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https://www.readbyqxmd.com/read/30025403/chemoprevention-with-enalapril-and-aspirin-in-men1-t-knockout-mouse-model
#1
Jerena Manoharan, Volker Fendrich, Pietro Di Fazio, Carmen Bollmann, Silvia Roth, Barbara Joos, Ioannis Mintziras, Max Albers, Annette Ramaswamy, Philippe Bertolino, Chang X Zhang, Emily P Slater, Detlef K Bartsch, Caroline Lopez-Lopez
<br>Pancreatic neuroendocrine neoplasias (pNEN) are the most common cause of death in adult patients with multiple endocrine neoplasia type 1 (MEN1). So far, only few chemopreventive strategies (e.g. with somatostatin analogues) have been evaluated for MEN1 associated pNENs. In this experimental study on 75 Men1(+ /T) knockout mice, the effect of aspirin (n=25) and an inhibitor of angiotensin-I converting enzyme (enalapril, n=25) compared to controls (n=25) were evaluated as single chemopreventive strategies for pNENs after 6,9,12,15 and 18 months...
July 19, 2018: Neuroendocrinology
https://www.readbyqxmd.com/read/30024857/jak2-v617f-promotes-venous-thrombosis-through-%C3%AE-1-%C3%AE-2-integrin-activation
#2
Bärbel Edelmann, Nibedita Gupta, Tina M Schnöder, Anja M Oelschlegel, Khurrum Shahzad, Jürgen Goldschmidt, Lars Philipsen, Sönke Weinert, Aniket Ghosh, Felix C Saalfeld, Subbaiah Chary Nimmagadda, Peter Müller, Rüdiger C Braun-Dullaeus, Juliane Mohr, Denise Wolleschak, Stefanie Kliche, Holger Amthauer, Florian H Heidel, Burkhart Schraven, Berend Isermann, Andreas Müller, Thomas Fischer
JAK2-V617F-positive chronic myeloproliferative neoplasia (CMN) is marked by dysfunction of integrins and adhesion molecules expressed on platelets, erythrocytes and leukocytes. However, the mechanism by which the two major leukocyte integrin chains, β1 and β2, mediate CMN pathophysiology remained unclear. β1 (α4β1; VLA-4) and β2 (αLβ2; LFA-1) integrins are essential regulators for attachment of leukocytes to endothelial cells. We here show enhanced adhesion of granulocytes from JAK2+/VF knock-in mice to vascular cell adhesion molecule 1 (VCAM1) and intercellular adhesion molecule 1 (ICAM1) coated surfaces...
July 19, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/30024715/beyond-colonic-neoplasia
#3
Elisa Gravito-Soares, Marta Gravito-Soares, Paulo Souto, João Fraga, Luis Tomé
No abstract text is available yet for this article.
April 2018: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/30024630/scurvy-as-cause-of-purpura-in-the-xxi-century-a-review-on-this-ancient-disease
#4
M Antonelli, M L Burzo, G Pecorini, G Massi, R Landolfi, A Flex
OBJECTIVE: Scurvy is defined as a deficiency of ascorbic acid, which is an essential exogenous vitamin in humans. Vitamin C is involved in collagen synthesis and its deficit can cause disorders of connective tissue. The most frequent symptoms are weakness, arthralgias, anorexia and depression, commonly associated with follicular hyperkeratosis and perifollicular hemorrhage, with purpura. PATIENTS AND METHODS: A young woman, with a history of malnutrition, manifested purpura and hematoma of the left lower limb...
July 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/30024517/the-diagnostic-accuracy-of-a-real-time-optoelectronic-device-in-cervical-cancer-screening-a-prisma-compliant-systematic-review-and-meta-analysis
#5
Huixia Yang, Xinmiao Zhang, Zengping Hao
BACKGROUND: This study aimed to assess the diagnostic accuracy of a real-time optoelectronic device (TruScreen) for uterine cervical cancer screening. METHODS: On the basis of Preferred Reporting Items for Systematic Reviews and Meta-analyses (the PRISMA statement) we performed this systematic review and meta-analysis. We searched PubMed, EMBASE, the Cochrane Library, CNKI, CBM, and WanFang Data using medical subject headings (MeSH) and text words. Title/abstract screening, full text check, data extraction, and methodological quality assessment (with the QUADAS-2 tool) were performed by 2 reviewers independently...
