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https://www.readbyqxmd.com/read/29763636/inhibition-of-cox-2-mpges-1-and-5-lox-in-macrophages-by-leonurine-ameliorates-monosodium-urate-crystal-induced-inflammation
#1
Yanzhuo Liu, Chenfan Duan, Honglei Chen, Chenlong Wang, Xiaoxiao Liu, Miao Qiu, Honglin Tang, Feng Zhang, Xiaoyang Zhou, Jing Yang
Cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX) and microsomal prostaglandin E synthase-1 (mPGES-1)-derived eicosanoids play an essential role in human inflammatory disorders. Here, we investigated whether inhibition of COX-2/mPGES-1 and 5-LOX in macrophages by leonurine ameliorates monosodium urate (MSU) crystal-induced inflammation. Virtual screening assay and in vitro enzyme inhibition assay showed that leonurine was a potential inhibitor of COX-2, mPGES-1 and 5-LOX. Compared with COX-2 inhibitor celecoxib, leonurine (30 mg/kg) significantly decreased ankle perimeter, gait score and neutrophil number in synovial fluid in MSU crystal-treated rats, accompanied with the decreased expression of COX-2, mPGES-1 and 5-LOX and production of prostaglandin E2 (PGE2 ) and leukotriene B4 (LTB4 ) in the synovial fluid macrophages...
May 15, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29762881/colchicine-a-microtubule-disassembling-drug-in-the-therapy-of-cardiovascular-diseases
#2
George N Chaldakov
Colchicum autumnale, from which colchicine has been isolated more than 100 years ago, has been used as a treatment for pain and swelling for thousands of years. It is one of the few drugs known from that time period whose use has survived to modernity. Over the past decades, advances in the knowledge of (i) cytoskeletal microtubules (МТ), and (ii) anti-inflammatory and anti-fibrotic effects of colchicine, a classical MT-disassembling (tubulin-targeting) agent, have led to potential new uses for this very old drug extended beyond acute gouty arthritis and familial Mediterranean fever...
May 15, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29759121/diagnosis-and-treatment-of-gout-and-pseudogout-for-everyday-practice
#3
REVIEW
Anthony Sidari, Erica Hill
Gout and pseudogout are crystalline arthropathies commonly seen in primary care. It is important to understand their pathophysiology to facilitate recognition and appropriate treatment. Prompt gouty arthritis treatment relieves short-term suffering. Long-term treatment with urate-lowering therapy prevents recurrent attacks and is generally well-tolerated though flare risk is increased during treatment initiation. When anti-inflammatory medications are prescribed, the flare risk is low. Pseudogout acute treatment is similar to acute gouty arthritis treatment...
June 2018: Primary Care
https://www.readbyqxmd.com/read/29734978/risk-of-nephrolithiasis-in-patients-with-sleep-apnea-a-population-based-cohort-study
#4
Sheng-Han Tsai, Marshall L Stoller, Benjamin A Sherer, Zi-Hao Chao, Tao-Hsin Tung
STUDY OBJECTIVES: To delineate the relationship between sleep apnea and subsequent risk of nephrolithiasis. METHODS: We conducted a retrospective cohort analysis of a general population sample from Taiwan National Health Insurance Research Database (NHIRD) from January 1, 2000 to December 31, 2012. Patients with sleep apnea without prior diagnosis of nephrolithiasis (n = 7,831) were identified and subsequent development of nephrolithiasis was compared to an age- and sex-matched control group (n = 31,293) without sleep apnea...
April 30, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29703511/validation-of-musculoskeletal-ultrasound-in-the-assessment-of-experimental-gout-synovitis
#5
Esperanza Naredo, Juan Pablo Medina, Sandra Pérez-Baos, Aranzazu Mediero, Gabriel Herrero-Beaumont, Raquel Largo
The objective of this study was to validate musculoskeletal ultrasound (US) in a rabbit model of acute gout. Acute gout was induced by intra-articular injection of monosodium urate (MSU) crystals in 10 rabbits; the 3 controls received vehicle. Rabbit knees were assessed by B-mode and power Doppler (PD) US 24 and 72 h after injections. After 72 h, all rabbits were euthanized. US discriminated between the MSU-injected and control groups with respect to the different inflammatory findings at both at 24 and 72 h and for MSU crystal-related findings after 24 h of injection...
