keyword
https://read.qxmd.com/read/38546792/efficacy-of-microwave-ablation-in-the-treatment-of-large-benign-thyroid-nodules-a-multi-center-study
#1
JOURNAL ARTICLE
Yuan-Cheng Cang, Fang-Ying Fan, Yang Liu, Jian-Ming Li, Chuan Pang, Dong Xu, Ying Che, Chun-Lai Zhang, Gang Dong, Ping Liang, Jie Yu, Lei Chen
OBJECTIVE: To evaluate the efficacy, safety, and improvement of symptoms by ultrasound-guided microwave ablation (MWA) for patients with large benign thyroid nodules (BTNs). METHODS: Eighty-seven patients with 87 BTNs (≥ 4 cm) treated with MWA between April 2015 and March 2021 were enrolled in this retrospective multicenter study, with clinical and ultrasound examinations performed at the 1st, 3rd, 6th, and 12th months. A multivariable linear mixed effects model was employed to explore the alterations in volume and volume reduction ratio (VRR), as well as the potential factors associated with VRR...
March 28, 2024: European Radiology
https://read.qxmd.com/read/38544987/effect-of-comprehensive-nursing-intervention-on-the-quality-of-life-and-clinical-outcomes-of-patients-with-thyroid-nodules-treated-by-ultrasound-guided-microwave-ablation
#2
JOURNAL ARTICLE
Dan Chen, Fan Yang, Shao-Ling Xing, Chun-Zi Liu
OBJECTIVE: To evaluate the effects of comprehensive nursing intervention on the quality of life and clinical outcomes of patients with thyroid nodules treated by ultrasound-guided microwave ablation. METHODS: This was a prospective study conducted from December 2020 to December 2022 at The Fifth Medical Center of Chinese PLA General Hospital. One hundred and twenty patients with benign thyroid nodules undergoing microwave ablation were included. Patients were randomly divided into control group and experimental group...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38544658/sensitivity-and-specificity-analysis-of-fine-needle-aspiration-cytology-fnac-for-thyroid-swelling
#3
JOURNAL ARTICLE
Mangesh G Kohale, Anupama V Dhobale, Nandkishor J Bankar, Neha Bhatt, Akshay H Salgar
Introduction Thyroid gland disorders, such as goiters or tumor masses, are the result of localized or systemic aberrations of the thyroid gland. The purpose of this research was to see how effective fine needle aspiration cytology (FNAC) was in detecting thyroid swelling in patients with thyroid swelling. It is critical to be able to differentiate between benign and malignant thyroid nodules to reduce unnecessary thyroid surgeries. It is hypothesized that FNAC is not a reliable diagnostic tool to detect thyroid nodules in patients with thyroid swelling and that there is a significant variation between the number of thyroid nodules detected by FNAC and the number of thyroid nodules that were eventually diagnosed as malignant by surgery...
February 2024: Curēus
https://read.qxmd.com/read/38544601/high-malignancy-risk-and-its-predictors-in-south-indian-patients-with-bethesda-ii-thyroid-nodules
#4
JOURNAL ARTICLE
Sunanda Tirupati, Pradeep Puthenveetil, Shilpa Lakkundi, Anudeep Gaddam, Vijaya Sarathi
BACKGROUND: Global data reports a low malignancy risk, whereas regional data report a variable risk of malignancy in Bethesda II thyroid nodules. The limited availability of surgical histopathology might have underestimated the risk of malignancy. Here, we report the prevalence of malignancy and its predictors in Bethesda II thyroid nodules for which the surgical histopathological diagnosis was available. METHODS:  This retrospective study was done at a tertiary healthcare center in South India between January 2008 and September 2015...
February 2024: Curēus
https://read.qxmd.com/read/38542465/metabolic-profiles-and-blood-biomarkers-to-discriminate-between-benign-thyroid-nodules-and-papillary-carcinoma-based-on-uhplc-qtof-esi-ms-analysis
#5
JOURNAL ARTICLE
Gabriela Maria Berinde, Andreea Iulia Socaciu, Mihai Adrian Socaciu, Gabriel Emil Petre, Carmen Socaciu, Doina Piciu
In this study, serum metabolic profiling of patients diagnosed with papillary thyroid carcinoma (PTC) and benign thyroid pathologies (BT) aimed to identify specific biomarkers and altered pathways when compared with healthy controls (C). The blood was collected after a histological confirmation from PTC (n = 24) and BT patients (n = 31) in parallel with healthy controls (n = 81). The untargeted metabolomics protocol was applied by UHPLC-QTOF-ESI+ -MS analysis and the statistical analysis was performed using the MetaboAnalyst 5...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541982/current-state-of-molecular-cytology-in-thyroid-nodules-platforms-and-their-diagnostic-and-theranostic-utility
#6
REVIEW
Zeina C Hannoush, Roberto Ruiz-Cordero, Mark Jara, Atil Y Kargi
The high prevalence of thyroid nodules and increased availability of neck ultrasound have led to an increased incidence of diagnostic thyroid fine needle aspirations, with approximately 20% yielding indeterminate results. The recent availability of molecular tests has helped guide the clinical management of these cases. This paper aims to review and compare three main commercially available molecular cytology platforms in the U.S.-Afirma GSC, Thyroseq GC, and ThyGeNEXT + ThyraMIR. Sequential improvements of the Afirma GSC and Thyroseq GC tests have increased positive and negative predictive values, sensitivity, and specificity...
