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https://www.readbyqxmd.com/read/28346680/human-papillomavirus-in-cervical-cancer-and-oropharyngeal-cancer-one-cause-two-diseases
#1
REVIEW
Tara A Berman, John T Schiller
Human papillomavirus (HPV) causes greater than 5% of cancers worldwide, including all cervical cancers and an alarmingly increasing proportion of oropharyngeal cancers (OPCs). Despite markedly reduced cervical cancer incidence in industrialized nations with organized screening programs, cervical cancer remains the second most common cause of death from cancer in women worldwide, as developing countries lack resources for universal, high-quality screening. In the United States, HPV-related OPC is only 1 of 5 cancers with a rising incidence since 1975 and now has taken over the cervix as the most common site of HPV-related cancer...
March 27, 2017: Cancer
https://www.readbyqxmd.com/read/28346582/rates-and-characteristics-of-paid-malpractice-claims-among-us-physicians-by-specialty-1992-2014
#2
Adam C Schaffer, Anupam B Jena, Seth A Seabury, Harnam Singh, Venkat Chalasani, Allen Kachalia
Importance: Although physician concerns about medical malpractice are substantial, national data are lacking on the rate of claims paid on behalf of US physicians by specialty. Objective: To characterize paid malpractice claims by specialty. Design, Setting, and Participants: A comprehensive analysis was conducted of all paid malpractice claims, with linkage to physician specialty, from the National Practitioner Data Bank from January 1, 1992, to December 31, 2014, a period including an estimated 19...
March 27, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28346543/prevalence-of-non-alcoholic-fatty-liver-disease-and-risk-factors-for-advanced-fibrosis-and-mortality-in-the-united-states
#3
Michael H Le, Pardha Devaki, Nghiem B Ha, Dae Won Jun, Helen S Te, Ramsey C Cheung, Mindie H Nguyen
In the United States, non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and associated with higher mortality according to data from earlier National Health and Nutrition Examination Survey (NHANES) 1988-1994. Our goal was to determine the NAFLD prevalence in the recent 1999-2012 NHANES, risk factors for advanced fibrosis (stage 3-4) and mortality. NAFLD was defined as having a United States Fatty Liver Index (USFLI) > 30 in the absence of heavy alcohol use and other known liver diseases...
2017: PloS One
https://www.readbyqxmd.com/read/28346197/basics-of-compounding-with-dilutions-and-concentrates
#4
Loyd V Allen
Pharmacists use various sources for obtaining the active pharmaceutical ingredient for compounding medications. In many cases, it is the pure drug (United States Pharmacopeia, National Formulary, or similar grade); in some cases, it can be a commercial dosage form; and, in some cases, it may be a dilution or concentrate. If the drug is not present at full strength, then adjustments may be necessary to obtain the required quantity of drug. Also, in many cases, it is necessary to use a dilution or a concentrate of a drug due to safety and quality reasons...
January 2017: International Journal of Pharmaceutical Compounding
https://www.readbyqxmd.com/read/28346147/differences-in-short-and-long-sleep-durations-between-blacks-and-whites-attributed-to-emotional-distress-analysis-of-the-national-health-interview-survey-in-the-united-states
#5
Azizi A Seixas, Emmanuella Auguste, Mark Butler, Caryl James, Valerie Newsome, Evan Auguste, Vilma Aparecida da Silva Fonseca, Andres Schneeberger, Ferdinand Zizi, Girardin Jean-Louis
OBJECTIVES: The current study examined the role of emotional distress in explaining racial/ethnic differences in unhealthy sleep duration. DESIGN: Data from the 2004-2013 National Health Interview Survey were analyzed using SPSS 20. SETTING: Data were collected through personal household interviews in the United States. PARTICIPANTS: Of the total 261,686 participants (age≥18 years), 17.0% were black, 83.0% were white, and the mean age was 48 years (SE=0...
