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https://www.readbyqxmd.com/read/30359426/the-minor-gentamicin-complex-component-x2-is-a-potent-premature-stop-codon-readthrough-molecule-with-therapeutic-potential
#1
Westley J Friesen, Briana Johnson, Jairo Sierra, Jin Zhuo, Priya Vazirani, Xiaojiao Xue, Yuki Tomizawa, Ramil Baiazitov, Christie Morrill, Hongyu Ren, Suresh Babu, Young-Choon Moon, Art Branstrom, Anna Mollin, Jean Hedrick, Josephine Sheedy, Gary Elfring, Marla Weetall, Joseph M Colacino, Ellen M Welch, Stuart W Peltz
Nonsense mutations, resulting in a premature stop codon in the open reading frame of mRNAs are responsible for thousands of inherited diseases. Readthrough of premature stop codons by small molecule drugs has emerged as a promising therapeutic approach to treat disorders resulting from premature termination of translation. The aminoglycoside antibiotics are a class of molecule known to promote readthrough at premature termination codons. Gentamicin consists of a mixture of major and minor aminoglycoside components...
2018: PloS One
https://www.readbyqxmd.com/read/30344402/comparison-of-efficacy-of-halstead-vazirani-akinosi-and-gow-gates-techniques-for-mandibular-anesthesia
#2
B Sarat Ravi Kiran, Vinay M Kashyap, Uday Kiran Uppada, Prabhat Tiwari, Ashank Mishra, Akanksha Sachdeva
Purpose: Traditionally, the "Halstead block" has been widely used to provide anesthesia in mandibular teeth. Two other techniques, the Gow Gates mandibular nerve block and the Akinosi Vazirani closed-mouth mandibular nerve block, are reliable alternatives to the conventional inferior alveolar nerve block. The purpose of this study is to evaluate the onset of anesthesia, anesthetic success and incidence of positive aspiration during administration of local anesthetic solution using the Halstead, Vazirani Akinosi and Gow Gates techniques...
December 2018: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/30314107/copelatus-erichson-1832-from-maharashtra-india-with-description-of-three-new-species-and-notes-on-other-taxa-of-the-genus-coleoptera-dytiscidae-copelatinae
#3
Sayali D Sheth, Hemant V Ghate, JiŘÍ HÁjek
The Copelatus species occurring in Maharashtra State, India, are reviewed. Altogether, nine species are recorded, three of which are described as new: Copelatus deccanensis sp. nov. (C. nigrolineatus species group), C. maushomi sp. nov. (C. consors group) and C. bezdeki sp. nov. (C. irinus group). Habitus and male genitalia are illustrated for all Copelatus species from Maharashtra, a key to the species and distribution maps are presented. New distributional records along with short diagnoses of already known species are provided...
August 15, 2018: Zootaxa
https://www.readbyqxmd.com/read/30312586/is-the-vazirani-akinosi-nerve-block-a-better-technique-than-the-conventional-inferior-alveolar-nerve-block-for-beginners
#4
Komagan Prabhu Nakkeeran, Poornima Ravi, Guruprasad Thulasi Doss, Krishna Kumar Raja
PURPOSE: This study was performed to compare the efficacy and comfort of the inferior alveolar nerve (IAN) block and the Vazirani-Akinosi (VA) nerve block when administered by dental trainees. MATERIALS AND METHODS: In this prospective, randomized controlled trial, patients requiring extraction of mandibular teeth received either the conventional IAN block (IAN group) or VA nerve block (VA group). Objective parameters evaluated included ease of locating landmarks, incidence of positive aspiration, and failure rate...
September 18, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30277303/outcomes-following-resection-of-non-small-cell-lung-cancer-in-octogenarians
#5
Jaideep Vazirani, Johanna Moraes, Stephen Barnett, Douglas F Johnson, Simon Knight, Alistair Miller, Gavin Wright, Naveed Z Alam, Matthew Conron, Louis B Irving, Phillip Antippa, Daniel P Steinfort
BACKGROUND: The treatment of choice for early stage non-small cell lung cancer (NSCLC) is surgical resection. Little is known about the short- and long-term outcomes among very elderly patients. We sought to determine predictors of short- and long-term survival among octogenarians undergoing curative-intent resection for NSCLC in Victoria, Australia. METHODS: We retrospectively reviewed data from all patients aged ≥80 years who underwent curative-intent resection for NSCLC over 12 years (January 2005-December 2016) across five tertiary centres...
