keyword
https://read.qxmd.com/read/37291355/valuable-effects-of-lactobacillus-and-citicoline-on-steatohepatitis-role-of-nrf2-ho-1-and-gut-microbiota
#21
JOURNAL ARTICLE
Ahmed M El-Baz, Amira M El-Ganiny, Doaa Hellal, Hala M Anwer, Hend A Abd El-Aziz, Ibrahim E Tharwat, Mohamed A El-Adawy, Shehab El-Din M Helal, Menna Tallah A Mohamed, Tassnim M Azb, Hanya M Elshafaey, AbdulRahman A Shalata, Sahar M Elmeligi, Noran H Abdelbary, Attalla F El-Kott, Fatimah A Al-Saeed, Eman T Salem, Mohamed M Adel El-Sokkary, Ahmed Shata, Ahmed A Shabaan
Non-alcoholic steatohepatitis (NASH) is a more dangerous form of chronic non-alcoholic fatty liver disease (NAFLD). In the current investigation, the influence of citicoline on high-fat diet (HFD)-induced NASH was examined, both alone and in combination with Lactobacillus (probiotic). NASH was induced by feeding HFD (10% sugar, 10% lard stearin, 2% cholesterol, and 0.5% cholic acid) to rats for 13 weeks and received single i.p. injection of streptozotocin (STZ, 30 mg/kg) after 4 weeks. Citicoline was given at two dose levels (250 mg and 500 mg, i...
June 8, 2023: AMB Express
https://read.qxmd.com/read/37189743/urolithin-a-s-antioxidative-anti-inflammatory-and-antiapoptotic-activities-mitigate-doxorubicin-induced-liver-injury-in-wistar-rats
#22
JOURNAL ARTICLE
Shahid Karim, Batoul Madani, Abdulhadi S Burzangi, Mohammed Alsieni, Mohammed A Bazuhair, Maha Jamal, Hussam Daghistani, Mohammed O Barasheed, Huda Alkreathy, Mohammad Ahmed Khan, Lateef M Khan
Human colon microbiota produce a metabolite called urolithin A (URO A) from ellagic acid and linked compounds, and this metabolite has been demonstrated to have antioxidant, anti-inflammatory, and antiapoptotic activities. The current work examines the various mechanisms through which URO A protects against doxorubicin (DOX)-induced liver injury in Wistar rats. In this experiment, Wistar rats were administered DOX intraperitoneally (20 mg kg-1 ) on day 7 while given URO A intraperitoneally (2.5 or 5 mg kg-1 d-1 ) for 14 days...
April 7, 2023: Biomedicines
https://read.qxmd.com/read/37107354/grape-pomace-as-a-cardiometabolic-health-promoting-ingredient-activity-in-the-intestinal-environment
#23
REVIEW
Diego Taladrid, Miguel Rebollo-Hernanz, Maria A Martin-Cabrejas, M Victoria Moreno-Arribas, Begoña Bartolomé
Grape pomace (GP) is a winemaking by-product particularly rich in (poly)phenols and dietary fiber, which are the main active compounds responsible for its health-promoting effects. These components and their metabolites generated at the intestinal level have been shown to play an important role in promoting health locally and systemically. This review focuses on the potential bioactivities of GP in the intestinal environment, which is the primary site of interaction for food components and their biological activities...
April 21, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/36983053/gut-microbiome-composition-and-its-metabolites-are-a-key-regulating-factor-for-malignant-transformation-metastasis-and-antitumor-immunity
#24
REVIEW
Stefan Lozenov, Boris Krastev, Georgi Nikolaev, Monika Peshevska-Sekulovska, Milena Peruhova, Tsvetelina Velikova
The genetic and metabolomic abundance of the microbiome exemplifies that the microbiome comprises a more extensive set of genes than the entire human genome, which justifies the numerous metabolic and immunological interactions between the gut microbiota, macroorganisms and immune processes. These interactions have local and systemic impacts that can influence the pathological process of carcinogenesis. The latter can be promoted, enhanced or inhibited by the interactions between the microbiota and the host...
