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Thyroid cytopathology

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https://www.readbyqxmd.com/read/28734572/experience-of-the-implementation-of-rapid-on-site-evaluation-in-ultrasound-guided-fine-needle-aspiration-biopsy-of-thyroid-nodules
#1
Flor Marina Medina Chamorro, José Abella Calle, Juliana Escobar Stein, Lina Merchancano, Andrés Mauricio Mendoza Briñez, Andrés Arturo Pulido Wilches
OBJECTIVE: To evaluate the effect of the implementation of the rapid on-site evaluation (ROSE) technique in ultrasound-guided fine-needle aspiration biopsy of thyroid nodules. MATERIALS AND METHODS: We conducted an observational and retrospective study approved by the Institutional Ethics Committee as an investigation without risk. Between January 2012 and December 2015, 892 ultrasound-guided fine-needle aspiration biopsy procedures were performed under ultrasound guidance...
June 27, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28701827/malignancy-rate-in-thyroid-nodules-categorized-as-atypia-of-undetermined-significance-or-follicular-lesion-of-undetermined-significance-an-institutional-experience
#2
Smita Chandra, Harish Chandra, Sampan S Bisht
INTRODUCTION: Atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS) of Bethesda system for reporting thyroid cytopathology has emerged as most controversial category due to its heterogeneity and inconsistent usage. Initially associated risk of malignancy was estimated to be about 5-15%, but eventually different results have been obtained across institutions due to variable follow-ups and interpretation. The present study was conducted to evaluate the rate of malignancy along with appropriate management in this category...
July 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28701706/intraoperative-frozen-section-can-be-reduced-in-thyroid-nodules-classified-as-bethesda-categories-v-and-vi
#3
Jing Huang, Jieli Luo, Jianshe Chen, Yang Sun, Chao Zhang, Kanlun Xu, Qin Ye, Pintong Huang
Intraoperative frozen section (FS) can be reduced during thyroid lobectomy according to the results of fine needle aspiration (FNA). We evaluated the role of intraoperative FS in thyroid nodules with different diagnostic categories of the Bethesda System for Reporting Thyroid Cytopathology by FNA. This retrospective study included 1,235 nodules collected via thyroidectomy with both preoperative FNA and intraoperative FS at the Second Affiliated Hospital of Zhejiang University School of Medicine, from January 2011 to January 2014...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699990/likelihood-of-malignancy-in-thyroid-nodules-according-to-a-proposed-thyroid-imaging-reporting-and-data-system-ti-rads-classification-merging-suspicious-and-benign-ultrasound-features
#4
Ricardo Luiz Costantin Delfim, Leticia Carrasco Garcez da Veiga, Ana Paula Aguiar Vidal, Flávia Paiva Proença Lobo Lopes, Mário Vaisman, Patrícia de Fatima Dos Santos Teixeira
Objective: The aim of this study was to describe the ultrasound features of benign and malignant thyroid nodules and evaluate the likelihood of malignancy associated with each feature according to the Bethesda System for Reporting Thyroid Cytopathology and histopathology. With this analysis, we propose a new TI-RADS classification system. Materials and methods: The likelihood of malignancy from ultrasound features were assessed in 1413 thyroid nodules according to the Bethesda System for Reporting Thyroid Cytopathology and histopathological findings...
May 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28696007/comparison-of-conventional-cytology-and-surepath-in-split-thyroid-fine-needle-aspiration-materials
#5
D Sahin, D Yilmazbayhan, P Firat, U P Hacisalihoglu, S H Kirimlioglu, E Celenk, R Arslan
OBJECTIVE: The aim of the present study was to compare the cytomorphological features and cytopathological diagnoses in thyroid aspiration materials prepared by SurePath® (SP) and conventional cytology (CC). MATERIALS AND METHODS: Fine needle aspiration (FNA) materials from 180 thyroid nodules were divided into two groups to prepare three conventional smears and one SP slide. Twenty-nine cytomorphological features of thyroid lesions were compared in the CC and SP slides...
