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positron emission tomography perfusion

Kengo Setta, Daigo Kojima, Yasuyoshi Shimada, Jun Yoshida, Sotaro Oshida, Kentaro Fujimoto, Shouta Tsutsui, Takayuki Chiba, Shunrou Fujiwara, Kazunori Terasaki, Kuniaki Ogasawara
OBJECTIVE: The purpose of the present study was to determine how accurately relative cerebral blood flow (RCBF) and relative cerebrovascular reactivity (RCVR) to acetazolamide assessed using brain perfusion single-photon emission computed tomography (SPECT) detected misery perfusion identified on positron emission tomography (PET) in adult patients with ischemic moyamoya disease (MMD). METHODS: Oxygen extraction fraction (OEF), RCBF, and RCVR were assessed using 15 O gas PET and N-isopropyl-p-[123 I]-iodoamphetamine SPECT without and with acetazolamide challenge, respectively, in 45 patients...
July 20, 2018: Annals of Nuclear Medicine
Yi-He Wang, Yang An, Xiao-Tong Fan, Jie Lu, Lian-Kun Ren, Peng-Hu Wei, Bi-Xiao Cui, Jia-Lin Du, Chao Lu, Di Wang, Hua-Qiang Zhang, Yong-Zhi Shan, Guo-Guang Zhao
Objective: In the detection of seizure onset zones, arterial spin labeling (ASL) can overcome the limitations of positron emission tomography (PET) with 18 F-fluorodeoxyglucose (18 F-FDG), which is invasive, expensive, and radioactive. PET/magnetic resonance (MR) systems have been introduced that allow simultaneous performance of ASL and PET, but comparisons of these techniques with stereoelectroencephalography (SEEG) and comparisons among the treatment outcomes of these techniques are still lacking...
2018: NeuroImage: Clinical
Muhummad Sohaib Nazir, Tevfik F Ismail, Eliana Reyes, Amedeo Chiribiri, Philipp A Kaufmann, Sven Plein
Hybrid positron emission tomography-magnetic resonance (PET-MR) imaging is a novel imaging modality with emerging applications for cardiovascular disease. PET-MR aims to combine the high-spatial resolution morphological and functional assessment afforded by magnetic resonance imaging (MRI) with the ability of positron emission tomography (PET) for quantification of metabolism, perfusion, and inflammation. The fusion of these two modalities into a single imaging platform not only represents an opportunity to acquire complementary information from a single scan, but also allows motion correction for PET with reduction in ionising radiation...
July 12, 2018: European Heart Journal Cardiovascular Imaging
Chen Li, Xuhua Cao, Zhizhao Ma, Xiaofeng Sun, Fuguang Hu, Liqun Wang
BACKGROUND: Extracranial-intracranial (EC-IC) bypass surgery has been used to improve the conditions of cerebral ischemia symptoms for selected patients resulting from diverse complications such as stroke and atherosclerotic disease. However, several clinical trials showed EC-IC bypass surgery failed to prevent recurrent ischemic stroke in certain patients. OBJECTIVE: Our clinical trial aimed to investigate whether there is a correlation between pre-surgery assessments and prognosis of patients received EC-IC bypass operation...
June 28, 2018: Restorative Neurology and Neuroscience
Johanna Reimer, Cornelia Montag, Alexander Schuster, Walter Moeller-Hartmann, Jan Sobesky, Wolf-Dieter Heiss, Olivier Zaro-Weber
BACKGROUND: In acute stroke, the magnetic resonance (MR) imaging-based mismatch concept is used to select patients with tissue at risk of infarction for reperfusion therapies. There is however a controversy if non-deconvolved or deconvolved perfusion weighted (PW) parameter maps perform better in tissue at risk prediction and which parameters and thresholds should be used to guide treatment decisions. METHODS: In a group of 22 acute stroke patients with consecutive MR and quantitative positron emission tomography (PET) imaging, non-deconvolved parameters were validated with the gold standard for penumbral-flow (PF) detection 15O-water PET...
