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positron emission tomography perfusion

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https://www.readbyqxmd.com/read/28213449/optimal-adenosine-stress-for-maximum-stress-perfusion-coronary-flow-reserve-and-pixel-distribution-of-coronary-flow-capacity-by-kolmogorov-smirnov-analysis
#1
Danai Kitkungvan, Dejian Lai, Hongjian Zhu, Amanda E Roby, Nils P Johnson, Derek D Steptoe, Monica B Patel, Richard Kirkeeide, K Lance Gould
BACKGROUND: Different adenosine stress imaging protocols have not been systemically validated for absolute myocardial perfusion and coronary flow reserve (CFR) by positron emission tomography, where submaximal stress precludes assessing physiological severity of coronary artery disease. METHODS AND RESULTS: In 127 volunteers, serial rest-stress positron emission tomography scans using rubidium-82 with various adenosine infusion protocols identified (1) the protocol with maximum stress perfusion and CFR, (2) test-retest precision in same subject, (3) stress perfusion and CFR after adenosine compared with dipyridamole, (4) heterogeneity of coronary flow capacity combining stress perfusion and CFR, and (5) potential relevance for patients with risk factors or coronary artery disease...
February 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28213330/drug-discovery-strategies-in-the-field-of-tumor-energy-metabolism-limitations-by-metabolic-flexibility-and-metabolic-resistance-to-chemotherapy
#2
REVIEW
N D Amoedo, E Obre, R Rossignol
The search for new drugs capable of blocking the metabolic vulnerabilities of human tumors has now entered the clinical evaluation stage, but several projects already failed in phase I or phase II. In particular, very promising in vitro studies could not be translated in vivo at preclinical stage and beyond. This was the case for most glycolysis inhibitors that demonstrated systemic toxicity. A more recent example is the inhibition of glutamine catabolism in lung adenocarcinoma that failed in vivo despite a strong addiction of several cancer cell lines to glutamine in vitro...
February 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28208155/pet-mr-in-invasive-ductal-breast-cancer-correlation-between-imaging-markers-and-histological-phenotype
#3
Onofrio Antonio Catalano, Gary Lloyd Horn, Alberto Signore, Carlo Iannace, Maria Lepore, Mark Vangel, Angelo Luongo, Marco Catalano, Constance Lehman, Marco Salvatore, Andrea Soricelli, Ciprian Catana, Umar Mahmood, Bruce Robert Rosen
BACKGROUND: Differences in genetics and receptor expression (phenotypes) of invasive ductal breast cancer (IDC) impact on prognosis and treatment response. Immunohistochemistry (IHC), the most used technique for IDC phenotyping, has some limitations including its invasiveness. We explored the possibility of contrast-enhanced positron emission tomography magnetic resonance (CE-FDG PET/MR) to discriminate IDC phenotypes. METHODS: 21 IDC patients with IHC assessment of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor-2 (HER2), and antigen Ki-67 (Ki67) underwent CE-FDG PET/MR...
February 16, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28207200/a-pet-guided-framework-supports-a-multiple-arterial-input-functions-approach-in-dsc-mri-in-acute-stroke
#4
Michelle Livne, Vince I Madai, Peter Brunecker, Olivier Zaro-Weber, Walter Moeller-Hartmann, Wolf-Dieter Heiss, Kim Mouridsen, Jan Sobesky
BACKGROUND AND PURPOSE: In acute stroke, arterial-input-function (AIF) determination is essential for obtaining perfusion estimates with dynamic susceptibility-weighted contrast-enhanced magnetic resonance imaging (DSC-MRI). Standard DSC-MRI postprocessing applies single AIF selection, ie, global AIF. Physiological considerations, however, suggest that a multiple AIFs selection method would improve perfusion estimates to detect penumbral flow. In this study, we developed a framework based on comparable DSC-MRI and positron emission tomography (PET) images to compare the two AIF selection approaches and assess their performance in penumbral flow detection in acute stroke...
February 16, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28202051/variability-of-radiation-doses-of-cardiac-diagnostic-imaging-tests-the-radio-evinci-study-radiationdose-subproject-of-the-evinci-study
#5
Clara Carpeggiani, Eugenio Picano, Marco Brambilla, Claudio Michelassi, Juhani Knuuti, Philipp Kauffman, S Richard Underwood, Danilo Neglia
BACKGROUND: Patients with coronary artery disease can accumulate significant radiation dose through repeated exposures to coronary computed tomographic angiography, myocardial perfusion imaging with single photon emission computed tomography or positron emission tomography, and to invasive coronary angiography. Aim of the study was to audit radiation doses of coronary computed tomographic angiography, single photon emission computed tomography, positron emission tomography and invasive coronary angiography in patients enrolled in the prospective, randomized, multi-centre European study-EVINCI (Evaluation of Integrated Cardiac Imaging for the Detection and Characterization of Ischemic Heart Disease)...
