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Thyroid cytopathology

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https://www.readbyqxmd.com/read/29118474/cytological-evaluation-of-thyroid-lesions-by-nuclear-morphology-and-nuclear-morphometry
#1
R Yashaswini, T N Suresh, A Sagayaraj
Introduction: Fine needle aspiration (FNA) of the thyroid gland is an effective diagnostic method. The Bethesda system for reporting thyroid cytopathology classifies them into six categories and gives implied risk for malignancy and management protocol in each category. Though the system gives specific criteria, diagnostic dilemma still exists. Using nuclear morphometry, we can quantify the number of parameters, such as those related to nuclear size and shape. The evaluation of nuclear morphometry is not well established in thyroid cytology...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29108474/molecular-testing-for-oncogenic-gene-alterations-in-pediatric-thyroid-lesions
#2
Sogol Mostoufi-Moab, Emmanuel Labourier, Lisa Sullivan, Virginia A LiVolsi, Yimei Li, Rui Xiao, Sylvie Beaudenon-Huibregtse, Ken Kazahaya, N Scott Adzick, Zubair W Baloch, Andrew J Bauer
BACKGROUND: Thyroid nodules are less common in pediatric patients (≤18 years) than in adults. The Bethesda System for Reporting Thyroid Cytopathology allows for individual risk stratification, but a significant number of nodules are indeterminate. Incorporating gene mutation panels and gene expression classifiers may aid in pre-operative diagnosis. The overall aim of this study was to assess the prevalence of oncogene alterations in a representative pediatric population and across a broad-spectrum of thyroid tumor diagnoses...
November 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29091573/the-2017-bethesda-system-for-reporting-thyroid-cytopathology
#3
Edmund S Cibas, Syed Z Ali
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) established a standardized, category-based reporting system for thyroid fine-needle aspiration (FNA) specimens. The 2017 revision reaffirms that every thyroid FNA report should begin with one of six diagnostic categories, the names of which remain unchanged since they were first introduced: (i) nondiagnostic or unsatisfactory; (ii) benign; (iii) atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS); (iv) follicular neoplasm or suspicious for a follicular neoplasm; (v) suspicious for malignancy; and (vi) malignant...
November 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29091005/thyroid-nodules-with-nondiagnostic-cytologic-results-follow-up-management-using-ultrasound-patterns-based-on-the-2015-american-thyroid-association-guidelines
#4
Chae Jung Park, Eun-Kyung Kim, Hee Jung Moon, Jung Hyun Yoon, Vivian Youngjean Park, Jin Young Kwak
OBJECTIVE: The purpose of this study was to evaluate the malignancy rate of nodules with nondiagnostic cytologic results based on the American Thyroid Association (ATA) ultrasound (US) patterns and to suggest management guidelines for these nodules. MATERIALS AND METHODS: From January 2013 to December 2014, 441 nodules (≥ 1 cm) were found in 437 patients with nondiagnostic results of ultrasound (US)-guided fine-needle aspiration biopsy (nondiagnostic nodules)...
November 1, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29073758/the-use-of-fine-needle-aspiration-cytology-in-patients-with-thyroid-nodules-in-asia-a-brief-overview-of-studies-from-the-working-group-of-asian-thyroid-fna-cytology
#5
Chan Kwon Jung, Soon Won Hong, Andrey Bychkov, Kennichi Kakudo
Ultrasound-guided fine-needle aspiration (FNA) cytology is the most widely used screening and diagnostic method for thyroid nodules. Although Western guidelines for managing thyroid nodules and the Bethesda System for Reporting Thyroid Cytopathology are widely available throughout Asia, the clinical practices in Asia vary from those of Western countries. Accordingly, the Working Group of Asian Thyroid FNA Cytology encouraged group members to publish their works jointly with the same topic. The articles in this special issue focused on the history of thyroid FNA, FNA performers and interpreters, training programs of cytopathologists and cytotechnicians, staining methods, the reporting system of thyroid FNA, quality assurance programs, ancillary testing, and literature review of their own country's products...
