70 U/L; and intact PTH level, 1028...
March 2018: European Journal of Rheumatology
https://www.readbyqxmd.com/read/29644341/uptake-of-99m-tc-mibi-by-sclerosing-pneumocytoma-raising-a-false-suspicion-of-metastasis-from-medullary-thyroid-carcinoma
#20
Georgios E Papadakis, Flavian Tabotta, Igor Levotanec, Michel Gonzalez, John O Prior, Stefano La Rosa, Gerasimos P Sykiotis
Technetium-99m methoxy isobutyl isonitrile (99m Tc-MIBI; sestamibi) single-photon emission computed tomography (SPECT)/computed tomography (CT) performed for preoperative localization of parathyroid adenomas or for other indications can reveal incidentalomas. Interpretation of such findings can be challenging, particularly when thyroid or other endocrine tumors are also present. Preoperative staging of a 59-year-old female patient with medullary thyroid carcinoma (MTC) showing moderate hypermetabolism on 18 F-fluorodeoxyglucose positron emission tomography/CT also detected a slightly hypermetabolic pulmonary nodule (standardized uptake value normalized by body weight max = 2...
April 1, 2018: Journal of the Endocrine Society
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