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"Growth restriction"

Graciane Petre, Patrick Lorès, Hervé Sartelet, Aurélie Truffot, Brice Poreau, Sandrine Brandeis, Guillaume Martinez, Véronique Satre, Radu Harbuz, Pierre F Ray, Florence Amblard, Françoise Devillard, Gaëlle Vieville, Francois Berger, Pierre-Simon Jouk, Daniel Vaiman, Aminata Touré, Charles Coutton, Marie Bidart
We report findings from a male fetus of 26 weeks' gestational age with severe isolated intrauterine growth restriction (IUGR). Chromosomal microarray analysis (CMA) on amniotic fluid cells revealed a 1.06-Mb duplication in 19q13.42 inherited from the healthy father. This duplication contains 34 genes including ZNF331, a gene encoding a zinc-finger protein specifically imprinted (paternally expressed) in the placenta. Study of the ZNF331 promoter by methylation-specific-multiplex ligation-dependent probe amplification (MS-MLPA) showed that the duplicated allele was not methylated in the fetus unlike in the father's genome, suggesting both copies of the ZNF331 gene are expressed in the fetus...
September 16, 2018: Clinical Genetics
Katie N Murray, Michelle E Edye, Maurizio Manca, Anthony C Vernon, Joanna M Oladipo, Victoria Fasolino, Michael K Harte, Varsha Mason, Ben Grayson, Patrick C McHugh, Irene Knuesel, Eric P Prinssen, Reinmar Hager, Joanna C Neill
Maternal immune activation (mIA) in rodents is rapidly emerging as a key model for neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. Here, we optimise a mIA model in rats, aiming to address certain limitations of current work in this area. Specifically, the lack of clear evidence for methodology chosen, identification of successful induction of mIA in the dams and investigation of male offspring only. We focus on gestational and early juvenile changes in offspring following mIA as detailed information on these critical early developmental time points is sparse...
September 12, 2018: Brain, Behavior, and Immunity
Juncao Chen, Xiaoyun Gong, Li Huang, Pingyang Chen, Tao Wang, Wei Zhou, Kaiju Luo, Jing Wang
In humans, malnutrition during pregnancy results in intrauterine growth restriction (IUGR) and an increased risk of neurological morbidities; altered miRNA characteristics have been suggested to contribute to IUGR neurological pathogenesis. A miRNA microarray was used to identify differentially expressed miRNA molecules in the hippocampi of rats with IUGR. Five of the molecules in question were selectively validated using real-time PCR in rats with IUGR. We then investigated the role of miR-199a-5p in hippocampal pathology...
September 14, 2018: Scientific Reports
Ebba Alkhunaizi, Ranad Shaheen, Sanjay Kumar Bharti, Ann M Joseph-George, Karen Chong, Ghada M H Abdel-Salam, Mohammed Alowain, Susan I Blaser, Blake C Papsin, Mohammed Butt, Mais Hashem, Nicole Martin, Ruth Godoy, Robert M Brosh, Fowzan S Alkuraya, David Chitayat
Warsaw breakage syndrome (WBS) is a recently recognized DDX11-related rare cohesinopathy, characterized by severe prenatal and postnatal growth restriction, microcephaly, developmental delay, cochlear anomalies, and sensorineural hearing loss. Only seven cases have been reported in the English literature, and thus the information on the phenotype and genotype of this interesting condition is limited. We provide clinical and molecular information on five additional unrelated patients carrying novel bi-allelic variants in the DDX11 gene, identified via whole exome sequencing...
September 14, 2018: American Journal of Medical Genetics. Part A
Neha Daga, Simone Eicher, Abhilash Kannan, Alain Casanova, Shyan H Low, Saskia Kreibich, Daniel Andritschke, Mario Emmenlauer, Jeremy L Jenkins, Wolf-Dietrich Hardt, Urs F Greber, Christoph Dehio, Christian von Mering
Perturbation of gene expression by means of synthetic small interfering RNAs (siRNAs) is a powerful way to uncover gene function. However, siRNA technology suffers from sequence-specific off-target effects and from limitations in knock-down efficiency. In this study, we assess a further problem: unintended effects of siRNA transfections on cellular fitness/proliferation. We show that the nucleotide compositions of siRNAs at specific positions have reproducible growth-restricting effects on mammalian cells in culture...
September 12, 2018: Nucleic Acids Research
C-J Arthuis, V Mendes, S Même, W Même, C Rousselot, N Winer, A Novell, F Perrotin
INTRODUCTION: Exploration of placental perfusion is essential in screening for dysfunctions impairing fetal growth. The objective of this study was to assess the potential value of contrast-enhanced ultrasonography (CEUS) and magnetic resonance imaging (MRI) for examining placental perfusion in a murine model of intrauterine growth restriction (IUGR). We also studied the reproducibility of perfusion quantification by CEUS. METHODS: Pregnant Sprague Dawley rat models of IUGR were studied during the third trimester...