March 22, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36891165/-lactiplantibacillus-pentosus-p2020-protects-the-hyperuricemia-and-renal-inflammation-in-mice
#25
JOURNAL ARTICLE
Zhihuan Wang, Liqiong Song, Xianping Li, Yuchun Xiao, Yuanming Huang, Yue Zhang, Jintong Li, Mingding Li, Zhihong Ren
INTRODUCTION: Hyperuricemia (HUA) is a common metabolic disease, and its prevalence has been increasing worldwide. Pharmaceutical drugs have been used for controlling HUA but they all have certain side effects, which thus calls for discovering alternative options including using treatment of probiotics to prevent the development of HUA. METHODS: We established HUA mice model induced by potassium oxonate and adenine and performed in vivo experiments to verify the ability to lower serum uric acid of Lactiplantibacillus pentosus P2020 (LPP), a probiotics stain extracted from Chinese pickle...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/36839287/neuroprotective-effects-of-sodium-butyrate-by-restoring-gut-microbiota-and-inhibiting-tlr4-signaling-in-mice-with-mptp-induced-parkinson-s-disease
#26
JOURNAL ARTICLE
Tong-Tong Guo, Zheng Zhang, Yan Sun, Rui-Yang Zhu, Fei-Xia Wang, Lian-Ju Ma, Lin Jiang, Han-Deng Liu
Parkinson's disease (PD) is a prevalent type of neurodegenerative disease. There is mounting evidence that the gut microbiota is involved in the pathogenesis of PD. Sodium butyrate (NaB) can regulate gut microbiota and improve brain functioning in neurological disorders. Hence, we examined whether the neuroprotective function of NaB on PD was mediated by the modulation of gut microbial dysbiosis and revealed its possible mechanisms. Mice were administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 7 consecutive days to construct the PD model...
February 13, 2023: Nutrients
https://read.qxmd.com/read/36776226/a-review-article-on-neuroprotective-immunomodulatory-and-anti-inflammatory-role-of-vitamin-d3-in-elderly-covid-19-patients
#27
REVIEW
Amit Kumar Tripathi, Sunil Kumar Mishra
Vitamin D3 is a secosteroid, broad-spectrum immunomodulatory, antioxidant, and anti-inflammatory hormone produced either by the internal subcutaneous pathway in the presence of ultraviolet B (UVB) rays or by the external pathway in the form of supplements. Vitamin D3 deficiency is a common and reversible contributor to mortality and morbidity among critically ill patients, including Coronavirus Disease 2019 (COVID-19) and other viral infections. The major functions of vitamin D3 are inhibiting the proinflammatory pathways, including nuclear factor kappa B (NF-kB), inflammatory cytokines, such as interleukin-6 (ILs-6), interleukin-18 (ILs-18), and tumour necrosis factor (TNF), preventing the loss of neural sensation in COVID-19, maintaining respiratory homeostasis, and acting as an antiviral, antimalarial, and antihypertensive agent...
2023: Egyptian Journal of Neurology, Psychiatry and Neurosurgery
https://read.qxmd.com/read/36737950/pingyin-rose-essential-oil-restores-intestinal-barrier-integrity-in-dss-induced-mice-colitis-model
#28
JOURNAL ARTICLE
Rifat Nowshin Raka, Junsong Xiao, Hua Wu, Wenwen Lv, Zhiqian Ding, Yangping Cao, Xukai Li, Jinglong Sun, Kou Luan
Rosa rugosa cv. Plena is a 'drug homologous food' in China with a long history. Pingyin rose essential oil (PREO) is a mixture of compounds extracted from blooming R. rugosa cv. Plena. With its elegant smell and excellent effects on oxidative stress and inflammation alleviation, PREO is wildly used in the food industry as a popular additive. We aimed to decipher if the PREO could alleviate and restore dextran sodium sulfate (DSS)-induced barrier integrity damages. The results showed that a 7-day PREO (15 μL/kg) treatment alleviated the colitis symptoms by improving disease activity index (DAI) scores through weight loss, occult blood, and colon shortening...
