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Cardiac output studies in newborn

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https://www.readbyqxmd.com/read/27542806/2-aminoethyldiphenylborinate-modifies-the-pulmonary-circulation-in-pulmonary-hypertensive-newborn-lambs-with-partial-gestation-at-high-altitude
#1
Sebastián Castillo-Galán, Sebastián Quezada, Fernando A Moraga, Germán Ebensperger, Emilio A Herrera, Felipe Beñaldo, Ismael Hernandez, Renato Ebensperger, Santiago Ramirez, Anibal J Llanos, Roberto V Reyes
Calcium signaling through store operated channels (SOC) is involved in hypoxic pulmonary hypertension. We determined whether a treatment with 2-aminoethyldiphenylborinate (2-APB), a compound with SOC blocker activity, reduces pulmonary hypertension and vascular remodeling. Twelve newborn lambs exposed to perinatal chronic hypoxia were studied, 6 of them received a 2-APB treatment and the other 6 received vehicle treatment, for 10 days in both cases. Throughout this period, we recorded cardiopulmonary variables and on day 11 we evaluated the response to an acute hypoxic challenge...
August 19, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27529179/haemodynamic-transition-after-birth-a-new-tool-for-non-invasive-cardiac-output-monitoring
#2
Thomas Freidl, Nariae Baik, Gerhard Pichler, Bernhard Schwaberger, Barbara Zingerle, Alexander Avian, Berndt Urlesberger
BACKGROUND: Substantial haemodynamic changes occur during the first minutes after birth. Currently, only heart rate (HR) and arterial oxygen saturation are routinely used to monitor haemodynamic transition after birth. OBJECTIVES: The aim of the present study was to continuously assess haemodynamic changes during transition in term infants for the first time by using electrical velocimetry (EV), a new method of non-invasive cardiac output monitoring (NICOM), based on impedance cardiography technology...
August 17, 2016: Neonatology
https://www.readbyqxmd.com/read/27516657/caring-for-newborn-s-umbilical-cord-from-iranian-traditional-medicine-point-of-view
#3
Nayereh Vahedi Mazdabadi, Elahe Karimpour Razkenari, Mina Saeedi, Tahmineh Akbarzadeh, Mohammad Toushih
BACKGROUND: It is evident that infant's umbilical cord is essential for its survival and growth. In the past, it was not considered as a necessary tissue. However, nowadays, it has attracted lots of attention and its relation to different diseases has been demonstrated. In Iranian traditional medicine, caring for newborn's umbilical cord has been frequently recommended and it has been associated with different diseases. METHODS: Herein, Iranian traditional medicine resources such as "Qanun-fil-Tibb", "Exir-e-Azam", and "Tib-e-Akbari" were studied...
May 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27490740/inotropes-do-not-increase-cardiac-output-or-cerebral-blood-flow-in-preterm-piglets
#4
Yvonne A Eiby, Nicole Y Shrimpton, Ian M R Wright, Eugenie R Lumbers, Paul B Colditz, Greg J Duncombe, Barbara E Lingwood
BACKGROUND: The preterm newborn is at high risk of developing cardiovascular compromise during the first day of life and this is associated with increased risk of brain injury. Standard treatments are volume expansion and administration of inotropes, typically dopamine and/or dobutamine, but there is limited evidence that inotropes improve clinical outcomes. This study investigated the efficacy of dopamine and dobutamine for the treatment of cardiovascular compromise in the preterm newborn using a piglet model...
December 2016: Pediatric Research
https://www.readbyqxmd.com/read/27432486/the-use-of-neonatal-extracorporeal-life-support-in-pediatric-cardiac-intensive-care-unit
#5
Erkut Öztürk, Okan Yıldız, Nihat Çine, Behzat Tüzün, Selen Onan, Yakup Ergül, Alper Güzeltaş, Sertaç Haydin, Mehmet Yeniterzi, İhsan Bakır
AIM: The aim of the study is to evaluate extracorporeal life support system (ECLS) employed in neonates in pediatric cardiac intensive care unit. MATERIAL AND METHODS: Twenty-five neonates that required ECLS in between November 2010 and November 2015 were evaluated. RESULTS: The median age was 12 days (range 3-28 days) and the median body weight was 3 kg (range 2.5-5 kg). Venoarterial ECLS was performed in all of the cases. Ascendan aorta-right atrial cannulation in 22 patients and neck cannulation in three patients were performed...