October 27, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29034595/adamantinoma-like-ewing-sarcoma-of-the-parotid-gland-cytopathologic-findings-and-differential-diagnosis
#6
Mohammed T Lilo, Justin A Bishop, Matthew T Olson, Syed Z Ali
Adamantinoma-like Ewing sarcoma (AES) is a rare variant of Ewing sarcoma family of tumors (EFTs), primarily affecting bone and soft tissue. AES has mixed features of Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) and adamantinoma with a complex immunoprofile and EWSR1 gene rearrangements. Herein, we report a 72-year-old male who presented with left parotid mass, right neck mass and thyroid nodules. Fine needle aspiration of the left parotid mass displayed nests of monotonous epithelioid cells with basaloid features in a background of small round blue cells and lymphocytes...
October 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29024469/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-in-the-pediatric-age-group
#7
Esther Diana Rossi, Swati Mehrotra, Ayse Irem Kilic, Iclal Erdem Toslak, Jennifer Lim-Dunham, Maurizio Martini, Guido Fadda, Celestino Pio Lombardi, Luigi Maria Larocca, Güliz A Barkan
BACKGROUND: The most common malignant thyroid neoplasm in children is papillary thyroid carcinoma (PTC). In 2015, the Endocrine Pathology Society introduced the terminology "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) to replace the noninvasive follicular variant of PTC. The objective of the current study was to evaluate previously diagnosed PTC in the pediatric population, reappraise it for NIFTP, and discuss the impact of NIFTP on the risk of malignancy (ROM) for each The Bethesda System for Reporting Thyroid Cytopathology category in the pediatric population...
October 12, 2017: Cancer
https://www.readbyqxmd.com/read/29017315/thyroid-cytology-the-japanese-system-and-experience-at-yamashita-thyroid-hospital
#8
Shinya Satoh, Hiroyuki Yamashita, Kennichi Kakudo
In Japan, fine needle aspiration (FNA) cytology is the most important diagnostic modalities for triaging patients with thyroid nodules. A clinician (endocrinologist, endocrine surgeon, or head and neck surgeon) generally performs FNA cytology at the outpatient clinic, and ultrasound (US)-guided FNA is widespread because US is extremely common and most clinicians are familiar with it. Although almost all FNA thyroid samples are examined by certified cytopathologists and pathologists, some clinicians assess cytological specimens themselves...
October 11, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29017314/thyroid-fine-needle-aspiration-cytology-practice-in-korea
#9
Yoon Jin Cha, Ju Yeon Pyo, Soon Won Hong, Jae Yeon Seok, Kyung-Ju Kim, Jee-Young Han, Jeong Mo Bae, Hyeong Ju Kwon, Yeejeong Kim, Kyueng-Whan Min, Soonae Oak, Sunhee Chang
We reviewed the current status of thyroid fine needle aspiration cytology (FNAC) in Korea. Thyroid aspiration biopsy was first introduced in Korea in 1977. Currently, radiologists aspirate the thyroid nodule under the guidance of ultrasonography, and cytologic interpretation is only legally approved when a cytopathologist makes the diagnosis. In 2008, eight thyroid-related societies came together to form the Korean Thyroid Association. The Korean Society for Cytopathology and the endocrine pathology study group of the Korean Society for Pathologist have been updating the cytologic diagnostic guidelines...
October 11, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28994276/thyroid-fine-needle-aspiration-practice-in-the-philippines
#10
Agustina D Abelardo
Fine-needle aspiration (FNA) is a well accepted initial approach in the management of thyroid lesions. It has gone a long way since its introduction for nearly a century. In the Philippines, FNA of the thyroid started 30 years ago and has been utilized until now as a mainstay in the diagnosis of thyroid malignancy. The procedure is performed by pathologists, endocrinologists, surgeons and radiologists. Majority of pathologists report the cytodiagnosis using a combination of the aspiration biopsy cytology method that closely resembles the histopathologic diagnosis of thyroid disorders and the six-tier nomenclature of The Bethesda System for Reporting Thyroid Cytopathology...
October 5, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28994274/thyroid-cytology-in-india-contemporary-review-and-meta-analysis
#11
Shipra Agarwal, Deepali Jain
Fine needle aspiration cytology (FNAC) is a screening test for triaging thyroid nodules, aiding in subsequent clinical management. However, the advantages have been overshadowed by the multiplicity of reporting systems and a wide range of nomenclature used. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) was formulated in 2007, to give the world a uniform thyroid cytology reporting system, facilitating easy interpretation by the clinicians. Here, we review the status of thyroid FNAC in India in terms of various reporting systems used including a meta-analysis of the previously published data...
