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Adenomyosis

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https://www.readbyqxmd.com/read/28106642/imaging-in-endometriosis-and-adenomyosis
#1
Luis R Hoyos, Beryl Benacerraf, Elizabeth E Puscheck
Endometriosis and adenomyosis may be accurately diagnosed using ultrasound (US). Several findings are characteristic and various US modalities have been described. Recent development of 3-dimensional transvaginal US has resulted in a major advance in the evaluation of adenomyosis. Endometriotic manifestations can also be accurately evaluated with US, which is and should remain the first-line approach for the evaluation of these conditions. Obvious advantages over magnetic resonance imaging include its wide-availability, tolerability, less time-consumption, more accessible price and familiarity of gynecologists with its use...
March 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28093048/myofibroblasts-are-evidence-of-chronic-tissue-microtrauma-at-the-endometrial-myometrial-junctional-zone-in-uteri-with-adenomyosis
#2
Mohamed Gamal Ibrahim, Martin Sillem, Johanna Plendl, Vito Chiantera, Jalid Sehouli, Sylvia Mechsner
BACKGROUND: Adenomyosis (AM) uteri exhibit hyperperistalsis. The latter causes a chronic tissue trauma at the endometrial-myometrial junctional zone (EMJZ). Upon tissue trauma, microdehiscences in the myometrium facilitate the translocation of basal endometrial fragments into the myometrium. There, a metaplasia (mediated by transforming growth factor β1 [TGFβ1] and connective tissue growth factor [CTGF]) occurs and AM lesions develop. The abundance of myofibroblasts in a tissue hallmarks metaplasia and points to a tissue microtrauma...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28080921/uterine-adenomyosis-and-an-endometrial-polyp-in-a-rock-hyrax-procavia-capensis
#3
Holly J Holman, Katherine Gailbreath
An 8-yr-old nulliparous, female rock hyrax ( Procavia capensis ) had intermittent mucoid to bloody discharge late winter-early spring for two consecutive years. Fragments of necrotic tissue, suspected to be vaginal or rectal in origin, were passed on two occasions. Physical examination, radiographs, and ultrasound did not identify the source of the tissue. Exploratory laparotomy and ovariohysterectomy were performed. On histopathology, a diagnosis of adenomyosis with a uterine polyp was made. Postsurgical complications included incisional infection and renal compromise that were medically managed and resolved...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28076877/ultrasound-imaging-for-ovarian-and-deep-infiltrating-endometriosis
#4
Caterina Exacoustos, Errico Zupi, Emilio Piccione
The main challenges of imaging for endometriosis are the detection of nonovarian disease and the evaluation of the extension of the disease into pelvic structures. Transvaginal ultrasonography (TVS) has been proposed as the first-line imaging technique because it allows extensive exploration of the pelvis. The "typical" endometrioma is a unilocular cyst with homogeneous low-level echogenicity (ground glass echogenicity) of the cyst fluid. The use of color Doppler helps avoid classifying malignancies as endometriomas, defining the presence of vascular flow in papillations...
January 11, 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28069193/safety-of-ultrasound-guided-high-intensity-focused-ultrasound-ablation-for-diffuse-adenomyosis-a-retrospective-cohort-study
#5
Yujie Feng, Liang Hu, Wenzhi Chen, Rong Zhang, Xi Wang, Jinyun Chen
OBJECTIVES: To evaluate the safety of ultrasound-guided high-intensity focused ultrasound (HIFU) ablation for patients with diffuse adenomyosis. METHODS: This was a retrospective cohort study. The data was collected from 417 symptomatic adenomyosis patients who underwent ultrasound-guided HIFU between January 2012 and December 2015 at 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China. Among them were 260 patients with diffuse adenomyosis (Group D) and 157 patients with focal adenomyosis (Group F)...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28057126/-value-of-using-gonadotropin-releasing-hormone-agonist-pretreatment-in-adenomyosis-patients-before-adenomyomectomy
#6
A L Tan, R Y Luo, M Gong
Objective: To investigate the value of using gonadotropin-releasing hormone agonist (GnRH-a) pretreatment in adenomyosis patients before adenomyomectomy. Methods: From May 2012 to September 2015, 87 patients with adenomyosis who were non-effective to conservative therapy in Renmin Hospital of Wuhan University were enrolled in this study. According to the principle of randomized control, 41 patients were in the treatment group who were treated with GnRH-a 2-3 cycles before adenomyomectomy, while 46 patients in the control group...
