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computed tomography perfusion

Visa Suomi, Bradley Treeby, Jiri Jaros, Jani Saunavaara, Aida Kiviniemi, Roberto Blanco
Therapeutic ultrasound is an investigational modality which could potentially be used for minimally invasive treatment of prostate cancer. Computational simulations were used to study the effect of natural physiological variations in tissue parameters on the efficacy of therapeutic ultrasound treatment in the prostate. The simulations were conducted on a clinical ultrasound therapy system using patient computed tomography (CT) data. The values of attenuation, perfusion, specific heat capacity and thermal conductivity were changed within their biological ranges to determine their effect on peak temperature andthermal dose volume...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Tyler J Loftus, Mauricio Pipkin, Tiago Machuca, Olusola Oduntan
INTRODUCTION: Posterior mediastinal masses present unique diagnostic and therapeutic challenges, particularly when large highly vascularized tumors extend toward or emanate from the spinal cord. The rare nature of these tumors precludes the development of standardized management algorithms, underscoring the importance of case reports. PRESENTATION OF CASE: A 57 year old female presented with exertional dyspnea and right chest pressure. Chest radiography followed by computed tomography (CT) scan demonstrated a 13 cm posterior mediastinal mass involving the T7 vertebral body...
October 29, 2018: International Journal of Surgery Case Reports
M Fanta, D Fischerová, T Indrielle-Kelly, P Koliba, A Zdeňková, A Burgetová, J Vrbíková
Leydig cell tumours of the ovary are rare and represent a diagnostic challenge not only due to their sporadic incidence but also due to the seemingly normal imaging. We present three cases of pre- and postmenopausal women who were presented with severe clinical signs of hyperandogenism where modern imaging modalities (including computed tomography (CT), magnetic resonance imaging (MRI) and positron-emission tomography combined with computed tomography (PET-CT)) failed to identify the tumour. Two patients underwent non-expert ultrasound, CT and MRI examination with uniform conclusion that ovaries are of normal appearance...
November 14, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Jelena Djokić Kovač, Aleksandra Đurić-Stefanović, Vladimir Dugalić, Ljubica Lazić, Dejana Stanisavljević, Danijel Galun, Dragan Mašulović
BACKGROUND: Pancreatic adenocarcinoma is a highly lethal disease even in initially resectable patients. Functional imaging procedures such as diffusion-weighted imaging (DWI) and computed tomography (CT)-perfusion might facilitate preoperative prediction of factors influencing prognosis in patients with pancreatic adenocarcinoma. PURPOSE: To evaluate CT-perfusion and DWI quantitative parameters of pancreatic adenocarcinoma and to assess their correlation with clinicopathological features...
November 14, 2018: Acta Radiologica
Nobuo Tomizawa, Shengpu Chou, Yusuke Fujino, Masaru Kamitani, Kodai Yamamoto, Shinichi Inoh, Takeshi Nojo, Kanako K Kumamaru, Shigeki Aoki, Sunao Nakamura
This article describes data related to a research article titled "Feasibility of dynamic myocardial CT perfusion using single-source 64-row CT", Tomizawa et al. (in press) [1]. Decrease in the myocardial blood flow could be calculated by performing stress dynamic computed tomography perfusion. This article compares the receiver operating characteristics curve of computed tomography angiography and dynamic myocardial perfusion to diagnose significant stenosis by invasive coronary angiography.
December 2018: Data in Brief
Fabian Morsbach, Yi-Hua Zhang, Lena Martin, Catarina Lindqvist, Torkel Brismar
OBJECTIVE: Although computed tomography (CT) is frequently used to determine body composition, the effects of using different CT protocols is not well known. The aim of this study was to determine whether contrast media phase, radiation dose, and slice thickness in CT affect body composition segmentation. METHODS: Clinically indicated perfusion CTs of the upper abdomen in 20 patients (seven women) between 40 and 87 y of age with high suspicion of hepatocellular carcinoma were analyzed retrospectively...
August 9, 2018: Nutrition
Catherine Stamoulis, Jack Connolly, Erika Axeen, Himanshu Kaulas, Jeffrey Bolton, Katherine Dorfman, Jonathan J Halford, Frank Duffy, Ted Treves, Phillip Pearl
OBJECTIVE: More than one third of children with epilepsy have medically intractable seizures. Promising therapies, including targeted neurostimulation and surgery, depend on accurate localization of the epileptogenic zone. Ictal perfusion Single-Photon Emission Computed Tomography (SPECT) can localize the seizure focus noninvasively, with comparable accuracy to that of invasive EEG. However, multiple factors including seizure dynamics may affect its spatial specificity. METHODS: Using subtracted ictal from interictal SPECT and scalp EEG from 118 pediatric epilepsy patients (40 of whom had surgery after the SPECT studies), information theoretic measures of association and advanced statistical models, this study investigated the impact of preictal and ictal brain network dynamics on SPECT focality...