October 2, 2018: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/30181243/oncogenic-ras-isoforms-show-a-hierarchical-requirement-for-the-guanine-nucleotide-exchange-factor-sos2-to-mediate-cell-transformation
#6
Erin Sheffels, Nancy E Sealover, Chenyue Wang, Do Hyung Kim, Isabella A Vazirani, Elizabeth Lee, Elizabeth M Terrell, Deborah K Morrison, Ji Luo, Robert L Kortum
About a third of tumors have activating mutations in HRAS , NRAS , or KRAS , genes encoding guanosine triphosphatases (GTPases) of the RAS family. In these tumors, wild-type RAS cooperates with mutant RAS to promote downstream effector activation and cell proliferation and transformation, suggesting that upstream activators of wild-type RAS are important modulators of mutant RAS-driven oncogenesis. The guanine nucleotide exchange factor (GEF) SOS1 mediates KRAS-driven proliferation, but little is understood about the role of SOS2...
September 4, 2018: Science Signaling
https://www.readbyqxmd.com/read/29907418/long-term-experience-with-a-mandatory-clinical-decision-rule-and-mandatory-d-dimer-in-the-evaluation-of-suspected-pulmonary-embolism
#7
Guy W Soo Hoo, Emily Tsai, Sondra Vazirani, Zhaoping Li, Bruce M Barack, Carol C Wu
PURPOSE: This study evaluated the long-term effectiveness of mandatory assignment of both a clinical decision rule (CDR) and highly sensitive d-dimer in the evaluation of patients with suspected pulmonary embolism (PE). MATERIALS AND METHODS: Institutional guidelines with a CDR and highly sensitive d-dimer were embedded in an order entry menu with mandatory assignment of key components before ordering a CT pulmonary angiogram (CTPA). Data were retrospectively extracted from the electronic health record...
June 12, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29850021/a-complicated-cockroach-ectomy
#8
Jaideep Vazirani, Christiaan Yu, Robert Stirling
The exact incidence of foreign body aspiration among adults is unknown, and its clinical presentation is vastly divergent. We report the previously undescribed occurrence of cockroach aspiration in an adult, presenting with a "crawling sensation" in his chest. Flexible endobronchial examination revealed a foreign body impacted in the lingula, resembling the Australian cockroach Periplaneta australasiae. Partial extraction via biopsy forceps was performed and complicated by acute hypoxia on disimpaction, requiring a brief period of bag/mask ventilation...
August 2018: Respirology Case Reports
https://www.readbyqxmd.com/read/29661963/obesity-suppresses-tumor-attributable-psa-affecting-risk-categorization
#9
Ken Chow, Stefano Mangiola, Jaideep Vazirani, Justin S Peters, Anthony J Costello, Christopher M Hovens, Niall M Corcoran
Obesity is linked with more aggressive prostate cancer and higher rates of disease recurrence post treatment. It is unclear if this is due to specific tumor-promoting effects of obesity or diagnostic bias. Patients undergoing prostatectomy were categorized according to their body mass index (BMI). Expected prostate-specific antigen (PSA) levels were calculated for each patient based on tumor characteristics. The effect of obesity on the accuracy of pre-treatment risk categorization was determined, and mediation analysis was used to identify the contribution of biologic vs non-biologic mechanisms to the observed increased risk of biochemical recurrence...
May 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29503779/fractionated-radiosurgery-alone-for-thirty-seven-brain-metastases-not-everything-that-can-be-counted-counts
#10
Christian Hyde, Shannon Kinser, Christopher Croft, Patricia Schantz, Kayla Brown, Rajendra Vazirani, Jikun Wei, Ioana Bonta
There is an ongoing debate as to the maximum number of brain metastases that can safely and practically be treated with a single course of radiosurgery. Despite evidence of durable local control and favorable overall survival when treating 10 or more brain metastases with radiosurgery alone, some institutions and guidelines still limit radiosurgery to an arbitrary number of metastases. As demonstrated by this case report, the number of lesions is not so important when the patient's life expectancy is otherwise good and body tumors are controllable...
