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https://www.readbyqxmd.com/read/27746110/a-direct-healthcare-cost-analysis-of-the-cryopreserved-versus-fresh-transfer-policy-at-the-blastocyst-stage
#1
Enrico Papaleo, Luca Pagliardini, Valeria Stella Vanni, Diana Delprato, Patrizia Rubino, Massimo Candiani, Paola Viganò
A cost analysis covering direct healthcare costs relating to IVF freeze-all policy was conducted. Normal- and high- responder patients treated with a freeze-all policy (n = 63) compared with fresh transfer IVF (n = 189) matched by age, body mass index, duration and cause of infertility, predictive factors for IVF (number of oocytes used for fertilization) and study period, according to a 1:3 ratio were included. Total costs per patient (€6952 versus €6863) and mean costs per live birth were similar between the freeze-all strategy (€13,101, 95% CI 10,686 to 17,041) and fresh transfer IVF (€15,279, 95% CI 13,212 to 18,030)...
October 3, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27645282/how-much-have-we-learned-from-time-lapse-in-clinical-ivf
#2
D Castelló, Y Motato, N Basile, J Remohí, M Espejo-Catena, M Meseguer
Can the time-lapse system (TLS) identify the best embryo for transfer? Although there are several studies that support this hypothesis, more research is required to improve the quality of the current evidence and also to assess live birth rate, miscarriage, stillbirth or clinical pregnancy in order to choose between a TLS or conventional incubation. In addition, although some authors report on effectiveness and safety in the use of TLS monitoring of embryo development in vitro, other authors that have not found relevant differences between the two systems for the culture and subsequence embryo selection...
October 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27619774/embryo-selection-using-time-lapse-analysis-early-embryo-viability-assessment-in-conjunction-with-standard-morphology-a-prospective-two-center-pilot-study
#3
Dorit C Kieslinger, Stefanie De Gheselle, Cornelis B Lambalk, Petra De Sutter, E Hanna Kostelijk, Jos W R Twisk, Joukje van Rijswijk, Etienne Van den Abbeel, Carlijn G Vergouw
STUDY QUESTION: Does prospective embryo selection using the results from the Eava Test (Early Embryo Viability Assessment) in combination with standard morphology increase the pregnancy rate of IVF and ICSI patients compared to embryo selection based on morphology only? SUMMARY ANSWER: Embryo selection using the Eeva Test plus standard morphology on Day 3 results in comparable pregnancy rates as conventional morphological embryo selection. WHAT IS KNOWN ALREADY: Time-lapse monitoring of embryo development may represent a superior way to culture and select embryos in vitro...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27609982/development-of-a-new-clinically-applicable-device-for-embryo-evaluation-which-measures-embryo-oxygen-consumption
#4
Hiroki Kurosawa, Hiroki Utsunomiya, Naomi Shiga, Aiko Takahashi, Motomasa Ihara, Masumi Ishibashi, Mitsuo Nishimoto, Zen Watanabe, Hiroyuki Abe, Jin Kumagai, Yukihiro Terada, Hideki Igarashi, Toshifumi Takahashi, Atsushi Fukui, Ryota Suganuma, Masahito Tachibana, Nobuo Yaegashi
STUDY QUESTION: Does a new system-the chip-sensing embryo respiration monitoring system (CERMs)-enable evaluation of embryo viability for potential application in a clinical IVF setting? SUMMARY ANSWER: The system enabled the oxygen consumption rate of spheroids, bovine embryos and frozen-thawed human embryos to be measured, and this rate corresponded to the developmental potential of embryos. WHAT IS ALREADY KNOWN: To date, no reliable and clinically suitable objective evaluation methods for embryos are available, which circumvent the differences in inter-observer subjective view...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27591227/correlation-between-aneuploidy-standard-morphology-evaluation-and-morphokinetic-development-in-1730-biopsied-blastocysts-a-consecutive-case-series-study
#5
Maria Giulia Minasi, Alessandro Colasante, Teresa Riccio, Alessandra Ruberti, Valentina Casciani, Filomena Scarselli, Francesca Spinella, Francesco Fiorentino, Maria Teresa Varricchio, Ermanno Greco
STUDY QUESTION: Are there correlations among human blastocyst ploidy status, standard morphology evaluation and time-lapse kinetics? SUMMARY ANSWER: Correlations were observed, in that euploid human blastocysts showed a higher percentage with top quality inner cell mass (ICM) and trophectoderm (TE), higher expansion grades and shorter time to start of blastulation, expansion and hatching, compared to aneuploid ones. WHAT IS KNOWN ALREADY: Embryo quality has always been considered an important predictor of successful implantation and pregnancy...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27530063/automatic-time-lapse-instrument-is-superior-to-single-point-morphology-observation-for-selecting-viable-embryos-retrospective-study-in-oocyte-donation
#6
Belén Aparicio-Ruiz, Natalia Basile, Sonia Pérez Albalá, Fernando Bronet, José Remohí, Marcos Meseguer
OBJECTIVE: To correlate the different categories provided by a commercial diagnostic test with blastocyst formation, quality, implantation potential, and ongoing pregnancy (OPR) for the purpose of validating the automatic annotations and the classification algorithm. DESIGN: Observational, retrospective, multicenter cohort study. SETTING: University-affiliated private IVF center. PATIENT(S): A total of 3,002 embryos, including 521 transferred embryos with known implantation, from 626 IVF cycles that were incubated in a conventional incubator and monitored with an automatic time-lapse test...
