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ADT and Exercise

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https://www.readbyqxmd.com/read/29194928/clinical-pathway-improves-implementation-of-evidence-based-strategies-for-the-management-of-androgen-deprivation-therapy-induced-side-effects-in-prostate-cancer-patients
#1
Renée Bultijnck, Inge Van de Caveye, Elke Rammant, Sofie Everaert, Nicolaas Lumen, Karel Decaestecker, Valérie Fonteyne, Benedicte Deforche, Piet Ost
OBJECTIVES: To assess the effects of a prostate cancer (PCa) clinical pathway on the implementation of evidence-based strategies for the management of ADT-induced side effects. SUBJECTS/PATIENTS AND METHODS: A clinical pathway was introduced at hospital-level in 2015. The pathway consists out of evidence-based strategies for the management of ADT-induced side effects. All PCa patients receiving ADT for >6 months were eligible to enter the clinical pathway. Data of recommended evidence-based strategies were retrospectively extracted from electronic health records of all eligible patients in the year before (2014) and the year of implementation of the pathway (2015)...
December 1, 2017: BJU International
https://www.readbyqxmd.com/read/29091915/affect-during-incremental-exercise-the-role-of-inhibitory-cognition-autonomic-cardiac-function-and-cerebral-oxygenation
#2
Weslley Quirino Alves da Silva, Eduardo Bodnariuc Fontes, Rodrigo Menezes Forti, Zayonara Larissa Lima, Daniel Gomes da Silva Machado, Andréa Camaz Deslandes, Erika Hussey, Nathan Ward, Rickson Coelho Mesquita, Alexandre Hideki Okano, Hassan Mohamed Elsangedy
BACKGROUND: Pleasure is a key factor for physical activity behavior in sedentary individuals. Inhibitory cognitive control may play an important role in pleasure perception while exercising, especially at high intensities. In addition, separate work suggests that autonomic regulation and cerebral hemodynamics influence the affective and cognitive responses during exercise. PURPOSE: We investigated the effects of exercise intensity on affect, inhibitory control, cardiac autonomic function, and prefrontal cortex (PFC) oxygenation...
2017: PloS One
https://www.readbyqxmd.com/read/28974267/efficacy-of-a-multi-component-exercise-programme-and-nutritional-supplementation-on-musculoskeletal-health-in-men-treated-with-androgen-deprivation-therapy-for-prostate-cancer-impact-study-protocol-of-a-randomised-controlled-trial
#3
Patrick J Owen, Robin M Daly, Patricia M Livingston, Niamh L Mundell, Jack Dalla Via, Jeremy L Millar, Steve F Fraser
BACKGROUND: Prostate cancer is the most commonly diagnosed cancer in men in developed countries. Androgen deprivation therapy (ADT) is a systemic treatment shown to increase survival in selected patients with prostate cancer. The use of ADT continues to increase for all stages and grades of prostate cancer despite known treatment-induced adverse effects. The primary aim of this study is to examine the efficacy of a targeted, multi-component resistance and impact-loading exercise programme together with a daily protein-, calcium- and vitamin D-enriched supplement on bone health in men treated with ADT for prostate cancer...
October 3, 2017: Trials
https://www.readbyqxmd.com/read/28872752/time-on-androgen-deprivation-therapy-and-adaptations-to-exercise-secondary-analysis-from-a-12-month-randomized-controlled-trial-in-men-with-prostate-cancer
#4
Dennis R Taaffe, Laurien M Buffart, Robert U Newton, Nigel Spry, James Denham, David Joseph, David Lamb, Suzanne K Chambers, Daniel A Galvão
OBJECTIVES: To explore if duration of previous exposure to androgen deprivation therapy (ADT) in men with prostate cancer (PCa) undertaking a year-long exercise programme moderates the exercise response with regard to body composition and muscle performance, and also to explore the moderator effects of baseline testosterone, time since ADT, and baseline value of the outcome. PATIENTS AND METHODS: In a multicentre randomized controlled trial, 100 men who had previously undergone either 6 months (short-term) or 18 months (long-term) of ADT in combination with radiotherapy, as part of the TROG 03...
