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Parathyroid adenoma

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https://www.readbyqxmd.com/read/28728949/diffuse-hematoma-caused-by-spontaneous-rupture-of-a-parathyroid-adenoma-a-case-report
#1
Lifeng An, Tiefeng Ji, Lin Li
No abstract text is available yet for this article.
July 7, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28721219/two-rare-manifestations-of-primary-hyperparathyroidism-paralysis-and-peptic-ulcer-bleeding
#2
Maryam Heidarpour, Mehdi Karami, Pegah Hedayat, Ashraf Aminorroaya
Primary hyperparathyroidism revealed by thoracic spine brown tumor and peptic ulcer bleeding is rare. We presented a case of 33-year-old male patient who was admitted with paraplegia. Thoracic spine magnetic resonance imaging (MRI) showed extradural lesion at T4 level. He underwent surgical decompression in T4. According to histopathologic finding and elevated serum parathormone (PTH) and hypercalcemia (total serum calcium 12.1 mg/dL), the diagnosis of brown tumor was down. Ultrasonography of his neck showed a well-defined lesion of 26 × 14 × 6 mm...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28705526/utility-of-single-phase-computed-tomography-in-identifying-parathyroid-adenomas-a-feasibility-study
#3
Ethan Silver, Nader Sadeghi, Stanley Knoll, M Reza Taheri
OBJECTIVE: We tested the hypothesis that a single-phase neck computed tomography (CT) is not inferior to multiphase neck CT (MPNCT), ultrasound, or nuclear medicine sestamibi scan in identifying parathyroid adenomas (PAs). METHODS: A total of 29 patients who had an MPNCT for the evaluation of a PA were identified; 11 patients met the inclusion criteria. During the 30-second arterial phase CT (APNCT), a normalized Hounsfield unit of suspected PA was compared to Hounsfield unit of a normal-appearing level I and a level II lymph node...
May 17, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28693130/novel-association-of-men1-gene-mutations-with-parathyroid-carcinoma
#4
Luigia Cinque, Angelo Sparaneo, Filomena Cetani, Michelina Coco, Celeste Clemente, Massimiliano Chetta, Teresa Balsamo, Claudia Battista, Eliana Sanpaolo, Elena Pardi, Leonardo D'Agruma, Claudio Marcocci, Evaristo Maiello, Geoffrey N Hendy, David E C Cole, Alfredo Scillitani, Vito Guarnieri
Inactivating mutations of the multiple endocrine neoplasia 1 (MEN1) gene cause MEN1 syndrome, characterized by primary hyperparathyroidism (pHPT), and parathyroid and gastro-entero-pancreatic pituitary tumors. At present, only 14 cases of malignant parathyroid tumor have been associated with the syndrome, with 6 cases carrying an inactivating mutation of the MEN1 gene. The present study presents the case of a 48-year-old female who presented with multigland pHPT and multiple pancreatic lesions. The patient underwent surgery several times for the excision of parathyroid hyperplasia, carcinoma and adenoma...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28683236/the-results-of-parathyroid-hormone-assay-in-parathyroid-aspirates-in-preoperative-localization-of-parathyroid-adenomas-for-focused-parathyroidectomy-in-patients-with-negative-or-suspicious-technet%C3%A4-um-99-msestam%C3%A4-b%C3%A4-scans
#5
Aysenur Ozderya, Sule Temizkan, Kenan Cetin, Sule Ozugur, Aylin Ege Gul, Kadriye Aydin
OBJECTIVE: This study aims to evaluate the results of parathyroid hormone (PTH) assay in parathyroid aspirates to determine uniglandular disease by an endocrinologist-performed ultrasound in patients with discordant or negative technetium ((99m)Tc) sestamibi scans and to evaluate whether this pocedure increases the number of focused parathyroidectomy (FP). METHODS: We analyzed the data of 65 patients who underwent an endocrinologist-performed ultrasound (US) guided parathyroid fine needle aspiration (FNA) with PTH wash-out, retrospectively...
July 6, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28680226/typifying-the-atypical-parathyroid-adenoma
#6
Panchangam Ramakanth Bhargav
No abstract text is available yet for this article.
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28680214/ectopic-parathyroid-incidentaloma-on-tc99m-sestamibi-myocardial-perfusion-imaging
#7
Rola Aatif Hasan Hussain, Ammar Mohammed Saeed Ali, K Manivannan, S K Chirala
Parathyroid incidentalomas are generally discovered during thyroid surgery.([1]) In the present case, the ectopic parathyroid adenoma was discovered as an incidentaloma in a clinical setting, during the course of clinical evaluation of atypical chest pain by gastroenterology and cardiology.
