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computed tomography perfusion

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https://www.readbyqxmd.com/read/28646273/pulmonary-vascular-volume-ratio-measured-by-cardiac-computed-tomography-in-children-and-young-adults-with-congenital-heart-disease-comparison-with-lung-perfusion-scintigraphy
#1
Hyun Woo Goo, Sang Hyub Park
BACKGROUND: Lung perfusion scintigraphy is regarded as the gold standard for evaluating differential lung perfusion ratio in congenital heart disease. OBJECTIVE: To compare cardiac CT with lung perfusion scintigraphy for estimated pulmonary vascular volume ratio in patients with congenital heart disease. MATERIALS AND METHODS: We included 52 children and young adults (median age 4 years, range 2 months to 28 years; 31 males) with congenital heart disease who underwent cardiac CT and lung perfusion scintigraphy without an interim surgical or transcatheter intervention and within 1 year...
June 23, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28645592/enlarged-encephalo-duro-myo-synangiosis-treatment-for-moyamoya-disease-in-young-children
#2
Wenjun Shen, Bin Xu, Hao Li, Xiaofeng Gao, Yujun Liao, Wei Shi, Rui Zhao, Yi Zhang
OBJECTIVE: To retrospectively evaluate the mid-term therapeutic effect of enlarged encephalo-duro-myo-synangiosis (EDMS) for moyamoya disease (MMD) in young children. METHODS: Seventy-seven children diagnosed with MMD by digital subtraction angiography (DSA) or magnetic resonance angiography (MRA) were treated between January 2011 and December 2014 in our center. Their clinical features, imaging and operative reports were analyzed. RESULTS: Four patients presented with intracerebral hemorrhage while 73 presented with ischemic symptoms...
June 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28640793/intraoperative-computed-tomography-ct-for-treating-giant-carotid-intracavernous-aneurysms
#3
Zhe Xue, Fuyu Wang, Zhenghui Sun, Hui Zhang, Chen Wu, Dongsheng Kong, Bainan Xu
BACKGROUND Giant carotid intracavernous aneurysm refers to those lesions larger than 2.5 cm and derived from a cavernous segment, accounting for about 30% of all intracranial tumors. Dynamic CT perfusion imaging (PCT) is a common method recently employed to evaluate cerebral perfusion. This study investigated the efficacy and clinical application of intraoperative CT in the surgery for giant symptomatic carotid intracavernous aneurysm. MATERIAL AND METHODS A retrospective analysis was performed on 23 cases with giant symptomatic carotid intracavernous aneurysm...
June 22, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28638829/mitochondrial-targeted-molecular-imaging-in-cardiac-disease
#4
REVIEW
Jinhui Li, Jing Lu, You Zhou
The present study aimed to discuss the role of mitochondrion in cardiac function and disease. The mitochondrion plays a fundamental role in cellular processes ranging from metabolism to apoptosis. The mitochondrial-targeted molecular imaging could potentially illustrate changes in global and regional cardiac dysfunction. The collective changes that occur in mitochondrial-targeted molecular imaging probes have been widely explored and developed. As probes currently used in the preclinical setting still have a lot of shortcomings, the development of myocardial metabolic activity, viability, perfusion, and blood flow molecular imaging probes holds great potential for accurately evaluating the myocardial viability and functional reserve...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28638702/cerebral-blood-flow-evaluation-of-intensive-rosuvastatin-therapy-in-stroke-transient-ischemic-attack-patients-with-intracranial-arterial-atherosclerotic-stenosis-study-rationale%C3%A2-and-design
#5
Xuting Zhang, Ying Zhou, Sheng Zhang, Wenhong Ding, Min Lou
INTRODUCTION: The risk of recurrent stroke is high in patients with intracranial atherosclerotic stenosis (ICAS). Statin use has been demonstrated to decrease the incidence of stroke by reducing atherosclerotic plaque burden. However, its effect on the hemodynamic situation and cerebral perfusion status has not yet been validated. With the use of computed tomography perfusion (CTP), we aim to evaluate the impact of Rosuvastatin on cerebral hemodynamic changes, as well as the downstream perfusion...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28637776/targeting-of-extracellular-rna-reduces-edema-formation-and-infarct-size-and-improves-survival-after-myocardial-infarction-in-mice
#6
Philipp Stieger, Jan-Marcus Daniel, Christiane Thölen, Jochen Dutzmann, Kai Knöpp, Dursun Gündüz, Muhammad Aslam, Marian Kampschulte, Alexander Langheinrich, Silvia Fischer, Hector Cabrera-Fuentes, Yong Wang, Kai C Wollert, Johann Bauersachs, Rüdiger Braun-Dullaeus, Klaus T Preissner, Daniel G Sedding
BACKGROUND: Following myocardial infarction (MI), peri-infarct myocardial edema formation further impairs cardiac function. Extracellular RNA (eRNA) released from injured cells strongly increases vascular permeability. This study aimed to assess the role of eRNA in MI-induced cardiac edema formation, infarct size, cardiac function, and survival after acute MI and to evaluate the therapeutic potential of ribonuclease 1 (RNase-1) treatment as an eRNA-degrading intervention. METHODS AND RESULTS: C57BL/6J mice were subjected to MI by permanent ligation of the left anterior descending coronary artery...
