keyword
https://read.qxmd.com/read/38535562/ovine-herpesvirus-2-glycoprotein-b-complementation-restores-infectivity-to-a-bovine-herpesvirus-4-gb-null-mutant
#1
JOURNAL ARTICLE
Daniela D Moré, Katherine N Baker, Smriti Shringi, Reginaldo G Bastos, Donal O'Toole, Gaetano Donofrio, Cristina W Cunha
Ovine herpesvirus 2 (OvHV-2) and bovine herpesvirus 4 (BoHV-4) are gamma herpesviruses that belong to the genera Macavirus and Rhadinovirus , respectively. As with all herpesviruses, both OvHV-2 and BoHV-4 express glycoprotein B (gB), which plays an essential role in the infection of host cells. In that context, it has been demonstrated that a BoHV-4 gB-null mutant is unable to infect host cells. In this study, we used homologous recombination to insert OvHV-2 ORF 8, encoding gB, into the BoHV-4 gB-null mutant genome, creating a chimeric BoHV-4 virus carrying and expressing OvHV-2 gB (BoHV-4∆gB/OvHV-2-gB) that was infectious and able to replicate in vitro...
March 1, 2024: Pathogens
https://read.qxmd.com/read/38535341/development-of-a-technique-using-artificial-membrane-for-in-vitro-rearing-of-body-lice-pediculus-humanus-humanus
#2
JOURNAL ARTICLE
Alissa Hammoud, Meriem Louni, Linda Abou-Chacra, Gabriel Haddad, Noelle Mazzotti, Florence Fenollar, Oleg Mediannikov
Human lice are the only hematophagous ectoparasites specific to human hosts. They transmit epidemic typhus, trench fever and relapsing fever, diseases which have already caused millions of deaths worldwide. In order to further investigate lice vectorial capacities, laboratory-controlled live lice colonies are essential. Previously developed lice-rearing methods significantly advanced research on louse-borne diseases and louse biology. In this study, we aimed to develop a rearing technique for the Orlando (Or) strain of body lice on an artificial membrane...
February 21, 2024: Insects
https://read.qxmd.com/read/38535259/bone-marrow-derived-mesenchymal-stem-cell-laden-nanocomposite-scaffolds-enhance-bone-regeneration-in-rabbit-critical-size-segmental-bone-defect-model
#3
JOURNAL ARTICLE
Elangovan Kalaiselvan, Swapan Kumar Maiti, Shivaraju Shivaramu, Shajahan Amitha Banu, Khan Sharun, Divya Mohan, Sangeetha Palakkara, Sadhan Bag, Monalisa Sahoo, Suresh Ramalingam, Jürgen Hescheler
Bone regeneration poses a significant challenge in the field of tissue engineering, prompting ongoing research to explore innovative strategies for effective bone healing. The integration of stem cells and nanomaterial scaffolds has emerged as a promising approach, offering the potential to enhance regenerative outcomes. This study focuses on the application of a stem cell-laden nanomaterial scaffold designed for bone regeneration in rabbits. The in vivo study was conducted on thirty-six healthy skeletally mature New Zealand white rabbits that were randomly allocated into six groups...
March 10, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38534691/microbiological-quality-and-safety-of-fresh-rabbit-meat-with-special-reference-to-methicillin-resistant-s-aureus-mrsa-and-esbl-producing-e-coli
#4
JOURNAL ARTICLE
Jessica da Silva Guedes, David Velilla-Rodriguez, Elena González-Fandos
The purpose of this investigation was to evaluate the microbial quality and safety of rabbit meat. A total of 49 rabbit meat samples were taken at the retail level. The mesophiles, staphylococci, Enterobacterales , and Pseudomonas spp. counts were 4.94 ± 1.08, 2.59 ± 0.70, 2.82 ± 0.67, and 3.23 ± 0.76 log CFU/g, respectively. Campylobacter spp. were not detected in any sample. Listeria monocytogenes was isolated from one sample (2.04%) at levels below 1.00 log CFU/g. Multi-resistant S aureus was found in seven samples (14...
March 13, 2024: Antibiotics
https://read.qxmd.com/read/38534489/comparative-analysis-of-bone-regeneration-according-to-particle-type-and-barrier-membrane-for-octacalcium-phosphate-grafted-into-rabbit-calvarial-defects
#5
JOURNAL ARTICLE
Se-Wook Pyo, Jeong-Won Paik, Da-Na Lee, Young-Wook Seo, Jin-Young Park, Sunjai Kim, Seong-Ho Choi
This animal study was aimed to evaluate the efficacy of new bone formation and volume maintenance according to the particle type and the collagen membrane function for grafted octacalcium phosphate (OCP) in rabbit calvarial defects. The synthetic bone substitutes were prepared in powder form with 90% OCP and granular form with 76% OCP, respectively. The calvarial defects were divided into four groups according to the particle type and the membrane application. All specimens were acquired 2 weeks (n = 5) and 8 weeks (n = 5) after surgery...
