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https://www.readbyqxmd.com/read/27778134/determination-of-ligand-binding-modes-in-weak-protein-ligand-complexes-using-sparse-nmr-data
#1
Biswaranjan Mohanty, Martin L Williams, Bradley C Doak, Mansha Vazirani, Olga Ilyichova, Geqing Wang, Wolfgang Bermel, Jamie S Simpson, David K Chalmers, Glenn F King, Mehdi Mobli, Martin J Scanlon
We describe a general approach to determine the binding pose of small molecules in weakly bound protein-ligand complexes by deriving distance constraints between the ligand and methyl groups from all methyl-containing residues of the protein. We demonstrate that using a single sample, which can be prepared without the use of expensive precursors, it is possible to generate high-resolution data rapidly and obtain the resonance assignments of Ile, Leu, Val, Ala and Thr methyl groups using triple resonance scalar correlation data...
October 24, 2016: Journal of Biomolecular NMR
https://www.readbyqxmd.com/read/27641620/disaster-impact-on-impoverished-area-of-us-an-inter-professional-mixed-method-study
#2
Linda H Banks, Lisa A Davenport, Meghan H Hayes, Moriah A McArthur, Stacey N Toro, Cameron E King, Hazel M Vazirani
: Introduction In the foothills of the Cumberland Mountains, in central Appalachia (a region that spans 13 states in the US), sits an economically distressed and rural community of the United States. Once a thriving coal-mining area, this region now is reported as one of the hardest places to live in the US. Southeastern Kentucky, located in a remote, rocky, mountainous area surrounded by rivers and valleys and prone to flooding, experienced a major flood in Spring 2013 causing significant damage to homes and critical infrastructure...
December 2016: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/27488798/demonstration-of-a-small-programmable-quantum-computer-with-atomic-qubits
#3
S Debnath, N M Linke, C Figgatt, K A Landsman, K Wright, C Monroe
Quantum computers can solve certain problems more efficiently than any possible conventional computer. Small quantum algorithms have been demonstrated on multiple quantum computing platforms, many specifically tailored in hardware to implement a particular algorithm or execute a limited number of computational paths. Here we demonstrate a five-qubit trapped-ion quantum computer that can be programmed in software to implement arbitrary quantum algorithms by executing any sequence of universal quantum logic gates...
August 4, 2016: Nature
https://www.readbyqxmd.com/read/27299419/specific-correction-of-alternative-survival-motor-neuron-2-splicing-by-small-molecules-discovery-of-a-potential-novel-medicine-to-treat-spinal-muscular-atrophy
#4
Hasane Ratni, Gary M Karp, Marla Weetall, Nikolai A Naryshkin, Sergey V Paushkin, Karen S Chen, Kathleen D McCarthy, Hongyan Qi, Anthony Turpoff, Matthew G Woll, Xiaoyan Zhang, Nanjing Zhang, Tianle Yang, Amal Dakka, Priya Vazirani, Xin Zhao, Emmanuel Pinard, Luke Green, Pascale David-Pierson, Dietrich Tuerck, Agnes Poirier, Wolfgang Muster, Stephan Kirchner, Lutz Mueller, Irene Gerlach, Friedrich Metzger
Spinal muscular atrophy (SMA) is the leading genetic cause of infant and toddler mortality, and there is currently no approved therapy available. SMA is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. These mutations or deletions result in low levels of functional SMN protein. SMN2, a paralogous gene to SMN1, undergoes alternative splicing and exclusion of exon 7, producing an unstable, truncated SMNΔ7 protein. Herein, we report the identification of a pyridopyrimidinone series of small molecules that modify the alternative splicing of SMN2, increasing the production of full-length SMN2 mRNA...
July 14, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27212744/efficacy-of-ultrasound-guided-mandibular-block-in-predicting-safer-anesthetic-induction
#5
Gaurav Jain, Ghanshyam Yadav, Anil Prasad Singh, Yashpal Singh, Dinesh Kumar Singh
BACKGROUND: Mandibular nerve block reverses the trismus caused by pain and muscle spasm, thereby allowing for selection of a safer intubation technique. AIMS: As ultrasonographic imaging has added newer dimensions to clinical anesthesia practice, we utilized this tool in performing mandibular nerve block and evaluated its efficacy in segregating trismus patients on etiological basis, to predict safer anesthetic induction. SETTINGS AND DESIGN: Prospective, randomized controlled, outcome assessor blinded trial...
