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positron emission tomography perfusion

Roberto Sciagrà, Elisa Milan, Raffaele Giubbini, Tomasz Kubik, Rossella Di Dato, Lara Gallo, Luca Camoni, Michela Allocca, Raffaella Calabretta
BACKGROUND: This study examined whether measuring myocardial blood flow (MBF) in the sub-endocardial (SEN) and sub-epicardial (SEP) layers of the left ventricular myocardium using 13 NH3 positron emission tomography (PET) and an automated procedure gives reasonable results in patients with known or suspected coronary artery disease (CAD). METHODS: Resting and stress 13 NH3 dynamic PET were performed in 70 patients. Using ≥ 70% diameter stenosis in invasive coronary angiography (ICA) to identify significant CAD, we examined the diagnostic value of SEN- and SEP-MBF, and coronary flow reserve (CFR) vs...
September 20, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Junliang Yuan, Shuangkun Wang, Wenli Hu
Sporadic Creutzfeldt-Jakob disease (sCJD) is a fatal progressive neurodegenerative disease. Multimodal approaches, including electroencephalogram, diffusion-weighted imaging (DWI) of brain MRI, and cerebrospinal fluid biomarkers, have been applied to increase the diagnostic accuracy of sCJD. Although previous studies suggested DWI could be the most useful modality for sCJD diagnosis, whether metabolism changes underlying in sCJD are still poorly understood. To the best of our knowledge, there are only one case using the technique of arterial spin labeling (ASL) to detection and follow-up of perfusion changes in CJD...
September 18, 2018: Prion
Qinshuo Zhao, Jingqiu Huang, Dong Wang, Liang Chen, Dating Sun, Chunxia Zhao
BACKGROUND: Myocardial infarction (MI) contributes to the development of cardiac remodeling and heart failure. Insufficient post-MI myocardial angiogenesis has been identified as a non-negligible event which precipitates heart failure progression. Previous studies reported that cytochrome P450 epoxygenase and its metabolites exerted beneficial effects on cardiovascular diseases. However, the role of cytochrome P450 2J2 (CYP2J2) in post-MI heart failure is incompletely understood. METHODS AND RESULTS: First, western blot and real-time PCR analyses showed that CYP2J2 expression increased clearly in patients with acute MI and old MI, compared to control...
September 13, 2018: Journal of Molecular and Cellular Cardiology
Michiel J Bom, Roel S Driessen, Pieter G Raijmakers, Henk Everaars, Adriaan A Lammertsma, Albert C van Rossum, Niels van Royen, Juhani Knuuti, Maija Mäki, Ibrahim Danad, Paul Knaapen
Aims: The longitudinal myocardial blood flow (MBF) gradient derived from positron emission tomography (PET) has been proposed as an emerging non-invasive index of haemodynamically significant coronary artery disease (CAD). This study aimed to investigate the diagnostic value of longitudinal MBF gradient for the presence of haemodynamically significant CAD. Methods and results: A total of 204 patients (603 vessels) with suspected CAD underwent [15O]H2O PET followed by invasive coronary angiography with fractional flow reserve (FFR) of all major coronary arteries...
September 12, 2018: European Heart Journal Cardiovascular Imaging
Audrey Katako, Paul Shelton, Andrew L Goertzen, Daniel Levin, Bohdan Bybel, Maram Aljuaid, Hyun Jin Yoon, Do Young Kang, Seok Min Kim, Chong Sik Lee, Ji Hyun Ko
Utilizing the publicly available neuroimaging database enabled by Alzheimer's disease Neuroimaging Initiative (ADNI; ), we have compared the performance of automated classification algorithms that differentiate AD vs. normal subjects using Positron Emission Tomography (PET) with fluorodeoxyglucose (FDG). General linear model, scaled subprofile modeling and support vector machines were examined. Among the tested classification methods, support vector machine with Iterative Single Data Algorithm produced the best performance, i...
September 5, 2018: Scientific Reports
Michael H Chiu, Bobak Heydari, Zarah Batulan, Nadia Maarouf, Vinita Subramanya, Karin Schenck-Gustafsson, Edward R O'Brien
The recognition of sex differences in cardiovascular disease, particularly the manifestations of coronary artery disease (CAD) in post-menopausal women, has introduced new challenges in not only understanding disease mechanisms but also identifying appropriate clinical means of assessing the efficacy of management strategies. For example, the majority of treatment algorithms for CAD are derived from the study of males, focus on epicardial stenoses, and inadequately account for the small intramyocardial vessel disease in women...
September 14, 2018: Clinical Science (1979-)
Serdar Savas Gul, Serkan Gurgul, Murat Uysal, Fikret Erdemir
PURPOSE: The aim of the present study was to show the protective effect of pulsed magnetic field (PMF) application and melatonin administration on damage in testis in a one-sided torsion detorsion induced rat model using testicular scintigraphy with 99mTc pertechnetate, PET/CT with 18F-FDG and histopathological methods. MATERIALS AND METHODS: Sixty male rats were used in the study; 30 rats were randomly divided into five groups for one day applications of sham control, torsion, melatonin, pulsed magnetic field (PMF) and melatonin plus PMF...
