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Adenomyosis

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https://www.readbyqxmd.com/read/28197875/mri-us-or-real-time-virtual-sonography-in-the-evaluation-of-adenomyosis
#1
Valeria Vinci, Matteo Saldari, Maria Eleonora Sergi, Silvia Bernardo, Giuseppe Rizzo, Maria Grazia Porpora, Carlo Catalano, Lucia Manganaro
PURPOSE: Real-time virtual sonography (RVS) allows displaying and synchronizing real-time US and multiplanar reconstruction of MRI images. The purpose of this study was to evaluate the feasibility and ability of RVS to assess adenomyosis since literature shows US itself has a reduced diagnostic accuracy compared to MRI. MATERIALS AND METHODS: This study was conducted over a 4-month period (March-June 2015). We enrolled in the study 52 women with clinical symptoms of dysmenorrhea, methrorragia and infertility...
February 15, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28183227/molecular-characteristics-of-the-endometrium-in-uterine-adenomyosis-and-its-biochemical-microenvironment
#2
Chih-Feng Yen, S Joseph Huang, Chyi-Long Lee, Hsin-Shih Wang, Shuen-Kuei Liao
Adenomyosis, which manifests with focally or diffusely scattered endometrial tissue within the uterine myometrium, is an endometriosis-like disease with controversial pathogenesis and compromised reproductive outcomes. This review, including the in vitro and in vivo studies performed on human or mouse models, is aimed to summarize the specific molecular characteristics of endometrium in the biochemical microenvironments of uterine adenomyosis. Many studies attributed the endometrium as the main cause of pathogenesis, with evidence of differential genetic expression and/or epigenetic modulation as well as estrogen-induced epithelial-mesenchymal transition...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28150406/preoperative-assessment-of-factors-associated-with-difficulty-in-performing-total-laparoscopic-hysterectomy
#3
Ako Saito, Tetsuya Hirata, Kaori Koga, Masashi Takamura, Shinya Fukuda, Kazuaki Neriishi, Gia Pastorfide, Miyuki Harada, Yasushi Hirota, Osamu Wada-Hiraike, Tomoyuki Fujii, Yutaka Osuga
AIM: Our objective was to determine the preoperative factors associated with difficulty in total laparoscopic hysterectomy (TLH). METHODS: This retrospective clinical study included 157 patients who underwent TLH for leiomyoma or adenomyosis between 2009 and 2013. All patients underwent magnetic resonance imaging (MRI) before surgery. We categorized patients as 'difficult' if the operation time was > 243 min, if total blood loss was > 500 mL, or if conversion to laparotomy was necessary...
February 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28145109/current-status-of-high-intensity-focused-ultrasound-for-the-management-of-uterine-adenomyosis
#4
Vincent Y T Cheung
While high-intensity focused ultrasound has been used for some time in the management of uterine fibroids, its effectiveness and safety in managing adenomyosis is less well established. A literature review was performed of all eligible reports using this modality as a treatment for adenomyosis. Relevant publications were obtained from the PubMed electronic database from inception through March 2016. Eleven articles, including information from 1,150 treatments and follow-up data from 990 patients, were reviewed...
November 30, 2016: Ultrasonography
https://www.readbyqxmd.com/read/28118773/percutaneous-microwave-ablation-with-artificial-ascites-for-symptomatic-uterine-adenomyosis-initial-experience
#5
Ning Hai, Jing Zhang, Ruifang Xu, Zhi-Yu Han, FangYi Liu
PURPOSE: To evaluate the feasibility, safety and technical efficacy of ultrasound-guided percutaneous microwave ablation with artificial ascites for adenomyosis. MATERIALS AND METHODS: Between May 2015 and May 2016, a total of 25 patients with symptomatic adenomyosis who underwent ultrasound-guided percutaneous microwave ablation with artificial ascites were included in this retrospective study. A matching cohort of 50 patients underwent ultrasound-guided percutaneous microwave ablation without artificial ascites as controls...
