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Adenomyosis

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https://www.readbyqxmd.com/read/28807810/unique-learning-system-for-uterine-artery-embolization-for-symptomatic-myoma-and-adenomyosis-for-obstetrician-gynecologists-in-cooperation-with-interventional-radiologists-evaluation-of-uae-from-the-point-of-view-of-gynecologists-who-perform-uae
#1
Shu Soeda, Tsuyoshi Hiraiwa, Megumi Takata, Norihito Kamo, Hirofumi Sekino, Shinji Nomura, Manabu Kojima, Hyo Kyozuka, Takeharu Ozeki, Shiro Ishii, Tadanobu Tameda, Kimisato Asano, Makoto Miyazaki, Toshifumi Takahashi, Takafumi Watanabe, Yasunori Taki, Keiya Fujimori
STUDY OBJECTIVE: To evaluate a unique learning system for uterine artery embolization (UAE), and its feasibility and clinical outcomes for symptomatic uterine leiomyoma and adenomyosis performed by obstetrician- gynecologists in cooperation with interventional radiologists. DESIGN: Retrospective study (Canadian Task Force classification II-2). SETTING: University hospital. PATIENTS: 173 patients who underwent UAE for symptomatic myoma and adenomyosis...
August 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28807397/colorectal-endometriosis-associated-infertility-should-surgery-precede-art
#2
Sofiane Bendifallah, Horace Roman, Emmanuelle Mathieu d'Argent, Salma Touleimat, Jonathan Cohen, Emile Darai, Marcos Ballester
OBJECTIVE: To compare the impact of first-line assisted reproductive technology (ART; intracytoplasmic sperm injection [ICSI]-IVF) and first-line colorectal surgery followed by ART on fertility outcomes in women with colorectal endometriosis-associated infertility. DESIGN: Retrospective matched cohort study using propensity score (PS) matching (PSM) analysis. SETTING: University referral centers. PATIENT(S): A total of 110 women were analyzed from January 2005 to June 2014...
August 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28802706/the-impact-of-adenomyosis-on-the-outcome-of-ivf-embryo-transfer
#3
Dimitrios Mavrelos, Tom K Holland, Oliver O'Donovan, Mohamed Khalil, George Ploumpidis, Davor Jurkovic, Yakoub Khalaf
Our study examined the impact of adenomyosis on the chance of clinical pregnancy after IVF and embryo transfer (IVF-ET). This was a prospective multicentre study from April 2013 to October 2015. We included 375 women with history of infertility who attended for a 3D scan prior to IVF-ET. A total of 150/375 (40.0%, 95% confidence interval [CI] 35.2-45.0) women had clinical pregnancy. Women with any feature of adenomyosis had a lower clinical pregnancy rate (21/72 [29.2%, 95% CI 18.6-39.6] versus 129/303 [42...
July 29, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28791275/diagnostic-dilemma-in-cervical-endocervicosis
#4
Seung Hyun Lee, Jung-Woo Park, So Ra Oh, Seo Hee Rha
Müllerianosis is an embryonic Müllerian disease, resulting in the formation of the benign diseases adenomyosis, endometriosis, endosalpingiosis, and endocervicosis. Endocervicosis primarily affects the bladder, and rarely the cervix. Cervical endocervicosis, which is also a pseudoneoplastic glandular lesion, could be misinterpreted as a premalignant or even a malignant lesion. Because the treatment of these diseases is very different, early clinical diagnosis is important. Unfortunately, however, this lesion is difficult to diagnose preoperatively using clinical and radiological information, and pathological confirmation is needed...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28791273/significant-elevation-in-serum-ca-125-and-ca-19-9-levels-with-torsion-of-the-hydrosalpinx-in-a-postmenopausal-woman
#5
Ji Hye Kim, Hyo Jin Jung, Seung Hun Song
Isolated torsion of the fallopian tube in postmenopausal women is rare. In this case report, we detail the case of a 53-year-old patient who presented with adenomyosis and a left hydrosalpinx with high levels of CA 125 and CA 19-9. The isolated torsion of the left hydrosalpinx was observed during the operation. The serum levels of CA 125 and CA 19-9 were reduced from 129.62 and 348 to 58.2 and 12.41 U/mL, respectively, after total laparoscopic hysterectomy with salpingectomy. On radiologic evaluation, there were no other factors that may have influenced the increase in serum levels of CA 125 and CA 19-9 in this patient, which were reduced after operation...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28777463/role-of-3-dimensional-sonography-in-the-assessment-of-submucous-fibroids-a-pilot-study
#6
Alieke L Keizer, Lotte L Nieuwenhuis, Jos W R Twisk, Judith A F Huirne, Wouter J K Hehenkamp, Hans A M Brölmann
OBJECTIVES: To investigate the accuracy and reliability of 3-dimensional (3D) transvaginal sonography in classifying submucous fibroids using the International Federation of Gynecology and Obstetrics PALM-COEIN (polyp, adenomyosis, leiomyoma, malignancy and hyperplasia, coagulopathy, ovulatory dysfunction, endometrial, iatrogenic, and not yet classified) classification and protrusion (percent) compared to 2-dimensional (2D) transvaginal sonography, 2D saline infusion sonography, and 3D saline infusion sonography, using hysteroscopy as a reference test...