April 24, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29702022/acute-gouty-knee-arthritis-ultrasound-findings-compared-with-dual-energy-ct-findings
#6
S Strobl, E J Halpern, M Abd Ellah, C Kremser, J Gruber, R Bellmann-Weiler, C Deml, A Schmalzl, S Rauch, A S Klauser
OBJECTIVE: The purpose of this study was to compare findings of ultrasound (US) with dual-energy CT (DECT) findings in patients presenting with suspected gouty knee arthritis. SUBJECTS AND METHODS: This prospective study included 65 patients (52 men and 13 women; median age, 61.7 years [range, 38-87 years]) with an initial clinical diagnosis of acute gouty knee arthritis who underwent DECT performed using a 128-MDCT scanner and US performed using a 5-18-MHz transducer...
April 27, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29690705/-comparison-of-bone-destruction-markers-in-patients-with-gouty-arthritis-under-different-musculoskeletal-ultrasonic-manifestations
#7
Y N Fei, S M Tang, G Zhang, Y H Li, M Shao, L F Xie, Y C Zhong, X W Zhang
Objectives: To observe the correlation between the different ultrasonic manifestations of gouty arthritis and the indexes of bone destruction (Dickkopf-1, RANKL), in order to further explore the role of musculoskeletal ultrasonography in the diagnosis and monitoring of gouty arthritis. Methods: 160 cases of gouty arthritis from clinic of the Department of Rheumatology of Peking University People's Hospital between July 2016 and June 2017 were recruited in this study. These patients were examined by musculoskeletal ultrasonography (bilateral first metatarsophalangeal joints, bilateral ankle joints and bilateral knee joints)...
April 3, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29686531/-artemisia-extract-suppresses-nlrp3-and-aim2-inflammasome-activation-by-inhibition-of-asc-phosphorylation
#8
Su-Bin Kwak, Sushruta Koppula, Eun-Jung In, Xiao Sun, Young-Kyu Kim, Myong-Ki Kim, Kwang-Ho Lee, Tae-Bong Kang
Artemisia princeps var. orientalis (Asteraceae, A. princeps ) is a well-known traditional medicinal herb used for treating various inflammatory disorders in Korea, Japan, China, and other Asian countries. In the present study, we investigated the effects of A. princeps extract (APO) on interleukin- (IL-) 1 β regulation and inflammasome activation in bone marrow-derived macrophages (BMDMs) and monosodium urate- (MSU-) induced peritonitis mouse model in vivo . The APO treatment to BMDMs primed with lipopolysaccharide (LPS) attenuated the NLRP3 and AIM2 inflammasome activation induced by danger signals, such as ATP, nigericin, silica crystals, and poly (dA:dT), respectively...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29679725/achyranthis-bidentatae-radix-enhanced-articular-distribution-and-anti-inflammatory-effect-of-berberine-in-sanmiao-wan-using-an-acute-gouty-arthritis-rat-model
#9
Juan Wu, Jingya Li, Wei Li, Bei Sun, Jin Xie, Wenming Cheng, Qunlin Zhang
ETHNOPHARMACOLOGICAL RELEVANCE: Sanmiao Wan (SMW) has been a basic prescription employed for the treatment for gout in the clinic since Yuan dynasty. Achyranthis bidentatae radix (ABR) is designed as a lower-guiding drug in SMW to augment the articular accumulation of active ingredients and improve the anti-inflammatory effect. AIM OF THE STUDY: Present study was undertaken to investigate the dose-response relationship of berberine in SMW between the articular concentration and anti-inflammatory effect in the knee joint under the lower-guiding of ABR...
April 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29679210/gout-of-hand-and-wrist-the-value-of-us-as-compared-with-dect
#10
Andrea S Klauser, Ethan J Halpern, Sylvia Strobl, Mohamed M H Abd Ellah, Johann Gruber, Rosa Bellmann-Weiler, Thomas Auer, Gudrun Feuchtner, Werner Jaschke
OBJECTIVES: The purpose of this study was to compare findings of ultrasound (US) with dual-energy CT (DECT) in patients presenting with suspected gouty hand and wrist arthritis. METHODS: This prospective study included 180 patients (136 men and 44 women, age range, 31- 94 years; mean age, 65.9 years) with an initial clinical diagnosis of acute gouty arthritis who underwent DECT and US examination. Intra- and extra-articular findings of each modality were tabulated and calculated with DECT as gold standard...