September 1, 2018: Urology Journal
Takayuki Chiba, Kengo Setta, Yasuyoshi Shimada, Jun Yoshida, Kentaro Fujimoto, Shouta Tsutsui, Kenji Yoshida, Masakazu Kobayashi, Yoshitaka Kubo, Shunrou Fujiwara, Kazunori Terasaki, Kuniaki Ogasawara
BACKGROUND AND PURPOSE: Adult patients with symptomatically ischemic moyamoya disease (MMD) initially undergo medical treatment alone including antiplatelet drugs when symptomatic cerebral hemispheres do not exhibit hemodynamic compromise. The purpose of the present study subanalyzing the same patient cohort used in a previous study was to determine which antiplatelet drug, clopidogrel or cilostazol, provides better improvement of cerebral perfusion in such patients. METHODS: All patients without cerebral misery perfusion on 15 O gas positron emission tomography (PET) did not undergo revascularization surgery and were treated with medication alone, including antiplatelet therapy...
August 31, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Ali Ahmadi, Rebecca E Thornhill, Elena Pena, Jennifer M Renaud, Steven Promislow, George Chandy, Ross A Davies, Duncan J Stewart, Vladimir Contreras-Dominguez, Rosemary Dunne, Carolyn Doyle-Cox, Rob S Beanlands, Robert A deKemp, Lisa M Mielniczuk
BACKGROUND: The effects of riociguat treatment on right ventricular (RV) metabolism, perfusion, and output in patients with chronic thromboembolic pulmonary hypertension (CTEPH) are unknown. In this study, RV changes associated with riociguat therapy were investigated. METHODS: Six patients with CTEPH received riociguat for 6 months. Right heart catheterization (only baseline), cardiac magnetic resonance imaging, and positron emission tomography using tracers for myocardial glucose uptake (18 F-fluorodeoxyglucose [18 F-FDG]) and perfusion (13 N-ammonia) were performed at baseline and follow-up time points...
September 2018: Canadian Journal of Cardiology
Fabian Rengier, Claudius Melzig, Thorsten Derlin, Alberto M Marra, Jens Vogel-Claussen
Pulmonary hypertension (PH) is a pathophysiological disorder defined by an increase in pulmonary arterial pressure which can occur in multiple clinical conditions. Irrespective of etiology, PH entails a negative impact on exercise capacity and quality of life, and is associated with high mortality particularly in pulmonary arterial hypertension. Noninvasive imaging techniques play an important role in suggesting the presence of PH, providing noninvasive pulmonary pressure measurements, classifying the group of PH, identifying a possibly underlying disease, providing prognostic information and assessing response to treatment...
August 30, 2018: International Journal of Cardiovascular Imaging
Simina Toma, Bradley J MacIntosh, Walter Swardfager, Benjamin I Goldstein
BACKGROUND: Neuroimaging of cerebral blood flow (CBF) can inform our understanding of the pathophysiology of bipolar disorder (BD) as there is increasing support for the concept that BD is in part a vascular disease. Despite numerous studies examining CBF in BD, there has not yet been a review of the literature on the topic of CBF in BD. METHODS: A systematic review of the literature on CBF in BD was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA)...
December 1, 2018: Journal of Affective Disorders
Varvara Valotassiou, Julia Malamitsi, John Papatriantafyllou, Efthimios Dardiotis, Ioannis Tsougos, Dimitrios Psimadas, Sotiria Alexiou, George Hadjigeorgiou, Panagiotis Georgoulias
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia. Beta-amyloid (Aβ) deposition and neurofibrillary tangles (NFTs) of abnormal hyperphosphorylated tau protein are the pathological hallmarks of the disease, accompanied by other pathological processes such as microglia activation. Functional and molecular nuclear medicine imaging with single-photon emission computed tomography (SPECT) and positron emission tomography (PET) techniques provides valuable information about the underlying pathological processes, many years before the appearance of clinical symptoms...
August 20, 2018: Annals of Nuclear Medicine
K Lance Gould, Nils P Johnson, Amanda Roby, Tung T Nguyen, Richard L Kirkeeide, Mary Haynie, Dejian Lai, Hongjian Zhu, Monica B Patel, Richard W Smalling, Salman Arain, Prakash Balan, Nguyet Tom Nguyen, Anthony Estrera, Stefano Sdringola, Mohammad Madjid, Angelo Nascimbene, Pranav Loyalka, Biswajit Kar, Igor Gregoric, Hazim Safi, David McPherson
Rationale: Since randomized coronary revascularization trials in stable CAD have shown no reduced MI or mortality, the threshold of quantitative myocardial perfusion severity was analyzed for association with reduced death, MI or stroke after revascularization within 90 days after PET. Methods: In a prospective long-term cohort of stable CAD, regional, artery specific, quantitative myocardial perfusion by positron emission tomography (PET), coronary revascularization within 90 days after PET and all cause death, myocardial infarction and stroke (DMS) at 9 years follow-up, mean 3...
