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Thyroid nodules

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https://www.readbyqxmd.com/read/28108635/follicular-thyroid-carcinoma-presenting-with-pathological-fracture-of-the-humerus-at-initial-diagnosis
#1
Wanding Yang, WaiSum Cho, Sudip Das, Peter Conboy
Differentiated carcinomas of the thyroid gland usually have a good prognosis with prognosis often discussed in terms of 20 year survival. Nevertheless its 10-year-survival rate decreases when accompanied by distant metastasis. Follicular thyroid cancer (FTC) is the second most common thyroid cancer and usually presents with a solitary thyroid nodule with or without cervical lymphadenopathy. Distance metastasis at initial diagnosis is seldom observed with incidence range from 1 to 9%. In cases of bone metastasis, the incidence is only 2-3% and weight-bearing skeleton is preferentially affected...
January 19, 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28107199/the-prevalence-of-thyroid-nodules-in-northwest-china-and-its-correlation-with-metabolic-parameters-and-uric-acid
#2
Yao Liu, Ziwei Lin, Chunjun Sheng, Yikun Zhu, Yun Huang, Ni Zhong, Zhao Jia, Shen Qu
This study aimed to estimate the prevalence of thyroid nodules (TN) and investigate its correlation with metabolic parameters, especially uric acid (UA) in northwest Chinese population. We conducted a large cross-sectional survey with 67,781 residents (33,020 men, 34,761 women), aged from 18 to 86 years in Shanxi, China, from January 2012 to December 2014. A thyroid ultrasound examination was performed with number and size of nodules being recorded. Metabolic parameters including body mass index (BMI), blood pressure (BP), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), fasting glucose (FG), and uric acid (UA) were also examined...
January 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28104680/evaluation-of-thyroseq-v2-performance-in-thyroid-nodules-with-indeterminate-cytology
#3
Pablo Valderrabano, Laila Khazai, Marino E Leon, Zachary J Thompson, Zhenjun Ma, Christine H Chung, Julie E Hallanger-Johnson, Kristen J Otto, Kara D Rogers, Barbara Centeno, Bryan McIver
ThyroSeq v2 claims high positive (PPV) and negative (NPV) predictive values in a wide range of pre-test risks of malignancy in indeterminate thyroid nodules (ITNs) (categories B-III and B-IV of the Bethesda system). We evaluated ThyroSeq v2 performance in a cohort of patients with ITNs seen at our Academic Cancer Center from September 2014 to April 2016, in light of the new diagnostic criteria for non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Our study included 182 patients (76% female) with 190 ITNs consecutively tested with ThyroSeq v2...
January 19, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28101485/minimizing-the-health-effects-of-the-nuclear-accident-in-fukushima-on-thyroids
#4
REVIEW
Shigenobu Nagataki
RESULTS OF THE SCREENING OF THYROIDS: Because of the March 2011 nuclear accident in Fukushima, Japan, the Fukushima Prefecture initiated a thyroid ultrasound examination program. The first cycle of examinations on all children (more than 300,000) of the Fukushima Prefecture identified 116 patients as having malignant or suspected malignant thyroid nodules, and in the second cycle 59 new cases were identified. According to the available data, the thyroid cancers found by the screening are unlikely to be due to radiation, but the possibility cannot be excluded...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28101352/shear-wave-elastography-and-contrast-enhanced-ultrasonography-in-the-diagnosis-of-thyroid-malignant-nodules
#5
Mei Chen, Ke-Qin Zhang, You-Feng Xu, Sheng-Min Zhang, Yong Cao, Wei-Qun Sun
The aim of the present study was to evaluate the value of shear wave elastography (SWE) and contrast-enhanced ultrasonography (CEUS) in the diagnosis of thyroid malignant nodules. A total of 253 patients with 319 thyroid nodules were subjected to two-dimensional ultrasound (2DUS) and CEUS examinations prior to thyroidectomy between March, 2014 and December, 2015. Young's modulus value for each nodule on 2DUS and CEUS images were recorded. The sensitivity, specificity and accuracy of 2DUS, SWE and CEUS in the diagnosis of thyroid malignant nodules were assessed...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28096731/core-needle-biopsy-of-the-thyroid-2016-consensus-statement-and-recommendations-from-korean-society-of-thyroid-radiology
#6
REVIEW
Dong Gyu Na, Jung Hwan Baek, So Lyung Jung, Ji-Hoon Kim, Jin Yong Sung, Kyu Sun Kim, Jeong Hyun Lee, Jung Hee Shin, Yoon Jung Choi, Eun Ju Ha, Hyun Kyung Lim, Soo Jin Kim, Soo Yeon Hahn, Kwang Hwi Lee, Young Jun Choi, Inyoung Youn, Young Joong Kim, Hye Shin Ahn, Ji Hwa Ryu, Seon Mi Baek, Jung Suk Sim, Chan Kwon Jung, Joon Hyung Lee
Core needle biopsy (CNB) has been suggested as a complementary diagnostic method to fine-needle aspiration in patients with thyroid nodules. Many recent CNB studies have suggested a more advanced role for CNB, but there are still no guidelines on its use. Therefore, the Task Force Committee of the Korean Society of Thyroid Radiology has developed the present consensus statement and recommendations for the role of CNB in the diagnosis of thyroid nodules. These recommendations are based on evidence from the current literature and expert consensus...