February 2017: Sleep Health
https://www.readbyqxmd.com/read/28346146/social-support-social-strain-sleep-quality-and-actigraphic-sleep-characteristics-evidence-from-a-national-survey-of-us-adults
#6
Joon Chung
OBJECTIVE: To determine the associations between average family and friend social support and strain over 10 years and sleep quality, sleep efficiency, total sleep time, and night-to-night total sleep time variability. PARTICIPANTS: Non-institutionalized English-speaking US adults aged 34-81 who participated in the MacArthur Study on Aging: Midlife in the United States. MEASUREMENTS: Sleep quality was assessed by the Pittsburgh Sleep Quality Index and by a 7-day daily diary...
February 2017: Sleep Health
https://www.readbyqxmd.com/read/28346133/creating-a-climate-that-catalyses-healthcare-innovation-in-the-united-kingdom-learning-lessons-from-international-innovators
#7
Kathrin Cresswell, Sarah Cunningham-Burley, Aziz Sheikh
BACKGROUND: The United Kingdom (UK) lags behind other high-income countries in relation to technological innovation in healthcare. In order to inform UK strategy on how to catalyse innovation, we sought to understand what national strategies can help to promote a climate for innovation in healthcare settings by extracting lessons for the UK from international innovators. METHODS: We undertook a series of qualitative semi-structured interviews with senior international innovators from a range of health related policy, care/service delivery, commercial and academic backgrounds...
January 25, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28346062/dietary-exposures-for-the-safety-assessment-of-seven-emulsifiers-commonly-added-to-foods-in-the-united-states-and-implications-for-safety
#8
Romina Shah, Renata Kolanos, Michael J DiNovi, Antonia Mattia, Kotaro J Kaneko
Dietary exposure assessment using food consumption data and ingredient use level is essential for assessing safety of food ingredients. Dietary exposure estimates are compared to safe intake levels, such as Acceptable Daily Intake (ADI). ADI is estimated by applying a safety factor to an experimentally determined no-observed-adverse-effect-level of a test substance. Two food ingredients classified as emulsifiers, sodium carboxymethylcellulose (CMC) and polysorbate 80 (P80), received attention recently due to their putative adverse effects on gut microbiota...
March 27, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28345681/-studies-on-lyme-disease-incidence-rates-in-selected-groups-of-forestry-workers-in-west-pomerania-2005-2014
#9
Tomasz Stawicki
BACKGROUND: The data collected by sanitary-epidemiological stations in 2005-2014 were analyzed to determine the incidence rates of borreliosis Lyme disease in the West Pomerania group of workers exposed to tick bites. MATERIAL AND METHODS: It was assumed that an adequate comparison of official epidemiological data with the data concerning the number of exposed people, is an indispensable condition for assessing properly the trend in Lyme disease incidence rates, concerning at the same time a real scale of occupational exposure...
March 24, 2017: Medycyna Pracy
https://www.readbyqxmd.com/read/28345481/cost-effectiveness-analysis-of-implementing-an-antimicrobial-stewardship-programme-in-critical-care-units
#10
Jesus Ruiz-Ramos, Juan Frasquet, Eva Romá, Jose Luis Poveda-Andres, Miguel Salavert-Leti, Alvaro Catellanos, Paula Ramirez
AIMS: To evaluate the cost-effectiveness of antimicrobial stewardship (AS) programme implementation focused on critical care units based on assumptions for the Spanish setting. MATERIAL AND METHODS: A decision model comparing costs and outcomes of sepsis, community-acquired pneumonia, and nosocomial infections (including catheter-related bacteremia, urinary tract infection, and ventilator-associated pneumonia) in critical care units with or without an AS was designed...