December 25, 2017: Curēus
https://www.readbyqxmd.com/read/29378178/limbal-stem-cell-deficiency-demography-and-underlying-causes
#11
Jayesh Vazirani, Dhanyasree Nair, Swapna Shanbhag, Siva Wurity, Abhishek Ranjan, Virender Sangwan
PURPOSE: To determine the demographic features of patients affected by limbal stem cell deficiency (LSCD), and to identify the underlying causes of LSCD. DESIGN: Retrospective, multicenter case series. SETTING: Two large tertiary care ophthalmology hospitals. SUBJECTS: Patients with a diagnosis of LSCD presenting from January 1, 2005 to December 31, 2014. METHODS: Records of patients with a clinical diagnosis of LSCD were reviewed...
April 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29305345/corneal-endothelial-alterations-in-alcohol-dependence-syndrome
#12
Alok Sati, Parthasarathi Moulick, Sandeep Shankar, Kaushik Chatterjee, Arun Kumar Dwivedi, Jayesh Vazirani
BACKGROUND/AIMS: To evaluate the corneal endothelial changes in patients with alcohol dependence syndrome (ADS). METHODS: A total of 322 corneas of 322 subjects were studied, and two groups were formed. The first, the ADS group, included 161 corneas of 161 patients and the second, the age-matched control group, was composed of 161 corneas of 161 healthy subjects. Both the groups were examined by specular microscope and the endothelial parameters were compared. The endothelial parameters were also compared before and after the abstinence of alcohol in the former group...
January 5, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29283121/ocular-surface-inflammation-in-dry-eye-disease-what-we-know-and-what-we-do-not
#13
COMMENT
Jayesh Vazirani
No abstract text is available yet for this article.
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29202126/the-role-of-sex-work-pay-in-moderating-the-effect-of-mobile-phone-solicitation-on-condom-practices-an-analysis-of-female-sex-workers-in-india
#14
S Navani-Vazirani, E Heylen, J Deardorff, A K Srikrishnan, C K Vasudevan, D Solomon, M L Ekstrand
Mobile phones remain a largely untapped resource in the ongoing challenge to address Female Sex Worker (FSW) health, including HIV prevention services, in India. An important step towards designing effective mobile phone-based initiatives for FSWs is clarifying the contextual influences of mobile phone solicitation on sexual risk behavior. In this paper, we extend previously identified associations between mobile phone solicitation and condom practices by examining whether this association is moderated by sex work pay and offer key considerations for future research and implementation...
2017: HSOA Journal of AIDS Clinical Research & STDs
https://www.readbyqxmd.com/read/29069585/absence-of-carbohydrate-response-element-binding-protein-in-adipocytes-causes-systemic-insulin-resistance-and-impairs-glucose-transport
#15
Archana Vijayakumar, Pratik Aryal, Jennifer Wen, Ismail Syed, Reema P Vazirani, Pedro M Moraes-Vieira, Joao Paulo Camporez, Molly R Gallop, Rachel J Perry, Odile D Peroni, Gerald I Shulman, Alan Saghatelian, Timothy E McGraw, Barbara B Kahn
Lower adipose-ChREBP and de novo lipogenesis (DNL) are associated with insulin resistance in humans. Here, we generated adipose-specific ChREBP knockout (AdChREBP KO) mice with negligible sucrose-induced DNL in adipose tissue (AT). Chow-fed AdChREBP KO mice are insulin resistant with impaired insulin action in the liver, muscle, and AT and increased AT inflammation. HFD-fed AdChREBP KO mice are also more insulin resistant than controls. Surprisingly, adipocytes lacking ChREBP display a cell-autonomous reduction in insulin-stimulated glucose transport that is mediated by impaired Glut4 translocation and exocytosis, not lower Glut4 levels...
