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Thyroid FNA

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https://www.readbyqxmd.com/read/29240898/natural-history-of-contralateral-nodules-after-lobectomy-in-patients-with-papillary-thyroid-carcinoma
#1
Amit Ritter, Gideon Bachar, Dania Hirsch, Carlos Benbassat, Orna Katz, Nadav Kochen, Talia Diker-Cohen, Amit Akirov, Ilan Shimon, Eyal Robenshtok
Background: Bilateral thyroid nodularity is considered an indication for total thyroidectomy in papillary thyroid carcinoma (PTC) patients. However, the natural history and outcome of contralateral nodules has never been studied. Objective: To investigate the natural history of non-suspicious contralateral nodules after lobectomy for PTC. Methods: We included patients who had ≥1 solid nodules (≥3mm) in the contralateral lobe prior to surgery with benign cytology, or small non suspicious nodules per ultrasound...
December 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29234622/impact-of-serum-tsh-and-anti-thyroglobulin-antibody-levels-on-lymph-node-fine-needle-aspiration-thyroglobulin-measurements-in-differentiated-thyroid-cancer-patients
#2
Marta Amaro da Silveira Duval, André Borsatto Zanella, Ana Patrícia Cristo, Carlo Sasso Faccin, Marcia Silva Graudenz, Ana Luiza Maia
Background: Thyroglobulin measurements in the washout of fine needle aspiration (FNA-Tg) are an excellent tool to detect lymph node (LN) metastases of differentiated thyroid carcinoma (DTC). Nevertheless, how to define the best cutoffs and the influence of potential confounders are still being discussed. Objective: To evaluate the accuracy of FNA-Tg measurement to detect DTC metastases and the influence of thyroid status and anti-thyroglobulin antibodies (TgAb)...
November 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29208984/a-nonlinear-approach-to-identify-pathological-change-of-thyroid-nodules-based-on-statistical-analysis-of-ultrasound-rf-signals
#3
Huan Xu, Chunrui Liu, Ping Yang, Juan Tu, Bin Yang, Dong Zhang
In order to reassure the majority of patients with benign nodules from unnecessary needle biopsy, there is an increasing clinical requirement to identify benign and malignant thyroid nodules during ultrasound diagnosis. A nonlinear approach based on statistical analysis of ultrasound radio-frequency (RF) signals was developed for differential diagnosing the thyroid nodules to improve the diagnostic accuracy. Data from 44 patients with solitary thyroid nodules were collected, following with the ultrasound-guided fine needle aspiration (FNA) as the ground truth...
December 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29205587/the-impact-of-repeat-fna-in-non-diagnostic-and-indeterminate-thyroid-nodules-a-5-year-single-centre-experience
#4
M A Saieg, B Barbosa, J Nishi, A Ferrari, F Costa
INTRODUCTION: FNA is a well-established method for the preoperative diagnosis of thyroid nodules, but limitations still reside among non-diagnostic and indeterminate samples. The objective of the present study was to assess the impact of repeat FNA in thyroid nodules primarily classified as non-diagnostic and indeterminate, with the evaluation of the diagnostic resolution rate after the reassessment of the nodule. METHODS: We retrospectively collected all cases of thyroid FNA at our institution in the last 5 years that had one or more repeat aspirations of the same nodule, calculating the percentage of samples with change in the diagnostic category...
