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"Growth restriction"

Damian Warzecha, Eliza Kobryń, Marta Bagińska, Dorota Bomba-Opoń
BACKGROUND: Fetal growth restriction (FGR) is an unclearly defined condition described as a fetal weight which is too low in relation to gestational age. It is recognized in 10-15% of singleton pregnancies and can lead to severe complications, including stillbirth. To reduce the adverse fetal and neonatal outcomes, many medical interventions are being introduced by obstetricians. These, like all medical procedures, may induce further complications, such as preterm labor and its consequences...
July 19, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Abhishek Chopra, Anup Thakur, Pankaj Garg, Neelam Kler, Kanwal Gujral
BACKGROUND: Delayed cord clamping is the standard of care in infants not requiring resuscitation; however effects of cord clamping strategies have not been evaluated systematically in small for gestational age (SGA) infants. The primary objective was to compare effects of delayed cord clamping (DCC) and early cord clamping (ECC) on serum ferritin at 3 months in SGA infants born at ≥35 weeks. The secondary objectives were to compare hematological parameters, clinical outcomes in neonatal period and growth at 3 months of age...
July 18, 2018: BMC Pediatrics
Katia Motta, Patricia R L Gomes, Paola M Sulis, Silvana Bordin, Alex Rafacho
A rise in plasma triacylglycerol levels is a common physiological occurrence during late gestation and excess of glucocorticoids (GCs) has been shown to impair lipid metabolism. Based on those observations, we investigated whether the administration of dexamethasone during the late gestational period could exacerbate this pregnancy associated hypertriacylglycerolemia in rats. For this, female Wistar rats were treated with dexamethasone (0.2 mg/kg of body mass in the drinking water on days 14-19 of pregnancy; DP group) or equivalent days in the virgin rats (DV group)...
2018: Frontiers in Physiology
Kelly K Ferguson, Youfei Yu, David E Cantonwine, Thomas F McElrath, John D Meeker, Bhramar Mukherjee
BACKGROUND: Ultrasound measures are valuable for epidemiologic studies of risk factors for growth restriction. Longitudinal measurements enable investigation of rates of change and identification of windows where growth is impacted more acutely. However, missing data can be problematic in these studies, limiting sample size, ability to characterise windows of vulnerability, and in some instances creating bias. We sought to compare a parametric linear mixed model (LMM) approach to multiple imputation in this setting with multiple imputation by chained equation (MICE) methodology...
July 17, 2018: Paediatric and Perinatal Epidemiology
Enoch Odame Anto, William K B A Owiredu, Samuel Asamoah Sakyi, Cornelius Archer Turpin, Richard K D Ephraim, Linda Ahenkorah Fondjo, Christian Obirikorang, Eric Adua, Emmanuel Acheampong
BACKGROUND: Advanced maternal age (AMA) has been associated with negative pregnancy outcomes. Oxidative stress (OS) and defective placental dysfunction are contributing factors. This study determined the association between AMA and adverse pregnancy outcomes, OS biomarkers and angiogenic growth mediators (AGMs) in normal pregnancies. METHODS: This prospective cohort study conducted at the Obstetrics and Gynaecology (O&G) Department of the Komfo Anokye Teaching Hospital (KATH) finally included 175 normal pregnant women comprising, 58 AMA (35-45 years), 55 (30-34 years) and 62 optimal childbearing age (20-29 years)...
2018: PloS One
Mary Frances Lopez, Lingyun Zheng, Ji Miao, Reddy Gali, Grzegorz Gorski, Joel N Hirschhorn
Newborns with intrauterine growth-restriction are at increased risk of mortality and life-long co-morbidities. Insulin-like growth factor-II (IGF2) deficiency in humans as well as in mice leads to intrauterine growth restriction and decreased neonatal glycogen stores. The present study aims to further characterize the metabolic and transcriptional consequences of Igf2 deficiency in the newborn. We found that, despite being born significantly smaller than their wild-type (Igf2+/+ ) littermates, brain size was preserved in Igf2 knockout (Igf2-/- ), consistent with nutritional deficiency...
July 17, 2018: American Journal of Physiology. Endocrinology and Metabolism
Ke-Jun Ye, Jie Dai, Ling-Yun Liu, Meng-Jia Peng
The guilt by association (GBA) principle has been widely used to predict gene functions, and a network‑based approach may enhance the confidence and stability of the analysis compared with focusing on individual genes. Fetal growth restriction (FGR), is the second primary cause of perinatal mortality. Therefore, the present study aimed to predict the optimal gene functions for FGR using a network‑based GBA method. The method was comprised of four parts: Identification of differentially‑expressed genes (DEGs) between patients with FGR and normal controls based on gene expression data; construction of a co‑expression network (CEN) dependent on DEGs, using the Spearman correlation coefficient algorithm; collection of gene ontology (GO) data on the basis of a known confirmed database and DEGs; and prediction of optimal gene functions using the GBA algorithm, for which the area under the receiver operating characteristic curve (AUC) was obtained for each GO term...
