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https://www.readbyqxmd.com/read/28470749/noninvasive-imaging-systems-for-gametes-and-embryo-selection-in-ivf-programs-a-review
#1
REVIEW
Marjan Omidi, Azita Faramarzi, Azam Agharahimi, Mohammad Ali Khalili
Optimizing the efficiency of the in vitro fertilization procedure by improving pregnancy rates and reducing the risks of multiple pregnancies simultaneously are the primary goals of the current assisted reproductive technology program. With the move to single embryo transfers, the need for more cost-effective and noninvasive methods for embryo selection prior to transfer is paramount. These aims require advancement in a more acquire gametes/embryo testing and selection procedures using high-tech devices. Therefore, the aim of the present review is to evaluate the efficacy of noninvasive imaging systems in the current literatures, focusing on the potential clinical application in infertile patients undergoing assisted reproductive technology treatments...
May 4, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28456372/uterine-peristalsis-and-fertility-current-knowledge-and-future-perspectives-a-review-and-meta-analysis
#2
REVIEW
Nienke Petronella Maria Kuijsters, Willem Gerardus Methorst, Madeleine Susanne Quirine Kortenhorst, Chiara Rabotti, Massimo Mischi, Benedictus Christiaan Schoot
Although uterine contractions in the non-pregnant uterus have been studied extensively, the knowledge gained has not been used in general fertility treatment work-up. In this review paper, we provide an overview of the current knowledge on uterine peristalsis (UP), based on the available literature. This literature shows that UP influences pregnancy chances in both natural and artificial cycles. Although the physiological background of these contractions is not completely clear, we know that several factors can be of influence, like uterine pathologies and hormones...
April 12, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28447444/maternal-thyroid-function-in-women-undergoing-controlled-ovarian-hyperstimulation-during-in-vitro-fertilization-and-its-relation-to-reproductive-outcome
#3
Abdul K Abdul Karim, Muhammad Azrai Abu, Buvanes Chelliah, Zainul R Mohd Razi, Mohd H Omar, Hanita Othman, Zuraidah C Man
BACKGROUND: We conducted a study to evaluate the changes in thyroid function during Controlled Ovarian Hyperstimulation (COH) and its association with the outcome of assisted reproductive technique (ART). METHODS: This is a prospective cohort study done in University Hospital Fertility clinic for one year duration. A total of eighty eight euthyroid women who underwent COH as part of planned in vitro fertilization were invited to participate in this study. Serum thyroid function of each women will be monitored before stimulation (T1), day 10 -13 of cycle (T2), during oocyte retrieval (T3), one week following embryo transfer (T4) and at four weeks post embryo transfer(T5)...
April 26, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28444499/hair-trace-element-and-electrolyte-content-in-women-with-natural-and-in-vitro-fertilization-induced-pregnancy
#4
Anatoly V Skalny, Alexey A Tinkov, Irina Voronina, Olga Terekhina, Margarita G Skalnaya, Yulia Kovas
The objective of the present study was to perform comparative analysis of hair trace element content in women with natural and in vitro fertilization (IVF)-induced pregnancy. Hair trace element content in 33 women with IVF-induced pregnancy and 99 age- and body mass index-matched control pregnant women (natural pregnancy) was assessed using inductively coupled plasma mass spectrometry. The results demonstrated that IVF-pregnant women are characterized by significantly lower hair levels of Cu, Fe, Si, Zn, Ca, Mg, and Ba at p < 0...
April 25, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28428123/transvaginal-ultrasound-guided-embryo-transfer-in-ivf
#5
L Larue, G Keromnes, A Massari, C Roche, J Moulin, H Gronier, D Bouret, N G Cassuto, J P Ayel
OBJECTIVES: To determine whether transvaginal ultrasound-guided embryo transfer is a technique that can be used routinely, whether it improves IVF outcomes and whether it makes difficult transfers easier and more successful. MATERIAL AND METHOD: Non-randomized retrospective study conducted between 2012 and 2016 in the fertility center of the Diaconesses-Croix St-Simon hospital group. The outcomes of 3910 transfers, performed by 5 senior operators, under transabdominal ultrasound guidance are compared with those of 800 transfers, performed by 1 senior operator under transvaginal ultrasound guidance...
