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https://www.readbyqxmd.com/read/28931105/neurofibromatosis-type-1-accompanied-by-craniofacial-pain-literature-review-and-descriptive-case
#1
Chunghwan Son, Ji Woon Park
Neurofibromatosis type 1 (NF-1) is a genetic disease with characteristic neurofibromas and bony dysplasia that manifest throughout the body, including the craniofacial region. NF-1 patients are known to frequently report chronic pain in areas below the head; however, the matter of pain in the craniofacial region in this patient group has not been handled intensively so far, and studies have mainly focused on headaches. This article comprehensively reviews the related literature and reports a case of an NF-1 patient whose chief complaint was headache and pain in the temporomandibular joint area...
September 20, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28929035/porcine-urinary-bladder-matrix-for-management-of-infected-radiation-mastectomy-wound
#2
Yana Puckett, Theophilus Pham, Shirley McReynolds, Catherine A Ronaghan
We present a case report on the successful healing of a Pseudomonas infection wound in a 52-year-old female with morbid obesity, noninsulin dependent diabetes mellitus and a history of tobacco use, who presented with Stage IIIA (T3, N2, Mo) infiltrating ductal carcinoma. The patient received neoadjuvant chemotherapy prior to her bilateral skin-sparing total mastectomies with right axillary sentinel lymphadenectomy. She also had staged reconstruction with temporary breast implants and plans for deep inferior epigastric perforator flaps...
July 10, 2017: Curēus
https://www.readbyqxmd.com/read/28928655/effects-of-simvastatin-beyond-dyslipidemia-exploring-its-antinociceptive-action-in-an-animal-model-of-complex-regional-pain-syndrome-type-i
#3
Graziela Vieira, Juliana Cavalli, Elaine C D Gonçalves, Tainara R Gonçalves, Larissa R Laurindo, Maíra Cola, Rafael C Dutra
Simvastatin is a lipid-lowering agent that blocks the production of cholesterol through inhibition of 3-hydroxy-methyl-glutaryl coenzyme A (HMG-CoA) reductase. In addition, recent evidence has suggested its anti-inflammatory and antinociceptive actions during inflammatory and pain disorders. Herein, we investigated the effects of simvastatin in an animal model of complex regional pain syndrome-type I, and its underlying mechanisms. Chronic post-ischemia pain (CPIP) was induced by ischemia and reperfusion (IR) injury of the left hind paw...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28928638/affective-circuitry-alterations-in-patients-with-trigeminal-neuralgia
#4
Dave J Hayes, David Q Chen, Jidan Zhong, Ariel Lin, Brendan Behan, Matthew Walker, Mojgan Hodaie
Trigeminal neuralgia (TN) is a severe chronic neuropathic facial pain disorder. Affect-related behavioral and structural brain changes have been noted across chronic pain disorders, but have not been well-studied in TN. We examined the potential impact of TN (37 patients: 23 with right-sided TN, 14 with left-sided TN), compared to age- and sex-matched healthy controls, on three major white matter tracts responsible for carrying affect-related signals-i.e., cingulum, fornix, and medial forebrain bundle. Diffusion magnetic resonance imaging (dMRI), deterministic multi-tensor tractography for tract modeling, and a model-driven region-of-interest approach was used...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28926645/alterations-in-regional-homogeneity-of-resting-state-cerebral-activity-in-patients-with-chronic-prostatitis-chronic-pelvic-pain-syndrome
#5
Yusong Lin, Yan Bai, Peng Liu, Xuejuan Yang, Wei Qin, Jianqin Gu, Degang Ding, Jie Tian, Meiyun Wang
The purpose of this study was to explore the neural mechanism in Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) using resting-state functional magnetic resonance imaging. The functional magnetic resonance imaging was performed on 31 male CP/CPPS-patients and 31 age and education matched male healthy controls on a 3-T magnetic resonance imaging unit. A two-sample t-test was adopted to reveal the regional homogeneity between the patients and healthy controls. The mean regional homogeneity values in the alerted brain regions of patients were correlated with the clinical measurements by using Pearson's correlation analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28924294/meatal-obstruction-following-canal-wall-down-mastoidectomy
#6
Nazim Bozan, Ufuk Duzenli, Pinar Kundi, Mahfuz Turan, Ahmet Faruk Kiroglu
