Hanaa M Hassan, Asmaa M Abdeen, Ibrahim Y Abdelrahman, Walied Abdo, Saher S Mohammed, Ahmed Abdeen, Afaf Abdelkader, Rada Olga, Liana Fericean, Samah F Ibrahim, Heba I Ghamry, Farouk S Elgendy, Safwa M Sorour, Abeer A Eldeeb, Osama Ahmed, Fatema Rashed, Maha M Bikheet
Introduction: Ionizing radiation (IR) is effectively used in the treatment of oral malignancies; however, it might also significantly harm the surrounding tissues. Whey protein isolate (WP) is a protein derived from milk that exhibits a wide range of bioactivities. Therefore, the present research aimed to delineate the mitigating impact of WP against gamma irradiation-induced lingual damage. Methods: Rats were randomized into 5 groups: Control (saline, orally, 14 days), WP (WP; 0.5 g/kg b. w., orally, 14 days), IR (saline, orally, 14 days, exposed to 6 and 3 Gy on days 4 and 6, respectively), WP+IR (WP was given orally for 14 days before and after IR exposure; exposed to 6 and 3 Gy on days 4 and 6, respectively), and IR+WP (WP, orally, started 24 h after 1st IR exposure till the end of the experiment) groups...
2023: Frontiers in Pharmacology