August 13, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27511809/the-management-of-anovulatory-infertility-in-women-with-polycystic-ovary-syndrome-an-analysis-of-the-evidence-to-support-the-development-of-global-who-guidance
#7
REVIEW
Adam H Balen, Lara C Morley, Marie Misso, Stephen Franks, Richard S Legro, Chandrika N Wijeyaratne, Elisabet Stener-Victorin, Bart C J M Fauser, Robert J Norman, Helena Teede
BACKGROUND: Here we describe the consensus guideline methodology, summarise the evidence-based recommendations we provided to the World Health Organisation (WHO) for their consideration in the development of global guidance and present a narrative review on the management of anovulatory infertility in women with polycystic ovary syndrome (PCOS). OBJECTIVE AND RATIONALE: The aim of this paper was to present an evidence base for the management of anovulatory PCOS...
November 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27496943/assisted-reproductive-technology-in-europe-2012-results-generated-from-european-registers-by-eshre
#8
C Calhaz-Jorge, C de Geyter, M S Kupka, J de Mouzon, K Erb, E Mocanu, T Motrenko, G Scaravelli, C Wyns, V Goossens
STUDY QUESTION: The 16th European IVF-monitoring (EIM) report presents the data of the treatments involving assisted reproductive technology (ART) and intrauterine insemination (IUI) initiated in Europe during 2012: are there any changes compared with previous years? SUMMARY ANSWER: Despite some fluctuations in the number of countries reporting data, the overall number of ART cycles has continued to increase year by year, the pregnancy rates (PRs) in 2012 remained stable compared with those reported in 2011, and the number of transfers with multiple embryos (3+) and the multiple delivery rates were lower than ever before...
August 2016: Human Reproduction
https://www.readbyqxmd.com/read/27203090/cost-effectiveness-of-the-freeze-all-policy
#9
Matheus Roque, Marcello Valle, Fernando Guimarães, Marcos Sampaio, Selmo Geber
OBJECTIVE: To evaluate the cost-effectiveness of freeze-all cycles when compared to fresh embryo transfer. METHODS: This was an observational study with a cost-effectiveness analysis. The analysis consisted of 530 intracytoplasmic sperm injection (ICSI) cycles in a private center in Brazil between January 2012 and December 2013. A total of 530 intracytoplasmic sperm injection (ICSI) cycles - 351 fresh embryo transfers and 179 freeze-all cycles - with a gonadotropin-releasing hormone (GnRH) antagonist protocol and day 3 embryo transfers...
2015: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/27181924/transplantations-of-frozen-thawed-ovarian-tissue-demonstrate-high-reproductive-performance-and-the-need-to-revise-restrictive-criteria
#10
Dror Meirow, Hila Ra'anani, Moran Shapira, Masha Brenghausen, Sanaz Derech Chaim, Sarit Aviel-Ronen, Ninette Amariglio, Eyal Schiff, Raoul Orvieto, Jehoshua Dor
OBJECTIVE: To report the single-center results of orthotopic retransplantations of cryopreserved ovarian tissue in cancer survivors and evaluate the validity of commonly accepted procedure limitations. DESIGN: Prospective cohort study. SETTING: Tertiary university-affiliated assisted reproduction technology (ART) and oncology centers. PATIENT(S): Twenty cancer survivors who underwent ovarian transplantation of frozen-thawed ovarian tissue with the aim to conceive...
