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Thyroid FNA

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https://www.readbyqxmd.com/read/29457291/does-sedation-offer-better-outcomes-than-local-anaesthesia-for-thyroid-fna-in-adult-patients
#1
R M Kholmatov, H S Khadra, F Murad, T M Ahmed, A B Sholl, E Kandil
OBJECTIVE: To examine the potential benefits of sedation in adults undergoing fine needle aspiration (FNA) of thyroid nodules. METHODS: This retrospective study compared the outcomes of sedated and non-sedated FNA patients. RESULTS: A total of 860 patients underwent 1698 FNAs of thyroid nodules. The mean patient age was 52.4±14.4 years, and 80.2% of patients were women. The non-sedated group consisted of 782 patients with 1543 (93.5%) FNA procedures...
February 18, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29446257/utilization-of-direct-smears-of-thyroid-fine-needle-aspirates-for-ancillary-molecular-testing-a-comparison-of-two-proprietary-testing-platforms
#2
Kristen L Partyka, Melissa L Randolph, Karen A Lawrence, Harvey Cramer, Howard H Wu
BACKGROUND: Ancillary molecular testing has been recommended for thyroid fine-needle aspirates (FNA) with indeterminate cytologic diagnoses. Rosetta Genomics and Interpace Diagnostics have developed assays that can utilize direct smears as the testing substrate. METHODS: A retrospective study of indeterminate thyroid FNAs with known histologic follow-up was performed. One Diff-Quik-stained smear and one Papanicolaou-stained smear with similar cellularity (at least 60-100 lesional cells) from each case were sent to Rosetta and Interpace, respectively, for analysis...
February 15, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29431057/evolution-in-the-management-of-thyroid-cancer-an-observational-study-in-two-referral-centres-in-belgium
#3
Bernard Peene, Annick Van den Bruel, Carolien Moyson, Brigitte Decallonne
Objective Thyroid cancer incidence is increasing. The rise is most pronounced for microcancers (≤10 mm, T1a). In 2006, landmark European and American guidelines for the management of thyroid cancer were published. We studied thyroid cancer characteristics and initial management before and after 2006. Methods We conducted a retrospective observational study of non-medullary thyroid cancer patients that underwent thyroidectomy in two Belgian referral centres comparing pre-, per- and post-operative management in a cohort before and after 2006...
February 12, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29429327/preoperative-cytologic-diagnosis-of-warthin-like-tumor-variant-of-papillary-thyroid-carcinoma
#4
Jisup Kim, Beom Jin Lim, Soon Won Hong, Ju Yeon Pyo
Background: Warthin-like variant of papillary thyroid carcinoma (WLV-PTC) is a relatively rare variant of papillary thyroid carcinoma with favorable prognosis. However, preoperative diagnosis using fine-needle aspiration (FNA) specimens is challenging especially with lymphocytic thyroiditis characterized by Hürthle cells and lymphocytic background. To determine a helpful cytological differential point, we compared WLV-PTC FNA findings with conventional papillary thyroid carcinoma with lymphocytic thyroiditis (PTC-LT) and conventional papillary thyroid carcinoma without lymphocytic thyroiditis (PTC) regarding infiltrating inflammatory cells and their distribution...
February 12, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29428046/the-bethesda-classification-for-thyroid-fine-needle-aspiration-a-predictor-or-an-alarmist
#5
John D Galbraith, Noah Swann, Brian Cox, Nobel LeTendre, James Recabaren
Thyroid malignancies comprise only 2 per cent of all cancers. Yet the incidence of thyroid cancers has been increasing faster than other malignancies, likely due to increased screening and surveillance of thyroid nodules. The Bethesda system represents the preferred method of evaluating thyroid nodules for malignancy using fine needle aspiration (FNA). Many thyroidectomies are performed for small, asymptomatic nodules found on ultrasound. These small papillary cancers (<0.5 cm) are termed microcarcinomas and represent a more indolent natural history causing some to name them "occult papillary tumors...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29427991/reliability-of-core-needle-biopsy-as-a-second-line-procedure-in-thyroid-nodules-with-an-indeterminate-fine-needle-aspiration-report-a-systematic-review-and-meta-analysis
#6
Pierpaolo Trimboli, Luca Giovanella
Purpose: This study was undertaken to summarize the published data and to provide more robust estimates regarding the issue of core needle biopsy (CNB) for discriminating thyroid nodules with indeterminate fine-needle aspiration (FNA) results. Methods: The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The sources comprised studies published through November 2017. Original articles that investigated CNB in indeterminate thyroid lesions were searched...