December 4, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29201471/metastatic-renal-cell-cancer-to-thyroid-diagnosed-by-endoscopic-ultrasound-guided-fine-needle-aspiration-technique
#5
Yousef Abdel-Aziz, Tariq Hammad, Mohamad Nawras, Hayder Abdulwahid, Ali Nawras
Medical literature about the role of endoscopic ultrasound (EUS) in identifying thyroid lesions is limited. We present a case of secondary thyroid cancer from renal cell carcinoma (RCC) metastasis, diagnosed by thyroid EUS-fine needle aspiration (FNA) approach that was done for staging of esophageal adenocarcinoma, in a patient with 11-year history of complete right nephrectomy for RCC. An 81-year-old female patient underwent EUS for the evaluation of a newly discovered distal esophageal cancer. A hypoechoic, round, and well-demarcated mass that measured 26...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29201322/the-diagnostic-value-of-fine-needle-aspiration-in-comparison-with-frozen-section-in-thyroid-nodules-a-20-year-study
#6
Sepideh Siadati, Seyed Mozafar Rabiee, Ebrahim Alijanpour, Mohammad Ali Bayani, Novin Nikbakhsh
Background: Fine needle aspiration (FNA) is the most important method in the diagnosis of thyroid nodules before surgery. Recently, the efficiency of FNA in thyroid nodule management has been debatable. On the other hand, intraoperative frozen section (FS) has been used to confirm the diagnosis of FNA and select the proper surgical approach. In this regard, the present study aimed to assess the diagnostic value of FNA as compared to FS in the diagnosis of thyroid nodules. Methods: This retrospective study was performed on 69 patients with FNA and FS and histopathological examination from 1993 to 2014 in Babol, northern Iran...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29196301/interobserver-agreement-of-various-thyroid-imaging-reporting-and-data-systems
#7
Giorgio Grani, Livia Lamartina, Vito Cantisani, Marianna Maranghi, Piernatale Lucia, Cosimo Durante
Ultrasonography is the best available tool for the initial work-up of thyroid nodules. Substantial interobserver variability has been documented in the recognition and reporting of some of the lesion characteristics. A number of classification systems have been developed to estimate the likelihood of malignancy: several of them have been endorsed by scientific societies, but their reproducibility has yet to be assessed. We evaluated the interobserver variability of the AACE/ACE/AME, ACR, ATA, EU-TIRADS, and K-TIRADS classification systems and the interobserver concordance in the indication to FNA biopsy...
December 1, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/29193839/implementing-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-may-potentially-impact-the-risk-of-malignancy-for-thyroid-nodules-categorized-as-aus-flus-and-fn-sfn
#8
Weihong Li, Andrew Sciallis, Madelyn Lew, Judy Pang, Xin Jing
BACKGROUND: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) has recently been reclassified as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). Implementation of the new terminology may alter the implied risk of malignancy (ROM) across the six categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). METHODS: The study cohort consisted of thyroid fine needle aspiration (FNA) cases which were assessed between January 2011 and June 2016 and led to surgical resections...
November 30, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29175058/instituting-ultrasound-guided-fna-for-thyroid-nodules-into-a-general-surgery-residency-program-what-we-learned
#9
James R Davis, Allyson L Hale, Joseph A Ewing, Jonathan S Lokey
BACKGROUND: Evaluation of a thyroid nodule is a common referral seen by surgeons and frequently requires ultrasound-guided fine needle aspiration (US-guided FNA). While surgical residents may have sufficient exposure to thyroid surgery, many lack exposure to office-based procedures, such as US-guided FNA. General surgery residents should be provided with knowledge and practical skills in the application of diagnostic and interventional neck ultrasound to manage the common workup of a thyroid nodule...
November 22, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/29174930/the-use-of-fine-needle-aspiration-and-trends-in-incidence-of-thyroid-cancer-in-taiwan
#10
Kang-Lung Lee, Tzeng-Ji Chen, Ging-Shing Won, Yi-Hong Chou, Hong-Jen Chiou, Hsin-Kai Wang, Yi-Chen Lai, Yung-Hui Lin, Jane Wang
BACKGROUND: Thyroid cancer is the most prevalent endocrine malignancy, and the incidence of thyroid cancer has increased worldwide. Fine needle aspiration (FNA) for cytology of thyroid tissue is used for differentiating thyroid cancers from benign thyroid nodules. Overuse of FNA may detect subclinical thyroid cancer and play a role in the increased incidence of thyroid cancer. The aim of this study was to evaluate trends in incidence of thyroid cancer and the use of palpation-guided FNA thyroid and ultrasound-guided FNA thyroid in Taiwan...