June 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28636734/is-computed-tomography-perfusion-a-useful-method-for-distinguishing-between-benign-and-malignant-neck-masses
#7
Fatih Düzgün, Serdar Tarhan, Gülgün Yılmaz Ovalı, Görkem Eskiizmir, Yüksel Pabuşçu
Evaluation of neck masses is frequent in ear, nose, and throat clinics. Successful outcomes associated with neck mass are directly related to rapid diagnosis and accurate treatment for each patient. Late diagnosis of a malignant mass increases the magnitude of morbidity and the rate of mortality of the disease. Although magnetic resonance imaging and computed tomography (CT) examinations are important tools for evaluating head and neck pathologies, they do not allow functional evaluation. For this reason, CT perfusion (CTP) as a method of functional evaluation for distinguishing benign from malignant masses is gaining attention...
June 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28631142/parametric-imaging-of-11-c-flumazenil-binding-in-the-rat-brain
#8
Isadora Lopes Alves, David Vállez Vállez García, Andrea Parente, Janine Doorduin, Ana Maria Marques da Silva, Michel Koole, Rudi Dierckx, Antoon Willemsen, Ronald Boellaard
PURPOSE: This study evaluates the performance of several parametric methods for assessing [(11)C]flumazenil binding distribution in the rat brain. PROCEDURES: Dynamic (60 min) positron emission tomography data with metabolite-corrected plasma input function were retrospectively analyzed (male Wistar rats, n = 10). Distribution volume (V T) images were generated from basis function method (BFM), Logan graphical analysis (Logan), and spectral analysis (SA). Using the pons as pseudo-reference tissue, binding potential (BP ND and DVR-1) images were obtained from receptor parametric imaging algorithms (RPM and SRTM2) and reference Logan (RLogan)...
June 19, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28629564/computed-tomography-perfusion-imaging-for-monitoring-transarterial-chemoembolization-of-hepatocellular-carcinoma
#9
Herman P Marquez, Amar Karalli, Holger Haubenreisser, Rishi P Mathew, Hatem Alkadhi, Torkel B Brismar, Thomas Henzler, Michael A Fischer
PURPOSE: To prospectively monitor changes in tumor perfusion of hepatocellular carcinoma (HCC) in response to doxorubicin-eluted bead based transarterial chemoembolization (DEB-TACE) using perfusion-CT (P-CT). METHODS AND MATERIALS: 24 patients (54-79 years) undergoing P-CT before and shortly after DEB-TACE of HCC were prospectively included in this dual-center study. Two readers determined arterial-liver-perfusion (ALP, mL/min/100mL), portal-venous-perfusion (PLP, mL/min/100mL) and the hepatic-perfusion-index (HPI, %) by placing matched regions-of-interests within each HCC before and after DEB-TACE...
June 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28624924/evaluation-of-hepatic-fibrosis-a-review-from-the-society-of-abdominal-radiology-disease-focus-panel
#10
REVIEW
Jeanne M Horowitz, Sudhakar K Venkatesh, Richard L Ehman, Kartik Jhaveri, Patrick Kamath, Michael A Ohliger, Anthony E Samir, Alvin C Silva, Bachir Taouli, Michael S Torbenson, Michael L Wells, Benjamin Yeh, Frank H Miller
Hepatic fibrosis is potentially reversible; however early diagnosis is necessary for treatment in order to halt progression to cirrhosis and development of complications including portal hypertension and hepatocellular carcinoma. Morphologic signs of cirrhosis on ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) alone are unreliable and are seen with more advanced disease. Newer imaging techniques to diagnose liver fibrosis are reliable and accurate, and include magnetic resonance elastography and US elastography (one-dimensional transient elastography and point shear wave elastography or acoustic radiation force impulse imaging)...
