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https://www.readbyqxmd.com/read/30445620/early-surgical-management-of-thermal-airway-injury-a-case-series
#1
Asitha Jayawardena, Anne S Lowery, Christopher Wootten, Gregory R Dion, J Blair Summitt, Stuart McGrane, Alexander Gelbard
Introduction: Inhalation injury is an independent risk factor in burn mortality, imparting a 20% increased risk of death. Yet there is little information on the natural history, functional outcome, or pathophysiology of thermal injury to the laryngotracheal complex, limiting treatment progress. Methods: Case series (n=3) of significant thermal airway injury. Results: In all cases, the initial injury was far exceeded by the subsequent immune response and aggressive fibro-inflammatory healing...
November 15, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/30444149/anti-interleukin-il-5-as-a-steroid-sparing-agent-in-chronic-eosinophilic-pneumonia
#2
Edmond Sarkis, Sumit Patel, Kenneth Burns, Hanan Batarseh, M Jeffery Mador
INTRODUCTION: Anti-interleukin (IL)-5 therapy is a novel drug class clinically effective in patients with diverse eosinophil-related disorders such as allergic eosinophilic asthma, eosinophilic granulomatosis with polyangiitis (EGPA), nasal polyposis, eosinophilic COPD, and other non-pulmonary disorders such as eosinophilic esophagitis. Chronic eosinophilic pneumonia (CEP) is a steroid responsive disorder, however, relapses are common following corticosteroid tapering. CASE STUDY: We present the case of a 42-year-old woman with steroid-dependent relapsing CEP successfully treated with anti-IL-5 antibody...
November 16, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/30443955/human-neonatal-stem-cell-derived-skin-substitute-improve-healing-of-severe-burn-wounds-in-a-rat-model
#3
Ruhma Mahmood, Azra Mehmood, Mahmood S Choudhery, Sana Javaid Awan, Shaheen N Khan, Sheikh Riazuddin
Conventional approaches can repair minor skin injuries; however, severe burn injuries require innovative approaches for efficient and better wound repair. Recent studies indicate that stem-cell-based regenerative therapies can restore severe damaged skin both structurally and functionally. The current study aims to evaluate the wound healing potential of skin substitute derived from human neonatal stem cells (hNSCs) using a severe burn injury rat model. AECs (Amniotic epithelial cells) and MSCs (mesenchymal stem cells) were isolated from placenta (a source of neonatal stem cells) by explant culture method...
November 16, 2018: Cell Biology International
https://www.readbyqxmd.com/read/30443440/qrs-complex-detection-and-measurement-algorithms-for-multichannel-ecgs-in-cardiac-resynchronization-therapy-patients
#4
Antonia E Curtin, Kevin V Burns, Alan J Bank, Theoden I Netoff
We developed an automated approach for QRS complex detection and QRS duration (QRSd) measurement that can effectively analyze multichannel electrocardiograms (MECGs) acquired during abnormal conduction and pacing in heart failure and cardiac resynchronization therapy (CRT) patients to enable the use of MECGs to characterize cardiac activation in such patients. The algorithms use MECGs acquired with a custom 53-electrode investigational body surface mapping system and were validated using previously collected data from 58 CRT patients...
2018: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/30440144/-national-experts-consensus-on-application-of-silver-containing-dressings-in-wound-therapy-2018-version
#5
J P Zhang
New silver-containing dressings developed in recent years have brought new and powerful means for the prevention and treatment of wound infection, which promote development and progress of wound therapy. There are many kinds of silver-containing dressings, however, misunderstanding and even misapplication exist in how to choose and use these dressings. Based on literature evidence, we propose this national expert consensus on clinical application of silver-containing dressings, particularly in terms of kinds and mechanisms, indications, contraindications, rational selections in different wounds, and cautions in the clinical application of silver-containing dressings...
