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https://www.readbyqxmd.com/read/29029245/host-transcription-profile-in-nasal-epithelium-and-whole-blood-of-hospitalised-children-under-two-years-of-age-with-respiratory-syncytial-virus-infection
#1
Lien Anh Ha Do, Johann Pellet, H Rogier van Doorn, Anh Tuan Tran, Bach Hue Nguyen, Thi Thu Loan Tran, Quynh Huong Tran, Quoc Bao Vo, Nguyen Anh Tran Dac, Hong Nhien Trinh, Thi Thanh Hai Nguyen, Bao Tinh Le Binh, Huu Mai Khanh Nguyen, Minh Tien Nguyen, Quang Tung Thai, Thanh Vu Vo, Ngoc Quang Minh Ngo, Thi Kim Huyen Dang, Ngoc Huong Cao, Thu Van Tran, Lu Viet Ho, Bertrand De Meulder, Charles Auffray, Jorrit-Jan Hofstra, Jeremy Farrar, Juliet E Bryant, Menno de Jong, Martin L Hibberd
Most insights into the cascade of immune events following acute respiratory syncytial virus (RSV) infection have been obtained from animal experiments or in vitro models. Here we investigated host gene expression profiles in nasopharyngeal swabs (NP) and whole blood samples during natural RSV and rhinovirus (hRV) infection (acute versus early recovery phase) in 83 hospitalised patients <2 years old with lower respiratory tract infections (LRTI). RSV infection induced strong and persistent innate immune responses including interferon signaling and pathways related to chemokine/cytokine signaling in both compartments...
September 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29029059/canonical-wnt-%C3%AE-catenin-signaling-regulates-postnatal-mouse-epididymal-development-but-does-not-affect-epithelial-cell-differentiation
#2
Manish Kumar, Pradeep S Tanwar
The epithelial lining of epididymis establishes an optimal environment in which spermatozoa acquire the ability to fertilize an oocyte. This highly specialized organ develops from a simple embryonic tube known as the Wolffian duct (WD). How the simple columnar epithelium of WD acquires the complex features of the adult epididymal epithelium is currently unclear. During these first few weeks after birth, the epididymal epithelium undergoes significant changes and by five weeks, consists of four different cell types...
October 5, 2017: Endocrinology
https://www.readbyqxmd.com/read/29028798/obstructive-sleep-apnea-and-rhonchopathy-are-associated-with-downregulation-of-trefoil-factor-family-peptide-3-tff3-implications-of-changes-in-oral-mucus-composition
#3
Regina Siber-Hoogeboom, Martin Schicht, Sebastian Hoogeboom, Friedrich Paulsen, Maximilian Traxdorf
STUDY OBJECTIVES: Trefoil factor family (TFF) peptides belong to the family of mucin-associated peptides and are expressed in most mucosal surfaces. TFF peptides carry out functions such as proliferation and migration enhancement, anti-apoptosis, and wound healing. Moreover, TFFs are associated with mucins and interact with them as "linker peptides", thereby influencing mucus viscosity. To test the hypothesis that in rhonchopathy and obstructive sleep apnea (OSA) changes occur in the expression of TFF3 and -2 that could contribute to changes in mucus viscosity, leading to an increase in upper airway resistance during breathing...
2017: PloS One
https://www.readbyqxmd.com/read/29028602/toxicity-of-zno-nanoparticles-nps-to-a549-cells-and-a549-epithelium-in-vitro-interactions-with-dipalmitoyl-phosphatidylcholine-dppc
#4
Tong He, Jimin Long, Juan Li, Liangliang Liu, Yi Cao
Once inhaled, nanoparticles (NPs) will first interact with lung surfactant system, which may influence the colloidal aspects of NPs and consequently the toxic potential of NPs to pulmonary cells. In this study, we investigated the effects of dipalmitoyl phosphatidylcholine (DPPC), the major component in lung surfactant, on stability and toxicity of ZnO NPs. The presence of DPPC increased the UV-vis spectra, hydrodynamic size, Zeta potential and dissolution rate of ZnO NPs, which indicates that DPPC might interact with NPs and affect the colloidal stability of NPs...
