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FoxO1 AND Vitamin D

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https://www.readbyqxmd.com/read/26462119/foxo1-mediates-vitamin-d-deficiency-induced-insulin-resistance-in-skeletal-muscle
#1
Songcang Chen, S Armando Villalta, Devendra K Agrawal
Prospective epidemiological studies have consistently shown a relationship between vitamin D deficiency, insulin resistance, and type 2 diabetes mellitus (DM2). This is supported by recent trials showing that vitamin D supplementation in prediabetic or insulin-resistant patients with inadequate vitamin D levels improves insulin sensitivity. However, the molecular mechanisms underlying vitamin D deficiency-induced insulin resistance and DM2 remain unknown. Skeletal muscle insulin resistance is a primary defect in the majority of patients with DM2...
March 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/23098692/influence-of-vitamin-d-on-cisplatin-sensitivity-in-testicular-germ-cell-cancer-derived-cell-lines-and-in-a-ntera2-xenograft-model
#2
Anne Jørgensen, Martin Blomberg Jensen, John Erik Nielsen, Anders Juul, Ewa Rajpert-De Meyts
The active form of vitamin D, 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has anti-proliferative, pro-apoptotic, and pro-differentiating effects in somatic cancer cells in vitro and in vivo. 1,25(OH)2D3 also augments the anti-tumor effects of several chemotherapeutic agents, including cisplatin, which may have clinical relevance. Given the pro-differentiation effect of vitamin D recently demonstrated in testicular germ cell tumors (TGCTs), we hypothesized that 1,25(OH)2D3 could be a beneficial adjunctive to existing chemotherapy regime used to treat these tumors...
July 2013: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/22989484/1-25-dihydroxyvitamin-d3-and-the-aging-related-forkhead-box-o-and-sestrin-proteins-in-osteoblasts
#3
Guy Eelen, Lieve Verlinden, Mark B Meyer, Rik Gijsbers, J Wesley Pike, Roger Bouillon, Annemieke Verstuyf
Forkhead Box O (FoxO) transcription factors and Sestrins (SESN) are highly conserved and related stress-responsive proteins that protect the organism against age-related pathologies. For FoxOs, growing evidence shows a crucial role in osteoblast function. Here we investigated the role of different FoxO and SESN isoforms in 1,25(OH)2D3-treated MC3T3-E1 osteoblasts. 1,25(OH)2D3 rapidly and strongly induced the expression of SESN1 and FoxO3a but down-regulated the expression of SESN3 and FoxO1. SESN2 and FoxO4 levels were hardly affected by 1,25(OH)2D3...
July 2013: Journal of Steroid Biochemistry and Molecular Biology
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