May 2016: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/27207531/disruption-of-adipose-rab10-dependent-insulin-signaling-causes-hepatic-insulin-resistance
#6
Reema P Vazirani, Akanksha Verma, L Amanda Sadacca, Melanie S Buckman, Belen Picatoste, Muheeb Beg, Christopher Torsitano, Joanne H Bruno, Rajesh T Patel, Kotryna Simonyte, Joao P Camporez, Gabriela Moreira, Domenick J Falcone, Domenico Accili, Olivier Elemento, Gerald I Shulman, Barbara B Kahn, Timothy E McGraw
Insulin controls glucose uptake into adipose and muscle cells by regulating the amount of GLUT4 in the plasma membrane. The effect of insulin is to promote the translocation of intracellular GLUT4 to the plasma membrane. The small Rab GTPase, Rab10, is required for insulin-stimulated GLUT4 translocation in cultured 3T3-L1 adipocytes. Here we demonstrate that both insulin-stimulated glucose uptake and GLUT4 translocation to the plasma membrane are reduced by about half in adipocytes from adipose-specific Rab10 knockout (KO) mice...
June 2016: Diabetes
https://www.readbyqxmd.com/read/27151421/surgical-management-of-bilateral-limbal-stem-cell-deficiency
#7
REVIEW
Jayesh Vazirani, Indumathi Mariappan, Shreyas Ramamurthy, Saba Fatima, Sayan Basu, Virender S Sangwan
Limbal stem cell deficiency (LSCD) is now established as a distinct entity with a spectrum of clinical manifestations. Bilateral LSCD presents a unique set of challenges to the clinician dealing with ocular surface disease, due to the underlying causes, clinical presentation, and adnexal status, as well as lack of a source of autologous limbal stem cells. Various surgical modalities have been described to achieve visual rehabilitation in patients with bilateral LSCD. These can primarily be divided into cell-based therapies and implantation of keratoprostheses...
July 2016: Ocular Surface
https://www.readbyqxmd.com/read/27046246/an-unusual-rapid-response-call-malignant-catatonia
#8
Mark D Duncan, Sondra S Vazirani
No abstract text is available yet for this article.
July 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27037108/complementary-integrative-and-holistic-medicine-integrative-approaches-to-pediatric-irritable-bowel-syndrome
#9
Alycia Leiby, Minal Vazirani
No abstract text is available yet for this article.
April 2016: Pediatrics in Review
https://www.readbyqxmd.com/read/26991196/correlation-length-versus-gap-in-frustration-free-systems
#10
David Gosset, Yichen Huang
Hastings established exponential decay of correlations for ground states of gapped quantum many-body systems. A ground state of a (geometrically) local Hamiltonian with spectral gap ε has correlation length ξ upper bounded as ξ=O(1/ε). In general this bound cannot be improved. Here we study the scaling of the correlation length as a function of the spectral gap in frustration-free local Hamiltonians, and we prove a tight bound ξ=O(1/sqrt[ε]) in this setting. This highlights a fundamental difference between frustration-free and frustrated systems near criticality...
March 4, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/26976834/conjunctival-pedicle-flap-in-management-of-open-globe-injury-with-corneal-tissue-loss
#11
Nishant Nawani, Jayesh Vazirani, Hindukush Ojha, Virender S Sangwan
Accidental injury with scissors led to an open globe injury with iris prolapse and corneal tissue loss in the right eye of a 15-year-old girl. Attempts to suture the laceration normally, led to persistent aqueous leak, and tight suturing was leading to unacceptable distortion of the corneal contour. In the absence of donor tissue or tissue glue, a bulbar conjunctival pedicle flap was used to augment sutures placed without undue tension, and watertight closure of the globe was achieved. Postoperatively, the flap retracted, and excellent tectonic, cosmetic and refractive outcomes were achieved...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26967446/erratum-fully-device-independent-quantum-key-distribution-phys-rev-lett-113-140501-2014
#12
Umesh Vazirani, Thomas Vidick
This corrects the article DOI: 10.1103/PhysRevLett.113.140501.
February 26, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/26869128/ocular-surface-squamous-neoplasia
#13
Jayesh Vazirani, Samir Mohapatra
No abstract text is available yet for this article.
February 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/26817481/autologous-simple-limbal-epithelial-transplantation-for-unilateral-limbal-stem-cell-deficiency-multicentre-results
#14
Jayesh Vazirani, Mohammed Hasnat Ali, Namrata Sharma, Nidhi Gupta, Vikas Mittal, Marwan Atallah, Guillermo Amescua, Tuhin Chowdhury, Alexandra Abdala-Figuerola, Arturo Ramirez-Miranda, Alejandro Navas, Enrique O Graue-Hernández, James Chodosh
PURPOSE: To report outcomes of autologous simple limbal epithelial transplantation (SLET) performed for unilateral limbal stem cell deficiency (LSCD) at multiple centres worldwide. METHODS: In this retrospective, multicentre, interventional case series, records of patients who had undergone autologous SLET for unilateral LSCD, with a minimum of 6 months of follow-up, were reviewed. The primary outcome measure was clinical success, defined as a completely epithelised, avascular corneal surface...
