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Y Liu, X Tan, Z Wang, Y Li, M Gao, Y Li, Z Fang, Y Sun, L Zhang, X Wang, Z Wei
OBJECTIVE: Adenomyosis is a common benign gynecological disease which has some malignant behaviors. Programmed cell death 4 (PDCD4) is a newly identified tumor suppressor gene which lowly expresses in various cancers. However, the expression status of PDCD4 in endometrium of adenomyosis patients has not been investigated. The aim of this study is to assess the expression levels of PDCD4 in endometrium of normal controls and adenomyosis patients. METHODS: The expression of PDCD4 in endometrium of normal controls and eutopic or ectopic endometrium of patients with adenomyosis was evaluated with quantitative real-time PCR, western blot and immunohistochemistry...
July 2016: Current Research in Translational Medicine
A J Korzekwa, M Łupicka, B M Socha, A A Szczepańska
Adenomyosis is defined as the presence of glandular foci external to the endometrium of the uterus, either in the myometrium or/and perimetrium, depending on the progress of this dysfunction. To date, we showed that steroids secretion and prolactin expression and proliferative processes are disturbed during uterine adenomyosis in cows. During endometriosis in eutopic endometrium in women, gap junctions are down regulated. The transmembrane gap junction protein, connexin (Cx43) is necessary for endometrial morphological, biochemical and angiogenic functions...
September 1, 2016: Polish Journal of Veterinary Sciences
M R Orazov, E N Nosenko, V E Radzinsky, M B Khamoshina, M G Lebedeva, M A Sounov
AIM: The study of peculiarities of expression of vascular endothelial growth factor (VEGF) in the tissues of the endometrium and myometrium in patients with adenomyosis, associated with chronic pelvic pain syndrome. MATERIALS AND METHODS: Uterus macro-preparations obtained after hysterectomy in 60 patients with pelvic pain on a background of diffuse adenomyosis II-III degree were used for morphological examination, and macro-preparations received from 30 women with adenomyosis without pain syndrome...
October 2016: Gynecological Endocrinology
V E Radzinsky, M B Khamoshina, E N Nosenko, A O Dukhin, M A Sojunov, A A Orazmuradov, M G Lebedeva, M R Orazov
OBJECTIVE: To observe the effects of levonorgestrel-releasing intrauterine system (LNG-IUS) in treatment of chronic pelvic pain associated with adenomyosis (AM) and in prevention of its recurrence. METHODS: A prospective continuing study including 180 patients with chronic pelvic pain associated with AM who received insertion of LNG-IUS who were divided into three groups depending on the pain severity. The visual analog scale (VAS) was used for pain assessment before and during the treatment and transvaginal ultrasonic measurement of the uterine size, while various side effects, were observed and recorded...
October 2016: Gynecological Endocrinology
Amy S Joehlin-Price, Kelsey E McHugh, Julie A Stephens, Zaibo Li, Floor J Backes, David E Cohn, David W Cohen, Adrian A Suarez
MELF invasion has been associated with nonvaginal recurrences and lymph node (LN) metastases in multi-institutional case control studies but has not been well examined in large single-institution cohorts. Hysterectomy specimens with FIGO 1 endometrioid endometrial carcinoma and lymphadenectomies from 2007 to 2012 were identified. Electronic medical records and histologic slides were reviewed. Of 464 identified cases, 163 (35.1%) were noninvasive, 60 (12.9%) had MELF, 222 (47.8%) had a component of the infiltrative invasion pattern without MELF, 13 (2...
October 12, 2016: American Journal of Surgical Pathology
Bo Zhu, Yumei Chen, Xiaolu Shen, Xishi Liu, Sun-Wei Guo
BACKGROUND: Recently emerging evidence indicates that endometriotic lesions are wounds undergoing repeated tissue injury and repair (ReTIAR), and platelets induce epithelial-mesenchymal transition (EMT), fibroblast-to-myofibroblast transdifferentiation (FMT), leading ultimately to fibrosis. Due to the commonality of cyclic bleeding as in endometriosis, adenomyotic lesions are also wounds that undergo ReTIAR, and we have recently provided evidence corroborating platelet-induced EMT, FMT and fibrogenesis in adenomyosis...
October 10, 2016: Reproductive Biology and Endocrinology: RB&E
Maria Francesca Perelló, Maria Ángeles Martínez-Zamora, Ximena Torres, Jordina Munrós, Juan Balasch Cortina, Francisco Carmona
BACKGROUND: The identification of presurgical clinical markers may be helpful to allow the staging of endometriosis severity. It has been suggested that pain characteristics orientate the gynecologist about the anatomical involvement of endometriosis. The study was performed to analyze the correlation between pain symptoms and the anatomical location of endometriosis. METHODS: One hundred fifty-five consecutive patients with a complete removal of deep infiltrating endometriosis (DIE) were included...
October 7, 2016: Gynecologic and Obstetric Investigation
Yong Li, Hui Qi, Wenqin Ma, Chaoying Wu, Xia Li, Danmei Zhao, Wenfeng Ye, Mei Xiang
STUDY OBJECTIVE: Our objective was to demonstrate the tips and tricks of a simpler technique for temporary blocking of the uterine artery in laparoscopic resection of the diffuse adenomyosis lesion to make the procedure more efficient and reproducible. DESIGN: This study is designed to be a step-by-step explanation of the technique using videos and pictures (Canadian Task Force Classification III). SETTING: This study was conducted at Changzhou Maternal and Child Health Hospital in Changzhou, China...