October 24, 2017: Cell Reports
https://www.readbyqxmd.com/read/28523090/penetrating-craniomaxillofacial-injury-caused-by-a-pneumatic-nail-gun
#16
Kevin Jae Choi, Marisa Ann Ryan, Tracy Cheng, David Powers
Craniomaxillofacial injuries can be complex, requiring a multidisciplinary approach. The primary survey is always the first step in trauma management prior to proceeding with further evaluation and treatment. A 26-year-old man presented with a penetrating nail gun injury through the oral and nasal cavities. He did not present in extremis but required elective endotracheal intubation for intraoperative assessment and treatment. Airway management was enhanced by the use of lingual nerve and inferior alveolar nerve blocks via the Vazirani-Akinosi technique to maintain spontaneous respiration while the tongue was distracted from the palate...
June 2017: Craniomaxillofacial Trauma & Reconstruction
https://www.readbyqxmd.com/read/28346540/fragment-library-screening-identifies-hits-that-bind-to-the-non-catalytic-surface-of-pseudomonas-aeruginosa-dsba1
#17
Biswaranjan Mohanty, Kieran Rimmer, Róisín M McMahon, Stephen J Headey, Mansha Vazirani, Stephen R Shouldice, Mathieu Coinçon, Stephanie Tay, Craig J Morton, Jamie S Simpson, Jennifer L Martin, Martin J Scanlon
At a time when the antibiotic drug discovery pipeline has stalled, antibiotic resistance is accelerating with catastrophic implications for our ability to treat bacterial infections. Globally we face the prospect of a future when common infections can once again kill. Anti-virulence approaches that target the capacity of the bacterium to cause disease rather than the growth or survival of the bacterium itself offer a tantalizing prospect of novel antimicrobials. They may also reduce the propensity to induce resistance by removing the strong selection pressure imparted by bactericidal or bacteriostatic agents...
2017: PloS One
https://www.readbyqxmd.com/read/28106160/evaluation-of-three-block-anesthesia-methods-for-pain-management-during-mandibular-third-molar-extraction-a-meta-analysis
#18
REVIEW
Fanyuan Yu, Yao Xiao, Hanghang Liu, Fanzi Wu, Feng Lou, Dian Chen, Mingru Bai, Dingming Huang, Chenglin Wang, Ling Ye
A patient's pain during mandibular third molar extraction often creates problems for a dental surgeon and can also cause immense patient discomfort, such as decreased quality of life, serious complications, or even danger to the patients' lives. Effective pain management is therefore of great importance. Conventional block anesthesia method often fails to control such pain completely during an operation. Therefore, two available alternatives, Gow-Gates (G-G) and Vazirani-Akinosi (V-A) methods, have been developed...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27982660/randomness-amplification-under-minimal-fundamental-assumptions-on-the-devices
#19
Ravishankar Ramanathan, Fernando G S L Brandão, Karol Horodecki, Michał Horodecki, Paweł Horodecki, Hanna Wojewódka
Recently, the physically realistic protocol amplifying the randomness of Santha-Vazirani sources producing cryptographically secure random bits was proposed; however, for reasons of practical relevance, the crucial question remained open regarding whether this can be accomplished under the minimal conditions necessary for the task. Namely, is it possible to achieve randomness amplification using only two no-signaling components and in a situation where the violation of a Bell inequality only guarantees that some outcomes of the device for specific inputs exhibit randomness? Here, we solve this question and present a device-independent protocol for randomness amplification of Santha-Vazirani sources using a device consisting of two nonsignaling components...
December 2, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27778134/determination-of-ligand-binding-modes-in-weak-protein-ligand-complexes-using-sparse-nmr-data
#20
Biswaranjan Mohanty, Martin L Williams, Bradley C Doak, Mansha Vazirani, Olga Ilyichova, Geqing Wang, Wolfgang Bermel, Jamie S Simpson, David K Chalmers, Glenn F King, Mehdi Mobli, Martin J Scanlon
We describe a general approach to determine the binding pose of small molecules in weakly bound protein-ligand complexes by deriving distance constraints between the ligand and methyl groups from all methyl-containing residues of the protein. We demonstrate that using a single sample, which can be prepared without the use of expensive precursors, it is possible to generate high-resolution data rapidly and obtain the resonance assignments of Ile, Leu, Val, Ala and Thr methyl groups using triple resonance scalar correlation data...
November 2016: Journal of Biomolecular NMR
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