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https://www.readbyqxmd.com/read/27925292/cognitive-impairment-in-parkinson-s-disease-impact-on-quality-of-life-of-carers
#1
R A Lawson, A J Yarnall, F Johnston, G W Duncan, T K Khoo, D Collerton, J P Taylor, D J Burn
BACKGROUND: The quality of life (QoL) of informal caregivers of people with Parkinson's disease (PD) (PwP) can be affected by the caring role. Because of cognitive symptoms and diminished activities of daily living, in addition to the management of motor symptoms, carers of PwP and cognitive impairment may experience increased levels of burden and poorer QoL compared with carers of PwP without cognitive impairment. This study aimed to investigate the impact of cognitive impairment in PD upon QoL of carers...
December 7, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27923814/mir-483-targeting-of-ctgf-suppresses-endothelial-to-mesenchymal-transition-therapeutic-implications-in-kawasaki-disease
#2
Ming He, Zhen Chen, Marcy Martin, Jin Zhang, Panjamaporn Sangwung, Brian Woo, Adriana Tremoulet, Chisato Shimizu, Mukesh K Jain, Jane C Burns, John Shyy
RATIONALE: Endothelial-to-mesenchymal transition (EndoMT) is implicated in myofibroblast-like cell-mediated damage to the coronary arterial wall in acute Kawasaki disease (KD) patients, as evidenced by positive staining for connective tissue growth factor (CTGF) and EndoMT markers in KD autopsy tissues. However, little is known about the molecular basis of EndoMT involved in KD. OBJECTIVE: We investigated the microRNA (miRNA) regulation of CTGF and the consequent EndoMT in KD pathogenesis...
December 6, 2016: Circulation Research
https://www.readbyqxmd.com/read/27920829/clinical-and-genetic-features-of-australian-families-with-long-qt-syndrome-a-registry-based-study
#3
Charlotte Burns, Jodie Ingles, Andrew M Davis, Vanessa Connell, Belinda Gray, Lauren Hunt, Julie McGaughran, Christopher Semsarian
BACKGROUND: Familial long QT syndrome (LQTS) is a primary arrhythmogenic disorder caused by mutations in ion channel genes. The phenotype ranges from asymptomatic individuals to sudden cardiac arrest and death. LQTS is a rare but significant health problem for which global data should exist. This study sought to provide the first clinical and genetic description of Australian families with LQTS. METHODS: We performed a cross-sectional study to evaluate clinical and genetic features of families with LQTS...
December 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27919663/efficacy-of-low-level-laser-therapy-in-the-treatment-of-burning-mouth-syndrome-a-systematic-review
#4
REVIEW
Sadeq Ali Al-Maweri, Fawad Javed, Butchibabu Kalakonda, Nader A AlAizari, Walid Al-Soneidar, Ameen Al-Akwa
BACKGROUND: Burning mouth syndrome (BMS) is a chronic pain condition with indefinite cure, predominantly affecting post-menopausal women. The aim of this study was to systematically review the efficacy of low level laser therapy in the treatment of burning mouth syndrome (BMS). METHODS: PubMed, Embase and Scopus were searched from date of inception till and including October 2016 using various combinations of the following keywords: burning mouth syndrome, BMS, stomatodynia, laser therapy, laser treatment and phototherapy...