November 9, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/30431725/the-efficacy-of-low-level-laser-therapy-in-burning-mouth-syndrome-a-pilot-study
#6
Miroslav Sikora, Aleksandar Včev, Stjepan Siber, Vanja Vučićević Boras, Željko Rotim, Marko Matijević
The aim of this clinical study was to compare low-level laser therapy (LLLT) switched on and switched off in the treatment of burning mouth syndrome (BMS). BMS is a debilitating condition for patients and highly demanding for physicians, characterized by burning symptoms in the oral cavity. Despite extensive research, so far only cognitive behavioral therapy and clonazepam have been proven successful for its treatment in randomized controlled trials. Forty-four patients with BMS were randomly assigned to the study laser group (LLLT) or the sham laser group...
June 2018: Acta Clinica Croatica
https://www.readbyqxmd.com/read/30430049/medical-needling-effect-on-skin-erythema-of-hypertrophic-burn-scars
#7
Kay-Hendrik Busch, Antigona Aliu, Nicole Walezko, Matthias Aust
Background Burn scars frequently tend to have pathological discolorations, which is manifested in the development of persistent erythema. Affected people suffer from psychological and physiological issues when they are restricted or rejected in their daily life. In this context, medical needling seems to be an efficient therapy for erythematous scars with a relatively low-risk rate of postoperative complications. Study research has already shown significant improvements in the scar quality with reference to the parameters "moisture and transepidermal water loss...
September 6, 2018: Curēus
https://www.readbyqxmd.com/read/30429074/effectiveness-of-ecmo-for-burn-related-acute-respiratory-distress-syndrome
#8
R Scott Eldredge, Yan Zhai, Amalia Cochran
INTRODUCTION: Acute respiratory distress syndrome (ARDS) is a complication that affects approximately 40% of burn patients and is associated with high mortality rates. Extracorporeal membrane oxygenation (ECMO) therapy is a management option for severe refractory hypoxemic respiratory failure; however, there is little literature reporting the effectiveness of this therapy in burns. Our study objective was to review patient outcomes in burns following severe ARDS treated with ECMO. METHODS: We retrospectively reviewed all patients treated with ECMO for ARDS who received their burn care at a single regional burn center between 9/1/2006 and 8/31/2016...
November 11, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/30428877/impact-of-pharmacy-services-on-initial-clinical-outcomes-and-medication-adherence-among-veterans-with-uncontrolled-diabetes
#9
Justin D Gatwood, Marie Chisholm-Burns, Robert Davis, Fridtjof Thomas, Praveen Potukuchi, Adriana Hung, M Shawn McFarland, Csaba P Kovesdy
BACKGROUND: Diabetes remains a growing public health threat but evidence supports the role that pharmacists can play in improving diabetes medication use and outcomes. To improve the quality of care, the Veterans Health Administration has widely adopted care models that integrate clinical pharmacists, but more data are needed to interpret the impact of these services. Our objective was to assess clinical pharmacy services' impact on outcomes and oral antidiabetic medication (OAD) use among veterans with uncontrolled diabetes in the first year of therapy...
November 14, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/30419522/bio-synthesis-of-barleria-gibsoni-leaf-extract-mediated-zinc-oxide-nanoparticles-and-their-formulation-gel-for-wound-therapy-in-nursing-care-of-infants-and-children
#10
Feng Shao, AiJun Yang, Dong Mei Yu, Juan Wang, Xue Gong, Hong Xiao Tian
Bio-synthesis of nano-metal oxide particles is gaining lot of significance and recommended as promising substitute not only physical methods but also chemical methods. Here in, we demonstrate the nano-zinc oxide (nano-ZnO) particles were successfully prepared by an eco-friendly process using plant Barleria gibsoni (B. gibsoni) aqueous leaf extract. The water leaf extract of B. gibsoni responsible for not only reducing source but also protective agent. The prepared nano-ZnO particles were studied by UV-Vis diffuse reflectance (UV-DRS), Photoluminescence (PL), Fourier transform (FT-IR) infrared spectroscopy, X-ray diffraction spectroscopy (X-RD), transmission electron microscopy (TEM), thermal stability was studied by thermogravimetric and differential thermal (TG-DTA) analysis and particle size by zeta sizer, dynamic light scattering (DLS)...
