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https://www.readbyqxmd.com/read/30427544/poor-vitamin-k-status-is-associated-with-low-bone-mineral-density-and-increased-fracture-risk-in-end-stage-renal-disease
#1
Pieter Evenepoel, Kathleen Claes, Bjorn Meijers, Michaël Laurent, Bert Bammens, Maarten Naesens, Ben Sprangers, Hans Pottel, Etienne Cavalier, Dirk Kuypers
Chronic kidney disease and osteoporosis are major public health problems associated with an aging population. Vitamin K insufficiency is prevalent among patients with end-stage renal disease (ESRD). Preliminary data indicate that poor vitamin K status may compromise bone health and that increased inflammation may be in the causal pathway. We performed an ancillary analysis of data collected in the frame of prospective observational cohort studies exploring various aspects of bone health in de novo renal transplant recipients to investigate the association between vitamin K status, inflammation, bone mineral density, and incident clinical fractures...
November 14, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/30425709/gdf15-regulates-malat-1-circular-rna-and-inactivates-nf%C3%AE%C2%BAb-signaling-leading-to-immune-tolerogenic-dcs-for-preventing-alloimmune-rejection-in-heart-transplantation
#2
Yixin Zhang, Guangfeng Zhang, Yanling Liu, Renqi Chen, Duo Zhao, Vivian McAlister, Tina Mele, Kexiang Liu, Xiufen Zheng
Recombinant human growth differentiation factor 15 (rhGDF15) affects dendritic cell (DC) maturation. However, whether GDF15 is expressed in DCs and its roles and signaling in DCs remain largely unknown. It is unclear whether GDF15-DCs can induce immune tolerance in heart transplantation (HT). This study aims to understand the impact of endogenous GDF15 on DC's development, function, underlying molecular mechanism including circular RNA (circRNA). This study will also explore GDF15-DC-mediated immune modulation in HT...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30425065/silencing-of-hdac6-as-a-therapeutic-target-in-chronic-lymphocytic-leukemia
#3
Kamira Maharaj, John J Powers, Alex Achille, Susan Deng, Renee Fonseca, Mibel Pabon-Saldana, Steven N Quayle, Simon S Jones, Alejandro Villagra, Eduardo M Sotomayor, Eva Sahakian, Javier Pinilla-Ibarz
Although the treatment paradigm for chronic lymphocytic leukemia (CLL) is rapidly changing, the disease remains incurable, except with allogeneic bone marrow transplantation, and resistance, relapsed disease, and partial responses persist as significant challenges. Recent studies have uncovered roles for epigenetic modification in the regulation of mechanisms contributing to malignant progression of CLL B cells. However, the extent to which epigenetic modifiers can be targeted for therapeutic benefit in CLL patients remains poorly explored...
November 13, 2018: Blood Advances
https://www.readbyqxmd.com/read/30424945/concentrated-bone-marrow-aspirate-may-decrease-postoperative-cyst-occurrence-rate-in-autologous-osteochondral-transplantation-for-osteochondral-lesions-of-the-talus
#4
Yoshiharu Shimozono, Youichi Yasui, Eoghan T Hurley, Rebecca A Paugh, Timothy W Deyer, John G Kennedy
PURPOSE: To clarify if the use of concentrated bone marrow aspirate (CBMA) would affect both postoperative functional outcomes and magnetic resonance imaging (MRI) outcomes compared with those of autologous osteochondral transplantation (AOT) alone; in addition, to assess the efficacy of CBMA reducing the presence of postoperative cyst formation following AOT in the treatment of osteochondral lesions of the talus. METHODS: Fifty-four (92%) of 59 eligible patients who underwent AOT between 2004 and 2008 were retrospectively assessed at a minimum of 5-year follow-up...
November 10, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/30423551/constitutively-photomorphogenic-1-reduces-the-sensitivity-of-chronic-lymphocytic-leukemia-cells-to-fludarabine-through-promotion-of-ubiquitin-mediated-p53-degradation
#5
Chunling Fu, Xuanxuan Shi, Yanqing Gong, Yan Wan, Zengtian Sun, Hengliang Shi, Zhenzhen Wang, Christian Marinaccio, John D Crispino, Kailin Xu
BACKGROUND/AIMS: Chronic Lymphocytic leukemia (CLL) is characterized by accumulation of cells in the G0/G1 phase of the cell cycle and resistance to apoptosis due to gene mutation or abnormal gene expression. In our previous study, constitutively photomorphogenic 1 (COP1) was shown to be upregulated in Binet C-phase CLL patients. Based on the negative regulation of COP1 in the repair of DNA damage, we further studied the function of COP1 in CLL cell apoptosis induced by fludarabine in vitro and in vivo...
