keyword
https://read.qxmd.com/read/33532657/infertility-management-in-women-with-polycystic-ovary-syndrome-a-review
#21
REVIEW
Anita Cunha, Ana Margarida Póvoa
Polycystic ovary syndrome is the most common endocrine disorder in women and a major cause of anovulatory infertility. Various medical options are used, alone or in combination, to treat subfertility associated with polycystic ovary syndrome. This narrative review was conducted to provide an update and summarize the available evidence on the management of polycystic ovary syndrome related infertility. A wide literature search was performed and preferably randomized controlled trials and systematic reviews were included...
January 2021: Porto Biomedical Journal
https://read.qxmd.com/read/33331128/comparison-of-the-effects-of-bilateral-and-unilateral-laparoscopic-ovarian-drilling-on-pregnancy-rates-in-infertile-patients-with-polycystic-ovary-syndrome
#22
JOURNAL ARTICLE
Gokce D Turgut, Baris Mulayim, Ceyda Karadag, Burak Karadag, Sezin A Tatar, Burcu A Yuksel
AIM: This study aims to investigate the effects of unilateral and bilateral laparoscopic ovarian drilling (LOD) on pregnancy rates in patients with clomiphene citrate (CC) resistant infertile polycystic ovary syndrome. METHODS: This prospective cohort study included 75 patients who were admitted to the Department of Obstetrics and Gynecology of the Antalya Training and Research Hospital between July 2016 and December 2017 and underwent LOD operation. Among these patients, 37 underwent unilateral laparoscopic ovarian drilling (ULOD) and 38 underwent bilateral laparoscopic ovarian drilling (BLOD)...
February 2021: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/33142702/molecular-mechanisms-of-laparoscopic-ovarian-drilling-and-its-therapeutic-effects-in-polycystic-ovary-syndrome
#23
REVIEW
Kok-Min Seow, Yi-Wen Chang, Kuo-Hu Chen, Chi-Chang Juan, Chen-Yu Huang, Li-Te Lin, Kuan-Hao Tsui, Yi-Jen Chen, Wen-Ling Lee, Peng-Hui Wang
Polycystic ovary syndrome (PCOS) is a common endocrinopathy, characterized by chronic anovulation, hyperandrogenism, and multiple small subcapsular cystic follicles in the ovary during ultrasonography, and affects 5-10% of women of reproductive age. PCOS is frequently associated with insulin resistance (IR) accompanied by compensatory hyperinsulinemia and, therefore, presents an increased risk of type 2 diabetes mellitus (DM). The pathophysiology of PCOS is unclear, and many hypotheses have been proposed. Among these hypotheses, IR and hyperandrogenism may be the two key factors...
October 31, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/32912889/successful-ivf-outcome-after-repeat-laparoscopic-ovarian-drilling-in-a-case-of-resistant-pcos
#24
JOURNAL ARTICLE
Reeta Mahey, Monica Gupta, Reeta Bansiwal, Ankita Sethi
Ovulation induction (OVI) is the first-line treatment option for infertile women with polycystic ovary syndrome (PCOS). We report a case of resistant PCOS who responded to OVI after laparoscopic ovarian drilling (LOD) but suffered miscarriages in first trimester on three occasions, had late-onset moderate ovarian hyperstimulation syndrome (OHSS) in one cycle and recurrent anovulation. She underwent one in vitro fertilisation (IVF) cycle but it resulted in poor oocyte yield (four oocytes) and failed conception...
September 9, 2020: BMJ Case Reports
https://read.qxmd.com/read/32558920/significance-of-pro-angiogenic-estrogen-metabolites-in-normal-follicular-development-and-follicular-growth-arrest-in-polycystic-ovary-syndrome
#25
JOURNAL ARTICLE
Soledad Henríquez, Paulina Kohen, Xia Xu, Claudio Villarroel, Alex Muñoz, Ana Godoy, Jerome F Strauss, Luigi Devoto
STUDY QUESTION: Do alterations in pro- and anti-angiogenic estrogen metabolites in follicular fluid (FF) contribute to the follicular growth arrest and anovulation associated with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: FF of PCOS women with anovulation have reduced levels of pro-angiogenic estrogen metabolites (EMs) and vascular endothelial growth factor (VEGF) compared to that of fertile women with regular menstrual cycles, but exogenous gonadotropins increase the pro-angiogenic EMs and VEGF levels in PCOS women...
