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Thyroid cytopathology

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https://www.readbyqxmd.com/read/29742978/needle-biopsy-of-routine-thyroid-nodules-should-be-performed-using-a-capillary-action-technique-with-24-27-gauge-needles-a-systematic-review-and-meta-analysis
#1
William Moss, Andrey Finegersh, John Pang, Joseph A Califano, Charles S Coffey, Ryan Orosco, Kevin T Brumund
BACKGROUND: Fine needle biopsy is the international standard for diagnostic evaluation of thyroid nodules. There is a lack of consensus regarding the optimal fine needle biopsy technique. The implementation of capillary action versus aspiration and the optimal needle gauge remain topics of debate. METHODS: A systematic review of the Medline, Embase and Cochrane databases was performed in accordance with PRISMA guidelines. Articles evaluating the effects of capillary action vs...
May 10, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29704233/the-mutational-analysis-in-the-diagnostic-work-up-of-thyroid-nodules-the-real-impact-in-a-center-with-large-experience-in-thyroid-cytopathology
#2
E Macerola, T Rago, A Proietti, F Basolo, P Vitti
PURPOSE: Fine-needle aspiration (FNA) cytology is a mainstay in the evaluation of thyroid nodules, but fails to reach reliable results in 25-30% of cases. The role of molecular markers in helping clinical decisions has been investigated for the last years, but their clinical usefulness is still unsettled. METHODS: Mutation analysis of BRAF, RAS genes and TERT promoter was performed in a series of 617 consecutive cytological specimens undergoing FNA. RESULTS: The 617 nodules had the following cytological diagnosis: non diagnostic 22 (3...
April 27, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29696036/malignancy-rates-in-thyroid-nodules-classified-as-bethesda-categories-iii-and-iv-retrospective-data-from-a-tertiary-center
#3
Beatriz Godoi Cavalheiro, Ana Kober Nogueira Leite, Leandro Luongo de Matos, Aline Palermo Miazaki, Jan Marcel Ientile, Marco Aurelio V Kulcsar, Claudio Roberto Cernea
Background: Thyroid fine needle aspiration (FNA) has a well-established role in the diagnosis of thyroid nodules, and the "Bethesda system for reporting thyroid cytopathology" is used to interpret FNA results. Bethesda categories III and IV encompass varying risks of malignancy. In addition, there is some debate in the literature about how to select among many acceptable treatment approaches. Objectives: To establish an association between these 2 cytological categories and malignancy rates in patients treated in a referral tertiary cancer center, where surgical treatment is recommended for all these patients...
January 2018: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29680915/medullary-thyroid-carcinoma-application-of-thyroid-imaging-reporting-and-data-system-ti-rads-classification
#4
Gabin Yun, Yeo Koon Kim, Sang Il Choi, Ji-Hoon Kim
PURPOSE: To evaluate the applicability of ultrasound (US)-based Thyroid Imaging Reporting and Data System (TI-RADS) for evaluating medullary thyroid carcinoma (MTC). MATERIALS AND METHODS: US images and medical records of patients with cytopathology-confirmed MTC between June 2003 and November 2016 were retrospectively reviewed. Four independent reviewers (two experienced and two inexperienced radiologists) evaluated 57 pre-operative US images of patients with MTC for shape, composition, echogenicity, margin, calcification of the MTC nodules, and categorized the nodules using TI-RADS classification...
April 21, 2018: Endocrine
https://www.readbyqxmd.com/read/29626393/cyto-morphologic-spectrum-of-thyroid-lesions-in-children
#5
Priya Pathak, Pooja Sharma, Aditi Daga, Sonal Sharma
INTRODUCTION: Fine needle aspiration (FNA) is routinely used in triaging thyroid lesions in adults. However, role of FNA in pediatric thyroid lesions is less studied. AIM AND OBJECTIVE: To study the cyto-morphologic spectrum of thyroid lesions in pediatric population. MATERIALS AND METHODS: A retrospective analysis (duration-6 years) of thyroid FNA for patients who were 18 years or younger was conducted. The aspirates were classified according to the Bethesda System for Reporting Cytopathology...
