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https://www.readbyqxmd.com/read/29792379/role-of-s-100%C3%AE-in-stroke
#1
Yongli He, Zhiyou Cai, Yangmei Chen
The S-100β levels are associated with a variety of acute disorders and other chronic diseases, such as head injury, stroke, metastatic melanoma, cardiac surgery, bone fractures, burns and contusions. The serum S-100β levels seem to increase with the volume of tissue damage. The higher serum S-100β levels have been observed after brain damage or stroke. A number of studies have evidenced the clinical value of S-100β in the diagnosis and prognosis of stroke while the S-100β marker is elevated in the peripheral blood during the acute phase of stroke...
May 24, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29791543/rapidly-growing-pulmonary-ground-glass-nodule-caused-by-metastatic-melanoma-lacking-uptake-on-18f-fdg-pet-ct
#2
Giorgia Dalpiaz, Sofia Asioli, Stefano Fanti, Gaetano Rea, Edson Marchiori
No abstract text is available yet for this article.
April 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29790922/artificial-intelligence-for-melanoma-diagnosis-how-can-we-deliver-on-the-promise
#3
V J Mar, H P Soyer
No abstract text is available yet for this article.
May 22, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29790899/advances-in-the-systemic-treatment-of-melanoma-brain-metastases
#4
I C Glitza Oliva, G Schvartsman, H Tawbi
Of the solid tumor types that metastasize to the brain, melanoma has the highest propensity to form brain metastases. In addition, much remains unknown regarding the pathophysiology involved in melanoma cell extravasation through the blood-brain barrier, which enables interactions with the microenvironment, and melanoma cell transcriptomic responses to brain-specific cues. However, recent developments in targeted therapy and immunotherapy have generated considerable optimism regarding the treatment of metastatic melanoma...
May 22, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29790606/the-significance-of-spectrophotometric-image-analysis-for-diagnosis-of-the-melanocytic-skin-tumours-in-association-with-their-thickness
#5
K Sakalauskienė, S Valiukevičienė, R Raišutis, G Linkevičiūtė
BACKGROUND: Cutaneous melanoma is a melanocytic skin tumour, which has very poor prognosis while it is highly resistant to treatment and tends to metastasize. Thickness of melanoma is one of the most important biomarker for stage of disease, prognosis and surgery planning. In this study, we hypothesized that the analysis of spectrophotometric (SIAscope) images can provide the information about skin tumour thickness. METHODS: The intensity of blood displacement, "erythematous blush", collagen holes, intensity of collagen, dermal and epidermal melanin were estimated in SIAgraphs...
May 23, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29790264/immune-responses-against-tumor-associated-antigen-derived-cytotoxic-t-lymphocyte-epitopes-in-cholangiocarcinoma-patients
#6
Akihiko Kida, Eishiro Mizukoshi, Toshikatsu Tamai, Takeshi Terashima, Masaaki Kitahara, Kuniaki Arai, Tatsuya Yamashita, Kazumi Fushimi, Masao Honda, Shuichi Kaneko
BACKGROUND & AIMS: Immunotherapy is a promising treatment option for cholangiocarcinoma. We compared cytotoxic T lymphocyte (CTL) responses against several tumor-associated antigen (TAA)-derived epitopes in cholangiocarcinoma patients to identify candidate epitopes for immunotherapy. METHODS: Twenty-six TAAs were selected, and the expression of TAAs in 6 cholangiocarcinoma cell lines and 9 specimens were measured using real-time polymerase chain reaction (PCR)...
May 23, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29790147/sensitivity-and-specificity-of-ex-vivo-dermatoscopy-a-case-series
#7
Danijela Dobrosavljevic, Dimitrije Brasanac, Sofija Glumac, Sanja Radojevic, Lidija Matija, Dejana Stanisavljevic
BACKGROUND: Sensitivity and specificity of ex vivo dermatoscopy (EVD) for malignancy detection of skin tumors is unknown. We sought to assess whether the use of EVD could be a useful adjunct to histopathological diagnosis of pigmented skin tumors, including cases where complete clinical information is inadequate or missing. MATERIALS AND METHODS: EVD was performed on 195 excised, formalin-fixed pigmented skin tumors. RESULTS: Of 183 eligible lesions, 104 (56...
May 23, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29790020/can-we-accurately-predict-cost-effectiveness-without-access-to-overall-survival-data-the-case-study-of-nivolumab-in-combination-with-ipilimumab-for-the-treatment-of-patients-with-advanced-melanoma-in-england
#8
D Lee, A Amadi, J Sabater, J Ellis, H Johnson, S Kotapati, S McNamara, A Walker, M Cooper, K Patterson, N Roskell, Y Meng
BACKGROUND: Nivolumab with ipilimumab (the Regimen) is the first immuno-oncology combination treatment to demonstrate long-term clinical benefit for advanced melanoma patients. We evaluated the cost effectiveness of the Regimen in this population, with and without the availability of overall survival (OS) data. METHODS: A partitioned survival model and a Markov state-transition model were developed to estimate the lifetime costs and benefits of the Regimen versus ipilimumab...