October 7, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29027839/ephb-receptors-mainly-ephb3-contribute-to-the-proper-development-of-cortical-thymic-epithelial-cells
#5
Sara Montero-Herradón, Javier García-Ceca, Agustín G Zapata
EphB and their ligands ephrin-B are an important family of protein tyrosine kinase receptors involved in thymocyte-thymic epithelial cell interactions known to be key for the maturation of both thymic cell components. In the present study, we have analyzed the maturation of cortical thymic epithelium in EphB-deficient thymuses evaluating the relative relevance of EphB2 and EphB3 in the process. Results support a relationship between the epithelial hypocellularity of mutant thymuses and altered development of thymocytes, lower proportions of cycling thymic epithelial cells and increased epithelial cell apoptosis...
October 13, 2017: Organogenesis
https://www.readbyqxmd.com/read/29027700/increases-in-the-expression-of-na-h-exchanger-1-and-3-are-associated-with-insulin-signalling-in-the-ruminal-epithelium
#6
L Yan, Z Shen, Z Lu
Na(+) /H(+) exchanger (NHE), which catalyses the exchange of extracellular Na(+) for intracellular H(+) , is of importance in the maintenance of Na(+) and pH homoeostasis for rumen epithelial cells. Studies in ruminants showed that high concentrate diets could increase the expression of NHE in ruminal epithelium. Results of recent studies further indicated that insulin, as an important hormone closely related to dietary concentrate, could enhance the expression of NHE. In this study, we have investigated the mechanisms of insulin regulating the expression of NHE in rumen epithelial cells and its potential role in dietary modulation of NHE expression in ruminal epithelium of cows...
October 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29027524/-the-morphological-and-immunohistochemical-characteristics-of-stratified-mucin-producing-intraepithelial-lesion
#7
M V Shamarakova, A V Asaturova, L S Ezhova, M R Dumanovskaya, N M Faizullina, A V Kozachenko
Stratified mucin-producing intraepithelial lesion (SMILE) is a rare premalignant cervical lesion that combines the structural features of cervical intraepithelial neoplasia (CIN) and endocervical adenocarcinoma in situ (AIS). AIM: to analyze archival materials for the detection of SMILE and its subsequent morphological and immunohistochemical characterization. MATERIAL AND METHODS: Cervical cone specimens from 53 women with histologically verified CIN3 were examined...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/29027223/inflammatory-cell-death-in-intestinal-pathologies
#8
REVIEW
Deepika Sharma, Thirumala-Devi Kanneganti
The intestinal tract is a site of intense immune cell activity that is poised to mount an effective response against a pathogen and yet maintain tolerance toward commensal bacteria and innocuous dietary antigens. The role of cell death in gut pathologies is particularly important as the intestinal epithelium undergoes self-renewal every 4-7 days through a continuous process of cell death and cell division. Cell death is also required for removal of infected, damaged, and cancerous cells. Certain forms of cell death trigger inflammation through release of damage-associated molecular patterns...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29027062/congenital-ectropion-uveae-with-glaucoma-a-case-report
#9
Rashmi Kumari, Bhawesh Chandra Saha
Congenital ectropion uveae (CEU) is a rare anomaly characterized by ectropion uveae, iris hypoplasia, iridotrabecular dysgenesis and glaucoma. The apparent ectropion uveae results from the spread of iris pigment epithelium beyond the iris ruff and onto the anterior surface of the iris. Conclusion Open-angle glaucoma results due to angle dysgenesis, so patients should be carefully examined periodically for its early detection.
October 12, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29026699/comparison-of-the-clinical-biological-width-with-the-published-standard-histologic-mean-values
#10
Fatme Mouchref Hamasni, Fady El Hajj
AIMS AND OBJECTIVES: Biologic width (BW) as defined by Cohen is the part of the supracrestal gingival tissues that occupy the space between the base of the gingival crevice and the alveolar crest; it includes the junctional epithelium and the connective tissue element. Interactions between dental crowns and the marginal periodontal tissues analyzed in many review papers concluded that the recognition of the BW, in terms of crown margin placement, is beneficial for periodontal health. Therefore, knowledge of the dimensions of the sum of the junctional epithelium and connective tissue attachment as well as the sulcus depth (SD) is of clinical relevance...