Chronic otitis media (COM) is completely treated with a single procedure in most patients but may require multiple surgeries in some cases. The main goals of open cavity mastoidectomy are to completely eradicate the disease, create a large enough meatus for examination and mastoid air cells, and provide a self-cleaning epithelized dry cavity, and achieve maximum hearing. In this report, we present a very rare case of COM who underwent revision mastoidectomy in our clinic due to meatal obstruction in the right ear, total sensorineural hearing loss, and pain and tenderness in the postauricular region...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28923147/idiopathic-syringomyelia-in-a-military-helicopter-pilot
#7
Anthony Schiemer
BACKGROUND: A syrinx is a fluid-filled cavity within the spinal cord. They can lead to a variety of symptoms, including limb weakness and back pain. Incidental finding of syringomyelia provides a challenge for clinicians due to the wide variety of possible symptoms. In military aviation, neurological findings in pilots can result in extensive investigation that can lead to potentially invasive management. Conversely, the potential for chronic progression of a spinal syrinx and subsequent neurological deterioration makes early identification critical...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28922081/clinical-outcomes-following-conservative-management-of-chronic-traumatic-cervical-myelopathy-a-case-report
#8
Justin Bridges, Roberto Sandoval
BACKGROUND AND PURPOSE: There is limited evidence supporting the conservative management of patients with cervical myelopathy. The purpose of this report is to describe the intervention and outcomes of conservative physical therapy interventions for one patient with chronic cervical myelopathy. CASE DESCRIPTION: This case was a 50-year-old male who sustained a neck injury following a rear-end collision 4 years prior to this therapeutic episode. The patient presented with decreased range of motion in the cervical spine and right upper extremity, strength deficits, altered sensation, poor posture, and reported chronic cervical region pain and difficulty sleeping...
September 18, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28919432/chronic-pain-and-telomere-length-in-community-dwelling-adults-findings-from-the-1999-2002-national-health-and-nutrition-examination-survey
#9
Alta M Steward, Julia D Morgan, Juan P Espinosa, Dennis C Turk, Kushang V Patel
Chronic pain is a common condition associated with psychological distress, functional impairments, and age-associated comorbidity. Preliminary studies, based on relatively small sample sizes, suggest that the combination of chronic pain and stress is associated with telomere shortening, a widely recognized marker of cellular aging. We sought to determine the cross-sectional association of chronic pain with telomere length in 7,816 community-dwelling adults ages 20 and older who participated in the 1999-2002 National Health and Nutrition Examination Survey...
September 12, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28915430/care-interrupted-poverty-in-migration-and-primary-care-in-rural-resource-towns
#10
Kathleen Rice, Fiona Webster
Internationally, rural people have poorer health outcomes relative to their urban counterparts, and primary care providers face particular challenges in rural and remote regions. Drawing on ethnographic fieldnotes and 14 open-ended qualitative interviews with care providers and chronic pain patients in two remote resource communities in Northern Ontario, Canada, this article examines the challenges involved in providing and receiving primary care for complex chronic conditions in these communities. Both towns struggle with high unemployment in the aftermath of industry closure, and are characterized by an abundance of affordable housing...
September 4, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28914784/antiallodynic-effects-of-bee-venom-in-an-animal-model-of-complex-regional-pain-syndrome-type-1-crps-i
#11
Sung Hyun Lee, Jae Min Lee, Yun Hong Kim, Jung Hyun Choi, Seung Hwan Jeon, Dong Kyu Kim, Hyeon Do Jeong, You Jung Lee, Hue Jung Park
Neuropathic pain in a chronic post-ischaemic pain (CPIP) model mimics the symptoms of complex regional pain syndrome type I (CRPS I). The administration of bee venom (BV) has been utilized in Eastern medicine to treat chronic inflammatory diseases accompanying pain. However, the analgesic effect of BV in a CPIP model remains unknown. The application of a tight-fitting O-ring around the left ankle for a period of 3 h generated CPIP in C57/Bl6 male adult mice. BV (1 mg/kg ; 1, 2, and 3 times) was administered into the SC layer of the hind paw, and the antiallodynic effects were investigated using the von Frey test and by measuring the expression of neurokinin type 1 (NK-1) receptors in dorsal root ganglia (DRG)...