April 6, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29619406/unique-cytologic-features-of-thyroiditis-caused-by-immune-checkpoint-inhibitor-therapy-for-malignant-melanoma
#6
Trevor E Angell, Le Min, Tad J Wieczorek, F Stephen Hodi
Blockade of immune checkpoint molecules to reverse cancer-induced immune suppression can improve anti-tumor immune responses in cancer patients. Monoclonal antibodies targeting two such molecules, Programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA-4) have shown clinical benefit in the treatment of advanced malignancies, including metastatic melanoma. Adverse effects of these immune checkpoint inhibitors include immune-related adverse events (irAE) and the inducing of new autoimmunity, of which one of the most common is autoimmune thyroiditis...
March 2018: Genes & Diseases
https://www.readbyqxmd.com/read/29614546/cytologic-diagnosis-of-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-and-its-impact-on-the-risk-of-malignancy-in-the-bethesda-system-for-reporting-thyroid-cytopathology-an-institutional-experience
#7
Milim Kim, Joung Eun Kim, Hyun Jeong Kim, Yul Ri Chung, Yoonjin Kwak, So Yeon Park
Background: This study was performed to analyze cytologic diagnosis of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) and its impact on the risk of malignancy (ROM) in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). Materials and Methods: 5549 cases of thyroid fine-needle aspiration cytology (FNAC) diagnosed between 2012 and 2014 were included in this study. Diagnostic categories based on TBSRTC were compared with final surgical diagnoses, and the ROM in each category was calculated both including and excluding NIFTP from the malignant lesions...
April 3, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29610616/ovarian-strumal-carcinoid-tumour-case-report
#8
Vesna S Antovska, Milka Trajanova, Iskra Krstevska, Irena Gosheva, Jasmina Chelebieva, Irina Prodanova
BACKGROUND: Ovarian strumal carcinoid is a germ cell tumour characterised by a mixture of thyroid tissue and carcinoid. Ovarian struma is a very rare occurrence with 0.3-1% incidence of all ovarian tumours and 3% of mature teratomas. Primary carcinoid ovarian tumours are still uncommon as a part of mature teratoma or mucinous cystadenoma. There are four major variants of a carcinoid tumour: insular, trabecular, strumal and mucinous. A strumal carcinoid is an unusual form of ovarian teratoma composed of an intimate admixture of thyroid/carcinoid tissues...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29605452/efficiency-of-the-bethesda-system-for-thyroid-cytopathology
#9
Ismael Mora-Guzmán, José Luis Muñoz de Nova, Cristina Marín-Campos, José Antonio Jiménez-Heffernan, Juan Julián Cuesta Pérez, Marcos Lahera Vargas, Emma Torres Mínguez, Elena Martín-Pérez
INTRODUCTION: Fine-needle aspiration biopsies are a key tool for preoperative assessment of thyroid nodules, and the Bethesda system is the preferred method to report cytological analysis. The purpose of this study is to assess the efficiency of the Bethesda system to identify the malignancy risk of thyroid nodules. METHODS: Patients who underwent thyroid surgery between June 2010 and June 2017 were included. Samples were classified into 6categories according to rates of malignancy associated with each diagnostic category...
March 28, 2018: Cirugía Española
https://www.readbyqxmd.com/read/29596039/subclassification-of-bethesda-atypical-and-follicular-neoplasm-categories-according-to-nuclear-and-architectural-atypia-improves-discrimination-of-thyroid-malignancy-risk
#10
Joel Xue Yi Lim, Min En Nga, Dedrick Kok Hong Chan, Wee Boon Tan, Rajeev Parameswaran, Kee Yuan Ngiam
BACKGROUND: Although The Bethesda System for Reporting Thyroid Cytopathology has provided clinicians with a standardized classification scheme for the diagnosis of thyroid fine-needle aspiration cytology (FNAC) specimens, the indeterminate categories of Bethesda III (B3)-atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS)-and Bethesda IV (B4)-follicular neoplasm/suspicious for follicular neoplasm (FN/SFN)-continue to pose challenges with regards to ideal diagnostic and therapeutic management...
