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Parathyroid adenoma

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https://www.readbyqxmd.com/read/28033216/incremental-value-of-18f-fluorocholine-pet-ct-in-the-localization-of-double-parathyroid-adenomas
#1
Paul Lalire, Sang Ly, Sophie Deguelte, Martine Patey, David Morland
A 73-year-old man displaying primary hyperparathyroidism with severe hypercalcemia (Ca: 4.1 mmol/l, PTH > 600 pmol/l) was referred for preoperative localization of a parathyroid adenoma. Tc-pertechnetate and Tc-sestaMIBI dual tracer scintigraphy displayed a mild focal uptake in the projection of the right thyroid lobe with negative ultrasonography. F-Fluorocholine PET/CT was quickly performed considering this discrepancy and not only confirmed the scintigraphic findings but also revealed a second contralateral focus of increased uptake, both later confirmed by operative consideration (the two other parathyroid glands are considered normal by the surgeon), pathology, and intraoperative parathyroid hormone assessment...
December 28, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28017299/is-intraoperative-parathyroid-hormone-monitoring-necessary-for-primary-hyperparathyroidism-with-concordant-preoperative-imaging
#2
Iuliana D Bobanga, Christopher R McHenry
BACKGROUND: The purpose of this study was to determine if intraoperative parathyroid hormone (PTH) monitoring is necessary in patients with concordant ultrasound and sestamibi imaging. METHODS: Clinical factors, intraoperative findings and outcome were correlated with imaging results in patients with primary hyperparathyroidism who underwent parathyroidectomy with concordant ultrasound and sestamibi imaging. RESULTS: There were 127 patients with primary hyperparathyroidism and concordant imaging who underwent parathyroidectomy...
November 23, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/28003924/intrathyroidal-clear-cell-tumor-of-parathyroid-origin-with-review-of-literature
#3
Daniela Pirela, Daniela Treitl, Siba El Hussein, Robert Poppiti, Thomas Mesko, Alex Manzano
Water-clear cell adenoma (WCCA) of the parathyroid gland is an exceedingly rare neoplasm. To date, 17 cases have been reported in the literature, with only one of them being intrathyroidal. Here we report a case of a 34-year-old woman who presented for evaluation of a goiter and was found to have a thyroid nodule and abnormal thyroid function tests (TFT). Fine needle aspiration biopsy of the nodule revealed thyroid follicular cells without atypia and subsequent Afirma® Gene Expression Classifier (GEC) testing results were suspicious for malignancy...
2016: Case Reports in Pathology
https://www.readbyqxmd.com/read/27987183/a-gamma-distribution-convolution-model-of-99m-tc-mibi-thyroid-time-activity-curves
#4
Carl A Wesolowski, Surajith N Wanasundara, Michal J Wesolowski, Belkis Erbas, Paul S Babyn
BACKGROUND: The convolution approach to thyroid time-activity curve (TAC) data fitting with a gamma distribution convolution (GDC) TAC model following bolus intravenous injection is presented and applied to (99m)Tc-MIBI data. The GDC model is a convolution of two gamma distribution functions that simultaneously models the distribution and washout kinetics of the radiotracer. The GDC model was fitted to thyroid region of interest (ROI) TAC data from 1 min per frame (99m)Tc-MIBI image series for 90 min; GDC models were generated for three patients having left and right thyroid lobe and total thyroid ROIs, and were contrasted with washout-only models, i...
December 2016: EJNMMI Physics
https://www.readbyqxmd.com/read/27957351/the-biochemical-profile-of-familial-hypocalciuric-hypercalcemia-and-primary-hyperparathyroidism-during-pregnancy-and-lactation-two-case-reports-and-review-of-the-literature
#5
S A Ghaznavi, N M A Saad, L E Donovan
Background. Primary hyperparathyroidism (PHPT) and Familial Hypocalciuric Hypercalcemia (FHH) result in different maternal and fetal complications in pregnancy. Calcium to creatinine clearance ratio (CCCR) is commonly used to help distinguish these two conditions. Physiological changes in calcium handling during pregnancy and lactation can alter CCCR, making it a less useful tool to distinguish PHPT from FHH. Cases. A 25-year-old female presented with hypercalcemia and an inappropriately normal PTH. Her CCCR was 0...