October 18, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/30419303/the-impact-of-dry-eye-disease-treatment-on-patient-satisfaction-and-quality-of-life-a-review
#11
REVIEW
José A P Gomes, Ruth M Santo
Several aspects of the quality of life (QoL) and treatment satisfaction of patients with dry eye disease (DED) may be underestimated. Ocular symptoms, which are assessed by validated patient-reported questionnaires and may include stinging, burning, itchiness, grittiness, dryness and discomfort, reduce QoL by affecting daily activities and work productivity. Self-reported symptoms do not always correlate with post-treatment improvements in clinical measures such as tear film break-up time, inflammation and osmolarity...
November 9, 2018: Ocular Surface
https://www.readbyqxmd.com/read/30418163/time-to-abandon-antimicrobial-approaches-in-wound-healing-a-paradigm-shift
#12
Jeanette Sams-Dodd, Frank Sams-Dodd
Antimicrobial approaches (eg, antibiotics and antiseptics) have been used for decades in the treatment of infected wounds, ulcers, and burns. However, an increasing number of meta-analyses have raised questions regarding the therapeutic value of these approaches. Newer findings show that the body actively hosts an ecosystem of bacteria, fungi, viruses, and mites on its outer surfaces, known as the microbiome, as part of its defense against pathogens. Antimicrobials would disrupt this system and thereby work against the strategy the body has chosen...
November 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/30409227/long-term-effectiveness-of-local-bm-mscs-for-skeletal-muscle-regeneration-a-proof-of-concept-obtained-on-a-pig-model-of-severe-radiation-burn
#13
Christine Linard, Michel Brachet, Bruno L'homme, Carine Strup-Perrot, Elodie Busson, Michel Bonneau, Jean-Jacques Lataillade, Eric Bey, Marc Benderitter
BACKGROUND: Medical management of the severe musculocutaneous radiation syndrome involves surgical intervention with debridement of necrotic tissue. Even when skin excision is replaced by specific plastic surgery, treatment of the muscle radiation injury nonetheless remains difficult, for it involves a massive muscle defect in an unpredictable environment, subject to inflammatory waves weeks to months after irradiation, which delay healing and predispose the patient to the development of fibrous scar tissue...
November 8, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/30406335/short-message-service-sms-surveys-assessing-pre-exposure-prophylaxis-prep-adherence-and-sexual-behavior-are-highly-acceptable-among-hiv-uninfected-members-of-serodiscordant-couples-in-east-africa-a-mixed-methods-study
#14
Timothy R Muwonge, Kenneth Ngure, Elly Katabira, Nelly Mugo, Grace Kimemia, Bridget Frances O'Rourke Burns, Nicholas Musinguzi, Felix Bambia, Jared M Baeten, Renee Heffron, Jessica E Haberer
Short message service (SMS) surveys are a promising data collection method and were used to measure sexual behavior and adherence to HIV pre-exposure prophylaxis (PrEP) among HIV-uninfected partners of serodiscordant couples enrolled in a sub-study of the Partners Demonstration Project (an open-label study of integrated antiretroviral therapy and PrEP for HIV prevention in Kenya and Uganda). Questionnaires were completed by 142 participants after study exit. Median age was 29 years; 69% were male. Ninety-five percent (95%) felt SMS surveys were "easy" or "very easy", 74% reported no challenges, and 72% preferred SMS surveys over in-person study visits...
November 7, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/30398934/treating-mucormycosis-using-a-multimodality-approach-a-case-series
#15
Anubhav K Gupta, Chirayu Parwal, Mahesh Mangal, Swaroop Singh Gambhir, Bheem Singh Nanda, Kiranmoy Sarangi
Most fungal infections found in wounds are secondary or superadded, and are generally benign in their clinical course in healthy individuals, with the exception of mucormycosis. This is a life-threatening infection caused by fungi of the order Mucorales. Primary cutaneous disease may occur following traumatic implantation of spores, or use of contaminated bandages, or as a complication of extensive burns, diabetic acidosis and other specific immunocompromised conditions. The clinical spectrum is highly non-specific and is often triggered by seemingly innocuous trauma...
