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melanoma prostate cancer

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https://www.readbyqxmd.com/read/28095330/usnic-acid-and-atranorin-exert-selective-cytostatic-and-anti-invasive-effects-on-human-prostate-and-melanoma-cancer-cells
#1
A Galanty, P Koczurkiewicz, D Wnuk, M Paw, E Karnas, I Podolak, M Węgrzyn, M Borusiewicz, Z Madeja, J Czyż, M Michalik
OBJECTIVES AND METHODS: Lichens are an interesting source of potential anti-tumor compounds, among which usnic acid and atranorin seem to be the most promising, but their impact on invasive potential of tumor cells has not yet been comprehensively addressed. The aim of the study was focused on the impact of the two lichen metabolites, on the viability (by Trypan blue test and fluoresceine diacetate and ethidium bromide assay), proliferation (cell counting in a Bürker's chamber), apoptosis (flow cytometry analysis and Western blot) and motile activity (cell movement recording and image analysis) and actin cytoskeleton organization (immunofluorescent staining) of melanoma HTB-140, prostate cancers DU-145 and PC-3, normal human skin fibroblasts and prostate epithelial PNT2 cells, with special emphasis to their selectivity and versatility...
January 14, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28068157/cancer-survivors-preference-for-follow-up-care-providers-a-cross-sectional-study-from-the-population-based-profiles-registry
#2
Lotte J Huibertse, Mies van Eenbergen, Belle H de Rooij, Maarten T Bastiaens, Laurent M C L Fossion, Rob B de la Fuente, Paul J M Kil, Evert L Koldewijn, A H P Meier, Roland J M Mommers, A Q Niemer, Jorg R Oddens, Eric H G M Oomens, Mandy Prins, Kees-Peter de Roos, Monique R T M Thissen, Martine W H Timmermans, Bart P Wijsman, Lonneke V van de Poll-Franse, Nicole P M Ezendam
BACKGROUND: The best practice for the organization of follow-up care in oncology is under debate, due to growing numbers of cancer survivors. Understanding survivors' preferences for follow-up care is elementary for designing patient-centred care. Based on data from prostate cancer and melanoma survivors, this study aims to identify: 1) preferences for follow-up care providers, for instance the medical specialist, the oncology nurse or the general practitioner; 2) characteristics associated with these preferences and 3) the preferred care provider to discuss cancer-related problems...
January 9, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28062833/cancer-incidence-in-cohorts-of-workers-in-the-rubber-manufacturing-industry-first-employed-since-1975-in-the-uk-and-sweden
#3
M Boniol, A Koechlin, T Sorahan, K Jakobsson, P Boyle
OBJECTIVES: Increased cancer risks have been reported among workers in the rubber manufacturing industry employed before the 1960s, but it is unclear for workers hired subsequently. The present study focused on cancer incidence among rubber workers first employed after 1975 in Sweden and the UK. METHODS: Two cohorts of rubber workers employed for at least 1 year were analysed. Standardised incidence ratios (SIRs), based on country-specific and period-specific incidence rates, were analysed for all cancers combined (except non-melanoma skin), bladder, lung, stomach cancer, leukaemia, non-Hodgkin's lymphoma and multiple myeloma...
January 6, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28057523/surface-engineering-tumor-cells-with-adjuvant-loaded-particles-for-use-as-cancer-vaccines
#4
Kawther K Ahmed, Sean M Geary, Aliasger K Salem
Cell surface engineering is an expanding field and whilst extensive research has been performed decorating cell surfaces with biomolecules, the engineering of cell surfaces with particles has been a largely unexploited area. This study reports on the assembly of cell-particle hybrids where irradiated tumor cells were surface engineered with adjuvant-loaded, biodegradable, biocompatible, polymeric particles, with the aim of generating a construct capable of functioning as a therapeutic cancer vaccine. Successfully assembled cell-particle hybrids presented here comprised either melanoma cells or prostate cancer cells stably adorned with Toll-like receptor-9 ligand-loaded particles using streptavidin-biotin cross-linking...
