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https://www.readbyqxmd.com/read/28438442/molecular-identification-of-enterocytozoon-bieneusi-and-encephalitozoon-spp-in-immunodeficient-patients-in-ahvaz-southwest-of-iran
#1
Mehdi Tavalla, Masoumeh Mardani-Kateki, Rahman Abdizadeh, Roohangiz Nashibi, Abdollah Rafie, Shahram Khademvatan
Microsporidia are often considered as an opportunistic infection in patients with impaired immune systems such as transplant recipients and patients with acquired immune deficiency syndrome (AIDS). Due to the increasing prevalence of parasitic infections and immunodeficiency diseases; the aim of the study is to evaluate molecular identification of Enterocytozoon bieneusi and Encephalitozoon spp. in immunodeficient patients in Ahvaz, southwest of Iran. At first, 310 stool samples were collected from patients with immunodeficiency...
April 21, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28426751/the-role-of-microsporidian-polar-tube-protein-4-ptp4-in-host-cell-infection
#2
Bing Han, Valérie Polonais, Tatsuki Sugi, Rama Yakubu, Peter M Takvorian, Ann Cali, Keith Maier, Mengxian Long, Matthew Levy, Herbert B Tanowitz, Guoqing Pan, Frédéric Delbac, Zeyang Zhou, Louis M Weiss
Microsporidia have been identified as pathogens that have important effects on our health, food security and economy. A key to the success of these obligate intracellular pathogens is their unique invasion organelle, the polar tube, which delivers the nucleus containing sporoplasm into host cells during invasion. Due to the size of the polar tube, the rapidity of polar tube discharge and sporoplasm passage, and the absence of genetic techniques for the manipulation of microsporidia, study of this organelle has been difficult and there is relatively little known regarding polar tube formation and the function of the proteins making up this structure...
April 20, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28339881/genetic-aspects-and-environmental-sources-of-microsporidia-that-infect-the-human-gastrointestinal-tract
#3
Martin F Heyworth
Enterocytozoon bieneusi and Encephalitozoon intestinalis are microsporidia that infect the human gastrointestinal (GI) tract. Each of these microsporidia has been shown to infect various non-human hosts (mammalian and avian), raising the possibility of inter-species transmission, for example, from such hosts to human subjects via waterborne dispersal of microsporidian spores. During the past two decades, genome sequencing has delineated more than 90 genotypes of Ent. bieneusi, and has led to the conclusion that not all the genotypes of this organism infect human subjects...
February 27, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28338834/comparative-genomics-of-microsporidian-genomes-reveals-a-minimal-non-coding-rna-set-and-new-insights-for-transcription-in-minimal-eukaryotic-genomes
#4
Abdel Belkorchia, Jean-François Pombert, Valérie Polonais, Nicolas Parisot, Frédéric Delbac, Jean-François Brugère, Pierre Peyret, Christine Gaspin, Eric Peyretaillade
Microsporidia are ubiquitous intracellular pathogens whose opportunistic nature led to their increased recognition with the rise of the AIDS pandemic. As the RNA world was largely unexplored in this parasitic lineage, we developed a dedicated in silico methodology to carry out exhaustive identification of ncRNAs across the Encephalitozoon and Nosema genera. Thus, the previously missing U1 small nuclear RNA (snRNA) and small nucleolar RNAs (snoRNAs) targeting only the LSU rRNA were highlighted and were further validated using 5' and 3'RACE-PCR experiments...
February 28, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28321967/comparative-analysis-of-the-proteins-with-tandem-repeats-from-8-microsporidia-and-characterization-of-a-novel-endospore-wall-protein-colocalizing-with-polar-tube-from-nosema-bombycis
#5
Ying Wang, Huixia Geng, Xiaoqun Dang, Heng Xiang, Tian Li, Guoqing Pan, Zeyang Zhou
As a common feature of eukaryotic proteins, tandem amino acid repeat has been studied extensively in both animal and plant proteins. Here, a comparative analysis focusing on the proteins having tandem repeats was conducted in 8 microsporidia, including four mammal-infecting microsporidia (Encephalitozoon cuniculi, Encephalitozoon intestinalis, Encephalitozoon hellem and Encephalitozoon bieneusi) and four insect-infecting microsporidia (Nosema apis, Nosema ceranae, Vavraia culicis and Nosema bombycis). We found that the proteins with tandem repeats were abundant in these species...
