Xiyan Liao, Qin Zeng, Limin Xie, Haowei Zhang, Wanyu Hu, Liuling Xiao, Hui Zhou, Fanqi Wang, Wanqin Xie, Jianfeng Song, Xiaoxiao Sun, Dandan Wang, Yujin Ding, Yayi Jiao, Wuqian Mai, Wufuer Aini, Xiaoyan Hui, Wei Liu, Willa A Hsueh, Tuo Deng
T cell infiltration into white adipose tissue (WAT) drives obesity-induced adipose inflammation, but the mechanisms of obesity-induced T cell infiltration into WAT remain unclear. Our single-cell RNA sequencing reveals a significant impact of adipose stem cells (ASCs) on T cells. Transplanting ASCs from obese mice into WAT enhances T cell accumulation. C-C motif chemokine ligand 5 (CCL5) is upregulated in ASCs as early as 4 weeks of high-fat diet feeding, coinciding with the onset of T cell infiltration into WAT during obesity...
March 15, 2024: Cell Reports