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ADT and Exercise

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https://www.readbyqxmd.com/read/27897410/androgen-deprivation-causes-selective-deficits-in-the-biomechanical-leg-muscle-function-of-men-during-walking-a-prospective-case-control-study
#1
Ada S Cheung, Hans Gray, Anthony G Schache, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann
BACKGROUND: Although muscle mass declines with testosterone deficiency in men, previous studies of muscle function have not demonstrated consistent deficits, likely due to relatively insensitive methodology. Our objective was to determine the effects of testosterone deprivation on the biomechanical function of individual lower-limb muscles. METHODS: We conducted a 12-month prospective, observational case-control study of 34 men newly commencing androgen deprivation treatment (ADT) for prostate cancer and 29 age-matched prostate cancer controls...
August 2, 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27696495/quality-of-life-decrements-in-men-with-prostate-cancer-undergoing-androgen-deprivation-therapy
#2
Ada S Cheung, Casey de Rooy, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with decreased quality of life (QoL), controlled prospective studies are lacking. We aimed to assess QoL during ADT using two validated questionnaires and determine contributing factors. DESIGN: Prospective controlled study. PATIENTS: Sixty-three men with nonmetastatic prostate cancer newly commencing ADT (n = 34) and age- and radiotherapy-matched prostate cancer controls (n = 29)...
October 3, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27574584/integrating-diet-and-exercise-into-care-of-prostate-cancer-patients-on-androgen-deprivation-therapy
#3
REVIEW
Mark A Moyad, Robert U Newton, Ulf W Tunn, Damian Gruca
Improved diagnosis and treatment regimens have resulted in greater longevity for men with prostate cancer. This has led to an increase in both androgen deprivation therapy (ADT) use and duration of exposure, and therefore to its associated adverse effects, such as sexual dysfunction, osteoporosis, reduced muscle mass, increased fat mass, and increased incidence of cardiovascular disease and type 2 diabetes. Given that the adverse effects of ADT are systemic, often debilitating, and difficult to treat, efforts continue in the development of new strategies for long-term management of prostate cancer...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27534842/perpetuating-effects-of-androgen-deficiency-on-insulin-resistance
#4
J L Cameron, R Jain, M Rais, A E White, T M Beer, P Kievit, K Winters-Stone, I Messaoudi, O Varlamov
BACKGROUND/OBJECTIVES: Androgen deprivation therapy (ADT) is commonly used for treatment of prostate cancer, but is associated with side effects such as sarcopenia and insulin resistance. The role of lifestyle factors such as diet and exercise on insulin sensitivity and body composition in testosterone-deficient males is poorly understood. The aim of the present study was to examine the relationships between androgen status, diet, and insulin sensitivity. SUBJECTS/METHODS: Middle-aged (11-12-yo) intact and orchidectomized male rhesus macaques were maintained for two months on a standard chow diet, and then exposed for six months to a Western-style, high-fat/calorie-dense diet (WSD) followed by four months of caloric restriction (CR)...
August 18, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27357198/group-based-exercise-in-daily-clinical-practice-to-improve-physical-fitness-in-men-with-prostate-cancer-undergoing-androgen-deprivation-therapy-study-protocol
#5
Peter Østergren, Anne-Mette Ragle, Henrik Jakobsen, Tobias Wirenfeldt Klausen, Anders Vinther, Jens Sønksen
INTRODUCTION: Level 1 evidence supports the use of supervised exercise to mitigate the adverse effects of androgen deprivation therapy (ADT) in men with prostate cancer. The data, however, have been generated in controlled research settings and might not be transferable to daily clinical practice. This article describes the design of an ongoing prospective observational study to evaluate the potential benefits of exercise in daily clinical practice. METHODS AND ANALYSIS: Men diagnosed with prostate cancer starting or already receiving ADT at our facility are invited to participate in a 12-week exercise programme implemented as the standard of care...
