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https://www.readbyqxmd.com/read/28615375/inclusion-of-almonds-in-a-cholesterol-lowering-diet-improves-plasma-hdl-subspecies-and-cholesterol-efflux-to-serum-in-normal-weight-individuals-with-elevated-ldl-cholesterol
#1
Claire E Berryman, Jennifer A Fleming, Penny M Kris-Etherton
Background: Almonds may increase circulating HDL cholesterol when substituted for a high-carbohydrate snack in an isocaloric diet, yet little is known about the effects on HDL biology and function.Objective: The objective was to determine whether incorporating 43 g almonds/d in a cholesterol-lowering diet would improve HDL subspecies and function, which were secondary study outcomes.Methods: In a randomized, 2-period, crossover, controlled-feeding study, a diet with 43 g almonds/d (percentage of total energy: 51% carbohydrate, 16% protein, and 32% total and 8% saturated fat) was compared with a similar diet with an isocaloric muffin substitution (58% carbohydrate, 15% protein, and 26% total and 8% saturated fat) in men and women with elevated LDL cholesterol...
June 14, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28558755/evaluation-of-a-species-specific-c-reactive-protein-assay-for-the-dog-on-the-abx-pentra-400-clinical-chemistry-analyzer
#2
Sarah Hindenberg, Stefanie Klenner-Gastreich, Nicole Kneier, Sabine Zielinsky, Kris Gommeren, Natali Bauer, Andreas Moritz
BACKGROUND: A canine-specific immunoturbidimetric CRP assay, Gentian Canine CRP Immunoassay) with species-specific controls and calibrators was introduced and recently evaluated on the clinical chemistry analyzer Abbott Architect c4000 as well as on the Olympus AU600. Aims of our study were 1) to independently evaluate the canine-specific CRP assay on the ABX Pentra 400 clinical chemistry analyzer in comparison to the previously validated human-based immunoturbidimetric assay (Randox Canine CRP assay) and 2) to assess the impact of different sample types (serum versus heparinized plasma) on the results...
May 30, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28458593/intravenous-lidocaine-old-school-drug-new-purpose-reduction-of-intractable-pain-in-patients-with-chemotherapy-induced-peripheral-neuropathy
#3
Sandra A S van den Heuvel, Selina E I van der Wal, Lotte A Smedes, Sandra A Radema, Nens van Alfen, Kris C P Vissers, Monique A H Steegers
Background. Treatment of intractable pain due to chemotherapy induced peripheral neuropathy (CIPN) is a challenge. Intravenous (iv) lidocaine has shown to be a treatment option for neuropathic pain of different etiologies. Methods. Lidocaine (1.5 mg/kg in 10 minutes followed by 1.5 mg/kg/h over 5 hours) was administered in nine patients with CIPN, and analgesic effect was evaluated during infusion and after discharge. The immediate effect of lidocaine on pressure pain thresholds (PPT) and the extent of the stocking and glove distribution of sensory abnormalities (cold and pinprick) were assessed...
2017: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/28402694/serum-phosphate-and-retinal-microvascular-changes-the-multi-ethnic-study-of-atherosclerosis-and-the-beaver-dam-eye-study
#4
Rupal Mehta, Alexander Hodakowski, Xuan Cai, Kris E Lee, Bryan R Kestenbaum, Ian H de Boer, Amani Fawzi, Tien Yin Wong, Joachim Ix, Barbara Klein, Ronald Klein, Tamara Isakova
PURPOSE: Higher levels of serum phosphate are strongly linked to increased risk of cardiovascular disease and therapies aimed to lower serum phosphate are employed in the management of patients with chronic kidney disease (CKD). Data are limited, however, on serum phosphate as a risk factor for microvascular disease in community-based populations. It is important to determine the impact of novel risk factors, such as phosphate, on the microvasculature. METHODS: We conducted a prospective study of 3919 individuals in the Multi-Ethnic Study of Atherosclerosis (MESA) and 3544 individuals in the Beaver Dam Eye Study (BDES) to test the associations of serum phosphate with retinopathy and retinal vessel caliber, and change in retinopathy severity and change in retinal vessel caliber...
