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https://www.readbyqxmd.com/read/30222250/bone-marrow-chimeras-to-study-neuroinflammation
#1
Nathalie Laflamme, Paul Préfontaine, Antoine Lampron, Serge Rivest
Bone marrow transplantation is the standard of care for a host of diseases such as leukemia and multiple myeloma, as well as genetically inherited metabolic diseases affecting the central nervous system. In mouse models, bone marrow transplantation has proven a valuable tool for understanding the hematopoietic system and the homing of hematopoietic cells to their target organs. Many techniques have been developed to create chimeric mice, animals with a hematopoietic system derived from a genetic background that differs from the rest of the body...
September 17, 2018: Current Protocols in Immunology
https://www.readbyqxmd.com/read/30222084/building-specialized-nursing-practice-capacity-in-bangladesh-an-educational-program-to-prepare-nurses-to-care-for-oncology-and-bone-marrow-transplant-patients-in-dhaka-bangladesh
#2
Anne-Marie Barron, Jenna Moran, Shabnam Sultana Nina, Jason Harlow, Meena Gyawali, Farhad Hossain, Mark Brezina, Caroline Callahan, Judy Curran, Colleen Danielson, Ellen Fitzgerald, Judy Foster, Emily Erhardt, Christine Shaughnessy, Albert C Yeh, Bimalangshu R Dey
In 2012, the Minister of Health and other leaders in the Bangladesh government approached Massachusetts General Hospital to establish the country's first bone marrow transplant program at Dhaka Medical College Hospital to serve the needs of the people of Bangladesh. Stated goals of this collaboration included a broad focus on the care of oncology patients with a specific emphasis on care of patients with hematologic malignancies and of women with gynecologic cancers. The purpose of this article is to describe the international nursing collaboration between Massachusetts General Hospital, Simmons College, the AK Khan Healthcare Trust in Dhaka, and Dhaka Medical College Hospital that was established to share nursing knowledge and to build specialized professional nursing capacities to deliver high-quality cancer care in the public sector...
September 2018: Journal of Global Oncology
https://www.readbyqxmd.com/read/30221616/coronary-artery-occlusion-secondary-to-graft-versus-host-disease-after-bone-marrow-transplant-in-a-21-year-old
#3
Sihong Huang, Paul Martin, M Jay Campbell
Coronary artery disease after bone marrow transplantation is rare in children and young adults. We report the case of a 21-year-old who developed coronary artery disease and acute myocardial infarction secondary to graft versus host disease following bone marrow transplantation. Physicians caring for young patients after bone marrow transplantation should be aware of the potential for coronary artery disease and evaluate appropriately.
September 17, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/30220110/monozygotic-twins-diagnosed-simultaneously-with-ram-immunophenotype-acute-myeloid-leukemia
#4
Rolla F Abu-Arja, Jamie L Dargart, Rajinder P S Bajwa, Samir B Kahwash, Jeffery J Auletta, Hemalatha G Rangarajan
AML with the RAM immunophenotype is associated with extremely poor prognosis. We report a rare case of monozygotic twins presenting simultaneously at the age of 2 years with RAM AML. Each twin underwent a myeloablative 7/10 unrelated umbilical cord blood transplant. Pretransplant Twin A's bone marrow was negative for MRD by flow cytometry (<0.01%) unlike Twin B's bone marrow (0.07%). Twin A is alive in remission 3 years from transplant. Twin B developed primary graft failure, but subsequently rescued with a haploidentical stem cell transplant...
September 15, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/30219279/therapeutic-inhibition-of-spleen-tyrosine-kinase-in-inflammatory-macrophages-using-plga-nanoparticles-for-the-treatment-of-non-alcoholic-steatohepatitis
#5
Dhadhang Wahyu Kurniawan, Arun Kumar Jajoriya, Garima Dhawan, Divya Mishra, Josepmaria Argemi, Ramon Bataller, Gert Storm, Durga Prasad Mishra, Jai Prakash, Ruchi Bansal
Non-alcoholic steatohepatitis (NASH) is the leading cause of cirrhosis worldwide and the most rapidly growing indication for liver transplantation. Macrophages are the important cellular component in the inflammatory milieu in NASH. Inflammatory and pro-fibrotic mediators produced by macrophages causes significant tissue injury in many inflammatory diseases. Therefore, inhibition of the inflammatory macrophages would be a promising approach to attenuate NASH. In this study, we studied the implication of SYK pathway in NASH, and investigated PLGA nanoparticles-based delivery of SYK pathway inhibitor as an effective and promising therapeutic approach for the treatment of NASH...