2016: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/27941372/early-and-delayed-18f-fch-pet-ct-imaging-in-parathyroid-adenomas
#6
Cecilia Vellani, Marina Hodolič, Spyridon Chytiris, Giuseppe Trifirò, Domenico Rubello, Patrick M Colletti
Preoperative localization with Tc-sestaMIBI or ultrasound is a common prerequisite for successful minimally invasive parathyroid adenoma (PA) surgery. SPECT/CT with Tc-sestaMIBI and PET/CT with F-FCH offer the possibility of attenuation correction and coregistration of functional and anatomical images providing more accurate PA localization. F-FCH PET/CT is used predominantly in patients with prostate cancer and is under investigation in PA. We report the case of a 43-year-old man with early FCH uptake in a cystic PA with delayed washout at 60 minutes...
December 9, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27941175/a-case-of-hypercalcaemic-crisis-secondary-to-coexistence-of-primary-hyperparathyroidism-and-graves-disease
#7
S Baldane, S H Ipekci, R Evcen, G K Gedik, I Guler, L Kebapcilar
A 46 year-old female patient presented to the hospital with ongoing and progressively increasing fatigue, severe nausea and vomiting, loss of appetite, constipation, palpitations and somnolence. Laboratory evaluation revealed a severe hypercalcaemia and overt hyperthyroidism. She was diagnosed with primary hyperparathyroidism accompanied by Graves' disease. The patient underwent total thyroidectomy and right inferior parathyroid gland adenoma excision on the 24th day of her admission to the hospital after calcium levels and free thyroid hormone levels were brought to normal ranges...
October 1, 2016: Endocrine Regulations
https://www.readbyqxmd.com/read/27939023/ultrasound-based-focused-neck-exploration-for-primary-hyperparathyroidism
#8
Stephen J Bradley, Kathleen F Knodle
OBJECTIVE: We review our experience with focused neck exploration (FNE) based on ultrasound (USN) alone, in patients with primary hyperparathyroidism (PHP) and negative sestamibi scans (SES). METHODS: 124 patients with PHP were evaluated for FNE and studied with SES and USN. 53 patients (43%) had a negative SES. 49 of those patients (92%) were selected for FNE based on USN criteria of a single abnormal gland, .5 cm or greater, as determined by an experienced surgeon-sonographer...
November 19, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27933172/brown-tumor-of-the-jaw-after-pregnancy-and-lactation-in-a-men1-patient
#9
Anna Casteràs, Lídia Darder, Carles Zafon, Juan Antonio Hueto, Margarita Alberola, Enric Caubet, Jordi Mesa
: Skeletal manifestations of primary hyperparathyroidism (pHPT) include brown tumors (BT), which are osteoclastic focal lesions often localized in the jaws. Brown tumors are a rare manifestation of pHTP in Europe and USA; however, they are frequent in developing countries, probably related to vitamin D deficiency and longer duration and severity of disease. In the majority of cases, the removal of the parathyroid adenoma is enough for the bone to remineralize, but other cases require surgery...
2016: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/27928436/parathyroidectomy-is-vitamin-d-a-player-for-a-good-outcome
#10
REVIEW
Carsote M, Paduraru Dn, Nica Ae, Valea A
Background: The field of parathyroidectomy (PTx) is complex and brings together many specialists. Even if the surgical approaches changed from classical to minimally invasive PTx, a good outcome is correlated with an adequate localization before and during PTx, while blood assays, such as parathormone (PTH) or 25-hydroxyvitamin D, become useful additional markers. Aim. Specific aspects related to parathyroidectomy and vitamins D (VD) were introduced. Material and Method. The article represents a PubMed-based narrative review...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27913036/pattern-of-calcium-and-parathyroid-hormone-normalization-at-12-months-follow-up-after-parathyroid-operation
#11
Olga A Lavryk, Allan E Siperstein
BACKGROUND: At 12 months after a parathyroid operation, we expect cured patients to have biochemical profiles similar to those of healthy individuals. The aim of the current study was to compare the biochemical characteristics patients at 12 months after parathyroidectomy for primary sporadic hyperparathyroidism with those of healthy controls. METHODS: A total of 547 patients who underwent parathyroid neck operation for primary sporadic hyperparathyroidism from 2000-2014 were analyzed...