October 5, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28982301/low-malignancy-rates-in-fine-needle-aspiration-cytologies-in-a-primary-care-setting-in-germany
#12
Markus Eszlinger, Maha Ullmann, Ilka Ruschenburg, Katharina Böhme, Fabian Görke, Christiane Franzius, Sabine Adam, Thomas Molwitz, Christian Landvogt, Bassam Amro, Anja Hach, Berit Feldmann, Dieter Graf, Antje Wefer, Rainer Niemann, Catharina Bullmann, Günther Klaushenke, Reinhard Santen, Gregor Tönshoff, Velimir Ivancevic, Andreas Kögler, Eberhard Bell, Bernd Lorenz, Gerald Kluge, Christoph Hartenstein, Ralf Paschke
BACKGROUND: Reported results for thyroid nodule fine-needle aspiration (FNA) cytology mainly originate from tertiary centers. However, thyroid nodule FNA cytology is mainly performed in primary care settings for which the distribution of FNA Bethesda categories and their respective malignancy rates are largely unknown. Therefore, this study investigated FNA cytology malignancy rates of a large primary care setting to determine to what extent current evidence-based strategies for the malignancy risk stratification of thyroid nodules are applied and applicable in such primary care settings...
November 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28949123/endocrine-and-neuroendocrine-cytopathology
#13
Massimo Bongiovanni, Stefano LA Rosa, Gerasimos P Sykiotis
Cytology is an easily accessible, cost-effective and safe procedure for the initial evaluation of most endocrine/neuroendocrine lesions. Both fine-needle aspiration cytology and exfoliative cytology have shown good sensitivity and specificity in detecting endocrine/neuroendocrine benign proliferations and malignancies. Thanks to its utility for early diagnosis, cytology has contributed to the decline in mortality of endocrine/neuroendocrine neoplasms. The endocrine system comprises different endocrine organs, such as the thyroid, adrenal glands, paraganglia, parathyroid, pancreas, hypothalamus, pituitary gland, ovaries and testes, which can give rise to non-neoplastic, benign and malignant proliferations...
September 25, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28941185/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-implications-for-the-risk-of-malignancy-rom-in-the-bethesda-system-for-reporting-thyroid-cytopathology-tbsrtc
#14
Haijun Zhou, Zubair W Baloch, Ritu Nayar, Tommaso Bizzarro, Guido Fadda, Deepti Adhikari-Guragain, Joseph Hatem, Luigi M Larocca, Julia Samolczyk, Jamie Slade, Esther Diana Rossi
BACKGROUND: The introduction of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) affects the risk of malignancy (ROM) mostly in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) categories. In this multi-institutional, retrospective study, the authors investigated variations in the impact of an NIFTP diagnosis on the associated ROM for each TBSRTC category with an emphasis on the influence of pathologist and institutional diagnostic thresholds on the ROM...
September 20, 2017: Cancer
https://www.readbyqxmd.com/read/28910894/-diagnostic-values-of-braf-v600e-mutation-analysis-and-bethesda-system-for-reporting-thyroid-cytopathology-in-thyroid-nodules-with-tirads-4-and-5
#15
Y Han, B W Zhao, S Y Li, J G Lyu, J D Shou, H S Xu, H Y Lou, L L Xu, L Gao, S X Xu, J Zhu
Objective: To evaluate the diagnostic efficacies of BRAF(V600E) testing and Bethesda system for reporting thyroid cytopathology (BSRTC) in thyroid nodules with thyroid imaging reporting and data system (TIRADS) category 4 and 5. Methods: A total of 187 thyroid nodules in 187 patients underwent the examinations of ultrasound-guided fine needle aspiration cytology (FNAC) and BRAF(V600E) mutation were analyzed retrospectively. Receive operating characteristic (ROC) curve was used to investigate the diagnostic values of both methods and the clinical application of BRAF(V600E) combined with BSRTC was evaluated...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28898488/prevention-of-total-thyroidectomy-in-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-based-on-combined-interpretation-of-ultrasonographic-and-cytopathologic-results
#16
Sung-Hye You, Kyu Eun Lee, Roh-Eul Yoo, Hye Jeong Choi, Kyeong Cheon Jung, Jae-Kyung Won, Koung Mi Kang, Tae Jin Yoon, Seung Hong Choi, Chul-Ho Sohn, Ji-Hoon Kim
OBJECTIVE: To explore the potential preoperative ultrasonography (US) and cytopathological features to avoid total thyroidectomy in NIFTP CONTEXT: Recently, it has been proposed that that non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) be classified as tumors, rather than cancer. PATIENTS: A total of 142 surgically proven follicular variant papillary thyroid carcinomas (FVPTCs; 45 NIFTP, 97 non-NIFTP; mean size: 20.4±11.0 mm, range: 10...