August 10, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27159914/detection-and-quantification-of-left-to-right-shunting-using-transpulmonary-ultrasound-dilution-tpud-a-validation-study-in-neonatal-lambs
#6
Sabine L Vrancken, Arno F van Heijst, Jeroen C Hopman, Kian D Liem, Johannes G van der Hoeven, Willem P de Boode
OBJECTIVES: We investigated the accuracy of left-to-right shunt detection using transpulmonary ultrasound dilution (TPUD) and compared the agreement between pulmonary over systemic blood flow (Qp/Qs) ratio measured by TPUD [Qp/Qs(tpud)] and ultrasonic flow probes [Qp/Qs(ufp)]. METHODS: Seven newborn lambs under general anesthesia were connected to the TPUD monitor (COstatus™) after insertion of arterial and central venous catheters. A Gore-Tex® shunt, inserted between the descending aorta and left pulmonary artery, was intermittently opened and closed while cardiac output was varied by blood withdrawals...
May 9, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27057332/measuring-cardiac-changes-using-electrical-impedance-during-delayed-cord-clamping-a-feasibility-trial
#7
Anup C Katheria, Madeline Wozniak, David Harari, Kathy Arnell, Deborah Petruzzelli, Neil N Finer
BACKGROUND: To date no study has attempted to continuously evaluate changes in hemodynamics during delayed cord clamping in humans. We aimed to demonstrate 1. the feasibility of measurements of hemodynamics during delayed cord clamping and 2. to describe the changes that occur over each minute. RESULTS: After vaginal delivery, term infants (37(0)-41(6) weeks) were placed on a Life Start® bed 10-20 cm below the placenta. Transcutaneous sensors were placed on the neck and chest to determine heart rate, stroke volume and cardiac output at each beat...
2015: Maternal Health, Neonatology and Perinatology
https://www.readbyqxmd.com/read/26687150/initial-observations-of-the-effects-of-calcium-chloride-infusions-in-pediatric-patients-with-low-cardiac-output
#8
Konstantin Averin, Chet Villa, Catherine D Krawczeski, Jesse Pratt, Eileen King, John L Jefferies, David P Nelson, David S Cooper, Thomas D Ryan, Jaclyn Sawyer, Jeffrey A Towbin, Angela Lorts
Myocardial contractility and relaxation are highly dependent on calcium homeostasis. Immature myocardium, as in pediatric patients, is thought to be more dependent on extracellular calcium for optimal function. For this reason, intravenous calcium chloride infusions may improve myocardial function in the pediatric patient. The objectives of this study were to report the hemodynamic changes seen after administration of continuous calcium chloride to critically ill children. We retrospectively identified pediatric patients (newborn to 17 years old) with hemodynamic instability admitted to the cardiac ICU between May 2011 and May 2012 who received a continuous infusion of calcium chloride...
March 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/26365674/treatment-strategies-for-primary-tumors-of-the-heart-in-children-a-10-year-experience
#9
Xu Liu, Haifa Hong, Haibo Zhang, Zhiwei Xu, Jinfen Liu, Lisheng Qiu
BACKGROUND: The goal of this study was to determine the optimal treatment strategy for children with primary tumors of the heart. METHODS: We reviewed 88 children with primary heart tumors in our center from January 2004 to December 2013. Operative patients were followed every 6 months in the first postoperative year and then regularly every 12 months; nonoperative patients were followed once a year after diagnosis. Demographic information of imaging, operative details, and postoperative data were obtained from medical records...
November 2015: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/26346024/a-literature-review-of-the-pharmacokinetics-and-pharmacodynamics-of-dobutamine-in-neonates
#10
REVIEW
Liam Mahoney, Geetika Shah, David Crook, Hector Rojas-Anaya, Heike Rabe
Since its discovery in 1975 dobutamine has been used off-label for treating hemodynamic insufficiency in newborns and children. We present a structured literature review of pharmacokinetic and pharmacodynamic data for dobutamine in the pediatric population. Structured searches were conducted to identify relevant articles according to pre-defined inclusion criteria. Where possible, results for the pharmacodynamic and pharmacokinetic effect of dobutamine were reported as pooled data. Forty-six papers met the inclusion criteria...
