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positron emission tomography perfusion

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https://www.readbyqxmd.com/read/27908971/13n-ammonia-pet-ct-detection-of-myocardial-perfusion-abnormalities-in-beagle-dogs-after-local-heart-irradiation
#1
Jianbo Song, Rui Yan, Zhifang Wu, Jianguo Li, Min Yan, Xinzhong Hao, Jianzhong Liu, Sijin Li
: To determine the potential value of (13)N-ammonia positron emission tomography (PET)/computed tomography (CT) myocardial perfusion imaging (MPI) for detection of myocardial perfusion changes at early stage induced by radiation damage. METHODS: Thirty-six Beagle dogs were randomly divided into the control (n = 18) or the irradiation groups (n = 18). The irradiation group underwent local irradiation to the left ventricular anterior cardiac wall with a single dose of 20 Gy, whereas the control group received sham irradiation...
December 1, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27881570/excess-cardiovascular-risk-in-women-relative-to-men-referred-for-coronary-angiography-is-associated-with-severely-impaired-coronary-flow-reserve-not-obstructive-disease
#2
Viviany R Taqueti, Leslee J Shaw, Nancy R Cook, Venkatesh L Murthy, Nishant R Shah, Courtney R Foster, Jon Hainer, Ron Blankstein, Sharmila Dorbala, Marcelo F Di Carli
BACKGROUND: -Cardiovascular disease (CVD) fatality rates are higher for women as compared with men, yet obstructive coronary artery disease (CAD) is less prevalent in women. Coronary flow reserve (CFR), an integrated measure of large and small vessel CAD and myocardial ischemia, identifies patients at risk for CVD death, but is not routinely measured in clinical practice. We sought to investigate the impact of sex, CFR, and angiographic CAD severity on adverse cardiovascular events. METHODS: -Consecutive patients (N=329, 43% women) referred for invasive coronary angiography after stress testing with myocardial perfusion positron emission tomography (PET) and with left ventricular ejection fraction >40% were followed (median 3...
November 14, 2016: Circulation
https://www.readbyqxmd.com/read/27880734/the-role-of-necrosis-acute-hypoxia-and-chronic-hypoxia-in-18-f-fmiso-pet-image-contrast-a-computational-modelling-study
#3
Daniel R Warren, Mike Partridge
Positron emission tomography (PET) using (18)F-fluoromisonidazole (FMISO) is a promising technique for imaging tumour hypoxia, and a potential target for radiotherapy dose-painting. However, the relationship between FMISO uptake and oxygen partial pressure ([Formula: see text]) is yet to be quantified fully. Tissue oxygenation varies over distances much smaller than clinical PET resolution (<100 μm versus  ∼4 mm), and cyclic variations in tumour perfusion have been observed on timescales shorter than typical FMISO PET studies (∼20 min versus a few hours)...
December 21, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27879370/validation-of-mri-determination-on-pet-measurements-in-ischemic-stroke
#4
Wolf-Dieter Heiss, Olivier Zaro Weber
The concept of the ischemic penumbra was formulated based on animal experiments showing functional impairment and electrophysiological disturbances with decreasing flow to the brain below defined values (the threshold for function) and irreversible tissue damage with blood supply further decreased (the threshold for infarction). The perfusion range between these thresholds was termed "penumbra", and restitution of flow above the functional threshold was able to reverse the deficits without permanent damage...
November 22, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27870973/transthoracic-doppler-echocardiography-compared-with-positron-emission-tomography-for-assessment-of-coronary-microvascular-dysfunction-the-ipower-study
#5
Marie Mide Michelsen, Naja Dam Mygind, Adam Pena, Rasmus Huan Olsen, Thomas Emil Christensen, Adam Ali Ghotbi, Philip Hasbak, Andreas Kjaer, Ida Gustafsson, Peter Riis Hansen, Henrik Steen Hansen, Nis Høst, Jens Kastrup, Eva Prescott
BACKGROUND: Coronary microvascular function can be assessed by transthoracic Doppler echocardiography as a coronary flow velocity reserve (TTDE CFVR) and by positron emission tomography as a myocardial blood flow reserve (PET MBFR). PET MBFR is regarded the noninvasive reference standard for measuring coronary microvascular function but has limited availability. We compared TTDE CFVR with PET MBFR in women with angina pectoris and no obstructive coronary artery disease and assessed repeatability of TTDE CFVR...