June 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28622946/estimation-of-myocardial-flow-reserve-utilizing-an-ultrafast-cardiac-spect-comparison-with-coronary-angiography-fractional-flow-reserve-and-the-syntax-score
#11
Masao Miyagawa, Yoshiko Nishiyama, Teruyoshi Uetani, Akiyoshi Ogimoto, Shuntaro Ikeda, Hayato Ishimura, Emiri Watanabe, Rami Tashiro, Yuki Tanabe, Teruhito Kido, Akira Kurata, Teruhito Mochizuki
BACKGROUND: Quantitative assessment of myocardial flow reserve (MFR) by single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is challenging but may facilitate evaluation of multi-vessel coronary artery disease (CAD). METHODS: We enrolled 153 patients with suspected or known CAD, referred for pharmacological stress MPI. They underwent a (99m)Tc-perfusion stress/rest SPECT with an ultrafast cadmium-zinc-telluride (CZT) camera. Dynamic data were acquired and time-activity curves fitted to a 1-tissue compartment analysis with input function...
June 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28622166/quantitative-analysis-of-iodine-image-of-dual-energy-computed-tomography-at-rest-comparison-with-99mtc-tetrofosmin-stress-rest-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-as-the-reference-standard
#12
Takehiro Nakahara, Takuji Toyama, Masahiro Jinzaki, Ryotaro Seki, Yuichiro Saito, Tetsuya Higuchi, Minoru Yamada, Masashi Arai, Yoshito Tsushima, Sachio Kuribayashi, Masahiko Kurabayashi
PURPOSE: Dual-energy computed tomography (DECT) can be used for visual determination of iodine distribution in the myocardium (iodine image); however, the accuracy and reproducibility of the process remains debatable. Because of the low contrast-to-noise ratio of CT, we hypothesized that quantitative measurement may be more accurate for detecting myocardial ischemia. In this study, we evaluated our quantitative method by comparing it with visual analysis using Tc-tetrofosmin (TF) stress-rest single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) as the reference standard...
June 15, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28621587/treatment-of-severe-hypertension-in-a-14-year-old-child-successful-blood-pressure-control-with-additive-administration-of-captopril-an-angiotensin-converting-enzyme-inhibitor-in-a-patient-with-bilateral-renovascular-hypertension
#13
Xin Zhang, Ying Xu, Xiaoping Chen, Si Wang, Xinran Li, Xin Yan
We report a 14-year-old boy with recurrent episodes of headache caused by uncontrolled hypertension. The diagnosis of renovascular hypertension due to Takaysu arteritis (TA) was made based on an increase in erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) and computed tomography (CT) image of bilateral renal artery stenosis was taken. Renal scintigraphy revealed normal perfusion and function of the right kidney and severe reduction of the perfusion and function of the left kidney. Careful drug adjustments significantly improved but did not fully control the blood pressure (BP); further, angioplasty, which showed almost occlusion of the left renal artery opening and the minor narrowing of the right renal artery, failed to regain sufficient BP control...
June 16, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28621042/clinical-evaluation-of-anomalous-aortic-origin-of-a-coronary-artery-aaoca
#14
Silvana Molossi, Hitesh Agrawal
The clinical evaluation of patients with an anomalous aortic origin of a coronary artery (AAOCA), a congenital abnormality of the origin or course of a coronary artery that arises from the aorta, is challenging given its first presentation being sudden cardiac arrest in about half of the patients. Symptoms of chest pain, shortness of breath and syncope during exertion should be of concern in evaluating young athletes and nonathletes. The lack of abnormal signs on the physical exam and electrocardiogram further adds to the difficulty in establishing the diagnosis...
June 16, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28616562/coronary-calcification-compromises-myocardial-perfusion-irrespective-of-luminal-stenosis
#15
Michael Y Henein, Tarek Bengrid, Rachel Nicoll, Ying Zhao, Bengt Johansson, Axel Schmermund
AIM: The aim of this study was to evaluate the relationship between coronary artery calcification (CAC) assessed by multi-detector computed tomography (MDCT) and myocardial perfusion assessed by cardiac magnetic resonance imaging (CMR) in a group of symptomatic patients. METHOD: Retrospective analysis of 120 patients (age 65.1 ± 8.9 years, 88 males) who presented with atypical chest pain to Bethanien Hospital, Frankfurt, Germany, between 2007 and 2010 and who underwent CAC scoring using MDCT, CMR, and conventional coronary angiography...