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28680200/radio-guided-minimally-invasive-parathyroidectomy-a-descriptive-report-of-the-experience-from-tertiary-center-in-bangalore
#8
Bhushan Vidya, Shubhra Chauhan, Naveen Hedne Chandrasekhar, H V Sunil, Vijay Pillai, Vivek Shetty, R L Vijayaraghavan, Moni Abraham Kuriakose, Subramanian Kannan
OVERVIEW: Minimally invasive parathyroidectomy (MIP) is an accepted surgical procedure for parathyroid adenomas. In the patients with parathyroid adenoma localized by dual phase (99m)Tc-Sestamibi scan, a focused approach utilizing the gamma probe intra-operatively helps in ensuring complete resection and avoiding exploration of the other parathyroid glands. OBJECTIVE: The aim of the study was to evaluate the performance of radio-guided MIP for parathyroid adenomas detected by dual phase (99m)Tc-MIBI preoperatively, without intra-operative parathyroid hormone (ioPTH) monitoring for patients who had evidence of single-gland disease...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28671157/primary-hyperparathyroidism-in-pregnancy
#9
Meryem Rchachi, Hanan El Ouahabi, Saïd Boujraf, Farida Ajdi
Primary hyperparathyroidism (PHT) is a frequent and asymptomatic pathology in 80% of patients, and a parathyroidal adenoma is found in the most case. However, rare cases might occur during pregnancy; and the literature reported up to 200 cases. We report three cases of PHT that occurred during the second and last third trimesters of pregnancy stage in patients aged 26, 42 and 32-year-old. Despite diagnosis limitations, since scintigraphy is prohibited in pregnancy, the patients were managed conservatively with good prognosis for both mothers and babies...
July 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28667008/a-case-of-acute-confusion-cushing-s-syndrome-presenting-with-primary-hyperparathyroidism
#10
Esmee Irvine, Yew Wen Yap, Tej Purewal, Esmee Irvine
Cushing's syndrome is a rare disease. Cushing's syndrome presenting as acute psychosis is an exceptional occurrence. We present the case of a 37-year-old woman who was admitted with acute confusion associated with mild hypercalcaemia and was subsequently diagnosed with parathyroid and adrenal adenomas. Our hospital sees approximately 6000 endocrine patients per year, with an incidence of around four Cushing's cases annually. This is the first such case to occur in our hospital and one of few described in the literature...
June 30, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28658791/ectopic-parathyroid-adenoma-presenting-as-a-mediastinal-mass
#11
Aneesha Vaidya, Mangala Gouri, H M Sudha, Vijaya Mysorekar, Avinash Balekudura
A parathyroid adenoma present in an ectopic site, in the anterior mediastinum, is a rare cause of persistent hyperparathyroidism. Though its occurrence in the mediastinum is unusual, existence has been noted in literature for more than a century. We describe a case of a 35-year-old male presenting with complaints of pain abdomen, clinically diagnosed as acute necrotizing pancreatitis, with raised serum calcium. Patient received symptomatic treatment for the pancreatitis which subsided. However, high levels of serum calcium persisted...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28656592/percentage-arterial-enhancement-an-objective-index-for-accurate-identification-of-parathyroid-adenoma-hyperplasia-in-primary-hyperparathyroidism
#12
Manjunath Goroshi, Anurag R Lila, Swati S Jadhav, Sushil Sonawane, Priya Hira, Shettepppa Goroshi, Mahadev N Garle, Abhay Dalvi, Pragati Sathe, Tushar R Bandgar, Nalini S Shah
BACKGROUND: Radiation exposure to neck by 4DCT is relatively high and limits its use as a first line investigation in evaluation of PHPT. Radiation exposure can be reduced by restricting the number of CT phases. Our aim was to study the performance of 4DCT in cohort of surgery-naïve primary hyperparathyroidism(PHPT) patients, and to evaluate percentage enhancement as an objective radiological index to discriminate parathyroid lesions(adenoma/hyperplasia) from thyroid tissue and lymph nodes...
June 28, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28648877/a-rare-presentation-a-case-report-of-osseous-metaplasia-and-mature-bone-formation-in-a-follicular-adenoma-of-the-thyroid
#13
Nadia Aurora, Insia Hashmi, Subhasis Misra, Nail Aydin
INTRODUCTION: Cases of multinodular goiter, thyroid hyperplasia, follicular adenoma, papillary thyroid carcinoma, and anaplastic thyroid carcinoma have been reported with histopathologic findings of osseous metaplasia (OM), bone marrow metaplasia (BMM), ectopic bone formation (EBF), ossification, and extramedullary hematopoiesis (EMH). To date no report of a follicular adenoma with OM and mature EBF in the absence of EMH has been reported in the English language. PRESENTATION OF CASE: 63-year-old woman with an incidental finding of thyroid nodule unable to be biopsied...