September 5, 2017: BJU International
https://www.readbyqxmd.com/read/28731882/the-effect-on-bone-outcomes-of-home-based-exercise-intervention-for-prostate-cancer-survivors-receiving-androgen-deprivation-therapy-a-pilot-randomized-controlled-trial
#5
Soo Hyun Kim, Do Hwan Seong, Sang Min Yoon, Young Deuk Choi, Eunju Choi, Youngkyu Song, Hosook Song
BACKGROUND: Cancer treatment-induced bone loss has important long-term effects in prostate cancer survivors (PCSs) receiving androgen deprivation therapy (ADT), but little is known about preventive interventions. OBJECTIVE: The aim of this study was to examine the feasibility and preliminary effectiveness of a 6-month home-based exercise intervention in PCSs. METHODS: In this pilot, randomized controlled trial, 51 men (mean age, 70.8 years) were randomized to a 6-month home-based exercise intervention for preventing osteoporosis group (n = 26) or an exercise placebo intervention of stretching exercise group (n = 25)...
July 20, 2017: Cancer Nursing
https://www.readbyqxmd.com/read/28723517/practice-patterns-compared-with-evidence-based-strategies-for-the-management-of-androgen-deprivation-therapy-induced-side-effects-in-prostate-cancer-patients-results-of-a-european-web-based-survey
#6
Renée Bultijnck, Cristian Surcel, Guillaume Ploussard, Alberto Briganti, Pieter De Visschere, Jurgen Fütterer, Pirus Ghadjar, Gianluca Giannarini, Hendrik Isbarn, Christophe Massard, Prasanna Sooriakumaran, Massimo Valerio, Roderick van den Bergh, Piet Ost
BACKGROUND: Evidence-based recommendations are available for the management of androgen deprivation therapy (ADT)-induced side effects; however, there are no data on the implementation of the recommendations into daily practice patterns. OBJECTIVE: To compare practice patterns in the management of ADT-induced side effects with evidence-based strategies. DESIGN, SETTING, AND PARTICIPANTS: A European Web-based survey was conducted from January 16, 2015, to June 24, 2015...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28698349/a-pilot-randomised-controlled-trial-of-a-periodised-resistance-training-and-protein-supplementation-intervention-in-prostate-cancer-survivors-on-androgen-deprivation-therapy
#7
Jacqueline L Kiwata, Tanya B Dorff, E Todd Schroeder, George J Salem, Christianne J Lane, Judd C Rice, Mitchell E Gross, Christina M Dieli-Conwright
INTRODUCTION: Prostate cancer survivors (PCS) receiving androgen deprivation therapy (ADT) experience deleterious side effects such as unfavourable changes in cardiometabolic factors that lead to sarcopenic obesity and metabolic syndrome (MetS). While loss of lean body mass (LBM) compromises muscular strength and quality of life, MetS increases the risk of cardiovascular disease and may influence cancer recurrence. Exercise can improve LBM and strength, and may serve as an alternative to the pharmacological management of MetS in PCS on ADT...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28682886/exercise-overcome-adverse-effects-among-prostate-cancer-patients-receiving-androgen-deprivation-therapy-an-update-meta-analysis
#8
REVIEW
Gao Yunfeng, He Weiyang, He Xueyang, Huang Yilong, Gou Xin
BACKGROUND: Prostate cancer (PCa) patients initiating androgen deprivation therapy (ADT) are suffering from adverse effects; exercise has been proposed as a treatment to relieve adverse effects of ADT, available meta-analysis has proved exercise improves quality of life, and therapy caused fatigue; recently, some high-quality trials have been conducted in order to get more assessment; we conduct an updated meta-analysis to evaluate feasibility that exercise relieves adverse effects in PCa patients initiating ADT...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28557849/monitoring-resistance-exercise-intensity-via-rpe-in-previously-untrained-patients-with-prostate-cancer-undergoing-androgen-deprivation-therapy
#9
C M Fairman, R L LaFountain, A R Lucas, B C Focht
Exercise has been shown to be safe and effective for prostate cancer (PrCa) patients. The monitoring of resistance exercise (RE) intensity is an emerging area of interest in RE prescription. Rating of perceived exertion (RPE) is one of the most commonly used methods, but has not yet been validated in this population. Thus, the purpose of this study was to examine the relationship between RPE and RE intensity in PrCa. Data for this study were abstracted from baseline upper and lower body strength assessments from two previous trials (IDEA-P; Livestrong) in our laboratory investigating functional outcomes in PrCa patients undergoing androgen deprivation therapy (ADT)...
