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computed tomography perfusion

Koen Nieman
No abstract text is available yet for this article.
September 17, 2018: European Heart Journal Cardiovascular Imaging
Natalie C Lawrence, Samuel Kyle
INTRODUCTION: Ventilation perfusion single photon emission computed tomography (V/Q SPECT) and CTPA are the two leading imaging studies used to investigate acute pulmonary embolism. V/Q SPECT is often the first line investigation for pregnant patients and young females. Historically, V/Q Planar studies have high rates of indeterminate findings resulting in a preference for CTPA studies. The purpose of this research is to examine current V/Q SPECT referral practices in the quaternary clinical setting and to confirm V/Q SPECT studies have low rates of equivocal findings...
September 20, 2018: Journal of Medical Imaging and Radiation Oncology
Robert Novotny, Tomas Marada, Jaroslav Chlupac, Ondrej Viklicky, Jiri Fronek
Background: We report the case of a 43-year-old female patient with systemic lupus erythematosus, class III lupus nephritis, with predialysis creatinine levels around 350 μmol/L (3.95 mg/dL) after partial resection of the left kidney with histologically verified papillary carcinoma in 2010. Preoperative computed tomography of the abdomen revealed a small 8 mm tumor in the left upper kidney pole. The patient was indicated for simultaneous bilateral nephrectomy and orthotopic renal transplantation with the aim to minimize invasiveness of the procedure as well as for curable tumor removal...
2018: Research and Reports in Urology
Houman Sotoudeh
The recent approach to treat acute stroke is to extend treatment window in patients with salvageable peri-infarct ischemia which increases the application of the perfusion imaging, specifically computed tomography perfusion (CTP). In this paper, I am presenting a case of left middle cerebral artery infarction which was evaluated by CTP under "code stroke." The patient had an incidental spinal canal meningioma which was out of field of view in CTP but mimicked right cerebellar ischemia on CTP. Although ischemia has been previously reported within the peripheral parenchymal edema surrounding a meningioma, in this patient there was no evidence of edema in the right cerebellum on magnetic resonance imaging...
October 2018: Radiology Case Reports
Toshinori Totsugawa, Arudo Hiraoka, Kentaro Tamura, Hidenori Yoshitaka, Taichi Sakaguchi
Because of concerns about the high risk of perioperative complications, the feasibility of minimally invasive aortic valve replacement (MIAVR) for elderly patients remains controversial. Here, we review our results of MIAVR in octogenarians with aortic valve stenosis (AS). Between October 2012 and December 2017, 110 patients with AS underwent MIAVR via a right anterolateral mini-thoracotomy; 41 patients were octogenarian (Group O). The perioperative outcomes of these patients were compared with those of the 69 patients who were less than 80 years of age (Group Y)...
September 17, 2018: Heart and Vessels
Serdar Aslan, Mehmet Selim Nural, Ilkay Camlidag, Murat Danaci
PURPOSE: Multidetector computed tomography (MDCT) is routinely used in the diagnosis of pancreatic ductal adenocarcinoma (PDAC), but it may be inadequate in some cases, especially mass-forming chronic pancreatitis (MFCP) and isoattenuating pancreatic lesions. Perfusion CT (pCT) may help resolve this problem. The aim of this study was to evaluate whether pCT could help differentiating PDAC from MFCP and in characterization of isoattenuating pancreatic lesions. MATERIALS AND METHODS: This prospective study included 89 cases of pancreatic lesions detected by MDCT and further analyzed with pCT...
September 18, 2018: Abdominal Radiology
Qinshuo Zhao, Jingqiu Huang, Dong Wang, Liang Chen, Dating Sun, Chunxia Zhao
BACKGROUND: Myocardial infarction (MI) contributes to the development of cardiac remodeling and heart failure. Insufficient post-MI myocardial angiogenesis has been identified as a non-negligible event which precipitates heart failure progression. Previous studies reported that cytochrome P450 epoxygenase and its metabolites exerted beneficial effects on cardiovascular diseases. However, the role of cytochrome P450 2J2 (CYP2J2) in post-MI heart failure is incompletely understood. METHODS AND RESULTS: First, western blot and real-time PCR analyses showed that CYP2J2 expression increased clearly in patients with acute MI and old MI, compared to control...
September 13, 2018: Journal of Molecular and Cellular Cardiology
Csilla Celeng, Tim Leiner, Pál Maurovich-Horvat, Béla Merkely, Pim de Jong, Jan W Dankbaar, Hendrik W van Es, Brian B Ghoshhajra, Udo Hoffmann, Richard A P Takx
OBJECTIVES: This meta-analysis determined the diagnostic performance of coronary computed tomography (CT) angiography (CTA), CT myocardial perfusion (CTP), fractional flow reserve CT (FFRCT ), the transluminal attenuation gradient (TAG), and their combined use with CTA versus FFR as a reference standard for detection of hemodynamically significant coronary artery disease (CAD). BACKGROUND: CTA provides excellent anatomic, albeit limited functional information for the evaluation of CAD...