November 29, 2016: Surgery
https://www.readbyqxmd.com/read/27904855/multiple-endocrine-neoplasia-type-1-with-anterior-mediastinal-parathyroid-adenoma-successful-localization-using-tc-99m-sestamibi-spect-ct
#12
Hye Lim Park, Ie Ryung Yoo, Sung Hoon Kim, Sohee Lee
The most common manifestation of multiple endocrine neoplasia type 1 (MEN1) is hyperparathyroidism. Treatment of hyperparathyroidism in MEN patients is surgical removal of the parathyroid glands, however ectopic parathyroid gland is challenging for treatment. A 51-year-old female, the eldest of 3 MEN1 sisters, had hyperparathyroidism with ectopic parathyroid adenoma in the mediastinal para-aortic region, which was detected by technetium-99m (Tc-99m) sestamibi scintigraphy and single-photon emission computed tomography/computed tomography (SPECT/CT)...
December 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27901181/evaluation-of-preoperative-ultrasonographic-and-biochemical-features-of-patients-with-aggressive-parathyroid-disease-is-there-a-reliable-predictive-marker
#13
Bekir Cakir, Sefika Burcak Polat, Mehmet Kilic, Didem Ozdemir, Cevdet Aydin, Nuran Süngü, Reyhan Ersoy
Objective: Parathyroid cancer (PC) represents < 1% of cases of PHPT. Tumors demonstrating atypical histopathologic features and don't fulfill criteria for carcinoma are classified as atypical adenomas (APA). The purpose of this study was to determine a biochemical or ultrasonographic feature that can predict aggressive disease requiring more extensive surgery and closer follow-up. Subjects and methods: Twenty eight patients operated for PHPT and diagnosed with atypical adenoma (23 patients) or carcinoma (5 patients) were enrolled in this study...
November 2016: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27900863/-symptomatic-and-asymptomatic-primary-hyperparathyroidism-in-outpatient-care-current-issues
#14
Helena Šiprová, Miroslav Souček, Zdeněk Fryšák, Květoslav Šipr
OBJECTIVE: To assess the diagnostic and therapeutic options in the care of patients with primary hyperparathyreosis in outpatient practice.Cohort and methods: The study included all the patients with primary hyperparathyroidism treated at the 2nd Internal Medicine Department, Masaryk University and the University Hospital of St. Anne in Brno in the period from Jan 1, 2008 to Dec 31, 2013. The sample consisted of 218 patients, including 41 men and 177 women. Patients with secondary hyperparathyroidism, especially patients with underlying hypovitaminosis D, renal insufficiency and those taking medications with possible effects on parathyroid hormone levels, have not been included in the study...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27872158/filamin-a-is-reduced-and-contributes-to-the-casr-sensitivity-in-human-parathyroid-tumors
#15
Alessandra Mingione, Chiara Verdelli, Stefano Ferrero, Valentina Vaira, Vito Guarnieri, Alfredo Scillitani, Leonardo Vicentini, Gianni Balza, Edoardo Beretta, Annalisa Terranegra, Giuseppe Vezzoli, Laura Soldati, Sabrina Corbetta
Parathyroid tumors display reduced sensitivity to extracellular calcium ([Ca2+]o). [Ca2+]o activates calcium-sensing receptor (CASR), which interacts with the scaffold protein filamin A (FLNA). The study aimed to investigate: 1) the FLNA expression in human parathyroid tumors, 2) its effects on the CASR mRNA and protein expression, and 3) on ERK signaling activation, 4) the effect of the carboxy-terminal CASR variants and 5) of the treatment with the CASR agonist R568 on FLNA-mediated ERK phosphorylation in HEK293 cells...