September 2018: Placenta
Le Fu, Jun Zhang, Shiyi Xiong, Minghua Sun
OBJECTIVES: The apparent diffusion coefficient (ADC) was associated with the onset of intrauterine growth restriction in singleton pregnancies. However, the correlation of ADC with selective intrauterine growth restriction (sIUGR) of monochorionic (MC) twin pregnancies remained unknown. In this study, we aimed to evaluate the association of ADC with sIUGR in MC twin pregnancies by exploring diffusion weighted MR imaging (DWI). METHODS: Fifty-one MC twin pregnancies, consisting 19 cases of sIUGR and 32 cases without sIUGR, were re-analyzed by DWI...
September 2018: Placenta
Yimeng Xia, Xin Ma, Brian B Griffiths, Yan Luo
RATIONALE: Being required to perform neurosurgery on a pregnant woman is rare, but occasionally unavoidable. In these cases, clinical anesthesiologists are confronted with conflicting information and few evidence-based guidelines. PATIENT CONCERNS: Here, we describe the successful anesthetic management of a 24-week pregnant woman with macroprolactinoma who underwent endonasal transsphenoidal resection of pituitary adenoma. DIAGNOSES: According to the prolactin (PRL) level and magnetic resonance imaging (MRI) results, the patient was diagnosed with macroprolactinoma and kept stable after taking the regular bromocriptine treatment...
September 2018: Medicine (Baltimore)
Li Ni, Yibin Pan, Chao Tang, Wenyi Xiong, Ximei Wu, Chaochun Zou
Antenatal overexposure to glucocorticoids causes fetal intrauterine growth restriction (IUGR) and adult metabolic disorders. 11β-hydroxysteroid dehydrogenase (11β-HSD) 1 and 2 are key enzymes for glucocorticoid metabolism, however, the detailed effects of antenatal overexposure to glucocorticoids on placental 11β-HSD1 and 2 expression and adult metabolic disorders remain obscure. Here, we report that, in placenta 11β-HSD1 is diffusely localized, whereas 11β-HSD2 is specifically expressed in labyrinthine layer...
2018: PloS One
Cecilia Villalaín, Ignacio Herraiz, Maria S Quezada, Paula I Gómez-Arriaga, Elisa Simón, Enery Gómez-Montes, Alberto Galindo
Objectives As conflicting results have been reported about the association of reversed flow on the aortic isthmus (AoI) and adverse perinatal results in fetal growth restriction (FGR), we aim to compare perinatal outcomes (including tolerance to labor induction) of late-onset FGR between those with anterograde and reversed AoI flow. Methods This was an observational retrospective cohort study on 148 singleton gestations diagnosed with late-onset FGR (diagnosis ≥32+0 weeks), with an estimated fetal weight (EFW) <10th centile and mild fetal Doppler alteration: umbilical artery (UA) pulsatility index (PI) >95th centile, middle cerebral artery (MCA)-PI <5th centile or cerebral-placental ratio <5th centile...
September 13, 2018: Journal of Perinatal Medicine
Patrícia P Silveira, Irina Pokhvisneva, Hélène Gaudreau, Anne Rifkin-Graboi, Birit F P Broekman, Meir Steiner, Robert Levitan, Carine Parent, Josie Diorio, Michael J Meaney
Individuals born after intrauterine growth restriction (IUGR) are more impulsive towards palatable foods, but it is not clear 1) if IUGR-related impulsivity is specific for foods and solely based on response inhibition and 2) if the development of impulsivity is due to being born IUGR per se or to growing up fast in the first few years of life (catch up growth). Children were classified in the IUGR group if the birth weight ratio was below 0.85. Delta z score for BMI was used as a measure of catch up growth...
September 12, 2018: Scientific Reports
Ruofan Yao, Stephen A Contag, Katherine R Goetzinger, Sarah D Crimmins, Jerome N Kopelman, Sifa Turan, Ozhan M Turan
OBJECTIVE: Down syndrome (DS) is associated with significant risk of perinatal mortality. We hypothesize that this association is primarily mediated through the effects of fetal growth restriction (FGR). METHODS: This was a retrospective cohort analysis using the US Natality Database from 2011 to 2013. Analysis was limited to singleton nonanomalous pregnancies or confirmed DS pregnancies without severe structural anomalies between 24 and 42 w in gestation. The risk of stillbirth (SB) associated with DS was estimated using both Cox proportional Hazard (HR) regression and accelerated failure time (AFT) methods...
September 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
Francesca M Russo, Sigrid Conings, Karel Allegaert, Tim van Mieghem, Jaan Toelen, Kristel van Calsteren, Pieter Annaert, Jan Deprest
BACKGROUND: Sildenafil is already administered during gestation in patients with pulmonary hypertension and is under evaluation as a treatment for several pregnancy complications, such as pre-eclampsia and intrauterine growth restriction. Animal studies have shown a potential therapeutic effect of the drug in fetuses with congenital diaphragmatic hernia, rescuing peripheral pulmonary vasculature and airway phenotype. When considering this drug for evaluation in a clinical trial, data on effective human placental drug passage are required...
