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Perla R Colunga-Pedraza, Gisela B Gomez-Cruz, Julia E Colunga-Pedraza, Guillermo J Ruiz-Argüelles
In 1963 Jean Bernard introduced the concept of "geographic hematology" and distinguished 2 branches, i.e., "ethnic hematology," which deals with differences between populations, and "environmental hematology," which considers factors such as food habits, infections, and others. Both of these branches have implications in the distribution of hematological diseases worldwide. In comparison with Caucasian populations, in Mexico a significantly higher prevalence of acute lymphoblastic, acute promyelocytic, and acute megakaryoblastic leukemias has been described...
September 18, 2018: Acta Haematologica
José F Ruiz-González, Elizabeth Guevara-Gutiérrez, Mercedes Hernández-Torres, Guillermo Solís Ledesma, Alberto Tlacuilo-Parra
Introducción: El carcinoma basocelular (CBC) es la neoplasia cutánea maligna más común. Objetivo: se investigó el riesgo de recurrencia y de nueva neoplasia cutánea maligna después del tratamiento de CBC. Método: Estudio retrospectivo. Fueron identificados los pacientes con diagnóstico histopatológico de CBC primario, de enero de 2007 a diciembre de 2009, y se revisaron los expedientes para investigar el número de recurrencias, la localización, el tipo de tratamiento y la variante histopatológica, determinando nuevas neoplasias cutáneas malignas...
2018: Cirugia y Cirujanos
David Martínez-Ramos, Laura Simón-Monterde, Consuelo Suelves-Piqueres, Raquel Queralt-Martí, Manuel Laguna-Sastre
El linfoma anaplásico de células grandes asociado a implantes mamarios (BIA-ALCL, breast implant associated-anaplastic large cell lymphoma) es una enfermedad infrecuente, pero el número de casos ha aumentado en los últimos años. Se puede presentar en la consulta del cirujano como un aumento del volumen mamario por derrame periprotésico o como masa capsular. El tratamiento de elección es la cirugía, con explante de las prótesis y exéresis de la cápsula periprotésica. El pronóstico, si el diagnóstico es precoz y el tratamiento es adecuado, es bueno...
2018: Cirugia y Cirujanos
Pilar Brito-Zerón, Belchin Kostov, Pedro Moral-Moral, Aleida Martínez-Zapico, Carmen Díaz-Pedroche, Guadalupe Fraile, Patricia Pérez-Guerrero, Eva Fonseca, Angel Robles, María P Vaquero-Herrero, María Andrés Calvo, María José Forner, Cesar Morcillo, José Larrañaga, Monica Rodriguez-Carballeira, Manuel Ruiz-Muñoz, Robert Hurtado-García, Sergio Prieto-González, Asun Aljibe Aguilar, Luis Caminal-Montero, Pilar Hernández-Jiménez, Cristina Rodríguez Fernández-Viagas, Pedro Castro, Victoria Morell Massó, Alejandra Flores-Chavez, Manuel Ramos-Casals
Objective: To characterize the etiologies and clinical features at diagnosis of patients with hemophagocytic lymphohistiocytosis (HLH) and correlate these baseline features with survival using an etiopathogenically guided multivariable model. Patients and Methods: The Spanish Group of Autoimmune Diseases HLH Study Group, formed in 2013, is aimed at collecting adult patients with HLH diagnosed in internal medicine departments between January 3, 2013, and October 28, 2017...
September 2018: Mayo Clinic proceedings. Innovations, quality & outcomes
Štěpán Suchánek, Tomáš Grega, Miroslav Zavoral
In developed countries, colorectal cancer represents one of the most common malignancy. Screening of colorectal cancer, as a tool of secondary prevention, lead to reduction of the incidence and mortality of this disease. It allows to capture not only the precancerous lesions, but also the earlier stages of colorectal cancer, which can be effectively treated. In the Czech Republic the National colorectal cancer screening program was launched in 2000. It is focused to asymptomatic individuals over 50 years old, who have a negative personal and family history of colorectal neoplasia...