March 26, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28345440/the-economic-burden-of-opioid-abuse-updated-findings
#11
Noam Y Kirson, Lauren M Scarpati, Caroline J Enloe, Aliya P Dincer, Howard G Birnbaum, Tracy J Mayne
BACKGROUND: Opioid pain relievers can be highly effective in providing relief for patients suffering from pain. At the same time, prescription opioid abuse, dependence, overdose, and poisoning (hereinafter "abuse") have become a national public health concern. Opioid abuse is also costly: previous estimates of the annual excess costs of opioid abuse to payers range from approximately $10,000 to $20,000 per patient. OBJECTIVES: To (a) provide a comprehensive, current estimate of the economic burden of opioid abuse to commercial payers and (b) explore the drivers of these excess costs of abuse...
April 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28345210/geographic-disparities-in-availability-of-opioid-use-disorder-treatment-for-medicaid-enrollees
#12
Amanda J Abraham, Christina M Andrews, Marissa E Yingling, Jerry Shannon
OBJECTIVE: To examine county-level geographic variation in treatment admissions among opioid treatment programs (OTPs) that accept Medicaid in the continental United States. DATA SOURCES/STUDY SETTING: Data come from the 2012 National Survey of Substance Abuse Treatment Services. STUDY DESIGN/DATA COLLECTION: We used local measures of spatial autocorrelation (LISA) analysis to identify (1) clusters of counties with higher and lower than average rates of opioid use disorders and (2) clusters of counties with higher and lower than average treatment admissions among OTPs that accept Medicaid, adjusting for county population size...
March 27, 2017: Health Services Research
https://www.readbyqxmd.com/read/28345169/alcohol-use-from-adolescence-through-early-adulthood-an-assessment-of-measurement-invariance-by-age-and-gender
#13
Jessica N Fish, Amanda M Pollitt, John E Schulenberg, Stephen T Russell
BACKGROUND AND AIMS: Studies on alcohol use and related constructs rarely test for measurement invariance to assess the reliability and validity of measures of alcohol use across different subpopulations of interest or ages. This failure to consider measurement invariance may result in biased parameter estimates and inferences. This study aimed to test measurement invariance of alcohol use across gender and age using a US-nationally representative sample to inform future longitudinal studies assessing alcohol use...
March 26, 2017: Addiction
https://www.readbyqxmd.com/read/28345014/the-cigarette-and-smokeless-tobacco-markets-in-texas-relative-to-the-united-states
#14
Erin J Miller Lo, Daniel P Giovenco, Olivia A Wackowski, Melissa B Harrell, Cheryl L Perry, Cristine D Delnevo
OBJECTIVE: This study compares the cigarette and smokeless tobacco (SLT) markets in Texas and the United States (US) as a whole. METHODS: Nielsen convenience store sales data from 2014 were obtained for Dallas, Houston, San Antonio/Austin, and the total US. Descriptive statistics highlighted market share differences in Texas compared to the US overall. RESULTS: Marlboro and Copenhagen dominated the cigarette (58.9%) and SLT markets (44.8%) in Texas and had substantially higher relative market shares in Texas than nationally (46...
April 2017: Tobacco Regulatory Science
https://www.readbyqxmd.com/read/28344786/united-european-gastroenterology-evidence-based-guidelines-for-the-diagnosis-and-therapy-of-chronic-pancreatitis-hapaneu
#15
REVIEW
J Matthias Löhr, Enrique Dominguez-Munoz, Jonas Rosendahl, Marc Besselink, Julia Mayerle, Markus M Lerch, Stephan Haas, Fatih Akisik, Nikolaos Kartalis, Julio Iglesias-Garcia, Jutta Keller, Marja Boermeester, Jens Werner, Jean-Marc Dumonceau, Paul Fockens, Asbjorn Drewes, Gürlap Ceyhan, Björn Lindkvist, Joost Drenth, Nils Ewald, Philip Hardt, Enrique de Madaria, Heiko Witt, Alexander Schneider, Riccardo Manfredi, Frøkjer J Brøndum, Sasa Rudolf, Thomas Bollen, Marco Bruno
BACKGROUND: There have been substantial improvements in the management of chronic pancreatitis, leading to the publication of several national guidelines during recent years. In collaboration with United European Gastroenterology, the working group on 'Harmonizing diagnosis and treatment of chronic pancreatitis across Europe' (HaPanEU) developed these European guidelines using an evidence-based approach. METHODS: Twelve multidisciplinary review groups performed systematic literature reviews to answer 101 predefined clinical questions...