September 4, 2018: American Journal of Obstetrics and Gynecology
Henning Feist, Gitta Turowski, Kais Hussein, Thordis Blöcker, Albert Heim
Massive perivillous fibrin deposition (MFD) is a morphologically defined severe placental lesion associated with perinatal morbidity and mortality. The etiology is unknown, and recurrence risk in subsequent pregnancies is assumed to be high. In most cases, a pathologic immune reaction is supposed to be responsible for the lesion. We report a case of a pregnant woman's suffering from hand, foot, and mouth disease in the 20th gestational week. Subsequently, MFD developed in the placenta and was followed by intrauterine growth restriction and stillbirth in the 29th gestational week...
September 7, 2018: Pediatric and Developmental Pathology
Whitney Bender, Adi Hirshberg, Lisa D Levine
OBJECTIVE:  To examine the change in body mass index (BMI) categories between pregnancies and its effect on adverse pregnancy outcomes. STUDY DESIGN:  We performed a retrospective cohort study of women with two consecutive deliveries from 2005 to 2010. Analysis was limited to women with BMI recorded at <24 weeks for both pregnancies. Standard BMI categories were used. Adverse pregnancy outcomes included preterm birth at <37 weeks, intrauterine growth restriction (IUGR), pregnancy-related hypertension, and gestational diabetes mellitus (GDM)...
September 7, 2018: American Journal of Perinatology
Scott A Booth, Glenn D Wadley, Francine Z Marques, Mary E Wlodek, Fadi J Charchar
BACKGROUND AND AIMS: Fetal and postnatal growth restriction predispose to cardiovascular disease (CVD) in adulthood. Telomeres are repetitive DNA-protein structures that protect chromosome ends, and the loss of these repeats (a reduction in telomere length) is associated with CVD. As exercise preserves telomere length and cardiovascular health, the aim of this study was to determine the effects of growth restriction and exercise training on cardiac telomere length and telomeric genes...
September 7, 2018: Physiological Genomics
Fulesh Kunwar, Rebecca Pabst, Sonal Bakshi
BACKGROUND: Uniparental disomy (UPD) is a condition where both the chromosomes are inherited from the same parent. The consequences of UPD can be ranging from normal to congenital anomaly depending on the parental origin and chromosome involved. Case characteristics: Here, we describe a case of 2-year-old male with central hypotonia, torticollis, and delayed motor skills born to a nonconsanguineous healthy parent. The proband was prenatally detected with paternal isodisomy 5 and birth was induced at 38 weeks of gestation due to intrauterine growth restriction...
September 6, 2018: Journal of Maternal-fetal & Neonatal Medicine
Ioannis Papastefanou, Charalambos Chrelias, Charalambos Siristatidis, Dimitra Kappou, Makarios Eleftheriades, Dimitrios Kassanos
OBJECTIVE: to evaluate the predictive value of first trimester placental volume in pregnancies destined to develop fetal growth restriction (FGR) and preeclampsia (PE). METHODS: Prospective observational study including placentas from 34 FGR, 12 PE, 15 GH (gestational hypertension) pregnancies and 265 controls. Placental volume (PV) was obtained using VOCAL technique and a z-score was calculated (z-PV). The association of PV with other first trimester variables and maternal characteristics was assessed with Spearman's correlation...
September 6, 2018: Prenatal Diagnosis
Teresa Tropea, Mark Wareing, Susan L Greenwood, Martin Feelisch, Colin P Sibley, Elizabeth C Cottrell
Adequate perfusion of the placental vasculature is essential to meet the metabolic demands of fetal growth and development. Lacking neural control, local tissue metabolites, circulating and physical factors contribute significantly to blood flow regulation. Nitric oxide (NO) is a key regulator of fetoplacental vascular tone. Nitrite, previously considered an inert end-product of NO oxidation, has been shown to provide an important source of NO. Reduction of nitrite to NO may be particularly relevant in tissue when the oxygen-dependent NO synthase (NOS) activity is compromised, e...
September 1, 2018: Nitric Oxide: Biology and Chemistry
Lucy Neave, Marie Scully
Thrombotic microangiopathies (TMAs) are associated with microangiopathic hemolytic anemia and thrombocytopenia, resulting in microvascular thrombosis and end-organ damage. In pregnancy, this may be the result of pregnancy-related TMAs such as preeclampsia; hemolysis, elevated liver enzymes, and low platelets; or pregnancy-associated TMAs, specifically thrombotic thrombocytopenic purpura (TTP) or complement-mediated hemolytic uremic syndrome (CM HUS). TTP and CM HUS are rare disorders, and their diagnosis may be missed, no less because features at presentation may be misdiagnosed as a pregnancy-related TMA, such as hypertension, proteinuria, fetal growth restriction, or in utero fetal death...
August 18, 2018: Transfusion Medicine Reviews
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