2016: BMJ Open
https://www.readbyqxmd.com/read/27349496/a-review-of-clinical-effects-associated-with-metabolic-syndrome-and-exercise-in-prostate-cancer-patients
#6
REVIEW
J L Kiwata, T B Dorff, E T Schroeder, M E Gross, C M Dieli-Conwright
Androgen deprivation therapy (ADT), a primary treatment for locally advanced or metastatic prostate cancer, is associated with the adverse effects on numerous physiologic parameters, including alterations in cardiometabolic variables that overlap with components of the metabolic syndrome (MetS). As MetS is an established risk factor for cardiovascular mortality and treatment for prostate cancer has been associated with the development of MetS, interventions targeting cardiometabolic factors have been investigated in prostate cancer patients to attenuate the detrimental effects of ADT...
December 2016: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/27141453/what-do-urologists-think-patients-need-to-know-when-starting-on-androgen-deprivation-therapy-the-perspective-from-canada-versus-countries-with-lower-gross-domestic-product
#7
Irena Rot, Richard J Wassersug, Lauren M Walker
BACKGROUND: Androgen deprivation therapy (ADT) side effects are numerous and negatively impact prostate cancer patients' quality of life. There is considerable discrepancy though among Canadian urologists regarding what ADT side effects and side effect management strategies. Little is known about global differences in ADT patient education. METHODS: International respondents were recruited via online posting and at an international urology conference. Hypotheses suggest that economic and cultural differences influence patient education practices; therefore, international respondents were divided into 3 categories (high, medium, and low gross domestic product)...
April 2016: Translational Andrology and Urology
https://www.readbyqxmd.com/read/27112391/the-use-of-exercise-interventions-to-overcome-adverse-effects-of-androgen-deprivation-therapy
#8
REVIEW
Peter Busch Østergren, Caroline Kistorp, Finn Noe Bennedbæk, Jens Faber, Jens Sønksen, Mikkel Fode
Androgen deprivation therapy (ADT) induces severe hypogonadism and is associated with several adverse effects that negatively affect health and quality of life in patients with prostate cancer. ADT changes body composition characterized by an increase in fat mass and a reduction in muscle mass and strength. Insulin sensitivity is also diminished and population-based studies indicate an increased risk of diabetes mellitus and cardiovascular disease in men receiving ADT. Particularly the first 6 months of treatment seem to hold an additional risk of new cardiovascular events for patients with already existing cardiovascular disease...
June 2016: Nature Reviews. Urology
https://www.readbyqxmd.com/read/27098346/fitness-outcomes-from-a-randomised-controlled-trial-of-exercise-training-for-men-with-prostate-cancer-the-engage-study
#9
Cadeyrn J Gaskin, Steve F Fraser, Patrick J Owen, Melinda Craike, Liliana Orellana, Patricia M Livingston
PURPOSE: The main purpose of this study was to investigate the effects of a 12-week, clinician-referred, community-based exercise training program with supervised and unsupervised sessions for men with prostate cancer. The secondary purpose was to determine whether androgen deprivation therapy (ADT) modified responses to exercise training. METHODS: Secondary analysis was undertaken on data from a multicentre cluster randomised controlled trial in which 15 clinicians were randomly assigned to refer eligible patients to an exercise training intervention (n = 8) or to provide usual care (n = 7)...
December 2016: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/26916611/novel-physical-activity-interventions-for-older-patients-with-prostate-cancer-on-hormone-therapy-a-pilot-randomized-study
#10
Saleha Sajid, William Dale, Karen Mustian, Ashwin Kotwal, Charles Heckler, Michelle Porto, Chunkit Fung, Supriya G Mohile
BACKGROUND: Androgen deprivation therapy (ADT) can decrease the physical performance (PP) of older men with prostate cancer (PC). METHODS: We conducted a three-arm randomized pilot study (n=19) comparing a home-based walking and resistance intervention (EXCAP) and a technology-mediated walking and resistance intervention using Wii-Fit to a usual-care arm in men ≥70 years with PC receiving ADT. The intervention lasted for 6 weeks, with follow-up at 12 weeks. The primary pre-specified outcome was change in Short Physical Performance Battery (SPPB) score...