November 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/30398062/on-demand-dissolvable-self-healing-hydrogel-based-on-carboxymethyl-chitosan-and-cellulose-nanocrystal-for-deep-partial-thickness-burn-wound-healing
#16
Weijuan Huang, Yixiang Wang, Zhiqiang Huang, Xiaolan Wang, Lingyun Chen, Yu Zhang, Lina Zhang
Deep partial thickness burn wounds present big challenges due to the long healing time, large size and irregular shape, pain and reinjury at wound dressing changes, as well as scarring. The clinically effective therapy to alleviate pain at wound dressing changes, and the scar left on the skin after the healing of wound is still unavailable. To combat this, we develop a nanocomposite self-healing hydrogel that can be injected into irregular and deep burn wound beds and subsequently rapidly self-heal to reform into an integrated piece of hydrogel that thoroughly fills the wound area and protects the wound site from external environment, finally being painlessly removed by on-demand dissolving using amino acid solution at wound dressing changes, which accelerates deep partial thickness burn wound healing and prevents scarring...
November 16, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/30397573/nortriptyline-induced-oral-ulceration-a-case-report
#17
William Olsufka, Danielle Cabral, Megan McArdle, Rebecca Kavanagh
Drug-induced oral ulcers are lesions of the oral mucosa accompanied by painful symptoms, such as burning mouth, metallic taste, dysgeusia, or ageusia. This report demonstrates the first documented case of drug-induced oral ulcers with the tricyclic antidepressant nortriptyline. In this case, a 49-year-old female initiated treatment for refractory neuropathy with nortriptyline. Within 2 weeks of therapy, painful, oral, bubble-like ulcers developed. Complete symptom resolution occurred approximately 1 month after discontinuation of nortriptyline...
November 2018: The mental health clinician
https://www.readbyqxmd.com/read/30397412/insights-into-the-evaluation-and-management-of-dyspepsia-recent-developments-and-new-guidelines
#18
REVIEW
Christopher J Black, Lesley A Houghton, Alexander C Ford
Dyspepsia is a very common gastrointestinal (GI) condition worldwide. We critically examine the recommendations of recently published guidelines for the management of dyspepsia, including those produced jointly by the American College of Gastroenterology and the Canadian Association of Gastroenterology, and those published by the UK National Institute for Health and Care Excellence. Dyspepsia is a symptom complex, characterized by a range of upper GI symptoms including epigastric pain or burning, early satiety, and post-prandial fullness...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/30391062/effects-of-obesity-on-burn-resuscitation
#19
Jennifer Rosenthal, Audra Clark, Stephanie Campbell, Melanie McMahon, Brett Arnoldo, Steven E Wolf, Herb Phelan
The effects of obesity on resuscitation after severe burn are not well understood. Formulas to calculate 24-h resuscitation volumes incorporate body weight, which in obese patients often leads to excessive fluid administration and potential complications such as pulmonary edema, extremity or abdominal compartment syndrome, and longer mechanical ventilation. We evaluated the impact of obesity on 24-h fluid resuscitation after severe burn using a cohort of 145 adults admitted to the burn ICU from January 2014 to March 2017 with >20% total body surface area burns...
October 31, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/30381374/mirtazapine-added-to-ssris-or-snris-for-treatment-resistant-depression-in-primary-care-phase-iii-randomised-placebo-controlled-trial-mir
#20
David S Kessler, Stephanie J MacNeill, Deborah Tallon, Glyn Lewis, Tim J Peters, William Hollingworth, Jeff Round, Alison Burns, Carolyn A Chew-Graham, Ian M Anderson, Tom Shepherd, John Campbell, Chris M Dickens, Mary Carter, Caroline Jenkinson, Una Macleod, Helen Gibson, Simon Davies, Nicola J Wiles
OBJECTIVE: To investigate the effectiveness of combining mirtazapine with serotonin-noradrenaline reuptake inhibitor (SNRI) or selective serotonin reuptake inhibitor (SSRI) antidepressants for treatment resistant depression in primary care. DESIGN: Two parallel group multicentre phase III randomised placebo controlled trial. SETTING: 106 general practices in four UK sites; Bristol, Exeter, Hull, and Keele/North Staffs, August 2013 to October 2015...
October 31, 2018: BMJ: British Medical Journal
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