July 11, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28689321/underestimated-risk-of-cancer-in-solitary-thyroid-nodules-%C3%A2-3%C3%A2-cm-reported-as-benign
#6
Sohail Bakkar, Anello Marcello Poma, Caterina Corsini, Mario Miccoli, Carlo Enrico Ambrosini, Paolo Miccoli
BACKGROUND: The study aims to assess the risk of cancer in solitary thyroid nodules ≥30 mm in size reported as Bethesda II, and its implications. METHOD: The clinical records of 202 patients, who underwent thyroid lobectomy for solitary nodules measuring ≥30 mm, reported as Bethesda II on preoperative FNAC between Jan 2015 and Apr 2016 were reviewed. Data collected included nodule size and consistency, and final histopathology results. The risk of cancer and the recommended management according to ATA guidelines were the outcomes of interest...
July 8, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28657511/validation-of-american-thyroid-association-ultrasound-risk-assessment-of-thyroid-nodules-selected-for-ultrasound-fine-needle-aspiration
#7
Alice L Tang, Mercedes Falciglia, Huaitao Yang, Jonathan R Mark, David L Steward
OBJECTIVE: The aim of this study was to validate the American Thyroid Association (ATA) sonographic risk assessment of thyroid nodules. METHODS: The ATA sonographic risk assessment was prospectively applied to 206 thyroid nodules selected for ultrasound-guided fine-needle aspiration (US-FNA), and analyzed with The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), as well as surgical pathology for the subset undergoing surgical excision. RESULTS: The analysis included 206 thyroid nodules averaging 2...
July 18, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28626115/reappraisal-of-cyst-fluid-only-on-thyroid-fine-needle-aspiration-cytology
#8
Nami Takada, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Akira Miyauchi
According to the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), cyst fluid only (CFO) cases are classified in the non-diagnostic category. To date, no large study focusing on CFO has been conducted. To reassess the diagnostic significance of CFO, we compared CFO nodules with non-diagnostic nodules excluding CFO (ND-other). We reviewed the conventional thyroid smears of 715 CFO and 766 ND-other nodules. We compared the timing of and findings at re-aspiration, the histology of resected specimens, and the proportion of malignant nodules between the two groups...
June 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28609825/the-use-of-the-bethesda-system-for-reporting-thyroid-cytopathology-in-korea-a-nationwide-multicenter-survey-by-the-korean-society-of-endocrine-pathologists
#9
Mi Mi Kim, Hyo Jin Park, Hye Sook Min, Hyeong Ju Kwon, Chan Kwon Jung, Seoung Wan Chae, Hyun Ju Yoo, Yoo Duk Choi, Mi Ja Lee, Jeong Ja Kwak, Dong Eun Song, Dong Hoon Kim, Hye Kyung Lee, Ji Yeon Kim, Sook Hee Hong, Jang Sihn Sohn, Hyun Seung Lee, So Yeon Park, Soon Won Hong, Mi Kyung Shin
Background: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has standardized the reporting of thyroid cytology specimens. The objective of the current study was to evaluate the nationwide usage of TBSRTC and assess the malignancy rates in each category of TBSRTC in Korea. Materials and Methods: Questionnaire surveys were used for data collection on the fine needle aspiration (FNA) of thyroid nodules at 74 institutes in 2012. The incidences and follow-up malignancy rates of each category diagnosed from January to December, 2011, in each institute were also collected and analyzed...
June 14, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28570751/preoperative-clinicopathological-characteristics-of-patients-with-solitary-encapsulated-follicular-variants-of-papillary-thyroid-carcinomas
#10
Hyemi Kwon, Min Ji Jeon, Jong Ho Yoon, Suck Joon Hong, Jeong Hyun Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Won Gu Kim, Dong Eun Song
BACKGROUND AND OBJECTIVES: Clinical outcomes in patients with the follicular variant of papillary thyroid carcinoma (FVPTC) tend to vary according to the pathological subtypes. We aimed to evaluate the clinicopathological characteristics including preoperative radiological and cytopathological diagnoses in patients with solitary encapsulated FVPTCs (EFVPTCs) to prove the preoperative assessment dilemma. METHODS: Patients with solitary FVPTCs who underwent thyroid surgery were included...