January 3, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28052685/occurrence-of-malignancies-after-kidney-transplantation-in-adults-slovak-multicenter-experience
#5
Z Zilinska, M Sersenova, M Chrastina, J Breza Sr, L Bena, T Baltesova, A Jurcina, R Roland, E Lackova, M Cellar, L Laca, I Dedinska
Malignancies are one of the three major causes of renal recipient´s death with a functioning graft after cardiovascular diseases and infections. Among the variety of risk factors, including conventional and specific to transplant recipients, the duration of immunosuppressive therapy, the intensity of therapy, and the type of immunosuppressive agent all have an impact on development of post-transplant malignancy. The aim of our retrospective study was to document the incidence, the type of malignancies, the patient/graft survival in the group of kidney transplant recipients in Slovak Republic, and to identify the factors which influenced the outcome...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28049538/risk-of-second-cancer-following-radiotherapy-for-prostate-cancer-a-population-based-analysis
#6
Nina-Sophie Hegemann, Anne Schlesinger-Raab, Ute Ganswindt, Claudia Hörl, Stephanie E Combs, Dieter Hölzel, Jürgen E Gschwend, Christian Stief, Claus Belka, Jutta Engel
BACKGROUND: To investigate the risk of second cancer and radiation induced second cancer following prostate cancer radiotherapy. METHODS: We compared men with radiotherapy only with those treated with radical prostatectomy only and those with radiotherapy after radical prostatectomy. Cumulative incidences of second cancers were calculated. Cox analyses were performed to identify determinants influencing second cancer incidence. RESULTS: Nineteen thousand five hundred thirty eight patients were analyzed...
January 3, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28048586/th-ab-206-00-challenges-and-opportunities-for-nuclear-medicine-theranostics
#7
Osama Mawlawi
In the past few decades, the field of nuclear medicine has made long strides with the continued advancement of related sciences and engineering and the availability of diagnostic and therapeutic radionuclides. Leveraging these advancements while combining the advantages of therapeutic and diagnostic radionuclides into one radiopharmaceutical has also created a new subfield "theranostics" in nuclear medicine that has the potential to further propel the field into the future. This session is composed of two talks; one focused on the physics principles of theranostics from properties of beta and alpha emitting radionuclides to dosimetric models and quantification; while the second describes preclinical and clinical applications of theranostics and discusses the challenges and opportunities of bringing them to the clinic...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047028/th-ab-206-01-advances-in-radionuclide-therapy-from-radioiodine-to-nanoparticles
#8
J Humm
In the past few decades, the field of nuclear medicine has made long strides with the continued advancement of related sciences and engineering and the availability of diagnostic and therapeutic radionuclides. Leveraging these advancements while combining the advantages of therapeutic and diagnostic radionuclides into one radiopharmaceutical has also created a new subfield "theranostics" in nuclear medicine that has the potential to further propel the field into the future. This session is composed of two talks; one focused on the physics principles of theranostics from properties of beta and alpha emitting radionuclides to dosimetric models and quantification; while the second describes preclinical and clinical applications of theranostics and discusses the challenges and opportunities of bringing them to the clinic...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046372/th-ab-206-02-nuclear-medicine-theronostics-wave-of-the-future-pre-clinical-and-clinical-opportunities
#9
E Delpassand
In the past few decades, the field of nuclear medicine has made long strides with the continued advancement of related sciences and engineering and the availability of diagnostic and therapeutic radionuclides. Leveraging these advancements while combining the advantages of therapeutic and diagnostic radionuclides into one radiopharmaceutical has also created a new subfield "theranostics" in nuclear medicine that has the potential to further propel the field into the future. This session is composed of two talks; one focused on the physics principles of theranostics from properties of beta and alpha emitting radionuclides to dosimetric models and quantification; while the second describes preclinical and clinical applications of theranostics and discusses the challenges and opportunities of bringing them to the clinic...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28032931/fkbp51-regulates-cell-motility-and-invasion-via-rhoa-signaling
#10
Miho Takaoka, Shun Ito, Yoshio Miki, Akira Nakanishi
FK506 binding protein 51 (FKBP51), a member of the immunophilin family, is involved in multiple signaling pathways, tumorigenesis, and chemoresistance. FKBP51 expression correlates with metastatic potential in melanoma and prostate cancer. However, the functions of FKBP51, particularly involving the regulation of cell motility and invasion, are not fully understood. We discovered two novel interacting partner proteins of FKBP51, i.e., deleted in liver cancer 1 (DLC1) and deleted in liver cancer 2 (DLC2), using immunoprecipitation and mass spectrometry...