February 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28188475/myocardial-perfusion-imaging-with-pet
#6
Roel S Driessen, Pieter G Raijmakers, Wijnand J Stuijfzand, Paul Knaapen
Noninvasive assessment of coronary artery disease remains a challenging task, with a large armamentarium of diagnostic modalities. Myocardial perfusion imaging (MPI) is widely used for this purpose whereby cardiac positron emission tomography (PET) is considered the gold standard. Next to relative radiotracer distribution, PET allows for measurement of absolute myocardial blood flow. This quantification of perfusion improves diagnostic accuracy and prognostic value. Cardiac hybrid imaging relies on the fusion of anatomical and functional imaging using coronary computed tomography angiography and MPI, respectively, and provides incremental value as compared with either stand-alone modality...
February 10, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28183993/multiparametric-imaging-of-tumor-hypoxia-and-perfusion-with-18-f-fmiso-dynamic-pet-in-head-and-neck-cancer
#7
Milan Grkovski, Heiko Schöder, Nancy Lee, Sean D Carlin, Bradley Jay Beattie, Nadeem Riaz, Jonathan E Leeman, Joseph A O'Donoghue, John Laurence Humm
Tumor hypoxia and perfusion are independent prognostic indicators of patient outcome. We developed the methodology for, and investigated the utility of multiparametric imaging of tumor hypoxia and perfusion with (18)F-fluoromisonidazole (FMISO) dynamic positron emission tomography (dPET) in head and neck cancer (HNC). Methods: 120 HNC patients underwent 0-30 min FMISO dPET in a customized immobilization mask, followed by 10 min static acquisitions starting at 93±6 and 160±13 min post-injection. A total of 248 lesions (≥2 cm(3)) were analyzed...
February 9, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28150111/spect-and-pet-in-ischemic-heart-failure
#8
George Angelidis, Gregory Giamouzis, Georgios Karagiannis, Javed Butler, Ioannis Tsougos, Varvara Valotassiou, George Giannakoulas, Nikolaos Dimakopoulos, Andrew Xanthopoulos, John Skoularigis, Filippos Triposkiadis, Panagiotis Georgoulias
Heart failure is a common clinical syndrome associated with significant morbidity and mortality worldwide. Ischemic heart disease is the leading cause of heart failure, at least in the industrialized countries. Proper diagnosis of the syndrome and management of patients with heart failure require anatomical and functional information obtained through various imaging modalities. Nuclear cardiology techniques play a main role in the evaluation of heart failure. Myocardial single photon emission computed tomography (SPECT) with thallium-201 or technetium-99 m labelled tracers offer valuable data regarding ventricular function, myocardial perfusion, viability, and intraventricular synchronism...
February 2, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28149758/defining-the-endpoints-how-to-measure-the-efficacy-of-drugs-that-are-active-against-central-nervous-system-metastases
#9
REVIEW
Alessandra Fabi, Antonello Vidiri
Brain metastases (BMs) are the most common cause of malignant central nervous system (CNS) tumors in adults. In the recent past, patients with BMs were excluded from clinical trials, but now, with the advent of new biological and immunological drugs, their inclusion is more common. In the last era response and progression criteria used across clinical trials have defined the importance to consider not only measurement changes of brain lesions but also the modification of parameters related to the metastases such as metabolism of tissue and its pathological features...
December 2016: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28137454/residual-activity-correction-in-quantitative-myocardial-perfusion-13-n-ammonia-pet-imaging-a-study-in-post-mi-patients
#10
George Markousis-Mavrogenis, Luis Eduardo Juárez-Orozco, Erick Alexanderson
BACKGROUND/INTRODUCTION/AIM: Positron Emission Tomography (PET) is the gold standard for quantification of Myocardial Blood Flow (MBF). A standard PET scan is acquired in two phases (rest and pharmacological stress). (13)N-ammonia is a perfusion radiotracer that may show residual activity which may affect MBF estimation during the second phase of the scan. An algorithm for Residual Activity Correction (RAC) is available when reconstruction is performed using Syngo MBF (by Siemens). The aim of this study was to evaluate differentes in MBF estimation with and without RAC by Syngo MBF in patients with a previous MI using (13)N-ammonia PET...
