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Thyroid FNA

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https://www.readbyqxmd.com/read/27900100/avoidance-of-unnecessary-fine-needle-aspiration-with-the-use-of-the-thyroid-imaging-reporting-data-system-classification-and-strain-elastography-based-on-the-bethesda-system-for-reporting-thyroid-cytopathology
#1
Murat Erkan, Sule Canberk, Gamze Z Kilicoglu, Mine Onenerk, Atay Uludokumaci, Pembegul Gunes, Tugba Atasoy
Thyroid fine-needle aspiration (FNA) biopsy has been widely accepted as an accurate and cost-effective tool in the management of thyroid nodules. To avoid unnecessary FNAs and provide appropriate management, patient evaluation should be based on a multidisciplinary approach. For this purpose, the Thyroid Imaging Reporting and Data System (TI-RADS) and strain elastography (SE) were proposed as tools for the risk assessment of malignancy in thyroid nodules. The aim of the present study was to analyze the utility of TI-RADS system and SE, along with FNA, and prospectively evaluate 369 consecutive patients referred for FNA of a thyroid nodule...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27891005/endobronchial-ultrasound-guided-transbronchial-needle-aspiration-of-thyroid-report-of-two-cases-and-systematic-review-of-literature
#2
Karan Madan, Saurabh Mittal, Vijay Hadda, Deepali Jain, Anant Mohan, Randeep Guleria
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive and safe technique for a sampling of mediastinal lesions. Indications for EBUS-TBNA have gradually expanded since its introduction. The usual approach to cytological sampling of the thyroid gland is percutaneous ultrasound-guided fine needle aspiration (US-FNA) performed under local anesthesia. US-FNA may be risky or not feasible in intrathoracic/substernal thyroid location. Feasibility of aspirating thyroid lesions with EBUS-TBNA has been occasionally reported...
November 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27871285/next-generation-sequencing-in-thyroid-cancer
#3
REVIEW
Yoon Jin Cha, Ja Seung Koo
Next-generation sequencing (NGS) in thyroid cancer allows for simultaneous high-throughput sequencing analysis of variable genetic alterations and provides a comprehensive understanding of tumor biology. In thyroid cancer, NGS offers diagnostic improvements for fine needle aspiration (FNA) cytology of thyroid with indeterminate features. It also contributes to patient management, providing risk stratification of patients based on the risk of malignancy. Furthermore, NGS has been adopted in cancer research. It is used in molecular tumor classification, and molecular prediction of recurrence and metastasis in papillary thyroid carcinoma...
November 21, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27852075/thyroid-atypia-follicular-lesion-of-undetermined-significance-attitudes-towards-the-diagnosis-of-bethesda-system-iii-nodules
#4
Lourdes Estrada Muñoz, Cristina Díaz Del Arco, Luis Ortega Medina, M Jesús Fernández Aceñero
OBJECTIVES: To review our institutional experience and to analyze the clinical decisions made after a cytological diagnosis of atypia of undetermined significance or follicular lesion of undetermined significance (AUS/FLUS). STUDY DESIGN: This is a retrospective review of all thyroid fine-needle aspiration (FNA) cytologies performed in the Hospital Clínico San Carlos (Madrid) between 2010 and 2014. RESULTS: One hundred thirty thyroid FNA were categorized as AUS/FLUS (5%)...
November 17, 2016: Acta Cytologica
https://www.readbyqxmd.com/read/27835583/non-invasive-diagnosis-of-papillary-thyroid-microcarcinoma-a-nmr-based-metabolomics-approach
#5
Jinghui Lu, Sanyuan Hu, Paolo Miccoli, Qingdong Zeng, Shaozhuang Liu, Lin Ran, Chunxiao Hu
Papillary thyroid microcarcinoma (PTMC) is a subtype of papillary thyroid carcinoma (PTC). Because its diameter is less than 10 mm, diagnosing it accurately is difficult with traditional methods such as image examinations and FNA (Fine Needle Aspiration). Investigating the metabolic changes induced by PTMC may enhance the understanding of its pathogenesis and provide important information for a new diagnosis method and treatment plan. In this study, high resolution magic angle spin (HRMAS) spectroscopy and 1H-nuclear magnetic resonance (1H-NMR) spectroscopy were used to screen metabolic changes in thyroid tissues and plasma from PTMC patients respectively...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27818286/inverse-expression-of-caveolin-1-and-egfr-in-thyroid-cancer-patients
#6
Jelena Janković, Svetislav Tatić, Vesna Božić, Vladan Živaljević, Dubravka Cvejić, Svetlana Paskaš
Cytological analysis of fine-needle aspiration (FNA) is the first step in evaluation of patients with nodular thyroid disease with the primary goal to exclude thyroid malignancy. Its improvement by combining cytology with molecular markers is still a matter of investigation. In this study two molecular markers were used: caveolin-1 and EGFR, along with the well-established genetic marker - BRAF V600E mutation. We set out to determine the expression signatures of EGFR and caveolin-1, in patients with thyroid malignancy, as well as to determine their possible association with disease severity...