December 29, 2016: Cancer Science
https://www.readbyqxmd.com/read/28024266/the-risk-of-being-depressed-is-significantly-higher-in-cancer-patients-than-in-the-general-population-prevalence-and-severity-of-depressive-symptoms-across-major-cancer-types
#11
T J Hartung, E Brähler, H Faller, M Härter, A Hinz, C Johansen, M Keller, U Koch, H Schulz, J Weis, A Mehnert
BACKGROUND: Depression is a common co-morbidity of cancer that has a detrimental effect on quality of life, treatment adherence and potentially survival. We conducted an epidemiological multi-center study including a population-based random comparison sample and estimated the prevalence of depressive symptoms by cancer site, thereby identifying cancer patients with the highest prevalence of depression. PATIENTS AND METHODS: We included 4020 adult cancer inpatients and outpatients from five distinct regions across Germany in a proportional stratified random sample based on the nationwide cancer incidence and a comparison group consisting of 5018 participants...
December 23, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/28013246/adherence-to-cancer-treatment-guidelines-influence-of-general-and-cancer-specific-guideline-characteristics
#12
Marianne J Heins, Judith D de Jong, Inge Spronk, Vincent K Y Ho, Mirian Brink, Joke C Korevaar
BACKGROUND: Guideline adherence remains a challenge in clinical practice, despite guidelines' ascribed potential to improve patient outcomes. We studied the level of adherence to recommendations from Dutch national cancer treatment guidelines, and the influence of general and cancer-specific guideline characteristics on adherence. METHODS: Based on data from a national cancer registry, adherence was evaluated for 15 treatment recommendations for breast, colorectal, prostate and lung cancer, and melanoma...
December 24, 2016: European Journal of Public Health
https://www.readbyqxmd.com/read/28001329/fna-biopsy-of-secondary-nonlymphomatous-malignancies-in-salivary-glands-a-multi-institutional-study-of-184-cases
#13
He Wang, Raza S Hoda, William Faquin, Esther Diana Rossi, Nihar Hotchandani, Tianlin Sun, Marc Pusztaszeri, Tommaso Bizzarro, Massimo Bongiovanni, Viren Patel, Nirag Jhala, Guido Fadda, Yun Gong
BACKGROUND: Secondary malignancies of salivary glands (SMSGs) are among the most common malignant neoplasms to involve the salivary glands. Fine-needle aspiration biopsy (FNAB) of SMSG can present diagnostic challenges. The current report presents the largest such FNAB series to date. METHODS: A search of the pathology database from 6 academic institutions identified 184 FNAB cases of nonlymphomatous SMSG. RESULTS: Of the 184 cases, 171 were of the parotid glands, and 13 were of the submandibular glands; 130 patients were men, and 54 were women, and the mean patient age at diagnosis was 68 years...
December 21, 2016: Cancer
https://www.readbyqxmd.com/read/27999388/cytoglobosins-h-and-i-new-antiproliferative-cytochalasans-from-deep-sea-derived-fungus-chaetomium-globosum
#14
Zhihan Zhang, Xitian Min, Junjun Huang, Yue Zhong, Yuehua Wu, Xiaoxia Li, Yinyue Deng, Zide Jiang, Zongze Shao, Lianhui Zhang, Fei He
Cytoglobosins H (1) and I (2), together with seven known cytochalasan alkaloids (3-9), were isolated from the deep-sea-derived fungus Chaetomium globosum. The structures of new compounds 1 and 2 were elucidated by extensive 1D and 2D NMR and mass spectroscopic data. All the compounds were evaluated for their antiproliferative activities against MDA-MB-231 human breast cancer cells, LNCaP human prostate cancer cells, and B16F10 mouse melanoma cells. Compound 6 showed significant antiproliferative activity against LNCaP and B16F10 cell lines with IC50 values of 0...
December 20, 2016: Marine Drugs
https://www.readbyqxmd.com/read/27981754/identification-of-predominant-phytochemical-compounds-and-cytotoxic-activity-of-wild-olive-leaves-olea-europaea-l-ssp-sylvestris-harvested-in-south-portugal
#15
Justyna Makowska-Wąs, Agnieszka Galanty, Joanna Gdula-Argasińska, Małgorzata Tyszka-Czochara, Agnieszka Szewczyk, Ricardo Nunes, Isabel de Carvalho, Marta Michalik, Paweł Paśko
This study has been aimed at providing a qualitative and quantitative evaluation of selected phytochemicals such as phenolic acids, flavonoids, oleuropein, fatty acids profile, and volatile oil compounds, present in wild olive leaves harvested in Portugal, as well as at determining their antioxidant and cytotoxic potential against human melanoma HTB-140 and WM793, prostate cancer DU-145 and PC-3, hepatocellular carcinoma Hep G2 cell lines, as well as normal human skin fibroblasts BJ and prostate epithelial cells PNT2...