December 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28005589/transvaginal-ultrasound-for-the-diagnosis-of-abnormal-uterine-bleeding
#7
Karen C Wheeler, Steven R Goldstein
Transvaginal ultrasound is the first-line imaging test for the evaluation of abnormal uterine bleeding in both premenopausal and postmenopausal women. Transvaginal ultrasound can be used to diagnose structural causes of abnormal bleeding such as polyps, adenomyosis, leiomyomas, hyperplasia, and malignancy, and can also be beneficial in making the diagnosis of ovulatory dysfunction. Traditional 2-dimensional imaging is often enhanced by the addition of 3-dimension imaging with coronal reconstruction and saline infusion sonohysterography...
December 21, 2016: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28002623/comprehensive-screening-for-med12-mutations-in-gynecological-mesenchymal-tumors-identified-morphologically-distinctive-mixed-epithelial-and-stromal-tumors
#8
Chang-Tsu Yuan, Wen-Chih Huang, Cheng-Han Lee, Ming-Chieh Lin, Chen-Hui Lee, Yu-Chien Kao, Hsuan-Ying Huang, Kuan-Ting Kuo, Jen-Chieh Lee
BACKGROUND: MED12 exon 2 mutations have been identified in most uterine leiomyomas and mammary fibroepithelial tumors. MED12 has not been genotyped in most other gynecological mesenchymal tumors. DESIGN: 68 uncommon gynecological mesenchymal tumors were genotyped for MED12 exon 2, including 27 müllerian adenosarcomas (including 3 tentatively diagnosed as "variant adenosarcomas"), 6 cellular angiofibromas, 6 aggressive angiomyxomas, 5 angiomyofibroblastomas, 5 superficial myofibroblastomas, 5 atypical polypoid adenomyomas, and 14 endometrial stromal sarcomas...
December 21, 2016: Histopathology
https://www.readbyqxmd.com/read/27986572/downregulation-of-dna-methyltransferase-3-alpha-promotes-cell-proliferation-and-invasion-of-ectopic-endometrial-stromal-cells-in-adenomyosis
#9
Yang Zou, Fa-Ying Liu, Li-Qun Wang, Jiu-Bai Guo, Bi-Cheng Yang, Xi-Di Wan, Feng Wang, Ming He, Ou-Ping Huang
Adenomyosis is a common benign gynecological condition in female reproductive tract and the detailed molecular etiology remains largely elusive. Previous studies implicated that deregulated expression of DNA (cytosine-5)-methyltransferase 3A (DNMT3A), a de novo DNA methyltransferase, might be involved in the pathogenesis of adenomyosis. Meanwhile, ectopic endometrial stromal cells (EESCs) were suggested to play crucial roles in adenomyosis. Herein, we evaluated the expression of DNMT3A protein in 36 ectopic endometriums with adenomyosis and 37 eutopic endometriums in controls with Western blotting (WB) or immunohistochemistry (IHC), we found that the expression of DNMT3A was significantly decreased in the ectopic endometriums and EESCs in adenomyosis relative to that of eutopic endometriums and EESCs in control samples, respectively...
March 10, 2017: Gene
https://www.readbyqxmd.com/read/27974911/the-etiopathogenesis-of-uterine-fibromatosis
#10
EDITORIAL
L Manta, N Suciu, O Toader, R M Purcărea, A Constantin, F Popa
Uterine fibroids or uterine leiomyomas are the most common benign tumors of the uterus among women of fertile age, while the etiology is still incompletely elucidated. The occurrence and development of the fibromatosis may be related to certain risk factors and genic mechanisms, although the exact causes are not yet fully known. The development of uterine fibroids is correlated not only with the metabolism and with the level of female sexual hormones, estrogen, and progesterone, but also with the number of these hormone receptors expressed on the surface of the myometrium...