November 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30418563/renal-tubular-dysfunction-fully-accounts-for-plasma-biochemical-abnormalities-in-type-1a-pseudohypoparathyroidism
#6
Raffaella Labbadia, Carla Bizzarri, Mafalda Mucciolo, Giacomo Di Zazzo, Isabella Guzzo, Marco Cappa, Francesco Emma, Luca Dello Strologo
Context: Type 1A Pseudohypoparathyroidism (PHP-1A) is characterized by target organ resistance to parathyroid hormone (PTH). Patients can show various dysmorphic features, but renal failure is not classically described. Case Description: A female patient came to our attention at the age of seven years with characteristic signs of PTH resistance, namely hypocalcemia, hyperphosphatemia and high serum PTH levels. She also presented hypothyroidism, early-onset obesity, short metacarpal bones and multiple subcutaneous ossifications leading to a clinical diagnosis of pseudohypoparathyroidism In addition to her genetic condition, she had bilateral renal hypodysplasia slowly progressing to end-stage kidney disease...
November 9, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/30418423/an-easy-and-sensitive-method-to-profile-the-antibody-specificities-of-hla-specific-memory-b-cells
#7
Gonca E Karahan, Juliette Krop, Caroline Wehmeier, Yvonne de Vaal, Janneke Langerak-Langerak, Dave L Roelen, Neubury M Lardy, Frederike J Bemelman, Ineke Ten Berge, Marlies E J Reinders, Cees van Kooten, Frans H J Claas, Sebastiaan Heidt
BACKGROUND: Pre-transplant immunological risk assessment is currently based on donor-specific HLA antibodies in serum. Despite being an excellent source for antibodies produced by bone marrow-residing plasma cells, serum analysis does not provide information on the memory B cell compartment. While B cell culture supernatants can be used to detect memory B cell derived HLA antibodies, low IgG concentrations can preclude detectability of HLA antibodies in luminex single antigen bead (SAB) assays...
November 9, 2018: Transplantation
https://www.readbyqxmd.com/read/30417559/brdu-incorporation-in-multiparameter-flow-cytometry-a-new-cell-cycle-assessment-approach-in-multiple-myeloma
#8
Guilhem Requirand, Nicolas Robert, Stéphanie Boireau, Laure Vincent, Anja Seckinger, Salaheddine Bouhya, Patrice Ceballos, Guillaume Cartron, Dirk Hose, Bernard Klein, Jérôme Moreaux
BACKGROUND: Mutiple myeloma (MM) is a neoplasia characterized by the accumulation of malignant plasma cells (PC) in the bone marrow. Although proliferation markers have been studied in MM, none of the current staging systems include them. Moreover, approaches used to analyze proliferation do not separate MM cells (MMCs) from normal PC. METHODS: In this study, we combined multiparameter flow cytometry and BrdU incorporation or Ki67 staining to analyze MM cell proliferation in 44 monoclonal gammopathy of undetermined significance (MGUS), 153 newly diagnosed MM patients and 69 MM patients at relapse...
November 12, 2018: Cytometry. Part B, Clinical Cytometry
https://www.readbyqxmd.com/read/30416833/a-rare-case-of-pembrolizumab-induced-reactivation-of-hepatitis-b
#9
Anita Pandey, Susan Ezemenari, Maksim Liaukovich, Ivan Richard, Avezbakiyev Boris
Hepatitis B virus (HBV) infection is common across the world, especially in Asia, Africa, Southern Europe, and Latin America. The association of HBV infection in patients suffering from different oncological conditions is well established. Many cases of HBV reactivation have been reported in patients on immunosuppressive chemotherapy and in patients undergoing hematopoietic bone marrow transplantations. Only one case has been reported so far of HBV reactivation in a patient treated with programmed cell death receptor 1 (PD-1) checkpoint inhibitors in the setting of HIV status...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/30416646/scaffold-free-cartilage-cell-sheet-combined-with-bone-phase-bmscs-scaffold-regenerate-osteochondral-construct-in-mini-pig-model
#10
Feiyu Wang, Yihui Hu, Dongmei He, Guangdong Zhou, Edward Ellis
Tissue-engineered condyles provide a promising approach for end-stage osteoarthritis to reconstruct normal physiological structure and function of the temporomandibular joint (TMJ). However, lack of successful biological condyles in large animals restricts clinical translation. Scaffold-free cartilage cell sheets do not contain any polymeric material which potentially risks local nonspecific inflammatory reactions. In this study, we used cartilage cell sheets covering bone marrow mesenchymal stem cells-Polycaprolactone/Hydroxyapatite (BMSCs-PCL/HA) scaffolds (cell sheet group) transplanted subcutaneously and intramuscularly in mini-pigs...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/30416172/hypercalcemia-and-osteolytic-bone-lesions-as-the-major-symptoms-in-a-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma-patient-a-rare-case
#11
Jian Hua, Shiro Ide, Shin Ohara, Tomoyuki Uchida, Morihiro Inoue, Kazuteru Ohashi, Masao Hagihara
We report a 40-year-old woman who presented with multiple osteolytic bone lesions and hypercalcemia, which are rarely caused by chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). Although receiving intensive chemotherapy and allogeneic transplantation, the patient had a poor outcome with an overall survival of 2 years. To our knowledge, this presentation is extremely rare for B-chronic lymphocytic leukemia, and new treatment strategies may be needed for long-term control of the disease.
