keyword
https://read.qxmd.com/read/37223676/a-triple-drug-combination-induces-apoptosis-in-cervical-cancer-derived-cell-lines
#1
JOURNAL ARTICLE
Izamary Delgado-Waldo, Carlos Contreras-Romero, Sandra Salazar-Aguilar, João Pessoa, Irma Mitre-Aguilar, Verónica García-Castillo, Carlos Pérez-Plasencia, Nadia Judith Jacobo-Herrera
INTRODUCTION: Cervical cancer is a worldwide health problem due to the number of deaths caused by this neoplasm. In particular, in 2020, 30,000 deaths of this type of tumor were reported in Latin America. Treatments used to manage patients diagnosed in the early stages have excellent results as measured by different clinical outcomes. Existing first-line treatments are not enough to avoid cancer recurrence, progression, or metastasis in locally advanced and advanced stages. Therefore, there is a need to continue with the proposal of new therapies...
2023: Frontiers in Oncology
https://read.qxmd.com/read/36221097/early-effects-of-lps-induced-neuroinflammation-on-the-rat-hippocampal-glycolytic-pathway
#2
JOURNAL ARTICLE
Adriana Fernanda K Vizuete, Fernanda Fróes, Marina Seady, Caroline Zanotto, Larissa Daniele Bobermin, Ana Cristina Roginski, Moacir Wajner, André Quincozes-Santos, Carlos Alberto Gonçalves
Neuroinflammation is a common feature during the development of neurological disorders and neurodegenerative diseases, where glial cells, such as microglia and astrocytes, play key roles in the activation and maintenance of inflammatory responses in the central nervous system. Neuroinflammation is now known to involve a neurometabolic shift, in addition to an increase in energy consumption. We used two approaches (in vivo and ex vivo) to evaluate the effects of lipopolysaccharide (LPS)-induced neuroinflammation on neurometabolic reprogramming, and on the modulation of the glycolytic pathway during the neuroinflammatory response...
October 11, 2022: Journal of Neuroinflammation
https://read.qxmd.com/read/34123772/combination-of-metformin-sodium-oxamate-and-doxorubicin-induces-apoptosis-and-autophagy-in-colorectal-cancer-cells-via-downregulation-hif-1%C3%AE
#3
JOURNAL ARTICLE
Jossimar Coronel-Hernández, Rebeca Salgado-García, David Cantú-De León, Nadia Jacobo-Herrera, Oliver Millan-Catalan, Izamary Delgado-Waldo, Alma D Campos-Parra, Miguel Rodríguez-Morales, Norma L Delgado-Buenrostro, Carlos Pérez-Plasencia
Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide in both sexes. Current therapies include surgery, chemotherapy, and targeted therapy; however, prolonged exposure to chemical agents induces toxicity in patients and drug resistance. So, we implemented a therapeutic strategy based on the combination of doxorubicin, metformin, and sodium oxamate called triple therapy (Tt). We found that Tt significantly reduced proliferation by inhibiting the mTOR/AKT pathway and promoted apoptosis and autophagy in CRC derived cells compared with doxorubicin...
2021: Frontiers in Oncology
https://read.qxmd.com/read/33572255/negative-regulation-of-ulk1-by-microrna-106a-in-autophagy-induced-by-a-triple-drug-combination-in-colorectal-cancer-cells-in-vitro
#4
JOURNAL ARTICLE
Rebeca Salgado-García, Jossimar Coronel-Hernández, Izamary Delgado-Waldo, David Cantú de León, Verónica García-Castillo, Eduardo López-Urrutia, Ma Concepción Gutiérrez-Ruiz, Carlos Pérez-Plasencia, Nadia Jacobo-Herrera
Colorectal cancer (CRC) is among the top three most deadly cancers worldwide. The survival rate for this disease has not been reduced despite the treatments, the reason why the search for therapeutic alternatives continues to be a priority issue in oncology. In this research work, we tested our successful pharmacological combination of three drugs, metformin, doxorubicin, and sodium oxamate (triple therapy, or TT), as an autophagy inducer. Firstly, we employed western blot (WB) assays, where we observed that after 8 h of stimulation with TT, the proteins Unc-51 like autophagy activating kinase 1(ULK1), becline-1, autophagy related 1 protein (Atg4), and LC3 increased in the CRC cell lines HCT116 and SW480 in contrast to monotherapy with doxorubicin...