April 12, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28356431/acute-peanut-consumption-alters-postprandial-lipids-and-vascular-responses-in-healthy-overweight-or-obese-men
#5
Xiaoran Liu, Alison M Hill, Sheila G West, Rachel M Gabauer, Cindy E McCrea, Jennifer A Fleming, Penny M Kris-Etherton
Background: Postprandial hyperlipidemia is associated with impaired endothelial function. Peanut consumption favorably affects the lipid and lipoprotein profile; however, the effects on endothelial function remain unclear.Objective: The purpose of the study was to evaluate the effects of acute peanut consumption as part of a high-fat meal on postprandial endothelial function.Methods: We conducted a randomized, controlled, crossover postprandial study to evaluate the effect of acute peanut consumption on postprandial lipids and endothelial function as assessed by flow-mediated dilatation (FMD) of the brachial artery in 15 healthy overweight or obese men [mean age: 26...
May 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28337079/comparison-of-amikacin-pharmacokinetics-in-neonates-following-implementation-of-a-new-dosage-protocol
#6
Kaitlin M Hughes, Peter N Johnson, Michael P Anderson, Kris C Sekar, Robert C Welliver, Jamie L Miller
OBJECTIVES: The primary aim was to compare attainment of goal serum amikacin concentrations using two dosage regimens in patients admitted to a neonatal intensive care unit. Secondary objectives included comparison of percentages of supratherapeutic trough concentrations, and subtherapeutic and supratherapeutic peak concentrations. METHODS: This was an Institutional Review Board-approved, retrospective study of neonates receiving amikacin during January-December 2013 (group 1) and January-December 2014 (group 2)...
January 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28208799/microbial-detoxification-of-deoxynivalenol-don-assessed-via-a-lemna-minor-l-bioassay-through-biotransformation-to-3-epi-don-and-3-epi-dom-1
#7
Ilse Vanhoutte, Laura De Mets, Marthe De Boevre, Valdet Uka, José Diana Di Mavungu, Sarah De Saeger, Leen De Gelder, Kris Audenaert
Mycotoxins are toxic metabolites produced by fungi. To mitigate mycotoxins in food or feed, biotransformation is an emerging technology in which microorganisms degrade toxins into non-toxic metabolites. To monitor deoxynivalenol (DON) biotransformation, analytical tools such as ELISA and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) are typically used. However, these techniques do not give a decisive answer about the remaining toxicity of possible biotransformation products. Hence, a bioassay using Lemna minor L...
February 13, 2017: Toxins
https://www.readbyqxmd.com/read/28190578/quarter-dose-quadruple-combination-therapy-for-initial-treatment-of-hypertension-placebo-controlled-crossover-randomised-trial-and-systematic-review
#8
Clara K Chow, Jay Thakkar, Alex Bennett, Graham Hillis, Michael Burke, Tim Usherwood, Kha Vo, Kris Rogers, Emily Atkins, Ruth Webster, Michael Chou, Hakim-Moulay Dehbi, Abdul Salam, Anushka Patel, Bruce Neal, David Peiris, Henry Krum, John Chalmers, Mark Nelson, Christopher M Reid, Mark Woodward, Sarah Hilmer, Simon Thom, Anthony Rodgers
BACKGROUND: Globally, most patients with hypertension are treated with monotherapy, and control rates are poor because monotherapy only reduces blood pressure by around 9/5 mm Hg on average. There is a pressing need for blood pressure-control strategies with improved efficacy and tolerability. We aimed to assess whether ultra-low-dose combination therapy could meet these needs. METHODS: We did a randomised, placebo-controlled, double-blind, crossover trial of a quadpill-a single capsule containing four blood pressure-lowering drugs each at quarter-dose (irbesartan 37·5 mg, amlodipine 1·25 mg, hydrochlorothiazide 6·25 mg, and atenolol 12·5 mg)...
