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https://www.readbyqxmd.com/read/28917582/preterm-pre-eclampsia-what-every-neonatologist-should-know
#1
REVIEW
Lisa Story, Lucy C Chappell
Although pre-eclampsia affects 5-10% of pregnancies globally and is responsible for substantial maternal and perinatal morbidity and mortality, currently there is no cure other than delivery of the baby. Predictive screening tests based on clinical risk factors, with or without the addition of biomarkers and imaging, have been developed, but adoption into clinical practice is limited by suboptimal test performance. Once established pre-eclampsia is diagnosed, a woman is usually managed expectantly prior to 37weeks' gestation to reduce perinatal morbidity and mortality associated with iatrogenic prematurity until maternal or fetal triggers for delivery mean that risks of pregnancy prolongation outweigh the benefits...
September 13, 2017: Early Human Development
https://www.readbyqxmd.com/read/28915160/current-insights-in-obstetric-antiphospholipid-syndrome
#2
Karen Schreiber, Massimo Radin, Savino Sciascia
PURPOSE OF REVIEW: Antiphospholipid syndrome (APS) is defined as the association of thrombotic events and/or obstetric morbidity in patients persistently positive for antiphospholipid antibodies (aPL). In this review, we will highlight the most important clinical presentations of APS with a focus on the obstetric morbidity, the current management strategies and the outlook for the future. RECENT FINDINGS: The use of aspirin and heparin has improved the pregnancy outcome in obstetric APS and approximately 70% of pregnant women with APS have a successful pregnancy outcome...
September 14, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28911926/severe-ovarian-hyperstimulation-syndrome-modifies-early-maternal-serum-beta-human-chorionic-gonadotropin-kinetics-but-obstetrical-and-neonatal-outcomes-are-not-impacted
#3
Cécile Choux, Julie Barberet, Perrine Ginod, Jonathan Cottenet, Céline Bruno, Eric Benzénine, Paul Sagot, Patricia Fauque
OBJECTIVE: To study the impact of severe ovarian hyperstimulation syndrome (OHSS) on beta-hCG kinetics and obstetrical and neonatal outcomes. DESIGN: Retrospective single-center case-control study. SETTING: University tertiary referral center. PATIENT(S): A total of 77 patients who presented a clinical pregnancy after IVF and had been hospitalized for severe OHSS were included in this study and compared with 231 controls presenting an IVF-induced clinical pregnancy without OHSS and matched for the year of pregnancy and the number of gestational sacs...
September 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28904937/effect-of-magnesium-supplement-on-pregnancy-outcomes-a-randomized-control-trial
#4
Elaheh Zarean, Amal Tarjan
BACKGROUND: Magnesium (Mg) is an essential mineral required to regulate body temperature, nucleic acid, and protein synthesis with an important role in maintaining nerve and muscle cell electrical potentials. It may reduce fetal growth restriction and preeclampsia as well as increase birth weight. This study aimed to assess the effects of consuming Mg supplementation during pregnancy on pregnancy outcomes. MATERIALS AND METHODS: This is a randomized controlled trial with three sixty populated groups of pregnant women...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28901463/microrna-expression-profiles-and-networks-in-placentas-complicated-with-selective-intrauterine-growth-restriction
#5
Hong Wen, Lu Chen, Jing He, Jun Lin
The microRNA (miRNA) profiles of placentas complicated with selective intrauterine growth restriction (sIUGR) are unknown. In the present study, the sIUGR‑associated placental miRNA expression was investigated using microarray and confirmatory reverse transcriptase‑quantitative polymerase chain reaction studies. Placenta samples around the individual insertion region for each umbilical cord were collected from monochorionic twins complicated with (n=17) or without sIUGR (control, n=16). miRNA profile analysis was performed on two sIUGR cases and one control using an Affymetrix microRNA 4...
