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https://www.readbyqxmd.com/read/29140969/risk-factors-for-ventilator-associated-events-in-a-picu
#1
Raeley Guess, Jarin Vaewpanich, Jorge A Coss-Bu, Siriporn Phongjitsiri, Curtis Kennedy, Jeffrey Starke, Satid Thammasitboon
OBJECTIVE: The term ventilator-associated events includes ventilator-associated condition, infection-related ventilator-associated complication, and ventilator-associated pneumonia. We sought to identify potential new risk factors for ventilator-associated condition and infection-related ventilator-associated complication in the PICU population. DESIGN: Matched case control study. SETTING: Children's hospital at a tertiary care academic medical center...
November 14, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29140580/enhanced-biological-fixation-of-ligaments-to-bone-tissues-utilizing-chitin-fabrics
#2
Hisaya Nomata, Michiko Nakaishi, Kazuo Takakuda
In ligament reconstruction involving anterior cruciate ligament surgery, biological fixation between the transferred ligament and bone tissue is critical for achieving successful outcomes. Here, we administered chitin fabrics into the bone tunnels and evaluated their efficacy in promoting biological fixation. An animal model on the rat's patellar ligament was employed. First, bone tunnels were created in the lateral condyle of the femur. The ligament was then separated from the tibial tuberosity, and half was inserted into the tunnel and fixed with the use of end button...
November 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29140226/childhood-inflammatory-markers-and-intelligence-as-predictors-of-subsequent-persistent-depressive-symptoms-a-longitudinal-cohort-study
#3
G M Khandaker, J Stochl, S Zammit, I Goodyer, G Lewis, P B Jones
BACKGROUND: To identify developmental sub-groups of depressive symptoms during the second decade of life, a critical period of brain development, using data from a prospective birth cohort. To test whether childhood intelligence and inflammatory markers are associated with subsequent persistent depressive symptoms. METHODS: IQ, a proxy for neurodevelopment, was measured at age 8 years. Interleukin 6 (IL-6) and C-reactive protein, typical inflammatory markers, were measured at age 9 years...
November 15, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29139014/the-ictal-interictal-continuum-to-treat-or-not-to-treat-and-how
#4
Clio Rubinos, Alexandra S Reynolds, Jan Claassen
Continuous electroencephalography (cEEG) monitoring is becoming increasingly used in neurologic and non-neurologic intensive care units (ICUs). Non-convulsive seizures (NCSz) and periodic discharges (PDs) are commonly seen in critically ill patients. Some of these PD patterns, also known as the ictal-interictal continuum (IIC), are associated with an increased risk of seizures and poor outcome. However, we do not fully understand the significance of these periodic patterns and the decision of how aggressively to treat remains controversial...
November 14, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/29138421/mperiod2-brdm1-and-other-single-period-mutant-mice-have-normal-food-anticipatory-activity
#5
Julie S Pendergast, Robert H Wendroth, Rio C Stenner, Charles D Keil, Shin Yamazaki
Animals anticipate the timing of food availability via the food-entrainable oscillator (FEO). The anatomical location and timekeeping mechanism of the FEO are unknown. Several studies showed the circadian gene, Period 2, is critical for FEO timekeeping. However, other studies concluded that canonical circadian genes are not essential for FEO timekeeping. In this study, we re-examined the effects of the Per2 (Brdm1) mutation on food entrainment using methods that have revealed robust food anticipatory activity in other mutant lines...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29137645/distribution-of-essential-medicines-to-primary-care-institutions-in-hubei-of-china-effects-of-centralized-procurement-arrangements
#6
Lianping Yang, Cunrui Huang, Chaojie Liu
BACKGROUND: Poor distribution of essential medicines to primary care institutions has attracted criticism since China adopted provincial centralized regional tendering and procurement systems. This study evaluated the impact of new procurement arrangements that limit the number of distributors at the county level in Hubei province, China. METHODS: Procurement ordering and distribution data were collected from four counties that pioneered a new distribution arrangement (commencing September 2012) compared with six counties that continued the existing arrangement over the period from August 2011 to September 2013...