March 2017: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28611231/validation-of-the-left-ventricular-ejection-fraction-with-iq-spect-system-in-small-heart-patients
#16
Hiroto Yoneyama, Takayuki Shibutani, Takahiro Konishi, Asuka Mizutani, Hashimoto Ryosuke, Masahisa Onoguchi, Koichi Okuda, Shinro Matsuo, Kenichi Nakajima, Kinuya Seigo
The IQ-SPECT system equipped with a multifocal (SMARTZOOM) collimator using an ordered subset conjugate gradient minimization (OSCGM) algorithm reduces the acquisition time of myocardial perfusion imaging (MPI) compared to conventional gamma cameras equipped with low-energy high-resolution (LEHR) collimators. We compared IQ-SPECT with a conventional single-photon emission computed tomography (SPECT) system for estimating the left ventricular ejection fraction (LVEF) in small-heart patients. Methods: The study group consisted of 98 consecutive patients who underwent a 1-day stress-rest MPI study with a (99m)Tc-labeled agent for preoperative risk assessment...
June 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28607546/histologic-sequelae-of-apical-hypertrophic-cardiomyopathy-dystrophic-calcification
#17
Shahryar G Saba, John N Makaryus, Navid Rahmani, Ram Jadonath
We present cardiac computed tomography (CT) findings demonstrating apical hypertrophic cardiomyopathy with dystrophic calcification of the left ventricular apex. The absence of significant epicardial coronary artery disease demonstrated by coronary CT angiography suggests that increased wall tension and decreased microvascular perfusion over time account for the dyskinetic apical myocardium, rather than myocardial infarction secondary to atherosclerotic plaque rupture. These observations support CT as the imaging modality of choice to visualize the deposition of calcium in injured myocardial tissue, a recognized occurrence in chronically infarcted myocardium...
2017: Clinical Medicine Insights. Cardiology
https://www.readbyqxmd.com/read/28605479/collapsed-stent-graft-and-severe-malperfusion-2%C3%A2-years-after-endovascular-aortic-repair
#18
Yoshihiro Goto, Soh Hosoba, Shinji Ogawa, Yoshihisa Kinoshita
Late collapsing of a stent graft is an extremely rare event, with one existing report describing this phenomenon. A 65-year-old man with a history of endovascular aortic repair for an abdominal aortic aneurysm presented with paraplegia and bilateral lower limb ischaemia. Contrast-enhanced computed tomography showed a dissection of the descending thoracic aorta and a collapsed stent graft, resulting in bilateral lower limb ischaemia. Subsequent axillo-bifemoral bypass resolved his lower extremity functions. The patient required haemodialysis due to acute kidney failure...
June 10, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28604623/dynamic-contrast-enhanced-ultrasound-of-colorectal-liver-metastases-as-an-imaging-modality-for-early-response-prediction-to-chemotherapy
#19
Marie Benzon Mogensen, Martin Lundsgaard Hansen, Birthe Merete Henriksen, Thomas Axelsen, Ben Vainer, Kell Osterlind, Michael Bachmann Nielsen
Our aim was to investigate whether dynamic contrast-enhanced ultrasound (DCE-US) can detect early changes in perfusion of colorectal liver metastases after initiation of chemotherapy. Newly diagnosed patients with colorectal cancer with liver metastases were enrolled in this explorative prospective study. Patients were treated with capecitabine or 5-fluorouracil-based chemotherapy with or without bevacizumab. DCE-US was performed before therapy (baseline) and again 10 days after initiation of treatment. Change in contrast-enhancement in one liver metastasis (indicator lesion) was measured...
June 12, 2017: Diagnostics
https://www.readbyqxmd.com/read/28604190/the-use-of-a-stent-retriever-to-cause-mechanical-dilatation-of-a-vasospasm-secondary-to-iatrogenic-subarachnoid-haemorrhage
#20
Pervinder Bhogal, Dimitris Paraskevopoulos, Hegoda Ld Makalanda
Objective To report the use of a stent-retriever in the management of vasospasm secondary to craniopharyngioma resection. Postoperative improvement was seen both clinically and on perfusion imaging. Methods A patient was admitted for resection of a large craniopharygioma. On day 6 postoperatively the patient had an acute hemiparesis. A computed tomography angiogram and perfusion scan demonstrated acute right-sided cerebral vasospasm and a perfusion defect in the territory of the middle cerebral artery (MCA)...
June 2017: Interventional Neuroradiology
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