March 11, 2017: Lancet
https://www.readbyqxmd.com/read/28149782/six-year-outcomes-in-neovascular-age-related-macular-degeneration-with-ranibizumab
#9
Julie Jacob, Heidi Brié, Anita Leys, Laurent Levecq, Filip Mergaerts, Kris Denhaerynck, Stefaan Vancayzeele, Eline Van Craeyveld, Ivo Abraham, Karen MacDonald
AIM: To evaluate the outcomes of ≥6y ranibizumab therapy in neovascular age-related macular degeneration (AMD). METHODS: HELIX was a retrospective, observational effectiveness study using medical records of patients treated in three clinics in Belgium. Patients had neovascular AMD and were initially treated with intravitreal ranibizumab (0.5 mg) between November 1, 2007 and October 31, 2008, had ≥6y of data available, and were treated on an ongoing, as-needed basis...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28147693/inverse-collimated-proton-radiography-for-imaging-thin-materials
#10
Matthew S Freeman, Jason Allison, Malcolm Andrews, Eric Ferm, John J Goett, Kris Kwiatkowski, Julian Lopez, Fesseha Mariam, Mark Marr-Lyon, Michael Martinez, Jason Medina, Patrick Medina, Frank E Merrill, Chris L Morris, Matthew M Murray, Paul Nedrow, Levi P Neukirch, Katherine Prestridge, Paolo Rigg, Alexander Saunders, Tamsen Schurman, Amy Tainter, Frans Trouw, Dale Tupa, Josh Tybo, Wendy Vogan-McNeil, Carl Wilde
Relativistic, magnetically focused proton radiography was invented at Los Alamos National Laboratory using the 800 MeV LANSCE beam and is inherently well-suited to imaging dense objects, at areal densities >20 g cm(-2). However, if the unscattered portion of the transmitted beam is removed at the Fourier plane through inverse-collimation, this system becomes highly sensitive to very thin media, of areal densities <100 mg cm(-2). Here, this inverse-collimation scheme is described in detail and demonstrated by imaging Xe gas with a shockwave generated by an aluminum plate compressing the gas at Mach 8...
January 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28073786/phase-1-study-of-twice-weekly-pulse-dose-and-daily-low-dose-erlotinib-as-initial-treatment-for-patients-with-egfr-mutant-lung-cancers%C3%A2
#11
H A Yu, C Sima, D Feldman, L L Liu, B Vaitheesvaran, J Cross, C M Rudin, M G Kris, W Pao, F Michor, G J Riely
Background: Patients with EGFR-mutant lung cancers treated with EGFR tyrosine kinase inhibitors (TKIs) develop clinical resistance, most commonly with acquisition of EGFR T790M. Evolutionary modeling suggests that a schedule of twice weekly pulse and daily low-dose erlotinib may delay emergence of EGFR T790M. Pulse dose erlotinib has superior central nervous system (CNS) penetration and may result in superior CNS disease control. Methods: We evaluated toxicity, pharmacokinetics, and efficacy of twice weekly pulse and daily low-dose erlotinib...
February 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28059869/a-longitudinal-supra-inguinal-fascia-iliaca-compartment-block-reduces-morphine-consumption-after-total-hip-arthroplasty
#12
Matthias Desmet, Kris Vermeylen, Imré Van Herreweghe, Laurence Carlier, Filiep Soetens, Stijn Lambrecht, Kathleen Croes, Hans Pottel, Marc Van de Velde
BACKGROUND AND OBJECTIVES: The role of a fascia iliaca compartment block (FICB) for postoperative analgesia after total hip arthroplasty (THA) remains questionable. High-dose local anesthetics and a proximal injection site may be essential for successful analgesia. High-dose local anesthetics may pose a risk for local anesthetic systemic toxicity. We hypothesized that a high-dose longitudinal supra-inguinal FICB is safe and decreases postoperative morphine consumption after anterior approach THA...