December 2, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27917800/laparoscopic-nissen-fundoplication-with-mesh-hiatoplasty-single-center-experience-and-early-term-results
#5
Mehmet Tolga Kafadar, Metin Yalaza, Ahmet Türkan, Önder Sürgit, Gürkan Değirmencioğlu, Işilay Nadir
PURPOSE: In this study we report early-term results of laparoscopic Nissen fundoplication with mesh hiatoplasty that we perform to treat gastroesophageal reflux disease. METHODS: We retrospectively reviewed the medical records of 68 patients who underwent laparoscopic Nissen fundoplication with mesh hiatoplasty at our clinic. Thirty-six (53%) patients were male and 32 (47%) were female. The mean age of the study population was 46.1 (25-72) years. All patients underwent endoscopy, esophagus pH metry and manometry before the operation...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27903244/cryopreservation-of-dermal-fibroblasts-and-keratinocytes-in-hydroxyethyl-starch-based-cryoprotectants
#6
Yahaira Naaldijk, Adiv A Johnson, Annett Friedrich-Stöckigt, Alexandra Stolzing
BACKGROUND: Preservation of human skin fibroblasts and keratinocytes is essential for the creation of skin tissue banks. For successful cryopreservation of cells, selection of an appropriate cryoprotectant agent (CPA) is imperative. The aim of this study was to identify CPAs that minimize toxic effects and allow for the preservation of human fibroblasts and keratinocytes in suspension and in monolayers. RESULTS: We cryopreserved human fibroblasts and keratinocytes with different CPAs and compared them to fresh, unfrozen cells...
December 1, 2016: BMC Biotechnology
https://www.readbyqxmd.com/read/27900750/-the-management-of-itching-in-burn-patients-during-the-rehabilitation-stage
#7
Shu-Fen Lo, Li-Jung Chang, Ting-Yuan Shiue, Ching-Yi Pan, Hui-Chuan Wu
Pruritus, a distressing symptom that affects burn patients, not only interferes with activities of daily living but also causes disturbed sleep, which has been associated with anxiety, depression, and other types of negative moods. Furthermore, the uncontrolled scratching that often accompanies pruritus causes tissue damage and may damage or destroy the skin graft. In this paper, the authors first describe the definition and mechanism of pruritus and next use itching-assessment tools to identify the triggering factors...
December 2016: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/27900250/effect-of-tens-on-stimulation-of-saliva-in-postmenopausal-women-with-or-without-oral-dryness-an-interventional-study
#8
Aravinda Konidena, Dheeraj Sharma, Gagan Puri, Avani Dixit, Deepa Jatti, Rajesh Gupta
BACKGROUND: Decreased estrogen levels in postmenopausal women may cause an increase in oral symptoms including dry mouth, burning sensation of the mouth, and taste alterations. Management of salivary gland hypofunction by various modalities had been tried with variable results and associated side effects or discomfort. AIM: To evaluate the effects of transcutaneous electric nerve stimulation (TENS) on whole salivary flow rate in postmenopausal females with and without oral dryness...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27898491/psychosocial-factors-predict-opioid-analgesia-via-endogenous-opioid-function
#9
John W Burns, Stephen Bruehl, Christopher R France, Erik Schuster, Daria Orlowska, Asokumar Buvanendran, Melissa Chont, Rajnish K Gupta
Use of opioid analgesics for management of chronic nonmalignant pain has become common, yet there are presently no well-validated predictors of optimal opioid analgesic efficacy. We examined whether psychosocial factors (e.g. depressive symptoms) predicted changes in spontaneous low back pain following administration of opioid analgesics, and whether endogenous opioid (EO) function mediated these relationships. Participants with chronic low back pain but who were not chronic opioid users (N = 89) underwent assessment of low back pain intensity pre- and post-drug in three (counterbalanced) conditions: 1) placebo, 2) intravenous naloxone, 3) intravenous morphine...
November 18, 2016: Pain
https://www.readbyqxmd.com/read/27896190/the-use-of-locally-applied-vibration-to-minimize-pain-during-fractional-co2-laser-therapy-in-living-liver-donor-scar-management
#10
Sinyoung Song, Dong Hoon Choi, Tae Suk Oh
BACKGROUND: Fractional CO2 laser is an effective treatment for scars, but most patients complain about sharp burning pain, even after the application of lidocaine ointment. This study analyzed the impact of a vibrating device to nonpharmacologically reduce the acute pain of laser treatment, in accordance with the gate control theory of pain management. METHODS: This is a prospective study performed from May 2013 through March 2014. Fifty-three patients (mean age, 26...