June 29, 2018: Molecular Medicine Reports
Ricardo D Bennun, Julia H Harfin
Bilateral complete clefts represent the result of an incomplete fusion with all the morphologic components present. It is well known that patients with bilateral cleft lip and palate have typical characteristics such as insufficient medial face development with an orthodontic class III tendency, flat nose and short columella with abnormal nasolabial angle, bilateral oronasal fistulas, alterations in the number and position of the lateral incisors, and agenesis or supernumerary teeth. Successfully solving these cases, results in a difficult challenge and studies showing extended follow-up are not frequent...
July 13, 2018: Journal of Craniofacial Surgery
Petra Klepac, Igor Locatelli, Sara Korošec, Nino Künzli, Andreja Kukec
There is a growing number of studies on the association between ambient air pollution and adverse pregnancy outcomes, but their results have been inconsistent. Consequently, a comprehensive review of this research area is needed. There was a wide variability in studied pregnancy outcomes, observed gestational windows of exposure, observed ambient air pollutants, applied exposure assessment methods and statistical analysis methods Gestational duration, preterm birth, (low) birth weight, and small for gestational age/intrauterine growth restriction were most commonly investigated pregnancy outcomes...
July 5, 2018: Environmental Research
Fahad Zadjali, Aida Al-Yahyaee, Maryam Al-Nabhani, Saif Al-Mubahesi, Arunodaya Gujjar, Sameer Raniga, Almundher Al-Maawali
Aminoacyl-tRNA synthetases (ARSs) canonical function is to conjugate specific amino acids to cognate tRNA that are required for the first step of protein synthesis. Genetic mutations that cause dysfunction or absence of ARSs result in various neurodevelopmental disorders. The human phenylalanine-tRNA synthetase (PheRS) is a tetrameric protein made of two a subunits coded by FARSA gene and two b subunits coded by FARSB gene. We describe eight affected individuals from an extended family with a multisystemic recessive disease manifest as a significant growth restriction, brain calcifications, and interstitial lung disease...
July 16, 2018: Human Mutation
Mandy Williams, Sue Turner, Emily Butler, Jason Gardosi
Antenatal surveillance of fetal growth is an essential part of good maternity care, as lack of detection of fetal growth restriction is directly associated with stillbirth and perinatal morbidity. New algorithms and guidelines provide care pathways which rely on regular third trimester ultrasound biometry and plotting of estimated fetal weight in pregnancies considered to be at increased risk, and their implementation has increased pressures on ultrasound resources. Customised growth charts have improved the distinction between constitutional and pathological smallness and reduced unnecessary referrals...
May 2018: Ultrasound: Journal of the British Medical Ultrasound Society
Isabel Ochando, Melanie Cristine Alonzo Martínez, Ana María Serrano, Antonio Urbano, Eduardo Cazorla, Dolores Calvo, Joaquín Rueda
Reported cases of distal 15q interstitial duplications are uncommon and do not result in a recognizable pattern of abnormalities. Some studies report prenatal overgrowth, while others describe growth retardation. We present molecular cytogenetic characterization of a 14 Mb interstitial duplication, encompassing 81 Online Mendelian Inheritance in Man (OMIM) genes, in a fetus with single umbilical artery and short limbs. We propose that growth restriction, previously described and present in our patient, may be due to duplication of a gene or genes contained in the 15q24 region...
2018: Application of Clinical Genetics
Xiulian Wang, Jianzhen Zhu, Chong Guo, Huiqing Shi, Dan Wu, Fanfan Sun, Li Shen, Pin Ge, Jian Wang, Xiangying Hu, Jinjin Chen, Guangjun Yu
Objectives To compare growth profiles of children born small for gestational age (SGA) with those born the appropriate size for gestational age (AGA), and examine expected growth patterns for SGA in early childhood. Methods A survey on 23,871 SGA children was conducted in Shanghai. Data were collected at 1, 2, 4, 6, 8, 10, 12, 18, 24, 36, 48, and 60 months of age (+30 days). A check-up included assessments of weight, height, and head circumference. Results At 5 years old, weight, height, and head circumference were lower in SGA children compared with AGA children...
January 1, 2018: Journal of International Medical Research
Mu-Yi Yang, Zhen-Yu Diao, Zhi-Yin Wang, Gui-Jun Yan, Guang-Feng Zhao, Ming-Ming Zheng, Anyi Dai, Yi-Min Dai, Yali Hu
Preeclampsia is associated with over-activation of the innate immune system in the placenta, in which toll-like receptor 4 (TLR4) plays an essential part. With their potent anti-inflammatory effects, statins have been suggested as potential prevention or treatment of preeclampsia, although evidence remains inadequate. Herewith, we investigated whether pravastatin could ameliorate preeclampsia-like phenotypes in a previously established lipopolysaccharide (LPS)-induced rat preeclampsia model, through targeting the TLR4/NF-κB pathway...
