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Nina Milevoj, Urša Lampreht Tratar, Ana Nemec, Andreja Brožič, Katarina Žnidar, Gregor Serša, Maja Čemažar, Nataša Tozon
The aim of this study was to evaluate the safety and efficacy of the combination of electrochemotherapy (ECT) with bleomycin and gene electrotransfer (GET) of plasmid encoding canine interleukin 12 (IL-12) for the treatment of canine oral malignant melanoma (OMM). Our focus was to determine the effect of the treatment on achieving local tumor control and stimulation of an antitumor immune response. Nine dogs with histologically confirmed OMM stage I to III were included in a prospective, non-randomized study...
November 12, 2018: Research in Veterinary Science
Aithne Atkinson, Alexander Renziehausen, Hexiao Wang, Cristiana Lo Nigro, Laura Lattanzio, Marco Merlano, Bhavya Rao, Lynda Weir, Alan Evans, Rubeta Matin, Catherine Harwood, Peter Szlosarek, J Geoffrey Pickering, Colin Fleming, Van Ren Sim, Su Li, James T Vasta, Ronald T Raines, Mathieu Boniol, Alastair Thompson, Charlotte Proby, Tim Crook, Nelofer Syed
Appropriate post-translational processing of collagen requires prolyl hydroxylation, catalyzed by the prolyl 3- (C-P3H) and prolyl 4- (C-P4H) hydroxylases is essential for normal cell function. Here we have investigated the expression, transcriptional regulation and function of the C-P3H and C-P4H families in melanoma. We show that the CP3H family exemplified by Leprel1 and Leprel2 are subject to methylation-dependent transcriptional silencing in primary and metastatic melanoma consistent with a tumour suppressor function...
November 16, 2018: Journal of Investigative Dermatology
Akram Obiedat, Einat Seidel, Mohamed Mahameed, Orit Berhani, Pinchas Tsukerman, Konstantinos Voutetakis, Aristotelis Chatziioannou, Mari McMahon, Tony Avril, Eric Chevet, Ofer Mandelboim, Boaz Tirosh
The unfolded protein response (UPR) is an adaptive signaling pathway activated in response to endoplasmic reticulum (ER) stress. The effectors of the UPR are potent transcription activators; however, some genes are suppressed by ER stress at the mRNA level. The mechanisms underlying UPR-mediated gene suppression are less known. Exploration of the effect of UPR on NK cells ligand expression found that the transcription of NK group 2 member D (NKG2D) ligand major histocompatibility complex class I polypeptide-related sequence A/B (MICA/B) is suppressed by the inositol-requiring enzyme 1 (IRE1)/X-box binding protein 1 (XBP1) pathway of the UPR...
November 19, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Hiroki Kuroda, Masanori Tachikawa, Yuta Yagi, Mina Umetsu, Armania Nurdin, Eisuke Miyauchi, Michitoshi Watanabe, Yasuo Uchida, Tetsuya Terasaki
Brain metastasis is a frequent complication of cancer, and may be mediated at least in part by the internalization of cancer-cell-derived exosomes into brain capillary endothelial cells. Clarifying the mechanism(s) of this internalization is of interest because it could help us to develop ways to block brain metastasis, as well as affording a potential new route for drug delivery into the brain. Therefore, the purpose of the present study was to address this issue by identifying the receptors involved in the internalization of exosomes derived from a brain-metastatic cancer cell line (SK-Mel-28) into human blood-brain barrier endothelial cells (hCMEC/D3 cells)...
November 19, 2018: Molecular Pharmaceutics
Qingqing Yu, Yiming Han, Xiaocheng Wang, Chen Qin, Dong Zhai, Zhengfang Yi, Jiang Chang, Yin Xiao, Chengtie Wu
No abstract text is available yet for this article.
November 19, 2018: ACS Nano
Peter Barth, Jorge J Castillo, Adam J Olszewski
BACKGROUND: Therapeutic advances have extended survival for patients with myeloma, who may develop secondary cancers. METHODS: Using the population-based Surveillance, Epidemiology, and End Results registry (2004-2015), the authors examined the characteristics, overall and cause-specific survival, and cumulative incidence function of cancer-related death among patients with myeloma with secondary cancers of the breast, prostate, lung, colon/rectum, or bladder or melanoma...