February 2023: Food Research International
https://read.qxmd.com/read/36436708/metasilicate-based-alkaline-mineral-water-confers-diarrhea-resistance-in-maternally-separated-piglets-via-the-microbiota-gut-interaction
#29
JOURNAL ARTICLE
Jian Chen, Xiang-Wen Xu, Jian-Xun Kang, Bi-Chen Zhao, Ya-Ru Xu, Jin-Long Li
Stress or stress-induced intestinal disturbances, especially diarrhea, are the main triggers for inflammatory bowel disease and irritable bowel syndrome. Diarrhea and intestinal inflammatory disease afflict patients around the world, and it has become a huge burden on the global health care system. Drinking sodium metasilicate-based alkaline mineral water (SM-based AMW) exerts a potential therapeutic effect in gastrointestinal disorders, including gut inflammation, and diarrhea, but the supportive evidence on animal studies and mechanism involved remain unreported...
November 24, 2022: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/36293528/lipopolysaccharides-lpss-as-potent-neurotoxic-glycolipids-in-alzheimer-s-disease-ad
#30
REVIEW
Yuhai Zhao, Vivian R Jaber, Aileen I Pogue, Nathan M Sharfman, Christopher Taylor, Walter J Lukiw
Lipopolysaccharides (LPSs) are microbiome-derived glycolipids that are among the most potent pro-inflammatory neurotoxins known. In Homo sapiens , the major sources of LPSs are gastrointestinal (GI)-tract-resident facultative anaerobic Gram-negative bacilli, including Bacteroides fragilis and Escherichia coli . LPSs have been abundantly detected in aged human brain by multiple independent research investigators, and an increased abundance of LPSs around and within Alzheimer's disease (AD)-affected neurons has been found...
October 21, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36252894/fecal-microbiota-transplantation-improves-intestinal-inflammation-in-mice-with-ulcerative-colitis-by-modulating-intestinal-flora-composition-and-down-regulating-nf-kb-signaling-pathway
#31
JOURNAL ARTICLE
Dongyue Li, Lanrong Cui, Yanhong Gao, Yang Li, Xin Tan, Hongyu Xu
Ulcerative colitis (UC) is a chronic inflammatory disease of the intestine. It is characterized with recurrent. The pathogenesis is mainly associated with environmental factors, genetic susceptibility, dysbiosis of the intestinal flora and autoimmunity. The role of intestinal flora disorders in the pathogenesis and progression of UC is becoming increasingly prominent. More and more studies have confirmed that fecal microbiota transplantation (FMT) could reshape the composition of UC intestinal flora and it is expected to be a new strategy for UC treatment...
October 14, 2022: Microbial Pathogenesis
https://read.qxmd.com/read/36238377/pear-pomace-alleviated-atopic-dermatitis-in-nc-nga-mice-and-inhibited-lps-induced-inflammation-in-raw-264-7-macrophages
#32
JOURNAL ARTICLE
Mikyoung You, Ziyun Wang, Hwa-Jin Kim, Young-Hyun Lee, Hyeon-A Kim
BACKGROUND/OBJECTIVES: Poorly regulated inflammation is believed to be the most predominant factor that can result in a wide scope of diseases including atopic dermatitis (AD). Despite many studies on the effect of pear pomace in obesity-related disorders including dysregulated gut microbiota, the protective effect of pear pomace in AD is still unknown. This study aimed to evaluate the effect of pear pomace ethanol extract (PPE) on AD by inhibiting inflammation. MATERIALS/METHODS: In the in vivo experiment, 2, 4-dinitrochlorobenzene (DNCB) was applied to NC/Nga mice to induce AD-like skin lesions...
