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V E Guzhin, A V Cherepanov, V M Dzhafarov
AIM: To present own experience in surgical treatment of cervical paragangliomas. MATERIAL AND METHODS: 9 patients with cervical paragangliomas were enrolled. Endovascular embolization of supplying vessels followed by maximally radical surgery and subsequent carotid arteries repair involved into tumoral process reduces the risk of complications. RESULTS: The most careful attitude to caudal group of cranial nerves adjacent or involved into neoplasm allows to minimize postoperative neurological complications...
2018: Khirurgiia
William Breen, Irina Bancos, William F Young, Keith C Bible, Nadia N Laack, Robert L Foote, Christopher L Hallemeier
Purpose/Objectives: To evaluate the role of external beam radiation therapy (EBRT) for treatment of malignant paraganglioma (PGL) and pheochromocytoma (PCC). Methods and materials: A retrospective review was performed of all patients with malignant PGL/PCC treated with EBRT at our institution between 1973 and 2015. Local control (LC) per treated lesion and overall survival were estimated using the Kaplan-Meier method. Toxicities were scored using the Common Toxicity Criteria for Adverse Events (AE), version 4...
January 2018: Advances in Radiation Oncology
Aya Ikeda, Kiyoto Shiga, Katsunori Katagiri, Daisuke Saito, Jun Miyaguchi, Shin-Ichi Oikawa, Kodai Tsuchida, Takahiro Asakage, Hiroyuki Ozawa, Ken-Ichi Nibu, Naoki Ohtsuki, Yasushi Fujimoto, Ken-Ichi Kaneko
There has been no attempt to clarify the status of patients with carotid body tumor (CBT) in Japan. This multi-institutional survey analyzed patients with CBT throughout Japan by gathering information on these patients from institutions that performed head and neck surgeries. Information from a total of 150 patients from 25 institutions from the past 20 years was employed in the present survey. There were 87 females and 63 males, and their mean age was 48.0 years old. The most common chief complaint was a neck mass and the mean suffering period was 46...
April 2018: Oncology Letters
Yuzhi Zuo, Xiaoxin Li, Xingcheng Wu, Jing Zhou, Jianyi Wang, Jing Wang, Zhihong Wu, Hanzhong Li, Xuebin Zhang
Pheochromocytoma and paraganglioma (PPGLs) are rare autosomal dominant disorders derived from the neural crest chromaffin tissuesof the autonomic nervous system. The succinate dehydrogenase complex subunit D (SDHD) gene has been implicated as one of the pathogenic genes. Although more than 100 SDHD mutations have been reported, the phenotype-genotype association remains unclear. Here we reported a case of a patient who presented with multifocal PPGLs and with a rare SDHD mutation. It is the first report linking this variant to multifocal PPGLs...
March 12, 2018: Urology
(no author information available yet)
No abstract text is available yet for this article.
March 9, 2018: Journal of Clinical Endocrinology and Metabolism
Gozde Sahin, Ceyhan Ugurluoglu, Serra Akar, Ayhan Gul, Aysegul Kebapcilar, Cetin Celik
No abstract text is available yet for this article.
March 14, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Christoph Rischpler, Kristina Schwamborn, Markus Schwaiger, Tobias Maurer
No abstract text is available yet for this article.
February 2018: Nuklearmedizin. Nuclear Medicine
Ying Pang, Garima Gupta, Chunzhang Yang, Herui Wang, Thanh-Truc Huynh, Ziedulla Abdullaev, Svetlana D Pack, Melanie J Percy, Terence R J Lappin, Zhengping Zhuang, Karel Pacak
BACKGROUND: The role of the hypoxia signaling pathway in the pathogenesis of pheochromocytoma/paraganglioma (PPGL)-polycythemia syndrome has been elucidated. Novel somatic mutations in hypoxia-inducible factor type 2A (HIF2A) and germline mutations in prolyl hydroxylase type 1 and type 2 (PHD1 and PHD2) have been identified to cause upregulation of the hypoxia signaling pathway and its target genes including erythropoietin (EPO) and its receptor (EPOR). However, in a minority of patients presenting with this syndrome, the genetics and molecular pathogenesis remain unexplained...