May 22, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29790012/evaluation-of-a-nanocomposite-of-peg-curcumin-gold-nanoparticles-as-a-near-infrared-photothermal-agent-an-in-vitro-and-animal-model-investigation
#9
F Rahimi-Moghaddam, N Azarpira, N Sattarahmady
Hyperthermia is a promising alternative modality for the conventional cancer treatments. Nanoparticle-mediated photothermal therapy (PTT) has been widely applied for hyperthermia cancer therapy by a near-infrared light irradiation. Some special nanoparticles can convert light energy into heat and destroy the tumor cells. Inspired from the photothermal efficacy of the gold nanoparticles, here we synthesized, characterized, and applied novel photothermal polyethylene glycol-curcumin-gold nanoparticles (PEG-Cur-Au NPs) in cancer PTT...
May 22, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29789761/visual-outcome-after-posterior-uveal-melanoma-episcleral-brachytherapy-including-radiobiological-doses
#10
David Miguel, Jesús María de Frutos-Baraja, Francisco López-Lara, María Antonia Saornil, Ciro García-Alvarez, Pilar Alonso, Patricia Diezhandino
Purpose: To assess the long-term influence of radiobiological doses in the evolution of visual acuity (VA) in patients with uveal melanoma treated by episcleral brachytherapy. Material and methods: Visual acuity was evaluated prospectively from a case series of 243 patients in 2016 treated with 125 I. Data analysis was applied to trend VA outcome and find the accurate best-fit line. Biologically effective dose (BED) was included in survival analysis with the use of Kaplan-Meier and Cox regressions...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789760/high-dose-rate-brachytherapy-in-treatment-of-non-melanoma-skin-cancer-of-head-and-neck-region-preliminary-results-of-a-prospective-single-institution-study
#11
Bita Kalaghchi, Ebrahim Esmati, Reza Ghalehtaki, Marzieh Gomar, Ramin Jaberi, Soraya Gholami, Somayyeh Babaloui, Mansoureh Nabavi, Sarvazad Sotoudeh, Nezhat Khanjani, Ali Kazemian, Farnaz Amouzegar-Hashemi, Mahdi Aghili, Marzieh Lashkari
Purpose: Skin cancers are the most common human malignancy with increasing incidence. Currently, surgery is standard of care treatment for non-melanoma skin cancers. However, brachytherapy is a growing modality in the management of skin cancers. Therefore, we aimed to assess the outcome of patients with non-melanoma skin cancers treated by high-dose-rate (HDR) brachytherapy with surface mold technique. Material and methods: In this prospective study, we recruited patients with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the skin who were candidates for definitive or adjuvant brachytherapy during 2013-2014...
April 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29789400/carnosic-acid-impedes-cell-growth-and-enhances-anti-cancer-effects-of-carmustine-and-lomustine-in-melanoma
#12
Kun-I Lin, Chih-Chien Lin, Shyh-Ming Kuo, Jui-Chi Lai, You-Qi Wang, Huey-Ling You, Mei-Ling Hsu, Chang-Han Chen, Li Yen Shiu
Background: Carnosic acid (CA), a major polyphenolic diterpene present in Rosmarinus officinalis , has been reported to have multiple functions, including anti-tumor activity. Methods: The MTT assay, BrdU incorporation, wound healing, and colony formation were used to detect melanoma B16F10 cell growth and proliferation. Flow cytometry was used for cell cycle detection. p21 and p27 expression was detected by Western blotting. B16F10 cell xenograft model was established, and treated with CA, carmustine (BCNU), or lomustine (CCNU)...
May 22, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29789324/smoking-and-cutaneous-melanoma-findings-from-the-qskin-sun-and-health-cohort-study
#13
Jean Claude Dusingize, Catherine M Olsen, Nirmala Pandeya, Bridie S Thompson, Penelope M Webb, Adèle C Green, Rachel E Neale, David C Whiteman
BACKGROUND: Previous studies suggest that smokers have lower risks of cutaneous melanoma than non-smokers, but data from population-based prospective studies are scarce. We investigated associations between smoking and melanoma in a cohort study purpose-designed to investigate skin cancer outcomes. METHODS: Participants with no prior history of melanoma (n=38,697) completed a risk factor survey at baseline (2011). Patients were followed through linkage to the cancer registry...
