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positron emission tomography perfusion

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https://www.readbyqxmd.com/read/30430715/recovery-of-myocardial-perfusion-after-percutaneous-coronary-intervention-of-chronic-total-occlusions-is-comparable-to-hemodynamically-significant-non-occlusive-lesions
#1
Stefan P Schumacher, Roel S Driessen, Wijnand J Stuijfzand, Pieter G Raijmakers, Ibrahim Danad, Jo Dens, James C Spratt, Colm G Hanratty, Simon J Walsh, Ronald Boellaard, Albert C van Rossum, Maksymilian P Opolski, Alexander Nap, Paul Knaapen
BACKGROUND: The benefits of chronic coronary total occlusion (CTO) percutaneous coronary intervention (PCI) are being questioned. The aim of this study was to assess the effects of CTO PCI on absolute myocardial perfusion, as compared with PCI of hemodynamically significant non-CTO lesions. METHODS: Consecutive patients with a preserved left ventricular ejection fraction (≥50%) and a CTO or non-CTO lesion, in whom [15 O]H2 O positron emission tomography was performed prior and after successful PCI, were included...
November 15, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/30429881/early-prediction-of-revascularisation-by-angiomotin-targeting-positron-emission-tomography
#2
Anais Moyon, Philippe Garrigue, Laure Balasse, Samantha Fernandez, Pauline Brige, Marie Nollet, Guillaume Hache, Marcel Blot-Chabaud, Françoise Dignat-George, Benjamin Guillet
This study aimed to develop a PET imaging agent of angiomotin (AMOT) expression, a potential biomarker of functional tissue regeneration in post-ischaemic conditions. Methods: Hindlimb ischaemia was induced by ligature and resection of the right femoral artery in mice, and clinical score and limb perfusion were evaluated up to 30 days after surgery. AMOT expression was evaluated by histology and Western blot analysis. NODAGA-conjugates of AMOT ligand, sCD146, were designed, synthesised and radiolabelled with gallium-68...
2018: Theranostics
https://www.readbyqxmd.com/read/30428740/diagnostic-pitfalls-in-ovarian-androgen-secreting-leydig-cell-tumours-case-series
#3
M Fanta, D Fischerová, T Indrielle-Kelly, P Koliba, A Zdeňková, A Burgetová, J Vrbíková
Leydig cell tumours of the ovary are rare and represent a diagnostic challenge not only due to their sporadic incidence but also due to the seemingly normal imaging. We present three cases of pre- and postmenopausal women who were presented with severe clinical signs of hyperandogenism where modern imaging modalities (including computed tomography (CT), magnetic resonance imaging (MRI) and positron-emission tomography combined with computed tomography (PET-CT)) failed to identify the tumour. Two patients underwent non-expert ultrasound, CT and MRI examination with uniform conclusion that ovaries are of normal appearance...
November 14, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/30417072/utility-of-perfusion-pet-measures-to-assess-neuronal-injury-in-alzheimer-s-disease
#4
Nelly Joseph-Mathurin, Yi Su, Tyler M Blazey, Mateusz Jasielec, Andrei Vlassenko, Karl Friedrichsen, Brian A Gordon, Russ C Hornbeck, Lisa Cash, Beau M Ances, Thomas Veale, David M Cash, Adam M Brickman, Virginia Buckles, Nigel J Cairns, Carlos Cruchaga, Alison Goate, Clifford R Jack, Celeste Karch, William Klunk, Robert A Koeppe, Daniel S Marcus, Richard Mayeux, Eric McDade, James M Noble, John Ringman, Andrew J Saykin, Paul M Thompson, Chengjie Xiong, John C Morris, Randall J Bateman, Tammie L S Benzinger
Introduction: 18 F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is commonly used to estimate neuronal injury in Alzheimer's disease (AD). Here, we evaluate the utility of dynamic PET measures of perfusion using 11 C-Pittsburgh compound B (PiB) to estimate neuronal injury in comparison to FDG PET. Methods: FDG, early frames of PiB images, and relative PiB delivery rate constants (PiB-R1) were obtained from 110 participants from the Dominantly Inherited Alzheimer Network...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/30409558/global-coronary-flow-reserve-measured-during-stress-cardiac-magnetic-resonance-imaging-is-an-independent-predictor-of-adverse-cardiovascular-events
#5
Raksha Indorkar, Raymond Y Kwong, Simone Romano, Brent E White, Richard C Chia, Michael Trybula, Kaleigh Evans, Chetan Shenoy, Afshin Farzaneh-Far
OBJECTIVES: The aim of this study was to evaluate the incremental prognostic value of global coronary flow reserve (CFR) in patients with known or suspected coronary artery disease who were undergoing stress cardiac magnetic resonance (CMR) imaging. BACKGROUND: Coronary microvascular dysfunction results in impaired global CFR and is implicated in the development of both atherosclerosis and heart failure. Although noninvasive assessment of CFR with positron emission tomography provides independent prognostic information, the incremental prognostic value of CMR-derived CFR remains unclear...