November 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/27893579/the-psychological-impact-of-first-burn-camp-in-nicaragua
#11
Lisa L Tropez-Arceneaux, Arlen Tatiana Castillo Alaniz, Ivette Lucia Icaza, Eevelyn Alejandra Murillo
Asociacion Pro-Ninos Quemados de Nicaragua (APROQUEN) is a comprehensive burn center that provides a holistic and integrated approach to treating burns. APROQUEN has set the standards internationally with acute treatment for burns, intensive care, reconstructive surgeries, nutritional care, rehabilitation, occupational therapy, and psychological treatment. APROQUEN is excelling within Central and South America with life-saving techniques and quality of care. It is imperative that burn centers in Central America recognize that the treatment of a child with a burn injury surpasses physical care to include psychological treatment for the complete well-being of the child...
November 11, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27893575/variations-in-burn-excision-and-grafting-a-survey-of-the-american-burn-association
#12
Jacqueline S Israel, David G Greenhalgh, Angela L Gibson
It is unknown whether variations in burn care affect outcomes or affect the success of emerging therapeutics. The purpose of this study was to assess burn surgeons' preferences in excision and grafting to determine if surgical technique affects outcomes. A 71-item survey evaluating skin grafting techniques was emailed to members of the American Burn Association in July and August 2015. The survey was anonymous and voluntary. Relationships between variables were evaluated using Fisher's exact test. A P-value of ≤...
November 15, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27893167/effects-of-low-level-laser-therapy-on-burning-mouth-syndrome
#13
Sara Valenzuela, Pia Lopez-Jornet
OBJECTIVES: To investigate low-level laser therapy (LLLT) applied to treat burning mouth syndrome (BMS). MATERIALS AND METHODS: This prospective. comparative. partially-blinded. single-centre. clinical trial of GaAlAs Laser. with 815 nm wavelength. included 44 BMS patients divided randomly into three groups: Group I (n=16): GaAlAs laser 815 nm wave-length. 1W output power. continuous emissions. 4 seconds .4 Joules and fluence rate is 133.3 joules/cm(2) . Group II (n=16): GaAlAs infrared laser...
November 28, 2016: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/27889388/cellular-aging-contributes-to-failure-of-cold-induced-beige-adipocyte-formation-in-old-mice-and-humans
#14
Daniel C Berry, Yuwei Jiang, Robert W Arpke, Elizabeth L Close, Aki Uchida, David Reading, Eric D Berglund, Michael Kyba, Jonathan M Graff
Cold temperatures induce progenitor cells within white adipose tissue to form beige adipocytes that burn energy and generate heat; this is a potential anti-diabesity therapy. However, the potential to form cold-induced beige adipocytes declines with age. This creates a clinical roadblock to potential therapeutic use in older individuals, who constitute a large percentage of the obesity epidemic. Here we show that aging murine and human beige progenitor cells display a cellular aging, senescence-like phenotype that accounts for their age-dependent failure...
November 21, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27878785/lesions-requiring-wound-management-in-a-central-tertiary-neonatal-intensive-care-unit
#15
Angéla Meszes, Gyula Tálosi, Krisztina Máder, Hajnalka Orvos, Lajos Kemény, Zsanett Renáta Csoma
BACKGROUND: Most of the skin disorders that occur in neonatal intensive care units are due in part to the immaturity and vulnerability of the neonatal skin. Various iatrogenic diagnostic and therapeutic procedures are also conducive to iatrogenic damage. This study was to review the neonates admitted to our neonatal intensive care unit who needed wound management, and to assess the most common skin injuries and wounds, and their aetiology. METHODS: Data were extracted from medical records of neonates who needed wound management in our Neonatal Intensive Care Unit between January 31, 2012 and January 31, 2013...