March 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38539143/the-value-of-a-neural-network-based-on-multi-scale-feature-fusion-to-ultrasound-images-for-the-differentiation-in-thyroid-follicular-neoplasms
#7
JOURNAL ARTICLE
Weiwei Chen, Xuejun Ni, Cheng Qian, Lei Yang, Zheng Zhang, Mengdan Li, Fanlei Kong, Mengqin Huang, Maosheng He, Yifei Yin
OBJECTIVE: The objective of this research was to create a deep learning network that utilizes multiscale images for the classification of follicular thyroid carcinoma (FTC) and follicular thyroid adenoma (FTA) through preoperative US. METHODS: This retrospective study involved the collection of ultrasound images from 279 patients at two tertiary level hospitals. To address the issue of false positives caused by small nodules, we introduced a multi-rescale fusion network (MRF-Net)...
March 27, 2024: BMC Medical Imaging
https://read.qxmd.com/read/38537188/multimodal-ultrasonography-evaluation-in-thyroid-nodule-characterization-what-is-the-ideal-algorithm
#8
JOURNAL ARTICLE
Başak Erdemli Gürsel, Barış Çağlar, Rıfat Özpar, Özlem Saraydaroğlu, Gökhan Gökalp, Naile Bolca Topal
AIMS: The aim of this study is to investigate the diagnostic performances of Ultrasonography (US), Shear-wave Elastography (SWE), and Superb Microvascular Imaging (SMI) findings in the diagnosis of malignant thyroid nodules (MTNs) and to determine the US algorithm with the best diagnostic performance. MATERIAL AND METHODS: Eighty-one nodules in 77 patients who had underwent multimodal US with biopsy results, were evaluated. Echogenicity, nodule components, contours, presence and type of calcification, and size were analyzed with US...
March 27, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38536643/a-systematic-review-of-machine-learning-based-thyroid-tumor-characterisation-using-ultrasonographic-images
#9
REVIEW
Niranjan Yadav, Rajeshwar Dass, Jitendra Virmani
Ultrasonography is widely used to screen thyroid tumors because it is safe, easy to use, and low-cost. However, it is simultaneously affected by speckle noise and other artifacts, so early detection of thyroid abnormalities becomes difficult for the radiologist. Therefore, various researchers continuously address the limitations of sonography and improve the diagnosis potential of US images for thyroid tissue from the last three decays. Accordingly, the present study extensively reviewed various CAD systems used to classify thyroid tumor US (TTUS) images related to datasets, despeckling algorithms, segmentation algorithms, feature extraction and selection, assessment parameters, and classification algorithms...
March 27, 2024: Journal of Ultrasound
https://read.qxmd.com/read/38534046/the-late-effects-of-haematopoietic-stem-cell-transplants-in-paediatric-patients-a-25-year-review
#10
JOURNAL ARTICLE
Samantha Lai-Ka Lee, Quynh-Nhu Nguyen, Cindy Ho, Simon James, Amreeta Kaur, Angelina Lim, Karin Tiedemann, Margaret Zacharin
CONTEXT: A rare, large single centre study covering all long-term health outcomes of paediatric allogeneic HSCT survivors, to provide comprehensive local data, and identify gaps and future directions for improved care. OBJECTIVE: To document endocrine sequelae and other late effects of all HSCT recipients. DESIGN: Retrospective review. SETTING: Royal Children's Hospital Melbourne. PATIENTS: 384 children and adolescents received HSCT...