November 21, 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27867896/synchronous-parathyroid-adenoma-and-papillary-thyroid-cancer-detected-on-99m-tc-sestamibi-scintigraphy
#16
Sameer Kamalakar Taywade, Nishikant A Damle, Madhavi Tripathi, Shipra Agarwal, Sameer Aggarwal
No abstract text is available yet for this article.
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27863779/how-long-should-we-follow-patients-after-apparently-curative-parathyroidectomy
#17
Irene Lou, Courtney Balentine, Samuel Clarkson, David F Schneider, Rebecca S Sippel, Herbert Chen
BACKGROUND: Little is known about the long-term recurrence risk for primary hyperparathyroidism after immediately "curative" parathyroidectomy. This study aimed to evaluate the risk of recurrent hyperparathyroidism in the 10 years after operation. METHOD: We retrospectively identified patients with sporadic primary hyperparathyroidism undergoing initial parathyroidectomy between November 1, 2000 and June 30, 2005. Recurrence was defined as serum calcium >10...
January 2017: Surgery
https://www.readbyqxmd.com/read/27857527/primary-hyperparathyroidism-jaw-tumor-syndrome-a-confusing-and-forgotten-diagnosis
#18
Doina Piciu, Andra Piciu, Elena Barbus, Claudiu Pestean, Maria Iulia Larg, Bogdan Fetica
BACKGROUND: Primary hyperparathyroidism is caused by the excessive growth of parathormone secretion, its consequence being hypercalcemia. The parathyroid adenoma is responsible for over half of primary hyperparathyroidism cases. The mandibular tumor can be the initial sign in the case of primary hyperparathyroidism. CASE PRESENTATION: We present the case of a 33 year old patient with history of a mandibular operated tumor, repetitive pathological fractures and hypercalcemia manifestations...
2016: Clujul Medical (1957)
https://www.readbyqxmd.com/read/27855990/-parathyroid-disease-the-full-spectrum-from-adenoma-to-carcinoma-report-of-3-cases
#19
Enrique Stoopen-Margain, Sofía Valanci-Aroesty, Leopoldo Castañeda-Martínez, Javier Baquera-Heredia, Juan Carlos Sainz-Hernández
BACKGROUND: Primary hyperparathyroidism is a disease characterised by the autonomous production of parathyroid hormone. The most common cause is an adenoma, followed by hyperplasia, and rarely carcinoma. CLINICAL CASES: Three cases are presented. The first case is associated with a brown tumour that was diagnosed as hyperplasia after study and surgery. The second case was related to pathological fractures, and a lower right adenoma 236 times bigger than a normal parathyroid was excised...
November 14, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27852814/spontaneous-proliferative-and-neoplastic-lesions-in-thyroid-and-parathyroid-glands-of-nondomestic-felids
#20
Jenny P Pope, James Steeil, Edward C Ramsay, Danielle Reel, Shelley J Newman
Based on microscopic and immunohistochemical characterization, we documented spontaneous proliferative and neoplastic lesions in the thyroid and parathyroid glands of nondomestic felids. Ten animals (4 leopards, 3 tigers, and 3 cougars), all with a previous diagnosis of thyroid neoplasia were identified from the University of Tennessee College of Veterinary Medicine database. The mean age of affected animals was 15.9 y. Twelve neoplasms were identified; 2 animals had 2 concurrent neoplasms. After immunohistochemical characterization using a panel of chromogranin A, thyroglobulin, and calcitonin, 7 of the former thyroid neoplasms were diagnosed as thyroid adenomas, 1 was diagnosed as a thyroid carcinoma, and 4 were diagnosed as parathyroid adenomas...
November 15, 2016: Journal of Veterinary Diagnostic Investigation
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