September 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29026682/wavelength-dependent-optical-properties-of-melanosomes-in-retinal-pigmented-epithelium-and-their-changes-with-melanin-bleaching-a-numerical-study
#11
Weiye Song, Lei Zhang, Steve Ness, Ji Yi
In this paper, we present the first numerical study on full metrics of wavelength-dependent optical properties of melanosomes in retinal pigmented epithelial (RPE) cells. T-matrix method was used to simulate the spheroidal shapes of mature melanosomes, and the complex refractive index was calculated by a subtractive Kramers-Kronig relation for melanin. The validity of the method was first confirmed by Mie theory, and corroborated by a comparison between visible light and near infrared (NIR) optical coherence tomography (OCT) on human retinal imaging...
September 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29026649/unique-genome-organization-of-non-mammalian-papillomaviruses-provides-insights-into-the-evolution-of-viral-early-proteins
#12
Koenraad Van Doorslaer, Valeria Ruoppolo, Annie Schmidt, Amelie Lescroël, Dennis Jongsomjit, Megan Elrod, Simona Kraberger, Daisy Stainton, Katie M Dugger, Grant Ballard, David G Ainley, Arvind Varsani
The family Papillomaviridae contains more than 320 papillomavirus types, with most having been identified as infecting skin and mucosal epithelium in mammalian hosts. To date, only nine non-mammalian papillomaviruses have been described from birds (n = 5), a fish (n = 1), a snake (n = 1), and turtles (n = 2). The identification of papillomaviruses in sauropsids and a sparid fish suggests that early ancestors of papillomaviruses were already infecting the earliest Euteleostomi. The Euteleostomi clade includes more than 90 per cent of the living vertebrate species, and progeny virus could have been passed on to all members of this clade, inhabiting virtually every habitat on the planet...
July 2017: Virus Evolution
https://www.readbyqxmd.com/read/29026201/dual-contribution-of-trpv4-antagonism-in-the-regulatory-effect-of-vasoinhibins-on-blood-retinal-barrier-permeability-diabetic-milieu-makes-a-difference
#13
David Arredondo Zamarripa, Ramsés Noguez Imm, Ana María Bautista Cortés, Osvaldo Vázquez Ruíz, Michela Bernardini, Alessandra Fiorio Pla, Dimitra Gkika, Natalia Prevarskaya, Fernando López-Casillas, Wolfgang Liedtke, Carmen Clapp, Stéphanie Thébault
Breakdown of the blood-retinal barrier (BRB), as occurs in diabetic retinopathy and other chronic retinal diseases, results in vasogenic edema and neural tissue damage, causing vision loss. Vasoinhibins are N-terminal fragments of prolactin that prevent BRB breakdown during diabetes. They modulate the expression of some transient receptor potential (TRP) family members, yet their role in regulating the TRP vanilloid subtype 4 (TRPV4) remains unknown. TRPV4 is a calcium-permeable channel involved in barrier permeability, which blockade has been shown to prevent and resolve pulmonary edema...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025733/hydrogen-sulfide-an-agent-of-stability-at-the-microbiome-mucosa-interface
#14
John L Wallace, Jean-Paul Motta, Andre G Buret
A diverse range of effects of the intestinal microbiota on mucosal defence and injury has become increasingly clear over the past decade. Hydrogen sulfide (H2S) has emerged as an important mediator of many physiological functions, including gastrointestinal mucosal defence and repair. Hydrogen sulfide is produced gastrointestinal tract tissues and by bacteria residing within the gut, and can influence the function of a wide range of cells. The microbiota also appears to be an important target of hydrogen sulfide...
October 12, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29025732/rack1-maintains-intestinal-homeostasis-by-protecting-the-integrity-of-the-epithelial-barrier
#15
Zhuan-Fen Cheng, Christine A Cartwright
Previously we generated mouse models of Rack1 deficiency to identify key functions for Rack1 in regulating growth of intestinal epithelia: suppressing crypt cell proliferation and regeneration, promoting differentiation and apoptosis, and repressing development of neoplasia. However, other than low body weight, we did not detect an overt phenotype in mice constitutively deleted of Rack1 in intestinal epithelia (vil-Cre:Rack1(fl/fl) mice), presumably because Rack1 was deleted in < 10% of the total surface area of the epithelia...