August 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27163782/monitoring-neonatal-abstinence-syndrome-in-buprenorphine-exposed-in-vitro-fertilization-twins-a-case-study
#11
Laura Brandt, Patrick Swoboda, Gabriele Fischer, Annemarie Unger
BACKGROUND: Prior studies have reported on the pregnancies and outcomes of in vitro fertilization (IVF) in special subpopulations; however, there is a lack of studies on opioid-exposed IVF-conceived neonates. CASE PRESENTATION: A young adult IVF-pregnant woman was maintained on buprenorphine throughout pregnancy and received follow-up from the addiction clinic from estimated gestational week 32. She delivered healthy dichorionic twins via cesarean section at 38 weeks gestational age (buprenorphine dose at time of delivery: 16 mg)...
October 2016: Substance Abuse
https://www.readbyqxmd.com/read/27007875/is-oocyte-donation-a-risk-factor-for-preeclampsia-a-systematic-review-and-meta-analysis
#12
REVIEW
Anna Blázquez, Désirée García, Amelia Rodríguez, Rita Vassena, Francesc Figueras, Valérie Vernaeve
PURPOSE: The objective of this meta-analysis is to determine whether there is a higher incidence of preeclampsia (PE) in pregnancies achieved by oocyte donation (OD) compared with pregnancies achieved by in vitro fertilization with autologous oocytes (IVF). METHODS: A systematic review was performed to identify relevant studies published from January 1994 until April 2015 with at least an abstract in English using PubMed, ISI Web of Knowledge, and clinicaltrials...
July 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/26865544/the-presence-of-endometrioma-does-not-impair-time-lapse-morphokinetic-parameters-and-quality-of-embryos-a-study-on-sibling-oocytes
#13
Cem Demirel, Ercan Bastu, Serkan Aydogdu, Ersan Donmez, Hasan Benli, Gulsum Tuysuz, Gulsah Keskin, Faruk Buyru
OBJECTIVE: To see whether the oocytes retrieved from an ovary with an endometrioma would develop into embryos with aberrant timings of cleavage as assessed using time-lapse monitoring (TLM) and poorer morphologic quality compared with sibling oocytes from the contralateral ovary with no endometrioma in the same patient after intracytoplasmic sperm injection. METHODS: This was an observational prospective study at an in vitro fertilization (IVF) center of a private hospital...
August 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/26843394/do-morphokinetic-data-sets-inform-pregnancy-potential
#14
Robert Milewski, Anna Justyna Milewska, Agnieszka Kuczyńska, Bożena Stankiewicz, Waldemar Kuczyński
PURPOSE: The aim of this study was to create a model to predict the implantation of transferred embryos based on information contained in the morphokinetic parameters of time-lapse monitoring. METHODS: An analysis of time-lapse recordings of 410 embryos transferred in 343 cycles of in vitro fertilization (IVF) treatment was performed. The study was conducted between June 2012 and November 2014. For each embryo, the following data were collected: the duration of time from the intracytoplasmic sperm injection (ICSI) procedure to further division for two, three, four, and five blastomeres, time intervals between successive divisions, and the level of fragmentation assessed in successive time-points...
March 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/26843390/comparing-blastocyst-quality-and-live-birth-rates-of-intravaginal-culture-using-invocell%C3%A2-to-traditional-in-vitro-incubation-in-a-randomized-open-label-prospective-controlled-trial
#15
Kevin J Doody, E Jason Broome, Kathleen M Doody
PURPOSE: The purpose of this study is to to compare the efficacy of intravaginal culture (IVC) of embryos in INVOcell™ (INVO Bioscience, MA, USA) to traditional in vitro fertilization (IVF) incubators in a laboratory setting using a mild pre-determined stimulation regimen based solely on anti-mullerian hormone (AMH) and body weight with minimal ultrasound monitoring. The primary endpoint examined was total quality blastocysts expressed as a percentage of total oocytes placed in incubation...
