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https://www.readbyqxmd.com/read/29139552/critical-evaluation-of-the-palm-coein-classification-system-among-women-with-abnormal-uterine-bleeding-in-low-resource-settings
#1
Divya Shubham, Anjali S Kawthalkar
OBJECTIVE: To assess the feasibility of the PALM-COEIN system for the classification of abnormal uterine bleeding (AUB) in low-resource settings and to suggest modifications. METHODS: A prospective study was conducted among women with AUB who were admitted to the gynecology ward of a tertiary care hospital and research center in central India between November 2014 and October 2016. All patients were managed as per department protocols. The causes of AUB were classified before treatment using the PALM-COEIN system (classification I) and on the basis of the histopathology reports of the hysterectomy specimens (classification II); the results were compared using classification II as the gold standard...
November 15, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29128204/uterine-artery-embolization-a-review-of-current-concepts
#2
REVIEW
Jonathan J Keung, James B Spies, Theresa M Caridi
Uterine artery embolization (UAE) has gained traction as a safe and effective treatment modality for symptomatic uterine leiomyomata since its introduction nearly two decades ago. This review includes an overview of current concepts with regard to patient selection, technique, and outcomes following UAE. Specific topics also include the impact of this procedure on fertility and pregnancy, the emerging role of UAE in the treatment of adenomyosis, and how UAE compares with surgical intervention for the treatment of symptomatic leiomyomata...
September 29, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29126882/the-role-of-mri-dti-in-predicting-pain-related-to-endometriosis-a-preliminary-study
#3
Maria Grazia Porpora, Valeria Vinci, Corrado De Vito, Giuseppe Migliara, Emanuela Anastasi, Adele Ticino, Serena Resta, Carlo Catalano, Pierluigi Benedetti Panici, Lucia Manganaro
OBJECTIVE: To evaluate the sacral nerve root features by the means of Magnetic Resonance Imaging Diffusion Tensor Imaging (MRI-DTI) tractography in women with endometriosis and /or adenomyosis and to analyze the correlation between DTI abnormalities, pain symptoms, and endometriotic lesions found at surgery. DESIGN: A cross-sectional, observational study (Canadian Task Force classification II-2) SETTING: University hospital PATIENTS: 76 women with clinical suspicion of endometriosis ...
November 7, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29115118/adenomyosis-fertility-and-obstetric-outcome-a-comprehensive-literature-review
#4
Laura Buggio, Ermelinda Monti, Umberto Gattei, Dhohua Dridi, Paolo Vercellini
Adenomyosis is a benign condition characterized by the presence of endometrial glands and stroma deep within the myometrium. In recent years, the potential negative impact of adenomyosis on in vitro fertilization clinical outcomes has gained momentum, as well as, the possible link of this condition with obstetrical complications. The aim of this narrative review is to elucidate the possible association between uterine adenomyosis, infertility, and poor obstetrical outcomes. Several theories have been proposed to clarify the potential harmful impact of adenomyosis on fertility, such as a functional and structural defect of both the eutopic endometrium and the inner myometrium, an impairment of the uterine system of sperm transport, the presence of uterine dysperistalsis and of high levels of free radicals in the uterine milieu of women with the disease...
November 7, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/29112637/improving-ultrasound-detection-of-uterine-adenomyosis-through-computational-texture-analysis
#5
Joseph Konrad, Derek Merck, Jie Ying Wu, Adam Tuomi, Michael Beland
The purpose of our study was to determine if a textural analysis metric can be implemented to improve diagnosis of adenomyosis by ultrasound.We retrospectively identified 38 patients with a magnetic resonance imaging (MRI) diagnosis of uterine adenomyosis that also had a pelvic ultrasound within 6 months. We also identified 50 normal pelvic ultrasound examinations confirmed by a normal pelvic MRI within 6 months as a control group. A region of interest (ROI) was subsequently placed on the study population ultrasound image corresponding to the area of adenomyosis on MRI...