October 1, 2016: Journal of Minimally Invasive Gynecology
Somayyeh Safari, Azita Faramarzi, Azam Agha-Rahimi, Mohammad Ali Khalili
The aim was to report a healthy live birth using re-vitrified-warmed cleavage-stage embryos derived from supernumerary warmed embryos after frozen embryo transfer (ET) in a patient with recurrent implantation failure (RIF). The case was a 39-year-old female with a history of polycystic ovarian syndrome and adenomyosis, along with RIF. After ovarian hyperstimulation, 33 cumulus-oocyte complexes were retrieved and fertilized with conventional in vitro fertilization and intracytoplasmic sperm injection. Because of the risk of ovarian hyperstimulation syndrome, 16 grade B and C embryos were vitrified...
September 2016: Clinical and Experimental Reproductive Medicine
Chan Woo Park, Min Hye Choi, Kwang Moon Yang, In Ok Song
OBJECTIVE: To determine the preferred regimen for women with adenomyosis undergoing in vitro fertilization (IVF), we compared the IVF outcomes of fresh embryo transfer (ET) cycles with or without gonadotropin-releasing hormone (GnRH) agonist pretreatment and of frozen-thawed embryo transfer (FET) cycles following GnRH agonist treatment. METHODS: This retrospective study included 241 IVF cycles of women with adenomyosis from January 2006 to January 2012. Fresh ET cycles without (147 cycles, group A) or with (105 cycles, group B) GnRH agonist pretreatment, and FET cycles following GnRH agonist treatment (43 cycles, group C) were compared...
September 2016: Clinical and Experimental Reproductive Medicine
J Y Ma, H K Kim, S Y Kang, Y J Chung, H H Cho, J H Kim, M R Kim
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
S Wang, H Duan
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
A A Shklyar, L V Adamyan, E A Kogan, T Y Gavrilova, I F Kozachenko
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
N B Rindos, M Ross, G Carter, R Guido
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
J Zhang, W Shi
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
Isabelle Streuli, Pietro Santulli, Sandrine Chouzenoux, Charles Chapron, Frédéric Batteux
We investigated whether serum osteopontin (OPN) levels are different according to specific phenotypes of adenomyosis and endometriosis. We conducted a prospective laboratory study in a university referral center for endometriosis between May 2005 and May 2013 and included 148 nonpregnant women, younger than 42 years, undergoing surgery for a benign gynecological condition and who had a preoperative pelvic magnetic resonance imaging (MRI). The presence of focal and/or diffuse adenomyosis was determined by pelvic MRI, and women were classified into 3 groups: no-adenomyosis (No-AM), isolated diffuse adenomyosis (DIF-AM), and focal adenomyosis with or without diffuse adenomyosis (FOC-AM)...
September 27, 2016: Reproductive Sciences
L Li, J H Leng, J J Zhang, S Z Jia, X Y Li, J H Shi, Y Dai, J R Zhang, T Li, X X Xu, Z Z Liu, S S You, X Y Chang, J H Lang
Objective: To investigate the changes of mestruation patterns and adverse effects during the treatment of levonorgestrel-releasing intrauterine system(LNG-IUS)for symptomatic adenomyosis in a prospective cohort study. Methods: From December, 2006 to December, 2014, patients of symptomatic adenomyosis diagnosed by transvaginal ultrasound in Peking Union Medical College Hospital were given LNG-IUS. Before and after placement of IUS, all patients' parameters were recorded, including carrying status of IUS, symptoms and scores of dysmenorrhea, menstruation scores, biochemical indicators, physical parameters, menstruation patterns and adverse effects...
September 25, 2016: Zhonghua Fu Chan Ke za Zhi
Z F Huo, C L Chen, P Liu, B Ma, H Duan, B Y Jiang, Y X Tang, Y J Xu, J H Zhu
Objective: To investigate the related factors on effects of uterine artery embolization(UAE)in the treatment of dysmenorrhea in patients with adenomyosis, and to construct and validate the efficacy prediction model. Methods: A total of 127 cases of adenomyosis patients with symptoms of dysmenorrhea in Guangzhou No.1 People's Hospital and Nanfang Hospital of Southern Medical University from June 1999 to December 2009 were reviewed. The evaluation standard was to improve the degree of dysmenorrhea, the related factors of efficacy were analysed...
September 25, 2016: Zhonghua Fu Chan Ke za Zhi
M Z Ye, X L Deng, X G Zhu, M Xue
Objective: To investigate the clinical effect of dysmenorrhea in patients with adenomyosis treated by high intensity focused ultrasound(HIFU)ablation combined with gonadotropin-releasing hormone agonist(GnRH-a)and levonorgestrel-releasing intrauterine system(LNG-IUS). Methods: From April 2012 to December 2015, 477 cases of adenomyosis patients with dysmenorrhea were treated by HIFU in the Third Xiangya Hospital. Among them, some patients were treated with HIFU alone, some of them were treated with HIFU combined with GnRH-a and(or)LNG-IUS, thus were classified as H group, H+G group, H+M group and H+G+M group...
September 25, 2016: Zhonghua Fu Chan Ke za Zhi
J H Lang
No abstract text is available yet for this article.
September 25, 2016: Zhonghua Fu Chan Ke za Zhi
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