January 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/26342630/effects-of-ventilation-modalities-on-near-infrared-spectroscopy-in-surgically-corrected-cdh-infants
#11
Andrea Conforti, Paola Giliberti, Francesca Landolfo, Laura Valfrè, Claudia Columbo, Vito Mondi, Irma Capolupo, Andrea Dotta, Pietro Bagolan
BACKGROUND: Near-infrared spectroscopy (NIRS) is a noninvasive technique for monitoring tissue oxygenation and perfusion. The aim of this study was to evaluate cerebral and splanchnic NIRS changes in CDH operated infants enrolled into the VICI trial and therefore randomized for ventilatory modalities. MATERIALS AND METHODS: CDH newborns enrolled into the VICI trial (Netherlands Trial Register, NTR 1310) were randomized at birth for high-frequency oscillatory ventilation (HFOV) or conventional mechanical ventilation (CMV) according to the trial...
March 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26221073/knockout-of-src-1-and-src-3-in-mice-decreases-cardiomyocyte-proliferation-and-causes-a-noncompaction-cardiomyopathy-phenotype
#12
Xian Chen, Li Qin, Zhaoliang Liu, Lan Liao, James F Martin, Jianming Xu
Noncompaction cardiomyopathy (NCC) is a congenital heart disease that causes ventricular dysfunction and high mortality rate in children. The mechanisms responsible for NCC are still unknown. The steroid receptor coactivator-1 (SRC-1) and SRC-3 are transcriptional coactivators for nuclear hormone receptors and certain other transcription factors that regulate many genes in development and organ function. However, the roles of SRC-1/3 in heart morphogenesis, function and NCC occurrence are unknown. This study aims to examine the spatial and temporal expression patterns of SRC-1/3 in the heart and investigate the specific roles of SRC-1/3 in heart development, function and NCC occurrence...
2015: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/26215925/tailoring-the-hybrid-palliation-for-hypoplastic-left-heart-syndrome-a-simulation-study-using-a-lumped-parameter-model
#13
A Di Molfetta, M Pilati, M G Gagliardi, L Fresiello, A Amodeo, A Cristofaletti, G Pongiglione, G Ferrari
The results of Hybrid procedure (HP) for the hypoplastic left heart syndrome (HLHS) depend on several variables: pulmonary artery banding tightness (PAB), atrial septal defect size (ASD) and patent ductus arteriosus stent size (PDA). A HP complication could be the aortic coarctaction (CoAo). The reverse Blalock-Taussig shunt (RevBT) placement was proposed to avoid CoAo effects. This work aims at developing a lumped parameter model (LPM) to investigate the effects of the different variables on HP haemodynamics...
September 2015: Medical Engineering & Physics
https://www.readbyqxmd.com/read/26212391/heart-rate-variability-analysis-is-more-sensitive-at-identifying-neonatal-sepsis-than-conventional-vital-signs
#14
Fredrick J Bohanon, Amy A Mrazek, Mohamed T Shabana, Sarah Mims, Geetha L Radhakrishnan, George C Kramer, Ravi S Radhakrishnan
BACKGROUND: Sepsis remains the largest preventable source of neonatal mortality in the world. Heart rate variability (HRV) analysis and noninvasive cardiac output have been shown to be useful adjuncts to sepsis detection in many patient groups. METHODS: With Institutional Review Board approval, 4 septic and 6 nonseptic extremely low birth weight patients were enrolled. Data from septic and healthy patients were collected for 5 hours. Electrocardiogram waveform and traditional vital signs were collected and the RR intervals were calculated; then HRV analysis was performed in both the time and frequency domain...
October 2015: American Journal of Surgery
https://www.readbyqxmd.com/read/26199407/the-therapeutic-value-of-atropine-for-critical-care-intubation
#15
REVIEW
Peter Jones
Recent studies of atropine during critical care intubation (CCI) have revealed that neonates frequently experience bradycardia, are infrequently affected by ventricular arrhythmias and conduction disturbances and deaths have not been reported in a series of studies. The indiscriminate use of atropine is unlikely to alter the outcome during neonatal CCI other than reducing the frequency of sinus tachycardia. In contrast, older children experience a similar frequency of bradycardia to neonates and are more frequently affected by ventricular arrhythmias and conduction disturbances...
