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Thyroid cytopathology

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https://www.readbyqxmd.com/read/28910894/-diagnostic-values-of-braf-v600e-mutation-analysis-and-bethesda-system-for-reporting-thyroid-cytopathology-in-thyroid-nodules-with-tirads-4-and-5
#1
Y Han, B W Zhao, S Y Li, J G Lyu, J D Shou, H S Xu, H Y Lou, L L Xu, L Gao, S X Xu, J Zhu
Objective: To evaluate the diagnostic efficacies of BRAF(V600E) testing and Bethesda system for reporting thyroid cytopathology (BSRTC) in thyroid nodules with thyroid imaging reporting and data system (TIRADS) category 4 and 5. Methods: A total of 187 thyroid nodules in 187 patients underwent the examinations of ultrasound-guided fine needle aspiration cytology (FNAC) and BRAF(V600E) mutation were analyzed retrospectively. Receive operating characteristic (ROC) curve was used to investigate the diagnostic values of both methods and the clinical application of BRAF(V600E) combined with BSRTC was evaluated...
September 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28898488/prevention-of-total-thyroidectomy-in-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp-based-on-combined-interpretation-of-ultrasonographic-and-cytopathologic-results
#2
Sung-Hye You, Kyu Eun Lee, Roh-Eul Yoo, Hye Jeong Choi, Kyeong Cheon Jung, Jae-Kyung Won, Koung Mi Kang, Tae Jin Yoon, Seung Hong Choi, Chul-Ho Sohn, Ji-Hoon Kim
OBJECTIVE: To explore the potential preoperative ultrasonography (US) and cytopathological features to avoid total thyroidectomy in NIFTP CONTEXT: Recently, it has been proposed that that non-invasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) be classified as tumors, rather than cancer. PATIENTS: A total of 142 surgically proven follicular variant papillary thyroid carcinomas (FVPTCs; 45 NIFTP, 97 non-NIFTP; mean size: 20.4±11.0 mm, range: 10...
September 12, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28828911/cost-effectiveness-of-gene-expression-classifier-testing-of-indeterminate-thyroid-nodules-utilizing-a-real-cohort-comparator
#3
Scott Shapiro, Majed Pharaon, Brian Kellermeyer
Objective To predict the cost-effectiveness of implementing routine gene expression classifier testing for thyroid nodules with indeterminate fine-needle aspiration cytology, by utilizing a real cohort of patients as a comparator. Study Design Cost-effectiveness analysis of a retrospective cohort compared with a simulated cohort. Setting Tertiary academic medical center. Subjects and Methods We reviewed the records of all patients who underwent ultrasound-guided fine-needle aspiration from 2010 to 2014 at a tertiary academic medical center...
August 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28811803/a-study-of-galactin-3-on-fine-needle-aspiration-as-a-diagnostic-marker-differentiating-benign-from-malignant-thyroid-neoplasm
#4
Alliya Muzafar, Mulazim Hussain Bukhari, Ihtesham Uddin Qureshi
BACKGROUND & OBJECTIVE: Thyroid nodules are very common in our setup and their diagnosis on fine needle aspiration is not easy and is a taxing affair. It is a challenge to differentiate between follicular adenoma and follicular carcinoma without histology. Our objective was to investigate the role of Galectin-3 in fine needle aspirates of thyroid nodules as a prospective diagnostic marker and consequently its ability to differentiate benign from malignant neoplasms. METHODS: The research was conducted at the department of Pathology, King Edward Medical University, in association with other teaching institutions of Lahore from June 2012 to July 2014...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28806882/long-term-outcomes-of-lateral-neck-dissection-in-patients-with-recurrent-or-persistent-well-differentiated-thyroid-cancer
#5
Steven B Chinn, Mark E Zafereo, Steven G Waguespack, Beth S Edeiken, Dianna B Roberts, Gary L Clayman
BACKGROUND: Well-differentiated thyroid carcinoma (WDTC) has a high predilection for regional metastatic spread. Rates for WDTC lateral neck recurrence are reported to be as high as 24% in patients after initial thyroidectomy, lateral neck surgery, and adjuvant radioactive (RAI) iodine treatment. The objective of the study was to evaluate the efficacy, safety, and long-term outcome of comprehensive lateral neck dissection (LND) of levels II-V for recurrent or persistent WDTC in a tertiary referral center...