March 29, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29595320/thyroid-nodules-and-cancer-in-children-and-adolescents-affected-by-hashimoto-s-thyroiditis
#11
Ji-Hye Won, Ji Ye Lee, Hyun Sook Hong, Sun Hye Jeong
OBJECTIVES: To investigate the rates of thyroid nodules and cancer in pediatric cases of Hashimoto's thyroiditis (HT) in Korea. METHODS: We retrospectively reviewed 89 pediatric and adolescent patients (age, 3-18.0 years) with HT who underwent thyroid ultrasonography (US) at our institution from February 2006 to July 2016. The diagnosis of HT was based on the presence of thyroid autoantibodies. The presence of any thyroid nodules with US and cytopathologic features was analyzed...
March 29, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29591914/the-bethesda-system-for-reporting-thyroid-cytopathology-explained-for-practitioners-frequently-asked-questions
#12
Massimo Bongiovanni, Georgios E Papadakis, Nathalie Rouiller, Laura Marino, Faiza Lamine, Bettina Bisig, Sonia Ziadi, Gerasimos P Sykiotis
The recent update of the Bethesda system for reporting thyroid cytology (TBSRTC) is a very important development in the evaluation of thyroid nodules. Clinical experience and scientific literature both show that practitioners performing thyroid FNA are accustomed to basing the clinical management of patients on reports using TBSRTC. Specifically, clinicians are familiar with the per cent risk of malignancy (ROM) corresponding to each TBSRTC diagnostic category (DC), as well as with the respective recommendation for clinical management...
March 28, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29581701/thyroid-nodule-management-thyroid-stimulating-hormone-ultrasound-and-cytological-classification-system-for-predicting-malignancy
#13
Mohamed Abdulaziz Al Dawish, Asirvatham Alwin Robert, Mohammed A Thabet, Rim Braham
Background/objectives: Thyroid nodule (TN) is a common thyroid disorder globally, and the incidence has been increasing in recent decades. The objective of this study was to determine the contribution of thyroid-stimulating hormone (TSH), ultrasound (US), and cytological classification system for predicting malignancy among the surgically excised nodules. Design and methods: A retrospective analysis was performed between January 2012 and December 2014, using data drawn from 1188 patients (15-90 years), who had 1433 TN and fine-needle aspiration in Prince Sultan Military Medical City, Saudi Arabia...
2018: Cancer Informatics
https://www.readbyqxmd.com/read/29577488/cytomorphology-and-sonographic-features-of-ectopic-thymic-tissue-diagnosed-in-paediatric-fna-biopsies
#14
F A Escobar, L Pantanowitz, J L Picarsic, F E Craig, J P Simons, P A Viswanathan, S Yilmaz, S E Monaco
INTRODUCTION: Ectopic thymic tissue can arise as an asymptomatic neck mass, which may be detected on imaging studies. The aim of this study was to determine the incidence of ectopic thymic tissue in paediatric FNAs and to the correlate clinical, radiological and cytomorphological findings. METHODS: FNAs in children with neck and mediastinal lesions performed between January 2012 and July 2016 were reviewed for cases of ectopic thymus. These were then evaluated and correlated with the cytology findings...
March 26, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29531571/classification-of-thyroid-fine-needle-aspiration-cytology-into-bethesda-categories-an-institutional-experience-and-review-of-the-literature
#15
Safa Alshaikh, Zainab Harb, Eman Aljufairi, S Ali Almahari
Background: Fine-needle aspiration cytology (FNAC) of thyroid is the initial screening test for thyroid nodules. The Bethesda system classifies thyroid FNAC into six categories. Each category is linked to a malignancy risk and has a recommended clinical management. The aim of this study is to analyze the thyroid cytology smears by Bethesda system and to correlate the diagnosis of cytopathology with histopathology, whenever surgery was done. Materials and Methods: This study presents our experience with the Bethesda system in 681 thyroid FNAs from 632 patients in the period between January 2013 and December 2016...