December 16, 2016: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/27981365/association-of-worry-about-cancer-to-benefit-finding-and-functioning-in-long-term-cancer-survivors
#16
Salene M W Jones, Rebecca Ziebell, Rod Walker, Larissa Nekhlyudov, Borsika A Rabin, Stephanie Nutt, Monica Fujii, Jessica Chubak
PURPOSE: Worry about cancer recurrence or progression is associated with negative effects of cancer, such as worse physical functioning, but associations with positive changes post-cancer, such as benefit finding, are unknown. We measured the proportion of patients reporting frequent worry about cancer recurrence or progression and examined the association between worry about cancer recurrence or progression to benefit finding and functioning in cancer. METHODS: We surveyed 594 long-term (5-10 years post-diagnosis) survivors of cancer (breast, prostate, colorectal, lung, melanoma) in this cross-sectional study...
December 15, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27978787/synthesis-and-antiproliferative-activity-of-new-pyrazolo-3-4-c-pyridines
#17
Efthymios-Spyridon Gavriil, Nikolaos Lougiakis, Nicole Pouli, Panagiotis Marakos, Alexios-Leandros Skaltsounis, Sangkil Nam, Richard Jove, David Horne, Katerina Gioti, Harris Pratsinis, Dimitris Kletsas, Roxane Tenta
BACKGROUND: Several pyrazolopyridines possess promising pharmacological activities, mainly attributed to their antagonistic nature towards the natural purines in many biological processes. Cytotoxicity and anticancer potential of this class of compounds is mainly related to induction of apoptotic cell death and inhibition of protein kinases. OBJECTIVES: This prompted us to design, synthesize and study the antiproliferative activity of a number of new 3,7-disubstituted pyrazolo[3,4-c] pyridines...
December 13, 2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/27976415/up-regulation-of-follistatin-like-1-by-the-androgen-receptor-and-melanoma-antigen-a11-in-prostate-cancer
#18
Shifeng Su, Amanda B Parris, Gail Grossman, James L Mohler, Zengjun Wang, Elizabeth M Wilson
BACKGROUND: High affinity androgen binding to the androgen receptor (AR) activates genes required for male sex differentiation and promotes the development and progression of prostate cancer. Human AR transcriptional activity involves interactions with coregulatory proteins that include primate-specific melanoma antigen-A11 (MAGE-A11), a coactivator that increases AR transcriptional activity during prostate cancer progression to castration-resistant/recurrent prostate cancer (CRPC). METHODS: Microarray analysis and quantitative RT-PCR were performed to identify androgen-regulated MAGE-A11-dependent genes in LAPC-4 prostate cancer cells after lentivirus shRNA knockdown of MAGE-A11...
December 14, 2016: Prostate
https://www.readbyqxmd.com/read/27922666/antimicrobial-peptide-ll-37-promotes-yb-1-expression-and-the-viability-migration-and-invasion-of-malignant-melanoma-cells
#19
Jinjing Jia, Yan Zheng, Wei Wang, Yongping Shao, Zhengxiao Li, Qiong Wang, Yuan Wang, Huling Yan
The cathelicidin antimicrobial peptide, LL-37, is a multifunctional peptide with a broad spectrum of antimicrobial activities, such as chemotaxis and neutralizing endotoxins. Previous studies have demonstrated that it LL‑37 serves a functional role in the development of numerous types of cancer including ovarian, breast, prostate and lung cancer. However, its role in the development of malignant melanoma (MM) remains unclear. To determine the role of LL‑37 and the potential interaction with Y-box binding protein 1 (YB‑1) in MM, RNA interference, western blot, reverse transcription-quantitative polymerase chain reaction, MTT and Transwell assays were performed...
January 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27895781/9-aaa-inhibits-growth-and-induces-apoptosis-in-human-melanoma-a375-and-rat-prostate-adenocarcinoma-at-2-and-mat-lylu-cell-lines-but-does-not-affect-the-growth-and-viability-of-normal-fibroblasts
#20
Włodzimierz Korohoda, Anna Hapek, Monika Pietrzak, Damian Ryszawy, Zbigniew Madeja
The present study found that, similarly to 5-fluorouracil, low concentrations (1-10 µM) of 9-aminoacridine (9-AAA) inhibited the growth of the two rat prostate cancer AT-2 and Mat-LyLu cell lines and the human melanoma A375 cell line. However, at the same concentrations, 9-AAA had no effect on the growth and apoptosis of normal human skin fibroblasts (HSFs). The differences between the cellular responses of the AT-2 and Mat-LyLu cell lines, which differ in malignancy, were found to be relatively small compared with the differences between normal HSFs and the cancer cell lines...
November 2016: Oncology Letters
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