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https://www.readbyqxmd.com/read/27863506/interleukin-37-limits-monosodium-urate-crystal-induced-innate-immune-responses-in-human-and-murine-models-of-gout
#1
Lei Liu, Yu Xue, Yingfeng Zhu, Dandan Xuan, Xue Yang, Minrui Liang, Juan Wang, Xiaoxia Zhu, Jiong Zhang, Hejian Zou
BACKGROUND: Interleukin (IL)-37 has emerged as a fundamental inhibitor of innate immunity. Acute gout is a self-limiting inflammatory response to monosodium urate (MSU) crystals. In the current study, we assessed the preventive and therapeutic effect of recombinant human IL-37 (rhIL-37) in human and murine gout models. METHODS: We investigated the expression of IL-37 in patients with active and inactive gouty arthritis and assessed the effect of rhIL-37 in human and murine gout models: a human monocyte cell line (THP-1) and human synovial cells (containing macrophage-like and fibroblast-like synoviocytes) exposed to MSU crystals, a peritoneal murine model of gout and a murine gouty arthritis model...
November 18, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27847529/update-on-the-clinical-effect-of-acupuncture-therapy-in-patients-with-gouty-arthritis-systematic-review-and-meta-analysis
#2
REVIEW
Wei-Wei Lu, Jin-Ming Zhang, Zheng-Tao Lv, An-Min Chen
Objective. The aim of this study is to evaluate the clinical efficacy and safety of acupuncture therapy in the treatment of acute gouty arthritis. Methods. A literature search of PubMed, EMBASE, ISI Web of Science, CENTRAL, and CNKI was conducted from the inception date of each database up to October 2015. Two investigators screened each article independently and were blinded to the findings of the other reviewer. Data was extracted according to the predetermined collection form. Meta-analysis was performed...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27845712/the-role-of-mirnas-in-common-inflammatory-arthropathies-osteoarthritis-and-gouty-arthritis
#3
REVIEW
Panagiota Papanagnou, Theodora Stivarou, Maria Tsironi
MicroRNAs (miRNAs) are small, non-coding RNA species that are highly evolutionarily conserved, from higher invertebrates to man. Up to 1000 miRNAs have been identified in human cells thus far, where they are key regulators of the expression of numerous targets at the post-transcriptional level. They are implicated in various processes, including cell differentiation, metabolism, and inflammation. An expanding list of miRNAs is known to be involved in the pathogenesis of common, non-autoimmune inflammatory diseases...
November 11, 2016: Biomolecules
https://www.readbyqxmd.com/read/27835909/impact-of-hla-b-58-01-allele-and-allopurinol-induced-cutaneous-adverse-drug-reactions-evidence-from-21-pharmacogenetic-studies
#4
Ran Wu, Yi-Ju Cheng, Li-Li Zhu, Lei Yu, Xue-Ke Zhao, Min Jia, Chang-Hui Wen, Xing-Zhen Long, Ting Tang, Ai-Juan He, Yi-Yan Zeng, Zun-Feng Ma, Zhi Zheng, Mu-Zi Ni, Gong-Jing Cai
Allopurinol is widely used for hyperuricemia and gouty arthritis, but is associated with cutaneous adverse drug reactions (CADRs). Recently, HLA-B*58:01 allele was identified as a strong genetic marker for allopurinol-induced CADRs in Han Chinese. However, the magnitude of association and diagnosis value of HLA-B*58:01 in allopurinol-induced CADRs remain inconclusive. To investigate this inconsistency, we conducted a meta-analysis of 21 pharmacogenetic studies, including 551 patients with allopurinol-induced CADRs, and 2,370 allopurinol-tolerant controls as well as 9,592 healthy volunteers...