July 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30024373/comparison-of-the-clinical-performance-of-omniplex-hpv-and-genefinder-hpv-for-the-detection-and-genotyping-of-human-papillomaviruses-in-cervical-specimens
#6
GeeHay Hong, Yun Guk Park, Han Wool Jin, Sam Kyu Choi, Hyun Young Chi, Woo Jae Cho, Joo Hee Lee, Sol Han, Sun Pyo Hong
PURPOSE: Human papillomavirus (HPV) infection in women is known to promote the development of cervical neoplasia. Specific HPV genotypes are more highly associated with disease, and therefore detection and genotyping of HPV infection is critical for preventing and effectively treating cervical cancer. Consequently, various assays using diverse technologies have been developed to detect HPV genotype. Recently the OmniPlex-HPV and GeneFinder HPV methods, based on PCR and Luminex xMAP liquid bead microarray technologies, were developed for the detection of 40 and 32 HPV genotypes, respectively...
July 17, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/30023061/use-of-volumetric-laser-endomicroscopy-for-determining-candidates-for-endoscopic-therapy-in-superficial-esophageal-squamous-cell-carcinoma
#7
Arvind J Trindade, Petros C Benias, Sumant Inamdar, Cathy Fan, Amrita Sethi, Norio Fukami, Allon Kahn, Michel Kahaleh, Iman Andalib, Divyesh V Sejpal, Arvind Rishi
Background: Accurate staging of superficial esophageal squamous cell cancer (ESCC) for endoscopic therapy is challenging. Optical coherence tomography (OCT) has been shown to be superior to high-resolution endoscopic ultrasound (EUS). Volumetric Laser Endomicroscopy (VLE), a second-generation OCT, has recently become commercially available. Objective: To assess if VLE can determine which patients with superficial ESSC can undergo endoscopic therapy. Methods: This is a multi-center retrospective study...
July 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/30022628/burden-of-cervical-neoplasia-in-mid-western-rural-nepal-a-population-based-study
#8
Niresh Thapa, Girishma Shrestha, Muna Maharjan, Deborah Lindell, Ninu Maskey, Rajiv Shah, Caiyun Ge, Hongbing Cai
OBJECTIVE: To assess the burden of cervical neoplasia in mid-western rural, Nepal using cytology, visual inspection with acetic acid (VIA) and visual inspection with Lugol's iodine (VILI). METHOD: A cross-sectional, population-based study was conducted. Total of 2,279 married, non-pregnant women aged 20-65 years participated in a screening clinic from May 2016 to January 2017. All eligible women completed self-report of socio-demographic and reproductive health data followed by screening tests...
April 18, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/30021906/kaposi-sarcoma-associated-herpesvirus-latency-locus-renders-b-cells-hyperresponsive-to-secondary-infections
#9
Sang-Hoon Sin, Anthony B Eason, Rachele Bigi, Yongbaek Kim, SunAh Kang, Kelly Tan, Tischan A Seltzer, Raman Venkataramanan, Hyowon An, Dirk P Dittmer
Kaposi Sarcoma-associated herpesvirus (KSHV) KSHV induces B cell hyperplasia and neoplasia such as multicentric Castleman's disease (MCD) and primary effusion lymphoma (PEL). To explore KSHV-induced B cell reprogramming in vivo , we expressed the KSHV latency locus, inclusive of all viral miRNAs, in B cells of transgenic mice in the absence of the inhibitory FcγRIIB receptor. The BALB/c strain was chosen as this is the preferred model to study B cell differentiation. The mice developed hyperglobulinemia, plasmacytosis, and B lymphoid hyperplasia...