March 21, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28303005/ligand-co-crystallization-of-aminoacyl-trna-synthetases-from-infectious-disease-organisms
#6
Spencer O Moen, Thomas E Edwards, David M Dranow, Matthew C Clifton, Banumathi Sankaran, Wesley C Van Voorhis, Amit Sharma, Colin Manoil, Bart L Staker, Peter J Myler, Donald D Lorimer
Aminoacyl-tRNA synthetases (aaRSs) charge tRNAs with their cognate amino acid, an essential precursor step to loading of charged tRNAs onto the ribosome and addition of the amino acid to the growing polypeptide chain during protein synthesis. Because of this important biological function, aminoacyl-tRNA synthetases have been the focus of anti-infective drug development efforts and two aaRS inhibitors have been approved as drugs. Several researchers in the scientific community requested aminoacyl-tRNA synthetases to be targeted in the Seattle Structural Genomics Center for Infectious Disease (SSGCID) structure determination pipeline...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220747/three-cases-of-neurologic-syndrome-caused-by-donor-derived-microsporidiosis
#7
Rachel M Smith, Atis Muehlenbachs, Joanna Schaenmann, Sanjiv Baxi, Sophia Koo, Dianna Blau, Peter Chin-Hong, Anna R Thorner, Matthew J Kuehnert, Kristina Wheeler, Alexis Liakos, Jonathan W Jackson, Theresa Benedict, Alexandre J da Silva, Jana M Ritter, Dominique Rollin, Maureen Metcalfe, Cynthia S Goldsmith, Govinda S Visvesvara, Sridhar V Basavaraju, Sherif Zaki
In April 2014, a kidney transplant recipient in the United States experienced headache, diplopia, and confusion, followed by neurologic decline and death. An investigation to evaluate the possibility of donor-derived infection determined that 3 patients had received 4 organs (kidney, liver, heart/kidney) from the same donor. The liver recipient experienced tremor and gait instability; the heart/kidney and contralateral kidney recipients were hospitalized with encephalitis. None experienced gastrointestinal symptoms...
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28205456/histochemical-study-of-encephalitozoon-cuniculi-spores-in-the-kidneys-of-naturally-infected-new-zealand-rabbits
#8
Luis E Rodríguez-Tovar, Alejandra Villarreal-Marroquín, Alicia M Nevárez-Garza, Uziel Castillo-Velázquez, Heidi G Rodríguez-Ramírez, Magda C Navarro-Soto, Juan J Zárate-Ramos, Gustavo Hernández-Vidal, Armando Trejo-Chávez
Encephalitozoon cuniculi is an important microsporidian pathogen that is considered an emergent, zoonotic, and opportunistic. It infects both domestic and laboratory rabbits, generating severe chronic interstitial and granulomatous nephritis with fibrosis and granulomatous encephalitis. Encephalitozoonosis is diagnosed in paraffin-embedded sections by examining the spores in the host tissues. The spores are difficult to observe when the samples are stained with hematoxylin and eosin (H&E), particularly when there is an inflammatory reaction and tissue damage...
February 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28199765/survey-for-zoonotic-microsporidian-pathogens-in-wild-living-urban-rooks-corvus-frugilegus
#9
Agnieszka Perec-Matysiak, Maria Wesołowska, Kinga Leśniańska, Katarzyna Buńkowska-Gawlik, Joanna Hildebrand, Marta Kicia
Microsporidia are opportunistic pathogens in nature infecting all animal phyla. There is a potential risk of microsporidian spores transmission from urban rooks inhabiting some metropolitan cities to people through casual interactions. The aim of this study was to identify microsporidia species in the droppings of rooks in Wroclaw, Poland. A total of 15 collective sets of droppings were examined using nested-PCR method. Amplification of ITS rRNA gene revealed the presence of Enterocytozoon bieneusi D, Peru 6 and Encephalitozoon hellem 1A genotypes...
February 15, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28131379/encephalitozoon-cuniculi-in-rabbits-serological-screening-and-histopathological-findings
#10
Giovanni Maestrini, Emanuele Ricci, Carlo Cantile, Riccardo Mannella, Francesca Mancianti, Gisella Paci, Carlo D'Ascenzi, Stefania Perrucci
Serological prevalence of E. cuniculi infection was assessed in 183 rabbits from central Italy. In seropositive deceased rabbits, histopathological lesions were also evaluated. Sera from 118 rabbits from 6 intensive farms, 10 rabbits from 6 family farms, 16 rabbits from a zoo, 30 rabbits from 5 research laboratories and 9 pet rabbits from 9 different owners, were tested by an enzyme-linked immunosorbent assay. Data were statistically analysed. Tissue samples from brain and kidney of 10 deceased rabbits were formalin-fixed and subsequently analysed by histopathology and immunohistochemistry...