April 17, 2017: J Gynecol Obstet Hum Reprod
https://www.readbyqxmd.com/read/28360822/impact-of-blood-hypercoagulability-on-in-vitro-fertilization-outcomes-a-prospective-longitudinal-observational-study
#6
Grigoris T Gerotziafas, Patrick Van Dreden, Emmanuelle Mathieu d'Argent, Eleftheria Lefkou, Matthieu Grusse, Marjorie Comtet, Rabiatou Sangare, Hela Ketatni, Annette K Larsen, Ismail Elalamy
BACKGROUND: Blood coagulation plays a crucial role in the blastocyst implantation process and its alteration may be related to in vitro fertilization (IVF) failure. We conducted a prospective observational longitudinal study in women eligible for IVF to explore the association between alterations of coagulation with the IVF outcome and to identify the biomarkers of hypercoagulability which are related with this outcome. METHODS: Thirty-eight women eligible for IVF (IVF-group) and 30 healthy, age-matched women (control group) were included...
2017: Thrombosis Journal
https://www.readbyqxmd.com/read/28142289/time-lapse-imaging-is-it-time-to-incorporate-this-technology-into-routine-clinical-practice
#7
Priya Bhide, Abha Maheshwari, Rachel Cutting, Susan Seenan, Anita Patel, Khalid Khan, Roy Homburg
Time-lapse imaging (TLI) systems for embryo incubation, assessment and selection are a novel technology available to in vitro fertilization (IVF) clinics. However, there is uncertainty about their clinical and cost-effectiveness and insufficient good quality evidence to warrant their routine use. Despite this, enthusiastic commercial marketing and slipping clinical equipoise have led to the widespread hasty introduction of this technology into practice, often at a considerable expense to the patient. We have reviewed the published literature and aim to summarize the strengths, weaknesses, opportunities and threats of these systems...
February 1, 2017: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/28125970/the-use-of-the-mhealth-program-smarter-pregnancy-in-preconception-care-rationale-study-design-and-data-collection-of-a-randomized-controlled-trial
#8
Matthijs R van Dijk, Elsje C Oostingh, Maria P H Koster, Sten P Willemsen, Joop S E Laven, Régine P M Steegers-Theunissen
BACKGROUND: Unhealthy nutrition and lifestyle contribute to the worldwide rising prevalence of non-communicable diseases. This also accounts for the reproductive population, in which unhealthy behavior affects fertility and pregnancy outcome. Maternal smoking, alcohol consumption and inadequate folic acid supplement use are strongly associated with fetal complications as small for gestational age, premature birth and congenital malformations. In the Netherlands 83% of the perinatal mortality rate is due to these complications and is relatively high compared to other European countries...
January 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28029396/standards-of-care-in-infertility-in-europe
#9
REVIEW
Christina I Messini, Alexandros Daponte, George Anifandis, Tahir Mahmood, Ioannis E Messinis
Evidence-based medicine is the principal approach to medical practice. There are several debatable issues in infertility, which require clarification. Over the past 20 years, reliable methodology has been developed for the management of infertile couples. This includes high quality diagnostic and therapeutic procedures, which are applied in highly specialised infertility centres. The European Board and College of Obstetrics and Gynaecology (EBCOG) has published Standards of Care for Women's Health in Europe, which should be the cornerstone for the clinicians and service providers in the European Union to establish common protocols within their centres...
October 20, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28003868/outcome-of-one-hundred-consecutive-icsi-attempts-using-patient-operated-home-sonography-for-monitoring-follicular-growth
#10
J Gerris, F Vandekerckhove, P De Sutter
OBJECTIVE: cohort study describing clinical and laboratory outcomes in ICSI patients using self-operated endovaginal tele-monitoring (SOET). SETTING: University department of reproductive medicine. PATIENTS: 78 patients undergoing 100 consecutive ICSI attempts. INTERVENTIONS: patients' recorded vaginal sonograms and sent recordings using the cloud based Sonaura device to the care provider who procured responses, avoiding hospital visits...