November 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27813564/role-of-il-8-rs4073-and-rs2227306-polymorphisms-in-the-development-of-primary-gouty-arthritis-in-a-chinese-population
#5
Y X Cui, H Zhao, H Q Guo
In this study, we investigated the role of two single nucleotide polymorphisms in the promoter region of the interleukin-8 gene (IL-8; rs4073 and rs2227306) in the susceptibility to primary gouty arthritis in a Chinese population. Three hundred and twelve patients with primary gouty arthritis and 340 healthy controls were recruited from the Yan'an University Affiliated Hospital between January 2014 and March 2015. The IL-8 rs4073 and rs2227306 polymorphisms were genotyped by polymerase chain reaction combined with restriction fragment length polymorphism...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27793273/nasal-gouty-tophus-report-a-rare-case-presenting-as-a-nasal-hump-with-nasal-obstruction
#6
COMMENT
John Chung-Han Wu, Pang-Yun Chou, Chih-Hao Chen
Dorsal nasal gouty tophus are rare occurrences with limited documentation. Here we report a male patient who has a history of poorly controlled gouty arthritis. He had nasal obstruction with an enlarging mass over his left nasal ridge for the past three years. Image studies revealed a nasal bone defect underneath the nasal lesion. The firm mass was excised and confirmed to be of gouty origin. The nasal bone defect was repaired with a titanium mesh plate to prevent nasal depression. He has fully recovered with no more nasal obstruction or recurrence of nasal tophus...
August 2016: Biomedical Journal
https://www.readbyqxmd.com/read/27770227/prevalence-of-comorbidities-and-management-of-gout-in-a-tropical-city-in-australia
#7
Andrew Jeyaruban, Muriel Soden, Sarah Larkins
To examine the management of gout in general practice in Townsville, Australia, and to explore comorbid conditions in patients with gout. Study will also explore how closely guidelines are being followed in managing gout. Retrospective chart review was conducted from May to November 2014 in three general practices in Townsville. Registers for patients were established by searching "gout" and "gouty arthritis". Three hundred and twenty-one patients were included in the study after excluding inactive patients, patients below age of 18 and patients with cancer...
December 2016: Rheumatology International
https://www.readbyqxmd.com/read/27769591/pegloticase-failure-and-a-possible-solution-immunosuppression-to-prevent-intolerance-and-inefficacy-in-patients-with-gout
#8
Adey A Berhanu, Svetlana Krasnokutsky, Robert T Keenan, Michael H Pillinger
INTRODUCTION: Pegloticase is a highly effective therapy for patients with refractory and/or tophaceous gout, but has a high discontinuation rate (30-50%) due to development of anti-drug antibodies causing loss of efficacy and risk of infusion reactions. OBJECTIVE: To describe the use of azathioprine or other immunosuppressive therapies as a pegloticase adjunct to prevent pegloticase immunogenicity when treating gout. METHODS: Case report of azathioprine use in a patient receiving pegloticase therapy for refractory tophaceous gout, and review of the literature for the impact of immunosuppressive agents on development of anti-drug antibodies...
September 20, 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27757263/in-vitro-xanthine-oxidase-and-albumin-denaturation-inhibition-assay-of-barringtonia-racemosa-l-and-total-phenolic-content-analysis-for-potential-anti-inflammatory-use-in-gouty-arthritis
#9
Nurul Izzati Osman, Norrizah Jaafar Sidik, Asmah Awal, Nurul Athirah Mohamad Adam, Nur Inani Rezali
AIM: This study was conducted to evaluate the in vitro anti-inflammatory activities and total phenolic content (TPC) of methanolic extracts of infloresence axes, endosperms, leaves, and pericarps of Barringtonia racemosa L. METHODS: The anti-inflammatory study was conducted by assessing the potential through xanthine oxidase (XO) and albumin denaturation inhibition assays. Meanwhile, the TPC in the extracts were assessed by Folin-Ciocalteu assay. RESULTS: In the XO inhibition assay, the infloresence axes extract was found to exert the highest inhibition capacity at 0...
September 2016: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/27747728/colchicine-induced-acute-neuromyopathy-in-a-patient-using-concomitant-fluconazole-case-report-and-literature-review
#10
Yi-Chia Su, Chih-Chien Wu
A 54-year-old woman presented at the emergency department after experiencing lower limb weakness and bilateral ankle pain for 2 days. She had a history of type 2 diabetes mellitus, diabetes mellitus nephropathy with chronic kidney disease, and chronic gouty arthritis. She had received 0.6 mg colchicine orally once or twice daily for 8 months. Four days prior to her emergency department visit, she was discharged from our nephrology ward, where she had been admitted because of a urinary tract infection. During hospitalization, she was treated with intravenous cefazolin for 7 days...