November 3, 2016: Human Pathology
https://www.readbyqxmd.com/read/27808486/novel-acquisitions-in-the-diagnosis-of-medullary-thyroid-carcinoma
#7
Pierpaolo Trimboli, Anna Crescenzi, Enrico Saggiorato, Giorgio Treglia, Luca Giovanella
BACKGROUND: The correct identification of medullary thyroid carcinoma (MTC) has been a challenge since its first description. In the last years some advances in this context have been achieved. Here we aimed to review and discuss published data on the more recent acquisition in the diagnosis of MTC. METHODS: A literature search of the medical databases was conducted by searching papers reporting tool for diagnosis of MTC published in the last years. The search was updated until July 2016...
November 3, 2016: Minerva Endocrinologica
https://www.readbyqxmd.com/read/27805426/the-metabolomics-and-lipidomics-window-into-thyroid-cancer-research
#8
R Farrokhi Yekta, M Rezaie Tavirani, A Arefi Oskouie, M R Mohajeri-Tehrani, A R Soroush
CONTEXT: Thyroid carcinoma is the most common endocrine system malignancy with a fast rising incidence in the last decade for unknown reasons. Fine needle aspiration (FNA) biopsy, the gold standard in thyroid cancer (TC) screening has still its own challenges and in some cases needs a proceeding surgery. OBJECTIVE: This review highlights the role of the two most recent "omics" approaches, "metabolomics" and "lipidomics", in the field of TC research. METHODS: All the previous studies have been extracted from the literature and major concepts were detailed in the field of TC metabolomics and lipidomics...
November 15, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27802177/measurement-of-thyroglobulin-calcitonin-and-pth-in-fna-washout-fluids
#9
Pierpaolo Trimboli, Federica D'Aurizio, Renato Tozzoli, Luca Giovanella
Different imaging tools, circulating endocrine markers, and fine-needle aspiration (FNA) cytology are of great importance in the diagnosis and follow-up of different thyroid and parathyroid diseases. Sometimes, however, they are conflicting or inconclusive: interestingly, measuring endocrine markers (i.e. thyroglobulin, calcitonin, parathyroid hormone) in fluids from FNA proved to be a very useful complementary diagnostic tool in such cases. The determination of endocrine markers in fluids other than serum/plasma has been developed in the last years...
October 29, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27798083/multicentre-validation-of-a-microrna-based-assay-for-diagnosing-indeterminate-thyroid-nodules-utilising-fine-needle-aspirate-smears
#10
Gila Lithwick-Yanai, Nir Dromi, Alexander Shtabsky, Sara Morgenstern, Yulia Strenov, Meora Feinmesser, Vladimir Kravtsov, Marino E Leon, Marián Hajdúch, Syed Z Ali, Christopher J VandenBussche, Xinmin Zhang, Leonor Leider-Trejo, Asia Zubkov, Sergey Vorobyov, Michal Kushnir, Yaron Goren, Sarit Tabak, Etti Kadosh, Hila Benjamin, Temima Schnitzer-Perlman, Hagai Marmor, Maria Motin, Danit Lebanony, Sharon Kredo-Russo, Heather Mitchell, Melissa Noller, Alexis Smith, Olivia Dattner, Karin Ashkenazi, Mats Sanden, Kenneth A Berlin, Dganit Bar, Eti Meiri
AIMS: The distinction between benign and malignant thyroid nodules has important therapeutic implications. Our objective was to develop an assay that could classify indeterminate thyroid nodules as benign or suspicious, using routinely prepared fine needle aspirate (FNA) cytology smears. METHODS: A training set of 375 FNA smears was used to develop the microRNA-based assay, which was validated using a blinded, multicentre, retrospective cohort of 201 smears. Final diagnosis of the validation samples was determined based on corresponding surgical specimens, reviewed by the contributing institute pathologist and two independent pathologists...