November 9, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
https://www.readbyqxmd.com/read/30411265/minimal-residual-disease-in-multiple-myeloma-impact-on-response-assessment-prognosis-and-tumor-heterogeneity
#12
Natalie Berger, Seunghee Kim-Schulze, Samir Parekh
Multiple Myeloma (MM) therapy has evolved rapidly over the past decade. With current multidrug combinations and autologous transplant, rates of overall response exceed 90% and complete response (CR) more than 50% in some studies. Unfortunately, despite higher rates of CR, relapse rates remain high suggesting that persistent disease may not be measured by current techniques. Traditionally, response rates were defined by urine and serum protein electrophoresis, immunofixation and histopathological absence of clonal plasma cells in the bone marrow...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30410198/born-to-donate-proposals-for-savior-sibling-regulation-in-latin-america
#13
Alejandra Zúñiga-Fajuri
A Savior Sibling is a child who is born to provide an organ, bone marrow or cell transplant, to a sibling that is affected with a fatal disease. There are created with the in vitro fertilization and pre-implantation genetic diagnosis and, in the process, the ethical standards for organ donation of children become less demanding. Therefore, we propose that the authorization of the technique considers, unavoidably, the opinion of an impartial third party that can guarantee the welfare of the child. We develop a critical analysis of the laws that regulate the creation of babies to serve as organ donors...
September 30, 2018: Colombia Médica: CM
https://www.readbyqxmd.com/read/30409466/-second-allogeneic-hematopoietic-stem-cell-transplant-guidelines-from-the-francophone-society-of-bone-marrow-transplantation-and-cellular-therapy-sfgm-tc
#14
Nabil Yafour, Marie Anne Couturier, Saba Azarnoush, Stéphane Girault, Eric Hermet, Stavroula Masouridi Levrat, Aline Schmidt, Mauricette Michallet, Pascaline Etancelin, Thierry Guillaume, Florent Malard, Anne Sirvent, Ibrahim Yakoub-Agha, Xavier Poiré
Disease recurrence and graft dysfunction after allogeneic hematopoietic stem cell transplantation (allo-HSCT) currently remain among the major causes of treatment failure in malignant and non-malignant hematological diseases. A second allo-HSCT is a valuable therapeutic option to salvage those situations. During the 8th annual harmonization workshops of the french Society of bone marrow transplantation and cellular therapy (SFGM-TC), a designated working group reviewed the literature in order to elaborate unified guidelines on feasibility, indications, donor choice and conditioning in the case of a second allo-HSCT...
November 5, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/30409193/metformin-induces-apoptosis-in-mesenchymal-stromal-cells-and-dampens-their-therapeutic-efficacy-in-infarcted-myocardium
#15
Xiao He, Meng-Wei Yao, Ming Zhu, Dong-Lan Liang, Wei Guo, Yi Yang, Rong-Seng Zhao, Ting-Ting Ren, Xiang Ao, Wei Wang, Chun-Yu Zeng, Hua-Ping Liang, Dong-Po Jiang, Jian Yu, Xiang Xu
BACKGROUND: Cardiovascular complications, especially myocardial infarctions (MIs), are the leading mortality cause in diabetic patients. The transplantation of stem cells into damaged hearts has had considerable success as a treatment for MI, although whether antidiabetic drugs affect the therapeutic efficacy of stem cell transplantation is still unknown. This study aims to understand whether and how metformin, one of the first-line drugs used to treat type 2 diabetes mellitus (T2 DM), induces mesenchymal stromal cell (MSC) apoptosis and dampens their cardioprotective effect after transplantation into infarcted hearts...