October 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/26553919/efficacy-of-conjunctival-resection-with-cyanoacrylate-glue-application-in-preventing-recurrences-of-mooren-s-ulcer
#15
Ikeda Lal, Srinivas B Shivanagari, Mohammed Hasnat Ali, Jayesh Vazirani
AIM: To evaluate the role of conjunctival resection along with cyanoacrylate glue and bandage contact lens application in preventing recurrences and arresting progression in cases of Mooren's ulcer. METHOD: This retrospective interventional case series included cases of Mooren's ulcer that underwent conjunctival resection with cyanoacrylate glue and bandage contact lens application between 2011 and 2014. Systemic immunosuppression was initiated depending on the laterality and severity of disease...
November 9, 2015: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/26271698/-anatomical-rationale-for-lingual-nerve-injury-prevention-during-mandibular-block
#16
V A Semkin, S S Dydikin, A V Kuzin, V V Sogacheva
The topographic and anatomical study of lingual nerve structural features was done. It was revealed that during mandibular anesthesia possible lingual nerve injury can occur if puncture needle is lower than 1 cm. of molars occlusal surface level. The position of the lingual nerve varies withmandible movements. At the maximum open mouth lingual nerve is not mobile and is pressed against the inner surface of the mandibular ramus by the medial pterygoid muscle and the temporal muscle tendon. When closing the mouth to 1...
2015: Stomatologii︠a︡
https://www.readbyqxmd.com/read/26189185/multidrug-resistant-pseudomonas-aeruginosa-keratitis-risk-factors-clinical-characteristics-and-outcomes
#17
Jayesh Vazirani, Siva Wurity, Md Hasnat Ali
PURPOSE: To identify risk factors for multidrug-resistant Pseudomonas aeruginosa (MDR-PA) keratitis and to report clinical characteristics and outcomes of this infection. DESIGN: Retrospective, case-control study. PARTICIPANTS: Ninety episodes of P. aeruginosa keratitis from a tertiary care eye institution from 2007 through 2014 were identified. Episodes of MDR-PA keratitis were taken as cases. Episodes of drug-sensitive P. aeruginosa keratitis during the same period were taken as controls...
October 2015: Ophthalmology
https://www.readbyqxmd.com/read/26145473/-indications-feasibility-and-clinical-experience-with-vazirani-akinozi-mandibular-block-in-limiting-mouth-opening-and-difficult-anatomical-conditions
#18
A V Kuzin, V V Neledva
Vazirani-Akinozi technique was used in 82 patient undergoing oral surgery procedures. According to study results Vazirani-Akinozi technique was feasible in 89% of cases and particularly effective in surgical treatment of third lower molars eruption diseases complicated by inflammatory contracture. The method increases mouth opening 1.6-2.3 cm due to the soft-tissue anesthesia and partial anesthesia of masseter nerve. In case of inflammatory contracture of the jaws when inflammatory infiltration is spreading on the masseter muscle the authors recommend to use a combination of Vazirani-Akinozi and Berchet-Dubov techniques...
2015: Stomatologii︠a︡
https://www.readbyqxmd.com/read/26082100/customised-simple-limbal-epithelial-transplantation-for-recurrent-limbal-stem-cell-deficiency
#19
Jayesh Vazirani, Ikeda Lal, Virender Sangwan
A 4-year-old boy developed unilateral, total limbal stem cell deficiency (LSCD) following an acid injury. A stable ocular surface was achieved with autologous simple limbal epithelial transplantation (SLET), performed 4 months after the injury. Focal areas of conjunctivalisation were noted in the postoperative period. These were addressed using a novel modification of SLET. A very small piece of limbus from the healthy eye was split into multiple pieces, and applied to the bare corneal stroma with fibrin glue after pannus resection...
2015: BMJ Case Reports
https://www.readbyqxmd.com/read/26044467/reproducibility-of-retinal-nerve-fiber-layer-measurements-across-the-glaucoma-spectrum-using-optical-coherence-tomography
#20
Jayesh Vazirani, Sushmita Kaushik, Surinder Singh Pandav, Pramod Gupta
PURPOSE: The purpose was to determine intra-session and inter-session reproducibility of retinal nerve fiber layer (RNFL) thickness measurements with the spectral-domain Cirrus optical coherence tomography (OCT) ® (SD-OCT) in normal and glaucomatous eyes, including a subset of advanced glaucoma. MATERIALS AND METHODS: RNFL measurements of 40 eyes of 40 normal subjects and 40 eyes of 40 glaucomatous patients including 14 with advanced glaucoma were obtained on the Cirrus OCT ® (Carl Zeiss Meditec, Dublin, CA, USA) five times on 1-day (intra-session) and on five separate days (inter-session)...
April 2015: Indian Journal of Ophthalmology
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