January 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27940396/immunohistochemical-expression-pattern-of-metastasis-suppressor-kiss-1-protein-in-adenomyosis-lesions-and-normal-endometrium
#11
I Kolioulis, M Zafrakas, G Grimbizis, D Miliaras, A Timologou, J N Bontis, B C Tarlatzis
OBJECTIVE: Kisspeptins are multifunctional peptides; it has been shown that they act as inhibitors of tumor metastasis in a range of cancers and that they are also involved in cell invasion through regulation of matrix metalloproteinases (MMPs). The aim of this study was to investigate the expression of KISS-1 protein in adenomyosis lesions compared with matched eutopic endometrium, as well as with endometrium from patients without adenomyosis. STUDY DESIGN: In this comparative, non-interventional study, adenomyosis and corresponding eutopic endometrium samples from women with histologically proven adenomyosis after hysterectomy, and eutopic endometrium samples from women without adenomyosis were analysed...
December 5, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27924072/p53-and-murine-double-mimute-2-mdm2-expression-changes-and-significance-in-different-types-of-endometrial-lesions
#12
Zhongyong Jiang, Wanqing Xu, Gang Dan, Yuan Liu, Jie Xiong
BACKGROUND Endometrial lesions are common in obstetrics and gynecology, including endometrial polyps, uterine adenomyosis, and malignant endometrial adenocarcinoma. Endometrial lesions seriously affect women's health, fertility, quality of life, and life safety. As a pro-apoptosis gene, p53 is considered to be closely related with human tumors. Murine double mimute 2 (MDM2) is an oncogene that can promote tumor occurrence and development. P53 and MDM2 expression and significance in different types of endometrial lesions have not been fully elucidated...
December 7, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27916069/-pregnancy-outcomes-and-symptom-improvement-of-patients-with-adenomyosis-treated-with-high-intensity-focused-ultrasound-ablation
#13
C Y Zhou, X J Xu, J He
Objective: To investigate the symptom improvement and pregnancy outcomes of patients with adenomyosis after treatment with high intensity focused ultrasound (HIFU) ablation. Methods: From October 2010 to October 2015, 68 patients with adenomyosis who wish to get pregnancies were treated with HIFU ablation in Suining Central Hospital. Among these patients, 56 presented with dysmenorrhea, 11 presented with menorrhagia, and 1 patient complained both; 41 of them had histories of abnormal pregnancy. The clinical data were analyzed retrospectively...
November 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27903796/decreased-endometrial-expression-of-leukemia-inhibitory-factor-receptor-disrupts-the-stat3-signaling-in-adenomyosis-during-the-implantation-window
#14
Chih-Feng Yen, Shuen-Kuei Liao, S Joseph Huang, Selcuk Tabak, Felice Arcuri, Chyi-Long Lee, Aydin Arici, Felice Petraglia, Hsin-Shih Wang, Umit A Kayisli
BACKGROUND: Adenomyosis was found to have negative impacts on embryo implantation. Leukemia inhibitory factor (LIF), proposed to be a molecular marker for endometrial receptivity, works through the LIF receptor (LIFR) on both the embryo and the endometrium. We aimed to evaluate the endometrial expression of LIF and LIFR and its subsequent signaling in patients with adenomyosis during the window of implantation (WOI). METHODS: Endometrium was obtained during the WOI from patients with adenomyosis (age <45 years) who underwent hysterectomy and from age-matched controls who had no endometriosis or adenomyosis...
January 1, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27865118/dienogest-reduces-proliferation-ngf-expression-and-nerve-fiber-density-in-human-adenomyosis
#15
Arisa Takeuchi, Kaori Koga, Mariko Miyashita, Tomoko Makabe, Fusako Sue, Miyuki Harada, Tetsuya Hirata, Yasushi Hirota, Tomoyuki Fujii, Yutaka Osuga
OBJECTIVES: To evaluate the in vivo effect of dienogest on proliferation, apoptosis, aromatase expression, vascular density, nerve growth factor (NGF) expression and nerve fiber density in human adenomyosis tissue. STUDY DESIGN: Twelve women who underwent hysterectomy for adenomyosis were enrolled. Six patients received dienogest treatment prior to hysterectomy (dienogest group), and age-matched six patients who had not received any hormonal treatment for ≥3 months before surgery (control group)...