2018: Vnitr̆ní Lékar̆ství
Lukáš Bajer, Pavel Wohl, Pavel Drastich
Primary sclerosing cholangitis (PSC) is a progressive disease of the biliary tree which represents one of the most frequent indications for orthotopic liver transplantation (OLTx) in developed countries. LTx is currently the only curative procedure for PSC. Concomitant inflammatory bowel disease (IBD) is present in approximately 70 % of patients with PSC. Such colitis in PSC has specific clinical and etiological features and is considered as a distinct phenotype of IBD often referred to as "PSC-IBD"...
2018: Vnitr̆ní Lékar̆ství
Jessica Viti, Mario Poljak, Anja Oštrbenk, Ramya Bhatia, Elia Alcañiz Boada, Alyssa M Cornall, Kate Cuschieri, Suzanne Garland, Lan Xu, Marc Arbyn
BACKGROUND: Robust clinical and analytical validation of human papillomavirus (HPV) tests is a pre-requisite for their use in cervical cancer screening given the transience of most high-risk HPV infections. OBJECTIVES: To evaluate the EUROArray HPV test (PCR-based full HPV genotyping test) using the international validation of the VALGENT framework, which offers an opportunity to determine analytical and clinical performance according to internationally accepted performance metrics...
September 10, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Darrel A Cook, Laurie W Smith, Jennifer H Law, Wendy Mei, Lovedeep Gondara, Dirk J van Niekerk, Kathy M Ceballos, Dan Jang, Max Chernesky, Eduardo L Franco, Gina S Ogilvie, Andrew J Coldman, Mel Krajden
BACKGROUND: HPV FOCAL is a randomized trial comparing high-risk HPV [Hybrid Capture 2 (HC2)] vs. liquid-based cytology (LBC) for primary cervical screening. OBJECTIVE: The present study objective was to compare Aptima HPV (AHPV) and HC2 assay performance at the intervention arm baseline and 48 mo. screens in relation to the rates of cervical intraepithelial neoplasia (CIN) grade 2 or worse (CIN2+). STUDY DESIGN: Women enrolled after December 2010 (n = 3475) were screened at baseline with both AHPV and HC2 (AHPV was blinded)...
September 10, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
Stephanie S Liu, Karen Kl Chan, Daniel Kh Chu, Tina N Wei, Lesley Sk Lau, Siew F Ngu, Mandy My Chu, Ka Yu Tse, Philip Pc Ip, Enders Ko Ng, Annie Ny Cheung, Hextan Ys Ngan
Cervical cancer is one of the leading causes of cancer death in women globally, despite widespread use of cytology/Human Papillomavirus (HPV) screening. Here, we aimed to identify the potential role of miRNA as diagnostic biomarker in the detection of cervical pre-malignant lesions and cancer. In total, we recruited 582 patients with cervical diseases and 145 control individuals. The expression levels of six miRNAs (miR-20a, miR-92a, miR-141, miR-183*, miR-210 and miR-944) were found to be significantly up-regulated in cervical cancer and pre-malignant lesions as compared to normal cervical samples, indicating that they are oncogenic miRNAs...
September 17, 2018: Molecular Oncology
Cao Qiaoqiao, Honghui Li, Xue Liu, Zhengui Yan, Meng Zhao, Zhongjin Xu, Zhonghua Wang, Kerong Shi
MiR-24-3p, a broadly conserved, small, noncoding RNA, is abundantly expressed in mammary tissue. However, its regulatory role in this tissue remains poorly understood. It was predicted that miR-24-3p targets the 3' untranslated region (3'-UTR) of multiple endocrine neoplasia type 1 (MEN1), an important regulatory factor in mammary tissue. The objective of this study was to investigate the function of miR-24-3p in mammary cells. Using a luciferase assay in mammary epithelial cells (MAC-T), miR-24-3p was confirmed to target the 3'-UTR of MEN1...