July 12, 2018: Journal of Biomedical Research
Valentina Canti, Stefania Del Rosso, Marta Tonello, Roberta Lucianò, Ariela Hoxha, Lavinia A Coletto, Isadora Vaglio Tessitore, Susanna Rosa, Angelo A Manfredi, Maria Teresa Castiglioni, Amelia Ruffatti, Patrizia Rovere-Querini
OBJECTIVE: Antibodies that recognize the phosphatidylserine/prothrombin complex (antiphosphatidylserine/ prothrombin antibodies; aPS/PT) might reveal enhanced thrombotic risk in patients with systemic lupus erythematosus. Little is known about their association with pregnancy complications in the antiphospholipid syndrome (APS). METHODS: We enrolled 55 patients with APS who were seeking pregnancy in 2 Italian hospitals. Antiphospholipid antibodies (aPL), including anticardiolipin antibodies, anti-β2 -glycoprotein I antibodies, lupus-like anticoagulant, and aPS/PT antibodies were assessed, and the patients were prospectively followed for 24 months...
July 15, 2018: Journal of Rheumatology
Marion Imbert-Bouteille, Frédéric Tran Mau Them, Julien Thevenon, Thomas Guignard, Vincent Gatinois, Jean-Baptiste Riviere, Anne Boland, Vincent Meyer, Jean-François Deleuze, Elodie Sanchez, Florence Apparailly, David Geneviève, Marjolaine Willems
Alazami syndrome (AS) (MIM# 615071) is an autosomal recessive microcephalic primordial dwarfism (PD) with recognizable facial features and severe intellectual disability due to depletion or loss of function variants in LARP7. To date, 15 patients with AS have been reported. Here we describe two consanguineous Algerian sisters with Alazami PD due to LARP7 homozygous pathogenic variants detected by whole exome sequencing. By comparing these two additional cases with those previously reported, we strengthen the key features of AS: severe growth restriction, severe intellectual disability and some distinguishing facial features such as broad nose, malar hypoplasia, wide mouth, full lips and abnormally set teeth...
July 10, 2018: European Journal of Medical Genetics
Eimer G O'Malley, Shona Cawley, Ciara M E Reynolds, Rachel A K Kennedy, Anne Molloy, Michael J Turner
OBJECTIVES: Using detailed dietary and supplement questionnaires in early pregnancy, we compared the dietary intakes of micronutrients and macronutrients at the first prenatal visit of women who reported continuing to smoke during pregnancy with the intakes of women who were non-smokers. DESIGN: Cross-sectional study conducted between June 2014 and March 2016. SETTING: Stand-alone tertiary maternity hospital in an urban setting with approximately 8000 deliveries per year...
July 12, 2018: BMJ Open
Peter Kozlowski, Tilo Burkhardt, Ulrich Gembruch, Markus Gonser, Christiane Kähler, Karl-Oliver Kagan, Constantin von Kaisenberg, Philipp Klaritsch, Eberhard Merz, Horst Steiner, Sevgi Tercanli, Klaus Vetter, Thomas Schramm
First-trimester screening between 11 + 0 and 13 + 6 weeks with qualified prenatal counseling, detailed ultrasound, biochemical markers and maternal factors has become the basis for decisions about further examinations. It detects numerous structural and genetic anomalies. The inclusion of uterine artery Doppler and PlGF screens for preeclampsia and fetal growth restriction. Low-dose aspirin significantly reduces the prevalence of severe preterm eclampsia. Cut-off values define groups of high, intermediate and low probability...
July 12, 2018: Ultraschall in der Medizin
Tal Rafaeli-Yehudai, Majdi Imterat, Amos Douvdevani, Dan Tirosh, Neta Benshalom-Tirosh, Salvatore Andrea Mastrolia, Ruthy Beer-Weisel, Vered Klaitman, Reut Riff, Shirley Greenbaum, Alex Alioshin, Gal Rodavsky Hanegbi, Giuseppe Loverro, Mariana Rita Catalano, Offer Erez
OBJECTIVES: Preeclampsia and fetal growth restriction are obstetrical syndromes associated with abnormal placental implantation and changes in the activation status of maternal leukocytes. This study is aimed to determine by a simple, rapid fluorescent assay the changes in maternal serum total cell-free DNA (t-cfDNA) concentrations in women with preeclampsia and those with fetal growth restriction (FGR). STUDY DESIGN: A cross-sectional study was conducted measuring maternal serum t-cfDNA concentrations...
2018: PloS One
Marina Colella, Alice Frerot, Aline Rideau Batista Novais, Olivier Baud
Fetal Growth Restriction (FGR) is one of the most common noxious antenatal conditions in humans, affecting 10% of all pregnancies, inducing a substantial proportion of preterm delivery and leading to a significant increase in perinatal mortality, neurological handicaps and chronic diseases in adulthood. This review summarizes the current knowledge about the postnatal consequences of FGR, with a particular emphasis on the long-term consequences on respiratory, cardiovascular and neurological structures and functions...
July 11, 2018: Current Pediatric Reviews
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