January 2016: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/26168834/goal-directed-fluid-therapy-may-improve-hemodynamic-stability-of-parturient-with-hypertensive-disorders-of-pregnancy-under-combined-spinal-epidural-anesthesia-for-cesarean-delivery-and-the-well-being-of-newborns
#16
RANDOMIZED CONTROLLED TRIAL
Wei Xiao, Qing-Fang Duan, Wen-Ya Fu, Xin-Zuo Chi, Feng-Ying Wang, Da-Qing Ma, Tian-Long Wang, Lei Zhao
BACKGROUND: Hypotension induced by combined spinal epidural anesthesia in parturient with hypertensive disorders of pregnancy (HDP) can easily compromise blood supply to vital organs including uteroplacental perfusion and result in fetal distress. The aim of this study was to investigate whether the goal-directed fluid therapy (GDFT) with LiDCO rapid system can improve well-being of both HDP parturient and their babies. METHODS: Fifty-two stable HDP parturient scheduled for elective cesarean delivery were recruited...
July 20, 2015: Chinese Medical Journal
https://www.readbyqxmd.com/read/25926311/prediction-of-fluid-responsiveness-using-a-non-invasive-cardiac-output-monitor-in-children-undergoing-cardiac-surgery
#17
J-H Lee, H-J No, I-K Song, H-S Kim, C-S Kim, J-T Kim
BACKGROUND: This study evaluated the ability of a non-invasive cardiac output monitoring device (NICOM) to predict fluid responsiveness in paediatric patients undergoing cardiac surgery. METHODS: Children aged <5 yr undergoing congenital heart surgery were included. Once the sternum had been closed after repair of the congenital heart defect, 10 ml kg(-1) colloid solution was administered for volume expansion. Transoesophageal echocardiography (TOE) was performed to measure stroke volume (SV) and respiratory variation in aortic blood flow peak velocity (ΔV(peak)) before and after volume expansion...
July 2015: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/25919551/-effects-of-blood-transfusion-on-vital-signs-and-heart-function-in-preterm-infants-with-anemia
#18
Ying-Nian Ge, Xiao-Mei Tong, Yun-Feng Liu
OBJECTIVE: To explore the effects of blood transfusion on the vital signs and heart function in preterm infants with anemia. METHODS: A total of 40 anemic preterm infants with gestational age less than 34 weeks who accepted blood transfusion one week after birth were enrolled for a prospective cohort study. Left ventricular ejection fraction (LVEF), fractional shortening (FS), stroke volume (SV), and cardiac output (CO) were determined with portable ultrasonic equipment before blood transfusion and within 24 hours after blood transfusion...
April 2015: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/25895150/the-effect-of-milrinone-on-splanchnic-and-cerebral-perfusion-in-infants-with-congenital-heart-disease-prior-to-surgery-an-observational-study
#19
Maria Otilia Bianchi, Po-Yin Cheung, Ernest Phillipos, Abimael Aranha-Netto, Chloe Joynt
Despite the advancement in the postoperative care of neonates with congenital heart disease (CHD), there is little information on preoperative management of systemic and regional hemodynamics, which may be related to outcomes. We aimed to determine the preoperative effect of milrinone, a phosphodiesterase III inhibitor, on cardiac output and splanchnic and cerebral perfusion in neonates with CHD. Neonates with CHD requiring cardiac surgery were enrolled in a prospective, single-blinded study once a clinical decision of starting milrinone (0...
August 2015: Shock
https://www.readbyqxmd.com/read/25806562/prophylactic-milrinone-for-the-prevention-of-low-cardiac-output-syndrome-and-mortality-in-children-undergoing-surgery-for-congenital-heart-disease
#20
REVIEW
Barbara E U Burkhardt, Gerta Rücker, Brigitte Stiller
BACKGROUND: Children with congenital heart disease often undergo heart surgery at a young age. They are at risk for postoperative low cardiac output syndrome (LCOS) or death. Milrinone may be used to provide inotropic and vasodilatory support during the immediate postoperative period. OBJECTIVES: This review examines the effectiveness of prophylactic postoperative use of milrinone to prevent LCOS or death in children having undergone surgery for congenital heart disease...
2015: Cochrane Database of Systematic Reviews
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