January 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28095042/gauging-the-extent-of-thyroidectomy-for-indeterminate-thyroid-nodules-an-oncologic-perspective
#7
David F Schneider, Linda M Cherney Stafford, Nicole Brys, Caprice C Greenberg, Courtney J Balentine, Dawn M Elfenbein, Susan C Pitt
INTRODUCTION: Increasing emphasis is being placed on appropriateness of care and avoidance of over- and under-treatment. Indeterminate thyroid nodules (ITN), present a particular risk for this problem because cancer found via diagnostic lobectomy (DL) often requires a completion thyroidectomy (CT). However, initial total thyroidectomy (TT) for benign ITN results in lifelong thyroid hormone replacement. We sought to measure the accuracy and factors associated with the extent of initial thyroidectomy for ITN...
January 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28092147/should-serum-calcitonin-be-routinely-measured-in-patients-presenting-with-thyroid-nodule
#8
William P Tormey, Brendan Byrne, Arnold D Hill, Mark Sherlock, Christopher J Thompson
BACKGROUND: The European Thyroid Association recommends serum calcitonin measurement in thyroid nodule cases. In contrast, the American Thyroid Association is ambivalent. In this institution, thyroid nodules cases are subject to a multidisciplinary evaluation of the clinical history and examination, ultrasound and scintigraphy, CT scan and sometimes MRI scan, biochemistry and histopathology of biopsies. We report on the current use of plasma calcitonin measurements in the context of changing practice which has not included screening of all thyroid nodules...
January 13, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28087101/current-management-of-low-risk-differentiated-thyroid-cancer-and-papillary-microcarcinoma
#9
V D Tarasova, R M Tuttle
Each year, the proportion of thyroid cancer patients presenting with low risk disease is increasing. Moreover, the definition of low risk thyroid cancer is expanding and several histological subtypes beyond papillary microcarcinomas are now classified as low risk disease. This shift in the landscape of thyroid cancer presentation is forcing clinicians to critically re-evaluate whether or not traditional management paradigms that were effective in treating intermediate and high risk disease are applicable to these low risk patients...
January 10, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28081315/the-association-of-papillary-thyroid-cancer-with-microcalcification-in-thyroidnodules-with-indeterminate-cytology-based-on-fine-needle-aspiration-biopsy
#10
İbrahim Ali Özemir, Barış Bayraktar, Ender Anılır, Kıvılcım Orhun, Tunç Eren, Jülide Sağıroğlu, Ayşe Bahar Ceyran, Rafet Yiğitbaşı, Orhan Alimoğlu
BACKGROUND/AIM: Microcalcifications are generally accepted as highly specific for thyroid malignancy, especially for papillary thyroid carcinoma (PTC). The aim of this study was to determine the significance of microcalcification within nodules that were classified as being of “indeterminate cytology” (IC) according to fine-needle aspiration biopsy. MATERIALS AND METHODS: Patients who underwent thyroidectomy between January 2010 and 2013 were included in the study...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28078873/fine-needle-aspiration-cytology-of-650-thyroid-nodules-operated-for-multinodular-goiter-a-cyto-histological-correlation-based-on-the-new-italian-cytological-classification-siapec-2014
#11
F Tartaglia, A Giuliani, L Tromba, S Carbotta, M Karpathiotakis, G Tortorelli, F Pelle, R Merola, C Donello, G Carbotta, L De Anna, G Conzo, S Sorrenti, S Ulisse