February 2017: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/28115231/molecular-detection-and-species-identification-of-enterocytozoon-bieneusi-isolated-from-immunocompetent-orang-asli-in-malaysia
#11
Azah Ashikin, Hesham M Al-Mekhlafi, Norhayati Moktar, Tengku Shahrul Anuar
Most studies of opportunistic infections focus on immunocompromised patients. However, there is a lack of information on microsporidiosis in healthy people (immunocompetent) worldwide. This study aimed to detect and identify microsporidia species in immunocompetent Orang Asli living in Pahang, Malaysia. Orang Asli is a collective term for a group of indigenous people that usually reside in the interior regions of Peninsular Malaysia. They comprise about 0.7% of the total population in Malaysia and 76% of them lived below the poverty line i...
April 2017: Parasitology International
https://www.readbyqxmd.com/read/27966020/application-of-western-blot-analysis-for-the-diagnosis-of-encephalitozoon-cuniculi-infection-in-rabbits-example-of-a-quantitative-approach
#12
Guillaume Desoubeaux, Ana Pantin, Roman Peschke, Anja Joachim, Carolyn Cray
Diagnosis of Encephalitozoon cuniculi infection in rabbits remains a major veterinary issue. ELISA or immunofluorescence assays are the current reference standards of serological tests. However, these conventional techniques suffer from a lack of accuracy for distinguishing active from past infections, as a positive serostatus is common in clinically normal rabbits. In this study, we assessed the diagnostic performance of Western blot (WB) to detect both anti-E. cuniculi immunoglobulin G (IgG) and immunoglobulin M (IgM) in comparison with ELISA and to address the intensity of the immune response through a quantitative approach...
February 2017: Parasitology Research
https://www.readbyqxmd.com/read/27905620/-the-water-supply-of-a-pediatric-hospital-as-a-possible-source-of-an-outbreak-of-diarrhea-due-to-microsporidium-spp-in-immunocompromised-patients
#13
Paulina Coria, Claudia Urízar, Andrea Alba, Isabel Noemí, Anita Pino, José Luis Cerva
INTRODUCTION: The hospital water supply is a reservoir of a variety of potentially pathogenic microorganisms that can particularly affect children and immunocompromised patients. Potentially pathogenic Microsporidium spp. have been identified in water. Microsporidiosis is an emerging parasitic and opportunistic infection in immunocompromised patients. OBJECTIVE AND METHOD: to describe an outbreak of nosocomial diarrhea due to Microsporidium, species Encephalitozoon intestinalis...
August 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27822234/prevention-and-treatment-of-encephalitozoon-cuniculi-infection-in-immunosuppressed-rabbits-with-fenbendazole
#14
S S Abu-Akkada, S S Oda
This study was conducted to evaluate the efficacy of oral administration of fenbendazole (20 mg/kg body weight) prior to and after experimental infection of immunosuppressed rabbits with Encephalitozoon cuniculi. A total of thirty rabbits were divided into five groups: NN (non-immunosuppressed; non-infected), IN (immunosuppressed; non-infected), IPI (immunosuppressed; protected-infected), ITI (immunosuppressed; treated-infected), and II (immunosuppressed; infected) groups. Fenbendazole was administered as a prophylactic for seven successive days before infection with E...
2016: Iranian journal of veterinary research
https://www.readbyqxmd.com/read/27707513/b-1-cell-decreases-susceptibility-to-encephalitozoonosis-in-mice
#15
Lidiana Flora Vidoto da Costa, Anuska Marcelino Alvares-Saraiva, Paulo Ricardo Dell'Armelina Rocha, Diva Denelle Spadacci-Morena, Elizabeth Cristina Perez, Mario Mariano, Maria Anete Lallo
Encephalitozoon cuniculi is an opportunist intracellular pathogen of mammals. The adaptive immune response is essential to eliminate E. cuniculi, but evidence is mounting that the response initiated by the innate immune response may ultimately define whether or not the parasite can survive. B-1 cells may act as antigen-presenting cells or differentiate into phagocytes, playing different roles in many infection models. However, the role of these cells in the dynamics of Encephalitozoon sp. infections is still unknown...