January 27, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28129334/a-novel-positron-emission-tomography-pet-approach-to-monitor-cardiac-metabolic-pathway-remodeling-in-response-to-sunitinib-malate
#11
Alice C O'Farrell, Rhys Evans, Johanna M U Silvola, Ian S Miller, Emer Conroy, Suzanne Hector, Maurice Cary, David W Murray, Monika A Jarzabek, Ashwini Maratha, Marina Alamanou, Girish Mallya Udupi, Liam Shiels, Celine Pallaud, Antti Saraste, Heidi Liljenbäck, Matti Jauhiainen, Vesa Oikonen, Axel Ducret, Paul Cutler, Fionnuala M McAuliffe, Jacques A Rousseau, Roger Lecomte, Suzanne Gascon, Zoltan Arany, Bonnie Ky, Thomas Force, Juhani Knuuti, William M Gallagher, Anne Roivainen, Annette T Byrne
Sunitinib is a tyrosine kinase inhibitor approved for the treatment of multiple solid tumors. However, cardiotoxicity is of increasing concern, with a need to develop rational mechanism driven approaches for the early detection of cardiac dysfunction. We sought to interrogate changes in cardiac energy substrate usage during sunitinib treatment, hypothesising that these changes could represent a strategy for the early detection of cardiotoxicity. Balb/CJ mice or Sprague-Dawley rats were treated orally for 4 weeks with 40 or 20 mg/kg/day sunitinib...
2017: PloS One
https://www.readbyqxmd.com/read/28126891/2-18f-fluoroethanol-is-a-novel-positron-emission-tomography-pet-reporter-of-solid-tumour-perfusion
#12
Brennan J Wadsworth, Jinhe Pan, Iulia Dude, Nadine Colpo, Momir Bosiljcic, Kuo Shyan Lin, Francois Benard, Kevin L Bennewith
: Solid tumour perfusion is a proven variable of interest for predicting cancer aggression and response to therapy. Current methods for non-invasively imaging tumour perfusion with positron emission tomography (PET) are limited by restricted accessibility and short half-lives of perfusion radiotracers. This study presents 2-(18)F-fluoroethanol (2-(18)F-FEtOH) as a perfusion reporter that can distinguish between tumours of varying perfusion levels and can be applied to screening drugs that modify tumour perfusion...
January 26, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28120237/hibernating-substrate-of-ventricular-tachycardia-a-three-dimensional-metabolic-and-electro-anatomic-assessment
#13
Ayman A Hussein, Michelle Niekoop, Vasken Dilsizian, Yousra Ghzally, Mohammed Abdulghani, Ramazan Asoglu, Wengen Chen, Mark Smith, Vincent See, Stephen R Shorofsky, Timm-Michael Dickfeld
PURPOSE: Hibernating myocardium (HM) is associated with sudden cardiac death (SCD). Little is known about the electrophysiological properties of HM and the basis of its association with SCD. We aimed to electrophysiologically characterize HM in patients with ventricular tachycardia (VT). METHODS: Endocardial voltage mapping, metabolic (18)FDG-positron emission tomography (PET) and perfusion (82)Rb, (201)Tl, or (99m)Tc scans were performed in 61 ischemic heart disease patients with VT...
January 25, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28114983/panaxatriol-saponins-promotes-angiogenesis-and-enhances-cerebral-perfusion-after-ischemic-stroke-in-rats
#14
Zhen Hui, Du-Juan Sha, Su-Lei Wang, Chao-Sheng Li, Jian Qian, Jing-Qing Wang, Yang Zhao, Jing-Hua Zhang, Hong-Yu Cheng, Hui Yang, Lin-Jie Yu, Yun Xu
BACKGROUND: Panaxatriol saponins (PTS), an extract from the traditional Chinese herb Panax notoginseng, which has been used to treat ischemic stroke for many years in China. However, the mechanism underlying the effects of PTS remains unclear. This study aimed to determine whether PTS can protect against ischemic brain injury by promoting angiogenesis and to explore the possible mechanism by which it promotes angiogenesis. METHODS: Middle cerebral artery occlusion (MCAO) was induced in rats, and neurological deficit scores and brain infarct volumes were assessed...
January 23, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28113072/rapid-synthesis-of-68-ga-labeled-macroaggregated-human-serum-albumin-maa-for-routine-application-in-perfusion-imaging-using-pet-ct
#15
D Mueller, Harshad Kulkarni, Richard P Baum, Andreas Odparlik
(99m)Tc-labeled MAA is commonly used for single photon emission computed tomography SPECT. In contrast, positron emission tomography/CT (PET/CT) delivers images with significantly higher resolution. The generator produced radionuclide (68)Ga is widely used for PET/CT imaging agents and (68)Ga-labeled MAA represents an attractive alternative to (99m)Tc-labeled MAA. We report a simple and rapid NaCl based labeling procedure for the labeling of MAA with (68)Ga using a commercially available MAA labeling kit for (99m)Tc...