September 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28797549/predicting-thyroid-nodule-malignancy-at-several-prevalence-values-with-a-combined-bethesda-molecular-test
#6
Hélène Lasolle, Benjamin Riche, Myriam Decaussin-Petrucci, Emmanuelle Dantony, Véronique Lapras, Catherine Cornu, Joël Lachuer, Jean-Louis Peix, Jean-Christophe Lifante, Oana-Maria Capraru, Samia Selmi-Ruby, Bernard Rousset, Françoise Borson-Chazot, Pascal Roy
Investigation of thyroid nodules using fine-needle aspiration cytology (FNAC) gives indeterminate results in up to 30% of samples using the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). We present a combined Bethesda-molecular predictor of nodule malignancy to improve the accuracy of the preoperative diagnosis of thyroid nodules. To detect a molecular signature of thyroid nodule malignancy, a molecular test was performed on FNACs from 128 thyroid nodules from prospectively included patients, collected in a tertiary center...
October 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28759963/nondiagnostic-cytological-results-on-ultrasound-guided-fine-needle-aspiration-does-the-thyroid-nodule-depth-matter
#7
Jia-Jing Xia, Meng-Sen Li, Li Zhen, You-Zhen Shi
OBJECTIVE: To evaluate whether thyroid nodule depth and other ultrasound features can predict nondiagnostic cytological results on ultrasound-guided fine needle aspiration. MATERIAL AND METHODS: This retrospective study included 412 thyroid nodules that underwent ultrasound-guided fine needle aspiration from 2014 to 2015. The nodules were classified as nondiagnostic and diagnostic by the cytopathological results. Clinical information of the patients (ie., age, sex) and ultrasound features (ie...
July 25, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28741442/a-systematic-review-of-the-methods-of-diagnostic-accuracy-studies-of-the-afirma-gene-expression-classifier
#8
Quan-Yang Duh, Naifa L Busaidy, Catherine Rahilly-Tierney, Hossein Gharib, Gregory Randolph
BACKGROUND: The Afirma(®) Gene Expression Classifier (GEC) risk stratifies The Bethesda System for the Reporting of Thyroid Cytopathology class III/IV (indeterminate) thyroid nodules (ITNs) as suspicious for malignancy or benign. Several authors have published studies describing the diagnostic accuracy of the GEC. However, the quality of these methods has not been rigorously examined. SUMMARY: In this study, MEDLINE and EMBASE were searched for studies published between January 1, 2010, and June 30, 2016, examining the sensitivity, specificity, negative predictive value, and positive predictive value of the GEC...
August 17, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28734572/experience-of-the-implementation-of-rapid-on-site-evaluation-in-ultrasound-guided-fine-needle-aspiration-biopsy-of-thyroid-nodules
#9
Flor Marina Medina Chamorro, José Abella Calle, Juliana Escobar Stein, Lina Merchancano, Andrés Mauricio Mendoza Briñez, Andrés Arturo Pulido Wilches
OBJECTIVE: To evaluate the effect of the implementation of the rapid on-site evaluation (ROSE) technique in ultrasound-guided fine-needle aspiration biopsy of thyroid nodules. MATERIALS AND METHODS: We conducted an observational and retrospective study approved by the Institutional Ethics Committee as an investigation without risk. Between January 2012 and December 2015, 892 ultrasound-guided fine-needle aspiration biopsy procedures were performed under ultrasound guidance...
June 27, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28701827/malignancy-rate-in-thyroid-nodules-categorized-as-atypia-of-undetermined-significance-or-follicular-lesion-of-undetermined-significance-an-institutional-experience
#10
Smita Chandra, Harish Chandra, Sampan S Bisht
INTRODUCTION: Atypia of undetermined significance (AUS) or follicular lesion of undetermined significance (FLUS) of Bethesda system for reporting thyroid cytopathology has emerged as most controversial category due to its heterogeneity and inconsistent usage. Initially associated risk of malignancy was estimated to be about 5-15%, but eventually different results have been obtained across institutions due to variable follow-ups and interpretation. The present study was conducted to evaluate the rate of malignancy along with appropriate management in this category...