October 22, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/30390243/comparison-of-diagnostic-accuracy-of-pet-derived-myocardial-blood-flow-parameters-a-meta-analysis
#6
Sang-Geon Cho, Soo Jin Lee, Myung Hwan Na, Yun Young Choi, Henry Hee-Seung Bom
BACKGROUND: Although absolute quantification of myocardial blood flow (MBF) by positron emission tomography provides additive diagnostic value to visual analysis of perfusion defect, diagnostic accuracy of different MBF parameters remain unclear. METHODS: Clinical studies regarding the diagnostic accuracy of hyperemic MBF (hMBF), myocardial flow reserve (MFR) and/or relative flow reserve (RFR) were searched and systematically reviewed. On a per-vessel basis, pooled measures of the parameters' diagnostic performances were analyzed, regarding significant coronary stenosis defined by fractional flow reserve or diameter stenosis...
November 2, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/30388202/hybrid-coronary-computed-tomography-angiography-and-positron-emission-tomography-myocardial-perfusion-imaging-in-evaluation-of-recurrent-symptoms-after-coronary-artery-bypass-grafting
#7
Teemu Maaniitty, Samuli Jaakkola, Antti Saraste, Juhani Knuuti
Aims: Recurrent chest pain after coronary artery bypass grafting (CABG) poses a diagnostic challenge. We hypothesized that combining anatomy of bypass grafts and native coronary arteries with ischaemia detection by hybrid imaging could be used to gain valuable and complementary information in patients with recurrent symptoms after CABG. Methods and results: We analysed 36 consecutive patients (67 ± 9 years, 81% male) who had undergone hybrid imaging using coronary computed tomography angiography (CCTA) and [15O]H2O positron emission tomography (PET) myocardial perfusion imaging due to recurrent symptoms after CABG...
November 2, 2018: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/30386493/incidental-congenital-coronary-artery-vascular-fistulas-in-adults-evaluation-with-adenosine-13-n-ammonia-pet-ct
#8
Salah Am Said, Aly Agool, Arno Hm Moons, Mounir Wz Basalus, Nils Rl Wagenaar, Rogier Lg Nijhuis, Jutta M Schroeder-Tanka, Riemer Hja Slart
AIM: To assess the functionality of congenital coronary artery fistulas (CAFs) using adenosine stress 13 N-ammonia positron emission tomography computed tomography (PET-CT). METHODS: Congenital CAFs were incidentally detected during coronary angiography (CAG) procedures in 11 adult patients (six males and five females) with a mean age of 64.3 years (range 41-81). Patients were collected from three institutes in the Netherlands. The characteristics of the fistulas (origin, pathway and termination), multiplicity of the origins and pathways of the fistulous vessels were assessed by CAG...
October 26, 2018: World Journal of Cardiology
https://www.readbyqxmd.com/read/30367380/comparison-of-two-dipyridamole-infusion-protocols-for-myocardial-perfusion-imaging-in-subjects-with-low-likelihood-of-significant-obstructive-coronary-artery-disease
#9
Francois Harel, Vincent Finnerty, Sébastien Authier, Matthieu Pelletier-Galarneau
BACKGROUND: Myocardial perfusion imaging (MPI) with positron emission tomography allows accurate measurements of myocardial blood flow (MBF). Stress MBF thresholds have been proposed to provide diagnostic and prognostic information in different pathology. Most studies relying on dipyridamole use a 5-minute infusion protocol, while current guidelines recommend a 4-minute infusion. The purpose of this study is to compare the effects of different dipyridamole infusion times on stress MBF...
October 26, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/30344278/positron-emission-tomography-in-the-diagnosis-and-management-of-coronary-artery-disease
#10
REVIEW
Eglė Kazakauskaitė, Diana Žaliaduonytė-Pekšienė, Eglė Rumbinaitė, Justas Keršulis, Ilona Kulakienė, Renaldas Jurkevičius
Cardiac positron emission tomography (PET) and positron emission tomography/computed tomography (PET/CT) are encouraging precise non-invasive imaging modalities that allow imaging of the cellular function of the heart, while other non-invasive cardiovascular imaging modalities are considered to be techniques for imaging the anatomy, morphology, structure, function and tissue characteristics. The role of cardiac PET has been growing rapidly and providing high diagnostic accuracy of coronary artery disease (CAD)...