January 9, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28109920/myocardial-blood-flow-and-inflammatory%C3%A2-cardiac-sarcoidosis
#16
Matthew J Kruse, Lara Kovell, Edward K Kasper, Martin G Pomper, David R Moller, Lilja Solnes, Edward S Chen, Thomas H Schindler
OBJECTIVES: This study sought to evaluate the effects of inflammatory sarcoid disease on coronary circulatory function and the response to immune-suppressive treatment. BACKGROUND: Although positron emission tomography assessment of myocardial inflammation is increasingly applied to identify active cardiac sarcoidosis, its effect on coronary flow and immune-suppressive treatment remains to be characterized. METHODS: Thirty-two individuals, who were referred for positron emission tomography/computed tomography, were evaluated for known or suspected cardiac sarcoidosis applying (18)F-fluorodeoxyglucose to determine inflammation and (13)N-ammonia to assess for perfusion deficits following a high-fat/low-carbohydrate diet and fasting state >12 h to suppress myocardial glucose uptake...
February 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28091979/blood-perfusion-in-osteomyelitis-studied-with-15-o-water-pet-in-a-juvenile-porcine-model
#17
Lars Jødal, Ole L Nielsen, Pia Afzelius, Aage K O Alstrup, Søren B Hansen
BACKGROUND: Osteomyelitis is a serious disease which can be difficult to treat despite properly instituted antibiotic therapy. This appears to be related at least partly to degraded vascularisation in the osteomyelitic (OM) lesions. Studies of perfusion in OM bones are, however, few and not quantitative. Quantitative assessment of perfusion could aid in the selection of therapy. A non-invasive, quantitative way to study perfusion is dynamic [(15)O]water positron emission tomography (PET)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28035179/molecular-neuroimaging-in-posttraumatic-stress-disorder
#18
REVIEW
Jooyeon Jamie Im, Eun Namgung, Yejee Choi, Jung Yoon Kim, Sandy Jeong Rhie, Sujung Yoon
Over the past decade, an increasing number of neuroimaging studies have provided insight into the neurobiological mechanisms of posttraumatic stress disorder (PSTD). In particular, molecular neuroimaging techniques have been employed in examining metabolic and neurochemical processes in PTSD. This article reviews molecular neuroimaging studies in PTSD and focuses on findings using three imaging modalities including positron emission tomography (PET), single photon emission computed tomography (SPECT), and magnetic resonance spectroscopy (MRS)...
December 2016: Experimental Neurobiology
https://www.readbyqxmd.com/read/28029273/mri-based-mismatch-detection-in-acute-ischemic-stroke-optimal-pwi-maps-and-thresholds-validated-with-pet
#19
Olivier Zaro-Weber, Walter Moeller-Hartmann, Dora Siegmund, Alexandra Kandziora, Alexander Schuster, Wolf-Dieter Heiss, Jan Sobesky
Perfusion-weighted (PW) magnetic resonance imaging (MRI) is used to detect penumbral tissue in acute stroke, but the selection of optimal PW-maps and thresholds for tissue at risk detection remains a matter of debate. We validated the performance of PW-maps with 15O-water-positron emission tomography (PET) in a large comparative PET-MR cohort of acute stroke patients. In acute and subacute stroke patients with back-to-back MRI and PET imaging, PW-maps were validated with 15O-water-PET. We pooled two different cerebral blood flow (CBF) PET-maps to define the critical flow (CF) threshold, (i) quantitative (q)CBF-PET with the CF threshold <20 ml/100 g/min and (ii) normalized non-quantitative (nq)CBF-PET with a CF threshold of <70% (corresponding to <20 ml/100 g/min according to a previously published normogram)...
January 1, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28017383/routine-clinical-quantitative-rest-stress-myocardial-perfusion-for-managing-coronary-artery-disease-clinical-relevance-of-test-retest-variability
#20
Danai Kitkungvan, Nils P Johnson, Amanda E Roby, Monika B Patel, Richard Kirkeeide, K Lance Gould
OBJECTIVES: Positron emission tomography (PET) quantifies stress myocardial perfusion (in cc/min/g) and coronary flow reserve to guide noninvasively the management of coronary artery disease. This study determined their test-retest precision within minutes and daily biological variability essential for bounding clinical decision-making or risk stratification based on low flow ischemic thresholds or follow-up changes. BACKGROUND: Randomized trials of fractional flow reserve-guided percutaneous coronary interventions established an objective, quantitative, outcomes-driven standard of physiological stenosis severity...
December 21, 2016: JACC. Cardiovascular Imaging
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