May 23, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28359098/attenuation-of-resting-but-not-load-mediated-protein-synthesis-in-prostate-cancer-patients-on-androgen-deprivation
#10
Erik D Hanson, André R Nelson, Daniel W D West, John A Violet, Lannie O'Keefe, Stuart M Phillips, Alan Hayes
Context: Androgen deprivation therapy (ADT) is a common prostate cancer (PCa) treatment but results in muscular atrophy. Periodic increases in muscle protein synthesis (MPS) that occur after resistance exercise or protein intake may ameliorate this muscle loss, but the impact of these anabolic stimuli during ADT is unclear. Objective: To determine the acute MPS response to whey protein supplementation with and without resistance exercise during ADT. Design: Acute response in PCa patients vs age-matched controls (CON)...
March 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28319589/exercise-improves-v%C3%AB-o2max-and-body-composition-in-androgen-deprivation-therapy-treated-prostate-cancer-patients
#11
Bradley A Wall, Daniel A GALVãO, Naeem Fatehee, Dennis R Taaffe, Nigel Spry, David Joseph, Jeffrey J Hebert, Robert U Newton
INTRODUCTION: Prostate cancer is the most common cancer in men, and patients treated with androgen deprivation therapy (ADT) experience unfavorable changes in body composition and associated metabolic complications, which can increase the risk of cardiovascular disease. We examined the effect of a 6-month program of aerobic and resistance exercise aimed at improving body composition and cardiorespiratory health in this population. METHODS: Ninety-seven men (43-90 yr) with localized prostate cancer receiving ADT were randomized to either exercise (EX, n = 50) or usual care (CON, n = 47)...
August 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28249801/effects-of-different-exercise-modalities-on-fatigue-in-prostate-cancer-patients-undergoing-androgen-deprivation-therapy-a-year-long-randomised-controlled-trial
#12
Dennis R Taaffe, Robert U Newton, Nigel Spry, David Joseph, Suzanne K Chambers, Robert A Gardiner, Brad A Wall, Prue Cormie, Kate A Bolam, Daniel A Galvão
BACKGROUND: Physical exercise mitigates fatigue during androgen deprivation therapy (ADT); however, the effects of different exercise prescriptions are unknown. OBJECTIVES: To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT. DESIGN, SETTING, AND PARTICIPANTS: Between 2009 and 2012, 163 prostate cancer patients aged 43-90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading+resistance training; ILRT; n=58), the cardiovascular and muscular systems (aerobic+resistance training; ART; n=54), or to usual care/delayed exercise (DEL; n=51) for 12 mo across university-affiliated exercise clinics in Australia...
August 2017: European Urology
https://www.readbyqxmd.com/read/28209634/cognitive-decline-in-prostate-cancer-patients-undergoing-adt
#13
Niamh Liana Mundell, Robin M Daly, Helen Macpherson, Steve F Fraser
Androgen deprivation therapy (ADT) is an effective and widely prescribed treatment for prostate cancer (PCa), but it is associated with multiple treatment induced adverse effects that impact on various musculoskeletal and cardiometabolic health outcomes. Emerging research has shown that ADT is also associated with cognitive impairment, which has been linked to a loss of independence, increased falls and fracture risk and greater use of medical services. The aim of this review is to outline the evidence related to the effect of ADT use on cognitive function, and propose a role for exercise training as part of usual care to prevent and/or manage cognitive impairments for PCa survivors on ADT...
February 16, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28117386/lifestyle-guidelines-for-managing-adverse-effects-on-bone-health-and-body-composition-in-men-treated-with-androgen-deprivation-therapy-for-prostate-cancer-an-update
#14
REVIEW
P J Owen, R M Daly, P M Livingston, S F Fraser
BACKGROUND: Men treated with androgen deprivation therapy (ADT) for prostate cancer are prone to multiple treatment-induced adverse effects, particularly with regard to a deterioration in bone health and altered body composition including decreased lean tissue mass and increased fat mass. These alterations may partially explain the marked increased risk in osteoporosis, falls, fracture and cardiometabolic risk that has been observed in this population. METHODS: A review was conducted that assessed standard clinical guidelines for the management of ADT-induced adverse effects on bone health and body composition in men with prostate cancer...
June 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28110898/american-brachytherapy-society-task-group-report-use-of-androgen-deprivation-therapy-with-prostate-brachytherapy-a-systematic-literature-review
#15
REVIEW
M Keyes, G Merrick, S J Frank, P Grimm, M J Zelefsky
PURPOSE: Prostate brachytherapy (PB) has well-documented excellent long-term outcomes in all risk groups. There are significant uncertainties regarding the role of androgen deprivation therapy (ADT) with brachytherapy. The purpose of this report was to review systemically the published literature and summarize present knowledge regarding the impact of ADT on biochemical progression-free survival (bPFS), cause-specific survival (CSS), and overall survival (OS). METHODS AND MATERIALS: A literature search was conducted in Medline and Embase covering the years 1996-2016...