September 15, 2017: Toxins
https://www.readbyqxmd.com/read/28895456/spatial-and-cellular-expression-patterns-of-erythropoietin-receptor-and-erythropoietin-during-a-42-day-post-lesional-time-course-after-graded-thoracic-spinal-cord-impact-lesions-in-the-rat
#12
Gesa Cohrs, Stephan Goerden, Ralf Lucius, Michael Synowitz, Maximilian Hubertus Mehdorn, Janka Held-Feindt, Friederike Knerlich-Lukoschus
Erythropoietin (Epo) exhibits promising neuroregenerative potential for spinal cord injury (SCI) and might be involved in other long-term sequelae, such as neuropathic pain development. The current studies investigated the time courses and spatial and cellular patterns of Epo and EpoR expression along the spinal axis after graded SCI. Male Long Evans rats received 100-kdyn, 150-kdyn, and 200-kdyn thoracic (T9) contusions from an Infinite Horizon Impactor. Sham controls received laminectomies. Anatomical and quantitative immunohistochemical analyses of the EpoR/Epo expression along the whole spinal axis were performed 7, 15, and 42 DPO after the lesioning...
September 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28893330/changes-in-resting-state-brain-networks-after-cognitive-behavioral-therapy-for-chronic-pain
#13
A Yoshino, Y Okamoto, G Okada, M Takamura, N Ichikawa, C Shibasaki, S Yokoyama, M Doi, R Jinnin, H Yamashita, M Horikoshi, S Yamawaki
BACKGROUND: Cognitive-behavioral therapy (CBT) is thought to be useful for chronic pain, with the pathology of the latter being closely associated with cognitive-emotional components. However, there are few resting-state functional magnetic resonance imaging (R-fMRI) studies. We used the independent component analysis method to examine neural changes after CBT and to assess whether brain regions predict treatment response. METHODS: We performed R-fMRI on a group of 29 chronic pain (somatoform pain disorder) patients and 30 age-matched healthy controls (T1)...
September 12, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28893174/antiproliferative-factor-apf-binds-specifically-to-sites-within-the-cytoskeleton-associated-protein-4-ckap4-extracellular-domain
#14
Burzin Chavda, Jun Ling, Thomas Majernick, Sonia Lobo Planey
BACKGROUND: Antiproliferative factor (APF) is a sialoglycopeptide elevated in the urine of patients with interstitial cystitis-a chronic, painful bladder disease. APF inhibits the proliferation of normal bladder epithelial cells and cancer cells in vitro, presumably by binding to its cellular receptor, cytoskeleton associated-protein 4 (CKAP4); however, the biophysical interaction of APF with CKAP4 has not been characterized previously. In this study, we used surface plasmon resonance (SPR) to explore the binding kinetics of the interaction of APF and as-APF (a desialylated APF analogue with full activity) to CKAP4...
September 11, 2017: BMC Biochemistry
https://www.readbyqxmd.com/read/28886046/effects-of-water-avoidance-stress-on-peripheral-and-central-responses-during-bladder-filling-in-the-rat-a-multidisciplinary-approach-to-the-study-of-urologic-chronic-pelvic-pain-syndrome-mapp-research-network-study
#15
Zhuo Wang, Harriet H Chang, Yunliang Gao, Rong Zhang, Yumei Guo, Daniel P Holschneider, Larissa V Rodriguez
Stress plays a role in the exacerbation and possibly the development of functional lower urinary tract disorders. Chronic water avoidance stress (WAS) in rodents is a model with high construct and face validity to bladder hypersensitive syndromes, such as interstitial cystitis/bladder pain syndrome (IC/BPS), characterized by urinary frequency and bladder hyperalgesia and heightened stress responsiveness. Given the overlap of the brain circuits involved in stress, anxiety, and micturition, we evaluated the effects chronic stress has on bladder function, as well as its effects on regional brain activation during bladder filling...