May 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28031418/peripheral-inflammatory-biomarkers-for-myocardial-infarction-risk-a-prospective-community-based-study
#13
Zhijun Wu, Zhe Huang, Wei Jin, Eric B Rimm, Alice H Lichtenstein, Penny M Kris-Etherton, Shouling Wu, Xiang Gao
BACKGROUND: Most previous studies regarding chronic inflammation and risk of myocardial infarction (MI) have lacked repeated measures of high-sensitivity C-reactive protein (hs-CRP) and/or white blood cell (WBC) count over time. We examined whether cumulative average and longitudinal changes in these biomarkers were associated with subsequent MI risk. METHODS: In this prospective, community-based study, we included 82544 Chinese participants [66796 men and 15748 women; mean (SD) age 55...
March 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/27825636/cabozantinib-in-patients-with-advanced-ret-rearranged-non-small-cell-lung-cancer-an-open-label-single-centre-phase-2-single-arm-trial
#14
Alexander Drilon, Natasha Rekhtman, Maria Arcila, Lu Wang, Andy Ni, Melanie Albano, Martine Van Voorthuysen, Romel Somwar, Roger S Smith, Joseph Montecalvo, Andrew Plodkowski, Michelle S Ginsberg, Gregory J Riely, Charles M Rudin, Marc Ladanyi, Mark G Kris
BACKGROUND: RET rearrangements are found in 1-2% of non-small-cell lung cancers. Cabozantinib is a multikinase inhibitor with activity against RET that produced a 10% overall response in unselected patients with lung cancers. To assess the activity of cabozantinib in patients with RET-rearranged lung cancers, we did a prospective phase 2 trial in this molecular subgroup. METHODS: We enrolled patients in this open-label, Simon two-stage, single-centre, phase 2, single-arm trial in the USA if they met the following criteria: metastatic or unresectable lung cancer harbouring a RET rearrangement, Karnofsky performance status higher than 70, and measurable disease...
December 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27820160/cross-centre-replication-of-suppressed-burrowing-behaviour-as-an-ethologically-relevant-pain-outcome-measure-in-the-rat-a-prospective-multicentre-study
#15
Rachel Wodarski, Ada Delaney, Camilla Ultenius, Rosie Morland, Nick Andrews, Catherine Baastrup, Luke A Bryden, Ombretta Caspani, Thomas Christoph, Natalie J Gardiner, Wenlong Huang, Jeffrey D Kennedy, Suguru Koyama, Dominic Li, Marcin Ligocki, Annika Lindsten, Ian Machin, Anton Pekcec, Angela Robens, Sanziana M Rotariu, Sabrina VoB, Marta Segerdahl, Carina Stenfors, Camilla I Svensson, Rolf-Detlef Treede, Katsuhiro Uto, Kazumi Yamamoto, Kris Rutten, Andrew S C Rice
Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication of suppressed burrowing behaviour in the complete Freund adjuvant (CFA)-induced model of inflammatory pain (unilateral, 1 mg/mL in 100 µL) was evaluated in 11 studies across 8 centres. Following a standard protocol, data from participating centres were collected centrally and analysed with a restricted maximum likelihood-based mixed model for repeated measures...
October 2016: Pain
https://www.readbyqxmd.com/read/27819799/dehydration-of-bacteriophages-in-electrospun-nanofibers-effect-of-excipients-in-polymeric-solutions
#16
Charmaine K W Koo, Kris Senecal, Andre Senecal, Sam R Nugen
Bacteriophages are viruses capable of infecting and lysing target bacterial cells; as such they have potential applications in agriculture for decontamination of foods, food contact surfaces and food rinse water. Although bacteriophages can retain infectivity long-term using lyophilized storage, the process of freeze-drying can be time consuming and expensive. In this study, electrospinning was used for dehydrating bacteriophages in polyvinylpyrrolidone polymer solutions with addition of excipients (sodium chloride, magnesium sulfate, Tris-HCl, sucrose) in deionized water...