July 1, 2020: Human Reproduction
https://read.qxmd.com/read/32478411/trends-in-metabolic-surgery-in-reproductive-age-women-in-australia
#26
JOURNAL ARTICLE
Sarah Skalecki, Stephen J Robson
Obesity and polycystic ovary syndrome (PCOS) are common and have important reproductive consequences: 'metabolic surgery' - bariatric surgery and laparoscopic ovarian drilling (LOD) - have roles in their management. Using national data to determine age-stratified incidence rates of these procedures, we found that bariatric surgery is much more common than LOD. While the uptake of bariatric surgery is rapidly increasing, there has been a decline in the use of LOD in young women. It seems likely that other forms of care for PCOS-related anovulation resistant to clomiphene, such as the use of letrozole or in vitro fertilisation, are taking the place of LOD...
August 2020: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://read.qxmd.com/read/32478041/protein-network-studies-on-pcos-biomarkers-with-s100a8-druggability-assessment-and-rna-aptamer-designing-to-control-its-cyst-migration-effect
#27
JOURNAL ARTICLE
Subramaniyan Manibalan, Ayyachamy Shobana, Manickam Kiruthika, Anant Achary, Madasamy Swathi, Renganathan Venkatalakshmi, Kandasamy Thirukumaran, K Suhasini, Sharon Roopathy
The prevalence of polycystic ovary syndrome (PCOS) has been gradually increasing among adult females worldwide. Laparoscopy drilling on ovary is the only available temporary solution with a high incidence of reoccurrence. S100A8 with S100A9 complex is believed to facilitate the cyst migration in PCOS condition. The high evident protein interaction network studies between PCOS biomarkers, cancer invasion markers, and the interactors of S100A8 confirm that this protein has strong interaction with other selective PCOS biomarkers, which may be associative in the immature cyst invasion process...
2020: Frontiers in Bioengineering and Biotechnology
https://read.qxmd.com/read/32289557/variation-of-laparoscopic-ovarian-drilling-for-clomiphene-citrate-resistant-patients-with-polycystic-ovary-syndrome-and-infertility-a-meta-analysis
#28
JOURNAL ARTICLE
Jing Zhang, Kunyan Zhou, Xiaoyan Luo, Meina Yang, Xiaoyang Shen, Liangzhi Xu
OBJECTIVE: To evaluate novel surgical variations of laparoscopic ovarian drilling (LOD) and compare with standard bilateral LOD. DATA SOURCES: Electronic databases were searched, including Cochrane database, CENTRAL, Ovid MEDLINE, Embase, PsycINFO, PubMed, Virtual Health Library, OpenSIGLE, ClinicalTrials.gov, ISRCTN, and The Chinese Clinical Trial Register in February 2019. METHODS OF STUDY SELECTION: Randomized controlled trials (RCTs) evaluating LOD for patients with clomiphene citrate-resistant polycystic ovary syndrome and infertility and reporting reproductive outcomes, surgical complications, serum indexes, menses resumption, and ultrasound results were included...
July 2020: Journal of Minimally Invasive Gynecology
https://read.qxmd.com/read/32048270/laparoscopic-ovarian-drilling-for-ovulation-induction-in-women-with-anovulatory-polycystic-ovary-syndrome
#29
JOURNAL ARTICLE
Esmée M Bordewijk, Ka Ying Bonnie Ng, Lidija Rakic, Ben Willem J Mol, Julie Brown, Tineke J Crawford, Madelon van Wely
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common condition affecting 8% to 13% of reproductive-aged women. In the past clomiphene citrate (CC) used to be the first-line treatment in women with PCOS. Ovulation induction with letrozole should be the first-line treatment according to new guidelines, but the use of letrozole is off-label. Consequently, CC is still commonly used. Approximately 20% of women on CC do not ovulate. Women who are CC-resistant can be treated with gonadotrophins or other medical ovulation-induction agents...
February 11, 2020: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/31980027/transvaginal-ovarian-drilling-followed-by-controlled-ovarian-stimulation-from-the-next-day-improves-ovarian-response-for-the-poor-responders-with-polycystic-ovary-syndrome-during-ivf-treatment-a-pilot-study
#30
JOURNAL ARTICLE
Bufang Xu, Mingjuan Zhou, Meiyu Cheng, Dan Zhang, Xian Wu, Chenchen Si, Lan Xia, Huihui Xu, Jian Li, Hsun-Ming Chang, Peter C K Leung, Aijun Zhang
BACKGROUND: Poor response patients with PCOS who are not susceptible to gonadotropin stimulation are more likely to have canceled cycles or poor clinical outcomes during IVF treatment. However, some limitations exist in the present therapies. In this study, we evaluated the effects of using the transvaginal ovarian drilling (TVOD) followed by controlled ovarian stimulation (COS) from the second day of these poor responders. METHODS: During IVF, 7 poor responders with PCOS and 28 PCOS patients (14 normal and 14 high responders) were recruited...