October 26, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27770513/cytology-diagnosis-of-metastatic-clear-cell-renal-cell-carcinoma-synchronous-to-pancreas-and-metachronous-to-thyroid-and-contralateral-adrenal-report-of-a-case-and-literature-review
#11
Aqiba Bokhari, Patricia G Tiscornia-Wasserman
Renal cell carcinoma metastases to pancreas, thyroid, and contralateral adrenal gland are decidedly uncommon. Clear cell renal cell carcinoma (CCRCC) is the most frequent subtype. Cytology diagnosis may be challenging. A 74-year-old male with remote history of vocal cord malignancy and hypertension presented with abdominal pain. Computed tomography (CT) revealed 8.4 cm left renal mass highly suspicious for renal cell carcinoma, a 1.8 cm mass within vessels near left adrenal and a 2.5 cm mass in pancreatic tail...
October 22, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27764825/the-bethesda-system-for-reporting-thyroid-cytopathology-proposed-modifications-and-updates-for-the-second-edition-from-an-international-panel
#12
Marc Pusztaszeri, Esther Diana Rossi, Manon Auger, Zubair Baloch, Justin Bishop, Massimo Bongiovanni, Ashish Chandra, Beatrix Cochand-Priollet, Guido Fadda, Mitsuyoshi Hirokawa, SoonWon Hong, Kennichi Kakudo, Jeffrey F Krane, Ritu Nayar, Sareh Parangi, Fernando Schmitt, William C Faquin
The Bethesda System for Reporting Thyroid Cytology (TBSRTC) was proposed in 2007 at the National Cancer Institute Thyroid Fine Needle Aspiration State of the Art and Science Conference held in Bethesda, Maryland. The aim was to address the inconsistent and sometimes confusing reporting terminologies used for thyroid FNA throughout the world. The TBSRTC consists of 6 diagnostic categories, each associated with an implied risk of malignancy that translates directly into a clinical management algorithm. Since the publication of the TBSRTC cytology Atlas in January 2010, considerable experience has been gained regarding its application in cytology practice, clinical impact, and limitations...
2016: Acta Cytologica
https://www.readbyqxmd.com/read/27761926/preoperative-differentiation-between-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-and-non-niftp
#13
Soo Yeon Hahn, Jung Hee Shin, Hyun Kyung Lim, So Lyung Jung, Young Lyun Oh, In Ho Choi, Chan Kwon Jung
BACKGROUND: A recent concept was proposed that the non-invasive encapsulated follicular variant of papillary thyroid carcinoma (EFVPTC) reclassified as "non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is benign. Our aim was to identify the differences between NIFTP and non-NIFTP preoperatively. METHODS: This retrospective study included a total of 208 patients with 208 FVPTCs that were surgically confirmed at 3 university hospitals from 2008 through 2014...
October 19, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/27761148/oncocytic-variant-of-poorly-differentiated-thyroid-carcinoma-is-diagnosis-possible-by-fine-needle-aspiration
#14
Mine Onenerk, Sule Canberk, Pembegul Gunes, Murat Erkan, Gamze Z Kilicoglu
Poorly differentiated thyroid carcinoma (PDTC) is a very rare entity, and the diagnosis can be made on histopathology specimens. However, recognition of characteristic features of PDTC is significant on fine-needle aspirations (FNAs) to differentiate this entity from well-differentiated and anaplastic thyroid carcinomas. Here, we present an FNA case concordant with "oncocytic variant of PDTC" and discuss whether definitive diagnosis can be given on FNAs to assess the prognosis in clinically inoperable patients...
2016: CytoJournal
https://www.readbyqxmd.com/read/27760899/small-nonfunctional-parathyroid-cysts-single-institution-experience
#15
Ljubica Fustar Preradovic, Davorin Danic, Radan Dzodic
Parathyroid cysts (PCs) account for less than 1% of all parathyroid lesions and are most commonly located along thyroid lobes, rarely at ectopic sites. PCs are important because they can pose a differential diagnostic challenge against other cystic formations of the neck. PCs can be functional (elevated serum parathyroid hormone level) and nonfunctional. Four cases of nonfunctional PCs are presented. All four female patients underwent physical examination and ultrasonography of the neck with ultrasound-guided fine-needle aspiration biopsy (UG-FNA)...