April 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/26740578/assisted-reproductive-technology-in-europe-2011-results-generated-from-european-registers-by-eshre
#16
M S Kupka, T D'Hooghe, A P Ferraretti, J de Mouzon, K Erb, J A Castilla, C Calhaz-Jorge, Ch De Geyter, V Goossens
STUDY QUESTION: The 15th European IVF-monitoring (EIM) report presents the results of treatments involving assisted reproductive technology (ART) initiated in Europe during 2011: are there any changes in the trends compared with previous years? SUMMARY ANSWER: Despite some fluctuations in the number of countries reporting data, while the overall number of ART cycles has continued to increase year by year, the pregnancy rates in 2011 decreased slightly to those reported in 2010, and the number of transfers with multiple embryos (3+) and the multiple delivery rates declined...
February 2016: Human Reproduction
https://www.readbyqxmd.com/read/26732620/a-novel-antioxidant-formulation-designed-to-treat-male-infertility-associated-with-oxidative-stress-promising-preclinical-evidence-from-animal-models
#17
P Gharagozloo, A Gutiérrez-Adán, A Champroux, A Noblanc, A Kocer, A Calle, S Pérez-Cerezales, E Pericuesta, A Polhemus, A Moazamian, J R Drevet, R J Aitken
STUDY QUESTION: Does a novel antioxidant formulation designed to restore redox balance within the male reproductive tract, reduce sperm DNA damage and increase pregnancy rates in mouse models of sperm oxidative stress? SUMMARY ANSWER: Oral administration of a novel antioxidant formulation significantly reduced sperm DNA damage in glutathione peroxidase 5 (GPX5), knockout mice and restored pregnancy rates to near-normal levels in mice subjected to scrotal heat stress...
February 2016: Human Reproduction
https://www.readbyqxmd.com/read/26714912/-embryo-selection-in-ivf-icsi-cycles-using-time-lapse-microscopy-and-the-clinical-outcomes
#18
Minghao Chen, Jun Huang, Ying Zhong, Song Quan
OBJECTIVE: To compare the clinical outcomes of embryos selected using time-lapse microscopy and traditional morphological method in IVF/ICSI cycles and evaluate the clinical value of time-lapse microscopy in early embryo monitoring and selection. METHODS: e retrospectively analyzed the clinical data of 139 IVF/ICSI cycles with embryo selection based on time-lapse monitoring (TLM group, n=68) and traditional morphological method (control group, n=71). The βHCG-positive rate, clinical pregnancy rate and embryo implantation rate were compared between the 2 groups...
December 2015: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/26677580/inhibin-a-and-b-levels-in-serum-and-follicular-fluids-of-women-with-various-reproductive-failures-undergoing-in-vitro-fertilization
#19
COMPARATIVE STUDY
Katarína Babćová, Zdenk Ulčová-Gallová, David Rumpík, Zdenka Mičanová, Katarína Bibková
OBJECTIVE: Ovarian inhibins (INH) are hormones participating in the regulation of gametogenesis. We monitored inhibin A and B levels in serum (S) and follicular fluids (FF), depending on the type of fertility failure and treatment outcome. MATERIAL AND METHODS: We examined INHA and B levels in S and FF of 72 women undergoing ovarian stimulation for in vitro fertilization, including embryo transfer We took serum samples at the time of egg collection (S1), embryo transfer (S2), and diagnostics of early pregnancy (S3)...
October 2015: Ginekologia Polska
https://www.readbyqxmd.com/read/26667662/ovarian-stimulation-with-human-and-recombinant-gonadotropin-comparison-of-in-vitro-fertilization-efficiency-with-use-of-time-lapse-monitoring
#20
COMPARATIVE STUDY
Artur Wdowiak, Iwona Bojar
BACKGROUND: Achieving pregnancy by in vitro fertilization (IVF) treatment depends on many factors, including the ovaries' capacity and the efficiency of ovarian stimulation. The aim of this study was to assess the influence of ovarian stimulation with human and recombinant gonadotropin, as well as specific hormonal parameters, on the effectiveness of IVF and the dynamics of embryonic development. METHODS: The study involved 221 women aged 25-35 years in whom intracytoplasmic sperm injection was performed...
2015: Reproductive Health
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