May 22, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29789104/functionalized-caprolactone-polyethylene-glycol-based-thermo-responsive-hydrogels-of-silibinin-for-the-treatment-of-malignant-melanoma
#14
Behzad Sharif Makhmalzadeh, Ommoleila Molavi, Mohammad Reza Vakili, Hai-Feng Zhang, Amir Solimani, Hoda Soleymani Abyaneh, Raimar Loebenberg, Raymond Lai, Afsaneh Lavasanifar
PURPOSE: Silibinin, is a natural compound, which has shown anticancer activity in various malignancies. In this study, we evaluated the anticancer effects of silibinin in B16-F10 melanoma cells and developed a novel thermoresponsive hydrogel for local delivery of this compound. METHOD: A thermoresponsive hydrogel loaded with silibinin was prepared using triblock copolymers of poly[(α-benzyl carboxylate-e-caprolactone)-co-(α-carboxyl-e-caprolactone)]ran-b-PEG-b-[(α-benzyl carboxylate-e-caprolactone) -co-(α-carboxyl-e-caprolactone)]ran (PCBCL-b-PEG-b-PCBCL), namely PolyGelTM, and compared with a Pluronic F-127 formulation of silibinin...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29788760/regression-patterns-of-choroidal-melanoma-after-palladium-103-103-pd-plaque-brachytherapy
#15
Abhilasha Maheshwari, Paul T Finger
PURPOSE: To describe the patterns of regression of choroidal melanoma after treatment with plaque brachytherapy. METHODS: Retrospective interventional case series including 170 consecutive patients treated with 103 Pd eye plaque radiation for choroidal melanoma. Outcome measures were changes in tumor thickness, surface characteristics, tumor vascularity, ultrasonography, fluorescein angiography, optical coherence tomography, and histopathology. RESULTS: The mean initial tumor thickness was 3...
May 1, 2018: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29787509/use-of-moulage-to-evaluate-student-assessment-of-skin-in-an-objective-structured-clinical-examination
#16
Jennifer Zorn, Jennifer Snyder, Jennifer Guthrie
PURPOSE: This study investigated the physician assistant (PA) student evaluation of skin and the use of moulage in an objective structured clinical examination (OSCE). METHODS: Clinical-year PA students participated in an OSCE, taking a history, completing a physical examination, and writing a focused clinical note. The standardized patient's history simulated a primary diagnosis of right-sided carpal tunnel syndrome and an incidental skin lesion consistent with melanoma, only if the student made an inquiry in this replication study...
June 2018: Journal of Physician Assistant Education
https://www.readbyqxmd.com/read/29787460/unmet-information-needs-of-patients-with-melanoma-in-germany
#17
Julia Brütting, Maike Bergmann, Marlene Garzarolli, Ricarda Rauschenberg, Christiane Weber, Carola Berking, Wolfgang Tilgen, Dirk Schadendorf, Friedegund Meier
There is a scarcity of available data on unmet information needs (UINs) of melanoma patients (MPs) from Germany and of MPs with clinical stage IV. In a multicenter cross-sectional survey, we explored the UINs of 529 MPs by applying a standardized questionnaire. Subgroup differences in scope and contents of UINs were determined by univariate analyses. Predictors of the presence of UINs were identified by binary logistic regression. Overall, 55% of MPs reported UINs. Most MPs felt poorly or not informed about psychosocial support (24-31%)...
May 21, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29786976/multiple-acquired-pigmented-lesions-in-a-patient-affected-by-melanoma
#18
Francesco Savoia, Michela Tabanelli, Antonio Ascari Raccagni, Emilia Crisanti, Ignazio Stanganelli, Domenico Piccolo
No abstract text is available yet for this article.
May 22, 2018: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29786888/injectable-bioresponsive-gel-depot-for-enhanced-immune-checkpoint-blockade
#19
Shuangjiang Yu, Chao Wang, Jicheng Yu, Jinqiang Wang, Yue Lu, Yuqi Zhang, Xudong Zhang, Quanyin Hu, Wujin Sun, Chaoliang He, Xuesi Chen, Zhen Gu
Although cancer immunotherapy based on immune checkpoint inhibitors holds great promise toward many types of cancers, several challenges still remain, associated with low objective response of patient rate as well as systemic side effects. Here, a combination immunotherapy strategy is developed based on a thermogelling reactive oxygen species (ROS)-responsive polypeptide gel for sustained release of anti-programmed cell death-ligand 1 antibody and dextro-1-methyl tryptophan, inhibitor of indoleamine-2,3-dioxygenase with leveraging the ROS level in the tumor microenvironment...
May 22, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29786848/annual-report-to-the-nation-on-the-status-of-cancer-part-i-national-cancer-statistics
#20
Kathleen A Cronin, Andrew J Lake, Susan Scott, Recinda L Sherman, Anne-Michelle Noone, Nadia Howlader, S Jane Henley, Robert N Anderson, Albert U Firth, Jiemin Ma, Betsy A Kohler, Ahmedin Jemal
BACKGROUND: The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate to provide annual updates on cancer occurrence and trends in the United States. METHODS: Incidence data were obtained from the CDC-funded and NCI-funded population-based cancer registry programs and compiled by NAACCR. Data on cancer deaths were obtained from the National Center for Health Statistics National Vital Statistics System...
May 22, 2018: Cancer
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