July 13, 2018: Cerebrovascular Diseases
Yi-Fan Zhou, Peng-Cheng Li, Jie-Hong Wu, James Andrew Haslam, Ling Mao, Yuan-Peng Xia, Quan-Wei He, Xu-Xia Wang, Hao Lei, Xiao-Li Lan, Qing Robert Miao, Zhen-Yu Yue, Ya-Nan Li, Bo Hu
Brain tissue survival and functional recovery after ischemic stroke greatly depend on cerebral vessel perfusion and functional collateral circulation in the ischemic area. Semaphorin 3E (Sema3E), one of the class 3 secreted semaphorins, has been demonstrated to be a critical regulator in embryonic and postnatal vascular formation via binding to its receptor PlexinD1. However, whether Sema3E/PlexinD1 signaling is involved in poststroke neovascularization remains unknown. To determine the contribution of Sema3E/PlexinD1 signaling to poststroke recovery, aged rats (18 months) were subjected to a transient middle cerebral artery occlusion...
June 11, 2018: Neurobiology of Aging
G Papanastasiou, M C Williams, M R Dweck, S Mirsadraee, N Weir, A Fletcher, C Lucatelli, D Patel, E J R van Beek, D E Newby, S I K Semple
Kinetic modelling of myocardial perfusion imaging data allows the absolute quantification of myocardial blood flow (MBF) and can improve the diagnosis and clinical assessment of coronary artery disease (CAD). Positron emission tomography (PET) imaging is considered the reference standard technique for absolute quantification, whilst oxygen-15 (15 O)-water has been extensively implemented for MBF quantification. Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) has also been used for MBF quantification and showed comparable diagnostic performance against (15 O)-water PET studies...
May 2018: IEEE Transactions on Radiation and Plasma Medical Sciences
Christina Byrne, Philip Hasbak, Andreas Kjær, Jens Jakob Thune, Lars Køber
Aims: Patients with non-ischaemic systolic heart failure often have reduced myocardial blood flow without significant coronary atherosclerosis. Likewise, patients with atrial fibrillation (AF) have reduced myocardial perfusion during AF compared with sinus rhythm. The aim of this study was to explore whether there is an additive negative effect of AF during scan on the myocardial perfusion in patients with non-ischaemic systolic heart failure. Methods and results: We included 27 young healthy controls and 114 patients with non-ischaemic systolic heart failure to a Rubidium-82 positron emission tomography/computed tomography perfusion scan (23 with AF during scan)...
July 9, 2018: European Heart Journal Cardiovascular Imaging
Louise A E Brown, Sebastian C Onciul, David A Broadbent, Kerryanne Johnson, Graham J Fent, James R J Foley, Pankaj Garg, Pei G Chew, Kristopher Knott, Erica Dall'Armellina, Peter P Swoboda, Hui Xue, John P Greenwood, James C Moon, Peter Kellman, Sven Plein
BACKGROUND: Non-invasive assessment of myocardial ischaemia is a cornerstone of the diagnosis of coronary artery disease. Measurement of myocardial blood flow (MBF) using positron emission tomography (PET) is the current reference standard for non-invasive quantification of myocardial ischaemia. Dynamic myocardial perfusion cardiovascular magnetic resonance (CMR) offers an alternative to PET and a recently developed method with automated inline perfusion mapping has shown good correlation of MBF values between CMR and PET...