March 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/28343951/orthopedic-in-training-examination-a-performance-review-based-on-program-and-resident-specific-characteristics
#16
Christopher L Camp, Ryan M Degen, Norman S Turner, Arlen D Hanssen, Matthew D Karam, Joshua S Dines
OBJECTIVES: The orthopedic in-training examination (OITE) is the most common and objective method used to assess resident knowledge in the United States. As such, residents and programs use a number of strategies to maximize OITE performance. The purpose of this work was to better understand what strategies were being implemented and to determine which program-specific and resident-specific characteristics best correlate with improved scores. DESIGN: A national survey of orthopedic residents and program directors (PDs) was performed to better understand OITE performance and correlate scores with various test preparation strategies...
March 23, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28343600/comparison-of-late-mortality-among-twins-versus-singletons-with-congenital-heart-defects
#17
Anne Maria Herskind, Lisbeth Aagaard Larsen, Dorthe Almind Pedersen, Kaare Christensen
In 2014, in the United States, nearly 7% of newborns were twins. Congenital heart defects (CHDs) are more frequent in both monozygotic and dizygotic twins than in singletons. Still, the longer-term prognosis for CHD twins is unknown. Here we assess the mortality pattern for CHD twins up to age 36 years and compare it with that for non-CHD twins, non-CHD co-twins, and CHD singletons. We identified all twins and a 5% random sample of all singletons born in Denmark from 1977 to 2009 by linking Danish national population and health registers...
March 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28343597/national-trends-and-in-hospital-outcomes-in-pregnant-women-with-heart-disease-in-the-united-states
#18
Fabio V Lima, Jie Yang, Jianjin Xu, Kathleen Stergiopoulos
Investigation of trends and outcomes in heart disease (HD) and pregnancy has been limited. We chose to identify the prevalence, trends, and outcomes of pregnant women with different forms of HD in the United States. Healthcare Cost and Utilization Project's National Inpatient Sample was screened for hospital admissions for delivery in pregnant women with HD from 2003 to 2012. Maternal clinical characteristics and outcomes were identified in women with and without HD, and in HD subtypes: congenital (CHD), valvular HD, cardiomyopathy, and pulmonary hypertension (PH)...
February 28, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28343114/seeing-through-the-public-health-smoke-screen-in-drug-policy
#19
Joanne Csete, Daniel Wolfe
In deliberations on drug policy in United Nations fora, a consensus has emerged that drug use and drug dependence should be treated primarily as public health concerns rather than as crimes. But what some member states mean by "public health approach" merits scrutiny. Some governments that espouse treating people who use drugs as "patients, not criminals" still subject them to prison-like detention in the name of drug-dependence treatment or otherwise do not take measures to provide scientifically sound treatment and humane social support to those who need them...
March 23, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28342563/type-2-diabetes-mellitus-treatment-patterns-across-europe-a-population-based-multi-database-study
#20
Jetty A Overbeek, Edith M Heintjes, Daniel Prieto-Alhambra, Patrick Blin, Régis Lassalle, Gillian C Hall, Francesco Lapi, Elisa Bianchini, Niklas Hammar, Irene D Bezemer, Ron M C Herings
PURPOSE: The aim of this study was to determine the similarities and differences of type 2 diabetes mellitus (T2DM) treatment patterns in daily practice in 5 European countries and whether these reflect differences in guidelines. METHODS: Prescriptions for drugs used in diabetes treatment during a 5-year study period were obtained from electronic databases. Patients initiating T2DM treatment during the study period were included. An SAS analysis tool was developed to create episodes of use of drug classes, which resulted in treatment patterns...
March 22, 2017: Clinical Therapeutics
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