2018: CytoJournal
https://www.readbyqxmd.com/read/29497456/diagnostic-importance-of-cd56-with-fine-needle-aspiration-cytology-in-suspected-papillary-thyroid-carcinoma-cases
#16
Ozgen Arslan Solmaz
Background: Palpable thyroid nodules can be found in 4%-7% of the adult population; however, <5% of thyroid nodules are malignant. Immunohistochemical markers, such as CD56, can be used to make a differential diagnosis between benign and malignant lesions. To increase the accuracy of the diagnosis and distinguish the malignant aspirates from the benign ones, chose to evaluate CD56, which is normally found in benign thyroid tissue. Methods: A total of 53 fine-needle aspirate samples from patients diagnosed with suspected papillary thyroid carcinoma (PTC) were included prospectively...
2018: CytoJournal
https://www.readbyqxmd.com/read/29486467/atypia-of-undetermined-significance-in-thyroid-fine-needle-aspirations-follow-up-and-outcome-experience-in-newfoundland-canada
#17
Polycarp Erivwo, Chandrani Ghosh
INTRODUCTION: The rates of atypia of undetermined significance (AUS) by fine-needle aspiration (FNA) and malignant outcomes have been estimated at < 7% and 5-15%, respectively. Initial AUS diagnosis is followed up clinically with serial ultrasounds, repeat FNA, molecular testing, or direct surgery. We investigated the incidence, follow-up modalities, and final outcomes of AUS in Newfoundland. METHODS: All cases of AUS diagnosed at the Eastern Health Cytology Laboratory between 1 January 2010 and 31 December 2013 were identified...
2018: Acta Cytologica
https://www.readbyqxmd.com/read/29476382/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-in-asian-practice-perspectives-for-surgical-pathology-and-cytopathology
#18
REVIEW
Andrey Bychkov, Chan Kwon Jung, Zhiyan Liu, Kennichi Kakudo
The introduction of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was initiated and promoted by pathologists. Recent Asian studies added new knowledge to the existing literature to aid a better understanding of NIFTP. Our original data and the results of a meta-analysis suggest that the initial rate of NIFTP has been overestimated, averaging 9.1% (95% confidence interval [CI] 6.0-12.7%) of all papillary thyroid cancers worldwide. The incidence of NIFTP in the Asian population (1...
February 23, 2018: Endocrine Pathology
https://www.readbyqxmd.com/read/29469940/different-qualifiers-of-aus-flus-thyroid-fna-have-distinct-braf-ras-ret-ptc-and-pax8-pparg-alterations
#19
Claudio Bellevicine, Roberta Sgariglia, Ilaria Migliatico, Elena Vigliar, Melania D'Anna, Maria Antonia Nacchio, Nicola Serra, Umberto Malapelle, Massimo Bongiovanni, Giancarlo Troncone
BACKGROUND: The Bethesda System for Reporting Thyroid Cytopathology category of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) includes fine-needle aspiration (FNA) specimens that cannot straightforwardly be classified as benign or malignant. To determine whether morphological subcategorization based on atypia qualifiers and molecular testing could improve malignancy risk stratification of AUS/FLUS patients, this study assessed the correlation between these qualifiers and the molecular alterations commonly harbored by thyroid neoplasms...
February 22, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/29462847/use-of-the-ultrasound-based-total-malignancy-score-in-the-management-of-thyroid-nodules
#20
Giovanni Guido Pompili, Silvia Tresoldi, Anna Ravelli, Alessandra Primolevo, Giovanni Di Leo, Gianpaolo Carrafiello
Purpose: The purpose of this study was to validate the role of the total malignancy score (TMS) in identifying thyroid nodules suspicious for malignancy through the sum of their ultrasound features. Methods: The local ethical committee approved this prospective observational study. We examined 231 nodules in 231 consecutive patients (164 females and 67 males; age range, 20 to 87 years; median age, 59 years; interquartile range, 48 to 70 years) who underwent ultrasound followed by fine-needle aspiration cytology (FNAC)...
January 6, 2018: Ultrasonography
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