November 6, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29109960/expression-pattern-of-g-protein-coupled-estrogen-receptor-in-myometrium-of-uteri-with-and-without-adenomyosis
#6
Jin-Jiao Li, Hua Duan, Sha Wang, Fu-Qing Sun, Lu Gan, Yi-Qun Tang, Qian Xu, Tin-Chiu Li
Objective: To compare the expression of G-protein-coupled estrogen receptor (GPER) in the junctional zone and outer myometrium of the proliferative and secretory phases of women with and without adenomyosis. Methods: A total of 76 women were included in this study, 42 with adenomyosis (proliferative phase, n = 23; secretory phases, n = 19) and 34 controls (proliferative phase, n = 16; secretory phases, n = 18). Protein and total RNA were extracted from the junctional zone (JZ) and outer myometrium (OM)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29108806/cerebral-infarcts-by-nonbacterial-thrombotic-endocarditis-associated-with-adenomyosis-a-case-report
#7
Byungseok Kim, Seong-Hoon Kim, Taewon Kim
We report a case of multiple embolic cerebral infarcts associated with nonbacterial thrombotic endocarditis (NBTE) in a patient with adenomyosis. The patient presented with dysarthria, left perioral sensory change, and left-hand weakness. Magnetic resonance imaging revealed multiple vascular territory infarctions involving the bilateral cerebellum and the right precentral gyrus. Magnetic resonance angiography was normal. d-Dimer, carbohydrate antigen (CA) 19-9, and CA125 levels were elevated. Abdominal and pelvic computed tomography with iodine contrast enhancement revealed a huge adenomyosis with left ovarian cyst...
November 3, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29102541/nonbacterial-thrombotic-endocarditis-complicated-by-cerebral-infarction-in-a-patient-with-adenomyosis-with-high-serum-ca125-level-a-case-report
#8
Kenji Uchino, Takahiro Shimizu, Heisuke Mizukami, Kenji Isahaya, Hana Ogura, Kensuke Shinohara, Yasuhiro Hasegawa
We report a case of a 48-year-old woman with multiple cerebral infarctions caused by nonbacterial thrombotic endocarditis (NBTE) because of adenomyosis with high serum carbohydrate antigen (CA)125 level. Transesophageal echocardiography (TEE) showed a vegetation, 4 mm in diameter, adjacent to the anterior leaflet of the mitral valve on day 2. Soluble CA125 level was elevated to 901 U/mL. Intravenous infusion of unfractionated heparin sodium was started. On day 35, TEE revealed reduction of the vegetation in size, 2 mm in diameter...
November 1, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29100623/pathogenesis-of-deep-endometriosis
#9
REVIEW
Stephan Gordts, Philippe Koninckx, Ivo Brosens
The pathophysiology of (deep) endometriosis is still unclear. As originally suggested by Cullen, change the definition "deeper than 5 mm" to "adenomyosis externa." With the discovery of the old European literature on uterine bleeding in 5%-10% of the neonates and histologic evidence that the bleeding represents decidual shedding, it is postulated/hypothesized that endometrial stem/progenitor cells, implanted in the pelvic cavity after birth, may be at the origin of adolescent and even the occasionally premenarcheal pelvic endometriosis...
