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Alberto Larghi, Mihai Rimbaș, Andrea Tringali, Ivo Boškoski, Gianenrico Rizzatti, Guido Costamagna
Radiofrequency ablation (RFA) acts by delivering thermal energy within the tissue, the result of a high-frequency alternating current released from an active electrode, leading to coagulative necrosis and cellular death. Recently, a biliary catheter working on a guide-wire has been developed and a number of studies have been performed so far. The present paper provides a comprehensive review of the literature on the results of the use of RFA for the clinical management of patients with unresectable malignant biliary strictures, benign biliary strictures, and residual adenomatous tissue in the bile duct after endoscopic papillectomy...
November 16, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
Sruthi Babu, Daniel C Mockler, Lucia Roa-Peña, Agnieszka Szygalowicz, Nam W Kim, Sholeh Jahanfard, Shahram S Gholami, Richard Moffitt, John P Fitzgerald, Luisa F Escobar-Hoyos, Kenneth R Shroyer
There is a clinical need to identify novel biomarkers to improve diagnostic accuracy for the detection of urothelial tumors. The current study aimed to evaluate keratin 17 (K17), an oncoprotein that drives cell cycle progression in cancers of multiple anatomic sites, as a diagnostic biomarker of urothelial neoplasia in bladder biopsies and in urine cytology specimens. We evaluated K17 expression by immunohistochemistry in formalin-fixed, paraffin embedded tissue specimens of non-papillary invasive urothelial carcinoma (UC) (classical histological cases), high grade papillary UC (PUC-LG), low grade papillary UC (PUC-HG), papillary urothelial neoplasia of low malignant potential (PUNLMP), and normal bladder mucosa...
November 15, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Rodney John Hicks, Price Jackson, Grace Kong, Robert E Ware, Michael S Hofman, David A Pattison, Tim Akhurst, Elizabeth Drummond, Peter Roselt, Jason Callahan, Roger Price, Charmaine Jeffery, Emily Hong, Wayne Noonan, Alan Herschtal, Lauren J Hicks, Matthew Harris, Amos Hedt, Brett M Paterson, Paul Donnelly
Imaging of somatostatin receptor (SSTR) expression is an established technique for staging of neuroendocrine neoplasia (NEN) and determining the suitability of patients for peptide receptor radionuclide therapy (PRRT). PET/ CT utilizing 68 Ga-labeled somatostatin analogues (SSAs) is superior to earlier agents, but the rapid physical decay of the radionuclide poses logistic and regulatory challenges. 64 Cu has attractive physical characteristics for imaging and provides a diagnostic partner for the therapeutic radionuclide 67 Cu...
November 15, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Alena Chlumská, Petr Mukenšnabl, Tomáš Waloschek, Michal Zámečník
Columnar lined esophagus is a complication of long term gastroesophageal reflux disease and the main precursor of esophageal adenocarcinoma. Incomplete intestinal metaplasia in reflux esophagitis represents one of the most important risk factors for neoplastic transformation through the metaplasia-dysplasia-adenocarcinoma sequence. However, recent studies suggest that cardiac type mucosa also shows molecular abnormalities which are similar to those of incomplete intestinal metaplasia. Immunohistochemically, three types of esophageal dysplasia and adenocarcinoma are recognized: adenomatous-intestinal, hybrid/mixed and foveolar gastric types...
2018: Ceskoslovenská Patologie
Thomas Mettang, Markus Streit
Many systemic diseases go along with dermal involvement. Only a few of systemic diseases show characteristic skin derangements directly leading to the diagnosis of the underlying disease. Ten of these entities are described within this article. Some of these are autoimmune diseases, such as systemic lupus erythematodes, dermatomyositis or the anti-synthetase-syndrome. Others are genetic diseases with benign or malignant neoplasias (Peutz-Jeghers-syndrome, neurofibromatosis, tuberous sclerosis, Birt-Hogg-Dubé-syndrome, Cowden-syndrome)...
November 2018: Deutsche Medizinische Wochenschrift
B Callejón-Leblic, A Pereira-Vega, E Vazquez-Gandullo, J L Sánchez-Ramos, J L Gómez-Ariza, T García-Barrera
The high prevalence of lung cancer (LC) has triggered the search of biomarkers for early diagnosis of this disease. For this purpose the study of metabolic changes related to the development of lung cancer could provide interesting information about its early diagnosis. In this sense, chronic obstructive pulmonary disease (COPD), a disease associated with tumor development, is a comorbidity that increases the risk of onset and progression of lung neoplasia and has also to be considered in the study of pathology related to lung cancer...