July 9, 2018: Journal of Cardiovascular Magnetic Resonance
Otto M Henriksen, Mark Bitsch Vestergaard, Ulrich Lindberg, Niels Jacob Aachmann-Andersen, Kristian Lisbjerg, Søren Just Christensen, Peter Rasmussen, Niels Vidiendal Olsen, Julie L Forman, Henrik Bo Wiberg Larsson, Ian Law
Studies of the resting brain measurements of cerebral blood flow (CBF) show large interindividual and regional variability, but the metabolic basis of this variability is not fully established. The aim of the present study was to reassess regional and interindividual relationship between cerebral perfusion and glucose metabolism in the resting brain. Regional quantitative measurements of CBF and cerebral metabolic rate of glucose (CMRglc ) were obtained in 24 healthy young males using dynamic 15 O-H2 O and 18 F-fluoro-deoxyglucose positron emission tomography (PET)...
July 5, 2018: Journal of Applied Physiology
Thomas Rasmussen, Andreas Kjær, Philip Hasbak
BACKGROUND: 82 Rubidium(82 Rb)-positron-emission-tomography (PET) is prone to some of the same imaging artifacts as single-photon-emission-computed-tomography myocardial perfusion imaging (MPI) including interference from excessive subdiaphragmatic activity. Our aim was to determine associations between clinical parameters and MPI interference including any potential correlation between interference severity and stomach volume. METHODS AND RESULTS: Two hundred men and women fasted two hours prior to standard clinical 82 Rb myocardial perfusion rest/stress PET...
July 2, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
Peder L Myhre, Torbjørn Omland, Sebastian I Sarvari, Heikki Ukkonen, Frank Rademakers, Jan E Engvall, Tor-Arne Hagve, Eike Nagel, Rosa Sicari, Jose L Zamorano, Mark Monaghan, Jan D'hooge, Thor Edvardsen, Helge Røsjø
BACKGROUND: Cardiac troponin T concentrations measured with high-sensitivity assays (hs-cTnT) provide important prognostic information for patients with stable coronary artery disease (CAD). However, whether hs-cTnT concentrations mainly reflect left ventricular (LV) remodeling or recurrent myocardial ischemia in this population is not known. METHODS: We measured hs-cTnT concentrations in 619 subjects with suspected stable CAD in a prospectively designed multicenter study...
June 29, 2018: Clinical Chemistry
Teng Jin, Yan Ren, Hua Zhang, Qian Xie, Zhenwei Yao, Xiaoyuan Feng
Background The diagnosis of a tumor depends on accurate identification of the target area for biopsy. However, tumor heterogeneity and the inability of conventional structural data for identifying the most malignant areas can reduce this accuracy. Purpose To evaluate the feasibility and practicality of magnetic resonance spectroscopy (MRS)- and arterial spin labeling (ASL)-guided MRI navigation for needle biopsy of intracranial tumors. Material and Methods Thirty patients with intracranial tumors who underwent intraoperative stereotactic biopsy were retrospectively analyzed...
January 1, 2018: Acta Radiologica
Thais Coutinho, Lisa M Mielniczuk, Kajenny Srivaratharajah, Robert deKemp, George A Wells, Rob S Beanlands
BACKGROUND: The prognosis of cardiovascular disease is worse in women than men, and coronary microvascular dysfunction explains the excess cardiovascular risk in women. In addition, age-related increases in pulsatile arterial load are greater in women than men; and lower arterial compliance has been shown to independently predict cardiovascular events. However, whether arterial load differentially affects the coronary microvasculature in men and women remains unknown. We hypothesized that lower arterial compliance would be associated with coronary artery microvascular dysfunction in women...
June 20, 2018: International Journal of Cardiology
Opstal Tsj, Knol Rjj, Cornel Jh, Wondergem M, van der Zant Fm
Background: Cardiac imaging by means of myocardial Positron Emission Tomography/Computed Tomography (PET/CT) is being used increasingly to assess coronary artery disease, to guide revascularization decisions with more accuracy, and it allows robust quantitative analysis of both regional myocardial blood flow (MBF) and myocardial flow reserve (MFR).Recently, a more time-efficient protocol has been developed in combination with a residual activity correction algorithm in which a stress acquisition is performed directly after completion of the rest acquisition to subtract remaining myocardial radioactivity...