October 19, 2016: Endocrine Journal
https://www.readbyqxmd.com/read/27756982/fine-needle-aspiration-study-of-cystic-papillary-thyroid-carcinoma-rare-cytological-findings
#16
Maral Mokhtari, Perikala Vijayananda Kumar, Kamran Hayati
BACKGROUND: Cystic papillary thyroid carcinoma (CPTC) is a variant of papillary carcinoma that has many mimickers in cytological grounds. AIM: To study the cytomorphologic features of CPTC and compare them to those of other cystic thyroid lesions using fine-needle aspiration cytology (FNAC). We also aimed to identify the cytomorphologic features that distinguish CPTC from other cystic thyroid lesions. MATERIALS AND METHODS: Seventy-three cases of CPTC were included in the study...
July 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27742787/thyroid-cancer-risk-stratified-management-and-individualized-therapy
#17
Friedhelm Raue, Karin Frank-Raue
Thyroid cancer is the most common endocrine malignancy. Differentiated thyroid cancer (DTC) with the two subtypes, papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC), is the most frequent subtype of thyroid cancer; more rare subtypes are medullary thyroid cancer (MTC) and anaplastic thyroid cancer (ATC). The incidence of DTC has increased rapidly in recent years due to the more frequent use of imaging methods such as ultrasound of the neck and fine-needle aspiration (FNA) of thyroid nodules...
October 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27738849/thyroglobulin-measurement-in-fine-needle-aspiration-improves-the-diagnosis-of-cervical-lymph-node-metastases-in-papillary-thyroid-carcinoma
#18
Zahraa Al-Hilli, Veljko Strajina, Travis J McKenzie, Geoffrey B Thompson, David R Farley, M Regina Castro, Alicia Algeciras-Schimnich, Melanie L Richards
BACKGROUND: Papillary thyroid carcinoma (PTC) is frequently associated with cervical lymph node metastases. Guidelines recommend performing ultrasound-guided fine-needle aspiration cytology (FNAC) for suspicious nodes to guide management. No specific recommendations are available for the use of FNA thyroglobulin assay (FNA-Tg). This study investigated the diagnostic value of performing FNAC and FNA-Tg. METHODS: Patient demographics, preoperative investigations, surgery, and lymph node pathology were collected for patients with PTC who underwent lateral neck lymphadenectomy and central compartment reexploration from January 2000 to July 2015...
October 13, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27717198/young-investigator-challenge-can-the-ion-ampliseq-cancer-hotspot-panel-v2-be-used-for-next-generation-sequencing-of-thyroid-fna-samples
#19
Claudio Bellevicine, Roberta Sgariglia, Umberto Malapelle, Elena Vigliar, Mariantonia Nacchio, Giuseppe Ciancia, Markus Eszlinger, Ralf Paschke, Giancarlo Troncone
BACKGROUND: Fine-needle aspiration (FNA) cytology is accurate and cost-effective in the evaluation of thyroid nodules. Molecular techniques may contribute to risk stratification in indeterminate cases. Although next-generation sequencing (NGS) is a promising technique for the molecular testing of thyroid FNA specimens, thyroid-specific cancer gene panels are not commercially available. Conversely, the Ion AmpliSeq Cancer Hotspot Panel v2 (CHPv2), which includes the genes most frequently mutated in thyroid neoplasms, is commercially available and may represent an alternative to thyroid-specific panels...
November 2016: Cancer
https://www.readbyqxmd.com/read/27704660/efficacy-of-ultrasound-guided-fine-needle-aspiration-performed-by-surgeons-newly-trained-in-thyroid-ultrasound
#20
Agnaldo J Graciano, Carlos A Fischer, Carlos T Chone, Giuliano S Bublitz, Marina Sonagli, Cezar A Rodrigues Filho
BACKGROUND: There are a growing number of thyroid ultrasound courses to train endocrinologists, pathologists, and surgeons to perform ultrasound-guided fine-needle aspiration (FNA). However, there are limited data to support the efficacy of ultrasound-guided FNA performed by nonradiologists. METHODS: We compared the efficacy of ultrasound-guided FNA performed by surgeons newly trained in thyroid ultrasound with that of the same technique performed by 1 experienced radiologist...
October 5, 2016: Head & Neck
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