November 22, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29167761/european-thyroid-association-guidelines-for-ultrasound-malignancy-risk-stratification-of-thyroid-nodules-in-adults-the-eu-tirads
#11
Gilles Russ, Steen J Bonnema, Murat Faik Erdogan, Cosimo Durante, Rose Ngu, Laurence Leenhardt
Thyroid ultrasound (US) is a key examination for the management of thyroid nodules. Thyroid US is easily accessible, noninvasive, and cost-effective, and is a mandatory step in the workup of thyroid nodules. The main disadvantage of the method is that it is operator dependent. Thyroid US assessment of the risk of malignancy is crucial in patients with nodules, in order to select those who should have a fine needle aspiration (FNA) biopsy performed. Due to the pivotal role of thyroid US in the management of patients with nodules, the European Thyroid Association convened a panel of international experts to set up European guidelines on US risk stratification of thyroid nodules...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29165888/molecular-pathology-and-thyroid-fna
#12
REVIEW
D N Poller, S Glaysher
This review summarises molecular pathological techniques applicable to thyroid FNA. The molecular pathology of thyroid tumours is now fairly well understood. Molecular methods may be used as a rule-in test for diagnosis of malignancy in thyroid nodules, eg BRAF V600E point mutation, use of a seven-gene mutational panel (BRAF V600E, RAS genes, RET/PTC or PAX8/PPARG rearrangement), or as a comprehensive multigene next-generation sequencing panel, eg ThyroSeq v2. Molecular methods can also be applied as rule-out tests for malignancy in thyroid nodules, eg Afirma or ThyroSeq v2 or as markers of prognosis, eg TERT promoter mutation or other gene mutations including BRAF V600E, TP53 and AKT1, and as tests for newly defined tumour entities such as non-invasive follicular thyroid neoplasm with papillary like nuclei, or as a molecular marker(s) for targeted therapies...
December 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29165886/pre-operative-features-of-non-invasive-follicular-thyroid-neoplasms-with-papillary-like-nuclear-features-an-analysis-of-their-cytological-gene-expression-classifier-and-sonographic-findings
#13
S J Song, V A LiVolsi, K Montone, Z Baloch
OBJECTIVE: To investigate the corresponding cytological diagnoses, Gene Expression Classifier (GEC) results and ultrasound features of thyroid nodules diagnosed as non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP), as well as any coexisting pathology. METHODS: We performed a retrospective review of thyroid nodules histologically diagnosed as NIFTP at our institution between 1st April 2016 and 1st April 2017. The following data points were collected: demographics, nodule size, ultrasound features, cytological diagnosis, GEC results, origin of sample (in-house vs outside hospital) and any additional pathology identified in the resection specimen...
December 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29163353/primary-ewing-sarcoma-of-the-thyroid-eight-cases-in-a-decade-a-case-report-and-literature-review
#14
Paweł Kabata, Sonia Kaniuka-Jakubowska, Wanda Kabata, Joanna Lakomy, Wojciech Biernat, Krzysztof Sworczak, Janusz Jaśkiewicz, Maciej Świerblewski
Sarcomas represent less than 1% of all malignant tumors found in the thyroid. Of these, primary extraosseoussarcoma has been reported only a few times in the past decade. We present the case of a 34-year-old male who had a fast-growing hard mass in the lower left neck. FNA was inconclusive. Core needle biopsy revealed the diagnosis of an Ewing sarcoma/primitive neuroectodermal tumor. Mutation of EWSR1 was confirmed using the FISH method. Following treatment by neoadjuvant chemotherapy, we observed clinical, radiological, and finally histopathological remission...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29161789/current-status-of-thyroid-fine-needle-aspiration-practice-in-thailand
#15
REVIEW
Somboon Keelawat, Samreung Rangdaeng, Supinda Koonmee, Tikamporn Jitpasutham, Andrey Bychkov
Thyroid carcinoma is one of the leading malignancies in Thailand increasingly prevalent in the female population. Fine-needle aspiration (FNA) cytology is a widely used diagnostic tool for evaluation of thyroid nodules and thyroid cancer. Thyroid FNA is a routine procedure universally performed in Thai hospitals by a variety of clinical specialists. Manual guidance is the first-line choice complemented by ultrasound assistance in selected cases. Despite national guidelines recommendations, the diagnostic criteria and terminology of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was slowly adopted in the local settings...