March 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/26816817/surgery-and-hormonal-treatment-for-prostate-cancer-and-sexual-function
#11
REVIEW
Katie Canalichio, Yasmeen Jaber, Run Wang
Prostate cancer (PC) is one of the most common cancers effecting men today. With earlier detection and improvements in available treatment modalities, there still remains significant morbidity associated with the treatment of PC. Male sexual health and erectile function are greatly impacted by these therapies and remain a concern to PC survivors. This article reviews the current literature on male sexual health following radical prostatectomy (RP) or androgen ablation therapy for PC. Each treatment modality affects male sexual function to an appreciable level, although certain patients have better outcomes if they have preoperative potency, are younger, or have nerve-sparing surgery...
April 2015: Translational Andrology and Urology
https://www.readbyqxmd.com/read/26766737/effects-of-a-lifestyle-intervention-on-endothelial-function-in-men-on-long-term-androgen-deprivation-therapy-for-prostate-cancer
#12
RANDOMIZED CONTROLLED TRIAL
Stephen E Gilbert, Garry A Tew, Caroline Fairhurst, Liam Bourke, John M Saxton, Edward M Winter, Derek J Rosario
BACKGROUND: Treatment of prostate cancer with androgen deprivation therapy (ADT) is associated with metabolic changes that have been linked to an increase in cardiovascular risk. METHODS: This randomised controlled trial investigated the effects of a 12-week lifestyle intervention that included supervised exercise training and dietary advice on markers of cardiovascular risk in 50 men on long-term ADT recruited to an on-going study investigating the effects of such a lifestyle intervention on quality of life...
February 16, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/26584972/exercise-improves-quality-of-life-in-androgen-deprivation-therapy-treated-prostate-cancer-systematic-review-of-randomised-controlled-trials
#13
REVIEW
Laisa Teleni, Raymond J Chan, Alexandre Chan, Elisabeth A Isenring, Ian Vela, Warrick J Inder, Alexandra L McCarthy
Men receiving androgen deprivation therapy (ADT) for prostate cancer (PCa) are likely to develop metabolic conditions such as diabetes, cardiovascular disease, abdominal obesity and osteoporosis. Other treatment-related side effects adversely influence quality of life (QoL) including vasomotor distress, depression, anxiety, mood swings, poor sleep quality and compromised sexual function. The objective of this study was to systematically review the nature and effects of dietary and exercise interventions on QoL, androgen deprivation symptoms and metabolic risk factors in men with PCa undergoing ADT...
February 2016: Endocrine-related Cancer
https://www.readbyqxmd.com/read/26563183/changes-in-physical-functioning-and-muscle-strength-in-men-receiving-androgen-deprivation-therapy-for-prostate-cancer-a-controlled-comparison
#14
Brian D Gonzalez, Heather S L Jim, Brent J Small, Steven K Sutton, Mayer N Fishman, Babu Zachariah, Randy V Heysek, Paul B Jacobsen
PURPOSE: The purpose of the study is to examine changes in muscle strength and self-reported physical functioning in men receiving androgen deprivation therapy (ADT) for prostate cancer compared to matched controls. METHODS: Prostate cancer patients scheduled to begin ADT (n = 62) were assessed within 20 days of starting ADT and 6 and 12 months later. Age and geographically matched prostate cancer controls treated with prostatectomy only (n = 86) were assessed at similar time intervals...
May 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/26372364/psychological-effects-of-androgen-deprivation-therapy-on-men-with-prostate-cancer-and-their-partners
#15
REVIEW
Kristine A Donovan, Lauren M Walker, Richard J Wassersug, Lora M A Thompson, John W Robinson
The clinical benefits of androgen-deprivation therapy (ADT) for men with prostate cancer (PC) have been well documented and include living free from the symptoms of metastases for longer periods and improved quality of life. However, ADT comes with a host of its own serious side effects. There is considerable evidence of the adverse cardiovascular, metabolic, and musculoskeletal effects of ADT. Far less has been written about the psychological effects of ADT. This review highlights several adverse psychological effects of ADT...