November 9, 2018: IEEE Transactions on Bio-medical Engineering
Feifei Zhang, Yi Tian, Wei Yang, Xiaoliang Shao, Jianfeng Wang, Shengdeng Fan, Xiaoxia Li, Hui Yan, Xiaosong Wang, Yuetao Wang
BACKGROUND: Left ventricular mechanical dyssynchrony (LVMD) is closely associated with left ventricular dysfunction and poor prognosis in patients with acute myocardial infarction (AMI). However, whether mechanical dyssynchrony is present in the noninfarcted areas remains controversial. This research aimed to quantitatively evaluate the global and regional mechanical dyssynchrony early after AMI by phase analysis of single-photon emission computed tomography (SPECT) gated myocardial perfusion imaging (GMPI) and to further explore the related influencing factors...
November 8, 2018: Nuclear Medicine Communications
Daniella F Pinho, Amit Banga, Fernando Torres, Dana Mathews
Lung transplantation is an established treatment for patients with a variety of advanced lung diseases. Imaging studies play a valuable role not only in evaluation of patients prior to lung transplantation, but also in the follow up of patients after transplantation for detection of complications. After lung transplantation, complications can occur as a result of surgical procedure, pulmonary embolism and ultimately chronic lung allograft dysfunction. Lung scintigraphy, which includes physiologic assessment of lung ventilation and perfusion by imaging, has become an important procedure in the evaluation of these patients, assuming a complementary role to high resolution anatomic imaging (computed tomography [CT]), as well as spirometry...
October 23, 2018: Transplantation Reviews
Philippe Robin, Olivier Delcroix, Ronan Abgral, Pierre-Yves Le Roux, Pierre-Yves Salaun
RATIONALE: Ventilation/perfusion (V/Q) single-photon-emission computed tomography (SPECT) has arisen as an alternative to computed tomography pulmonary angiography (CTPA) in patients with pulmonary embolism (PE) suspicion. The addition of low dose CT (ldCT) to V/Q SPECT improves the specificity of the test, allowing for potential alternative diagnosis. PATIENT CONCERNS AND DIAGNOSIS: Here we presented a case of an aortic intramural hematoma (IMH) diagnosed on the ldCT portion of V/Q SPECT combined with CT...
October 2018: Medicine (Baltimore)
Nuno Martins, Ana Aires, Beatriz Mendez, Sandra Boned, Marta Rubiera, Alejandro Tomasello, Pilar Coscojuela, David Hernandez, Marián Muchada, David Rodríguez-Luna, Noelia Rodríguez, Jesús M Juega, Jorge Pagola, Carlos A Molina, Marc Ribó
Background: Determining the size of infarct extent is crucial to elect patients for reperfusion therapies. Computed tomography perfusion (CTP) based on cerebral blood volume may overestimate infarct core on admission and consequently include ghost infarct core (GIC) in a definitive lesional area. Purpose: Our goal was to confirm and better characterize the GIC phenomenon using CTP cerebral blood flow (CBF) as the reference parameter to determine infarct core. Methods: We performed a retrospective, single-center analysis of consecutive thrombectomies of middle cerebral or intracranial internal carotid artery occlusions considering noncontrast CT Alberta Stroke Program Early CT Score ≥6 in patients with pretreatment CTP...
October 2018: Interventional Neurology
Narayan Bhusal, Joyoni Dey, Jingzhu Xu, Kesava Kalluri, Arda Konik, Joyeeta M Mukherjee, P Hendrik Pretorius
PURPOSE: Single-Photon-Emission-Computed-Tomography (SPECT) is a non-invasive imaging modality, used in myocardial perfusion imaging. The challenges facing the majority of clinical SPECT systems are low sensitivity, poor resolution, and the relatively high radiation dose to the patient. New generation systems (GE Discovery, DSPECT) dedicated to cardiac imaging improve sensitivity by a factor of 5-8. This improvement can be used to decrease acquisition time and/or dose. But in the case of ultra-low dose (~3mCi) injections, acquisition times are still significantly long, taking 10-12 minutes...
November 8, 2018: Medical Physics
Davide Ippolito, Giulia Querques, Anna Pecorelli, Cammillo Talei Franzesi, Stefano Okolicsanyi, Mario Strazzabosco, Sandro Sironi
AIM: The aim of this study was to assess the role of dynamic contrast-enhanced perfusion computed tomography (pCT) imaging in the early detection of blood flow changes related to antiangiogenic treatment with sorafenib, in patients with advanced hepatocellular carcinoma (HCC), being the modified Response Evaluation Criteria in Solid Tumors (mRECIST) criteria the standard of reference. METHODS: Between 2012 and 2016, 43 cirrhotic patients (male, n = 39; female, n = 4) with biopsy-proven multifocal HCC underwent multi-detector-row computed tomography, and pCT examinations were performed before and every 2 months after sorafenib administration...
November 6, 2018: Journal of Computer Assisted Tomography
Sara Seitun, Cecilia De Lorenzi, Filippo Cademartiri, Angelo Buscaglia, Nicole Travaglio, Manrico Balbi, Gian Paolo Bezante
The past two decades have witnessed rapid and remarkable technical improvement of multidetector computed tomography (CT) in both image quality and diagnostic accuracy. These improvements include higher temporal resolution, high-definition and wider detectors, the introduction of dual-source and dual-energy scanners, and advanced postprocessing. Current new generation multidetector row (≥64 slices) CT systems allow an accurate and reliable assessment of both coronary epicardial stenosis and myocardial CT perfusion (CTP) imaging at rest and during pharmacologic stress in the same examination...