April 20, 2018: European Radiology
https://www.readbyqxmd.com/read/29678187/an-unexpected-cause-of-sacroiliitis-in-a-patient-with-gout-and-chronic-psoriasis-with-inflammatory-arthritis-a-case-report
#11
Safi Alqatari, Roberta Visevic, Nina Marshall, John Ryan, Grainne Murphy
BACKGROUND: Inflammatory back pain is a condition characterized by inflammation of the sacroiliac joints and lower spine. It is frequently seen in patients with spondyloarthropathies like ankylosing spondylitis, psoriatic arthritis, enteropathic arthritis and reactive arthritis. Inflammatory back pain can be caused by many other conditions like infection and crystal deposition such as gout. In this case, it is difficult to specifically identify gout as a cause by ordinary imaging like magnetic resonance imaging (MRI) or ultrasound...
April 20, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29655702/4-2-4-chlorophenyl-1-4-chlorophenyl-amino-ethyl-benzene-1-3-diol-is-a-potential-agent-for-gout-therapy-as-a-dual-inhibitor-of-xod-and-nlrp3
#12
Mengze Zhou, Suning Li, Ling Song, Qinghua Hu, Wentao Liu
BACKGOUND: Gout is an inflammatory arthritis characterized by abrupt self-limiting attacks of inflammation caused by precipitation of monosodium urate crystals (MSU) in the joint. Both anti-hyperuricemia and anti-inflammation could be gout therapeutic strategies, whereas ideal drugs for gout treatment are deficient. PURPOSE: 4-(2-(4-chlorophenyl)-1-((4-chlorophenyl)amino)ethyl)benzene-1, 3-diol (CBED) was obtained from a cluster of deoxybenzoins derivatives synthesized by our research group with potent anti-hyperuricemic and anti-inflammatory activities, which was expected to be a dual inhibitor of xanthine oxidase (XOD) and NOD-like receptor protein 3 (NLRP3)...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29652046/-hydrogalvanic-baths-as-a-method-of-medical-rehabilitation-a-literature-review-and-the-prospects-for-the-clinical-application
#13
I V Borodulina, N G Badalov, A A Mukhina, A O Gushcha
The hydrogalvanic baths provide a tool for the combined application of warm fresh water and low frequency electric current. These procedures are suitable for both systemic and local treatments. The mechanism behind their therapeutic action is based on synergistic effect of two therapeutic agents. This article presents the literature and historical review of the method as well as the current concept of hydrohalvanic therapy. The history of its development is associated with the improvement of the technical equipment and accumulation of clinical experience...
April 9, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29622755/effects-of-pharmacological-reversal-of-hyperuricemia-on-features-of-the-metabolic-syndrome-in-patients-with-gouty-arthritis
#14
Mariana Marin, Naim M Maalouf
Hyperuricemia has been associated in epidemiological studies with the development of obesity, hypertension, insulin resistance and type 2 diabetes. Nevertheless, it remains unclear whether lowering of serum uric acid (UA) alters any of the features of the metabolic syndrome. In this prospective study (ClinicalTrials.gov identifier: NCT01654276), 24 patients with gouty arthritis and hyperuricemia were treated for 6 months with the xanthine oxidase inhibitor febuxostat to lower serum UA to <6 mg/dL. Measurements of 24 hours ambulatory blood pressure (ABP) and serum and urine markers of the metabolic syndrome were measured at baseline and at the end of 6 months of febuxostat...
April 4, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29616658/-gout-a-treatable-condition
#15
Gudrun Arna Johannsdottir, Olafur Palsson, Helgi Jonsson, Bjorn Gudbjornsson
Gout is a disabling and common arthritis with increasing prevalence. Without treatment the disease can cause permanent joint damage. It is commonly associated with the metabolic syndrome but can also be related to a number of life-threatening diseases and their treatments. Gout is often misdiagnosed and its long-term management is suboptimal despite the availability of effective treatments. Recently The American College of Rheumatology (ACR) and European League against Rheumatism (EULAR) released common guidelines for the diagnosis of gout and EULAR updated their guidelines for management...