2018: European journal of hybrid imaging
Valeria Romeo, Brigida Iorio, Massimo Mesolella, Lorenzo Ugga, Francesco Verde, Emanuele Nicolai, Mario Covello
The purpose of the study was to assess by simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) the response to chemotherapy (CHT) and/or radiotherapy (RT) in patients with head and neck squamous cell carcinoma (HNSCC). Five patients with HNSCC underwent simultaneous PET/MRI examination before and after CHT and/or RT. Standard uptake volume (SUV), apparent diffusion coefficient (ADC), Ktrans, Kep, Ve, and iAUC pre- and post-treatment values were extracted and compared. The response to treatment was assessed according to RECIST criteria and classified as complete response (CR), partial response (PR), stable disease (SD), and progression disease (PD)...
June 19, 2018: Medical Oncology
Ismet Sarikaya, A H Elgazzar, M A Alfeeli, P N Sharma, A Sarikaya
Objective: F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) has been increasingly used in myocardial viability imaging. In routine PET viability studies, oral glucose and intravenous insulin loading is commonly utilized. In an optimal study, glucose and insulin loading is expected to cause FDG uptake both in hibernating and normal myocardium. However, in routine studies it is not uncommon to see absent or reduced FDG uptake in normal myocardium. In this retrospective study we further analyzed our PET viability images to evaluate FDG uptake status in myocardium under the oral glucose and intravenous insulin loading protocol that we use in our hospital...
April 2018: Journal of the Saudi Heart Association
Johanna Päivärinta, Niina Koivuviita, Vesa Oikonen, Hidehiro Iida, Kaisa Liukko, Ilkka Manner, Eliisa Löyttyniemi, Pirjo Nuutila, Kaj Metsärinne
BACKGROUND: Microvascular function plays an important role in ARVD (atherosclerotic renovascular disease). RFR (renal flow reserve), the capacity of renal vasculature to dilate, is known to reflect renal microvascular function. In this pilot study, we assessed PET (positron emission tomography)-based RFR values of healthy persons and renal artery stenosis patients. Seventeen patients with ARVD and eight healthy subjects were included in the study. Intravenous enalapril 1 mg was used as a vasodilatant, and the maximum response (blood pressure and RFR) to it was measured at 40 min...
June 11, 2018: EJNMMI Research
Carolina A Ferreira, Reinier Hernandez, Yunan Yang, Hector F Valdovinos, Jonathan W Engle, Weibo Cai
Peripheral arterial disease (PAD) consists of a persistent obstruction of lower-extremity arteries further from the aortic bifurcation attributable to atherosclerosis. PAD is correlated with an elevated risk of morbidity and mortality as well as of deterioration of the quality of life with claudication and chronic leg ischemia being the most frequent complications. Therapeutic angiogenesis is a promising therapeutic strategy that aims to restore the blood flow to the ischemic limb. In this context, assessing the efficacy of pro-angiogenic treatment using a reliable noninvasive imaging technique would greatly benefit the implementation of this therapeutic approach...
June 25, 2018: Molecular Pharmaceutics
Marc G Stevenson, Lukas B Been, Harald J Hoekstra, Albert J H Suurmeijer, Ronald Boellaard, Adrienne H Brouwers
BACKGROUND: This study explores various volume of interest (VOI) delineation techniques for fluorine-18-fluorodeoxyglucose positron emission tomography with computed tomography (18 F-FDG PET-CT) scans during neoadjuvant extremity soft tissue sarcoma (ESTS) treatment. RESULTS: During neoadjuvant treatment, hyperthermic isolated limb perfusion (HILP) and preoperative external beam radiotherapy (EBRT), 11 patients underwent three 18 F-FDG PET-CT scans. The first scan was made prior to the HILP, the second after the HILP but prior to the start of the EBRT, and the third prior to surgical resection...
June 7, 2018: EJNMMI Research
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