October 2022: Nutrition Research and Practice
https://read.qxmd.com/read/36192578/dysbiotic-microbiota-contributes-to-the-extent-of-acute-myocardial-infarction-in-rats
#33
JOURNAL ARTICLE
Marc-André Gagné, Claude Barbeau, Geneviève Frégeau, Kim Gilbert, Olivier Mathieu, Jérémie Auger, Thomas A Tompkins, Emmanuel Charbonney, Roger Godbout, Guy Rousseau
Increasing evidence suggests that the intestinal microbiota composition could play a role in specific pathologies such as hypertension, obesity and diabetes. This study aims to demonstrate that the intestinal microbiota modulated by a diet creating dysbiosis increased the size of the myocardial infarction and that probiotics could attenuate this effect. To do this, microbiota transplants from rats fed a dysbiotic or non-dysbiotic diet in the presence or absence of probiotics were performed for 10 days on rats whose microbiota had been previously suppressed by antibiotic therapy...
October 3, 2022: Scientific Reports
https://read.qxmd.com/read/36181407/aberrant-branched-chain-amino-acid-accumulation-along-the-microbiota-gut-brain-axis-crucial-targets-affecting-the-occurrence-and-treatment-of-ischaemic-stroke
#34
JOURNAL ARTICLE
Jiajia Shen, Huimin Guo, Shijia Liu, Wei Jin, Zhi-Wei Zhang, Yong Zhang, Keanqi Liu, Shuying Mao, Zhihao Zhou, Lin Xie, Guangji Wang, Haiping Hao, Yan Liang
BACKGROUND AND PURPOSE: Although increasing evidence illustrated that the bidirectional communication between the brain and the gut is closely related to the occurrence of various complex diseases. Limited effort has been made to explore the influence of intestinal flora on the risk of ischaemic stroke. The present study aims to identify microbiota and specialized microbiota metabolites related to the occurrence and treatment of ischaemic stroke. EXPERIMENTAL APPROACH: The role of microbiota in the occurrence and the treatment of ischaemic stroke was evaluated on ischaemia/reperfusion (I/R), pseudo-germ-free and faecal transplantation animals...
February 2023: British Journal of Pharmacology
https://read.qxmd.com/read/36077051/effects-of-two-distinct-psychoactive-microbes-lacticaseibacillus-rhamnosus-jb-1-and-limosilactobacillus-reuteri-6475-on-circulating-and-hippocampal-mrna-in-male-mice
#35
JOURNAL ARTICLE
Sandor Haas-Neill, Eiko Iwashita, Anna Dvorkin-Gheva, Paul Forsythe
Discovery of the microbiota-gut-brain axis has led to proposed microbe-based therapeutic strategies in mental health, including the use of mood-altering bacterial species, termed psychobiotics. However, we still have limited understanding of the key signaling pathways engaged by specific organisms in modulating brain function, and evidence suggests that bacteria with broadly similar neuroactive and immunomodulatory actions can drive different behavioral outcomes. We sought to identify pathways distinguishing two psychoactive bacterial strains that seemingly engage similar gut-brain signaling pathways but have distinct effects on behaviour...
August 25, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36076615/medicinal-uses-pharmacological-activities-phytochemistry-and-the-molecular-mechanisms-of-punica-granatum-l-pomegranate-plant-extracts-a-review
#36
REVIEW
Nhlanhla Maphetu, Jeremiah Oshiomame Unuofin, Nelisiwe Prenate Masuku, Chijioke Olisah, Sogolo Lucky Lebelo
Punica granatum L (pomegranate) is one of the Mediterranean medicinal plants that has been used for generations in treating ulcers, diarrhea, and male infertility. Increasing evidence has revealed that pomegranate possesses myriads of pharmacological activities such as anti-diabetic, anti-tumor, anti-inflammatory, anti-malaria, anti-fibrotic, anti-fungal, anti-bacterial, and other effects. Consumption of pomegranate could be used to improve gut microbiota, and therefore prevent obesity and diabetes. The mechanisms of actions of pomegranate, mainly involve nuclear factor-erythroid factor 2-related factor 2 (Nrf2), nuclear factor kappa B (NF-kB), and mitogen-activated protein kinase (MAPK) signaling pathways...