September 11, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900802/assessment-of-m2-anxa5-haplotype-as-a-risk-factor-in-couples-with-placenta-mediated-pregnancy-complications
#6
Nina Rogenhofer, Lara R M Nienaber, Lea C Amshoff, Nadia Bogdanova, David Petroff, Peter Wieacker, Christian J Thaler, Arseni Markoff
PURPOSE: The aim of this study was to confirm the associated M2/ANXA5 carrier risk in women with placenta-mediated pregnancy complications (PMPC) and to test their male partners for such association. Further analysis evaluated the influence of maternal vs. paternal M2 alleles on miscarriage. METHODS: Two hundred eighty-eight couples with preeclampsia (PE), intrauterine growth restriction (IUGR), or premature birth (PB) were recruited (n = 96 of each phenotype)...
September 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28900713/complement-activation-a-threat-to-pregnancy
#7
REVIEW
Guillermina Girardi
Pregnancy poses a challenge for the immune systems of placental mammals. As fetal tissues are semi-allogeneic and alloantibodies that commonly develop in the mother, the fetus and the placenta might be subject to complement-mediated immune attack with the potential risk of adverse pregnancy outcomes. Here, I describe how the use of animal models was pivotal in demonstrating that complement inhibition at the fetomaternal interface is essential for a successful pregnancy. Studies in animals also helped the identification of uncontrolled complement activation as a crucial effector in the pathogenesis of recurrent miscarriages, intrauterine growth restriction, preeclampsia, and preterm birth...
September 12, 2017: Seminars in Immunopathology
https://www.readbyqxmd.com/read/28899619/first-do-the-experiment-do-computerised-interpretation-of-cardiotocography-and-other-widely-used-interventions-improve-newborn-outcomes
#8
REVIEW
Philip Steer
The introduction of continuous electronic fetal heart rate monitoring (EFM) in labour has coincided with a steady and remarkable fall in perinatal mortality. Whether this is cause or coincidence remains unclear because randomised trials have been underpowered. Attempts to improve the sensitivity and specificity of fetal compromise detection using fetal blood sampling and pH measurement, pulse oximetry, and fetal electrocardiogram analysis have failed to provide evidence of additional value in randomised trials...
September 9, 2017: Early Human Development
https://www.readbyqxmd.com/read/28898865/automatic-measurement-of-fetal-brain-development-from-magnetic-resonance-imaging-new-reference-data
#9
Daphna Link, Michael B Braginsky, Leo Joskowicz, Liat Ben Sira, Shaul Harel, Ariel Many, Ricardo Tarrasch, Gustavo Malinger, Moran Artzi, Cassandra Kapoor, Elka Miller, Dafna Ben Bashat
BACKGROUND: Accurate fetal brain volume estimation is of paramount importance in evaluating fetal development. The aim of this study was to develop an automatic method for fetal brain segmentation from magnetic resonance imaging (MRI) data, and to create for the first time a normal volumetric growth chart based on a large cohort. SUBJECTS AND METHODS: A semi-automatic segmentation method based on Seeded Region Growing algorithm was developed and applied to MRI data of 199 typically developed fetuses between 18 and 37 weeks' gestation...
September 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28898404/high-versus-standard-volume-enteral-feeds-to-promote-growth-in-preterm-or-low-birth-weight-infants
#10
REVIEW
Thangaraj Abiramalatha, Niranjan Thomas, Vijay Gupta, Anand Viswanathan, William McGuire
BACKGROUND: Breast milk alone, given at standard recommended volumes (150 to 180 mL/kg/d), is not adequate to meet the protein, energy, and other nutrient requirements of growing preterm or low birth weight infants. One strategy that may be used to address these potential nutrient deficits is to give infants enteral feeds in excess of 200 mL/kg/d ('high-volume' feeds). This approach may increase nutrient uptake and growth rates, but concerns include that high-volume enteral feeds may cause feed intolerance, gastro-oesophageal reflux, aspiration pneumonia, necrotising enterocolitis, or complications related to fluid overload, including patent ductus arteriosus and bronchopulmonary dysplasia...