January 2, 2018: Ultrasonography
https://www.readbyqxmd.com/read/29424960/the-impact-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-on-the-rate-of-malignancy-for-atypia-of-undetermined-significance-subcategories
#7
Jen-Fan Hang, William H Westra, Amy G Zhou, David S Cooper, Syed Z Ali
BACKGROUND: The recent revision in terminology, with noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) replacing noninvasive follicular variant of papillary thyroid carcinoma, has reclassified the clinically indolent tumor as nonmalignant. The objective of this study was to evaluate the impact of this change on the rate of malignancy (ROM) for subcategories of an atypia of undetermined significance (AUS) diagnosis on fine-needle aspiration (FNA) cytology...
February 9, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29424371/incidental-thyroid-carcinoma-in-patients-with-tir1-tir2-and-tir3-fna
#8
Angela Pezzolla, Serafina Lattarulo, Graziana Barile, Daniele Paradies, Giuseppe Pentassuglia, Francesco Prete, Rinaldo Marzaioli
AIM: The aim of our study was to evaluate the presence of incidental differentiated thyroid carcinomas, at final histological examination, in patients undergoing thyroidectomy or lobectomy for presumed benign pathology or in those with cytological diagnosis of indeterminate nodules (TIR3). MATERIAL OF STUDY: 457 patients who underwent surgery for benign disease and 179 patients with indeterminate FNA were included in our study. RESULTS: 77 out of 457 patients had the diagnosis of differentiated thyroid carcinoma...
February 9, 2018: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29408952/predictive-value-of-malignancy-of-thyroid-nodule-ultrasound-classification-systems-a-prospective-study
#9
Agnese Persichetti, Enrico Di Stasio, Rinaldo Guglielmi, Giancarlo Bizzarri, Silvia Taccogna, Irene Misischi, Filomena Graziano, Lucilla Petrucci, Antonio Bianchini, Enrico Papini
Background: British Thyroid Association (BTA), American Thyroid Association (ATA) and American Association of Clinical Endocrinologists (AACE/ACE/AME) recommend for thyroid nodules an ultrasound (US)-based stratification of risk of malignancy. Aim of our study was to assess the diagnostic accuracy of US classification systems and their reliability for indication to fine-needle aspiration (FNA). Methods: Prospective study on 987 thyroid nodules consecutively referred for FNA...
February 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29403170/comparative-assessment-of-conventional-papanicolaou-and-modified-ultrafast-papanicolaou-stains-in-fine-needle-aspiration-samples-and-body-fluids
#10
P Arul, S Eniya, Magesh Pushparaj, Suresh Masilamani, P Kanmani, C Lingasamy
Background: Conventional Papanicolaou (Pap) stain has undergone many modifications; of these, ultrafast Pap stain is the most popular as it shortens the turnaround time of reporting. Application of modified ultrafast Pap (MUFP) stain in the evaluation of fine needle aspiration (FNA) samples and body fluids are scanty. Aim: To evaluate the utility of MUFP stain in various FNA samples and body fluids and compare the findings with those of conventional Pap stain. Materials and Methods: In this cross-sectional study, two wet-fixed and two airdried smears from each sample [301 samples (255 FNA samples and 46 body fluids)] were prepared and stained by the conventional Pap and MUFP stains, respectively...
January 2018: Journal of Cytology
https://www.readbyqxmd.com/read/29396809/molecular-testing-of-nodules-with-a-suspicious-or-malignant-cytologic-diagnosis-in-the-setting-of-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp
#11
Kyle C Strickland, Markus Eszlinger, Ralf Paschke, Trevor E Angell, Erik K Alexander, Ellen Marqusee, Matthew A Nehs, Vickie Y Jo, Alarice Lowe, Marina Vivero, Monica Hollowell, Xiaohua Qian, Tad Wieczorek, Christopher A French, Lisa A Teot, Edmund S Cibas, Neal I Lindeman, Jeffrey F Krane, Justine A Barletta
Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is an indolent thyroid tumor characterized by frequent RAS mutations and an absence of the BRAF V600E mutation commonly seen in classical papillary thyroid carcinoma (cPTC). The ability to differentiate potential NIFTP/follicular variant of papillary thyroid carcinoma (FVPTC) from cPTC at the time of fine-needle aspiration (FNA) can facilitate conservative management of NIFTP. The aim of the current study was to investigate how molecular testing may add to cytologic assessment in the pre-operative differentiation of potential NIFTP/FVPTC and cPTC...