January 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28110584/adenomyosis-and-adverse-perinatal-outcomes-increased-risk-of-second-trimester-miscarriage-preeclampsia-and-placental-malposition
#6
Ayako Hashimoto, Takayuki Iriyama, Seisuke Sayama, Toshio Nakayama, Atsushi Komatsu, Akito Miyauchi, Osamu Nishii, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
OBJECTIVE: To evaluate the potential impact of adenomyosis on the pregnancy outcomes by retrospectively investigating adenomyosis-complicated pregnancy cases. METHODS: We performed a retrospective case-control study. Forty-nine singleton pregnancy cases complicated with adenomyosis were included in this study. The controls (n = 245) were singleton pregnant women without adenomyosis and were frequency matched to adenomyosis cases by age, parity, and the need for assisted reproductive technology for this conception...
January 23, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28106642/imaging-in-endometriosis-and-adenomyosis
#7
Luis R Hoyos, Beryl Benacerraf, Elizabeth E Puscheck
Endometriosis and adenomyosis may be accurately diagnosed using ultrasound (US). Several findings are characteristic and various US modalities have been described. Recent development of 3-dimensional transvaginal US has resulted in a major advance in the evaluation of adenomyosis. Endometriotic manifestations can also be accurately evaluated with US, which is and should remain the first-line approach for the evaluation of these conditions. Obvious advantages over magnetic resonance imaging include its wide-availability, tolerability, less time-consumption, more accessible price and familiarity of gynecologists with its use...
March 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28093048/myofibroblasts-are-evidence-of-chronic-tissue-microtrauma-at-the-endometrial-myometrial-junctional-zone-in-uteri-with-adenomyosis
#8
Mohamed Gamal Ibrahim, Martin Sillem, Johanna Plendl, Vito Chiantera, Jalid Sehouli, Sylvia Mechsner
BACKGROUND: Adenomyosis (AM) uteri exhibit hyperperistalsis. The latter causes a chronic tissue trauma at the endometrial-myometrial junctional zone (EMJZ). Upon tissue trauma, microdehiscences in the myometrium facilitate the translocation of basal endometrial fragments into the myometrium. There, a metaplasia (mediated by transforming growth factor β1 [TGFβ1] and connective tissue growth factor [CTGF]) occurs and AM lesions develop. The abundance of myofibroblasts in a tissue hallmarks metaplasia and points to a tissue microtrauma...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28080921/uterine-adenomyosis-and-an-endometrial-polyp-in-a-rock-hyrax-procavia-capensis
#9
Holly J Holman, Katherine Gailbreath
An 8-yr-old nulliparous, female rock hyrax ( Procavia capensis ) had intermittent mucoid to bloody discharge late winter-early spring for two consecutive years. Fragments of necrotic tissue, suspected to be vaginal or rectal in origin, were passed on two occasions. Physical examination, radiographs, and ultrasound did not identify the source of the tissue. Exploratory laparotomy and ovariohysterectomy were performed. On histopathology, a diagnosis of adenomyosis with a uterine polyp was made. Postsurgical complications included incisional infection and renal compromise that were medically managed and resolved...
December 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28076877/ultrasound-imaging-for-ovarian-and-deep-infiltrating-endometriosis
#10
Caterina Exacoustos, Errico Zupi, Emilio Piccione
The main challenges of imaging for endometriosis are the detection of nonovarian disease and the evaluation of the extension of the disease into pelvic structures. Transvaginal ultrasonography (TVS) has been proposed as the first-line imaging technique because it allows extensive exploration of the pelvis. The "typical" endometrioma is a unilocular cyst with homogeneous low-level echogenicity (ground glass echogenicity) of the cyst fluid. The use of color Doppler helps avoid classifying malignancies as endometriomas, defining the presence of vascular flow in papillations...