November 7, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27855349/comparison-of-rest-and-adenosine-stress-quantitative-and-semi-quantitative-myocardial-perfusion-using-magnetic-resonance-in-patients-with-ischemic-heart-disease
#6
Abbas A Qayyum, Faiza Qayyum, Henrik Bw Larsson, Andreas Kjaer, Philip Hasbak, Niels G Vejlstrup, Jens Kastrup
The aim was to compare absolute quantified myocardial perfusion (MP) to semi-quantitative measurements of MP using MRI for detection of ischemia. Twenty-nine patients underwent rest and stress MP imaging obtained by 1.5T MRI and analyzed using own developed software and by commercial available software. Linear regression analysis demonstrated that absolute quantitative data correlated stronger to maxSI (rest: r=0.296, p=.193; stress: r=0.583, p=0.011; myocardial perfusion reserve (MPR): r=0.789, p<0.001; and Δ myocardial blood flow (Δ MBF: r=0...
November 5, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27848160/coronary-flow-reserve-and-relative-flow-reserve-measured-by-n-13-ammonia-pet-for-characterization-of-coronary-artery-disease
#7
Sang-Geon Cho, Ki Seong Park, Jahae Kim, Sae-Ryung Kang, Ho-Chun Song, Ju Han Kim, Jae Yeong Cho, Young Joon Hong, Zeenat Jabin, Hee Jeong Park, Geum-Cheol Jeong, Seong Young Kwon, Jin Chul Paeng, Hyeon Sik Kim, Jung-Joon Min, Ernest V Garcia, Henry Hee-Seung Bom
OBJECTIVE: We evaluated the relationships between coronary flow reserve (CFR) and relative flow reserve (RFR) measured by N-13 ammonia positron emission tomography (PET) for characterization of epicardial coronary artery disease (CAD). METHODS: Sixty-nine consecutive stable angina patients underwent N-13 ammonia PET, coronary computed tomography angiography (CCTA), and if necessary, invasive coronary angiography (CAG) within 2 weeks. Myocardial blood flow (MBF), CFR, RFR, and coronary vascular resistance of the reference arterial territory (CVRref) were measured by N-13 ammonia PET...
November 15, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27824931/glucose-metabolism-and-its-complicated-relationship-with-tumor-growth-and-perfusion-in-head-and-neck-squamous-cell-carcinoma
#8
Noriyuki Fujima, Tomohiro Sakashita, Akihiro Homma, Kenji Hirata, Tohru Shiga, Kohsuke Kudo, Hiroki Shirato
OBJECTIVE: To determine the relationship between tumor glucose metabolism and tumor blood flow (TBF) in head and neck squamous cell carcinoma (HNSCC). METHODS: We retrospectively analyzed 57 HNSCC patients. Tumor glucose metabolism was assessed by maximum and mean standardized uptake values (SUVmax and SUVmean) obtained by 18F-fluorodeoxyglucose positron-emission tomography. TBF values were obtained by arterial spin labeling with 3-tesla MRI. The correlations between both SUVs and TBF were assessed in the total series and among patients divided by T-stage (T1-T3 and T4 groups) and tumor location (pharynx/oral cavity and sinonasal cavity groups)...
2016: PloS One
https://www.readbyqxmd.com/read/27816875/differentiation-of-recurrent-spinal-ependymoma-from-postradiation-treatment-necrosis-through-multiparametric-pet-mr-and-perfusion-mri
#9
Mojgan Hojjati, Vasant Garg, Chaitra A Badve, Salim E Abboud, Andrew E Sloan, Leo J Wolansky
A 67-year-old male presented with papilledema and back pain localized to the T10 level. Initial workup revealed multifocal spinal ependymoma which was resected and treated with external beam radiotherapy. Nine years after treatment, the patient had a relapse of back pain, and MRI was inconclusive in distinguishing posttreatment radiation necrosis from recurrent tumor. We present the first described report with the utilization of multiparametric positron emission tomography-magnetic resonance imaging and perfusion MRI to distinguish recurrent spinal ependymoma from radiation necrosis...
September 13, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27804070/effect-of-remote-ischemic-conditioning-on-myocardial-perfusion-in-patients-with-suspected-ischemic-coronary-artery-disease
#10
Kasper Pryds, Roni Ranghøj Nielsen, Camilla Molich Hoff, Lars Poulsen Tolbod, Kirsten Bouchelouche, Jing Li, Michael Rahbek Schmidt, Andrew N Redington, Jørgen Frøkiær, Hans Erik Bøtker
BACKGROUND: Remote ischemic conditioning (RIC) confers protection against myocardial ischemia-reperfusion injury and may modulate coronary blood flow. We investigated whether RIC affects resting myocardial perfusion (MP) in patients with suspected ischemic coronary artery disease by quantitative MP imaging. METHODS AND RESULTS: We included 49 patients with suspected ischemic coronary artery disease. Resting MP was quantified by (82)Rubidium positron emission tomography/computed tomography ((82)Rb-PET/CT) imaging before and after RIC, performed as four cycles of 5 minutes upper arm ischemia and reperfusion...