September 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/28002529/delayed-interval-delivery-in-twin-pregnancy-case-reports
#11
Constantin Cristian Văduva, Carmen Constantinescu, Mihaela Ţenovici, Alice Roxana Văduva, Mihaela Niculescu, Damian DiŢescu, Cristina CrenguŢa Albu, Dinu Florin Albu
The implementation of assisted reproduction has increased the incidence of multiple pregnancies. Prenatal death of one fetus in the second trimester of twin pregnancy confronts the obstetrician with a difficult problem with regard to the management of pregnancy. The scarcity of the condition and the absence of the large-scale studies make it difficult to advise the parents on the prognosis and optimal management. The unavoidable birth or death of one premature neonate has led to the aim of delayed interval delivery for the other twin...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27746110/a-direct-healthcare-cost-analysis-of-the-cryopreserved-versus-fresh-transfer-policy-at-the-blastocyst-stage
#12
Enrico Papaleo, Luca Pagliardini, Valeria Stella Vanni, Diana Delprato, Patrizia Rubino, Massimo Candiani, Paola Viganò
A cost analysis covering direct healthcare costs relating to IVF freeze-all policy was conducted. Normal- and high- responder patients treated with a freeze-all policy (n = 63) compared with fresh transfer IVF (n = 189) matched by age, body mass index, duration and cause of infertility, predictive factors for IVF (number of oocytes used for fertilization) and study period, according to a 1:3 ratio were included. Total costs per patient (€6952 versus €6863) and mean costs per live birth were similar between the freeze-all strategy (€13,101, 95% CI 10,686 to 17,041) and fresh transfer IVF (€15,279, 95% CI 13,212 to 18,030)...
January 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27645282/how-much-have-we-learned-from-time-lapse-in-clinical-ivf
#13
D Castelló, Y Motato, N Basile, J Remohí, M Espejo-Catena, M Meseguer
Can the time-lapse system (TLS) identify the best embryo for transfer? Although there are several studies that support this hypothesis, more research is required to improve the quality of the current evidence and also to assess live birth rate, miscarriage, stillbirth or clinical pregnancy in order to choose between a TLS or conventional incubation. In addition, although some authors report on effectiveness and safety in the use of TLS monitoring of embryo development in vitro, other authors that have not found relevant differences between the two systems for the culture and subsequence embryo selection...
October 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27619774/embryo-selection-using-time-lapse-analysis-early-embryo-viability-assessment-in-conjunction-with-standard-morphology-a-prospective-two-center-pilot-study
#14
Dorit C Kieslinger, Stefanie De Gheselle, Cornelis B Lambalk, Petra De Sutter, E Hanna Kostelijk, Jos W R Twisk, Joukje van Rijswijk, Etienne Van den Abbeel, Carlijn G Vergouw
STUDY QUESTION: Does prospective embryo selection using the results from the Eava Test (Early Embryo Viability Assessment) in combination with standard morphology increase the pregnancy rate of IVF and ICSI patients compared to embryo selection based on morphology only? SUMMARY ANSWER: Embryo selection using the Eeva Test plus standard morphology on Day 3 results in comparable pregnancy rates as conventional morphological embryo selection. WHAT IS KNOWN ALREADY: Time-lapse monitoring of embryo development may represent a superior way to culture and select embryos in vitro...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27609982/development-of-a-new-clinically-applicable-device-for-embryo-evaluation-which-measures-embryo-oxygen-consumption
#15
Hiroki Kurosawa, Hiroki Utsunomiya, Naomi Shiga, Aiko Takahashi, Motomasa Ihara, Masumi Ishibashi, Mitsuo Nishimoto, Zen Watanabe, Hiroyuki Abe, Jin Kumagai, Yukihiro Terada, Hideki Igarashi, Toshifumi Takahashi, Atsushi Fukui, Ryota Suganuma, Masahito Tachibana, Nobuo Yaegashi
STUDY QUESTION: Does a new system-the chip-sensing embryo respiration monitoring system (CERMs)-enable evaluation of embryo viability for potential application in a clinical IVF setting? SUMMARY ANSWER: The system enabled the oxygen consumption rate of spheroids, bovine embryos and frozen-thawed human embryos to be measured, and this rate corresponded to the developmental potential of embryos. WHAT IS ALREADY KNOWN: To date, no reliable and clinically suitable objective evaluation methods for embryos are available, which circumvent the differences in inter-observer subjective view...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27591227/correlation-between-aneuploidy-standard-morphology-evaluation-and-morphokinetic-development-in-1730-biopsied-blastocysts-a-consecutive-case-series-study