July 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28701706/intraoperative-frozen-section-can-be-reduced-in-thyroid-nodules-classified-as-bethesda-categories-v-and-vi
#11
Jing Huang, Jieli Luo, Jianshe Chen, Yang Sun, Chao Zhang, Kanlun Xu, Qin Ye, Pintong Huang
Intraoperative frozen section (FS) can be reduced during thyroid lobectomy according to the results of fine needle aspiration (FNA). We evaluated the role of intraoperative FS in thyroid nodules with different diagnostic categories of the Bethesda System for Reporting Thyroid Cytopathology by FNA. This retrospective study included 1,235 nodules collected via thyroidectomy with both preoperative FNA and intraoperative FS at the Second Affiliated Hospital of Zhejiang University School of Medicine, from January 2011 to January 2014...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28699990/likelihood-of-malignancy-in-thyroid-nodules-according-to-a-proposed-thyroid-imaging-reporting-and-data-system-ti-rads-classification-merging-suspicious-and-benign-ultrasound-features
#12
Ricardo Luiz Costantin Delfim, Leticia Carrasco Garcez da Veiga, Ana Paula Aguiar Vidal, Flávia Paiva Proença Lobo Lopes, Mário Vaisman, Patrícia de Fatima Dos Santos Teixeira
Objective: The aim of this study was to describe the ultrasound features of benign and malignant thyroid nodules and evaluate the likelihood of malignancy associated with each feature according to the Bethesda System for Reporting Thyroid Cytopathology and histopathology. With this analysis, we propose a new TI-RADS classification system. Materials and methods: The likelihood of malignancy from ultrasound features were assessed in 1413 thyroid nodules according to the Bethesda System for Reporting Thyroid Cytopathology and histopathological findings...
May 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28696007/comparison-of-conventional-cytology-and-surepath-in-split-thyroid-fine-needle-aspiration-materials
#13
D Sahin, D Yilmazbayhan, P Firat, U P Hacisalihoglu, S H Kirimlioglu, E Celenk, R Arslan
OBJECTIVE: The aim of the present study was to compare the cytomorphological features and cytopathological diagnoses in thyroid aspiration materials prepared by SurePath® (SP) and conventional cytology (CC). MATERIALS AND METHODS: Fine needle aspiration (FNA) materials from 180 thyroid nodules were divided into two groups to prepare three conventional smears and one SP slide. Twenty-nine cytomorphological features of thyroid lesions were compared in the CC and SP slides...
July 11, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/28689321/underestimated-risk-of-cancer-in-solitary-thyroid-nodules-%C3%A2-3%C3%A2-cm-reported-as-benign
#14
Sohail Bakkar, Anello Marcello Poma, Caterina Corsini, Mario Miccoli, Carlo Enrico Ambrosini, Paolo Miccoli
BACKGROUND: The study aims to assess the risk of cancer in solitary thyroid nodules ≥30 mm in size reported as Bethesda II, and its implications. METHOD: The clinical records of 202 patients, who underwent thyroid lobectomy for solitary nodules measuring ≥30 mm, reported as Bethesda II on preoperative FNAC between Jan 2015 and Apr 2016 were reviewed. Data collected included nodule size and consistency, and final histopathology results. The risk of cancer and the recommended management according to ATA guidelines were the outcomes of interest...
July 8, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28657511/validation-of-american-thyroid-association-ultrasound-risk-assessment-of-thyroid-nodules-selected-for-ultrasound-fine-needle-aspiration
#15
Alice L Tang, Mercedes Falciglia, Huaitao Yang, Jonathan R Mark, David L Steward
OBJECTIVE: The aim of this study was to validate the American Thyroid Association (ATA) sonographic risk assessment of thyroid nodules. METHODS: The ATA sonographic risk assessment was prospectively applied to 206 thyroid nodules selected for ultrasound-guided fine-needle aspiration (US-FNA), and analyzed with The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC), as well as surgical pathology for the subset undergoing surgical excision. RESULTS: The analysis included 206 thyroid nodules averaging 2...
August 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28626115/reappraisal-of-cyst-fluid-only-on-thyroid-fine-needle-aspiration-cytology
#16
Nami Takada, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Akira Miyauchi
According to the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), cyst fluid only (CFO) cases are classified in the non-diagnostic category. To date, no large study focusing on CFO has been conducted. To reassess the diagnostic significance of CFO, we compared CFO nodules with non-diagnostic nodules excluding CFO (ND-other). We reviewed the conventional thyroid smears of 715 CFO and 766 ND-other nodules. We compared the timing of and findings at re-aspiration, the histology of resected specimens, and the proportion of malignant nodules between the two groups...