September 13, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30218653/functional-mandibular-reconstruction-with-double-barrel-fibular-flap-and-primary-osseointegrated-dental-implants-improve-facial-esthetic-outcome
#6
Jie Chen, Ping Yin, Ning Li, Limeng Wu, Xinchun Jian, Canhua Jiang
PURPOSE: Osseointegrated dental implants in fibula free flaps can be used to reconstruct segmental mandibular defects resulting from head and neck resections. The double-barrel fibula flap (DBFF) has been applied as a modified method to overcome insufficient fibular width. This article describes the use of the DBFF with simultaneous dental implant placement as a superior method for esthetic mandibular reconstruction. MATERIALS AND METHODS: From 2012 to 2015, 26 patients underwent mandibular reconstruction with a free fibula flap and immediate dental implant placement after segmental mandibulectomies...
August 22, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/30218509/bone-marrow-transplantation-for-primary-immune-deficiency-disorders-in-india-past-present-and-future
#7
Satya Prakash Yadav
No abstract text is available yet for this article.
August 15, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/30216807/preconditioning-of-bone-marrow-derived-mesenchymal-stem-cells-with-n-acetyl-l-cysteine-enhances-bone-regeneration-via-reinforced-resistance-to-oxidative-stress
#8
Jun Watanabe, Masahiro Yamada, Kunimichi Niibe, Maolin Zhang, Takeru Kondo, Minoru Ishibashi, Hiroshi Egusa
Oxidative stress on transplanted bone marrow-derived mesenchymal stem cells (BMSCs) during acute inflammation is a critical issue in cell therapies. N-acetyl-L cysteine (NAC) promotes the production of a cellular antioxidant molecule, glutathione (GSH). The aim of this study was to investigate the effects of pre-treatment with NAC on the apoptosis resistance and bone regeneration capability of BMSCs. Rat femur-derived BMSCs were treated in growth medium with or without 5 mM NAC for 6 h, followed by exposure to 100 μM H2 O2 for 24 h to induce oxidative stress...
September 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/30214646/dysfunction-and-therapeutic-potential-of-endothelial-progenitor-cells-in-diabetes-mellitus
#9
REVIEW
Lidong Hu, Si-Cheng Dai, Xiaojun Luan, Jingsong Chen, Anthony Cannavicci
Diabetes mellitus (DM) is a chronic, multifactorial metabolic disease whereby insulin deficiency or resistance results in hyperglycemia. Endothelial cells (ECs) form the innermost layer of the blood vessel and produce and release a variety of vasoactive substances and growth factors to regulate vascular homeostasis and angiogenesis. Hyperglycemia and insulin resistance can cause endothelial dysfunction, leading to vascular complications such as coronary artery disease, peripheral arterial disease, diabetic nephropathy, neuropathy and retinopathy...
October 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/30213875/bone-marrow-specific-loss-of-abi1-induces-myeloproliferative-neoplasm-with-features-resembling-human-myelofibrosis
#10
Anna Chorzalska, John Morgan, Nagib Ahsan, Diana O Treaba, Adam J Olszewski, Max Petersen, Nathan Kingston, Yan Cheng, Kara Lombardo, Christoph Schorl, Xiaoqing Yu, Roberta Zini, Annalisa Pacilli, Alexander Tepper, Jillian Coburn, Anita Hryniewicz-Jankowska, Ting C Zhao, Elena Oancea, John L Reagan, Olin Liang, Leszek Kotula, Peter J Quesenberry, Philip A Gruppuso, Rossella Manfredini, Alessandro Maria Vannucchi, Patrycja M Dubielecka
Although the pathogenesis of primary myelofibrosis (PMF) and other myeloproliferative neoplasms (MPNs) is linked to constitutive activation of the JAK-STAT pathway, JAK inhibitors neither have curative nor MPN-stem cell-eradicating potential, indicating that other targetable mechanisms are contributing to pathophysiology of MPNs. We previously demonstrated that Abelson interactor 1 (Abi-1), a negative regulator of Abelson kinase 1, functions as a tumor suppressor. Here we present data showing that bone marrow-specific deletion of Abi1 in a novel mouse model leads to development of an MPN-like phenotype resembling human PMF...
September 13, 2018: Blood
https://www.readbyqxmd.com/read/30213828/tlr7-ligand-r848-prevents-mouse-graft-versus-host-disease-and-cooperates-with-anti-il-27-antibody-for-maximal-protection-and-treg-upregulation
#11
Mélanie Gaignage, Reece G Marillier, Perrine M Cochez, Laure Dumoutier, Catherine Uyttenhove, Jean-Paul Coutelier, Jacques Van Snick
In spite of considerable therapeutic progress, acute graft-versus-host disease still limits allogeneic hematopoietic cell transplantation. We recently reported that mouse infection with nidovirus lactate dehydrogenase elevating virus impairs disease in non-conditioned B6D2F1 recipients of parental B6 spleen cells. As this virus activates TLR7, we tested pharmacologic TLR7 ligand R848 in this model and observed complete survival if donor and recipients were treated before transplantation. Mixed lymphocyte culture performed 48 h after R848-treatment of normal mice demonstrated that both T cell allo-responsiveness and antigen presentation by CD11b+ and CD8α+ dendritic cells were inhibited...