December 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27856389/mini-laparoscopy-of-removal-partial-adnexae-at-the-time-of-hysterectomy
#16
António Gutierrez Setúbal, João Sequeira Alves, Olga Lavado, Joana Faria
STUDY OBJECTIVE: To describe our technique of mini laparoscopic adnexectomy or salpingectomy at the time of total laparoscopic hysterectomy DESIGN: Step-by-step video explanation of our technique SETTING: The advantages of laparoscopic surgery have been widely recognised in the past two decades: improved vision, exposure, reduction in operative trauma because of smaller incisions and more gentle tissue´s handling, that result in a faster postoperative recovery. The technology development has allowed the use of smaller caliber instruments while maintaining the high standard surgical performance...
November 14, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27847535/value-of-ultrasound-shear-wave-elastography-in-the-diagnosis-of-adenomyosis
#17
S Acar, E Millar, M Mitkova, V Mitkov
BACKGROUND: The aim of the study was to assess the accuracy of ultrasound shear wave elastography in the diagnosis of adenomyosis. METHODS: One hundred and fifty three patients were examined. Ninety-seven patients were with suspected adenomyosis and 56 patients were with unremarkable myometrium. Adenomyosis was confirmed in 39 cases (A subgroup) and excluded in 14 cases (B subgroup) in the main group based on morphological examination. All patients underwent ultrasound examination using an Aixplorer (Supersonic Imagine, France) scanner with application of shear wave elastography during transvaginal scanning...
November 2016: Ultrasound: Journal of the British Medical Ultrasound Society
https://www.readbyqxmd.com/read/27843659/rare-case-of-leiomyoma-and-adenomyosis-in-mayer-rokitansky-kuster-hauser-syndrome
#18
P S Hoo, A R Norhaslinda, J N Shah Reza
We report a case of adenomyosis which developed from a hypoplastic uterus and leiomyoma in a patient with MRKH syndrome. A 45-year-old Malay female with primary amenorrhoea and primary infertility presented with abdominal mass and abdominal pain. She is phenotypically female, has well developed secondary sexual characteristics, and has normal female external genitalia with shallow vagina dimple. Transabdominal ultrasonography showed a homogenous adnexal mass of 10 × 8 cm, uterus sized 5 × 4 cm, and normal kidneys...
2016: Case Reports in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27818130/structured-imaging-technique-in-the-gynecologic-office-for-the-diagnosis-of-abnormal-uterine-bleeding
#19
REVIEW
Margit Dueholm, Ina Marie D Hjorth
: The aim in the diagnosis of abnormal uterine bleeding (AUB) is to identify the bleeding cause, which can be classified by the PALM-COEIN (Polyp, Adenomyosis, Leiomyoma, Malignancy (and hyperplasia), Coagulopathy, Ovulatory disorders, Endometrial, Iatrogenic and Not otherwise classified) classification system. In a gynecologic setting, the first step is most often to identify structural abnormalities (PALM causes). Common diagnostic options for the identification of the PALM include ultrasonography, endometrial sampling, and hysteroscopy...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27810281/adenomyosis-and-abnormal-uterine-bleeding-aub-a-pathogenesis-diagnosis-and-management
#20
REVIEW
Jason A Abbott
The complex pathogenesis and variable presentation of adenomyosis make it one of the most difficult of the FIGO PALM-COIEN abnormal uterine bleeding group to diagnose and treat. Basic clinical parameters such as prevalence are difficult to accurately assess because histological confirmation is usually employed; however, because of the access to and accuracy and utilization of transvaginal ultrasound and other advanced imaging techniques such as MRI, noninvasive diagnosis is recognized to be highly accurate...
September 30, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
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