August 4, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28766365/concomitant-use-of-transvaginal-sonography-and-doppler-indices-improve-diagnosis-of-adenomyosis
#7
Duygu Kara Bozkurt, Murat Bozkurt, Ahmet Said Cil, Mert Ulaş Barut, Aynur Adeviye Ersahin, Eray Çalıskan
This study was planned to investigate whether measuring of Doppler indices with TV-DUS improved the diagnosis of adenomyosis. Preoperative Doppler indices of subjects with a preliminary diagnosis of adenomyosis were compared with the histopathological results of excised specimens. Sensitivity, specificity and positive/negative predictive values (PPV, NPV) of the measured indices were also calculated. Sensitivity, specificity, PPV and NPV and positive and negative likelihood ratios (LR+) and (LR-) of TV-US in the diagnosis of adenomyosis were found to be 70...
August 2, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28763746/rhein-ameliorates-adenomyosis-by-inhibiting-nf-%C3%AE%C2%BAb-and-%C3%AE-catenin-signaling-pathway
#8
Tingting Feng, Shaobin Wei, Yan Wang, Xianyun Fu, Ling Shi, Liyuan Qu, Xiaoxue Fan
In the present study, we examined the effects of rhein on pituitary gland implantation-induced adenomyosis, an animal model which mimics human adenomyosis. Oral administration of rhein dose-dependently attenuated hyperplastic and hypertrophic myometrium and improved adenomyosis. The activation of NF-κB and β-catenin signaling pathway was observed in the ectopic endometria. While, rhein dose dependently inhibited the expressions of p-p65, p-AKT and actived Rac1. As Rac1 activation controlled nuclear localization of β-catenin during canonical Wnt signaling, we found that the degradation complex of β-catenin was improved by rhein...
July 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28762845/decreased-expression-of-interleukin-37-in-the-ectopic-and-eutopic-endometria-of-patients-with-adenomyosis
#9
Jian Fa Jiang, Song Shu Xiao, Min Xue
Previous studies have shown that alterations of cytokines might play a role in the pathogenesis of adenomyosis. This study aims to investigate the expression of interleukin-37 (IL-37), an anti-inflammatory cytokine, in the eutopic and ectopic endometria of patients with adenomyosis. Endometrial specimens were collected from 30 women with adenomyosis and 20 without adenomyosis. The gene and protein expression of IL-37 was measured using a quantitative real-time polymerase chain reaction and immunohistochemistry, respectively...
August 1, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28751234/hysteroscopic-treatment-of-a-uterine-cystic-adenomyosis
#10
Wenchao Sun, Xiaoyan Guo, Linling Zhu, Xiaoyang Fei, Zhifen Zhang, Dingheng Li
No abstract text is available yet for this article.
July 24, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28741605/a-rare-case-of-intramural-m%C3%A3-llerian-adenosarcoma-arising-from-adenomyosis-of-the-uterus
#11
Sun-Jae Lee, Ji Y Park
Müllerian adenosarcomas usually arise as polypoid masses in the endometrium of post-menopausal women. Occasionally, these tumors arise in the cervix, vagina, broad and round ligaments, ovaries and rarely in extragenital sites; these cases are generally associated with endometriosis. We experienced a rare case of extraendometrial, intramural adenosarcoma arising in a patient with adenomyosis. A 40-year-old woman presented with sudden-onset suprapubic pain. The imaging findings suggested leiomyoma with cystic degeneration in the uterine fundus...
July 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28739414/conservative-surgery-for-adenomyosis-and-results-a-systematic-review
#12
REVIEW
Grace Younes, Togas Tulandi
The traditional treatment for women with symptomatic adenomyosis is hysterectomy. However, reproductive aged women should be managed with less invasive treatments including medical treatment. For patients who are refractory or unsuitable to long term medical treatment, or those with focal adenomyoma, conservative surgeries could be offered. The objective of our study was to review available conservative surgeries for the treatment of adenomyosis, their complications, and the rates of success and recurrence...
July 21, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28737239/long-term-use-of-dienogest-in-the-treatment-of-painful-symptoms-in-adenomyosis
#13
Yutaka Osuga, Manabu Watanabe, Atsushi Hagino
AIM: We aimed to investigate the safety and efficacy of dienogest (DNG), a progestational 19-norsteroid, administered for 52 weeks in patients with symptomatic adenomyosis. METHODS: A total of 130 patients with adenomyosis received 2 mg of DNG orally each day for 52 weeks. In cases of complicated anemia, patients were treated for anemia prior to receiving the medication. Adverse events and adverse drug reactions were evaluated. The patients' pain symptoms (dysmenorrhea and pelvic pain from adenomyosis) were assessed using a pain-scoring tool...