September 13, 2018: Haematologica
https://www.readbyqxmd.com/read/30213555/expression-of-sting-is-increased-in-liver-tissues-from-patients-with-nafld-and-promotes-macrophage-mediated-hepatic-inflammation-and-fibrosis-in-mice
#12
Xianjun Luo, Honggui Li, Linqiang Ma, Jing Zhou, Xin Guo, Shih-Lung Woo, Ya Pei, Linda R Knight, Michael Deveau, Yanming Chen, Xiaoxian Qian, Xiaoqiu Xiao, Qifu Li, Xiangbai Chen, Yuqing Huo, Kelly McDaniel, Heather Francis, Shannon Glaser, Fanyin Meng, Gianfranco Alpini, Chaodong Wu
BACKGROUND & AIMS: Transmembrane protein 173 (TMEM173 or STING) signaling by macrophage activates the type I interferon-mediated innate immune response. The innate immune response contributes to hepatic steatosis and non-alcoholic fatty liver disease (NAFLD). We investigated wither STING regulates diet-induced in hepatic steatosis, inflammation, and liver fibrosis in mice. METHODS: Mice with disruption of Tmem173 (STINGgt ) on a C57BL/6J background, mice without disruption of this gene (controls), and mice with disruption of Tmem173 only in myeloid cells were fed a standard chow diet, a high-fat diet (HFD, 60% fat calories), or a methionine- and choline-deficient diet (MCD)...
September 10, 2018: Gastroenterology
https://www.readbyqxmd.com/read/30212683/progranulin-in-the-hematopoietic-compartment-protects-mice-from-atherosclerosis
#13
Andrew D Nguyen, Thi A Nguyen, Rajesh K Singh, Delphine Eberlé, Jiasheng Zhang, Jess Porter Abate, Anatalia Robles, Suneil Koliwad, Eric J Huang, Frederick R Maxfield, Tobias C Walther, Robert V Farese
BACKGROUND AND AIMS: Progranulin is a circulating protein that modulates inflammation and is found in atherosclerotic lesions. Here we determined whether inflammatory cell-derived progranulin impacts atherosclerosis development. METHODS: Ldlr-/- mice were transplanted with bone marrow from wild-type (WT) or Grn-/- (progranulin KO) mice (referred to as Tx-WT and Tx-KO, respectively). RESULTS: After 10 weeks of high-fat diet feeding, both groups displayed similarly elevated plasma levels of cholesterol and triglycerides...
August 30, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/30211195/autologous-platelet-rich-gel-combined-with-in-vitro-amplification-of-bone-marrow-mesenchymal-stem-cell-transplantation-to-treat-the-diabetic-foot-ulcer-a-case-report
#14
Qinan Wu, Xiaotian Lei, Liu Chen, Yanling Zheng, Hongmei Huang, Cheng Qian, Ziwen Liang
The diabetic foot ulcer (DFU) is the leading cause of the high mortality and morbidity rates of diabetes patients, and the DFU accounts for approximately 15% of all diagnosed diabetes cases in China. Traditional treatment is typically ineffective for DFUs. Here, we present a case of DFU that was successfully treated with an autologous platelet-rich gel (APG) and in vitro amplification of bone marrow mesenchymal stem cell (BMMSC) transplantation. A 54-year-old woman initially presented with a right foot diabetic ulcer at the hospital...
August 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/30210754/leveraging-jak-stat-regulation-in-myelofibrosis-to-improve-outcomes-with-allogeneic-hematopoietic-stem-cell-transplant
#15
REVIEW
Michael Byrne, Bipin Savani, Michael R Savona
Primary myelofibrosis (PMF) is a disease characterized by bone marrow fibrosis, extramedullary hematopoiesis, risk of transformation to acute myeloid leukemia, and a substantial symptom burden with diminished quality of life. Allogeneic hematopoietic cell transplantation (HCT) is the only curative option; however, disease relapse and graft versus host disease (GVHD) are significant barriers to long-term survival. The discovery of the JAK2 V617F mutation, and subsequent development of JAK inhibitors, resulted in improved survival and significant improvements in spleen volumes and symptom scores...