February 24, 2024: Bioengineering
https://read.qxmd.com/read/38534392/eye-drop-with-fas-blocking-peptide-attenuates-age-related-macular-degeneration
#6
JOURNAL ARTICLE
Yujong Yi, Seon-Hong Pyun, Chae-Yeon Kim, Gyeongju Yun, Eunhwa Kang, Seoyoun Heo, Irfan Ullah, Sang-Kyung Lee
Age-related macular degeneration (AMD), characterized by macular retinal degeneration, poses a significant health concern due to the lack of effective treatments for prevalent dry AMD. The progression of AMD is closely linked to reactive oxygen species and Fas signaling, emphasizing the need for targeted interventions. In this study, we utilized a NaIO3 -induced retinal degeneration mouse model to assess the efficacy of Fas-blocking peptide (FBP). Intravitreal administration of FBP successfully suppressed Fas-mediated inflammation and apoptosis, effectively arresting AMD progression in mice...
March 20, 2024: Cells
https://read.qxmd.com/read/38534380/fluvastatin-converts-human-macrophages-into-foam-cells-with-increased-inflammatory-response-to-inactivated-mycobacterium-tuberculosis-h37ra
#7
JOURNAL ARTICLE
María Teresa Montero-Vega, Joaquín Matilla, Eulalia Bazán, Diana Reimers, Ana De Andrés-Martín, Rafael Gonzalo-Gobernado, Carlos Correa, Francisco Urbano, Diego Gómez-Coronado
Cholesterol biosynthesis inhibitors (statins) protect hypercholesterolemic patients against developing active tuberculosis, suggesting that these drugs could help the host to control the pathogen at the initial stages of the disease. This work studies the effect of fluvastatin on the early response of healthy peripheral blood mononuclear cells (PBMCs) to inactivated Mycobacterium tuberculosis (Mtb) H37Ra . We found that in fluvastatin-treated PBMCs, most monocytes/macrophages became foamy cells that overproduced NLRP3 inflammasome components in the absence of immune stimulation, evidencing important cholesterol metabolism/immunity connections...
March 18, 2024: Cells
https://read.qxmd.com/read/38534300/in-vivo-evaluation-of-regenerative-osteogenic-potential-using-a-human-demineralized-dentin-matrix-for-dental-application
#8
JOURNAL ARTICLE
Nessma Sultan, Soher Nagi Jayash
BACKGROUND: The use of a demineralized dentin matrix (DDM) has garnered substantial importance in dentistry. This study was carried out to evaluate the osteoinductive performance of DDM in comparison to nano-hydroxyapatite (n-HA) on calvarial critical-sized bone defect. METHODS: Two critical-sized defects (CSDs) were bilaterally trephined in the calvarium of sixteen healthy white rabbits. The rabbits were categorized into four groups: in group 1, the defect was left empty; in group 2, defects were filled with sodium alginate (SA) hydrogel as a sole material; in group 3, defects were treated with nano-hydroxyapatite hydrogel (NHH); in group 4, defects were treated using demineralized dentin matrix hydrogel (DDMH)...
March 18, 2024: Dentistry Journal
https://read.qxmd.com/read/38534273/mandibular-endochondral-growth-is-specifically-augmented-by-nutritional-supplementation-with-myo-inositol-even-in-rabbits
#9
JOURNAL ARTICLE
Miho Shimoyama, Hiroyuki Kanzaki, Syunnosuke Tohyama, Tomomi Ida, Misao Ishikawa, Yuta Katsumata, Chihiro Arai, Satoshi Wada, Shugo Manase, Hiroshi Tomonari
Mandibular retrognathism occurs by insufficient mandibular growth and causes several issues, such as respiratory difficulty and diminished masticatory function. At present, functional orthodontic appliances are used for stimulating mandibular growth in pediatric cases. However, the effectiveness of functional appliances is not always stable in daily practices. A more effective, reliable, and safer therapeutic method for mandibular growth promotion would be helpful for growing mandibular retrognathism patients...
February 26, 2024: Dentistry Journal
https://read.qxmd.com/read/38533194/sars-cov-and-sars-cov-2-cross-reactive-antibodies-in-domestic-animals-and-wildlife-in-nigeria-suggest-circulation-of-sarbecoviruses
#10
JOURNAL ARTICLE
Ebere R Agusi, Jacob Schön, Valerie Allendorf, Emmanuel A Eze, Olayinka Asala, Ismaila Shittu, Anne Balkema-Buschmann, Kerstin Wernike, Ishaya Tekki, Mark Ofua, Omowunmi Adefegha, Oluwatoyin Olubade, Oluyemi Ogunmolawa, Klaas Dietze, Anja Globig, Donata Hoffmann, Clement A Meseko
Anthropogenic exposure of domestic animals, as well as wildlife, can result in zoonotic transmission events with known and unknown pathogens including sarbecoviruses. During the COVID-19 pandemic, SARS-CoV-2 infections in animals, most likely resulting from spill-over from humans, have been documented worldwide. However, only limited information is available for Africa. The anthropozoonotic transmission from humans to animals, followed by further inter- and intraspecies propagation may contribute to viral evolution, and thereby subsequently alter the epidemiological patterns of transmission...