November 12, 2018: Biochimie
(no author information available yet)
Neurofibromatosis type 1 (NF1, von Recklinghausen disease) is inherited in autosomal dominant way genetic disorder, with an incidence at birth 1:3000. It is one of the most common congenital disorders. It is characterized by café-au-lait spots, neurofibromas, and less common MPTST and gliomas of the optic nerve. It is caused by germline mutations of the NF1 gene, which acts as tumor suppressor. Inactivation of the gene leads to increased activation of the kinase pathways, and in consequence, uncontrolled proliferation of cells...
September 15, 2018: Neuro Endocrinology Letters
Dania Bucchi, Manuela Chiavarini, Fortunato Bianconi, Maria E Galeotti, Alessio Gili, Fabrizio Stracci
Cervical cancer (CC) control is based on the implementation of effective screening programs. In the coming years, human papilloma virus vaccination coverage will contribute considerably toward cancer prevention. In Italy, where an organized screening program has been implemented, immigration from low/middle-income countries with a high prevalence of human papilloma virus infections has increased steadily over the last decades. To assess the impact of screening efforts in counteracting background changes, we analyzed the incidence trends of cervical intraepithelial neoplasia grade 3 carcinomas in situ (CIS) and invasive CC from 1994 to 2013 through an Age-Period-Cohort model using data of a regional population-based registry...
November 13, 2018: European Journal of Cancer Prevention
Liying Zhu, Nenghong Yang, Guiqin Du, Chengcheng Li, Guoqi Liu, Shengju Liu, Yongjie Xu, Yanan Di, Wei Pan, Xing Li
Colorectal neoplasia differentially expressed (CRNDE) is a significantly upregulated long noncoding RNA in hepatocellular carcinoma (HCC). CRNDE could promote cell proliferation, migration, and invasion, while its molecular mechanisms were still largely unclear. In this study, we investigated the expression and function of CRNDE. CRNDE was significantly upregulated in tumor tissues compared with adjacent normal tissues. In vitro, we revealed that knockdown of CRNDE inhibited cell proliferation, migration, and cell invasion capacities in HCC...
November 14, 2018: Journal of Cellular Biochemistry
Hamza Ichaoui, Ahmed Saadi, Marouene Chakroun, Haroun Ayed, Abderrazak Bouzouita, Mohammed Cherif, Amine Derouiche, Mohammed Riadh Ben Slama, Mohammed Chebil
INTRODUCTION: Xanthogranulomatous pyelonephritis (XGPN) is a particular form of chronic renal suppuration characterized by the destruction of renal parenchyma and its replacement by a granulomatous tissue containing xanthomatous cells. OBJECTIVE: To report and describe the main clinical, biological, radiological and therapeutic aspects of xanthogranulomatous pyelonephritis in adults in focal and diffuse forms. METHODS: This was a monocentric retrospective study involving 42 cases of XGPN operated and histologically confirmed between 2005 and 2015...
August 2018: La Tunisie Médicale
Walid Zbiba, Nadia Ben Abdesslem, Emna Bouayed, Mouna Rekik
INTRODUCTION: Orbital metastases are rare and they are even rarer to be the first sign of the disease, which can lead to misdiagnosis and delay of management. OBSERVATION: Our patient consulted for a diplopia and a ptosis of the upper eyelid of the right eye since one month, without any other systemic symptoms. After ophthalmological examination and orbital tomography, the diagnosis of orbital metastasis was suspected. Lung cancer was revealed by thoracic tomography and confirmed by an anatomopahological examination...
June 2018: La Tunisie Médicale
Francesca Marini, Francesca Giusti, Maria Luisa Brandi
BACKGROUND: Multiple endocrine neoplasia (MEN1) is a rare inherited multi-tumour syndrome, affecting specific neuroendocrine organs and non-endocrine tissues with a variable spectrum of over 20 possible different combinations, caused by inactivating heterozygote mutations of the MEN1 gene. Disease onset, penetrance, clinical presentation, course and prognosis are all extremely variable, even among individuals bearing the same causative mutation, which doesn't allow prediction of the individual clinical phenotype (based on the specific result of the genetic test), thus compelling all patients and mutation carriers to undergo a common routine general screening program...
November 14, 2018: Orphanet Journal of Rare Diseases
Simbarashe Chinyowa, Joel M Palefsky, Zvavahera M Chirenje, Rudo Makunike-Mutasa, Marshall Munjoma, Godfrey I Muguti
BACKGROUND: HIV-infected individuals are at increased risk of anal cancer; in the majority of cases this is linked to human papillomavirus (HPV) infection. Anal cancer screening is not routinely offered in Zimbabwe. METHODS: A cross-sectional study was performed on 152 patients (88 females; 64 males) attending Opportunistic Infection Clinics at 2 tertiary hospitals between November 2014 and June 2015. Demographic data, immunological parameters and behavioural characteristics were collected...