November 14, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29136784/the-alternation-of-autophagy-apoptosis-in-cd4-cd25-foxp3-tregs-on-the-developmental-stages-of-atherosclerosis
#7
Yuling Tian, Xiao Liang, Yue Wu
Naturally regulatory T cells (Tregs) play a critical role in the regulation of T cell-mediated immune responses in atherosclerosis. However, the regulatory mechanism underlying Tregs upon long-term development of atherosclerosis remains unknown. Therefore, in this study, atherosclerotic model was induced in ApoE-/- mice by feeding fat-diet for 10 weeks. Quantification of atherosclerotic lesions was done by calculating the lesion size in the aortic sinus every 2 weeks. The lipid levels and inflammatory mediators were detected in serum sample...
November 8, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136011/ten-year-experience-with-antiretroviral-treatment-in-cambodia-trends-in-patient-characteristics-and-treatment-outcomes
#8
Phirum Lay, Sokkab An, Sunpiseth Soeung, Pich Sovannary Srey, Sopheak Thai, Lutgarde Lynen, Johan van Griensven
BACKGROUND: Although HIV disease stage at ART initiation critically determines ART outcomes, few reports have longitudinally monitored this within Asia. Using prospectively collected data from a large ART program at Sihanouk Hospital Center of Hope in Cambodia, we report on the change in patient characteristics and outcomes over a ten-year period. METHODS: We conducted a retrospective analysis including all adults (≥ 18 years old) starting ART from March 2003-March 2013 in a non-governmental hospital in Phnom Penh, Cambodia...
2017: PloS One
https://www.readbyqxmd.com/read/29135881/maturity-indicators-and-adolescent-idiopathic-scoliosis-evaluation-of-the-sanders-maturity-scale
#9
Kevin M Neal, Eric D Shirley, Gary M Kiebzak
STUDY DESIGN: Retrospective review. OBJECTIVE: To determine the correlation between the Sanders Maturity Scale (SMS) and Risser stages, between both systems and menarche, and whether Risser can be used to predict SMS. SUMMARY OF BACKGROUND DATA: Predicting curve progression is critical to understanding adolescent idiopathic scoliosis and making treatment recommendations. The SMS is a better predictor of the curve acceleration phase of growth than the Risser stage...
November 10, 2017: Spine
https://www.readbyqxmd.com/read/29135844/magnet%C3%A2-enculturation
#10
M Maureen Lal
In this column, the senior manager for the Magnet Appraiser Program® relates the importance of the components of the journey to Magnet with developing and sustaining a culture of excellence through the appraisal period and beyond. Sustainment of excellence includes regular critical assessments and support in nursing practice, governance models, and resources throughout organizational settings where nursing is practiced.
December 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/29135652/are-hiv-seroconversions-among-young-men-who-have-sex-with-men-associated-with-social-network-proximity-to-recently-or-long-term-hiv-infected-individuals
#11
Ethan Morgan, Britt Skaathun, Rebeccah Duvoisin, Stuart Michaels, John A Schneider
Debate remains as to the relative HIV transmission contributions from individuals who are recently HIV infected and individuals who have long-term infections. In this study, we examine the relationship between new HIV seroconversions occurring among young Black men who have sex with men (YBMSM) and network proximity to recently or long-term HIV infected individuals. A cohort of YBMSM (N = 618) was generated through respondent driven sampling across three waves. A recent HIV infection was defined as either: 1) a confirmed seroconversion ≤9 months prior to interview date or 2) a laboratory confirmed acute infection; long-term HIV infected individuals were defined as a diagnosis date ≥9 months prior to interview date...
November 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29135438/exposure-to-perfluoroalkyl-substances-and-metabolic-outcomes-in-pregnant-women-evidence-from-the-spanish-inma-birth-cohorts
#12
Nuria Matilla-Santander, Damaskini Valvi, Maria-Jose Lopez-Espinosa, Cyntia B Manzano-Salgado, Ferran Ballester, Jesús Ibarluzea, Loreto Santa-Marina, Thomas Schettgen, Mònica Guxens, Jordi Sunyer, Martine Vrijheid
BACKGROUND: Exposure to perfluoroalkyl substances (PFASs) may increase risk for metabolic diseases; however, epidemiologic evidence is lacking at the present time. Pregnancy is a period of enhanced tissue plasticity for the fetus and the mother and may be a critical window of PFAS exposure susceptibility. OBJECTIVE: We evaluated the associations between PFAS exposures and metabolic outcomes in pregnant women. METHODS: We analyzed 1,240 pregnant women from the Spanish INMA [Environment and Childhood Project (INfancia y Medio Ambiente)] birth cohort study (recruitment period: 2003-2008) with measured first pregnancy trimester plasma concentrations of four PFASs (in nanograms/milliliter)...
