Ahmed M El-Baz, Amira M El-Ganiny, Doaa Hellal, Hala M Anwer, Hend A Abd El-Aziz, Ibrahim E Tharwat, Mohamed A El-Adawy, Shehab El-Din M Helal, Menna Tallah A Mohamed, Tassnim M Azb, Hanya M Elshafaey, AbdulRahman A Shalata, Sahar M Elmeligi, Noran H Abdelbary, Attalla F El-Kott, Fatimah A Al-Saeed, Eman T Salem, Mohamed M Adel El-Sokkary, Ahmed Shata, Ahmed A Shabaan
Non-alcoholic steatohepatitis (NASH) is a more dangerous form of chronic non-alcoholic fatty liver disease (NAFLD). In the current investigation, the influence of citicoline on high-fat diet (HFD)-induced NASH was examined, both alone and in combination with Lactobacillus (probiotic). NASH was induced by feeding HFD (10% sugar, 10% lard stearin, 2% cholesterol, and 0.5% cholic acid) to rats for 13 weeks and received single i.p. injection of streptozotocin (STZ, 30 mg/kg) after 4 weeks. Citicoline was given at two dose levels (250 mg and 500 mg, i...
June 8, 2023: AMB Express