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https://www.readbyqxmd.com/read/30423589/fetal-abdominal-aorta-doppler-and-structural-evaluation-of-endothelial-function-in-intrauterine-growth-restriction-and-controls
#1
Silvia Visentin, Ambrogio P Londero, Maria Calanducci, Enrico Grisan, Maria Caterina Bongiorno, Loris Marin, Erich Cosmi
No abstract text is available yet for this article.
November 13, 2018: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/30419602/neonatal-outcomes-of-pregnancy-associated-breast-cancer-population-based-study-on-11-million-births
#2
Gil Shechter Maor, Nicholas Czuzoj-Shulman, Andrea R Spence, Haim Arie Abenhaim
BACKGROUND: As the age at first pregnancy continues to rise in the United States so does the incidence of breast cancer diagnosed during pregnancy. Our objective was to evaluate temporal trends in the incidence of pregnancy-associated breast cancer (PABC) and to measure neonatal outcomes associated with PABC. METHODS: We conducted a population-based cohort study using the 1999-2012 Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (HCUP-NIS) from the United States...
November 12, 2018: Breast Journal
https://www.readbyqxmd.com/read/30415741/placental-characteristics-in-monochorionic-twins-with-selective-intrauterine-growth-restriction-in-relation-to-the-umbilical-artery-doppler-classification
#3
S G Groene, L S A Tollenaar, F Slaghekke, J M Middeldorp, M Haak, D Oepkes, E Lopriore
INTRODUCTION: The objective of this study was to evaluate the placental characteristics of monochorionic twin pregnancies with selective intrauterine growth restriction (sIUGR) classified according to the Gratacós classification based on umbilical artery Doppler measurements. METHODS: All consecutive placentas from monochorionic twin pregnancies with sIUGR, (defined as a birthweight discordance > 25% and/or an estimated fetal weight in one twin <10th centile) examined between May 2002 and February 2018 were included in the study...
November 2018: Placenta
https://www.readbyqxmd.com/read/30411435/persistent-amnion-chorion-membrane-separation
#4
Kristin D Gerson, Anna M Modest, Jonathan L Hecht, Brett C Young
AIM: Fetal membranes are composed of the amnion and chorion, which fuse during the early second trimester. Persistent separation confers increased risk of adverse perinatal outcomes. This study characterizes sonographic and placental findings associated with persistent amnion-chorion (AC) membrane separation. METHODS: This is a case series of 23 patients carrying singleton pregnancies with persistent AC membrane separation after 16 weeks' gestation diagnosed by ultrasound from 2010 to 2016 at our institution...
November 8, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/30409992/altered-placental-chorionic-arterial-biomechanical-properties-during-intrauterine-growth-restriction
#5
Shier Nee Saw, Jess Jia Hwee Tay, Yu Wei Poh, Liying Yang, Wei Ching Tan, Lay Kok Tan, Alys Clark, Arijit Biswas, Citra Nurfarah Zaini Mattar, Choon Hwai Yap
Intrauterine growth restriction (IUGR) is a pregnancy complication due to placental dysfunction that prevents the fetus from obtaining enough oxygen and nutrients, leading to serious mortality and morbidity risks. There is no treatment for IUGR despite having a prevalence of 3% in developed countries, giving rise to an urgency to improve our understanding of the disease. Applying biomechanics investigation on IUGR placental tissues can give important new insights. We performed pressure-diameter mechanical testing of placental chorionic arteries and found that in severe IUGR cases (RI > 90th centile) but not in IUGR cases (RI < 90th centile), vascular distensibility was significantly increased from normal...
November 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30408071/impact-of-vitamin-d-and-vitamin-d-receptor-on-the-trophoblast-survival-capacity-in-preeclampsia
#6
Martina Hutabarat, Noroyono Wibowo, Barbara Obermayer-Pietsch, Berthold Huppertz
BACKGROUND: Preeclampsia and intra-uterine growth restriction (IUGR) are major health problems during pregnancy affecting both mother and child. Defective placental development and failure of trophoblast differentiation during pregnancy are important aspects in the pathogenesis of both syndromes. Recent studies have shown that autophagy is involved in the trophoblast survival capacity. As vitamin D has a central role in many cellular processes, we studied the relation of vitamin D and autophagy in those processes of preeclampsia and IUGR...