September 2022: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/35959705/food-for-healthier-aging-power-on-your-plate
#37
JOURNAL ARTICLE
Denise Mafra, Stephanie Ariemu Ugochukwu, Natalia A Borges, Ludmila F M F Cardozo, Peter Stenvinkel, Paul G Shiels
Inflammageing is a persistent low-level inflammatory burden that accompanies age-related dysregulation of the immune system during normative aging and within the diseasome of aging. A healthy diet containing a balanced amount of macronutrients, vitamins and minerals, adequate in calories and rich in poly(phenols), has an essential role in mitigating the effects of inflammageing and extending healthspan through modulation of the activity of a range of factors. These include transcription factors, such as nuclear factor erythroid-derived 2 related factor 2 (Nrf2) and nuclear factor-κB (NF-kB), the inflammasome and the activities of the gut microbiota...
August 12, 2022: Critical Reviews in Food Science and Nutrition
https://read.qxmd.com/read/35955865/impairment-in-the-intestinal-morphology-and-in-the-immunopositivity-of-toll-like-receptor-4-and-other-proteins-in-an-autistic-mouse-model
#38
JOURNAL ARTICLE
Caterina Franco, Marzia Gianò, Gaia Favero, Rita Rezzani
Autism spectrum disorder (ASD) identifies a neurodevelopmental disease defined by social impairments and repetitive or stereotyped behaviors. The etiology of ASD remains unclear; it primarily affects the brain, but a link between gastrointestinal (GI) diseases, inflammatory mucosal pathology and this disorder has been suggested. In particular, a central role seems to be played by an imbalance in pro-and anti-inflammatory cytokines, oxidative stress, and apoptosis. Toll-like receptor 4 (TLR4) is a protein of innate immunity responsible for the regulation and maintenance of intestinal homeostasis...
August 5, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35889822/alginate-oligosaccharides-ameliorate-dss-induced-colitis-through-modulation-of-ampk-nf-%C3%AE%C2%BAb-pathway-and-intestinal-microbiota
#39
JOURNAL ARTICLE
Yue Zhang, Congcong Guo, Yanru Li, Xianlei Han, Xuegang Luo, Liehuan Chen, Tongcun Zhang, Nan Wang, Weiming Wang
Alginate oligosaccharides (AOS) are shown to have various biological activities of great value to medicine, food, and agriculture. However, little information is available about their beneficial effects and mechanisms on ulcerative colitis. In this study, AOS with a polymerization degree between 2 and 4 were found to possess anti-inflammatory effects in vitro and in vivo. AOS could decrease the levels of nitric oxide (NO), IL-1β, IL-6, and TNFα, and upregulate the levels of IL-10 in both RAW 264.7 and bone-marrow-derived macrophage (BMDM) cells under lipopolysaccharide (LPS) stimulation...
July 13, 2022: Nutrients
https://read.qxmd.com/read/35866029/poloxamer-407-and-hyaluronic-acid-thermosensitive-hydrogel-encapsulated-ginsenoside-rg3-to-promote-skin-wound-healing
#40
JOURNAL ARTICLE
Xiaojuan Peng, Chuanbo Ding, Yingchun Zhao, Mingqian Hao, Wencong Liu, Min Yang, Fengyan Xiao, Yinan Zheng
Ginsenoside Rg3 has shown beneficial effects in various skin diseases. The current interest in designing and developing hydrogels for biomedical applications continues to grow, inspiring the further development of drug-loaded hydrogels for tissue repair and localized drug delivery. The aim of the present study was to develop an effective and safe hydrogel (Rg3-Gel), using ginsenoside Rg3, and we evaluated the wound-healing potential and therapeutic mechanism of Rg3-Gel. The results indicated that the optimized Rg3-Gel underwent discontinuous phase transition at low and high temperatures...
2022: Frontiers in Bioengineering and Biotechnology
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