July 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/30021166/neuron-specific-menin-deletion-leads-to-synaptic-dysfunction-and-cognitive-impairment-by-modulating-p35-expression
#10
Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y Huang, Huaxi Xu, Jie Zhang
Menin (MEN1) is a critical modulator of tissue development and maintenance. As such, MEN1 mutations are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. Although menin is abundantly expressed in the nervous system, little is known with regard to its function in the adult brain. Here, we demonstrate that neuron-specific deletion of Men1 (CcKO) affects dendritic branching and spine formation, resulting in defects in synaptic function, learning, and memory. Furthermore, we find that menin binds to the p35 promoter region to facilitate p35 transcription...
July 17, 2018: Cell Reports
https://www.readbyqxmd.com/read/30019233/-diagnostics-and-treatment-of-lacrimal-duct-diseases-a-structured-patient-centred-care-concept
#11
REVIEW
J Heichel, H-G Struck, A Glien
BACKGROUND: The cardinal symptom of lacrimal stenosis is epiphora and a subjective high level of discomfort due to continuous dacryorrhea. OBJECTIVE: The aim of the current paper is to present a structured review of common diagnostic and therapeutic strategies for lacrimal stenosis. MATERIALS AND METHODS: The most important diagnostic and therapeutic approaches are analysed using the existing literature and by reporting the authors' own experiences...
July 17, 2018: HNO
https://www.readbyqxmd.com/read/30019203/-revised-version-of-the-4th-edition-of-the-who-classification-of-malignant-lymphomas-what-is-new
#12
REVIEW
G Ott, W Klapper, A C Feller, M L Hansmann, P Möller, H Stein, A Rosenwald, F Fend
After 8 years, the WHO has now published the updated version of the 4th edition of the classification of hematopoietic and lymphoid tumors. This update provides a conceptual rewrite of existing entities as well as some new provisional entities and categories, particularly among the aggressive B‑cell lymphomas. Important new diagnostic categories include the high-grade B‑cell lymphomas, the large B‑cell lymphoma with IRF4 rearrangement, and the Burkitt-like lymphoma with 11q aberrations. Of particular importance, new concepts concerning the taxonomy and classification of early lymphoid lesions or precursor lesions are included, such as the in situ follicular neoplasia or the in situ mantle cell neoplasia...
July 17, 2018: Der Pathologe
https://www.readbyqxmd.com/read/30019093/correction-to-factors-predictive-of-complete-excision-of-large-colorectal-neoplasia-using-hybrid-endoscopic-submucosal-dissection-a-kasid-multicenter-study
#13
Yunho Jung, Jong Wook Kim, Jeong-Sik Byeon, Hoon Sup Koo, Sun-Jin Boo, Jun Lee, Young Hwangbo, Yoon Mi Jeen, Hyun Gun Kim
The original version of the article unfortunately contained errors in author affiliation. Affiliation of third and ninth author was incorrectly assigned.
July 17, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/30018902/clinical-factors-that-affect-diagnostic-discrepancy-between-colposcopically-directed-biopsies-and-loop-electrosurgical-excision-procedure-conization-of-the-uterine-cervix
#14
Yuyeon Jung, Ah Ra Lee, Sung-Jong Lee, Yong Seok Lee, Dong Choon Park, Eun Kyung Park
Objective: This study aimed to determine the factors affecting pathologic discrepancy and final diagnosis between colposcopic biopsy and pathology by loop electrosurgical excision procedure (LEEP). Methods: Between 2004 and 2016, 1,200 patients who underwent LEEP were enrolled for this study. 667 underwent cervical cytology, human papillomavirus (HPV) test, colposcopic biopsy, and LEEP. We analyzed patient's age, menopausal status, number of delivery, abortion times, cervical cytology, number of punch biopsies, HPV type, LEEP, and interval between colposcopic biopsy and LEEP...
July 2018: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/30017302/multiple-solid-pancreatic-lesions-prevalence-and-features-of-non-malignancies-on-dynamic-enhanced-ct
#15
Liang Zhu, Meng-Hua Dai, Shi-Tian Wang, Zheng-Yu Jin, Qiang Wang, Timm Denecke, Bernd Hamm, Hua-Dan Xue
OBJECTIVE: To determine the prevalence of multiple solid pancreatic lesions on dynamic enhanced CT performed for suspected pancreatic diseases, and to identify CT features of non-malignancies. METHODS: We investigated 8096 consecutive patients who underwent dynamic enhanced CT pancreas protocol at a tertiary center over 40 months. The final clinical /pathological diagnosis served as reference standard. The diagnostic accuracy of dynamic enhanced CT for non-malignancies was calculated...