September 6, 2018: JACC. Cardiovascular Imaging
Beatrice Bassetti, Corrado Carbucicchio, Valentina Catto, Elisa Gambini, Erica Rurali, Alberto Bestetti, Giuseppe Gaipa, Daniela Belotti, Fabrizio Celeste, Matteo Parma, Stefano Righetti, Lorenza Biava, Maurizio Arosio, Alice Bonomi, Piergiuseppe Agostoni, Paolo Scacciatella, Felice Achilli, Giulio Pompilio
BACKGROUND: Cell therapy with bone marrow (BM)-derived progenitors has emerged as a promising therapeutic for refractory angina (RA) patients. In the present study, we evaluated the safety and preliminary efficacy of transcatheter delivery of autologous BM-derived advanced therapy medicinal product CD133+ cells (ATMP-CD133) in RA patients, correlating perfusion outcome with cell function. METHODS: In the phase I "Endocavitary Injection of Bone Marrow Derived CD133+ Cells in Ischemic Refractory Cardiomyopathy" (RECARDIO) trial, a total of 10 patients with left ventricular (LV) dysfunction (ejection fraction ≤ 45%) and evidence of reversible ischemia, as assessed by single-photon emission computed tomography (SPECT), underwent BM aspiration and fluoroscopy-based percutaneous endomyocardial delivery of ATMP-CD133...
September 14, 2018: Stem Cell Research & Therapy
Rahul D Renapurkar, Michael A Bolen, Sankaran Shrikanthan, Jennifer Bullen, Wadih Karim, Andrew Primak, Gustavo A Heresi
Background: The purpose of this study was to compare the qualitative and quantitative assessment of perfusion on dual-energy CT (DECT) and planar and single photon emission computed tomography (SPECT)-CT V/Q scanning in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Methods: Nineteen patients with known CTEPH underwent both DECT and SPECT-CT V/Q scanning. Sixteen of these patients underwent planar V/Q imaging concurrently. Two readers independently graded DECT-perfused blood volume (PBV) defects on a four-point scale (0= normal, 1= mild <25%, 2= moderate 25-50%, 3= severe >50%)...
August 2018: Cardiovascular Diagnosis and Therapy
Xing-Hui Li, Qi Liang, Tian-Wu Chen, Jian Wang, Xiao-Ming Zhang
Primary hepatocellular carcinoma (PHC) includes hepatocellular carcinoma, intrahepatic cholangiocarcinoma and other pathological types and is characterized by rapid progression. Most of the clinical diagnoses are made at late stage or when distant metastasis occurs, increasing the difficulty of treatment and resulting in a poor prognosis. Therefore, the early diagnosis of PHC plays an important role in timely treatment and the improvement of prognosis. The gold standard for the diagnosis of primary liver cancer is liver biopsy, but it has limitations as an invasive examination...
September 6, 2018: World Journal of Clinical Cases
Thomas Le Houérou, Dominique Fabre, Carlos G Alonso, Philippe Brenot, Ryiad Bourkaib, Claude Angel, Myriam Amsallem, Stephan Haulon
INTRODUCTION: The technique and preliminary outcomes are reported for laser fenestrated endografting (LfEVAR), developed as an alternative procedure for endovascular repair of thoraco-abdominal aortic aneurysms (TAAAs), type IA endoleaks (T1AELs), and pararenal aortic aneurysms (PAAAs). METHODS: Patients with TAAA, T1AEL, and PAAA considered unfit for open repair by a multidisciplinary team and who could not benefit from a custom made device were selected. LfEVAR is a physician modified technique requiring sequential steps...
September 2018: European Journal of Vascular and Endovascular Surgery
Kwon-Duk Seo, Sang Hyun Suh
PURPOSE: As endovascular therapy (EVT) has been approved as a treatment guideline for acute ischemic stroke (AIS), it has been increasing in Korea. We conducted a nationwide survey to evaluate the current status of EVT for patients with AIS in Korea. MATERIALS AND METHODS: An electronic survey was sent to a representative clinician at each hospital where EVT was available in Korea. A Google survey was used to distribute the questionnaires and receive responses from October 2017 to December 2017...
September 2018: Neurointervention
Lucía Fernández-Rodríguez, Isabel Torres, Delia Romera, Raúl Galera, Raquel Casitas, Elisabet Martínez-Cerón, Prudencio Díaz-Agero, Cristina Utrilla, Francisco García-Río
OBJECTIVES: The study objectives were to assess the accuracy of volumetric computed tomography to predict postoperative lung function in patients with lung cancer in relation to anatomic segments counting and perfusion scintigraphy, to generate specific predictive equations for each functional parameter, and to evaluate accuracy and precision of these in a validation cohort. METHODS: We assessed pulmonary functions preoperatively and 3 to 4 months postoperatively after lung resection for lung cancer (n = 114)...