June 2024: One Health
https://read.qxmd.com/read/38532494/epidemiological-characterization-and-risk-assessment-of-rabbit-haemorrhagic-disease-virus-2-rhdv2-b-gi-2-in-the-world
#11
JOURNAL ARTICLE
Zhuo Sun, Qi An, Yuepeng Li, Xiang Gao, Hongbin Wang
A novel variant of rabbit haemorrhagic disease virus, designated RHDV2/b/GI.2, was first discovered in France in 2010. Subsequently, RHDV2 rapidly spread to Africa, North America, Australia, and Asia. RHDV2 outbreaks have resulted in significant economic losses in the global rabbit industry and disrupted the balance of natural ecosystems. Our study investigated the seasonal characteristics of RHDV2 outbreaks using seasonal indices. RHDV2 is prone to causing significant outbreaks within domestic and wild rabbit populations during the spring season and is more likely to induce outbreaks within wild rabbit populations during late autumn in the Southern Hemisphere...
March 26, 2024: Veterinary Research
https://read.qxmd.com/read/38532491/non-specific-effects-of-inactivated-mycobacterium-bovis-oral-and-parenteral-treatment-in-a-rabbit-scabies-model
#12
JOURNAL ARTICLE
Rosa Casais, Natalia Iglesias, Iker A Sevilla, Joseba M Garrido, Ana Balseiro, Mercedes Dominguez, Ramon A Juste
Tuberculosis BCG vaccination induced non-specific protective effects in humans led to postulate the concept of trained immunity (TRAIM) as an innate type of immune mechanism that triggered by a pathogen, protects against others. Killed vaccines have been considered not to be effective. However, field efficacy of a commercial vaccine against paratuberculosis, as well as of a recently developed M. bovis heat-inactivated vaccine (HIMB) prompted to test whether it could also induce TRAIM. To this, we used a sarcoptic mange rabbit model...
March 26, 2024: Veterinary Research
https://read.qxmd.com/read/38532474/an-investigation-into-how-accurately-uk-rabbit-owners-identify-pain-in-their-pet-rabbits
#13
JOURNAL ARTICLE
Charlotte Forder, Livia Benato, Nicola J Rooney
BACKGROUND: Rabbits are popular family pets. They are prey species and so have evolved to hide signs of illness and pain. Recent research has developed robust pain scales for use in a clinical setting, but to date none has examined rabbit owners' ability to recognise pain in their animals. This study investigated how owners identify pain in their pet rabbits and their ability to correctly identify different levels of pain, in order to determine any need for owner education in this area...
March 27, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38532399/octn2-and-atb-0-targeted-nanoemulsions-for-improving-ocular-drug-delivery
#14
JOURNAL ARTICLE
Bo Tang, Qiuxiang Wang, Guowei Zhang, Aiwen Zhang, Lu Zhu, Rongrong Zhao, Hongwei Gu, Jie Meng, Junfang Zhang, Guihua Fang
Traditional eye drops are administered via topical instillation. However, frequent dosing is needed due to their relatively rapid precorneal removal and low ocular bioavailability. To address these issues, stearoyl L-carnitine-modified nanoemulsions (SC-NEs) were fabricated. The physicochemical properties of SC-NEs in terms of size, morphology, zeta potential, encapsulation efficiency, and in vitro drug release behavior were characterized. The cellular uptake and mechanisms of SC-NEs were comprehensively studied in human corneal epithelial cells and the stearoyl L-carnitine ratio in SC-NEs was optimized...
March 26, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38532200/investigation-of-two-new-grafting-techniques-for-dorsal-augmentation-rhinoplasty-an-experimental-study-with-new-zealand-white-rabbits
#15
JOURNAL ARTICLE
Mehmet Ozdemır, Mehmet Fatih Akkoç, Selcuk Tunık
INTRODUCTION: Cartilage is an important source in supporting the structure of the nose for dorsal augmentation rhinoplasty. However, it is known that its viability is not always on the ideal level. Various wrapping materials are used to increase the strength of cartilage. Donor site morbidity, which develops following the harvesting of both cartilage and fascia as one such cover material, has attracted interest in recent years. OBJECTIVE: In this study, we aimed to investigate the potential of dermis and tendon autografts as alternatives to fascia and cartilage...