#16
Maria Giulia Minasi, Alessandro Colasante, Teresa Riccio, Alessandra Ruberti, Valentina Casciani, Filomena Scarselli, Francesca Spinella, Francesco Fiorentino, Maria Teresa Varricchio, Ermanno Greco
STUDY QUESTION: Are there correlations among human blastocyst ploidy status, standard morphology evaluation and time-lapse kinetics? SUMMARY ANSWER: Correlations were observed, in that euploid human blastocysts showed a higher percentage with top quality inner cell mass (ICM) and trophectoderm (TE), higher expansion grades and shorter time to start of blastulation, expansion and hatching, compared to aneuploid ones. WHAT IS KNOWN ALREADY: Embryo quality has always been considered an important predictor of successful implantation and pregnancy...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27530063/automatic-time-lapse-instrument-is-superior-to-single-point-morphology-observation-for-selecting-viable-embryos-retrospective-study-in-oocyte-donation
#17
Belén Aparicio-Ruiz, Natalia Basile, Sonia Pérez Albalá, Fernando Bronet, José Remohí, Marcos Meseguer
OBJECTIVE: To correlate the different categories provided by a commercial diagnostic test with blastocyst formation, quality, implantation potential, and ongoing pregnancy (OPR) for the purpose of validating the automatic annotations and the classification algorithm. DESIGN: Observational, retrospective, multicenter cohort study. SETTING: University-affiliated private IVF center. PATIENT(S): A total of 3,002 embryos, including 521 transferred embryos with known implantation, from 626 IVF cycles that were incubated in a conventional incubator and monitored with an automatic time-lapse test...
November 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27511809/the-management-of-anovulatory-infertility-in-women-with-polycystic-ovary-syndrome-an-analysis-of-the-evidence-to-support-the-development-of-global-who-guidance
#18
REVIEW
Adam H Balen, Lara C Morley, Marie Misso, Stephen Franks, Richard S Legro, Chandrika N Wijeyaratne, Elisabet Stener-Victorin, Bart C J M Fauser, Robert J Norman, Helena Teede
BACKGROUND: Here we describe the consensus guideline methodology, summarise the evidence-based recommendations we provided to the World Health Organisation (WHO) for their consideration in the development of global guidance and present a narrative review on the management of anovulatory infertility in women with polycystic ovary syndrome (PCOS). OBJECTIVE AND RATIONALE: The aim of this paper was to present an evidence base for the management of anovulatory PCOS...
November 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27496943/assisted-reproductive-technology-in-europe-2012-results-generated-from-european-registers-by-eshre
#19
C Calhaz-Jorge, C de Geyter, M S Kupka, J de Mouzon, K Erb, E Mocanu, T Motrenko, G Scaravelli, C Wyns, V Goossens
STUDY QUESTION: The 16th European IVF-monitoring (EIM) report presents the data of the treatments involving assisted reproductive technology (ART) and intrauterine insemination (IUI) initiated in Europe during 2012: are there any changes compared with previous years? SUMMARY ANSWER: Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year, the pregnancy rates (PRs) in 2012 remained stable compared with those reported in 2011, and the number of transfers with multiple embryos (3+) and the multiple delivery rates were lower than ever before...
August 2016: Human Reproduction
https://www.readbyqxmd.com/read/27203090/cost-effectiveness-of-the-freeze-all-policy
#20
Matheus Roque, Marcello Valle, Fernando Guimarães, Marcos Sampaio, Selmo Geber
OBJECTIVE: To evaluate the cost-effectiveness of freeze-all cycles when compared to fresh embryo transfer. METHODS: This was an observational study with a cost-effectiveness analysis. The analysis consisted of 530 intracytoplasmic sperm injection (ICSI) cycles in a private center in Brazil between January 2012 and December 2013. A total of 530 intracytoplasmic sperm injection (ICSI) cycles - 351 fresh embryo transfers and 179 freeze-all cycles - with a gonadotropin-releasing hormone (GnRH) antagonist protocol and day 3 embryo transfers...
2015: JBRA Assisted Reproduction
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