February 9, 2021: Genes
https://read.qxmd.com/read/33498369/beyond-the-warburg-effect-oxidative-and-glycolytic-phenotypes-coexist-within-the-metabolic-heterogeneity-of-glioblastoma
#5
JOURNAL ARTICLE
Tomás Duraj, Noemí García-Romero, Josefa Carrión-Navarro, Rodrigo Madurga, Ana Ortiz de Mendivil, Ricardo Prat-Acin, Lina Garcia-Cañamaque, Angel Ayuso-Sacido
Glioblastoma (GBM) is the most aggressive primary brain tumor, with a median survival at diagnosis of 16-20 months. Metabolism represents a new attractive therapeutic target; however, due to high intratumoral heterogeneity, the application of metabolic drugs in GBM is challenging. We characterized the basal bioenergetic metabolism and antiproliferative potential of metformin (MF), dichloroacetate (DCA), sodium oxamate (SOD) and diazo-5-oxo-L-norleucine (DON) in three distinct glioma stem cells (GSCs) (GBM18, GBM27, GBM38), as well as U87MG...
January 20, 2021: Cells
https://read.qxmd.com/read/29866066/expression-of-glycolytic-enzymes-in-ovarian-cancers-and-evaluation-of-the-glycolytic-pathway-as-a-strategy-for-ovarian-cancer-treatment
#6
JOURNAL ARTICLE
Chrysi Xintaropoulou, Carol Ward, Alan Wise, Suzanna Queckborner, Arran Turnbull, Caroline O Michie, Alistair R W Williams, Tzyvia Rye, Charlie Gourley, Simon P Langdon
BACKGROUND: Novel therapeutic approaches are required to treat ovarian cancer and dependency on glycolysis may provide new targets for treatment. This study sought to investigate the variation of expression of molecular components (GLUT1, HKII, PKM2, LDHA) of the glycolytic pathway in ovarian cancers and the effectiveness of targeting this pathway in ovarian cancer cell lines with inhibitors. METHODS: Expression of GLUT1, HKII, PKM2, LDHA were analysed by quantitative immunofluorescence in a tissue microarray (TMA) analysis of 380 ovarian cancers and associations with clinicopathological features were sought...
June 5, 2018: BMC Cancer
https://read.qxmd.com/read/28728159/oxamate-enhances-the-anti-inflammatory-and-insulin-sensitizing-effects-of-metformin-in-diabetic-mice
#7
JOURNAL ARTICLE
Mu-Chao Wu, Wei-Ran Ye, Yi-Jia Zheng, Shan-Shan Zhang
Metformin (MET) is the first-line drug for treating type 2 diabetes mellitus (T2DM). However, MET increases blood lactate levels in patients with T2DM. Lactate possesses proinflammatory properties and causes insulin resistance (IR). Oxamate (OXA), a lactate dehydrogenase inhibitor, can decrease tissue lactate production and blood lactate levels. This study was conducted to examine the effects of the combination of OXA and MET on inflammation, and IR in diabetic db/db mice. Supplementation of OXA to MET led to lowered tissue lactate production and serum lactate levels compared to MET alone, accompanied with further decreased tissue and blood levels of pro-inflammatory cytokines, along with better insulin sensitivity, beta-cell mass, and glycemic control in diabetic db/db mice...