March 13, 2018: BMC Cancer
Ali Harati, Rolf Schultheiß, Stefan Rohde, Thomas Deitmer
BACKGROUND: Jugulotympanic paraganglioma (JTP) are benign, high-vascularized lesions that frequently invade the jugular foramen, temporal bone, the upper neck, and the posterior fossa cavity, resulting in a wide variety of clinical symptoms. METHODS: In this retrospective study, we assess the clinical symptoms and discuss the individual multidisciplinary treatment and outcome of 22 patients with JTP. RESULTS: In 12 patients, a hearing deficit was the presenting symptom, whereas pulsatile tinnitus and otalgia were present in six and four patients respectively...
March 10, 2018: Journal of Clinical Medicine
Katherine Pollaers, Dean Lisewski
No abstract text is available yet for this article.
March 13, 2018: ANZ Journal of Surgery
Ronald Sahyouni, Hossein Mahboubi, Omid Moshtaghi, Khodayar Goshtasbi, Sammy Sahyouni, Harrison W Lin, Hamid R Djalilian
OBJECTIVE: 1) Perform a meta-analysis of the available data on the outcomes of stereotactic radiosurgery (SRS) for the treatment of temporal bone glomus tumors (GT), and 2) evaluate the collective outcomes of SRS treatment with respect to tumor control. DATA SOURCES: A thorough literature search of the published English-language literature from 2011 to 2016 was performed in PubMed, Ovid, and Cochrane databases using the keywords ("Gamma Knife" or "CyberKnife" or "linear accelerator" or "radiosurgery") and ("glomus jugulare" or "jugular paraganglioma" or "glomus tympanicum")...
April 2018: Otology & Neurotology
Anthony R Onofrio, Jeannie Kwon, Lisa H Kang, Jason Wang
Editor's Note.-RadioGraphics continues to publish radiologic-pathologic case material selected from the American Institute for Radiologic Pathology (AIRP) "best case" presentations. The AIRP conducts a 4-week Radiologic Pathology Correlation Course, which is offered five times per year. On the penultimate day of the course, the best case presentation is held at the American Film Institute Silver Theater and Cultural Center in Silver Spring, Md. The AIRP faculty identifies the best cases, from each organ system, brought by the resident attendees...
March 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
Haitham Odat, Khaled Alawneh, Mohannad Al-Qudah
Jugular paragangliomas are slow growing highly vascular tumors arising from jugular paraganglia. The gold standard of treatment is complete surgical resection. Pre-operative embolization of these highly vascular tumors is essential to reduce intra-operative bleeding, allow safe dissection, and decrease operative time and post-operative complications. Onyx (ethylene-vinyl alcohol copolymer) has been widely used as permanent occluding material for vascular tumors of skull base because of its unique physical properties...
March 7, 2018: Journal of Clinical Medicine
Natasha Pollak, Resha S Soni
Tympanic paragangliomas are uncommon vascular tumors of neural crest origin. Classically these lesions have been surgically managed via a transcanal or transmastoid approach using binocular microscopy. We describe a case in which a tympanic paraganglioma was removed via a transcanal approach, using the endoscope exclusively. Endoscopic ear surgery enhances visualization, helping to ensure complete tumor removal, while reducing unnecessary dissection and its associated morbidity. For small middle ear neoplasms, a purely endoscopic approach is feasible, with excellent results...
September 2017: World Journal of Otorhinolaryngology—Head and Neck Surgery
Makoto Ohtake, Kensuke Tateishi, Hidetoshi Murata, Yoji Nagashima, Shoji Yamanaka, Tetsuya Yamamoto
BACKGROUND: Paragangliomas are generally benign, slow-growing tumors. However, approximately 10-20% are malignant, characterized by distant metastasis. Recently, a germline mutation in succinate dehydrogenase B subunit (SDHB) has been shown to be associated with malignant behavior in paraganglioma. Herein, we present a case of SDHB-negative malignant paraganglioma of the jugular foramen with pseudo-hypoxic microenvironment and unique imaging features on [18 F]-fluoro-2-deoxy-d-glucose positron emission tomography ([18 F]-FDG PET), and discuss the significance of SDHB immunohistochemistry and the potential of [18 F]-FDG PET for clinical management...