November 14, 2018: BMC Public Health
Crystal D C Kamilaris, Fabio Rueda Faucz, Antonis Voutetakis, Constantine A Stratakis
Carney complex is a rare, autosomal dominant, multiple endocrine neoplasia and lentiginosis syndrome, caused in most patients by defects in the PRKAR1A gene, which encodes the regulatory subunit type 1α of protein kinase A. Inactivating defects of PRKAR1A lead to aberrant cyclic-AMP-protein kinase A signaling. Patients may develop multiple skin abnormalities and a variety of endocrine and non-endocrine tumors. Endocrine manifestations include primary pigmented nodular adrenocortical disease, that may cause Cushing syndrome, growth-hormone secreting pituitary adenoma or pituitary somatotropic hyperplasia which can result in acromegaly, as well as gonadal and thyroid tumors...
November 14, 2018: Experimental and Clinical Endocrinology & Diabetes
Costantino Ricci, Martina S Rossi, Roberta De Stefano, Michelangelo Fiorentino, Francesco Vasuri
CASE PRESENTATION: A 55-year-old man with a history of basaloid squamous cell carcinoma of the oropharynx with laterocervical lymph node metastases 6 years before (and treated with chemoradiation) presented with flank pain and hematuria. Computed tomography scan found a renal lesion, with radiological features more suspicious for primitive renal neoplasia. Histopathological and immunohistochemical examination after surgical excision revealed a basaloid squamous cell carcinoma involving renal parenchyma...
November 2018: Urologia
Sinja Kristiansen, Åke Svensson, Linda Drevin, Ola Forslund, Christian Torbrand, Carina Bjartling
Studies on risk factors for penile intraepithelial neoplasia have been small in size, have not distinguished penile intraepithelial neoplasia from invasive cancer, and have relied on self-reported information. This study investigated risk factors for penile intraepithelial neoplasia in a cohort of 580 penile intraepithelial neoplasia cases and 3,436 controls using information from 7 Swedish registers. Cases with penile intraepithelial neoplasia had increased odds ratios (ORs) for inflammatory skin diseases (14...
November 14, 2018: Acta Dermato-venereologica
Siddiq Ahmed, Muhammad Ali, Nurudeen Adegbite, Ram Vaidhyanath, Christopher Avery
Actinomycosis of the tongue is rare. It may be difficult to differentiate this infection clinically and radiologically from other tongue pathology especially neoplasia. We report a substantial tongue lesion which mimicked malignancy at presentation. The patient was treated successfully with 4 weeks of oral antibiotic therapy. It is also important that clinicians are aware of the radiological differential diagnosis of lingual actinomycosis.
February 2019: Radiology case reports
Jing Qian, Kaja Tikk, Korbinian Weigl, Yesilda Balavarca, Hermann Brenner
BACKGROUND: Despite evidence that inflammation and metabolism play a crucial role in colorectal carcinogenesis, there have been few studies on the association of inflammatory and metabolic protein biomarkers in various stages of colorectal carcinogenesis. METHODS: Ninety-two inflammatory and metabolic biomarkers were measured in plasma samples of participants of screening colonoscopy. Markers identified to be significantly associated with the presence of advanced colorectal neoplasia (ACN) in a discovery set (n = 204) were validated in an independent replication set (n = 422)...
November 14, 2018: British Journal of Cancer
Daniel Heudobler, Michael Rechenmacher, Florian Lüke, Martin Vogelhuber, Tobias Pukrop, Wolfgang Herr, Lina Ghibelli, Christopher Gerner, Albrecht Reichle
In most clinical trials, thiazolidinediones do not show any relevant anti-cancer activity when used as mono-therapy. Clinical inefficacy contrasts ambiguous pre-clinical data either favoring anti-tumor activity or tumor promotion. However, if thiazolidinediones are combined with additional regulatory active drugs, so-called 'master modulators' of tumors, i.e., transcriptional modulators, metronomic low-dose chemotherapy, epigenetically modifying agents, protein binding pro-anakoinotic drugs, such as COX-2 inhibitors, IMiDs, etc...
November 9, 2018: International Journal of Molecular Sciences
W Y Gu, X Tao, L L Zhang, L Wang, X R Zhou, Y Ning
Objective: To describe the clinicopathological features of synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN-FGT). Methods: The sample consisted of 7 cases of SMMN-FGT recorded from November 2014 to September 2017 at Obstetrics and Gynecology Hospital, Fudan University.PAP method was used in immunohistochemistry.Clinical histories were retrieved and pathological slides were reviewed. Results: The patients were 37 to 70 years old(mean 54 years old). All patients showed endometrial mucinous lesions associated with cervical lesions...
November 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
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