November 19, 2018: Cancer
Lijia Luo, Chuang Liu, Tao He, Leyong Zeng, Jie Xing, Yuanzhi Xia, Yuanwei Pan, Changyang Gong, Aiguo Wu
Currently, cancer immunotherapy appears to be an effective strategy for cancer therapy, but the state of unresponsiveness to tumor antigenic stimulation in immune systems is one of the stumbling blocks to the clinical applications of cancer immunotherapy. Nanomaterials have been increasingly applied in cancer immunotherapy by virtue of their irreplaceable superiority to carry antigens to specific sites and stimulate immune responses. Among the many excellent fluorescent nanomaterials, carbon dots (CDs) stand out from the others as a result of their extraordinary performance...
November 19, 2018: Nanoscale
Kejia Wu, Wen Wang, Yaqi Ye, Junhong Huang, Yinghui Zhou, Yue Zhang, Xuewenjun Zhang, Wenyu Wu
Cutaneous melanoma is an aggressive form of skin cancer that causes death worldwide. Although much has been learned about the molecular basis of melanoma genesis and progression, there is also increasing appreciation for the continuing discovery of melanoma genes to improve the genetic understanding of this malignancy. In the present study, melanoma candidate genes were identified by analysis of the common network from cancer type-specific RNA-Seq co-expression data and protein-protein interaction profiles...
November 16, 2018: Melanoma Research
Simona Romano, Paolo D'Arrigo, Martina Tufano, Stefania Staibano, Anna Rea, Francesco Merolla, Gennaro Ilardi, Antonello Petrella, Maria F Romano
Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine, whose role in melanoma is controversial. Although high-dose TNF-α is approved for the treatment of patients with in transit-metastatic melanoma confined to the limb, diverse preclinical models of melanoma have shown that TNF-α can induce cell invasion. Biomarkers that can differentiate between the dual role of TNF-α are needed. TRAF2 is critical to TNF receptor-induced activation of nuclear factor-κB (NF-κB), allowing shifting from death to survival-signaling cascades...
November 16, 2018: Melanoma Research
Vincas Urbonas, Giedre Smailyte, Greta V Urbonaite, Audrius Dulskas, Neringa Burokiene, Vytautas Kasiulevicius
Changes in the expression of proteins on cancer cell surface are a typical outcome of malignant transformation. Natural killers (NKs) utilize a set of activating and inhibitory receptors that enable them to recognize altered protein expression and then destroy 'stressed' cells such as cancer or virus-infected cells. Major histocompatibility complex class I polypeptide-related sequence A and B (MICA and MICB, respectively) are expressed by various human tumors and can be recognized by activating NK cell receptor NKG2D...
November 16, 2018: Melanoma Research
Anne Montfort, Céline Colacios, Thierry Levade, Nathalie Andrieu-Abadie, Nicolas Meyer, Bruno Ségui
No abstract text is available yet for this article.
October 2018: Médecine Sciences: M/S
Camille Fourneaux, Bertrand Dubois
No abstract text is available yet for this article.
October 2018: Médecine Sciences: M/S
H W Higgins, E Cho, M A Weinstock, T Y Li, A Qureshi, W Q Li
BACKGROUND: Our understanding of the relationship between ultraviolet radiation exposure and lentigo maligna (LM) has been largely derived from epidemiologic/clinical studies based on invasive melanoma. Recent studies have shown gender differences in melanocytic tumors incidence. OBJECTIVE: To examine the association of UV light with LM by gender remains unclear. METHODS: Two prospective cohort study (Nurses' Health Study [1980-2012]) and (Health-Professionals Follow-up Study [1986-2010]) were analyzed...
November 19, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
M Potrony, J A Puig-Butille, M Ribera-Sola, V Iyer, C D Robles-Espinoza, P Aguilera, C Carrera, J Malvehy, C Badenas, M T Landi, D J Adams, S Puig
BACKGROUND: Germline mutations in telomere-related genes such as POT1 and the TERT promoter predispose to familial melanoma. OBJECTIVE: To evaluate the prevalence of germline mutations in the POT1 gene and in the TERT promoter in a large cohort of Spanish melanoma-prone families (at least two affected individuals in first- or second-degree relatives). METHODS: Overall, 228 CDKN2A wild-type melanoma-prone families were included in the study...
November 19, 2018: British Journal of Dermatology
Izabela Łasiñska, Jacek Mackiewicz
Despite the great progress in the development of targeted therapies for different types of cancer utilizing monoclonal antibodies (e.g., cetuximab for colorectal cancer and head and neck cancer therapy), kinase inhibitors (e.g., sorafenib for kidney cancer and gastrointestinal stromal tumours therapy), and immunomodulatory treatments (e.g., nivolumab and pembrolizumab for melanoma therapy and lung cancer therapy), there is still a need to search for new, more effective treatments. Integrins are responsible for intercellular adhesion and interacting with the cellular matrix...