July 11, 2018: Medicina
https://www.readbyqxmd.com/read/30343093/serial-assessment-of-coronary-flow-reserve-by-rubidium-82-positron-emission-tomography-predicts-mortality-in-heart-transplant-recipients
#11
Attila Feher, Ajay Srivastava, Michael A Quail, Nabil E Boutagy, Pravien Khanna, Lynn Wilson, Edward J Miller, Yi-Hwa Liu, Forrester Lee, Albert J Sinusas
OBJECTIVES: This study aimed to evaluate the long-term prognostic value of serial assessment of coronary flow reserve (CFR) by rubidium Rb 82 (82 Rb) positron emission tomography (PET) in heart transplantation (HT) patients. BACKGROUND: Cardiac allograft vasculopathy is a major determinant of late mortality in HT recipients. The long-term prognostic value of serial CFR quantification by PET imaging in HT patients is unknown. METHODS: A total of 89 patients with history of HT (71% men, 7...
October 12, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/30334228/moving-into-the-next-era-of-pet-myocardial-perfusion-imaging-introduction-of-novel-18-f-labeled-tracers
#12
REVIEW
Rudolf A Werner, Xinyu Chen, Steven P Rowe, Constantin Lapa, Mehrbod S Javadi, Takahiro Higuchi
The heart failure epidemic continues to rise with coronary artery disease as one of its main causes. Novel concepts for risk stratification to guide the referring cardiologist towards revascularization procedures are of significant value. Myocardial perfusion imaging using single-photon emission computed tomography (SPECT) agents has demonstrated high accuracy for the detection of clinically relevant stenoses. With positron emission tomography (PET) becoming more widely available, mainly due to its diagnostic performance in oncology, perfusion imaging with that modality is more practical than in the past and overcomes existing limitations of SPECT MPI...
October 17, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/30321144/-promising-methods-of-studying-perfusion-in-patients-with-atherosclerosis-of-peripheral-arteries
#13
R E Kalinin, I A Suchkov, N D Mzhavanadze, É A Klimentova, A F Ncheĭe
Prevalence of atherosclerotic peripheral artery disease (PAD) has steadily been increasing all over the world, affecting approximately 10% of the population. PAD dramatically decreases the patients' quality of life and is accompanied by high risks of limb amputation and death. Reconstructive and restorative interventions make it possible to achieve the highest success in treatment of PAD. Their results largely depend on the state of the patient's peripheral bed. Currently, the periphery is objectively assessed by means of ultrasonographic duplex examination, digital subtraction angiography, roentgen computed tomographic angiography (CTA), and in a series of cases magnetic resonance tomographic angiography (MRA)...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/30298372/rubidium-82-positron-emission-tomography-for-detection-of-acute-doxorubicin-induced-cardiac-effects-in-lymphoma-patients
#14
Adam Høgsbro Laursen, Marie Bayer Elming, Rasmus Sejersten Ripa, Philip Hasbak, Andreas Kjær, Lars Køber, Jacob Louis Marott, Jens Jakob Thune, Martin Hutchings
BACKGROUND: Doxorubicin is a cornerstone in lymphoma treatment, but is limited by dose-dependent cardiotoxicity. Rubidium-82 positron emission tomography (82 Rb PET) assesses coronary microvascular function through absolute quantification of myocardial perfusion and myocardial perfusion reserve (MPR). Doxorubicin-induced microvascular injury represents a potential early marker of cardiotoxicity. METHODS AND RESULTS: We included 70 lymphoma patients scheduled for doxorubicin-based treatment...
October 8, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/30294409/new-trends-in-quantitative-nuclear-cardiology-methods
#15
Javier Gomez, Rami Doukky, Guido Germano, Piotr Slomka
Purpose of review: The use of quantitative analysis in single photon emission computed tomography (SPECT) and positron emission tomography (PET) has become an integral part of current clinical practice and plays a crucial role in the detection and risk stratification of coronary artery disease. Emerging technologies, new protocols, and new quantification methods have had a significant impact on the diagnostic performance and prognostic value of nuclear cardiology imaging, while reducing the need for clinician oversight...