July 24, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28725636/epithelial-to-mesenchymal-transition-in-the-female-reproductive-tract-from-normal-functioning-to-disease-pathology
#14
REVIEW
Olena Bilyk, Mackenzie Coatham, Michael Jewer, Lynne-Marie Postovit
Epithelial-to-mesenchymal transition (EMT) is a physiological process that is vital throughout the human lifespan. In addition to contributing to the development of various tissues within the growing embryo, EMT is also responsible for wound healing and tissue regeneration later in adulthood. In this review, we highlight the importance of EMT in the development and normal functioning of the female reproductive organs (the ovaries and the uterus) and describe how dysregulation of EMT can lead to pathological conditions, such as endometriosis, adenomyosis, and carcinogenesis...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28721180/adenomyosis-back-to-the-future
#15
Z Ferraz, N Nogueira-Martins, F Nogueira-Martins
Adenomyosis is a benign invasion of endometrium into the myometrium. It produces a diffusely enlarged uterus and predominantly affects women in the late reproductive age. It has recently been associated with a negative impact on female fertility. Diagnosis is challenging because nonspecific symptoms can be present. However, it is asymptomatic in the majority of women. Medical treatment with GnRH agonist seems to be promising, particularly in subfertile women. A retrospective study was performed (182 patients) by examination of histopathological results with "adenomyosis" between January/2013 and September/2016...
March 2017: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28693952/pathogenesis-of-adenomyosis-an-update-on-molecular-mechanisms
#16
REVIEW
Silvia Vannuccini, Claudia Tosti, Francisco Carmona, S Joseph Huang, Charles Chapron, Sun-Wei Guo, Felice Petraglia
Adenomyosis is a uterine disorder becoming more commonly diagnosed in women of reproductive age because of diagnostic imaging advancements. The new epidemiological scenario and the clinical evidence of pelvic pain, abnormal uterine bleeding and infertility are changing the classic perspective of adenomyosis as a premenopausal disease. In the last decade, the evaluation of multiple molecular mediators has improved our knowledge of pathogenic mechanisms of adenomyosis, supporting that this is an independent disease from endometriosis...
June 27, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28683602/postoperative-levonorgestrel-releasing-intrauterine-system-insertion-after-gonadotropin-releasing-hormone-agonist-treatment-for-preventing-endometriotic-cyst-recurrence-a-prospective-observational-study
#17
Min Kyoung Kim, Seung Joo Chon, Jae Hoon Lee, Bo Hyon Yun, SiHyun Cho, Young Sik Choi, Byung Seok Lee, Seok Kyo Seo
OBJECTIVE: The aim of this study was to evaluate the effectiveness of postoperative levonorgestrel-releasing intrauterine system (LNG-IUS) insertion after gonadotropin-releasing hormone agonist (GnRH-a) treatment for preventing endometriotic cyst recurrence. STUDY DESIGN: The LNG-IUS was applied to 28 women who had undergone surgery for endometriosis followed by 6 cycles of GnRH-a treatment. Clinical characteristics, endometriosis recurrence, and adverse effects were analyzed...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28668161/benign-gynecologic-conditions-of-the-uterus
#18
REVIEW
Zahra Kassam, Iva Petkovska, Carolyn L Wang, Angela M Trinh, Aya Kamaya
In this article, the authors review the anatomy, pathophysiology, MR imaging features, and diagnostic criteria for benign uterine conditions, including adenomyosis, uterine leiomyomas, retained products of conception, and uterine arteriovenous malformations. Pearls, pitfalls, and variants are discussed for each entity as well as important imaging features that can affect management decisions.
August 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28665807/new-paradigms-in-the-conservative-surgical-and-interventional-management-of-adenomyosis
#19
Farah A Alvi, Laura M Glaser, Angela Chaudhari, Susan Tsai, Magdy P Milad
PURPOSE OF REVIEW: Adenomyosis is commonly diagnosed in women of reproductive age. Interest in conservative interventions has grown as more women desire fertility preservation or avoidance of hysterectomy. This review discusses surgical and interventional methods for treatment of symptomatic adenomyosis. The technique, evidence, and utility of each method are described. RECENT FINDINGS: Hysteroscopic ablative techniques are associated with lower morbidity than with hysterectomy but may result in an unacceptable risk of treatment failure...
August 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28642638/laparoscopic-surgery-for-focal-adenomyosis
#20
Jae-Young Kwack, Yong-Soon Kwon
BACKGROUND AND OBJECTIVES: For conservative surgical treatment of focal uterine adenomyosis, laparoscopic adenomyomectomy has been increasingly performed, so that reassessment to determine the safety and efficacy of the laparoscopic surgical technique in a larger number of cases and reevaluation for reproducibility for laparoscopic adenomyomectomy is needed. We evaluate the clinical outcomes of laparoscopic adenomyomectomy with transient occlusion of uterine arteries (TOUA) for focal uterine adenomyosis performed by a single surgeon at a single institute...
April 2017: JSLS: Journal of the Society of Laparoendoscopic Surgeons
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