November 13, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29135147/-biomarkers-of-renal-injury-in-contact-ureteral-lithotripsy
#13
A I Tarasenko, A M Pushkarev, I G Rakipov, A V Alekseev, Ya V Kondratenko, V N Pavlov
AIM: To optimize the transurethral endoscopic management of patients with ureterolithiasis by measuring biomarkers of renal parenchymal damage. MATERIALS AND METHODS: One hundred fifty-one patients with solitary ureteral stones were tested for levels of cystatin C, neutrophil gelatinase-associated lipocalin, 2-microglobulin and interleukin 18. RESULTS: An increase in the levels of markers of renal injury was observed both in the preoperative period and after CULT...
October 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/29134854/prediction-of-recidivism-with-the-youth-level-of-service-case-management-inventory-reduced-version-in-a-sample-of-young-spanish-offenders
#14
Keren Cuervo, Lidón Villanueva
Intervention in youth recidivism is critical in helping prevent young people from continuing their criminal career into adulthood, on a life-course-persistent trajectory. Andrews and Bonta attempt to provide an explanation of risk and protective factors using a conversion of the Youth Level of Service/Case Management Inventory (YLS/CMI), which predicts recidivism. In this study, scores have been obtained from 382 adolescents ( M age = 16.33 years) from the juvenile court, to check the ability of a reduced version of the YLS/CMI, to predict recidivism...
November 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29134717/superior-colliculus-resting-state-networks-in-post-traumatic-stress-disorder-and-its-dissociative-subtype
#15
Isadora Olivé, Maria Densmore, Sherain Harricharan, Jean Théberge, Margaret C McKinnon, Ruth Lanius
OBJECTIVES: The innate alarm system (IAS) models the neurocircuitry involved in threat processing in posttraumatic stress disorder (PTSD). Here, we investigate a primary subcortical structure of the IAS model, the superior colliculus (SC), where the SC is thought to contribute to the mechanisms underlying threat-detection in PTSD. Critically, the functional connectivity between the SC and other nodes of the IAS remains unexplored. EXPERIMENTAL DESIGN: We conducted a resting-state fMRI study to investigate the functional architecture of the IAS, focusing on connectivity of the SC in PTSD (n = 67), its dissociative subtype (n = 41), and healthy controls (n = 50) using region-of-interest seed-based analysis...
November 13, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29134297/community-based-efforts-to-prevent-and-manage-diabetes-in-women-living-in-vulnerable-communities
#16
Laurie Lachance, R Patrick Kelly, Margaret Wilkin, Jodi Burke, Sandra Waddell
Social determinants of health likely play a significant role in the development of type 2 diabetes for women in vulnerable communities. Adult African American women diagnosed with or at-risk for diabetes in Inkster, Michigan (n = 113) and a group of demographically similar women in Flint, Michigan (n = 48) participated in programs aimed at increasing diabetes-related self-management behaviors through peer coaching, health literacy training, and social support. Participants completed surveys to measure changes in health, health behaviors, health literacy, and social support...