The new Italian cytological classification (SIAPEC 2014) of thyroid nodules, in line with those of Bethesda and BTA-RCPath, replaces the previous TIR3 class with two new classes (TIR3A and TIR3B), which correspond to different risks of malignancy and clinical actions required. The present study was conducted to evaluate the diagnostic accuracy of the new SIAPEC classification as opposed to its previous version (SIAPEC 2007). Preoperative cytology was compared with the final histology obtained from 650 consecutive patients who underwent total thyroidectomy for multinodular goiter...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28077891/evaluation-the-relationship-between-thyroid-nodule-size-with-malignancy-and-accuracy-of-fine-needle-aspiration-biopsy-fnab
#12
Gholamali Godazandeh, Zahra Kashi, Sadegh Zargarnataj, Mehran Fazli, Robab Ebadi, Ensiyeh Hajializadeh Kerdabadi
INTRODUCTION: Some studies have shown largest thyroid nodule size, especially ≥4cm that can predict malignancy and reduce fine needle aspiration biopsy (FNAB) accuracy. Therefore, this study is designed to evaluate relationship between thyroid nodule sizes with malignancy and its effect on FNBA accuracy. MATERIALS AND METHODS: a retrospective analytical study design aims to investigate all patients with thyroid nodules who referred to surgery department of Imam-Khomeini Hospital of Mazandaran University of Medical Sciences in Sari from 20 March 2008 to 22 March 2014...
October 2016: Acta Informatica Medica: AIM
https://www.readbyqxmd.com/read/28077785/the-diagnostic-performance-of-shear-wave-speed-sws-imaging-for-thyroid-nodules-with-elasticity-modulus-and-sws-measurement
#13
Dan Wang, Ya-Ping He, Yi-Feng Zhang, Bo-Ji Liu, Chong-Ke Zhao, Hui-Jun Fu, Qing Wei, Hui-Xiong Xu
To evaluate the diagnostic performance of a new technique of shear wave speed (SWS) imaging for the diagnosis of thyroid nodule with elasticity modulus and SWS measurement. 322 thyroid nodules in 322 patients (216 benign nodules, 106 malignant nodules) were included in this study. All the nodules received conventional ultrasound (US) and SWS imaging (Aplio500, Toshiba Medical Systems, Japan) before fine-needle aspiration (FNA) and/or surgery. The values of E-max and E-mean with elastic modulus (61.27 ± 36...
January 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28073489/cost-comparison-of-initial-lobectomy-versus-fine-needle-aspiration-for-diagnostic-workup-of-thyroid-nodules-in-children
#14
Katherine J Baxter, Heather L Short, Mitali A Thakore, Jeremy G Fisher, David H Rothstein, Kurt F Heiss, Mehul V Raval
BACKGROUND: Though uncommon in children, pediatric thyroid nodules carry a higher risk of malignancy than adult nodules. While fine-needle aspiration (FNA) has been well established as the initial diagnostic test in adults, it has been more slowly adopted in children. The purpose of this study was to examine the comparative cost of FNA versus initial diagnostic lobectomy (DL) in the pediatric patient with an ultrasound-confirmed thyroid nodule. METHODS: A decision tree model was created using an adolescent with an asymptomatic thyroid nodule as the reference case...
December 30, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28071987/a-computer-aided-diagnosis-system-using-artificial-intelligence-for-the-diagnosis-and-characterization-of-thyroid-nodules-on-ultrasound-initial-clinical-assessment
#15
Young Jun Choi, Jung Hwan Baek, Hye Sun Park, Woo Hyun Shim, Tae Yong Kim, YoungKee Shong, Jeong Hyun Lee
Background We describe an initial clinical assessment of a new, commercially available, computer-aided diagnosis (CAD) system using artificial intelligence (AI) for thyroid ultrasound, and evaluate its performance in the diagnosis of malignant thyroid nodules and categorization of nodule characteristics. Methods This prospective study protocol was reviewed and approved by the institutional review board. Patients with thyroid nodules with decisive diagnosis, whether benign or malignant on the basis of cytopathologic or US results, were consecutively enrolled from November 2015 to February 2016...