January 2017: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/28069193/safety-of-ultrasound-guided-high-intensity-focused-ultrasound-ablation-for-diffuse-adenomyosis-a-retrospective-cohort-study
#11
Yujie Feng, Liang Hu, Wenzhi Chen, Rong Zhang, Xi Wang, Jinyun Chen
OBJECTIVES: To evaluate the safety of ultrasound-guided high-intensity focused ultrasound (HIFU) ablation for patients with diffuse adenomyosis. METHODS: This was a retrospective cohort study. The data was collected from 417 symptomatic adenomyosis patients who underwent ultrasound-guided HIFU between January 2012 and December 2015 at 1st Affiliated Hospital of Chongqing Medical University, Chongqing, China. Among them were 260 patients with diffuse adenomyosis (Group D) and 157 patients with focal adenomyosis (Group F)...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28057126/-value-of-using-gonadotropin-releasing-hormone-agonist-pretreatment-in-adenomyosis-patients-before-adenomyomectomy
#12
A L Tan, R Y Luo, M Gong
Objective: To investigate the value of using gonadotropin-releasing hormone agonist (GnRH-a) pretreatment in adenomyosis patients before adenomyomectomy. Methods: From May 2012 to September 2015, 87 patients with adenomyosis who were non-effective to conservative therapy in Renmin Hospital of Wuhan University were enrolled in this study. According to the principle of randomized control, 41 patients were in the treatment group who were treated with GnRH-a 2-3 cycles before adenomyomectomy, while 46 patients in the control group...
December 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28005589/transvaginal-ultrasound-for-the-diagnosis-of-abnormal-uterine-bleeding
#13
Karen C Wheeler, Steven R Goldstein
Transvaginal ultrasound is the first-line imaging test for the evaluation of abnormal uterine bleeding in both premenopausal and postmenopausal women. Transvaginal ultrasound can be used to diagnose structural causes of abnormal bleeding such as polyps, adenomyosis, leiomyomas, hyperplasia, and malignancy, and can also be beneficial in making the diagnosis of ovulatory dysfunction. Traditional 2-dimensional imaging is often enhanced by the addition of 3-dimension imaging with coronal reconstruction and saline infusion sonohysterography...
March 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28002623/comprehensive-screening-for-med12-mutations-in-gynecological-mesenchymal-tumors-identified-morphologically-distinctive-mixed-epithelial-and-stromal-tumors
#14
Chang-Tsu Yuan, Wen-Chih Huang, Cheng-Han Lee, Ming-Chieh Lin, Chen-Hui Lee, Yu-Chien Kao, Hsuan-Ying Huang, Kuan-Ting Kuo, Jen-Chieh Lee
BACKGROUND: MED12 exon 2 mutations have been identified in most uterine leiomyomas and mammary fibroepithelial tumors. MED12 has not been genotyped in most other gynecological mesenchymal tumors. DESIGN: 68 uncommon gynecological mesenchymal tumors were genotyped for MED12 exon 2, including 27 müllerian adenosarcomas (including 3 tentatively diagnosed as "variant adenosarcomas"), 6 cellular angiofibromas, 6 aggressive angiomyxomas, 5 angiomyofibroblastomas, 5 superficial myofibroblastomas, 5 atypical polypoid adenomyomas, and 14 endometrial stromal sarcomas...
December 21, 2016: Histopathology
https://www.readbyqxmd.com/read/27986572/downregulation-of-dna-methyltransferase-3-alpha-promotes-cell-proliferation-and-invasion-of-ectopic-endometrial-stromal-cells-in-adenomyosis
#15
Yang Zou, Fa-Ying Liu, Li-Qun Wang, Jiu-Bai Guo, Bi-Cheng Yang, Xi-Di Wan, Feng Wang, Ming He, Ou-Ping Huang
Adenomyosis is a common benign gynecological condition in female reproductive tract and the detailed molecular etiology remains largely elusive. Previous studies implicated that deregulated expression of DNA (cytosine-5)-methyltransferase 3A (DNMT3A), a de novo DNA methyltransferase, might be involved in the pathogenesis of adenomyosis. Meanwhile, ectopic endometrial stromal cells (EESCs) were suggested to play crucial roles in adenomyosis. Herein, we evaluated the expression of DNMT3A protein in 36 ectopic endometriums with adenomyosis and 37 eutopic endometriums in controls with Western blotting (WB) or immunohistochemistry (IHC), we found that the expression of DNMT3A was significantly decreased in the ectopic endometriums and EESCs in adenomyosis relative to that of eutopic endometriums and EESCs in control samples, respectively...