September 12, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28895695/bronchopulmonary-dysplasia-incidence-and-risk-factors
#11
Pablo H Brener Dik, Yeimy M Niño Gualdron, María F Galletti, Carolina M Cribioli, Gonzalo L Mariani
INTRODUCTION: Bronchopulmonary dysplasia is the most common chronic pulmonary sequela among very low birth weight infants. The objective of this study was to estimate its incidence in our Neonatal Unit over the past 5 years and analyze associated risk factors. POPULATION AND METHODS: An observational and analytical study was conducted in a retrospective cohort, using data obtained from a prospective database of infants born at Hospital Italiano de Buenos Aires with a birth weight of less than 1500 grams between January 2010 and December 2014...
October 1, 2017: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/28893896/sildenafil-during-pregnancy-a-preclinical-meta-analysis-on-fetal-growth-and-maternal-blood-pressure
#12
Nina D Paauw, Fieke Terstappen, Wessel Ganzevoort, Jaap A Joles, Hendrik Gremmels, A Titia Lely
Sildenafil is a new approach to treat fetal growth restriction (FGR) and preeclampsia. We performed a systematic meta-analysis to evaluate effects of sildenafil. Our search identified 22 animal studies (mouse, rat, rabbit, sheep, and guinea pigs) and 2 human randomized controlled trials. Data were pooled using ratio of means and mean differences with 95% confidence intervals for fetal growth and maternal blood pressure, respectively. Meta-regression analyses were performed for study-related factors that might affect efficacy of sildenafil, including the model used (healthy pregnancy versus FGR/preeclampsia) and route of administration...
September 11, 2017: Hypertension
https://www.readbyqxmd.com/read/28893687/genetic-analysis-of-id1-dbl2x-predicts-its-validity-as-a-vaccine-candidate-in-colombia-and-supports-at-least-two-independently-introduced-plasmodium-falciparum-populations-in-the-region
#13
J Rajwani, C M Klinger, E Arango, M I Arroyo, A Sabbagh, A Maestre, J B Dacks, S Gnidehou, S K Yanow
Pregnancy-associated malaria (PAM) poses a threat to both the mother and fetus, increasing the risk of severe maternal anemia, fetal growth restriction and low birth weight infants. Two vaccines are currently in development to protect women from Plasmodium falciparum in pregnancy. Both vaccine constructs target the ID1-DBL2Xb domain of VAR2CSA, a protein expressed on the surface of infected erythrocytes (IEs) that mediates parasite sequestration in the placenta. Although development of an effective vaccine may be hampered by ID1-DBL2Xb polymorphisms expressed by field isolates, a recent study showed that genetic variation of this domain in South American parasite populations is much lower than in other geographical locations...
September 8, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28892981/effect-of-transdermal-nitroglycerine-on-doppler-velocity-waveforms-of-the-uterine-umbilical-and-fetal-middle-cerebral-arteries-in-patients-with-chronic-placental-insufficiency-a-prospective-rct
#14
Suruchi Gupta, Meenakshi Chauhan, Jyotsna Sen, Smiti Nanda
INTRODUCTION: Increase in Nitric Oxide (NO) may be important in vascular adaptation needed to accommodate increased uteroplacental blood flow as pregnancy advances. Hence, in certain conditions like Pregnancy Induced Hypertension (PIH) and Fetal Growth Restriction (FGR), NO donors may play an effective role in increasing uteroplacental perfusion. Transdermal route appears to be a safe and effective route. AIM: To evaluate the effect of nitroglycerine patch on Doppler velocity waveforms of the uterine, umbilical and fetal middle cerebral arteries in patients with chronic placental insufficiency...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892225/expectant-management-of-pregnancies-complicated-by-fetal-growth-restriction-without-any-evidence-of-placental-dysfunction-at-term-comparison-with-routine-labor-induction
#15
Nobuhiro Hidaka, Yuka Sato, Saki Kido, Yasuyuki Fujita, Kiyoko Kato
AIM: To assess the feasibility and practicality of expectant management for pregnancies with fetal growth restriction (FGR) at term without evidence of placental dysfunction. METHODS: We reviewed the records of pregnancies with an estimated fetal weight ≤ 1.5 SD below the mean at 37 weeks of gestation. We excluded elective cesarean deliveries and pregnancies that, at 37 weeks, were complicated by oligohydramnios, decreased fetal cerebroplacental ratio, or pregnancy-related hypertensive disorders...