March 27, 2024: Journal of Clinical Endocrinology and Metabolism
https://read.qxmd.com/read/38533287/role-of-genetic-testing-in-the-management-of-indeterminate-thyroid-nodules-in-the-indian-setting
#11
REVIEW
Jeyashanth Riju, Nihal Thomas, Thomas V Paul, Deepak Thomas Abraham, Rekha Pai, Anne J Prabhu, Paul Mazhuvanchary Jacob, Remya Rajan, Rajiv C Michael, Amit Jiwan Tirkey, Natarajan Ramalingam, Hesarghatta S Asha, Nitin Kapoor
The increased detection of thyroid nodules in the human population has led to an increase in the number of thyroid surgeries without an improvement in survival outcomes. Though the choice for surgery is straightforward in malignant thyroid nodules, the decision is far more complex in those nodules that get categorized into indeterminate thyroid nodules (ITN) by fine needle aspiration. Therefore, there is a pressing need to develop a tool that will aid in decision-making among the ITN. In this context, the development of various molecular testing (MT) panels has helped to confirm or rule out malignancy, reducing unnecessary surgeries and potentially guiding the extent of surgery as well...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532782/identification-of-a-novel-non-v600e-braf-mutation-in-papillary-thyroid-cancer
#12
Marco Capezzone, Maja Rossi, Elisabetta Macerola, Silvia Cantara, Francesco Pepe, Eugenia Maria Morabito, Gilda Dalmazio, Sara Bardi, Agostino Ognibene, Massimo Alessandri, Gabriele Materazzi, Luigi De Napoli, Michele Cirianni, Liborio Torregrossa
Papillary thyroid cancer (PTC) is a common endocrine malignancy, and its incidence is reported to be constantly increasing. BRAF mutation is detected in approximately 44% of PTCs, and the most common BRAF mutation is thymine (T) to adenine (A) missense mutation in nucleotide 1796 (T1796A, V600E). Although BRAFV600E represents 95% of all BRAF mutations, uncommon BRAF mutations have been reported in thyroid carcinomas and represent an alternative mechanism of BRAF activation with unclear clinical significance...
2024: Case Reports in Endocrinology
https://read.qxmd.com/read/38532506/sonographic-characteristics-of-diffuse-sclerosing-variant-of-papillary-thyroid-carcinoma-with-histopathological-correlation-a-preliminary-study
#13
JOURNAL ARTICLE
Wanying Li, Ying Wang, Luying Gao, Ruie Feng, Ke Lv, Xining Wu, Xiao Yang, Sheng Cai, Hongyan Wang, Jianchu Li
BACKGROUND: Diffuse sclerosing variant of papillary thyroid carcinoma (DSVPTC) is a rare but high invasive subtype of papillary thyroid carcinoma, which mandates an aggressive clinical strategy. Few studies have focused on the sonographic characteristics of DSVPTC and the role of ultrasound in diagnosis and treatment of this variant remains unknown. This study aimed to identify and understand DSVPTC more accurately under ultrasound in correlation with pathology. METHODS: The ultrasound characteristics and histopathologic sections of 10 lesions in 10 DSVPTC patients who underwent thyroid surgery at our center between 2014 and 2020 were reviewed and compared with 184 lesions in 168 classic variant of papillary thyroid carcinoma (cPTC) patients...
March 26, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38528686/establishment-and-preliminary-application-of-personalized-three-dimensional-reconstruction-of-thyroid-gland-with-automatic-detection-of-thyroid-nodules-based-on-ultrasound-videos
#14
JOURNAL ARTICLE
Huang Yandong, Zhang Shiqi, Jia Lanting, Hu Wenxin, Chen Leyao, Huang Hejing
PURPOSE: A well display of the spatial location of thyroid nodules in the thyroid is important for surgical path planning and surgeon-patient communication. The aim of this study was to establish a three-dimensional (3D) reconstruction method of the thyroid gland, thyroid nodule, and carotid artery with automatic detection based on two-dimensional (2D) ultrasound videos, and to evaluate its clinical value. METHODS: Ultrasound videos, including the thyroid gland with nodule, isthmus of thyroid gland, and ipsilateral carotid artery, were recorded...
March 25, 2024: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/38524833/pulmonary-adenocarcinoma-in-situ-with-morule-like-components-a-surgical-case-report
#15
Mitsuteru Yosida, Mitsuru Tomita, Naoya Kawakita, Teruki Shimizu, Ryou Yamada, Hiromitsu Takizawa, Hisanori Uehara
Unusual lung adenocarcinoma with morule-like components is characterized by uniform, tightly packed spindle-shaped cells filling the lumens of neoplastic glandular structures. We present a case of a 78-year-old woman who presented with a part-solid ground-glass nodule in the upper lobe of the right lung. Following right upper lobectomy, histological examination revealed adenocarcinoma in-situ with multiple morule-like intra-alveolar proliferative nests of epithelial cells. Immunostaining was positive for thyroid-transcription factor 1 in the tumor cells and morule-like components...