2018: PloS One
https://www.readbyqxmd.com/read/30407510/the-impact-of-periconceptional-maternal-lifestyle-on-clinical-features-and-biomarkers-of-placental-development-and-function-a-systematic-review
#7
Ignatia F Reijnders, Annemarie G M G J Mulders, Melissa van der Windt, Eric A P Steegers, Régine P M Steegers-Theunissen
BACKGROUND: Worldwide, placenta-related complications contribute to adverse pregnancy outcomes, such as pre-eclampsia, fetal growth restriction and preterm birth, with implications for the future health of mothers and offspring. The placenta develops in the periconception period and forms the interface between mother and embryo/fetus. An unhealthy periconceptional maternal lifestyle, such as smoking, alcohol and under- and over-nutrition, can detrimentally influence placental development and function...
November 8, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/30406389/a-proteomics-metabolomics-approach-indicates-changes-in-hypothalamic-glutamate-gaba-metabolism-of-adult-female-rats-submitted-to-intrauterine-growth-restriction
#8
Amanda P Pedroso, Ana P S Dornellas, Adriana P de Souza, Josias F Pagotto, Lila M Oyama, Cláudia M O Nascimento, Jelena Klawitter, Uwe Christians, Alexandre K Tashima, Eliane Beraldi Ribeiro
PURPOSE: Intrauterine growth restriction (IUGR) has been shown to induce the programming of metabolic disturbances and obesity, associated with hypothalamic derangements. The present study aimed at investigating the effects of IUGR on the protein and metabolite profiles of the hypothalamus of adult female rats. METHODS: Wistar rats were mated and either had ad libitum access to food (control group) or received only 50% of the control intake (restricted group) during the whole pregnancy...
November 7, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/30400594/pregnancy-in-chronic-kidney-disease-need-for-higher-awareness-a-pragmatic-review-focused-on-what-could-be-improved-in-the-different-ckd-stages-and-phases
#9
REVIEW
Giorgina B Piccoli, Elena Zakharova, Rossella Attini, Margarita Ibarra Hernandez, Alejandra Orozco Guillien, Mona Alrukhaimi, Zhi-Hong Liu, Gloria Ashuntantang, Bianca Covella, Gianfranca Cabiddu, Philip Kam Tao Li, Guillermo Garcia-Garcia, Adeera Levin
Pregnancy is possible in all phases of chronic kidney disease (CKD), but its management may be difficult and the outcomes are not the same as in the overall population. The prevalence of CKD in pregnancy is estimated at about 3%, as high as that of pre-eclampsia (PE), a better-acknowledged risk for adverse pregnancy outcomes. When CKD is known, pregnancy should be considered as high risk and followed accordingly; furthermore, since CKD is often asymptomatic, pregnant women should be screened for the presence of CKD, allowing better management of pregnancy, and timely treatment after pregnancy...
November 5, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/30400067/a-new-p-ile66serfs-93-igf2-variant-is-associated-with-pre-and-postnatal-growth-retardations
#10
Denise Rockstroh, Heike Pfäffle, Diana Le Duc, Franziska Rößler, Franziska Schlensog-Schuster, John T Heiker, Juergen Kratzsch, Wieland Kiess, Johannes Lemke, Rami Abou Jamra, Roland Pfäffle
OBJECTIVE: The IGF/IGF1R axis is involved in the regulation of human growth. Both IGF1 and IGF2 can bind to the IGF1R in order to promote growth via the downstream PI3K/AKT pathway. Pathogenic mutations in IGF1 and IGF1R determine intrauterine growth restriction and affect postnatal body growth. However, to date there are only few reports of pathogenic IGF2 mutations causing severe prenatal, as well as postnatal growth retardations. RESULTS: Here we describe a de novo c...