April 2018: Læknablađiđ
https://www.readbyqxmd.com/read/29595284/-treat-to-target-in-gouty-arthritis
#16
Karel Pavelka
Gout is a crystal-induced, metabolically determined inflammatory rheumatic disease with increasing prevalence. In clinical practice, gout causes frequent diagnostic as well as therapeutic problems. The golden diagnostic standard is crystalographic analysis and evidence of monosodium urate crystals in the polarization microscope; if this is not available, the diagnosis can be established through a combination of clinical, laboratory and imaging techniques. The acute gouty attack must be treated by quick administration of anti-inflammatory medicines, with available alternatives being nonsteroidal antirheumatic drugs (NSA), colchicine and glucocorticoids...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29590701/a-case-of-severe-gouty-tophi-induced-carpal-tunnel-syndrome-operative-finding-and-its-outcome
#17
Jun-Ku Lee, Ju Won Kim, Yoon Seok Kim, Bon San Koo
Gout is a disease featuring acute arthritis, joint deformity and severe pain caused through the deposition of monosodium urate crystals in and around synovial tissue 1. Tophi are stone-like deposits of monosodium urate in the soft tissues, synovial tissues, or bones adjacent to the joints. The tophi can compromise joint motion and deteriorate bony structure, finally leading to functional disability. Therefore, early treatment using uric acid lowering agents is standard practice in gout patients to prevent the formation of tophi through controlling uric acid levels...
February 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29584621/blocking-fatty-acid-fueled-mros-production-within-macrophages-alleviates-acute-gouty-inflammation
#18
Christopher J Hall, Leslie E Sanderson, Lisa M Lawrence, Bregina Pool, Maarten van der Kroef, Elina Ashimbayeva, Denver Britto, Jacquie L Harper, Graham J Lieschke, Jonathan W Astin, Kathryn E Crosier, Nicola Dalbeth, Philip S Crosier
Gout is the most common inflammatory arthritis affecting men. Acute gouty inflammation is triggered by monosodium urate (MSU) crystal deposition in and around joints that activates macrophages into a proinflammatory state, resulting in neutrophil recruitment. A complete understanding of how MSU crystals activate macrophages in vivo has been difficult because of limitations of live imaging this process in traditional animal models. By live imaging the macrophage and neutrophil response to MSU crystals within an intact host (larval zebrafish), we reveal that macrophage activation requires mitochondrial ROS (mROS) generated through fatty acid oxidation...
March 26, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29574941/a-systematic-review-and-meta-analysis-of-randomized-controlled-trials-skin-patch-of-chinese-herbal-medicine-for-patients-with-acute-gouty-arthritis
#19
REVIEW
Huiru Wang, Qiang Fu, Zhe Liu, Menglin Li, Shuangqing Zhai
AIMS: To evaluate the evidence of the effectiveness and safety of Chinese herbal medicine skin-patches for patients with acute gouty arthritis. BACKGROUND: Acute gouty arthritis is a problem that can limit the level of activity and impair the quality of life. In China, many clinical studies have demonstrated that skin-patches of Chinese herbal medicines benefit patients with acute gouty arthritis. However, the reported clinical effects vary. DESIGN: A systematic review and meta-analysis of randomized controlled trials...
March 25, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29544526/mice-with-mir-146a-deficiency-develop-severe-gouty-arthritis-via-dysregulation-of-traf-6-irak-1-and-nalp3-inflammasome
#20
Quan-Bo Zhang, Yu-Feng Qing, Cong-Cong Yin, Li Zhou, Xian-Shuang Liu, Qing-Sheng Mi, Jing-Guo Zhou
BACKGROUND: MicroRNAs (miRNAs) serve as important regulators of inflammatory and immune responses and are implicated in several immune disorders including gouty arthritis. The expression of miR-146a is upregulated in the peripheral blood mononuclear cells of patients with inter-critical gout when compared to normouricemic and hyperuricemic controls and those patients with acute gout flares. However, the role of miR-146a in the development of gout remains unknown. Here, we used miR-146a knockout (KO) mice to test miR-146a function in a monosodium urate (MSU)-induced gouty arthritis model...
March 15, 2018: Arthritis Research & Therapy
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