September 17, 2018: Journal of Cellular Physiology
Lige Leng, Kai Zhuang, Zeyue Liu, Changquan Huang, Yuehong Gao, Guimiao Chen, Hui Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Hao Sun, Zhicheng Shao, Huifang Li, Kunkun Zhang, Wei Mo, Timothy Y Huang, Maoqiang Xue, Zengqiang Yuan, Xia Zhang, Guojun Bu, Huaxi Xu, Qi Xu, Jie Zhang
Astrocyte dysfunction and inflammation are associated with the pathogenesis of major depressive disorder (MDD). However, the mechanisms underlying these effects remain largely unknown. Here, we found that multiple endocrine neoplasia type 1 (Men1; protein: menin) expression is attenuated in the brain of mice exposed to CUMS (chronic unpredictable mild stress) or lipopolysaccharide. Astrocyte-specific reduction of Men1 (GcKO) led to depressive-like behaviors in mice. We observed enhanced NF-κB activation and IL-1β production with menin deficiency in astrocytes, where depressive-like behaviors in GcKO mice were restored by NF-κB inhibitor or IL-1β receptor antagonist...
September 6, 2018: Neuron
Roos E Pouw, Torsten Beyna, Kamar Belghazi, Arjun D Koch, Erik J Schoon, Rehan Haidry, Bas L Weusten, Raf Bisschops, Nicholas J Shaheen, Michael B Wallace, Norman Marcon, Rachel Heise-Ginsburg, Anniek W Gotink, Kenneth K Wang, Cadman L Leggett, Jacobo Ortiz-Fernández-Sordo, Krish Ragunath, Massimiliano DiPietro, Oliver Pech, Horst Neuhaus, Jacques J Bergman
BACKGROUND AND AIMS: Early neoplasia in Barrett's esophagus (BE) can be effectively and safely removed by endoscopic resection (ER) using multiband mucosectomy (MBM). This study aimed to document performance of a novel MBM device designed for improved visualization, easier passage of accessories, and better suction power compared with other marketed MBM devices. METHODS: This international, single-arm, prospective registry in 14 referral centers (Europe, 10; United States, 3; Canada, 1) included patients with early BE neoplasia scheduled for ER...
October 2018: Gastrointestinal Endoscopy
Q F Liang, J J Huang, K Cao, G Y Su, Z Q Wang, Y Zhang, B Li
Objective: To study the histopathology manifestation and imaging characteristics of in vivo confocal microscopy (IVCM) for diagnosis of ocular surface squamous neoplasia (OSSN) and analyze the reliability of IVCM in differential diagnosis from OSSN cases. Methods: A prospective study. Twenty-three patients (23 eyes) with OSSN were collected from September 2015 to November 2017 in Beijing Tongren Eye center. They were underwent the examinations sequentially as follows: visual examination; slit-lamp microscope examination and ocular surface photography; color fundus image; anterior segment optical coherence tomography examination; IVCM examination and histopathology examination after surgery...
September 11, 2018: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Christopher J Child, Alan G Zimmermann, George P Chrousos, Elisabeth Cummings, Cheri L Deal, Tomonobu Hasegawa, Nan Jia, Sarah Lawrence, Agnès Linglart, Sandro Loche, Mohamad Maghnie, Jacobo Pérez Sánchez, Michel Polak, Barbara Predieri, Annette Richter-Unruh, Ron G Rosenfeld, Diego Yeste, Tohru Yorifuji, Werner F Blum
Context: Safety concerns regarding premature mortality, diabetes, neoplasia and cerebrovascular disease in association with growth hormone (GH) therapy have been raised. Objective: To assess incidence of key safety outcomes. Design: Prospective, multinational, observational study (1999-2015). Setting: 22,311 GH-treated children from 827 investigative sites in 30 countries. Patients: Children with growth disorders...
September 13, 2018: Journal of Clinical Endocrinology and Metabolism
Annemiek Leeman, Renée M F Ebisch, Annemieke Kasius, Remko P Bosgraaf, David Jenkins, Miekel M van de Sandt, Lise M A de Strooper, Daniëlle A M Heideman, Peter J F Snijders, Leon F A G Massuger, Ruud L M Bekkers, Chris J L M Meijer, Folkert J van Kemenade, Wim G V Quint, Willem J G Melchers
OBJECTIVE: HPV16/18 genotyping and detection of hypermethylation of human cell genes involved in cervical oncogenesis have shown promising results in triage of high-risk HPV (hrHPV)-screen positive women on cervical smears. These tests can be performed on self-samples, which contain cervical and vaginal cells. We studied whether a self-sample represents the hrHPV type causing the worst cervical lesion and whether any differences in hypermethylation of FAM19A4/miR124-2 exist between CIN lesions caused by different hrHPV types...