November 1, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27779790/voxelwise-analysis-of-simultaneously-acquired-and-spatially-correlated-18-f-fluorodeoxyglucose-fdg-pet-and-intravoxel-incoherent-motion-metrics-in-breast-cancer
#11
Jason Ostenson, Akshat C Pujara, Artem Mikheev, Linda Moy, Sungheon G Kim, Amy N Melsaether, Komal Jhaveri, Sylvia Adams, David Faul, Christopher Glielmi, Christian Geppert, Thorsten Feiweier, Kimberly Jackson, Gene Y Cho, Fernando E Boada, Eric E Sigmund
PURPOSE: Diffusion-weighted imaging (DWI) and (18) F-fluorodeoxyglucose-positron emission tomography ((18) F-FDG-PET) independently correlate with malignancy in breast cancer, but the relationship between their structural and metabolic metrics is not completely understood. This study spatially correlates diffusion, perfusion, and glucose avidity in breast cancer with simultaneous PET/MR imaging and compares correlations with clinical prognostics. METHODS: In this Health Insurance Portability and Accountability Act-compliant prospective study, with written informed consent and approval of the institutional review board and using simultaneously acquired FDG-PET and DWI, tissue diffusion (Dt ), and perfusion fraction (fp ) from intravoxel incoherent motion (IVIM) analysis were registered to FDG-PET within 14 locally advanced breast cancers...
October 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27771003/effect-of-diffuse-subendocardial-hypoperfusion-on-left-ventricular-cavity-size-by-13-n-ammonia-perfusion-pet-in-patients-with-hypertrophic-cardiomyopathy
#12
Hulya Yalçin, Ines Valenta, Fatih Yalçin, Celia Corona-Villalobos, Nestor Vasquez, Joshua Ra, Nagehan Kucukler, Abdel Tahari, Iraklis Pozios, Yun Zhou, Martin Pomper, Theodore P Abraham, Thomas H Schindler, M Roselle Abraham
Vasodilator-induced transient left ventricular (LV) cavity dilation by positron emission tomography (PET) is common in patients with hypertrophic cardiomyopathy (HC). Because most patients with PET-LV cavity dilation lack obstructive epicardial coronary artery disease, we hypothesized that vasodilator-induced subendocardial hypoperfusion resulting from microvascular dysfunction underlies this result. To test this hypothesis, we quantified myocardial blood flow (MBF) (subepicardial, subendocardial, and global MBF) and left ventricular ejection fraction (LVEF) in 104 patients with HC without significant coronary artery disease, using (13)NH3-PET...
September 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27768066/long-term-high-resolution-intravital-microscopy-in-the-lung-with-a-vacuum-stabilized-imaging-window
#13
Carolina Rodriguez-Tirado, Takanori Kitamura, Yu Kato, Jeffery W Pollard, John S Condeelis, David Entenberg
Metastasis to secondary sites such as the lung, liver and bone is a traumatic event with a mortality rate of approximately 90% (1). Of these sites, the lung is the most difficult to assess using intravital optical imaging due to its enclosed position within the body, delicate nature and vital role in sustaining proper physiology. While clinical modalities (positron emission tomography (PET), magnetic resonance imaging (MRI) and computed tomography (CT)) are capable of providing noninvasive images of this tissue, they lack the resolution necessary to visualize the earliest seeding events, with a single pixel consisting of nearly a thousand cells...
October 6, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27755938/arterial-spin-labeling-perfusion-of-the-brain-emerging-clinical-applications
#14
Sven Haller, Greg Zaharchuk, David L Thomas, Karl-Olof Lovblad, Frederik Barkhof, Xavier Golay
Arterial spin labeling (ASL) is a magnetic resonance (MR) imaging technique used to assess cerebral blood flow noninvasively by magnetically labeling inflowing blood. In this article, the main labeling techniques, notably pulsed and pseudocontinuous ASL, as well as emerging clinical applications will be reviewed. In dementia, the pattern of hypoperfusion on ASL images closely matches the established patterns of hypometabolism on fluorine 18 fluorodeoxyglucose (FDG) positron emission tomography (PET) images due to the close coupling of perfusion and metabolism in the brain...
November 2016: Radiology
https://www.readbyqxmd.com/read/27752544/hypoxia-imaging-with-pet-correlates-with-antitumor-activity-of-the-hypoxia-activated-prodrug-evofosfamide-th-302-in-rodent-glioma-models
#15
Ashley M Stokes, Charles P Hart, C Chad Quarles
High-grade gliomas are often characterized by hypoxia, which is associated with both poor long-term prognosis and therapy resistance. The adverse role hypoxia plays in treatment resistance and disease progression has led to the development of hypoxia imaging methods and hypoxia-targeted treatments. Here, we determined the tumor hypoxia and vascular perfusion characteristics of 2 rat orthotopic glioma models using 18-fluoromisonidozole positron emission tomography. In addition, we determined tumor response to the hypoxia-activated prodrug evofosfamide (TH-302) in these rat glioma models...