December 2015: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27730304/-gouty-arthritis
#11
A-K Tausche, M Aringer
Gouty arthritis is the most common form of arthritis in men. As a consequence of persisting hyperuricemia, uric acid crystals are deposited in the intra-articular and periarticular spaces and activate the innate immune system. The clinically impressive abrupt onset monoarticular arthritis in the lower extremities is highly suggestive of a gout attack. Arthrosonography can be used for early detection of crystal deposition on joint cartilage. In synovial fluid the detection of uric acid crystals in polarization microscopy is proof of gout even without the detection of intracellular uric acid crystals...
October 11, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27730254/-rare-manifestations-of-axial-skeleton-gouty-arthropathy
#12
H Bastian, M Worsch, A Huppertz, A Krause, W A Schmidt
Clinical manifestations of gouty arthropathy are usually acute inflammatory arthritis, bursitis and accumulation of urate crystals in the form of tophi. Manifestations on the axial skeleton are also known and have been described but occur infrequently and for this reason play a subordinate role in the awareness of rheumatologists. With dual energy computed tomography (CT) gout tophi can be detected even in unusual regions or regions that are difficult to access for puncturing. We describe two rare cases of gouty arthropathy of the axial skeleton in a 76-year-old male patient with spinal involvement and in a 53-year-old female patient with involvement of the sacroiliac joint...
October 11, 2016: Der Internist
https://www.readbyqxmd.com/read/27699015/association-of-dna-methyltransferase-polymorphisms-with-susceptibility-to-primary-gouty-arthritis
#13
Xiaowu Zhong, Yuanhong Peng, Chengjiao Yao, Yufeng Qing, Qibin Yang, Xiaolan Guo, Wenguang Xie, Mingcai Zhao, Xiaoming Cai, Jing-Guo Zhou
Gouty arthritis is the most common type of inflammatory and immune disease, and the prevalence and incidence of gout increases annually. Genetic variations in the DNA methyltransferases (DNMTs) gene have not, to the best of our knowledge, been reported to influence gene expression and to participate in the pathogenesis of gout. The aim of the present study was to investigate whether the DNMT1, DNMT3A and DNMT3B polymorphisms contribute to gout susceptibility. These polymorphisms were screened for in 336 gout patients and 306 healthy control subjects (from a South China population) for association with gout...
October 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27693802/efficacy-of-coenzymeq10-in-inhibiting-monosodium-urate-crystal-induced-inflammation-in-rats
#14
B Udhaya Lavinya, Ishita Bardhan, Sabina Evan Prince
Gout is a type of arthritis, which could result from the deposition of monosodium urate crystals in joints. It can cause redness, burning pain, inflammation of joints especially in big toe. In this study, we have looked for anti-arthritic effect of coenzyme Q10 (CoQ10) on monosodium urate crystal-induced inflammation in rats and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin. The evaluation was done by measuring the paw volume, antioxidant status, lipid peroxidation, lysosomal enzymes (β-glcuronidase, β-galactosidase, N-acetyl-β-d-glucosaminidase, acid phosphatase) activities and histopathological studies...