October 31, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29098162/sonographic-signs-of-adenomyosis-are-prevalent-in-women-undergoing-surgery-for-endometriosis-and-may-suggest-a-higher-risk-of-infertility
#10
Vered H Eisenberg, Nissim Arbib, Eyal Schiff, Motti Goldenberg, Daniel S Seidman, David Soriano
Objectives: To determine the prevalence of ultrasound features suggestive of adenomyosis in women undergoing surgery for endometriosis compared with a control group of healthy women without endometriosis. Methods: Retrospective case-control study comparing women with intractable pain or infertility, who underwent transvaginal ultrasound and subsequent laparoscopic surgery, with a control group of healthy women without a previous history of endometriosis. A diagnosis of adenomyosis on TVUS was made based on asymmetrical myometrial thickening, linear striations, myometrial cysts, hyperechoic islands, irregular endometrial-myometrial junction, parallel shadowing, and localized adenomyomas and analyzed for one sign and for three or more signs...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29096350/endometrioid-adenocarcinoma-originating-simultaneously-from-endometrium-sites-of-adenomyosis-and-ovarian-endometriosis-a-case-report-and-review-of-our-cancer-database
#11
Lena Tashima, Kensuke Hori, Hitomi Ono, Teruaki Nagano, Shin-Ichi Nakatsuka, Kimihiko Ito
INTRODUCTION: Although adenomyosis is a common disease, it is a relatively rare site for cancer origin. On the other hand, chocolate cysts have the potential to develop into cancer. We report a case of endometrioid adenocarcinoma occurred at three sites simultaneously; uterine endometrium, adenomyosis and ovarian endometriosis. PRESENTATION OF CASE: A 51-year-old woman underwent total hysterectomy and bilateral salpingo-oophorectomy after a diagnosis of corpus cancer (endometrioid adenocarcinoma, G1) stage IA...
October 30, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29081156/-role-of-oral-contraceptives-in-preventing-endometriosis-related-pain-progression
#12
D L Kong, H Y Guo, X T Han, J S Han, L F Zhang
Objective: To analyze the effect of oral contraceptives on dysmenorrhea in patients with endometriosis. Methods: We designed dysmenorrhea and chronic pelvic pain questionnaire.From February 2014 to February 2016 in the Gynecological Department of Peking University Third Hospital, patients suffered dysmenorrhea with or without endometriosis or adenomyosis were included.According to their own willingness, patients were divided into the research group and the control group.The research group periodically took oral contraceptives (Diane-35 or Yasmin), while the control group received no treatment...
October 24, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29074037/high-intensity-focused-ultrasound-therapy
#13
REVIEW
Vincent Y T Cheung
High-intensity focused ultrasound therapy has received increasing interest in the management of benign uterine tumors. Either magnetic resonance or ultrasound imaging has been used to target and monitor the ablation process. This article provides an overview of the background, clinical use, treatment outcomes, and safety of high-intensity focused ultrasound in the treatment of uterine fibroids and adenomyosis, including a summary of clinical trials comparing magnetic resonance- or ultrasound-guided high-intensity focused ultrasound with other minimally invasive or surgical interventions...
October 3, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29069006/malignant-changes-in-adenomyosis-in-patients-with-endometrial-adenocarcinoma-a-case-series
#14
Xuemei Mao, Wei Zheng, Weibo Mao
The aim of the study is to describe the clinical characteristics and prognosis of malignant transformation of adenomyosis in patients with endometrial cancer.In this retrospective descriptive study, the clinical data of patients with endometrial cancer (n = 127) who were admitted at our hospital between January 2006 and December 2013 were evaluated.Among the 127 patients with endometrial cancer, 24 patients had endometrial cancer concurrently with adenomyosis. Among these 24 patients, 3 were diagnosed with malignant transformation of adenomyosis...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29046066/treatment-options-and-reproductive-outcome-for-adenomyosis-associated-infertility
#15
Ilaria Soave, Jean-Marie Wenger, Nicola Pluchino, Roberto Marci
Adenomyosis is a benign gynecological disease mostly diagnosed in the fourth and fifth decades. The recent improvement of the diagnostic tools and a better understanding of the pathology allowed clinicians to postulate a possible relationship between adenomyosis and infertility and to diagnose it in younger asymptomatic women during infertility work-up. The exact link between adenomyosis and infertility is still not fully established, but recent studies suggest a possible negative effect on female fertility...