February 2, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29393083/factors-that-influence-sample-adequacy-in-liquid-based-cytology-after-ultrasonography-guided-fine-needle-aspiration-of-thyroid-nodules-a-single-center-study
#12
Yoo Jin Lee, Dong Wook Kim, Soo Jin Jung, Hye Jin Baek
OBJECTIVE: The factors that influence the acquisition of adequate samples during liquid-based cytology (LBC) remain unclear. This study aimed to identify factors that affect cytological adequacy in LBC after ultrasonography (US)-guided fine-needle aspiration (US-FNA) of thyroid nodules. STUDY DESIGN: From January 2017 to May 2017, a single radiologist performed US-FNA to diagnose 112 thyroid nodules in 112 consecutive patients. Based on US findings after US-FNA, the size, location, position, composition, calcification, and vascularity of each nodule, as well as the US-based diagnosis, were investigated by the same radiologist...
January 23, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29388401/comparison-of-immunohistochemistry-and-direct-sanger-sequencing-for-detection-of-the-braf-v600e-mutation-in-thyroid-neoplasm
#13
Hye Seon Oh, Hyemi Kwon, Suyeon Park, Mijin Kim, Min Ji Jeon, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Jene Choi, Won Gu Kim, Dong Eun Song
BACKGROUND: The BRAF(V600E) mutation is the most common genetic alteration identified in papillary thyroid carcinoma (PTC). Because of its costs effectiveness and sensitivity, direct Sanger sequencing has several limitations. The aim of this study was to evaluate the efficiency of immunohistochemistry (IHC) as an alternative method to detect the BRAF(V600E) mutation in preoperative and postoperative tissue samples. METHODS: We evaluated 71 patients who underwent thyroid surgery with the result of direct sequencing of the BRAF(V600E) mutation...
January 30, 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29364576/simultaneous-detection-of-single-nucleotide-variant-deletion-insertion-and-fusion-in-lung-and-thyroid-carcinoma-using-cytology-specimen-and-an-rna-based-next-generation-sequencing-assay
#14
Natalya V Guseva, Omar Jaber, Aaron A Stence, Krishnaveni Sompallae, Amani Bashir, Ramakrishna Sompallae, Aaron D Bossler, Chris S Jensen, Deqin Ma
BACKGROUND: Molecular testing for epidermal growth factor receptor (EGFR) mutation and anaplastic lymphoma kinase (ALK) and ROS proto-oncogene 1, receptor tyrosine kinase (ROS1) fusion is routinely performed in patients with stage IV lung adenocarcinoma to assess their eligibility for targeted therapy. Fine-needle aspiration (FNA)-derived material frequently is the only pathologic material available. The identification of genomic aberrations in thyroid nodules from FNA smears may help stratify cancer risk and spare patients from a second surgery...
January 24, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29356393/improvement-of-diagnostic-performance-of-pathologists-by-reducing-the-number-of-pathologists-responsible-for-thyroid-fine-needle-aspiration-cytology-an-institutional-experience
#15
Jae Yeon Seok, Jungsuk An, Hyun Yee Cho
BACKGROUND: Various efforts have been made to improve the diagnostic accuracy of thyroid fine needle aspiration (FNA) cytology. We changed the diagnostic system by reducing the number of pathologists responsible for the thyroid FNA cytology in the routine work, and analyzed the effect on the pathologist's diagnostic performance. METHODS: Since March 1, 2015, 3 pathologists have been responsible for diagnostic thyroid FNA, previously undertaken by 9 equally. We compared the prechange period (three months, 319 nodules) and the postchange period (12 months, 1194 nodules)...