June 17, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28637440/acute-airway-compromise-due-to-parathyroid-tumour-apoplexy-an-exceptionally-rare-and-potentially-life-threatening-presentation
#14
Aoife Garrahy, David Hogan, James Paul O'Neill, Amar Agha
BACKGROUND: Spontaneous haemorrhage into a parathyroid adenoma is a rare and potentially life-threatening presentation. CASE PRESENTATION: We report the case of a 45 year old female recently diagnosed with primary hyperparathyroidism who presented with chest discomfort and acute airway compromise due to spontaneous extracapsular haemorrhage into a parathyroid adenoma. Computed tomography (CT) imaging showed a hypopharyngeal haematoma extending 10 cm into the superior mediastinum...
June 21, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28636744/parathyroid-carcinoma-in-a-patient-with-three-prior-parathyroid-adenomas
#15
Michael Goldenberg, Henry Crist, Darrin V Bann
No abstract text is available yet for this article.
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28614134/value-of-99mtc-mibi-spect-ct-parathyroid-imaging-and-ultrasonography-for-concomitant-thyroid-carcinoma
#16
Rui Guo, Jiqiu Wang, Min Zhang, Miao Zhang, Hongping Meng, Yifan Zhang, Biao Li
PURPOSE: We aimed to assess the frequency of carcinoma in cases with suspected parathyroid adenoma and test the value of Tc-methoxyisobutylisonitrile (Tc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) parathyroid imaging and neck ultrasonography in detecting concomitant thyroid carcinoma. PATIENTS AND METHODS: We enrolled 741 patients with clinically suspected parathyroid adenoma who underwent Tc-MIBI planer scans and SPECT/CT of the skull base, neck, and thorax; patients also underwent ultrasonography within 1 month before SPECT/CT...
August 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28609842/specifying-the-molecular-pattern-of-sporadic-parathyroid-tumorigenesis-the-y282d-variant-of-the-gcm2-gene
#17
Elena Marchiori, Maria Rosa Pelizzo, Monika Herten, Danyelle M Townsend, Domenico Rubello, Isabella Merante Boschin
Sporadic carcinoma of the parathyroid glands is a rare malignant neoplasia. The GCM2 gene encodes a transcription factor that is crucial to embryonic parathyroid development. The Y282D variant of GCM2 exhibits increased transcriptional activity, and the presence of this variant is significantly associated with a higher prevalence of primitive hyperparathyroidism. The present study investigated the prevalence of the Y282D variant of the GCM2 gene and its association with clinical parameters in patients with a definitive histological diagnosis of sporadic parathyroid carcinoma (SPC) or atypical adenoma (AA)...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28600574/promoter-hypermethylation-inactivates-cdkn2a-cdkn2b-and-rassf1a-genes-in-sporadic-parathyroid-adenomas
#18
Ashutosh Kumar Arya, Sanjay Kumar Bhadada, Priyanka Singh, Naresh Sachdeva, Uma Nahar Saikia, Divya Dahiya, Arunanshu Behera, Anil Bhansali, Sudhaker D Rao
Cyclin D1, a G1-S phase regulator, is upregulated in parathyroid adenomas. Since cyclin-dependent kinase (CDK) inhibitors, CDKN2A and CDKN2B, and RASSF1A (Ras-association domain family 1, isoform A) are involved in G1-S phase arrest and act as potential tumor suppressor genes, we aimed to study potential methylation-mediated inactivation of these genes in parathyroid adenomas. Gene expressions of cyclin D1 (CCND1) and regulatory molecules (CDKN2A, CDKN2B and RASSF1A) was analysed in parathyroid adenoma tissues (n = 30)...
June 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28579010/-maxillary-buccal-and-dental-expressions-of-hyperparathyroidisms
#19
Jean-Louis Wémeau, Catherine Cardot-Bauters
States of chronic parathyroid hypersecretion, related to a primitive parathyroid abnormality (adenoma, hyperplasia), or to a cause of chronic calcipenia (renal failure, vitamin D deficiency…) have a major impact on bone remodeling, alveolodental structures. Thinning of the lamina dura, maxillary or mandibular brown tumors, giant cell epulis are the most emblematic signs of the primary hyperparathyroidism. Other expressions are related to genetic factors such as fibrous tumors of the jaw in conjunction with mutations in the gene coding for parafibromin...
June 1, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28571792/papillary-carcinoma-of-the-thyroid-in-patients-with-primary-hyperparathyroidism-is-there-a-link
#20
M Beebeejaun, E Chinnasamy, P Wilson, A Sharma, N Beharry, G Bano
Primary hyperparathyroidism (PHPT) is present in up to 0.1% of the general population. The incidence is higher in women and increases with age. The majority of the cases is asymptomatic and up to 85% are due to single gland adenoma. Parathyroidectomy is the treatment of choice after localization of the hyperactive gland. Papillary Thyroid Carcinoma (PTC) is the most common cancer of the thyroid and constitutes more than 70% of thyroid malignancies. PTC can present as a single nodule or can be Multifocal. The incidence is higher in women...
June 2017: Medical Hypotheses
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