September 2018: Therapeutic Advances in Hematology
https://www.readbyqxmd.com/read/30210495/bltr1-in-monocytes-emerges-as-a-therapeutic-target-for-vascular-inflammation-with-a-subsequent-intimal-hyperplasia-in-a-murine-wire-injured-femoral-artery
#16
Seung E Baek, So Y Park, Sun S Bae, Koanhoi Kim, Won S Lee, Chi D Kim
Given the importance of high-mobility group box 1 (HMGB1) and 5-lipoxygenase (5-LO) signaling in vascular inflammation, we investigated the role of leukotriene signaling in monocytes on monocyte-to-macrophage differentiation (MMD) induced by HMGB1, and on vascular inflammation and subsequent intimal hyperplasia in a mouse model of wire-injured femoral artery. In cultured primary bone marrow-derived cells (BMDCs) stimulated with HMGB1, the number of cells with macrophage-like morphology was markedly increased in association with an increased expression of CD11b/Mac-1, which were attenuated in cells pre-treated with Zileuton, a 5-LO inhibitor as well as in 5-LO-deficient BMDCs...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30209999/neuroprotection-by-human-dental-pulp-mesenchymal-stem-cells-from-billions-to-nano
#17
Chaitra Venugopal, K Shobha, Kiranmai S Rai, Venkata Bharatkumar Pinnelli, Bindu M Kutty, Anandh Dhanushkodi
Mesenchymal stem cell (MSC) therapy in recent years have gained significant attention. Though the functional outcomes following MSC therapy for neurodegenerative diseases are convincing, various mechanisms for the functional recovery are being debated. Nevertheless, recent studies convincingly demonstrated that recovery following MSC therapy could be reiterated with MSC secretome per se thereby shifting the dogma from cell therapy to cell "based" therapy. In addition to various functional proteins, stem cell secretome also includes extracellular membrane vesicles like exosomes...
September 13, 2018: Current Gene Therapy
https://www.readbyqxmd.com/read/30209118/transferrin-receptor-2-is-a-potential-novel-therapeutic-target-for-beta-thalassemia-evidence-from-a-murine-model
#18
Irene Artuso, Maria Rosa Lidonnici, Sandro Altamura, Giacomo Mandelli, Mariateresa Pettinato, Martina U Muckenthaler, Laura Silvestri, Giuliana Ferrari, Clara Camaschella, Antonella Nai
β-thalassemias are genetic disorders characterized by anemia, ineffective erythropoiesis and iron overload. Current treatment of severe cases is based on blood transfusion and iron chelation or allogeneic bone marrow transplantation. Novel approaches are explored for non-transfusion-dependent patients (thalassemia intermedia) who develop anemia and iron overload. Here we investigated the erythropoietin receptor partner, Transferrin Receptor 2 (TFR2), as a novel potential therapeutic target. We generated a murine model of thalassemia intermedia specifically lacking bone marrow Tfr2: being their erythroid cells more susceptible to erythropoietin stimulation, mice show improved erythropoiesis and red blood cells morphology and partial correction of anemia and iron-overload...
September 12, 2018: Blood
https://www.readbyqxmd.com/read/30208992/supernumerary-incisors-in-cb6f1-mice-conditioned-with-chemotherapy-and-total-body-irradiation-before-bone-marrow-transplantation
#19
Cynthia J Doane, Karuna Patil, Emely A Hoffman, Jessica Stokes, Emmanuel Katsanis, David G Besselsen
Multiple adult female CB6F1 mice presented with supernumerary incisors after preconditioning with chemotherapy and totalbody irradiation for bone marrow transplantation (BMT). Mice received nonmyeloablative total body irradiation (3 Gy) andeither cyclophosphamide or bendamustine, followed by BMT and posttransplantation cyclophosphamide or bendamustine.Here we describe the clinical presentation, μCT findings, and histopathologic evaluation of the affected mice. These analysesconfirmed the gross diagnosis and revealed details of the abnormal tooth morphology...
September 12, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/30198369/a-practical-self-made-device-in-parathyroid-autotransplantation-for-patients-with-secondary-hyperparathyroidism
#20
Lei Du, Xiwei Zhang, Liang Yan, Hao Zhang, Xuefeng Tang, Xiancheng Kong, Gang Liu, Jianping Huang
Objective Secondary hyperparathyroidism (sHPT) is one of the most serious complications in patients on long-term hemodialysis. These patients may suffer from metabolic bone diseases, severe atherosclerosis, and undesirable cardiovascular events. Endoscopic parathyroidectomy with autotransplantation is a treatment option for those who do not respond to clinical management. This study aimed to investigate practical use of a self-made device in parathyroid autotransplantation for patients with sHPT, and to compare this device with ordinary surgical scissors...
September 9, 2018: Journal of International Medical Research
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