2018: BioMed Research International
Muhammad Hammadah, Jeong Hwan Kim, Ayman Samman Tahhan, Bryan Kindya, Chang Liu, Yi-An Ko, Ibhar Al Mheid, Kobina Wilmot, Ronnie Ramadan, Ayman Alkhoder, Fahad Choudhary, Mohamad Mazen Gafeer, Naser Abdelhadi, Pratik Pimple, Pratik Sandesara, Bruno B Lima, Amit J Shah, Laura Ward, Michael Kutner, J Douglas Bremner, David S Sheps, Paolo Raggi, Laurence S Sperling, Viola Vaccarino, Arshed A Quyyumi
Background: Many patients with coronary artery disease (CAD) are routinely referred for surveillance stress testing despite recommendations against it. Objective: To determine whether low levels of resting high-sensitivity cardiac troponin I (hs-cTnI) can identify persons without inducible myocardial ischemia. Design: Observational study. Setting: A university-affiliated hospital network. Patients: Persons with stable CAD: 589 in the derivation group and 118 in the validation cohort...
November 6, 2018: Annals of Internal Medicine
Ling Tan, Jun Xiao, Xinmin Zhou, Kangjun Shen, Feng Li, Jianguang Luo, Hao Tang
OBJECTIVE: To investigate the possible overlooked causes of early postoperative paraplegia, a severe complication of acute Stanford type A aortic dissection (ATAAD) after total arch replacement and frozen elephant trunk (FET). METHODS: We reviewed the clinical data and perioperative aortic computed tomography angiography records of 110 consecutive patients with ATAAD who underwent total arch replacement and FET (12 cm) between December 2014 and September 2017 and investigated the possible risk factors related to early postoperative paraplegia...
September 29, 2018: Journal of Thoracic and Cardiovascular Surgery
Lihua Chen, Xianchun Zeng, Youli Wu, Xiaochu Yan, Xuequan Huang, Hui Chen, Jiuquan Zhang, Jian Wang, Li Feng
BACKGROUND: The histological count of microvascular density (MVD) is the current clinical standard for assessing tumor angiogenesis. Although it is hypothesized that perfusion MRI can be a noninvasive alternative to MVD, there have been few studies to validate their correlations, particularly in lung cancer. PURPOSE: To investigate the correlation between MVD and perfusion parameters obtained from high-resolution GRASP (Golden-angle RAdial Sparse Parallel) dynamic contrast-enhanced (DCE)-MRI in a cohort of lung cancer patients, and to validate that GRASP MRI can serve as a free-breathing, noninvasive imaging approach for studying tumor angiogenesis...
November 3, 2018: Journal of Magnetic Resonance Imaging: JMRI
Teemu Maaniitty, Samuli Jaakkola, Antti Saraste, Juhani Knuuti
Aims: Recurrent chest pain after coronary artery bypass grafting (CABG) poses a diagnostic challenge. We hypothesized that combining anatomy of bypass grafts and native coronary arteries with ischaemia detection by hybrid imaging could be used to gain valuable and complementary information in patients with recurrent symptoms after CABG. Methods and results: We analysed 36 consecutive patients (67 ± 9 years, 81% male) who had undergone hybrid imaging using coronary computed tomography angiography (CCTA) and [15O]H2O positron emission tomography (PET) myocardial perfusion imaging due to recurrent symptoms after CABG...
November 2, 2018: European Heart Journal Cardiovascular Imaging
Salah Am Said, Aly Agool, Arno Hm Moons, Mounir Wz Basalus, Nils Rl Wagenaar, Rogier Lg Nijhuis, Jutta M Schroeder-Tanka, Riemer Hja Slart
AIM: To assess the functionality of congenital coronary artery fistulas (CAFs) using adenosine stress 13 N-ammonia positron emission tomography computed tomography (PET-CT). METHODS: Congenital CAFs were incidentally detected during coronary angiography (CAG) procedures in 11 adult patients (six males and five females) with a mean age of 64.3 years (range 41-81). Patients were collected from three institutes in the Netherlands. The characteristics of the fistulas (origin, pathway and termination), multiplicity of the origins and pathways of the fistulous vessels were assessed by CAG...
October 26, 2018: World Journal of Cardiology
Meivel Angamuthu, Madhavi Tripathi, Girish Parida, Vinay Goyal, Nishikant Damle, Chandrasekhar Bal
We report a 15-year-old girl referred to our department for a brain perfusion study with a diagnosis of Parry-Romberg syndrome with left hemifacial atrophy and left enophthalmos. In the presence of a normal magnetic resonance imaging, Tc-99m ECD brain perfusion revealed left temporal lobe hypoperfusion with preserved perfusion in rest of the cortical and subcortical regions and both cerebellar hemispheres.
October 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
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