January 24, 2020: Reproductive Biology and Endocrinology: RB&E
https://read.qxmd.com/read/31845767/metformin-for-ovulation-induction-excluding-gonadotrophins-in-women-with-polycystic-ovary-syndrome
#31
JOURNAL ARTICLE
Abigail Sharpe, Lara C Morley, Thomas Tang, Robert J Norman, Adam H Balen
BACKGROUND: Polycystic ovary syndrome (PCOS) is characterised by infrequent or absent ovulation, and high levels of androgens and insulin (hyperinsulinaemia). Hyperinsulinaemia occurs secondary to insulin resistance and is associated with an increased biochemical risk profile for cardiovascular disease and an increased prevalence of diabetes mellitus. Insulin-sensitising agents such as metformin may be effective in treating PCOS-related anovulation. This is an update of Morley 2017 and only includes studies on metformin...
December 17, 2019: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/31710188/comparison-of-laparoscopic-ovarian-drilling-success-between-two-standard-and-dose-adjusted-methods-in-polycystic-ovary-syndrome-a-randomized-clinical-trial
#32
JOURNAL ARTICLE
Leili Hafizi, Maliheh Amirian, Yasmin Davoudi, Mona Jaafari, G Hazal Ghasemi
BACKGROUND: One of the treatment methods for increasing the ovarian response to ovulation induction in polycystic ovary syndrome (PCOS) is laparoscopic ovarian drilling (LOD). The optimal amount of the electrosurgical energy discharged in the ovaries to achieve maximum treatment response with minimal follicle injury is unknown. This study was performed to compare the success level of LOD by means of standard and dose-adjusted treatment methods among infertile clomiphene-resistant PCOS women...
January 2020: International Journal of Fertility & Sterility
https://read.qxmd.com/read/31710185/medical-and-surgical-treatment-of-reproductive-outcomes-in-polycystic-ovary-syndrome-an-overview-of-systematic-reviews
#33
REVIEW
Moustafa A Gadalla, Robert J Norman, Chau T Tay, Danielle S Hiam, Angela Melder, Jyotsna Pundir, Shakila Thangaratinam, Helena J Teede, Ben W J Mol, Lisa J Moran
Polycystic ovary syndrome (PCOS) is a common, complex condition that affects up to 18% of reproductiveaged women, causing reproductive, metabolic and psychological dysfunctions. We performed an overview and appraisal of methodological quality of systematic reviews that assessed medical and surgical treatments for reproductive outcomes in women with PCOS. Databases (MEDLINE, EMBASE, CINAHL PLUS and PROSPERO) were searched on the 15th of September 2017. We included any systematic review that assessed the effect of medical or surgical management of PCOS on reproductive, pregnancy and neonatal outcomes...
January 2020: International Journal of Fertility & Sterility
https://read.qxmd.com/read/31576080/laparoscopic-ovarian-drilling-reduces-testosterone-and-luteinizing-hormone-follicle-stimulating-hormone-ratio-and-improves-clinical-outcome-in-women-with-polycystic-ovary-syndrome
#34
JOURNAL ARTICLE
Priyanka Sinha, Thyagaraju Chitra, Dasari Papa, Hanumanthappa Nandeesha
Background: Laparoscopic ovarian drilling (LOD) is one of the common modes of treatment for women with polycystic ovary syndrome (PCOS) who are resistant to clomiphene citrate. The data related to the effect of LOD on sex hormones are limited. Aim: The objective of the study was to investigate the effect of LOD on hormonal parameters and clinical outcomes in women with PCOS. Settings and Design: This study was conducted in a tertiary care hospital...
July 2019: Journal of Human Reproductive Sciences
https://read.qxmd.com/read/31497757/ovarian-drilling-in-polycystic-ovary-syndrome-long-term-pregnancy-rate
#35
JOURNAL ARTICLE
E Debras, H Fernandez, M-E Neveu, X Deffieux, P Capmas
Objective: To report long term pregnancy rate in polycystic ovary syndrome (PCOS) treated by ovarian drilling. To evaluate predictive factors of pregnancy and possibility of a second drilling. Design: Retrospective, observational, multicenter study. Setting: Gynecologic departments of two teaching's hospitals. Patients: All infertile women with PCOS who were treated by ovarian drilling from 2004 to 2013. The Rotterdam criteria were applied to define PCOS...