September 2016: Tomography: a Journal for Imaging Research
https://www.readbyqxmd.com/read/27751347/noninvasive-assessment-of-losartan-induced-increase-in-functional-microvasculature-and-drug-delivery-in-pancreatic-ductal-adenocarcinoma
#16
Vidhya Kumar, Yves Boucher, Hao Liu, Diego Ferreira, Jacob Hooker, Ciprian Catana, Andrew J Hoover, Tobias Ritter, Rakesh K Jain, Alexander R Guimaraes
PURPOSE: Losartan, an angiotensin II receptor blocker, can reduce desmoplasia and enhance drug delivery and efficacy through improving interstitial transport and vascular perfusion in pancreatic ductal adenocarcinoma (PDAC) models in mice. The purpose of this study was to determine whether magnetic resonance imaging (MRI) of magnetic iron oxide nanoparticles (MNPs) and micro-positron emission tomography (PET) measurements could respectively detect improvements in tumor vascular parameters and drug uptake in orthotopic PDAC in mice treated with losartan...
October 2016: Translational Oncology
https://www.readbyqxmd.com/read/27747597/quantitative-multimodal-multiparametric-imaging-in-alzheimer-s-disease
#17
Qian Zhao, Xueqi Chen, Yun Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, causing changes in memory, thinking, and other dysfunction of brain functions. More and more people are suffering from the disease. Early neuroimaging techniques of AD are needed to develop. This review provides a preliminary summary of the various neuroimaging techniques that have been explored for in vivo imaging of AD. Recent advances in magnetic resonance (MR) techniques, such as functional MR imaging (fMRI) and diffusion MRI, give opportunities to display not only anatomy and atrophy of the medial temporal lobe, but also at microstructural alterations or perfusion disturbance within the AD lesions...
March 2016: Brain Informatics
https://www.readbyqxmd.com/read/27743299/subacute-cardiac-rubidium-82-positron-emission-tomography-82-rb-pet-to-assess-myocardial-area-at-risk-final-infarct-size-and-myocardial-salvage-after-stemi
#18
Adam Ali Ghotbi, Andreas Kjaer, Lars Nepper-Christensen, Kiril Aleksov Ahtarovski, Jacob Thomsen Lønborg, Niels Vejlstrup, Kasper Kyhl, Thomas Emil Christensen, Thomas Engstrøm, Henning Kelbæk, Lene Holmvang, Lia E Bang, Rasmus Sejersten Ripa, Philip Hasbak
BACKGROUND: Determining infarct size and myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) is important when assessing the efficacy of new reperfusion strategies. We investigated whether rest (82)Rb-PET myocardial perfusion imaging can estimate area at risk, final infarct size, and myocardial salvage index when compared to cardiac SPECT and magnetic resonance (CMR). METHODS: Twelve STEMI patients were injected with (99m)Tc-Sestamibi intravenously immediate prior to reperfusion...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27740992/positron-emission-tomography-and-single-photon-emission-computed-tomography-in-neurology
#19
Robert S Miletich
PURPOSE OF REVIEW: Positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are now available for routine clinical applications in neurology. This article discusses their diagnostic use in dementia, brain tumors, epilepsy, parkinsonism, cerebrovascular disease, and traumatic brain injury. RECENT FINDINGS: Neuromolecular imaging, also known as nuclear neurology, involves clinical imaging of both basal regional physiology (perfusion, metabolism, and transport mechanisms) and specific neurochemical physiology (currently, only the dopamine transporter)...
October 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27740942/effect-of-blood-activity-on-dosimetric-calculations-for-radiopharmaceuticals
#20
Alexandra Zvereva, Nina Petoussi-Henss, Wei Bo Li, Helmut Schlattl, Uwe Oeh, Maria Zankl, Frank Philipp Graner, Christoph Hoeschen, Stephan G Nekolla, Katia Parodi, Markus Schwaiger
The objective of this work was to investigate the influence of the definition of blood as a distinct source on organ doses, associated with the administration of a novel radiopharmaceutical for positron emission tomography-computed tomography (PET/CT) imaging-(S)-4-(3-(18)F-fluoropropyl)-L-glutamic acid ((18)F-FSPG). Personalised pharmacokinetic models were constructed based on clinical PET/CT images from five healthy volunteers and blood samples from four of them. Following an identifiability analysis of the developed compartmental models, person-specific model parameters were estimated using the commercial program SAAM II...
October 14, 2016: Physics in Medicine and Biology
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