February 2017: Immunobiology
https://www.readbyqxmd.com/read/27598992/the-genome-of-nosema-sp-isolate-ynpr-a-comparative-analysis-of-genome-evolution-within-the-nosema-vairimorpha-clade
#16
Jinshan Xu, Qiang He, Zhenggang Ma, Tian Li, Xiaoyan Zhang, Bettina A Debrunner-Vossbrinck, Zeyang Zhou, Charles R Vossbrinck
The microsporidian parasite designated here as Nosema sp. Isolate YNPr was isolated from the cabbage butterfly Pieris rapae collected in Honghe Prefecture, Yunnan Province, China. The genome was sequenced by Illumina sequencing and compared to those of two related members of the Nosema/Vairimorpha clade, Nosema ceranae and Nosema apis. Based upon assembly statistics, the Nosema sp. YNPr genome is 3.36 x 106bp with a G+C content of 23.18% and 2,075 protein coding sequences. An "ACCCTT" motif is present approximately 50-bp upstream of the start codon, as reported from other members of the clade and from Encephalitozoon cuniculi, a sister taxon...
2016: PloS One
https://www.readbyqxmd.com/read/27513403/the-high-prevalence-of-encephalitozoon-intestinalis-in-patients-receiving-chemotherapy-and-children-with-growth-retardation-and-the-validity-of-real-time-pcr-in-its-diagnosis
#17
Ülfet Çetinkaya, Süleyman Yazar, Salih Kuk, Eda Sivcan, Leylagül Kaynar, Duran Arslan, İzzet Şahin
BACKGROUND/AIM: The aim of this study was to investigate the presence of Encephalitozoon intestinalis in different patient groups consisting of immunocompromised and immunocompetent individuals. MATERIALS AND METHODS: The stool samples of 100 patients consisting of 25 patients receiving chemotherapy and with acute gastrointestinal complaints, 25 with bone marrow transplant and acute gastrointestinal complaints, 25 with urticaria, and 25 with growth retardation were included in the study...
June 23, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/27385082/triple-infection-with-agamid-adenovirus-1-encephaliton-cuniculi-like-microsporidium-and-enteric-coccidia-in-a-bearded-dragon-pogona-vitticeps
#18
Lionel Schilliger, Véronique Mentré, Rachel E Marschang, Alexandra Nicolier, Barbara Richter
A 2-month-old juvenile central bearded dragon was presented for anorexia and cachexia. Another specimen from the same cage had died suddenly 2 weeks prior. Fecal analysis revealed a high quantity of Isospora amphiboluri and a few pinworm eggs. Other examinations were not performed and the animal died a few days later despite supportive care. A third individual from the same cage presented with anorexia and a distended cœlom and was euthanized. In this third dragon, histological examination revealed intestinal coccidiosis, basophilic intranuclear inclusions compatible with adenovirus infection, acute hepatic necrosis with intrahepatocytic and intraenteritic organisms typical of microsporidia and renal gout...
October 12, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/27320966/serological-survey-of-encephalitozoon-cuniculi-infection-in-cats-in-japan
#19
Ryusuke Tsukada, Yuki Osaka, Tomomi Takano, Mizuki Sasaki, Mitsuhiro Inose, Hiromi Ikadai
Antibodies to Encephalitozoon cuniculi (E. cuniculi) were examined by enzyme-linked immunosorbent assay using E. cuniculi PTP2 recombinant protein from serum samples that had been collected from a total of 295 cats in Japan. Of these samples, 6.1% (18/295) had antibodies against E. cuniculi, which included 6.3% (6/96) of the male cats and 6.0% (12/199) of the female cats. The incidence was slightly higher in feral cats (8.3%, 11/132) compared to domesticated cats (4.3%, 7/163). This suggests the possibility that the cats of our country have become a reservoir of E...
November 1, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27266280/evaluation-of-pulmonary-microsporidiosis-in-iatrogenically-immunosuppressed-patients
#20
Soykan Özkoç, Songül Bayram Delibaş, Çiler Akısü
INTRODUCTION: Microsporidia spp. are ubiquitous and infect a wide variety of intervertebrates and vertebrates, including humans. Pulmonary microsporidiosis, characterized by nonspecific symptoms like fever, cough and dyspnea, is often overlooked in the differential diagnosis of pulmonary infections in immunsupressed patients. In this study, we aimed to determine the prevalence of pulmonary microsporidiosis in iatrogenically immunosuppressed patients and to evaluate the patient characteristics...
March 2016: Tüberküloz Ve Toraks
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