March 3, 2018: World Neurosurgery
Anastasiya V Snezhkina, Elena N Lukyanova, Dmitry V Kalinin, Anatoly V Pokrovsky, Alexey A Dmitriev, Nadezhda V Koroban, Elena A Pudova, Maria S Fedorova, Nadezhda N Volchenko, Oleg A Stepanov, Ekaterina A Zhevelyuk, Sergey L Kharitonov, Anastasiya V Lipatova, Ivan S Abramov, Alexander V Golovyuk, Yegor E Yegorov, Khava S Vishnyakova, Alexey A Moskalev, George S Krasnov, Nataliya V Melnikova, Dmitry S Shcherbo, Marina V Kiseleva, Andrey D Kaprin, Boris Y Alekseev, Andrew R Zaretsky, Anna V Kudryavtseva
BACKGROUND: Carotid body tumor (CBT) is a form of head and neck paragangliomas (HNPGLs) arising at the bifurcation of carotid arteries. Paragangliomas are commonly associated with germline and somatic mutations involving at least one of more than thirty causative genes. However, the specific functionality of a number of these genes involved in the formation of paragangliomas has not yet been fully investigated. METHODS: Exome library preparation was carried out using Nextera® Rapid Capture Exome Kit (Illumina, USA)...
February 13, 2018: BMC Medical Genomics
Amy L Dimachkieh, Allison Dobbie, Damon R Olson, Mark A Lovell, Jeremy D Prager
OBJECTIVE: To review tracheal paragangliomas and describe the clinical presentation, radiologic findings, operative management, and histologic findings of a pediatric patient who presented with stridor refractory to traditional asthma therapy. METHODS: Chart review of an 8-year-old male who presented to a tertiary care pediatric hospital and literature review of tracheal paragangliomas. RESULTS: We present the case of an 8-year-old male who presented with new-onset of wheezing and dyspnea on exertion...
April 2018: International Journal of Pediatric Otorhinolaryngology
Chung Thong Lim, Márta Korbonits
Pituitary adenomas are the third most common central nervous system tumours and arise from the anterior pituitary within the pituitary fossa. The signs and symptoms of patients with pituitary adenomas vary from 'mass effects' caused by a large adenoma to features secondary to excess pituitary hormones produced by the functioning pituitary adenoma. Detailed histopathological assessment, based on novel classifications and the latest WHO guidelines, helps to categorise pituitary adenomas into different subtypes and identify features that, in some cases, help to predict their behaviour...
March 2, 2018: Endocrine Practice
Xiaoping Yi, Youming Zhang, Chunhui Zhou, Guanghui Gong, Hongling Yin, Junjie Zeng, Longfei Liu, Weihua Liao, Xiaoyan Long
OBJECT: To retrospectively review the clinicopathological features and computed tomography (CT) and magnetic resonance imaging (MRI) findings of lumbosacral intraspinal paragangliomas (PGLs). METHODS: Thirteen patients with surgically and pathologically confirmed lumbosacral intraspinal PGLs were enrolled. Their clinicopathological data and imaging findings were retrospectively reviewed. RESULTS: Ten male and 3 female patients with a median age of 43 years (range, 36-74 years) were included...
February 24, 2018: World Neurosurgery
Arian Lasocki, Rodney J Hicks
Technological advances have increased the ability of imaging to provide an accurate preoperative diagnosis of an intracranial mass. We present the case of a patient with metastatic paraganglioma, who presented with headache and depressed conscious state. We had chronic tachycardia and low-grade fevers due to increased catecholamine secretion, which limited his clinical assessment. The combination of novel positron emission tomography tracers and advanced magnetic resonance imaging techniques was able to provide a confident preoperative diagnosis of a pyogenic intracranial abscess, which was not suspected clinically...
February 26, 2018: Journal of Medical Imaging and Radiation Oncology
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