October 1, 2018: European Journal of Endocrinology
https://www.readbyqxmd.com/read/30400060/nutrient-sensor-signaling-pathways-and-cellular-stress-in-fetal-growth-restriction
#11
REVIEW
Bethany Hart, Elizabeth Morgan, Emilyn Alejandro
Fetal growth restriction is one of the most common obstetrical complications resulting in significant perinatal morbidity and mortality. The most frequent etiology of human singleton fetal growth restriction is placental insufficiency, which occurs secondary to reduced utero-placental perfusion, abnormal placentation, impaired trophoblast invasion and spiral artery remodeling, resulting in altered nutrient and oxygen transport. Two nutrient-sensing proteins involved in placental development and glucose and amino acid transport are mechanistic target of rapamycin (mTOR) and O-linked N-acetylglucosamine transferase (OGT), which are both regulated by availability of oxygen...
October 1, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/30399107/chromosomal-microarray-analysis-results-from-pregnancies-with-various-ultrasonographic-anomalies
#12
Lena Sagi-Dain, Idit Maya, Adi Reches, Ayala Frumkin, Julia Grinshpun-Cohen, Reeval Segel, Esther Manor, Morad Khayat, Tamar Tenne, Ehud Banne, Adel Shalata, Hagith Yonath, Racheli Berger, Amihood Singer, Shay Ben-Shachar
OBJECTIVE: To examine chromosomal microarray analysis results in pregnancies with various ultrasonographic anomalies and to characterize the copy number variants in diverse fetal phenotypes. METHODS: We retrospectively examined chromosomal microarray analyses of amniocenteses performed nationwide as a result of fetal ultrasonographic anomalies (structural defects, fetal growth restriction, and polyhydramnios) between January 2013 and September 2017. The rate of abnormal chromosomal microarray findings was compared between the different phenotypes and with a previously described control population of 15,225 pregnancies with normal ultrasonographic findings...
November 5, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30399092/serial-third-trimester-ultrasonography-compared-with-routine-care-in-uncomplicated-pregnancies-a-randomized-controlled-trial
#13
Olaide Ashimi Balogun, Baha M Sibai, Claudia Pedroza, Sean C Blackwell, Tyisha L Barrett, Suneet P Chauhan
OBJECTIVE: To evaluate whether serial ultrasound examinations in the third trimester increase identification of a composite of growth or amniotic fluid abnormalities when compared with routine care among pregnancies that are uncomplicated between 24 0/7 and 30 6/7 weeks of gestation. METHODS: Women without complications between 24 0/7 and 30 6/7 weeks of gestation were randomized (NCT0270299) to either routine care (control arm) or ultrasound examination every 4 weeks (intervention arm)...
November 5, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/30396654/placental-mri-shows-preservation-of-brain-volume-in-growth-restricted-fetuses-who-suffer-substantial-reduction-of-putative-functional-placenta-tissue-pfpt
#14
D Javor, C Nasel, S Dekan, G M Gruber, K Chalubinski, D Prayer
OBJECTIVE: Recently, a potentially useful diagnostic approach based on MR diffusion-tensor-imaging (DTI) was reported for the estimation of putative functional placenta tissue (PFPT), thus providing direct information about placental function. Yet, the relation between reduced PFPT and the phenomenon of brain-sparing remains unclear. This study aimed to investigate the relation between brain-sparing and reduced PFPT volume, as found in fetuses with intrauterine growth restriction (IUGR)...
November 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/30396465/a-prophylactic-low-dose-aspirin-earlier-than-12-weeks-until-delivery-should-be-considered-to-prevent-preeclampsia
#15
Jing Zhu, Rong Huang, Jinwen Zhang, Weiping Ye, Jun Zhang
Clinical trials and meta-analyses have demonstrated that low-dose aspirin can reduce the risk of preeclampsia and fetal growth restriction in high-risk pregnant women. Current obstetric guidelines recommend that the administration of low-dose aspirin to prevent preeclampsia be initiated after 12 weeks' gestation. This starting time was chosen to minimize possible risks of maternal bleeding and fetal anomalies. However, evidence from reproductive medicine, where low-dose aspirin is commonly recommended to use before and in early pregnancy, as well as existing literature, does not support these concerns...