August 16, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
Dominik A Steffen, Andreas A Giannopoulos, Marvin Grossmann, Michael Messerli, Moritz Schwyzer, Christoph Gräni, Cathérine Gebhard, Aju P Pazhenkottil, Philipp A Kaufmann, Ronny R Buechel
BACKGROUND: A reduction in left ventricular apical tracer uptake (apical thinning) is frequently observed in myocardial perfusion imaging (MPI), yet its cause remains a matter of debate, particularly in perfusion emission tomography (PET). This analysis sought to determine whether apical thinning in PET-MPI is attributable to true anatomical thinning of the left ventricular apical myocardium. METHODS AND RESULTS: We retrospectively analyzed 57 patients without any history or signs of apical myocardial infarction who underwent rest PET-MPI with 13N-ammonia and contrast-enhanced cardiac computed tomography (CT)...
August 14, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Howard J Lee, Jing Zeng, Hubert J Vesselle, Shilpen A Patel, Ramesh Rengan, Stephen R Bowen
PURPOSE: To apply a previously designed framework for predicting radiation pneumonitis by using pretreatment lung function heterogeneity metrics, anatomic dosimetry, and functional lung dosimetry derived from 2 imaging modalities within the same cohort. METHODS AND MATERIALS: Treatment planning computed tomography (CT) scans were co-registered with pretreatment [99m Tc] macro-aggregated albumin perfusion single-photon positron emission tomography (SPECT)/CT scans and [18 F]-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT scans of 28 patients who underwent definitive thoracic radiation...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Fermín Segovia, Manuel Gómez-Río, Raquel Sánchez-Vañó, Juan Manuel Górriz, Javier Ramírez, Eva Triviño-Ibáñez, Cristóbal Carnero-Pardo, María Dolores Martínez-Lozano, Pablo Sopena-Novales
BACKGROUND: Biomarkers of neurodegeneration play a major role in the diagnosis of Alzheimer's disease (AD). Information on both amyloid-β accumulation, e.g., from amyloid positron emission tomography (PET), and downstream neuronal injury, e.g., from 18F-fluorodeoxyglucose (FDG) PET, would ideally be obtained in a single procedure. OBJECTIVE: On the basis that the parallelism between brain perfusion and glucose metabolism is well documented, the objective of this work is to evaluate whether brain perfusion estimated in a dual-point protocol of 18F-florbetaben (FBB) PET can be a surrogate of FDG PET in appropriate use criteria (AUC) for amyloid PET...
2018: Journal of Alzheimer's Disease: JAD
Dong-Yeon Kim, Sang-Geon Cho, Hee-Seung Bom
Myocardial perfusion imaging using positron emission tomography (PET) has several advantages over single photon emission computed tomography (SPECT). The recent advances in SPECT technology have shown promise, but there is still a large need for PET in the clinical management of coronary artery disease (CAD). Especially, absolute quantification of myocardial blood flow (MBF) using PET is extremely important. In spite of considerable advances in the diagnosis of CAD, novel PET radiopharmaceuticals remain necessary for the diagnosis of CAD because clinical use of current cardiac radiotracers is limited by their physical characteristics, such as decay mode, emission energy, and half-life...
August 2018: Nuclear Medicine and Molecular Imaging
Navkaranbir S Bajaj, Michael T Osborne, Ankur Gupta, Ali Tavakkoli, Paco E Bravo, Tomas Vita, Courtney F Bibbo, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Deepak L Bhatt, Marcelo F Di Carli, Viviany R Taqueti
BACKGROUND: Besides body mass index (BMI), other discriminators of cardiovascular risk are needed in obese patients, who may or may not undergo consideration for bariatric surgery. Coronary microvascular dysfunction (CMD), defined as impaired coronary flow reserve (CFR) in the absence of flow-limiting coronary artery disease, identifies patients at risk for adverse events independently of traditional risk factors. OBJECTIVES: The study sought to investigate the relationship among obesity, CMD, and adverse outcomes...
August 14, 2018: Journal of the American College of Cardiology
Etsuko Imabayashi
The Dementia with Lewy Bodies (DLB) Consortium refined its recommendations for the clinical diagnosis of DLB last year. The generalized low uptake of single photon emission computed tomography (SPECT)/positron emission tomography (PET) perfusion/metabolism scan with reduced occipital activity with or without the cingulate island sign (CIS) in FDG-PET imaging was described as a supportive biomarker of DLB. CIS shows that brain metabolism in the posterior cingulate of patients with DLB is relatively preserved compared with Alzheimer's disease (AD)...
August 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
K Egger, M Rijntjes
The differential diagnosis of atypical dementia remains difficult. The use of positron emission tomography (PET) still represents the gold standard for imaging diagnostics. According to the current evidence, however, magnetic resonance imaging (MRI) is almost equal to fluorodeoxyglucose (FDG)-PET, but only when using new big data and machine learning methods. In cases of atypical dementia, especially in younger patients and for follow-up, MRI is preferable to computed tomography (CT). In the clinical routine, promising MRI procedures are e...
August 2018: Der Nervenarzt
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