November 13, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/29133329/involvement-of-people-with-dementia-in-making-decisions-about-their-lives-a-qualitative-study-that-appraises-shared-decision-making-concerning-daycare
#17
Leontine Groen-van de Ven, Carolien Smits, Fuusje de Graaff, Marijke Span, Jan Eefsting, Jan Jukema, Myrra Vernooij-Dassen
OBJECTIVE: To explore how people with dementia, their informal caregivers and their professionals participate in decision making about daycare and to develop a typology of participation trajectories. DESIGN: A qualitative study with a prospective, multiperspective design, based on 244 semistructured interviews, conducted during three interview rounds over the course of a year. Analysis was by means of content analysis and typology construction. SETTING: Community settings and nursing homes in the Netherlands...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29133211/beta-lactam-resistance-among-enterobacteriaceae-in-cambodia-the-four-year-itch
#18
REVIEW
Yannick Caron, Rattanak Chheang, Puthea Nop, Soda Meng, Sébastien Boyer, Arnaud Tarantola, Alexandra Kerléguer
Although antibiotics are too often used inappropriately in Cambodia, few data have been published on antimicrobial resistance in this country. Epidemic dissemination and the transfer of resistance genes to other bacterial species put the population at risk. The aim of this study was to evaluate the frequency and characteristics of extended-spectrum beta-lactamase (ESBL) enterobacteriaceae (ESBL-E) isolated in consecutive samples tested at Institut Pasteur du Cambodge (IPC) over a four-year period (2012-2015)...
November 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29132880/rivaroxaban-with-or-without-aspirin-in-patients-with-stable-peripheral-or-carotid-artery-disease-an-international-randomised-double-blind-placebo-controlled-trial
#19
Sonia S Anand, Jackie Bosch, John W Eikelboom, Stuart J Connolly, Rafael Diaz, Peter Widimsky, Victor Aboyans, Marco Alings, Ajay K Kakkar, Katalin Keltai, Aldo P Maggioni, Basil S Lewis, Stefan Störk, Jun Zhu, Patricio Lopez-Jaramillo, Martin O'Donnell, Patrick J Commerford, Dragos Vinereanu, Nana Pogosova, Lars Ryden, Keith A A Fox, Deepak L Bhatt, Frank Misselwitz, John D Varigos, Thomas Vanassche, Alvaro A Avezum, Edmond Chen, Kelley Branch, Darryl P Leong, Shrikant I Bangdiwala, Robert G Hart, Salim Yusuf
BACKGROUND: Patients with peripheral artery disease have an increased risk of cardiovascular morbidity and mortality. Antiplatelet agents are widely used to reduce these complications. METHODS: This was a multicentre, double-blind, randomised placebo-controlled trial for which patients were recruited at 602 hospitals, clinics, or community practices from 33 countries across six continents. Eligible patients had a history of peripheral artery disease of the lower extremities (previous peripheral bypass surgery or angioplasty, limb or foot amputation, intermittent claudication with objective evidence of peripheral artery disease), of the carotid arteries (previous carotid artery revascularisation or asymptomatic carotid artery stenosis of at least 50%), or coronary artery disease with an ankle-brachial index of less than 0·90...
November 10, 2017: Lancet
https://www.readbyqxmd.com/read/29132879/rivaroxaban-with-or-without-aspirin-in-patients-with-stable-coronary-artery-disease-an-international-randomised-double-blind-placebo-controlled-trial
#20
Stuart J Connolly, John W Eikelboom, Jackie Bosch, Gilles Dagenais, Leanne Dyal, Fernando Lanas, Kaj Metsarinne, Martin O'Donnell, Anthony L Dans, Jong-Won Ha, Alexandr N Parkhomenko, Alvaro A Avezum, Eva Lonn, Liu Lisheng, Christian Torp-Pedersen, Petr Widimsky, Aldo P Maggioni, Camilo Felix, Katalin Keltai, Masatsugu Hori, Khalid Yusoff, Tomasz J Guzik, Deepak L Bhatt, Kelley R H Branch, Nancy Cook Bruns, Scott D Berkowitz, Sonia S Anand, John D Varigos, Keith A A Fox, Salim Yusuf
BACKGROUND: Coronary artery disease is a major cause of morbidity and mortality worldwide, and is a consequence of acute thrombotic events involving activation of platelets and coagulation proteins. Factor Xa inhibitors and aspirin each reduce thrombotic events but have not yet been tested in combination or against each other in patients with stable coronary artery disease. METHODS: In this multicentre, double-blind, randomised, placebo-controlled, outpatient trial, patients with stable coronary artery disease or peripheral artery disease were recruited at 602 hospitals, clinics, or community centres in 33 countries...
November 10, 2017: Lancet
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