October 12, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29025379/survival-and-migration-of-adipose-derived-stem-cells-transplanted-in-the-injured-retina
#16
Hamid Aboutaleb Kadkhodaeian, Taki Tiraihi, Hamid Ahmadieh, Hossein Ziaei Ardakani, Narsis Daftarian, Taher Taheri
OBJECTIVES: Transplantation of stem cells is one of the approaches to treat retinal diseases. Our objective was to determine whether adipose-derived stem cell transplant can survive and migrate in the injured retina using a sodium iodate model for the pigmented retinal epithelium injury. MATERIALS AND METHODS: The adipose-derived stem cells were isolated from male albino Sprague-Dawley rats and labeled with DiI so as to track the transplants in the subretinal space...
October 12, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29025254/chromoblastomycosis-of-the-leg
#17
Akash Pramod Sali, Ayushi Sahay
We herein report a case of chromoblastomycosis presenting as a verrucous lesion over the leg. A 56-year-old male patient was a known case of carcinoma larynx and was treated for the same. At presentation to our hospital, the patient, in addition to the recurrent local disease, was suspected to have second primary in the form of verrucous carcinoma of the leg. Histopathological examination of the skin biopsy revealed the presence of characteristic pigmented sclerotic bodies with pseudoepitheliomatous hyperplasia of the overlying epithelium...
2017: Polish Journal of Pathology: Official Journal of the Polish Society of Pathologists
https://www.readbyqxmd.com/read/29025062/deletion-of-spata2-by-crispr-cas9n-causes-increased-inhibin-alpha-expression-and-attenuated-fertility-in-male-mice
#18
Ie Zhao, Jianjun Zhao, Guojin Xu, Zhijuan Wang, Jie Gao, Sheng Cui, Jiali Liu
As somatic cells in the testis seminiferous tubule, Sertoli cells provide the medium for spermatogenesis. One of the important functions of Sertoli cells is synthesizing and secreting cell factors to affect the production of sperm; however, much of those molecular regulation mechanisms remain unknown. Here, we confirm the localization of protein SPATA2, spermatogenesis-associated protein 2, which had previously been shown to be highly expressed in Sertoli cells of the adult mouse testis. To further conduct a functional study, we generated SPATA2 global knockout mice via use of the CRISPR/Cas9n gene editing technology...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29025060/adrenomedullin-improves-fertility-and-promotes-pinopodes-and-cell-junctions-in-the-peri-implantation-endometrium
#19
Brooke C Matson, Stephanie L Pierce, Scott T Espenschied, Eric Holle, Imani H Sweatt, Eric S Davis, Robert Tarran, Steven L Young, Trudy A Kohout, Marcel van Duin, Kathleen M Caron
Implantation is a complex event demanding contributions from both embryo and endometrium. Despite advances in assisted reproduction, endometrial receptivity defects persist as a barrier to successful implantation in women with infertility. We previously demonstrated that maternal haploinsufficiency for the endocrine peptide adrenomedullin (AM) in mice confers a sub-fertility phenotype characterized by defective uterine receptivity and sparse epithelial pinopode coverage. The strong link between AM and implantation suggested the compelling hypothesis that administration of AM prior to implantation may improve fertility, protect against complications, and ultimately lead to better maternal and fetal outcomes...
August 28, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29024547/equine-endometrial-explants-undergo-significant-degenerative-changes-in-culture
#20
Rose Schwinghamer, Alessandro Massolo, Cameron Knight, Claudia Klein
The current study evaluated equine endometrial explants following 12, 24, and 48 hours in culture. Measurement of an indicator of cell death in explant supernatant, light microscopy, and gene expression of biomarkers of endometrial function and cellular stress, were used to compare the effect of six different media on explant viability and morphology. Viability of explants was assessed indirectly through measuring LDH activity in the culture supernatant. Regardless of culture medium composition, a significant increase in LDH activity was observed within 12 hours of culture, indicating occurrence of cell damage...
October 12, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
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