December 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/30392118/infant-regulatory-behavior-problems-during-first-month-of-life-and-neurobehavioral-outcomes-in-early-childhood
#16
Elena Toffol, Ville Rantalainen, Marius Lahti-Pulkkinen, Polina Girchenko, Jari Lahti, Soile Tuovinen, Jari Lipsanen, Pia M Villa, Hannele Laivuori, Esa Hämäläinen, Eero Kajantie, Anu-Katriina Pesonen, Katri Räikkönen
Whether infant regulatory behavior problems already in the first month of life indicate an increased risk of childhood neurobehavioral problems, and whether maternal depression in the postpartum and early childhood underpins these associations remain unclear. Altogether, 2049-2364 mothers from the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Neonatal Perception Inventory on regulatory behavior problems at the infant's age of 15.6 days (SD 3.2, range 1-30), the Infant Behavior Questionnaire-Revised on temperament at 6...
November 3, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/30390347/assessment-of-uterine-artery-geometry-and-hemodynamics-in-human-pregnancy-with-4d-flow-mri-and-its-correlation-with-doppler-ultrasound
#17
Eileen Hwuang, Marta Vidorreta, Nadav Schwartz, Brianna F Moon, Kirpal Kochar, Matthew Dylan Tisdall, John A Detre, Walter R T Witschey
BACKGROUND: Uterine artery (UtA) hemodynamics might be used to predict risk of hypertensive pregnancy disorders, including preeclampsia and intrauterine growth restriction. PURPOSE OR HYPOTHESIS: To determine the feasibility of 4D flow MRI in pregnant subjects by characterizing UtA anatomy, computing UtA flow, and comparing UtA velocity, and pulsatility and resistivity indices (PI, RI) with transabdominal Doppler ultrasound (US). STUDY TYPE: Prospective cross-sectional study from June 6, 2016, to May 2, 2018...
November 3, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/30390249/skeletal-muscle-damage-in-intrauterine-growth-restriction
#18
Leonard Năstase, Dragos Cretoiu, Silvia Maria Stoicescu
Intrauterine growth restriction (IUGR) represents a rate of fetal growth that is less than average for the population and the growth potential of a specific infant. IUGR produces infants who are small for gestational age (SGA) but also appropriate for gestational age (AGA). It refers to growth less than expected for gestational age and is most often under 10th percentiles for age. It develops during the late second and third trimesters of gestation. The etiology of IUGR is multifactorial. One of the most important factors which leads to IUGR is a decrease of nutrients and oxygen delivered to the fetus by the placenta...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30384377/the-landscape-of-non-coding-rna-in-an-adult-pig-model-of-intrauterine-growth-restriction
#19
Linyuan Shen, Shunhua Zhang, Qiang Li, Yuhua Fu, Guoqing Tang, Yanzhi Jiang, Mingzhou Li, Jinyong Wang, Xuewei Li, Lianqiang Che, Li Zhu
BACKGROUND/AIMS: Intrauterine growth restriction (IUGR) is a risk factor for adult metabolic syndrome, but how this disease is regulated by lncRNAs and circRNAs remains elusive. METHODS: Here, we employed adult IUGR and normal pigs as models to evaluate the expression of various global lncRNAs and circRNAs in pig livers using RNA-seq. RESULTS: In total, we obtained 1,162 million raw reads of approximately 104.54 Gb high quality data. After a strict five-step filtering process, 3,368 lncRNAs were identified, including 300 differentially expressed lncRNAs (p < 0...
November 1, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30382946/sialic-acid-is-a-critical-fetal-defense-against-maternal-complement-attack
#20
Markus Abeln, Iris Albers, Ulrike Peters-Bernard, Kerstin Flächsig-Schulz, Elina Kats, Andreas Kispert, Stephen Tomlinson, Rita Gerardy-Schahn, Anja Münster-Kühnel, Birgit Weinhold
The negatively charged sugar sialic acid (Sia) occupies the outermost position in the bulk of cell surface glycans. Lack of sialylated glycans due to genetic ablation of the Sia activating enzyme CMP-sialic acid synthase (CMAS) resulted in embryonic lethality around day 9.5 post coitum (E9.5) in mice. Developmental failure was caused by complement activation on trophoblasts in Cmas-/- implants accompanied by infiltration of maternal neutrophils at the fetal-maternal interface, intrauterine growth restriction, impaired placental development and a thickened Reichert's membrane...
November 1, 2018: Journal of Clinical Investigation
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