2017: PloS One
https://www.readbyqxmd.com/read/28883862/prevalence-of-chronic-pain-in-the-elderly-polish-population-results-of-the-polsenior-study
#16
Elzbieta Kozak-Szkopek, Katarzyna Broczek, Przemyslaw Slusarczyk, Katarzyna Wieczorowska-Tobis, Alicja Klich-Raczka, Aleksandra Szybalska, Malgorzata Mossakowska
INTRODUCTION: Pain is the most common complaint of elderly people. In Poland, no large studies on the prevalence of chronic pain in the elderly were conducted until recently. MATERIAL AND METHODS: The study was a part of the PolSenior project, a cross-sectional multidisciplinary study on ageing of the Polish population, and included a randomly selected group of 716 people aged 55-59 years, and 4979 people over 65 years. The survey was conducted through a standardized questionnaire...
August 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28880891/altered-right-anterior-insular-connectivity-and-loss-of-associated-functions-in-adolescent-chronic-fatigue-syndrome
#17
Laura Anne Wortinger, Merete Glenne Øie, Tor Endestad, Vegard Bruun Wyller
Impairments in cognition, pain intolerance, and physical inactivity characterize adolescent chronic fatigue syndrome (CFS), yet little is known about its neurobiology. The right dorsal anterior insular (dAI) connectivity of the salience network provides a motivational context to stimuli. In this study, we examined regional functional connectivity (FC) patterns of the right dAI in adolescent CFS patients and healthy participants. Eighteen adolescent patients with CFS and 18 aged-matched healthy adolescent control participants underwent resting-state functional magnetic resonance imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28873217/geriatrics-literature-2016-year-in-review
#18
Kaitlin Willham, Kenneth Covinsky, Eric Widera
We present 10 of the most effective articles from 2016 in geriatric medicine. They address wide-ranging topics including the use of antipsychotics for delirium in palliative care, fall prevention and mobility interventions, efficacy and potential risks of testosterone, cranberry capsules and their effect on bacteriuria and pyuria, beta-blockers after acute myocardial infarction in a nursing home population, the effect of a healthy lifestyle on disability, a goals-of-care intervention in individuals with advanced dementia, the benefits of regional anesthesia in hip repair, and mindfulness in chronic pain management...
September 5, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28870191/effectiveness-of-a-specific-manual-approach-to-the-suboccipital-region-in-patients-with-chronic-mechanical-neck-pain-and-rotation-deficit-in-the-upper-cervical-spine-study-protocol-for-a-randomized-controlled-trial
#19
Vanessa González Rueda, Carlos López de Celis, Martín Eusebio Barra López, Andoni Carrasco Uribarren, Sara Castillo Tomás, Cesar Hidalgo García
BACKGROUND: Mechanical neck pain is a highly prevalent problem in primary healthcare settings. Many of these patients have restricted mobility of the cervical spine. Several manual techniques have been recommended for restoring cervical mobility, but their effectiveness in these patients is unknown. The aim of the present study is to compare the effectiveness of two types of specific techniques of the upper neck region: the pressure maintained suboccipital inhibition technique (PMSIT) and the translatory dorsal glide mobilization (TDGM) C0-C1 technique, as adjuncts to a protocolized physiotherapy treatment of the neck region in subjects with chronic mechanical neck pain and rotation deficit in the upper cervical spine...
September 5, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28866048/subcutaneous-lipoatrophy-and-skin-depigmentation-secondary-to-tmj-intra-articular-corticosteroid-injection
#20
Nicolás Patricio Skármeta, Fernando Ariel Hormazábal, Juan Alvarado, Ana Maria Rodriguez
Chronic orofacial pain is a complex multidimensional experience that produces disability and impairment of normal mandibular function. Overall estimations of chronic orofacial pain prevalence are 7 to 11% of the general population. Temporomandibular disorders (TMDs) are one of the most prevalent chronic orofacial pain conditions, with temporomandibular joint (TMJ) arthralgia accounted for 30.1% of TMD patients. Interventional procedures are often used in pain and palliative medicine to achieve reasonable and cost-effective pain relief...
August 5, 2017: Journal of Oral and Maxillofacial Surgery
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