November 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29151299/eleven-patients-with-primary-thyroid-lymphoma-a-single-center-experience
#16
Hasan Bostancı, Kürşat Dikmen, Nalan Akyürek, Ahmet Çağrı Büyükkasap, Aydın Yavuz, Mehmet Muhittin Yalçın, Murat Akın
Background/aim: Primary thyroid lymphoma (PTL) is a very rare thyroid malignancy. It should be diagnosed and treated immediately and accurately. Our aim was to evaluate the diagnostic methods and treatment results for patients with PTL.Materials and methods: We retrospectively evaluated the records of 11 patients with PTL from 2009 to 2015, diagnosed at our institute. Age, sex, stage, histopathologic type, presence of Hashimoto's thyroiditis, diagnostic methods, treatment types, and recurrence were examined...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29145304/partially-cystic-thyroid-nodules-in-ultrasound-guided-fine-needle-aspiration-prevalence-of-thyroid-carcinoma-and-ultrasound-features
#17
Wenbo Li, Qingli Zhu, Yuxin Jiang, Qing Zhang, Zhilan Meng, Jian Sun, Jianchu Li, Qing Dai
Partially cystic thyroid nodules (PCTNs) are common on ultrasound (US). However, there are insufficient data on the prevalence of thyroid carcinoma among such nodules. The purpose of this study was thus to evaluate the prevalence and differentiation of partially cystic thyroid cancers in US-guided fine needle aspiration (FNA).A total of 1342 consecutive patients with 1360 thyroid nodules underwent prospective US diagnosis and FNA biopsy. In total, 281 nodules (20.7%) were partially cystic lesions. The nodules were prospectively analyzed based on US features (ie, solid portion positions, shapes, margins, and microcalcifications) and US diagnosis (benign, suspicious, or malignant)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137498/core-needle-biopsy-of-thyroid-nodules-outcomes-and-safety-from-a-large-single-center-single-operator-study
#18
Jooae Choe, Jung Hwan Baek, Hye Sun Park, Young Jun Choi, Jeong Hyun Lee
Background There currently remains a debate over the use of core needle biopsy (CNB) or fine needle aspiration (FNA) for diagnosis of thyroid nodules. The major drawbacks of previous CNB studies include heterogeneity of the study population, variable techniques, devices, and operator experience affecting the outcome of the procedure. Purpose To assess the diagnostic performance and safety of CNB of thyroid nodules performed by a single experienced operator in consecutive patients. Material and Methods From January 2012 to December 2012, 538 thyroid nodules that underwent CNB were retrospectively evaluated...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/29137384/mir-324-5p-assists-ultrasonography-in-predicting-lymph-node-metastasis-of-unifocal-papillary-thyroid-microcarcinoma-without-extracapsular-spread
#19
Yanhua Yang, Shujun Xia, Xiaofeng Ni, Zhongxin Ni, Lu Zhang, Wenhan Wang, Yanjun Kong, Yan Wang, Lei Ye, Weiwei Zhan
Ultrasonography is the first choice of lymph node metastasis (LNM) detection which is crucial for therapeutic options of papillary thyroid cancer (PTC). However, the sensitivity of ultrasonography in detecting LNM of PTC is relatively low; especially in central LNM. MiR-324-5p has been reported to play important roles in the metastasis of various cancers. To explore the relationship between miR-324-5p and LNM in PTC, quantitative real-time polymerase chain reaction was performed in PTC tissue and fine needle aspiration (FNA) washout successively...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137085/current-trends-of-practical-issues-concerning-micropapillary-thyroid-carcinoma-the-korean-society-of-thyroid-head-and-neck-surgery
#20
Yoon Se Lee, Byung-Joo Lee, Hyun Joon Hong, Kang-Dae Lee
Although several thyroid associations have published various guidelines, controversies especially in cases of micropapillary thyroid cancer (MPTC) still exist. This survey was designed to collect information about diagnostic tests and treatments performed on patients with MPTC and help identify current trends in thyroid surgery.We developed questionnaires about the management methods for MPTC, which were used to identify factors related to indications of fine needle aspiration (FNA), type of surgery, and central lymph node dissection (CLND)...
November 2017: Medicine (Baltimore)
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