January 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28071986/evaluation-of-a-two-year-routine-application-of-molecular-testing-of-thyroid-fine-needle-aspirations-fna-using-a-7-gene-panel-in-a-primary-referral-setting-in-germany
#16
Markus Eszlinger, Katharina Böhme, Maha Ullmann, Fabian Görke, Udo Siebolts, Anna Neumann, Christiane Franzius, Sabine Adam, Thomas Molwitz, Christian Landvogt, Bassam Amro, Anja Hach, Berit Feldmann, Dieter Graf, Antje Wefer, Rainer Niemann, Catharina Bullmann, Günther Klaushenke, Reinhard Santen, Gregor Tönshoff, Velimir Ivancevic, Andreas Kögler, Eberhard Bell, Bernd Lorenz, Gerald Kluge, Christoph Hartenstein, Ilka Ruschenburg, Ralf Paschke
BACKGROUND: Major differences with respect to the diagnostic performance of a "ruling in" approach in the pre-surgical diagnosis of indeterminate thyroid fine needle aspirations (FNAs) have been reported. Therefore, the aim of this prospective multicenter study was to investigate the specific diagnostic impact of mutation testing using a 7-gene-panel in a routine primary referral setting analyzing FNAs from endocrinology and nuclear medicine practices in Germany. METHODS: RNA and DNA was extracted from 564 routine air-dried FNA smears obtained from 64 physicians and cytologically graded by one experienced cytopathologist...
January 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28064410/detecting-n-ras-q61r-mutated-thyroid-neoplasias-by-immunohistochemistry
#17
A Crescenzi, F Fulciniti, M Bongiovanni, L Giovanella, Pierpaolo Trimboli
Recently, the immunohistochemistry (IHC) for N-RAS Q61R has been developed and commercialized for clinical practice. Here, we investigated the reliability of IHC to identify N-RAS Q61R mutated thyroid neoplasia. A series of 24 consecutive thyroid lesions undergone surgery following indeterminate cytology were enrolled. Paraffin sections were stained for IHC using the rabbit monoclonal anti-human N-RAS Q61R, clone SP174. N-RAS mutations in codon 61 were also investigated by automated sequencing. At histology, 12 cases of follicular carcinoma, cytologically defined as follicular lesions, 1 papillary cancer, 7 follicular adenomas, and 4 hyperplastic nodules were found...
January 7, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28061868/mir-221-a-potential-prognostic-biomarker-for-recurrence-in-papillary-thyroid-cancer
#18
Lei Dai, Yaozong Wang, Liangliang Chen, Jueru Zheng, Jianjun Li, Xianjiang Wu
BACKGROUND: Many studies have reported several transcriptionally deregulated microRNAs (miRNAs) in papillary thyroid cancer (PTC) tissue in comparison with benign thyroid nodules and normal thyroid tissues. However, the correlation between miRNA expressions and PTC recurrence still remains unclear. METHODS: The PTC patients who scheduled to undergo total thyroidectomy by the same surgical team in Ningbo NO.2 Hospital from March 1998 to March 2008 were enrolled in this study...
January 7, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28058547/effect-of-thyroid-remnant-volume-on-the-risk-of-hypothyroidism-after-hemithyroidectomy-a-prospective-study
#19
Brian Hung-Hin Lang, Carlos K H Wong, Kai Pun Wong, Kelvin Ka-Wan Chu, Tony W H Shek
BACKGROUND: Hypothyroidism is a common sequel after a hemithyroidectomy. Although various risk factors leading to hypothyroidism have been reported, the effect of the contralateral lobe's volume has been understudied. This study aimed to examine the association between the preoperative contralateral lobe's volume and the risk of postoperative hypothyroidism. METHODS: During a 2-year period, 150 eligible patients undergoing a hemithyroidectomy were evaluated. The volume of the contralateral nonexcised lobe was estimated preoperatively by independent assessors on ultrasonography using the following formula: width (in cm) × depth (in cm) × length (in cm) × (π/6), adjusted for the body surface area (BSA)...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28057295/are-large-thyroid-nodules-classified-as-benign-on-fine-needle-aspiration-more-likely-to-harbor-cancer
#20
Helen Shi, Iulianna Bobanga, Christopher R McHenry
INTRODUCTION: Our aim was to investigate whether benign thyroid nodules ≥ 4 cm have a higher malignancy rate. METHODS: A retrospective review of patients with a nodule and a benign FNAB who underwent thyroidectomy was completed. Patients were divided into two groups; nodule size: < 4 cm or ≥4 cm, and clinical factors, nodule size and rates of malignancy were compared. RESULTS: 337 patients underwent thyroidectomy: 99 had nodules <4 cm (2...
December 28, 2016: American Journal of Surgery
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