September 12, 2018: Gynecologic Oncology
Claudia Teixeira da Costa Lodi, Márcia Antoniazi Michelin, Maria Inês Miranda Lima, Eddie Fernando Candido Murta, Letícia da Conceição Braga, Leticia Montes, Victor Hugo Melo
PURPOSE: Aberrant DNA methylation is present in virtually all types of human cancer. There is no clear evidence that methylation status can predict bad prognosis in patients with CIN recurrence in HIV infected. This study evaluates the relationship between aberrant methylation of CpG islands of CDH1, TIMP3 and MGMT genes and CIN recurrence in HIV-infected and -noninfected women. METHODS: This is a nested case-control study involving 33 cases with CIN recurrence and 114 controls without recurrence, HIV infected and noninfected, treated with LEEP, between 1999 and 2004...
September 14, 2018: Archives of Gynecology and Obstetrics
Carolina L Mercado, Cameron Pole, James Wong, Juan F Batlle, Fabiola Roque, Noah Shaikh, Juan C Murillo, Anat Galor, Carol L Karp
PURPOSE: To characterize vision-related and psychosocial quality of life (QoL) parameters in medically and surgically treated patients with OSSN. METHODS: Forty-one patients with OSSN treated with medical therapy consisting of interferon alpha 2b drops 1 MIU/ml (n = 22) or who underwent surgical excision (n = 19) were contacted. All subjects answered a quality of life assessment with an original questionnaire in which they were asked about a range of parameters...
September 11, 2018: Ocular Surface
Michela Giuliani, Pierluigi Rinaldi, Rossella Rella, Anna D'Angelo, Giorgio Carlino, Amato Infante, Maurizio Romani, Enida Bufi, Paolo Belli, Riccardo Manfredi
To develop a predictive scoring system for ultrasound-detected B3 lesions at ultrasound-guided core needle biopsy (US-CNB). A total of 2724 consecutive US-CNBs performed in our Institution (January 2011 to December 2014) were retrospectively reviewed. Inclusion criteria were as follows: (a) histopathological examination of the entire lesion or (b) availability of radiologic follow-up (FUP) ≥24 months. Patient- and lesion-related variables-patients' age, lesion consistency, lesion size, vascularization, BI-RADS category, and US-CNB result-were analyzed...
September 14, 2018: Breast Journal
Urska Ivanus, Tine Jerman, Alenka Repse Fokter, Iztok Takac, Veronika Kloboves Prevodnik, Mateja Marcec, Ursula Salobir Gajsek, Maja Pakiz, Jakob Koren, Simona Hutter Celik, Kristina Gornik Kramberger, Ulrika Klopcic, Rajko Kavalar, Simona Sramek Zatler, Biljana Grcar Kuzmanov, Mojca Florjancic, Natasa Nolde, Srdjan Novakovic, Mario Poljak, Maja Primic Zakelj
Background To overcome obstacles within the Slovenian organised cervical cancer screening programme, a randomised pilot study of human papillomavirus (HPV) self-sampling among non-attenders was performed, aiming to assess three different screening approaches. Participants and methods Non-attenders aged 30-64 years from two Slovenian regions were randomised to two HPV self-sampling groups-the opt-in (I1, n = 14.400) and the opt-out (I2, n = 9.556), with a control group (P, n = 2.600). Self-collected samples were analysed using the Hybrid Capture 2 assay...
September 14, 2018: Radiology and Oncology
Dima A Hammoud, Afroditi Boulougoura, Georgios Z Papadakis, Jing Wang, Lori E Dodd, Adam Rupert, Jeanette Higgins, Gregg Roby, Dorinda Metzger, Elizabeth Laidlaw, JoAnn M Mican, Alice Pau, Silvia Lage, Chun-Shu Wong, Andrea Lisco, Maura Manion, Virginia Sheikh, Corina Millo, Irini Sereti
Background: Immune reconstitution inflammatory syndrome (IRIS) represents an unexpected inflammatory response shortly after initiation of antiretroviral therapy (ART) in some human immunodeficiency virus (HIV)-infected patients with underlying neoplasia or opportunistic infections, including tuberculosis. We hypothesized that IRIS is associated with increased glycolysis and that 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) could help identify high-risk subjects...
September 11, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
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