September 29, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27689075/effects-of-berberine-on-nlrp3-and-il-1%C3%AE-expressions-in-monocytic-thp-1-cells-with-monosodium-urate-crystals-induced-inflammation
#15
Ya-Fei Liu, Cai-Yu-Zhu Wen, Zhe Chen, Yu Wang, Ying Huang, Sheng-Hao Tu
Background. Urate crystals-induced inflammation is a critical factor during the initiation of gouty arthritis. Berberine is well known for its anti-inflammatory activity. However, the underlying effects of berberine on monosodium urate crystals-induced inflammation remain obscure. Objectives. This study is set to explore the protective effect and mechanism of berberine on monosodium urate crystals-induced inflammation in human monocytic THP-1 cells. Methods. The mRNA levels of NLRP3 and IL-1β were measured by Real-Time PCR, and the protein levels of NLRP3 and IL-1β were determined by ELISA, Western blot, and immunofluorescence...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27687651/-correlation-of-dnase-i-in-serum-and-synovial-fluid-with-inflammatory-activity-in-patients-with-rheumatoid-arthritis
#16
Xia-Yu Xu, Wen-Fang Yang, Si-Gong Zhang, Qin Zhao, Li-Jun Linag, Xin Wang, Hai-Li Shen
OBJECTIVE: To investigate the potential role of deoxyribonuclease I (DNase I) in the pathogenesis of rheumatoid arthritis (RA). METHODS: DNase I activity was measured by radial enzyme-diffusion method in serum samples from 83 RA patients and 60 healthy volunteers and in the synovial fluid (SF) from 27 RA patients and 38 patients with other inflammatory arthritis. SF cfDNA level was measured with Pico Green Kit, and the correlation among DNase I activity, cfDNA level and clinical parameters of RA patients was analyzed...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27666904/pathogenesis-and-clinical-management-of-gouty-arthritis
#17
Renu Saigal, Abhishek Agrawal
Gout, the most common of the crystal arthritides is a result of disturbed uric acid metabolism and precipitation of urate crystals in extra cellular space of joints, periarticular tissue, bones and other organs. In the West, gout affects around 1% of adult men over 45 years of age. The estimated incidence being 0.6 to 2.1 per 1000 per year, with a prevalence of 9.5 to 13.5 per 1000 persons of all ages.1 The incidence of gout has been on rise globally; potentially attributable to recent shifts in diet, lifestyle, medical care, and increased longevity...
December 2015: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27666624/single-source-dual-energy-computed-tomography-in-the-diagnosis-of-gout-diagnostic-reliability-in-comparison-to-digital-radiography-and-conventional-computed-tomography-of-the-feet
#18
Tobias Kiefer, Torsten Diekhoff, Sandra Hermann, Andrea Stroux, Jürgen Mews, Jörg Blobel, Bernd Hamm, Kay-Geert A Hermann
OBJECTIVES: To investigate the diagnostic value of single-source dual-energy computed tomography (SDECT) in gouty arthritis and to compare its capability to detect urate depositions with digital radiography (DR) and conventional computed tomography (CT). METHODS: Forty-four patients who underwent SDECT volume scans of the feet for suspected gouty arthritis were retrospectively analyzed. SDECT, CT (both n=44) and DR (n=36) were scored by three blinded readers for presence of osteoarthritis, erosions, and tophi...
October 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/27660933/detection-of-anti-type-ii-collagen-antibodies-in-patients-with-chronic-gouty-arthritis-findings-from-a-pilot-study
#19
Hyun Ah Kim, Young-Il Seo, Jisoo Lee, Young Ok Jung
OBJECTIVE: We hypothesized that chronic gouty arthritis patients would develop an immune response to type II collagen that would be revealed by the presence of anti-type II collagen (CII) antibodies in serum, which may in turn be involved in progression to non-remitting arthritis. METHODS: Chronic gouty arthritis was defined as crystal-confirmed gout in patients with no pain-free intercritical period, with or without the presence of tophi, who did not have clinical features of other forms of chronic arthritis...
October 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27658418/risk-of-acute-gout-among-active-smokers-data-from-nationwide-inpatient-sample
#20
Dilli Ram Poudel, Paras Karmacharya, Anthony Donato
Smoking has been found to be negatively correlated with serum uric acid levels by virtue of reduced production and increased consumption of endogenous antioxidant uric acid among smokers and has been reported to decrease incidence of gout. To shed further light on the question of association between active smoking and acute gout by examining this association using a large inpatient US database, using the Nationwide Inpatient Sample data from 2009 to 2011, we identified current smokers based on the International Classification of Diseases, Ninth Revision (ICD-9) code 305...
September 22, 2016: Clinical Rheumatology
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