2017: Pharmacology
https://read.qxmd.com/read/28243322/targeting-metabolic-remodeling-in-triple-negative-breast-cancer-in-a-murine-model
#8
JOURNAL ARTICLE
Verónica García-Castillo, Eduardo López-Urrutia, Octavio Villanueva-Sánchez, Miguel Á Ávila-Rodríguez, Alejandro Zentella-Dehesa, Carlo Cortés-González, César López-Camarillo, Nadia J Jacobo-Herrera, Carlos Pérez-Plasencia
Background: Chemotherapy is the backbone of systemic treatment for triple negative breast cancer (TNBC), which is one of the most relevant breast cancers molecular types due to the ability of tumor cells to develop drug resistance, highlighting the urgent need to design newer and safer drug combinations for treatment. In this context, to overcome tumor cell drug resistance, we employed a novel combinatorial treatment including Doxorubicin, Metformin, and Sodium Oxamate (DoxMetOx). Such pharmacological combination targets indispensable hallmarks of cancer-related to aerobic glycolysis and DNA synthesis...
2017: Journal of Cancer
https://read.qxmd.com/read/27698900/anti-inflammatory-and-antitumor-activity-of-a-triple-therapy-for-a-colitis-related-colorectal-cancer
#9
JOURNAL ARTICLE
Gabriela Figueroa-González, Verónica García-Castillo, Jossimar Coronel-Hernández, Eduardo López-Urrutia, Sonia León-Cabrera, Luis E Arias-Romero, L I Terrazas, Miriam Rodríguez-Sosa, Alma Delia Campos-Parra, Eduardo Zúñiga-Calzada, Cesar Lopez-Camarillo, Fermín Morales-González, Nadia J Jacobo-Herrera, Carlos Pérez-Plasencia
Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of cancer incidence. Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, is the most important risk factor for developing CRC, as it favours neoplastic transformation by enhancing epithelial cell turnover in the colonic mucosa. Treatments for CRC need to be improved; currently they are not specific and have several secondary effects in patients. The main objective of this work was to evaluate a new therapeutic strategy against a colitis-related colorectal cancer in vivo and in vitro by targeting mTOR-signaling and lactate dehydrogenase A...
2016: Journal of Cancer
https://read.qxmd.com/read/26259240/a-comparative-analysis-of-inhibitors-of-the-glycolysis-pathway-in-breast-and-ovarian-cancer-cell-line-models
#10
COMPARATIVE STUDY
Chrysi Xintaropoulou, Carol Ward, Alan Wise, Hugh Marston, Arran Turnbull, Simon P Langdon
Many cancer cells rely on aerobic glycolysis for energy production and targeting of this pathway is a potential strategy to inhibit cancer cell growth. In this study, inhibition of five glycolysis pathway molecules (GLUT1, HKII, PFKFB3, PDHK1 and LDH) using 9 inhibitors (Phloretin, Quercetin, STF31, WZB117, 3PO, 3-bromopyruvate, Dichloroacetate, Oxamic acid, NHI-1) was investigated in panels of breast and ovarian cancer cell line models. All compounds tested blocked glycolysis as indicated by increased extracellular glucose and decreased lactate production and also increased apoptosis...
September 22, 2015: Oncotarget
https://read.qxmd.com/read/24465604/synergistic-anti-cancer-effect-of-phenformin-and-oxamate
#11
JOURNAL ARTICLE
W Keith Miskimins, Hyun Joo Ahn, Ji Yeon Kim, Sun Ryu, Yuh-Seog Jung, Joon Young Choi
Phenformin (phenethylbiguanide; an anti-diabetic agent) plus oxamate [lactate dehydrogenase (LDH) inhibitor] was tested as a potential anti-cancer therapeutic combination. In in vitro studies, phenformin was more potent than metformin, another biguanide, recently recognized to have anti-cancer effects, in promoting cancer cell death in the range of 25 times to 15 million times in various cancer cell lines. The anti-cancer effect of phenformin was related to complex I inhibition in the mitochondria and subsequent overproduction of reactive oxygen species (ROS)...
2014: PloS One
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