January 22, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29354013/ultrasonographic-interval-changes-in-solid-thyroid-nodules-after-ultrasonography-guided-fine-needle-aspiration
#16
Ik Jung Hwang, Dong Wook Kim, Yoo Jin Lee, Hye Jung Choo, Soo Jin Jung, Hye Jin Baek
Objective: None of the previous studies have investigated the interval change in ultrasonography (US) features of solid thyroid nodules (STNs) after US-guided fine-needle aspiration (US-FNA). This study aimed to assess the prevalence and characteristics of US interval changes in STNs after US-FNA. Materials and Methods: This study included 257 STNs in 257 patients in whom thyroid US and initial US-FNA had been performed by two radiologists from January 2015 to June 2015...
January 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/29345728/analytical-performance-of-the-thyroseq-v3-genomic-classifier-for-cancer-diagnosis-in-thyroid-nodules
#17
Marina N Nikiforova, Stephanie Mercurio, Abigail I Wald, Michelle Barbi de Moura, Keith Callenberg, Lucas Santana-Santos, William E Gooding, Linwah Yip, Robert L Ferris, Yuri E Nikiforov
BACKGROUND: Molecular tests have clinical utility for thyroid nodules with indeterminate fine-needle aspiration (FNA) cytology, although their performance requires further improvement. This study evaluated the analytical performance of the newly created ThyroSeq v3 test. METHODS: ThyroSeq v3 is a DNA- and RNA-based next-generation sequencing assay that analyzes 112 genes for a variety of genetic alterations, including point mutations, insertions/deletions, gene fusions, copy number alterations, and abnormal gene expression, and it uses a genomic classifier (GC) to separate malignant lesions from benign lesions...
January 18, 2018: Cancer
https://www.readbyqxmd.com/read/29338082/racial-ethnic-differences-in-thyroid-cancer-incidence-in-the-united-states-2007-2014
#18
Kristin S Weeks, Amanda R Kahl, Charles F Lynch, Mary E Charlton
BACKGROUND: Small tumor diagnostic tools including ultrasound-guided fine needle aspiration (FNA) and computed tomography (CT) could be causing rising and racially/ethnically different thyroid cancer incidence rates due to variable overdiagnosis of indolent tumors. Papillary tumors and <40 mm tumors are most likely to be overdiagnosed as indolent tumors by FNA and CT. METHODS: Age-adjusted incidence rates (AAIRs) for the years 2007-2014 were calculated for race/ethnicity (white, Hispanic, Asian, African American, Native American) by patient/tumor characteristics for microscopically confirmed malignant thyroid cancer cases in the Surveillance, Epidemiology, and End Results Program 18 database (SEER 18; N = 93,607)...
January 16, 2018: Cancer
https://www.readbyqxmd.com/read/29317955/pattern-of-thyroid-lesions-in-western-region-of-saudi-arabia-a-retrospective-analysis-and-literature-review
#19
Muhammad I Saeed, Amal Ali Hassan, Muhammad Ejaz Butt, Khalid Ali Baniyaseen, Muhammad I Siddiqui, Neda M Bogari, Faisal A Al-Allaf, Mohiuddin M Taher
Background: Ultrasonography (US) is being recognized as a traditional way of the diagnosis of various thyroid disorders, and this will help in detecting the thyroid tumors in early stage. Thyroid nodules are common and usually benign; steps to diagnose malignancy should include a careful clinical evaluation, laboratory tests, a thyroid US exam and a fine-needle aspiration (FNA) biopsy. Methods: A total of 173 registered cases were used for analysis in this study...
February 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29317181/extramedullary-hematopoiesis-involving-the-thyroid-a-rare-cytologic-finding-in-otherwise-healthy-patients-and-review-of-literature
#20
I-Shiow Jan, Ming-Hsiang Weng, Chih-Yuan Wang, Tien-Chun Chang, Shyang-Rong Shih
BACKGROUND/PURPOSE: The thyroid gland is an uncommon site for the presence of extramedullary hematopoiesis (EMH). We report the cases of four Taiwanese women with hematopoietic elements on the smears of thyroid fine needle aspiration (FNA) samples and compare the findings with those of previously reported cases. METHODS: We retrieved the data of cases in which thyroid FNA performed between January 2000 and December 2016. The clinical manifestations, laboratory data, and image findings of cases with thyroid EMH were reported...
January 6, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
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