August 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/30017146/cost-effectiveness-of-sex-neutral-hpv-vaccination-in-sweden-accounting-for-herd-immunity-and-sexual-behaviour
#16
Ellen Wolff, K Miriam Elfström, Hedda Haugen Cange, Sofie Larsson, Helene Englund, Pär Sparén, Adam Roth
INTRODUCTION: The aim was to assess cost-effectiveness of expanding the Swedish HPV-vaccination program to include preadolescent boys, by comparing health-effects and costs of HPV-related disease, with a sex-neutral vaccination program versus only vaccinating girls. METHODS: We used a dynamic compartmental model to simulate the burden of HPV16/18-related disease in Sweden, accounting for indirect effects of vaccination through herd-immunity. The model accounted for sexual behaviour, such as age preferences and men who have sex with men...
July 14, 2018: Vaccine
https://www.readbyqxmd.com/read/30017111/multiple-endocrine-neoplasia-in-children-and-the-importance-of-screening-part-2
#17
Kate Davies
No abstract text is available yet for this article.
July 12, 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/30016957/efficacy-effectiveness-and-safety-of-vaccination-against-human-papillomavirus-in-males-a-systematic-review
#18
Thomas Harder, Ole Wichmann, Stefanie J Klug, Marianne A B van der Sande, Miriam Wiese-Posselt
BACKGROUND: Human papillomavirus (HPV) vaccination is safe and effective in preventing cervical cancer in females. As HPV infections can also induce cancers of the anus, penis and oral cavity, male vaccination is also advocated, but systematic reviews on efficacy and safety in males are lacking. METHODS: We performed a systematic review on the efficacy, effectiveness and safety of HPV vaccination in males of any age. MEDLINE, Embase, the Cochrane Central Register of Controlled Trials and ClinicalTrials...
July 18, 2018: BMC Medicine
https://www.readbyqxmd.com/read/30016349/nmr-based-metabolic-profiling-of-urine-serum-fecal-and-pancreatic-tissue-samples-from-the-ptf1a-cre-lsl-krasg12d-transgenic-mouse-model-of-pancreatic-cancer
#19
Michelle J Schmahl, Daniel P Regan, Adam C Rivers, William C Joesten, Michael A Kennedy
Pancreatic cancer is the third leading cause of cancer deaths in the United States with more than 53,000 expected to be diagnosed with the disease in 2018. The median survival time after diagnosis is four to six months. The poor survival statistics are due in part to the fact that pancreatic cancer is typically asymptomatic until it reaches advanced stages of the disease. Although surgical resection provides the best chance of survival, pancreatic cancer is rarely detected when surgery is still possible due, in part, to lack of effective biomarkers for early detection...
2018: PloS One
https://www.readbyqxmd.com/read/30013718/persistent-increased-frequency-of-genomic-instability-in-women-diagnosed-with-breast-cancer-before-during-and-after-treatments
#20
Márcia Fernanda Correia Jardim Paz, André Luiz Pinho Sobral, Jaqueline Nascimento Picada, Ivana Grivicich, Antonio Luiz Gomes Júnior, Ana Maria Oliveira Ferreira da Mata, Marcus Vinícius Oliveira Barros de Alencar, Rodrigo Mendes de Carvalho, Kátia da Conceição Machado, Muhammad Torequl Islam, Ana Amélia de Carvalho Melo Cavalcante, Juliana da Silva
This study aimed to evaluate DNA damage in patients with breast cancer before treatment (background) and after chemotherapy (QT) and radiotherapy (RT) treatment using the Comet assay in peripheral blood and the micronucleus test in buccal cells. We also evaluated repair of DNA damage after the end of RT, as well as the response of patient's cells before treatment with an oxidizing agent (H2 O2 ; challenge assay). Fifty women with a mammographic diagnosis negative for cancer (control group) and 100 women with a diagnosis of breast cancer (followed up during the treatment) were involved in this study...
2018: Oxidative Medicine and Cellular Longevity
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