June 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28609825/the-use-of-the-bethesda-system-for-reporting-thyroid-cytopathology-in-korea-a-nationwide-multicenter-survey-by-the-korean-society-of-endocrine-pathologists
#17
Mimi Kim, Hyo Jin Park, Hye Sook Min, Hyeong Ju Kwon, Chan Kwon Jung, Seoung Wan Chae, Hyun Ju Yoo, Yoo Duk Choi, Mi Ja Lee, Jeong Ja Kwak, Dong Eun Song, Dong Hoon Kim, Hye Kyung Lee, Ji Yeon Kim, Sook Hee Hong, Jang Sihn Sohn, Hyun Seung Lee, So Yeon Park, Soon Won Hong, Mi Kyung Shin
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has standardized the reporting of thyroid cytology specimens. The objective of the current study was to evaluate the nationwide usage of TBSRTC and assess the malignancy rates in each category of TBSRTC in Korea. METHODS: Questionnaire surveys were used for data collection on the fine needle aspiration (FNA) of thyroid nodules at 74 institutes in 2012. The incidences and follow-up malignancy rates of each category diagnosed from January to December, 2011, in each institute were also collected and analyzed...
July 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28570751/preoperative-clinicopathological-characteristics-of-patients-with-solitary-encapsulated-follicular-variants-of-papillary-thyroid-carcinomas
#18
Hyemi Kwon, Min Ji Jeon, Jong Ho Yoon, Suck Joon Hong, Jeong Hyun Lee, Tae Yong Kim, Young Kee Shong, Won Bae Kim, Won Gu Kim, Dong Eun Song
BACKGROUND AND OBJECTIVES: Clinical outcomes in patients with the follicular variant of papillary thyroid carcinoma (FVPTC) tend to vary according to the pathological subtypes. We aimed to evaluate the clinicopathological characteristics including preoperative radiological and cytopathological diagnoses in patients with solitary encapsulated FVPTCs (EFVPTCs) to prove the preoperative assessment dilemma. METHODS: Patients with solitary FVPTCs who underwent thyroid surgery were included...
June 1, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28544576/atypical-adenoma-of-the-thyroid-diagnosed-as-anaplastic-cancer-by-cytopathology
#19
Hiromitsu Hatakeyama, Kimiko Hoshino, Kenji Mizoguchi, Takayoshi Suzuki, Kanako C Hatanaka, Yukie Yamaya, Satoshi Kano, Takatsugu Mizumachi, Akihiro Homma
Atypical adenoma of the thyroid is a rare form of tumor, and its accurate diagnosis prior to surgical resection is difficult as the histological and pathological morphologies are very similar to those of anaplastic thyroid carcinoma (ATC), and its anaplastic transformation remains to be elucidated. We reported a case of a 75-year-old female with a thyroid isthmus nodule diagnosed repeatedly by FNAC as anaplastic carcinoma. Both the first and second FNAC specimen slides showed a large number of scattered or aggregated atypical cells consisting of large, pleomorphic nuclei with irregular membranes, chromatin clumps and prominent nucleoli...
May 22, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28525461/18f-fdg-pet-ct-of-papillary-carcinoma-in-a-lateral-thyroglossal-duct-cyst
#20
Christos Sachpekidis, Matthias S Dettmer, Sabine Weidner, Roland Giger, Jan Wartenberg
A 69-year-old man presented with bulging of the right oropharyngeal wall, which revealed cytopathologically malignant cells. The man underwent MRI and F-FDG PET/CT, which demonstrated a cystic parapharyngeal lesion with an F-FDG-avid soft tissue component and right cervical lymph node. The patient was operated on and showed thyroid cancer in normal thyroid tissue, compatible with a papillary thyroid carcinoma in a lateral thyroglossal duct cyst and 2 ipsilateral lymph node metastases. Despite its rarity, papillary thyroid carcinoma in a thyroglossal duct cyst should be kept as one of the differential diagnoses in patients presenting with parapharyngeal cystic lesion...
August 2017: Clinical Nuclear Medicine
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