August 2, 2018: Journal of Thoracic and Cardiovascular Surgery
George Bazoukis, Emmanouil S Brilakis, Gary Tse, Konstantinos P Letsas, Panagiotis Kitsoulis, Tong Liu, Adrian Baranchuk, Antonios Sideris, Costas Tsioufis, Stavros Stavrakis
OBJECTIVES: The aim of our systematic review was to investigate the efficacy of coronary sinus (CS) reducer device in patients with refractory angina. BACKGROUND: The CS reducer device provides a therapeutic option for patients with coronary artery disease who are not suitable for revascularization. METHODS: Two independent investigators (GB and GT) systematically searched the Medline and Cochrane library databases for studies describing the efficacy and safety of the CS reducer in patients with refractory angina from January 1, 2000 until May 12, 2018 using the following terms: "coronary sinus (reducer OR reducing) device...
September 7, 2018: Journal of Interventional Cardiology
Biqiu Tang, Jiaxin Zeng, Lu Liu, Yuan Xiao, Zhenlin Li, Kai Zhang, Shah Chandan, Youjin Zhao, Zheng Ye, Wenhao Wang, Li He, Su Lui
PURPOSE: The aim of this study was to evaluate the potential value of low-dose multimodal computed tomography (CT) in predicting prognosis of acute ischemic stroke (AIS) within 6 hours. METHODS: The admission "one-stop-shop" multimodal CT examination, including noncontrast CT (NCCT), low-dose CT perfusion, and CT angiography (CTA), was performed in patients with symptoms of stroke within 6 hours. Noncontrast CT, CTA source image (CTA-SI), cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transit time (MTT) maps were studied using Alberta Stroke Program Early CT Score (ASPECTS)...
September 4, 2018: Journal of Computer Assisted Tomography
Bing Wu, Nan Liu, Max Wintermark, Mark W Parsons, Hui Chen, Longting Lin, Shuai Zhou, Gang Hu, Yongwei Zhang, Jun Hu, Ying Li, Zihua Su, Xinhuai Wu, Guangming Zhu
Background and Purpose: Cerebral hemorrhage is a serious potential complication of stroke revascularization, especially in patients receiving intra-arterial tissue-type plasminogen activator (tPA) therapy. We investigated the optimal pre-intervention delay time (DT) of computed tomography perfusion (CTP) measurement to predict cerebral parenchymal hematoma (PH) in acute ischemic stroke (AIS) patients after intra-arterial tissue plasminogen activator (tPA) treatment. Methods: The study population consisted of a series of patients with AIS who received intra-arterial tPA treatment and had CTP and follow-up computed tomography/magnetic resonance imaging (CT/MRI) to identify hemorrhagic transformation...
2018: Frontiers in Neurology
Audrey Katako, Paul Shelton, Andrew L Goertzen, Daniel Levin, Bohdan Bybel, Maram Aljuaid, Hyun Jin Yoon, Do Young Kang, Seok Min Kim, Chong Sik Lee, Ji Hyun Ko
Utilizing the publicly available neuroimaging database enabled by Alzheimer's disease Neuroimaging Initiative (ADNI; ), we have compared the performance of automated classification algorithms that differentiate AD vs. normal subjects using Positron Emission Tomography (PET) with fluorodeoxyglucose (FDG). General linear model, scaled subprofile modeling and support vector machines were examined. Among the tested classification methods, support vector machine with Iterative Single Data Algorithm produced the best performance, i...
September 5, 2018: Scientific Reports
Kristen Smolinsky, Ivona Sediva
We present a 16-year-old female status post traumatic brain injury from severe motor vehicle crash with prolonged extrication. Initially with a Glasgow Coma Scale of 4 and blood pressure of 80/40, she required emergent intubation. Head computed tomography was notable for skull fracture with hematoma, diffuse axonal injury, and 6-mm midline shift with right uncal herniation. On hospital day 1, she underwent decompressive R hemicraniectomy. She received neuroprotective treatment including a hypocarbic, hypernatremic state with close blood pressure monitoring for appropriate cerebral perfusion...
2018: Child Neurology Open
Serdar Savas Gul, Serkan Gurgul, Murat Uysal, Fikret Erdemir
PURPOSE: The aim of the present study was to show the protective effect of pulsed magnetic field (PMF) application and melatonin administration on damage in testis in a one-sided torsion detorsion induced rat model using testicular scintigraphy with 99mTc pertechnetate, PET/CT with 18F-FDG and histopathological methods. MATERIALS AND METHODS: Sixty male rats were used in the study; 30 rats were randomly divided into five groups for one day applications of sham control, torsion, melatonin, pulsed magnetic field (PMF) and melatonin plus PMF...
September 1, 2018: Urology Journal
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