December 15, 2015: Cancer
https://www.readbyqxmd.com/read/26148319/a-qualitative-study-exploring-the-perceptions-of-sedentary-behavior-in-prostate-cancer-survivors-receiving-androgen-deprivation-therapy
#16
Linda Trinh, Kelly P Arbour-Nicitopoulos, Catherine M Sabiston, Shabbir M Alibhai, Jennifer M Jones, Scott R Berry, Andrew Loblaw, Guy E Faulkner
PURPOSE/OBJECTIVES: To describe and understand the perceptions of sedentary behavior (SED) and the interests and preferences for a SED intervention of men on androgen-deprivation therapy (ADT) within a two-phase (formative and intervention research) feasibility study. RESEARCH APPROACH: Qualitative, descriptive. SETTING: Princess Margaret Cancer Centre and Odette Cancer Centre, both in Toronto, Ontario, Canada. PARTICIPANTS: 27 men on ADT...
July 2015: Oncology Nursing Forum
https://www.readbyqxmd.com/read/26148314/resistance-exercise-reduces-body-fat-and-insulin-during-androgen-deprivation-therapy-for-prostate-cancer
#17
RANDOMIZED CONTROLLED TRIAL
Kerri M Winters-Stone, Nathan Dieckmann, Gianni F Maddalozzo, Jill A Bennett, Christopher W Ryan, Tomasz M Beer
PURPOSE/OBJECTIVES: To determine whether exercise could reduce biomarkers of cancer progression in prostate cancer survivors (PCSs) on androgen-deprivation therapy (ADT). DESIGN: Randomized, controlled trial. SETTING: Oregon Health and Science University School of Nursing. SAMPLE: 51 PCSs randomized to one year of resistance and impact training or a stretching control group. METHODS: The authors investigated changes in body composition and cancer-related biomarkers, and the influence of age and fat loss on changes in biomarkers...
July 2015: Oncology Nursing Forum
https://www.readbyqxmd.com/read/26003426/the-effects-of-resistance-exercise-on-physical-performance-and-health-related-quality-of-life-in-prostate-cancer-patients-a-systematic-review
#18
REVIEW
T Hasenoehrl, M Keilani, T Sedghi Komanadj, M Mickel, M Margreiter, M Marhold, R Crevenna
PURPOSE: Physical exercise has been shown to be an effective, safe, and quite inexpensive method to reduce cardiovascular and metabolic risk factors and is currently in the process of establishing its relevance for cancer specific morbidity and mortality. The aim of this systematic review was to focus on specific effects of resistance exercise (RE) in the adjuvant therapy and rehabilitation of prostate cancer patients (PCaPs) receiving or having received androgen deprivation therapy (ADT)...
August 2015: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/25993223/sexual-healing-in-patients-with-prostate-cancer-on-hormone-therapy
#19
REVIEW
Leslie R Schover
Since prostate cancer becomes more common with age, at least one-third of men have sexual problems at diagnosis. All localized treatments for prostate cancer greatly increase the prevalence of sexual dysfunction, which include loss of desire, erectile dysfunction, and changes in orgasm. Even men on active surveillance have a higher rate of problems than matched peers without prostate cancer. However, men given androgen deprivation therapy (ADT) have the worst rates of sexual dysfunction. Even after 3 to 4 months of ADT, men's desire for sex is decreased and irreversible damage may occur to the erectile tissue in the penis...
2015: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/25927504/effects-of-strength-training-on-body-composition-physical-functioning-and-quality-of-life-in-prostate-cancer-patients-during-androgen-deprivation-therapy
#20
RANDOMIZED CONTROLLED TRIAL
Tormod S Nilsen, Truls Raastad, Eva Skovlund, Kerry S Courneya, Carl W Langberg, Wolfgang Lilleby, Sophie D Fosså, Lene Thorsen
BACKGROUND: Androgen deprivation therapy (ADT) increases survival rates in prostate cancer (PCa) patients with locally advanced disease, but is associated with side effects that may impair daily function. Strength training may counteract several side effects of ADT, such as changes in body composition and physical functioning, which in turn may affect health-related quality of life (HRQOL). However, additional randomised controlled trials are needed to expand this knowledge. MATERIAL AND METHODS: Fifty-eight PCa patients on ADT were randomised to either 16 weeks of high-load strength training (n = 28) or usual care (n = 30)...
November 2015: Acta Oncologica
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