November 23, 2016: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/27867072/changes-in-electrical-dyssynchrony-by-body-surface-mapping-predict-left-ventricular-remodeling-in-cardiac-resynchronization-therapy-patients
#16
Ryan M Gage, Antonia E Curtin, Kevin V Burns, Subham Ghosh, Jeffrey M Gillberg, Alan J Bank
BACKGROUND: Electrical activation is important in CRT response. Standard ECG analysis may not accurately reflect the heterogeneity of electrical activation. OBJECTIVE: We compared changes in LV size and function following CRT to native electrical dyssynchrony and its change during pacing. METHODS: Body-surface isochronal maps utilizing 53 anterior and posterior electrodes, and 12-lead ECGs, were acquired following CRT in 66 consecutive patients...
November 17, 2016: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/27866178/low-level-laser-therapy-a-review-of-its-applications-in-the-management-of-oral-mucosal-disorders
#17
Juliana Cassol Spanemberg, Maria Antonia Zancanaro Figueiredo, Karen Cherubini, Fernanda Gonçalves Salum
Due to its analgesic, anti-inflammatory, and biostimulating effects, low-level laser therapy (LLLT) has been widely used for oral disorders, such as oral lichen planus (OLP), xerostomia, recurrent aphthous stomatitis (RAS), herpes labialis, burning mouth syndrome (BMS), and oral mucositis (OM). The research team for the present study has reviewed the literature on the subject, with an emphasis on the applicability of LLLT in general and of its various clinical protocols for the management of those oral disorders...
November 2016: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/27862103/pharmacokinetics-of-imipenem-cilastatin-burn-intensive-care-unit-patients-undergoing-high-dose-continuous-venovenous-hemofiltation
#18
Bradley A Boucher, Joanna Q Hudson, David M Hill, Joseph M Swanson, G Christopher Wood, S Casey Laizure, Angela Arnold-Ross, Zhe-Yi Hu, William L Hickerson
STUDY OBJECTIVE: High dose continuous venovenous hemofiltration (CVVH) is a continuous renal replacement therapy (CRRT) used frequently inpatients with burns. However, antibiotic dosing is based on inference from studies assessing substantially different methods of CRRT. To address this knowledge gap for imipenem/cilastatin (I-C) we evaluated the systemic and extracorporeal clearances (CL) of I-C in patients with burns undergoing high dose CVVH. DESIGN: Prospective clinical pharmacokinetic study...
November 9, 2016: Pharmacotherapy
https://www.readbyqxmd.com/read/27857653/immediate-tangential-excision-accelerates-wound-closure-but-does-not-reduce-scarring-of-mid-dermal-porcine-burns
#19
L K Macri, A J Singer, S A McClain, L Crawford, A Prasad, J Kohn, R A F Clark
Current evidence supports the use of excision to remove eschar from deep dermal and full-thickness burns. However, the role of excision of mid-dermal burns remains unclear. This study aimed to develop a porcine model that could produce reproducible middermal thermal burns that undergo tangential excision; and investigate the effects of immediate tangential excision (30 minutes postburn) on healing and scarring. An aluminum bar preheated in hot water (70°C) was applied for 20 or 30 s to produce a total of sixteen mid-dermal burns per pig on each of six pigs...
March 31, 2016: Annals of Burns and Fire Disasters
https://www.readbyqxmd.com/read/27857649/la-n%C3%A3-crolyse-%C3%A3-pidermique-toxique
#20
A Mokline, I Rahmani, L Garsallah, S Tlaili, R Hammouda, A A Messadi
Toxic epidermal necrolysis (TEN) or Lyell's syndrome is a potentially life-threatening dermatological disorder, with clinical and histological features characterized by the destruction and detachment of the skin epithelium and mucous membranes. Intensive symptomatic management is crucial: analgesia, daily dressing changes, prevention of infections and symptomatic intensive care measures (hydration, nutrition and oxygen therapy). The aim of our study is to determine epidemiological, clinical and therapeutic characteristics of patients admitted to the intensive burn care unit of Tunis over 9 years, from July 2001 to July 2009...
March 31, 2016: Annals of Burns and Fire Disasters
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