October 19, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29043703/the-effects-of-dienogest-on-macrophage-and-natural-killer-cells-in-adenomyosis-a-randomized-controlled-study
#16
Saowapak Prathoomthong, Yada Tingthanatikul, Srithean Lertvikool, Nittaya Rodratn, Wanwisa Waiyaput, Kanthanadon Dittharot, Morakot Sroyraya, Areepan Sophonsritsuk
Background: Progestin has been used for symptomatic treatment of adenomyosis, although its effect on the immune system has not been studied. The aim of this study was to investigate the changes of macrophage and natural killer (NK) cell infiltration in tissues obtained from women with adenomyosis who did or did not receive oral progestin dienogest. MATERIALS AND METHODS: In this randomized controlled clinical trial study, 24 patients with adenomyosis who required hysterectomy were enrolled...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29042983/microrna-17-downregulates-expression-of-the-pten-gene-to-promote-the-occurrence-and-development-of-adenomyosis
#17
Haiyan Hu, Huijuan Li, Yuanli He
The aim of the current study was to evaluate the expression of microRNA (miR)-17 in the endometrial tissues of patients with adenomyosis (AM) and determine its biological function in the occurrence and development of the disease. A total of 45 fresh endometrial tissues of AM patients and 32 normal endometrial tissues were collected from healthy controls. The expression of miR-17 was evaluated using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The miR-17-targeting gene phosphatase and tensin homolog (PTEN) was predicted using bioinformatics and its expression was evaluated with RT-qPCR and western blot analysis...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29042534/the-microbiota-continuum-along-the-female-reproductive-tract-and-its-relation-to-uterine-related-diseases
#18
Chen Chen, Xiaolei Song, Weixia Wei, Huanzi Zhong, Juanjuan Dai, Zhou Lan, Fei Li, Xinlei Yu, Qiang Feng, Zirong Wang, Hailiang Xie, Xiaomin Chen, Chunwei Zeng, Bo Wen, Liping Zeng, Hui Du, Huiru Tang, Changlu Xu, Yan Xia, Huihua Xia, Huanming Yang, Jian Wang, Jun Wang, Lise Madsen, Susanne Brix, Karsten Kristiansen, Xun Xu, Junhua Li, Ruifang Wu, Huijue Jia
Reports on bacteria detected in maternal fluids during pregnancy are typically associated with adverse consequences, and whether the female reproductive tract harbours distinct microbial communities beyond the vagina has been a matter of debate. Here we systematically sample the microbiota within the female reproductive tract in 110 women of reproductive age, and examine the nature of colonisation by 16S rRNA gene amplicon sequencing and cultivation. We find distinct microbial communities in cervical canal, uterus, fallopian tubes and peritoneal fluid, differing from that of the vagina...
October 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/29040564/n-cadherin-identifies-human-endometrial-epithelial-progenitor-cells-by-in-vitro-stem-cell-assays
#19
Hong P T Nguyen, L Xiao, James A Deane, Ker-Sin Tan, Fiona L Cousins, Hirotaka Masuda, Carl N Sprung, Anna Rosamilia, Caroline E Gargett
STUDY QUESTION: Is there a specific surface marker that identifies human endometrial epithelial progenitor cells with adult stem cell activity using in vitro assays? SUMMARY ANSWER: N-cadherin isolates clonogenic, self-renewing human endometrial epithelial progenitor cells with high proliferative potential that differentiate into cytokeratin+ gland-like structures in vitro and identifies their location in some cells of gland profiles predominantly in basalis endometrium adjacent to the myometrium...
November 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29040186/the-effect-of-adenomyosis-in-myometrial-invasion-and-overall-survival-in-endometrial-cancer
#20
Selçuk Erkilinç, Enes Taylan, Varol Gülseren, Gamze Erkilinç, Tuğba Karadeniz, Mustafa Bağci, Orhan Temel, Ulaş Solmaz, Mehmet Gökçü, Muzaffer Sanci
AIM: The aim of this study was to evaluate whether adenomyosis had an effect on myometrial tumor invasion, stage of the disease, and survival in endometrial cancer. METHODS: Endometrial cancer patients encountered between 2007 and 2016 were identified from pathology records. Patients who underwent suboptimal surgical or medical treatment or with insufficient clinical or surgical data were excluded. Patients diagnosed as having concurrent adenomyosis constituted the study group...
October 17, 2017: International Journal of Gynecological Cancer
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