January 2018: Current Cardiovascular Imaging Reports
https://www.readbyqxmd.com/read/30292276/crossed-cerebellar-diaschisis-in-post-treatment-glioma-patients-a-comparative-study-of-arterial-spin-labelling-and-dynamic-susceptibility-contrast
#16
Tianye Lin, Yuelei Lyu, Jianxun Qu, Xin Cheng, Xiaoyuan Fan, Yiwei Zhang, Bo Hou, Hui You, Wenbin Ma, Feng Feng
OBJECTIVES: To assess crossed cerebellar diaschisis (CCD) in post-treatment glioma patients, and to compare the performance of arterial spin labelling (ASL) and dynamic susceptibility contrast (DSC) in detecting CCD. METHODS AND MATERIALS: This retrospective study included 130 patients who had both DSC and ASL. Among them, 16 had underwent fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG PET/CT). We investigated the relationship between CCD and the location and size of supratentorial lesions, and compared PET diagnostic performance with that of ASL and DSC...
October 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/30284241/a-pilot-study-of-cardiopulmonary-exercise-testing-and-cardiac-stress-positron-emission-tomography-before-major-non-cardiac-surgery
#17
M T Ferguson, M S Hofman, H Ismail, A Melville, K S K Yap, R J Hicks, S Wright, B Riedel
Cardiac events are a common cause of peri-operative morbidity. Cardiopulmonary exercise testing can objectively assess risk, but it does not quantify myocardial ischaemia. With appropriate dietary preparation to suppress basal myocardial glucose uptake, positron emission tomography with 18 F-fluorodeoxyglucose can identify post-ischaemic myocardium, providing an attractive complement to exercise testing. We aimed to investigate the feasibility of this diagnostic algorithm. Patients referred for cardiopulmonary exercise testing before major cancer surgery were prospectively recruited...
October 3, 2018: Anaesthesia
https://www.readbyqxmd.com/read/30281918/assessment-of-tumour-response-after-stereotactic-ablative-radiation-therapy-for-lung-cancer-a-prospective-quantitative-hybrid-18-f-fluorodeoxyglucose-positron-emission-tomography-and-ct-perfusion-study
#18
Dae-Myoung Yang, David Palma, Alexander Louie, Richard Malthaner, Dalilah Fortin, George Rodrigues, Brian Yaremko, Joanna Laba, Stewart Gaede, Andrew Warner, Richard Inculet, Ting-Yim Lee
INTRODUCTION: Stereotactic ablative radiotherapy (SABR) is a guideline-recommended treatment for inoperable stage I non-small cell lung cancer (NSCLC), but imaging assessment of response after SABR is difficult. The goal of this study was to evaluate imaging-based biomarkers of tumour response using dynamic 18 F-FDG-PET and CT perfusion (CTP). METHODS: Thirty-one patients with early-stage NSCLC participated in this prospective correlative study. Each underwent dynamic 18 F-FDG-PET/CTP studies on a PET/CT scanner pre- and 8 weeks post-SABR...
October 3, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/30268877/doppler-flow-velocity-and-thermodilution-to-assess-coronary-flow-reserve-a-head-to-head-comparison-with-15-o-h-2-o-pet
#19
Henk Everaars, Guus A de Waard, Roel S Driessen, Ibrahim Danad, Peter M van de Ven, Pieter G Raijmakers, Adriaan A Lammertsma, Albert C van Rossum, Paul Knaapen, Niels van Royen
OBJECTIVES: This study sought to compare Doppler flow velocity reserve (CFRDoppl ) and thermodilution-derived coronary flow reserve (CFRthermo ) head-to-head with the gold standard for quantification of myocardial perfusion, [15 O]H2 O positron emission tomography (PET). BACKGROUND: Coronary flow reserve (CFR) is an important parameter for assessing coronary vascular function. To date, 2 techniques are available for invasive assessment of CFR: Doppler flow velocity and thermodilution...
October 22, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/30267168/myocardial-bridging-of-the-left-anterior-descending-coronary-artery-is-associated-with-reduced-myocardial-perfusion-reserve-a-13-n-ammonia-pet-study
#20
Andrea G Monroy-Gonzalez, Erick Alexanderson-Rosas, Niek H J Prakken, Luis E Juarez-Orozco, Lourdes Walls-Laguarda, Enrique A Berrios-Barcenas, Aloha Meave-Gonzalez, Jan C Groot, Riemer H J A Slart, Rene A Tio
Myocardial Bridging (MB) refers to the band of myocardium that abnormally overlies a segment of a coronary artery. This paper quantitatively evaluates the influence of MB of the left anterior descending artery (LAD) on myocardial perfusion of the entire left ventricle. We studied 131 consecutive patients who underwent hybrid rest/stress 13 N-ammonia positron emission tomography (PET) and coronary computed tomography angiography (CCTA) due to suspected myocardial ischemia. Patients with previous myocardial infarction and/or significant coronary artery disease (≥ 50% stenosis) were excluded...
September 28, 2018: International Journal of Cardiovascular Imaging
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