November 18, 2018: Anti-cancer Agents in Medicinal Chemistry
Rong-Hui Tan, Feng Wang, Chuan-Long Fan, Xiao-Hong Zhang, Jin-Shun Zhao, Jin-Jie Zhang, Yong Yang, Yang Xi, Zu-Quan Zou, Shi-Zhong Bu
Melanoma is a malignant tumor that arises from epidermal melanocytes with high morbidity and mortality, and currently, there are no effective conventional genotoxic treatments or systematic treatment. Increasing evidence shows that n-3 polyunsaturated fatty acids (PUFAs) exhibit anti-melanoma activity, but their anti-melanoma mechanism remains elusive. Here, C57BL/6 mice were injected with B16F10 melanoma cells via a tail vein to establish a lung metastasis model. n-3 PUFAs were significantly increased in lung metastatic tissues from mice treated with algal oil, especially rich in docosahexaenoic acid (DHA)...
November 19, 2018: Food & Function
María B Pampena, Holliday C Cartar, Gerardo Rubén Cueto, Estrella M Levy, Paula A Blanco, María M Barrio, José Mordoh
As cutaneous melanoma (CM) currently remains with a bleak prognosis, thorough investigation of new treatment options are of utmost relevance. In the phase II/III randomized clinical trial (CASVAC-0401), the repeated immunization of stages IIB-III CM patients with the irradiated, allogeneic cellular CSF-470 vaccine plus the adjuvants bacillus Calmette-Guerin (BCG) and recombinant human granulocyte macrophage colony-stimulating factor (rhGM-CSF) demonstrated a significant benefit over IFN-alpha2B treatment in distant metastasis-free survival...
2018: Frontiers in Immunology
Noriho Sakamoto, Hiroshi Ishimoto, Shota Nakashima, Hirokazu Yura, Takuto Miyamura, Daisuke Okuno, Atsuko Hara, Takeshi Kitazaki, Tomoyuki Kakugawa, Yuji Ishimatsu, Minoru Satoh, Hiroshi Mukae
Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is associated with rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) or dermatomyositis (DM). We herein report three Japanese cases of anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM. High-resolution computed tomography revealed patchy or subpleural distribution of consolidations and/or ground-glass opacities accompanied by traction bronchiectasis. All patients succumbed to respiratory failure within two months...
November 19, 2018: Internal Medicine
Ayumu Takahashi, Akihito Kubo, Shohei Mizuno, Kenji Kasai, Nobuhiro Asai, Toshiyuki Yonezawa, Kenshi Kosaka, Masaki Nishimura, Hiroyuki Tanaka, Norihito Yokoe, Toyonori Tsuzuki, Akiyoshi Takami, Etsuro Yamaguchi
A 73-year-old man who was a current smoker complained of weakness in his limbs and slow movement and was diagnosed with primary lung melanoma with brain metastases. Following stereotactic brain radiotherapy, nivolumab was administrated. After the first cycle of nivolumab, his blood neutrophil count and hemoglobin levels started to decline. Excluding other possible causes, nivolumab was considered the most probable cause of bicytopenia. Nivolumab was not restarted, and the bicytopenia gradually recovered with no corticosteroid administration for this event...
November 19, 2018: Internal Medicine
Takeshi Saraya, Masachika Fujiwara, Kikuko Morita, Takayasu Watanabe, Yukari Ogawa, Hajime Takizawa, Richard W Light
A 51-year-old man was diagnosed with stage IIC nodular malignant melanoma (T4bN0M0) of the right upper arm. The tumor was treatment-refractory, and left-sided pleural effusion emerged 1.5 years later. Aspiration of pleural fluid revealed abundant amelanotic, atypical cells that resembled epithelial malignant mesothelioma or lung adenocarcinoma cells; these cells were positive for melanoma-associated antigen recognized by T cells (MART-1)/Melan-A, HMB-45, and S-100 on immunocytochemistry. Thoracic computed tomography (CT) revealed marked diffuse pleural thickening in the left hemithorax that mimicked malignant mesothelioma; thus, the present report describes the unique cytological and radiological findings of this case...
November 19, 2018: Internal Medicine
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