June 1, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28544576/atypical-adenoma-of-the-thyroid-diagnosed-as-anaplastic-cancer-by-cytopathology
#11
Hiromitsu Hatakeyama, Kimiko Hoshino, Kenji Mizoguchi, Takayoshi Suzuki, Kanako C Hatanaka, Yukie Yamaya, Satoshi Kano, Takatsugu Mizumachi, Akihiro Homma
Atypical adenoma of the thyroid is a rare form of tumor, and its accurate diagnosis prior to surgical resection is difficult as the histological and pathological morphologies are very similar to those of anaplastic thyroid carcinoma (ATC), and its anaplastic transformation remains to be elucidated. We reported a case of a 75-year-old female with a thyroid isthmus nodule diagnosed repeatedly by FNAC as anaplastic carcinoma. Both the first and second FNAC specimen slides showed a large number of scattered or aggregated atypical cells consisting of large, pleomorphic nuclei with irregular membranes, chromatin clumps and prominent nucleoli...
May 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28525461/18f-fdg-pet-ct-of-papillary-carcinoma-in-a-lateral-thyroglossal-duct-cyst
#12
Christos Sachpekidis, Matthias S Dettmer, Sabine Weidner, Roland Giger, Jan Wartenberg
A 69-year-old man presented with bulging of the right oropharyngeal wall, which revealed cytopathologically malignant cells. The man underwent MRI and F-FDG PET/CT, which demonstrated a cystic parapharyngeal lesion with an F-FDG-avid soft tissue component and right cervical lymph node. The patient was operated on and showed thyroid cancer in normal thyroid tissue, compatible with a papillary thyroid carcinoma in a lateral thyroglossal duct cyst and 2 ipsilateral lymph node metastases. Despite its rarity, papillary thyroid carcinoma in a thyroglossal duct cyst should be kept as one of the differential diagnoses in patients presenting with parapharyngeal cystic lesion...
August 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28511391/utility-of-modified-ultrafast-papanicolaou-stain-in-cytological-diagnosis
#13
Prachi Sinkar, Surekha Ulhas Arakeri
INTRODUCTION: Need for minimal turnaround time for assessing Fine Needle Aspiration Cytology (FNAC) has encouraged innovations in staining techniques that require lesser staining time with unequivocal cell morphology. The standard protocol for conventional Papanicolaou (PAP) stain requires about 40 minutes. To overcome this, Ultrafast Papanicolaou (UFP) stain was introduced which reduces staining time to 90 seconds and also enhances the quality. However, reagents required for this were not easily available hence, Modified Ultrafast Papanicolaou (MUFP) stain was introduced subsequently...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28506417/new-perspectives-in-the-diagnosis-of-thyroid-follicular-lesions
#14
REVIEW
Enke Baldini, Salvatore Sorrenti, Francesco Tartaglia, Antonio Catania, Andrea Palmieri, Daniele Pironi, Angelo Filippini, Salvatore Ulisse
Thyroid nodules are very common, affecting 19%-67% of the adult population. However, about 10% of them harbor a malignant lesion. Consequently, the first aim in their clinical evaluation is to exclude malignancy. Fine-needle aspiration cytology (FNAC) represents the main diagnostic tool for the evaluation of thyroid nodules. However, FNAC has a main diagnostic limit, namely cellular atypias of indeterminate significance, which require surgical excision and histological examination to differentiate benign from malignant lesions...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28488195/differences-in-clinical-features-between-subcategories-of-atypia-follicular-lesion-of-undetermined-significance
#15
Seong Dong Kim, Seung Hoon Han, Woo-Jin Jeong, Hyojin Kim, Soon Hyun Ahn
Within the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), category III (atypia or follicular lesion of undetermined significance (AUS/FLUS)) comprises specimens with heterogeneous features and the need for subcategorization has been reported. We compared the clinical features of two subgroups from within the category of AUS/FLUS to determine precise guidelines for clinicians who explain the results of fine-needle aspiration (FNA) to patients. Retrospective review was performed including data from all patients who underwent FNA with results reported as AUS/FLUS at a single tertiary hospital from January 2010 to August 2014...