December 2, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27720917/tetrahydrocannabinol-does-not-reduce-pain-in-patients-with-chronic-abdominal-pain-in-a-phase-2-placebo-controlled-study
#17
Marjan de Vries, Dagmar C M van Rijckevorsel, Kris C P Vissers, Oliver H G Wilder-Smith, Harry van Goor
BACKGROUND & AIMS: Delta-9-atetrahydrocannabinol (THC) is the most abundant cannabinoid from the plant Cannabis sativa. There is only equivocal evidence that THC has analgesic effects. We performed a phase 2 controlled trial to evaluate the analgesic efficacy, pharmacokinetics, safety, and tolerability of an oral tablet containing purified THC in patients with chronic abdominal pain. METHODS: Sixty-five patients with chronic abdominal pain for 3 months or more (numeric rating scale scores of 3 or more) after surgery or because of chronic pancreatitis were randomly assigned to groups given the THC tablet or identical matching placebos for 50-52 days...
October 5, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27643836/cross-centre-replication-of-suppressed-burrowing-behaviour-as-an-ethologically-relevant-pain-outcome-measure-in-the-rat-a-prospective-multicentre-study
#18
Rachel Wodarski, Ada Delaney, Camilla Ultenius, Rosie Morland, Nick Andrews, Catherine Baastrup, Luke A Bryden, Ombretta Caspani, Thomas Christoph, Natalie J Gardiner, Wenlong Huang, Jeffrey D Kennedy, Suguru Koyama, Dominic Li, Marcin Ligocki, Annika Lindsten, Ian Machin, Anton Pekcec, Angela Robens, Sanziana M Rotariu, Sabrina Vo, Marta Segerdahl, Carina Stenfors, Camilla I Svensson, Rolf-Detlef Treede, Katsuhiro Uto, Kazumi Yamamoto, Kris Rutten, Andrew S C Rice
Burrowing, an ethologically relevant rodent behaviour, has been proposed as a novel outcome measure to assess the global impact of pain in rats. In a prospective multicentre study using male rats (Wistar, Sprague-Dawley), replication of suppressed burrowing behaviour in the complete Freund adjuvant (CFA)-induced model of inflammatory pain (unilateral, 1 mg/mL in 100 µL) was evaluated in 11 studies across 8 centres. Following a standard protocol, data from participating centres were collected centrally and analysed with a restricted maximum likelihood-based mixed model for repeated measures...
October 2016: Pain
https://www.readbyqxmd.com/read/27635325/anxiolytic-effects-of-fluoxetine-and-nicotine-exposure-on-exploratory-behavior-in-zebrafish
#19
Matthew L Singer, Kris Oreschak, Zachariah Rhinehart, Barrie D Robison
Zebrafish (Danio rerio) have emerged as a popular model for studying the pharmacology and behavior of anxiety. While there have been numerous studies documenting the anxiolytic and anxiogenic effects of common drugs in zebrafish, many do not report or test for behavioral differences between the sexes. Previous studies have indicated that males and females differ in their baseline level of anxiety. In this study, we test for a sex interaction with fluoxetine and nicotine. We exposed fish to system water (control), 10 mg/L fluoxetine, or 1 mg/L nicotine for three minutes prior to being subjected to four minutes in an open-field drop test...
2016: PeerJ
https://www.readbyqxmd.com/read/27533287/evaluation-of-proton-pump-inhibitor-use-on-treatment-outcomes-with-ledipasvir-and-sofosbuvir-in-a-real-world-cohort-study
#20
Elliot B Tapper, Bruce R Bacon, Michael P Curry, Douglas T Dieterich, Steven L Flamm, Lauren E Guest, Kris V Kowdley, Yoori Lee, Naoky C Tsai, Zobair M Younossi, Nezam H Afdhal
Many patients with chronic hepatitis C virus (HCV) are on prolonged proton-pump inhibitor (PPI) therapy and wish to remain on PPI therapy once treatment for HCV starts. A preliminary report recently suggested decrease rates of sustained virological response (SVR) for patients taking concomitant PPI and ledipasvir/sofosbuvir (LDV/SOF). We sought to determine the effect of PPI use on the rate of SVR in a real-world cohort of 1,979 patients with chronic HCV treated with LDV/SOF. We collected clinical data and pharmacy dispensing records on patients taking 8, 12, or 24 weeks of LDV/SOF ± ribavirin (RBV)...
December 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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