March 26, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38531881/silk-fibroin-hydrogel-adhesive-enables-sealed-tight-reconstruction-of-meniscus-tears
#16
JOURNAL ARTICLE
Xihao Pan, Rui Li, Wenyue Li, Wei Sun, Yiyang Yan, Xiaochen Xiang, Jinghua Fang, Youguo Liao, Chang Xie, Xiaozhao Wang, Youzhi Cai, Xudong Yao, Hongwei Ouyang
Despite orientationally variant tears of the meniscus, suture repair is the current clinical gold treatment. However, inaccessible tears in company with re-tears susceptibility remain unresolved. To extend meniscal repair tools from the perspective of adhesion and regeneration, we design a dual functional biologic-released bioadhesive (S-PIL10) comprised of methacrylated silk fibroin crosslinked with phenylboronic acid-ionic liquid loading with growth factor TGF-β1, which integrates chemo-mechanical restoration with inner meniscal regeneration...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531116/grating-lobe-mitigation-on-large-pitch-arrays-using-null-subtraction-imaging
#17
JOURNAL ARTICLE
Mick Gardner, Rita J Miller, Michael L Oelze
Null Subtraction Imaging (NSI) is a novel beamforming technique that can produce B-mode images resulting in high spatial resolution and low computational cost compared to other beamforming techniques. Previous work has demonstrated that in addition to a beam pattern with a narrow main lobe and low side lobes, NSI can also reduce or mitigate grating lobes, which can appear when the array pitch is larger than one half the wavelength of the transmitted pulse. These grating lobes can result in imaging artifacts that produce clutter and lower contrast...
March 24, 2024: Ultrasonics
https://read.qxmd.com/read/38530888/normalizing-granuloma-vasculature-and-matrix-improves-drug-delivery-and-reduces-bacterial-burden-in-tuberculosis-infected-rabbits
#18
JOURNAL ARTICLE
Meenal Datta, Laura E Via, Véronique Dartois, Danielle M Weiner, Matthew Zimmerman, Firat Kaya, April M Walker, Joel D Fleegle, Isaac D Raplee, Colton McNinch, Maksym Zarodniuk, Walid S Kamoun, Changli Yue, Ashwin S Kumar, Sonu Subudhi, Lei Xu, Clifton E Barry, Rakesh K Jain
Host-directed therapies (HDTs) represent an emerging approach for bacterial clearance during tuberculosis (TB) infection. While most HDTs are designed and implemented for immuno-modulation, other host targets-such as nonimmune stromal components found in pulmonary granulomas-may prove equally viable. Building on our previous work characterizing and normalizing the aberrant granuloma-associated vasculature, here we demonstrate that FDA-approved therapies (bevacizumab and losartan, respectively) can be repurposed as HDTs to normalize blood vessels and extracellular matrix (ECM), improve drug delivery, and reduce bacterial loads in TB granulomas...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38530631/extra-corporeal-non-liver-transplant-therapies-for-acute-liver-failure-focus-on-plasma-exchange-and-continuous-renal-replacement-therapy
#19
REVIEW
Uday Zachariah, Balakrishnan Vijayalekshmi, Smita M Matthai, Ashish Goel, Chundamannil E Eapen
The acute inflammatory milieu in patients with acute liver failure (ALF) results in 'toxic' blood in these patients. In vitro experiments have shown that the plasma obtained from ALF patients is toxic to rabbit hepatocytes and inhibits regeneration of rat hepatocytes. Treatments such as plasma exchange and continuous renal replacement therapy to cleanse the blood have improved survival in ALF patients. In the liver microcirculation, the exchange of fluid across fenestrae in liver sinusoidal endothelial cells (LSECs) is vital for proper functioning of hepatocytes...
March 26, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://read.qxmd.com/read/38530161/subperiosteal-delivery-of-transforming-growth-factor-beta-1%C3%A2-and-human-growth-hormone-from-mineralized-pcl-films
#20
JOURNAL ARTICLE
Matthew B Parlato, Jae Sung Lee, David G Belair, Gianluca Fontana, Ellen Leiferman, Rewais Hanna, Connie Chamberlain, Erik A Ranheim, William L Murphy, Matthew A Halanski
The ability to locally deliver bioactive molecules to distinct regions of the skeleton may provide a novel means by which to improve fracture healing, treat neoplasms or infections, or modulate growth. In this study, we constructed single-sided mineral-coated poly-ε-caprolactone membranes capable of binding and releasing transforming growth factor beta 1 (TGF-β1) and human growth hormone (hGH). After demonstrating biological activity in vitro and characterization of their release, these thin bioabsorbable membranes were surgically implanted using an immature rabbit model...
March 26, 2024: Journal of Biomedical Materials Research. Part A
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