September 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28828911/cost-effectiveness-of-gene-expression-classifier-testing-of-indeterminate-thyroid-nodules-utilizing-a-real-cohort-comparator
#17
Scott Shapiro, Majed Pharaon, Brian Kellermeyer
Objective To predict the cost-effectiveness of implementing routine gene expression classifier testing for thyroid nodules with indeterminate fine-needle aspiration cytology, by utilizing a real cohort of patients as a comparator. Study Design Cost-effectiveness analysis of a retrospective cohort compared with a simulated cohort. Setting Tertiary academic medical center. Subjects and Methods We reviewed the records of all patients who underwent ultrasound-guided fine-needle aspiration from 2010 to 2014 at a tertiary academic medical center...
October 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28811803/a-study-of-galactin-3-on-fine-needle-aspiration-as-a-diagnostic-marker-differentiating-benign-from-malignant-thyroid-neoplasm
#18
Alliya Muzafar, Mulazim Hussain Bukhari, Ihtesham Uddin Qureshi
BACKGROUND & OBJECTIVE: Thyroid nodules are very common in our setup and their diagnosis on fine needle aspiration is not easy and is a taxing affair. It is a challenge to differentiate between follicular adenoma and follicular carcinoma without histology. Our objective was to investigate the role of Galectin-3 in fine needle aspirates of thyroid nodules as a prospective diagnostic marker and consequently its ability to differentiate benign from malignant neoplasms. METHODS: The research was conducted at the department of Pathology, King Edward Medical University, in association with other teaching institutions of Lahore from June 2012 to July 2014...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28806882/long-term-outcomes-of-lateral-neck-dissection-in-patients-with-recurrent-or-persistent-well-differentiated-thyroid-cancer
#19
Steven B Chinn, Mark E Zafereo, Steven G Waguespack, Beth S Edeiken, Dianna B Roberts, Gary L Clayman
BACKGROUND: Well-differentiated thyroid carcinoma (WDTC) has a high predilection for regional metastatic spread. Rates for WDTC lateral neck recurrence are reported to be as high as 24% in patients after initial thyroidectomy, lateral neck surgery, and adjuvant radioactive (RAI) iodine treatment. The objective of the study was to evaluate the efficacy, safety, and long-term outcome of comprehensive lateral neck dissection (LND) of levels II-V for recurrent or persistent WDTC in a tertiary referral center...
October 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28797549/predicting-thyroid-nodule-malignancy-at-several-prevalence-values-with-a-combined-bethesda-molecular-test
#20
Hélène Lasolle, Benjamin Riche, Myriam Decaussin-Petrucci, Emmanuelle Dantony, Véronique Lapras, Catherine Cornu, Joël Lachuer, Jean-Louis Peix, Jean-Christophe Lifante, Oana-Maria Capraru, Samia Selmi-Ruby, Bernard Rousset, Françoise Borson-Chazot, Pascal Roy
Investigation of thyroid nodules using fine-needle aspiration cytology (FNAC) gives indeterminate results in up to 30% of samples using the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). We present a combined Bethesda-molecular predictor of nodule malignancy to improve the accuracy of the preoperative diagnosis of thyroid nodules. To detect a molecular signature of thyroid nodule malignancy, a molecular test was performed on FNACs from 128 thyroid nodules from prospectively included patients, collected in a tertiary center...
October 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
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