September 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28890678/pregnancy-following-laparoscopic-hysteropexy-a-case-series
#16
Helen Jefferis, Natalia Price, Simon Jackson
BACKGROUND: Uterine-preserving prolapse surgery offers the chance to retain fertility; however, limited data is available for the safety of pregnancy following surgery and the effect of pregnancy on surgical outcome. Our operative technique involves mesh encircling the cervix and uterine arteries, which raises concerns that compromise of uterine blood flow during pregnancy may lead to foetal growth restriction. We also think this necessitates delivery by caesarean section. We report on six pregnancy outcomes following laparoscopic hysteropexy...
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/28889777/assessment-of-neonatal-adrenal-size-using-high-resolution-2d-ultrasound-and-its-correlation-with-birth-demographics-clinical-outcomes
#17
Tijen Karsli, Diana Strickland, Jeffrey Livingston, Qiang Wu, Maroun J Mhanna, Prem S Shekhawat
OBJECTIVE: Assessment of adrenal function in a sick neonate remains a challenge in spite of major advances in neonatal care. We used 2D ultrasound of adrenal glands to assess maturity of adrenal glands in extremely preterm infants and sick term and near term infants. STUDY DESIGN: We collected demographics details of 99 mother-infants pairs (24-41 weeks) and obtained 2D ultrasound scans of adrenal glands in first week of life to measure adrenal volume, fetal zone size and adrenal to kidney ratios...
September 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28889772/human-papillomavirus-infection-and-intrauterine-growth-restriction-a-data-linkage-study
#18
Judith Helen Ford, Ming Li, Wendy Scheil, David Roder
OBJECTIVE: Using unbiased population data, to examine whether having a positive Pap smear, and thus a high probability of Human Papilloma Virus (HPV) infection, is a significant risk factor for intrauterine growth restriction (IUGR) in a subsequent pregnancy. STUDY DESIGN AND METHODS: Two independent population-based databases, namely the South Australian Perinatal Statistics Collection and the South Australian Cervical Screening Database, were deidentified and linked by the SANT Datalinkage Service...
September 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28889770/angiogenic-factors-for-prediction-of-preeclampsia-and-intrauterine-growth-restriction-onset-in-high-risk-women-angiopred-study
#19
Tiphaine Raia-Barjat, Carole Prieux, Jean-Christophe Gris, Céline Chapelle, Silvy Laporte, Céline Chauleur
OBJECTIVE: The study aimed to compare the level of two angiogenic factors, soluble fms-like tyrosine kinase-1 (sFlt1) and soluble endoglin (sEng), for the prediction of preeclampsia and intrauterine growth restriction in high-risk pregnant women. METHODS: A prospective multicenter cohort study of 200 pregnant patients was conducted between June 2008 and October 2010. sFlt1 and sEng, were measured by enzyme-linked immunosorbent assay. RESULTS: Forty-five patients developed a placenta-mediated adverse pregnancy outcome...
September 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28889126/chromosomal-microarray-analysis-in-fetuses-with-growth-restriction-and-normal-karyotype-a-systematic-review-and-meta-analysis
#20
Antoni Borrell, Maribel Grande, Montse Pauta, Laia Rodriguez-Revenga, Francesc Figueras
OBJECTIVE: To perform a systematic review of the literature and a meta-analysis to estimate the incremental yield of chromosomal microarray analysis (CMA) over karyotyping in fetal growth restriction (FGR). METHODS: This was a systematic review conducted in accordance with the PRISMA criteria. All articles identified in PubMed, Ovid Medline, and ISI Web of Knowledge (Web of Science) from January 2009 to November 2016 describing pathogenic copy number variants (CNVs) in fetuses with growth restriction were included...
September 9, 2017: Fetal Diagnosis and Therapy
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