November 8, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30409036/early-and-late-protective-effect-of-bone-marrow-mononuclear-cell-transplantation-on-radiation-induced-vascular-dysfunction-and-skin-lesions
#16
Valérie Holler, Valerie Buard, Telma Roque, Claire Squiban, Marc Benderitter, Stephane Flamant, Radia Tamarat
Skin lesions caused by accidental exposure to radiation or by radiotherapy are a major clinical challenge. We evaluated the effect of bone marrow mononuclear cells (BMMNC) on collagen remodeling and vascular function in radiation-induced skin lesions in the acute and late phases in mice. We studied the effect of BMMNC transplantation in a mouse model of cutaneous radiation injury combining local skin gamma-irradiation and biopsy punch wound. Mice were first irradiated, punched and then BMMNC were intramuscularly administered...
November 9, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/30408564/family-mismatched-allogeneic-stem-cell-transplantation-for-myelofibrosis-report-from-the-chronic-malignancies-working-party-of-ebmt
#17
Kavita Raj, Diderik-Jan Eikema, Donal P McLornan, Eduardo Olavarria, Henric-Jan Blok, Stefania Bregante, Fabio Ciceri, Jakob Passweg, Per Ljungman, Nicolaas Schaap, Kristina Carlson, Tsila Zuckerman, Liesbeth C de Wreede, Liisa Volin, Yener Koc, J Diez-Martin, Peter Brossart, Dominik Wolf, Didier Blaise, Paolo Di Bartolomeo, Antonin Vitek, Marie Robin, Yakoub-Agha I, Yves Chalandon, Nicolaus Kroger
This analysis includes 56 Myelofibrosis (MF) patients transplanted from family mismatched donor between 2009-2015 enrolled in the European Society for Blood and Marrow Transplantation (EBMT) database. The median age was 57 years (range, 38-72); 75% had primary MF and 25% had secondary MF. JAK2 V617F was mutated in 61%. Donors were HLA mismatched at 2 or more loci. Stem cells were sourced from bone marrow in 66% and peripheral blood in 34%. The median CD34+ cell dose was 4.8 × 106 /kg (1.7-22.9 × 106 /kg) (n=43)...
November 5, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/30408408/olig2-expressing-mesenchymal-stem-cells-enhance-functional-recovery-after-contusive-spinal-cord-injury
#18
Hwan-Woo Park, Soonyi Oh, Kyung Hee Lee, Bae Hwan Lee, Mi-Sook Chang
Background and Objectives: Glial scarring and inflammation after spinal cord injury (SCI) interfere with neural regeneration and functional recovery due to the inhibitory microenvironment of the injured spinal cord. Stem cell transplantation can improve functional recovery in experimental models of SCI, but many obstacles to clinical application remain due to concerns regarding the effectiveness and safety of stem cell transplantation for SCI patients. In this study, we investigated the effects of transplantation of human mesenchymal stem cells (hMSCs) that were genetically modified to express Olig2 in a rat model of SCI...
October 31, 2018: International Journal of Stem Cells
https://www.readbyqxmd.com/read/30408118/risk-factors-associated-with-prolonged-hospital-length-of-stay-18-year-retrospective-study-of-hospitalizations-in-a-tertiary-healthcare-center-in-mexico
#19
Braulio A Marfil-Garza, Pablo F Belaunzarán-Zamudio, Alfonso Gulias-Herrero, Antonio Camiro Zuñiga, Yanink Caro-Vega, David Kershenobich-Stalnikowitz, José Sifuentes-Osornio
BACKGROUND: Hospital length-of-Stay has been traditionally used as a surrogate to evaluate healthcare efficiency, as well as hospital resource utilization. Prolonged Length-of-stay (PLOS) is associated with increased mortality and other poor outcomes. Additionally, these patients represent a significant economic problem on public health systems and their families. We sought to describe and compare characteristics of patients with Normal hospital Length-of-Stay (NLOS) and PLOS to identify sociodemographic and disease-specific factors associated with PLOS in a tertiary care institution that attends adults with complicated diseases from all over Mexico...
2018: PloS One
https://www.readbyqxmd.com/read/30406279/association-of-serum-sclerostin-with-bone-sclerostin-in-chronic-kidney-disease-is-lost-in-glucocorticoid-treated-patients
#20
Henrik Boltenstål, Abdul Rashid Qureshi, Geert J Behets, Bengt Lindholm, Peter Stenvinkel, Patrick C D'Haese, Mathias Haarhaus
The osteocytic protein sclerostin inhibits bone turnover. Serum sclerostin rises early in chronic kidney disease (CKD), but if this reflects osteocyte sclerostin production is unclear, since sclerostin is also expressed in extra-skeletal tissue. Glucocorticoid treatment impacts on serum sclerostin, but the effect on the association between serum and bone sclerostin is unknown. We sought to determine whether serum sclerostin reflects bone sclerostin in different CKD stages and how this association is influenced by glucocorticoid treatment...
November 7, 2018: Calcified Tissue International
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