January 16, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28075422/inflammation-cardiometabolic-markers-and-functional-changes-in-men-with-prostate-cancer-a-randomized-controlled-trial-of-a-12%C3%A2-month-exercise-program
#16
RANDOMIZED CONTROLLED TRIAL
Katarzyna Hojan, Eliza Kwiatkowska-Borowczyk, Ewa Leporowska, Piotr Milecki
INTRODUCTION Previous studies have shown that physical exercise in cancer patients during radiation therapy (RT) and androgen deprivation therapy (ADT) improves cardiac fitness and quality of life (QoL), as well as reduces fatigue, but it is still not entirely known how it affects inflammation or metabolic factors and what its consequences are in patients with prostate cancer (PCa). OBJECTIVES The aim of the study was to assess the effect of a 12‑month physical exercise program on inflammatory and cardiometabolic parameters, as well as on functional status in patients with PCa undergoing RT and ADT...
January 10, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/27897410/androgen-deprivation-causes-selective-deficits-in-the-biomechanical-leg-muscle-function-of-men-during-walking-a-prospective-case-control-study
#17
Ada S Cheung, Hans Gray, Anthony G Schache, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Marcus G Pandy, Mathis Grossmann
BACKGROUND: Although muscle mass declines with testosterone deficiency in men, previous studies of muscle function have not demonstrated consistent deficits, likely due to relatively insensitive methodology. Our objective was to determine the effects of testosterone deprivation on the biomechanical function of individual lower-limb muscles. METHODS: We conducted a 12-month prospective, observational case-control study of 34 men newly commencing androgen deprivation treatment (ADT) for prostate cancer and 29 age-matched prostate cancer controls...
February 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27696495/quality-of-life-decrements-in-men-with-prostate-cancer-undergoing-androgen-deprivation-therapy
#18
Ada S Cheung, Casey de Rooy, Rudolf Hoermann, Daryl Lim Joon, Jeffrey D Zajac, Mathis Grossmann
OBJECTIVE: While androgen deprivation therapy (ADT) has been associated with decreased quality of life (QoL), controlled prospective studies are lacking. We aimed to assess QoL during ADT using two validated questionnaires and determine contributing factors. DESIGN: Prospective controlled study. PATIENTS: Sixty-three men with nonmetastatic prostate cancer newly commencing ADT (n = 34) and age- and radiotherapy-matched prostate cancer controls (n = 29)...
March 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/27574584/integrating-diet-and-exercise-into-care-of-prostate-cancer-patients-on-androgen-deprivation-therapy
#19
REVIEW
Mark A Moyad, Robert U Newton, Ulf W Tunn, Damian Gruca
Improved diagnosis and treatment regimens have resulted in greater longevity for men with prostate cancer. This has led to an increase in both androgen deprivation therapy (ADT) use and duration of exposure, and therefore to its associated adverse effects, such as sexual dysfunction, osteoporosis, reduced muscle mass, increased fat mass, and increased incidence of cardiovascular disease and type 2 diabetes. Given that the adverse effects of ADT are systemic, often debilitating, and difficult to treat, efforts continue in the development of new strategies for long-term management of prostate cancer...
2016: Research and Reports in Urology
https://www.readbyqxmd.com/read/27534842/perpetuating-effects-of-androgen-deficiency-on-insulin-resistance
#20
J L Cameron, R Jain, M Rais, A E White, T M Beer, P Kievit, K Winters-Stone, I Messaoudi, O Varlamov
BACKGROUND/OBJECTIVES: Androgen deprivation therapy (ADT) is commonly used for treatment of prostate cancer but is associated with side effects, such as sarcopenia and insulin resistance. The role of lifestyle factors such as diet and exercise on insulin sensitivity and body composition in testosterone-deficient males is poorly understood. The aim of the present study was to examine the relationships between androgen status, diet and insulin sensitivity. SUBJECTS/METHODS: Middle-aged (11-12 years old) intact and orchidectomized male rhesus macaques were maintained for 2 months on a standard chow diet and then exposed for 6 months to a Western-style, high-fat/calorie-dense diet (WSD) followed by 4 months of caloric restriction (CR)...
December 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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