October 2019: European journal of obstetrics & gynecology and reproductive biology: X
https://read.qxmd.com/read/31416144/the-prevalence-of-incidental-endometriosis-in-women-undergoing-laparoscopic-ovarian-drilling-for-clomiphene-resistant-polycystic-ovary-syndrome-a-retrospective-cohort-study-and-meta-analysis
#36
JOURNAL ARTICLE
Marlene Hager, René Wenzl, Sonja Riesenhuber, Julian Marschalek, Lorenz Kuessel, Daniel Mayrhofer, Robin Ristl, Christine Kurz, Johannes Ott
To evaluate the incidence of endometriosis in polycystic ovary syndrome (PCOS) patients who did not present with any endometriosis symptoms and underwent laparoscopic ovarian drilling (LOD) for clomiphene citrate (CC) resistance, 225 and 630 women with CC-resistant PCOS without classic endometriosis symptoms were included in a retrospective study and a meta-analysis, respectively. All women underwent LOD. The main outcome parameter was the prevalence of incidental endometriosis. Laparoscopy revealed endometriosis in 38/225 (16...
August 14, 2019: Journal of Clinical Medicine
https://read.qxmd.com/read/31336507/serum-irisin-levels-in-polycystic-ovary-syndrome-after-ovarian-drilling
#37
JOURNAL ARTICLE
Ashraf A Foda, Engy A Foda, Zeinab H El-Said
BACKGROUND: Many cases of Poly-Cystic Ovary Syndrome (PCOS) are overweight and presenting with insulin resistance. MAIN OBJECTIVE: was to evaluate the effects of ovarian drilling on the serum levels of Irisin in women with polycystic ovaries. STUDY DESIGN AND SETTING: Serum Irisin levels were investigated in 100 cases with PCOS before ovarian drilling and 3 months after drilling, and in 80 control cases. Serum Irisin, hormonal profile and HOMA-IR were estimated in PCOS cases before and after ovarian drilling...
March 2019: Diabetes & Metabolic Syndrome
https://read.qxmd.com/read/30058861/pcos-and-pregnancy-a-review-of-available-therapies-to-improve-the-outcome-of-pregnancy-in-women-with-polycystic-ovary-syndrome
#38
REVIEW
Paolo Giovanni Artini, Maria Elena Rosa Obino, Claudia Sergiampietri, Sara Pinelli, Francesca Papini, Elena Casarosa, Vito Cela
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a common cause of female infertility affecting multiple aspects of a women's health. AREAS COVERED: The aim of this review is to summarize the existing evidence on the treatment of PCOS patients and to examine the actual available therapies to overcome the problem of infertility and improve the outcome of pregnancy. We analyse different treatment strategies such as lifestyle modification, bariatric surgery, insulin sensitizing agents, inositol, clomiphene citrate (CC), aromatase inhibitors, gonadotrophins, laparoscopic ovarian drilling, and assisted reproductive techniques (ART)...
March 2018: Expert Review of Endocrinology & Metabolism
https://read.qxmd.com/read/29797697/aromatase-inhibitors-letrozole-for-subfertile-women-with-polycystic-ovary-syndrome
#39
REVIEW
Sebastian Franik, Stephanie M Eltrop, Jan Am Kremer, Ludwig Kiesel, Cindy Farquhar
BACKGROUND: Polycystic ovary syndrome (PCOS) is the most common cause of infrequent periods (oligomenorrhoea) and absence of periods (amenorrhoea). It affects about 4% to 8% of women worldwide and often leads to anovulatory subfertility. Aromatase inhibitors (AIs) are a class of drugs that were introduced for ovulation induction in 2001. Since about 2001 clinical trials have reached differing conclusions as to whether the AI letrozole is at least as effective as the first-line treatment clomiphene citrate (CC)...
May 24, 2018: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/29476810/impact-of-ultrasound-guided-transvaginal-ovarian-needle-drilling-versus-laparoscopic-ovarian-drilling-on-ovarian-reserve-and-pregnancy-rate-in-polycystic-ovary-syndrome-a-randomized-clinical-trial
#40
RANDOMIZED CONTROLLED TRIAL
Mohamed Kandil, Mohamed Rezk, Alaa Al-Halaby, Mohamed Emarh, Ibrahim Saif El-Nasr
STUDY OBJECTIVE: To compare the impact of ultrasound-guided transvaginal ovarian needle drilling (TND) versus laparoscopic ovarian drilling (LOD) on ovarian reserve and pregnancy rate in patients with clomiphene citrate (CC)-resistant polycystic ovary syndrome (PCOS). DESIGN: A randomized clinical trial (Canadian Task Force classification I). SETTING: A university hospital. PATIENTS: Of 644 patients who presented at an infertility clinic, 246 with CC-resistant PCOS were randomized for treatment...
September 2018: Journal of Minimally Invasive Gynecology
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