March 10, 2017: Gene
https://www.readbyqxmd.com/read/27974911/the-etiopathogenesis-of-uterine-fibromatosis
#16
EDITORIAL
L Manta, N Suciu, O Toader, R M Purcărea, A Constantin, F Popa
Uterine fibroids or uterine leiomyomas are the most common benign tumors of the uterus among women of fertile age, while the etiology is still incompletely elucidated. The occurrence and development of the fibromatosis may be related to certain risk factors and genic mechanisms, although the exact causes are not yet fully known. The development of uterine fibroids is correlated not only with the metabolism and with the level of female sexual hormones, estrogen, and progesterone, but also with the number of these hormone receptors expressed on the surface of the myometrium...
January 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27940396/immunohistochemical-expression-pattern-of-metastasis-suppressor-kiss-1-protein-in-adenomyosis-lesions-and-normal-endometrium
#17
I Kolioulis, M Zafrakas, G Grimbizis, D Miliaras, A Timologou, J N Bontis, B C Tarlatzis
OBJECTIVE: Kisspeptins are multifunctional peptides; it has been shown that they act as inhibitors of tumor metastasis in a range of cancers and that they are also involved in cell invasion through regulation of matrix metalloproteinases (MMPs). The aim of this study was to investigate the expression of KISS-1 protein in adenomyosis lesions compared with matched eutopic endometrium, as well as with endometrium from patients without adenomyosis. STUDY DESIGN: In this comparative, non-interventional study, adenomyosis and corresponding eutopic endometrium samples from women with histologically proven adenomyosis after hysterectomy, and eutopic endometrium samples from women without adenomyosis were analysed...
December 5, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27924072/p53-and-murine-double-mimute-2-mdm2-expression-changes-and-significance-in-different-types-of-endometrial-lesions
#18
Zhongyong Jiang, Wanqing Xu, Gang Dan, Yuan Liu, Jie Xiong
BACKGROUND Endometrial lesions are common in obstetrics and gynecology, including endometrial polyps, uterine adenomyosis, and malignant endometrial adenocarcinoma. Endometrial lesions seriously affect women's health, fertility, quality of life, and life safety. As a pro-apoptosis gene, p53 is considered to be closely related with human tumors. Murine double mimute 2 (MDM2) is an oncogene that can promote tumor occurrence and development. P53 and MDM2 expression and significance in different types of endometrial lesions have not been fully elucidated...
December 7, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27916069/-pregnancy-outcomes-and-symptom-improvement-of-patients-with-adenomyosis-treated-with-high-intensity-focused-ultrasound-ablation
#19
C Y Zhou, X J Xu, J He
Objective: To investigate the symptom improvement and pregnancy outcomes of patients with adenomyosis after treatment with high intensity focused ultrasound (HIFU) ablation. Methods: From October 2010 to October 2015, 68 patients with adenomyosis who wish to get pregnancies were treated with HIFU ablation in Suining Central Hospital. Among these patients, 56 presented with dysmenorrhea, 11 presented with menorrhagia, and 1 patient complained both; 41 of them had histories of abnormal pregnancy. The clinical data were analyzed retrospectively...
November 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27903796/decreased-endometrial-expression-of-leukemia-inhibitory-factor-receptor-disrupts-the-stat3-signaling-in-adenomyosis-during-the-implantation-window
#20
Chih-Feng Yen, Shuen-Kuei Liao, S Joseph Huang, Selcuk Tabak, Felice Arcuri, Chyi-Long Lee, Aydin Arici, Felice Petraglia, Hsin-Shih Wang, Umit A Kayisli
BACKGROUND: Adenomyosis was found to have negative impacts on embryo implantation. Leukemia inhibitory factor (LIF), proposed to be a molecular marker for endometrial receptivity, works through the LIF receptor (LIFR) on both the embryo and the endometrium. We aimed to evaluate the endometrial expression of LIF and LIFR and its subsequent signaling in patients with adenomyosis during the window of implantation (WOI). METHODS: Endometrium was obtained during the WOI from patients with adenomyosis (age <45 years) who underwent hysterectomy and from age-matched controls who had no endometriosis or adenomyosis...
January 1, 2016: Reproductive Sciences
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