May 9, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28467214/evaluation-of-the-afirma-gene-expression-classifier-in-repeat-indeterminate-thyroid-nodules
#16
Grant Harrison, Julie Ann Sosa, Xiaoyin Jiang
CONTEXT: - Molecular testing in indeterminate thyroid nodules is a rapidly evolving field with variable reported outcomes. OBJECTIVE: - To report our experience at a tertiary thyroid referral center with the Afirma Gene Expression Classifier (Veracyte, San Francisco, California) in repeat fine-needle aspirations of thyroid nodules with a previous indeterminate cytologic result. DESIGN: - Results of cytopathology and the Afirma test were collected from August 2013 to March 2015, as were diagnoses from surgical resection when performed...
May 3, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28447904/fine-needle-aspiration-versus-frozen-section-in-the-evaluation-of-malignant-thyroid-nodules-in-patients-with-the-diagnosis-of-suspicious-for-malignancy-or-malignancy-by-fine-needle-aspiration
#17
Qin Ye, Jennifer S Woo, Qunzi Zhao, Ping Wang, Pintong Huang, Lirong Chen, Xin Li, Kanlun Xu, Ying Yong, Stephanie Sung-Eun Yang, Jianyu Rao
CONTEXT: - The Bethesda System for Reporting Thyroid Cytopathology recommends against the use of intraoperative frozen section (FS) during lobectomy of a thyroid nodule with a fine-needle aspiration (FNA) diagnosis of malignant. Bethesda recommendations for FS in the FNA category of suspicious for malignancy (SFM) is less well-defined. In some institutions in China, FS examination is performed during lobectomy even for FNA-proven malignant cases. OBJECTIVE: - -To compare the efficacy of FNA versus FS in the evaluation of malignant thyroid lesions...
May 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28445876/impact-of-the-reclassification-of-the-non-invasive-follicular-variant-of-papillary-carcinoma-as-benign-on-the-malignancy-risk-of-the-bethesda-system-for-reporting-thyroid-cytopathology-a-meta-analysis-study
#18
Lester J Layfield, Zubair W Baloch, Magda Esebua, Rohini Kannuswamy, Robert L Schmidt
OBJECTIVES: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) established diagnostic categories for cytologic specimens of the thyroid. Each category was associated with an estimated risk of malignancy. Recently, the non-invasive follicular variant of papillary thyroid carcinoma has been reclassified as benign. This reclassification may alter the malignancy risk of TBSRTC diagnostic categories. STUDY DESIGN: A literature search was made for all studies investigating the effect of reclassification of some non-invasive follicular variant papillary thyroid carcinomas as benign on the malignancy risk associated with TBSRTC categories...
2017: Acta Cytologica
https://www.readbyqxmd.com/read/28439496/bethesda-system-for-reporting-thyroid-cytopathology-a-three-year-study-at-a-tertiary-care-referral-center-in-saudi-arabia
#19
Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert, Aljuboury Muna, Alkharashi Eyad, Abdullah Al Ghamdi, Khalid Al Hajeri, Mohammed A Thabet, Rim Braham
AIM: To stratify the malignancy risks in thyroid nodules in a tertiary care referral center using the Bethesda system. METHODS: From January, 2012 to December, 2014, a retrospective analysis was performed among 1188 patients (15-90 years) who had 1433 thyroid nodules and fine-needle aspiration at Prince Sultan Military Medical City, Saudi Arabia. All thyroid cyto-pathological slides and ultra sound reports were reviewed and classified according to the Bethesda System for Reporting Thyroid Cytopathology...
April 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28419762/hobnail-variant-of-papillary-thyroid-carcinoma-a-case-with-an-unusual-presentation
#20
Mohammed T Lilo, Justin A Bishop, Syed Z Ali
Variants of papillary thyroid carcinoma (PTC) account for up to 25% of the cases, some of which are proven to be associated with aggressive clinical behavior such as tall cell and columnar cell variants. Hobnail variant of PTC (HVPTC) is recently described as a rare and aggressive variant of PTC. Herein, we are reporting a case of HVPTC in a patient who presented with hemoptysis and an intratracheal blood clot that was aspirated and submitted for cytopathological examination. Cytomorphology displayed neoplastic cells with profound micropapillary architecture, elongated nuclei, and prominent hobnail configuration...
August 2017: Diagnostic Cytopathology
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