2024: Respiratory Medicine Case Reports
https://read.qxmd.com/read/38524065/thyroidectomy-effects-on-the-body-mass-index-and-thyroid-stimulating-hormone-a-systematic-review-and-meta-analysis
#16
REVIEW
Hyder Mirghani, Ahmad M Fnjan, Abdullah F Almalki, Ali F Almadan, Omar Abdullah M Alammar, Abdulaziz S Alhwiati, Amer A Laradhi, Ahmed M Bakour, Mohamad A Aljahed, Abdulmajeed M Alzahrani
Thyroidectomy is common and is performed for malignancy, goiters with pressure symptoms, and certain types of Grave's disease. Weight and body mass index (BMI) following thyroidectomy were discussed controversially. This meta-analysis aimed to assess weight and BMI following thyroidectomy. A systematic literature search was conducted in PubMed, Medline, and Google Scholar with interest in articles that assessed body weight and BMI following total or subtotal thyroidectomy. The search engine was limited to the period from inception up to January 2024...
February 2024: Curēus
https://read.qxmd.com/read/38523848/a-rare-case-of-persistent-multifocal-cribriform-morular-thyroid-carcinoma
#17
William Kuenstner, Po Zhao, Wen Lee, Carlos Garcia, Kenneth D Burman, Leila Shobab
BACKGROUND/OBJECTIVE: Cribriform-morular thyroid carcinoma (CMTC) was considered a variant of papillary thyroid carcinoma (PTC) but is a separate entity in the 2022 World Health Organization classification. CMTC has an association with familial adenomatous polyposis (FAP). Our objective is to report a case of CMTC who was subsequently diagnosed with FAP, to highlight these associated entities and implications for management. CASE REPORT: A 15-year-old female with a history of iron-deficiency anemia and alpha-gal syndrome presented with several years of goiter and dysphagia...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38523345/assessment-of-thyroid-gland-in-children-with-point-of-care-ultrasound-pocus-radiological-performance-and-feasibility-of-handheld-ultrasound-in-clinical-practice
#18
JOURNAL ARTICLE
Ahmet Anık, Mustafa Gök, Göksel Tuzcu
BACKGROUND: Point-of-Care Ultrasound (POCUS) refers to the use of portable ultrasound machines to perform quick and focused ultrasound examinations at a patient's bedside or point-of-care. POCUS can be performed by all health workers with specific training to use POCUS. This study aimed to investigate the radiological performance and feasibility of POCUS using a handheld ultrasound (HHUSD) system in children from the perspective of the thyroid gland perspective. MATERIAL-METHODS: A pediatric endocrinologist performed thyroid imaging in children referred to our hospital with suspected thyroid disease using an HHUSD system...
March 25, 2024: Journal of Clinical Research in Pediatric Endocrinology
https://read.qxmd.com/read/38522825/effect-of-music-therapy-on-pain-during-thyroid-fine-needle-aspiration-biopsy-a-randomized-controlled-clinical-trial
#19
JOURNAL ARTICLE
Burcak Cavnar Helvaci, Sefika Burcak Polat, Belma Tural Balsak, Nagihan Bestepe, Oya Topaloglu, Reyhan Ersoy, Bekir Cakir
INTRODUCTION: High-resolution ultrasonography devices have led to the increased detection of thyroid nodules and the need for fine-needle aspiration biopsy (FNAB). However, FNAB is an invasive procedure that can cause discomfort and pain. Music therapy has been used for centuries to alleviate pain, and our clinical trial was conducted to investigate its impact on pain scores during thyroid FNAB. MATERIALS AND METHODS: We conducted a randomized, controlled clinical trial, including adult patients undergoing thyroid FNAB...
March 22, 2024: Endocrine Practice
https://read.qxmd.com/read/38522359/evaluation-of-the-follicular-patterned-thyroid-lesions-based-on-the-who-2022-criteria-with-an-emphasis-on-the-grey-zone-lesions
#20
JOURNAL ARTICLE
Sunayana Misra, Shashi Dhawan, Sonia Badwal, Arupparna Sengupta, Aanchal Khosla, Sangeet Kumar Agarwal, Seema Rao
Follicular-patterned thyroid nodules (FPTN) are classified byWHO-2022 into benign, borderline and malignant categories. There are however, grey-zone lesions that pose a diagnostic challenge due to ambiguity in defining criteria and inter-observer variability. WHO-2022 has enumerated specific diagnostic criteria for these lesions. Accurate categorization of morphologically similar TNs is vital to reduce overtreatment of indolent lesions. In this study, we have reclassified FPTNs according to WHO-2022 criteria, emphasizing on grey-zone lesions...
February 14, 2024: Annals of Diagnostic Pathology
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