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https://www.readbyqxmd.com/read/28916220/thoracic-dumbbell-shaped-paraganglioma-arising-in-extra-adrenal-area-a-case-report-and-literature-review
#1
Mikito Tsushima, Shiro Imagama, Kei Ando, Kazuyoshi Kobayashi, Kenyu Ito, Akiyuki Matsumoto, Yoshihiro Nishida, Naoki Ishiguro
No abstract text is available yet for this article.
September 12, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28915965/can-cerebellin-and-renalase-measurements-contribute-to-the-elimination-of-false-positive-results-in-pheochromocytoma-and-paraganglioma-diagnoses
#2
EDITORIAL
Suleyman Aydin
No abstract text is available yet for this article.
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28904054/a-13-steroid-serum-panel-based-on-lc-ms-ms-use-in-detection-of-adrenocortical-carcinoma
#3
David R Taylor, Lea Ghataore, Lewis Couchman, Royce P Vincent, Ben Whitelaw, Dylan Lewis, Salvador Diaz-Cano, Gabriele Galata, Klaus-Martin Schulte, Simon Aylwin, Norman F Taylor
BACKGROUND: Adrenocortical carcinoma (ACC) is a rare malignancy, with an annual incidence of 1 or 2 cases per million. Biochemical diagnosis is challenging because up to two-thirds of the carcinomas are biochemically silent, resulting from de facto enzyme deficiencies in steroid hormone biosynthesis. Urine steroid profiling by GC-MS is an effective diagnostic test for ACC because of its capacity to detect and quantify the increased metabolites of steroid pathway synthetic intermediates...
September 13, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28902732/multimodality-radionuclide-imaging-in-a-patient-with-hereditary-paraganglioma-pheochromocytoma-syndrome
#4
So Y Yim, Valeria M Moncayo, Francisco J Pasquel, Raghuveer K Halkar
Hereditary paraganglioma (PGL)-pheochromocytoma (PCC) syndrome is a genetic disorder caused by a mutation of the tumor suppressor gene SDHD that results in a predisposition for head and neck PGLs and PCCs. We present a case of a 33-year-old woman where F-FDG PET/CT showed areas of increased uptake in both the adrenal and cervical regions, consistent with PCCs and PGLs, respectively. Further imaging revealed that PCCs were I-MIBG avid, whereas the PGLs were In-octreotide avid. This demonstrates the varying sensitivities of different imaging modalities in regard to neuroendocrine tumors and the potential for treatment using multiple targeted therapies...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28900474/malignant-extra-adrenal-pelvic-paraganglioma-in-a-paediatric-patient
#5
Gabriel Cao, Julian Mendez, Daniel Navacchia
The extra-adrenal paraganglioma is a neoplasm originating in regional structures, uncommon in paediatrics. We report on a case of a 13-year-old patient who began with severe arterial hypertension, tachycardia, dilated cardiomyopathy and elevated levels of catecholamines in the blood and urine. The presence of a retrovesical pelvic mass in contact with the right vaginal dome was determined by imaging studies. A diagnosis of malignant extra-adrenal pelvic paraganglioma with lymph node metastases was reached through biopsy and the surgical resection of subsequent local recurrences...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28894884/characterization-of-skull-base-lesions-using-pseudo-continuous-arterial-spin-labeling
#6
B Geerts, D Leclercq, S Tezenas du Montcel, B Law-Ye, S Gerber, D Bernardeschi, D Galanaud, D Dormont, N Pyatigorskaya
PURPOSE: Pseudo-continuous arterial spin labeling (pCASL) is a non-invasive magnetic resonance (MR) perfusion technique. Our study aimed at estimating the diagnostic performance of the pCASL sequence in assessing the perfusion of skull base lesions both qualitatively and quantitatively and at providing cut-off values for differentiation of specific skull base lesions. METHODS: In this study 99 patients with histopathologically confirmed skull base lesions were retrospectively enrolled...
September 11, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28891197/primary-mediastinal-paraganglioma-associated-with-a-familial-variant-in-the-succinate-dehydrogenase-b-subunit-gene
#7
Nardin Samuel, Resham Ejaz, Josh Silver, Shereen Ezzat, Robert J Cusimano, Raymond H Kim
Surgical management is the mainstay of therapy for primary cardiac tumors, yet due to the rarity of these malignancies, their management and workup remains a challenge. Here, we report a unique case of a patient with a primary left ventricular cardiac paraganglioma (PGL) and describe the role of a medical genetics assessment leading to the identification of a rare variant in the SDHB gene to be the causative etiology of this cardiac tumor. Due to decreasing costs and accessibility of molecular genetic analysis, genetic testing may become an emerging diagnostic adjunct in cases of cardiac tumors...
September 10, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28890865/functional-imaging-of-paragangliomas-with-an-emphasis-on-von-hippel-lindau-associated-disease-a-mini-review
#8
REVIEW
Ioannis Ilias, Georgios Meristoudis
Few reports have presented data and results on functional (i.e., nuclear medicine) imaging of paragangliomas and pheochromocytomas (PGLs/PHEOs) for von Hippel-Lindau (VHL) patients. Nuclear medicine localization modalities for chromaffin tumors can be specific or nonspecific. Specific methods make use of the expression of the human norepinephrine transporter (hNET) and vesicular monoamine transporters (VMATs) by these tumors. These permit the use of radiolabeled ligands that enter the synthesis and storage pathway of catecholamines...
2017: Journal of Kidney Cancer and VHL
https://www.readbyqxmd.com/read/28889717/-a-case-of-primary-schwannoma-of-the-urinary-bladder
#9
Yoshitaka Matsumoto, Natsui Waku, Koji Kawai, Atsushi Ikeda, Tomokazu Kimura, Ryutaro Ishitsuka, Takahiro Kojima, Takahiro Suetomi, Akira Joraku, Jun Miyazaki, Mai Sakashita, Hiroyuki Nishiyama
A 68-year-old woman presented with a bladder tumor. She was asymptomatic, and the tumor was incidentally detected with radiological imaging performed during treatment of cervical cancer. Magnetic resonance imaging and computed tomography revealed a solitary submucosal tumor located in the anterior wall of the urinary bladder, with homogeneous contrast enhancement. Cystoscopy showed a submucosal tumor covered by normal mucosa. A paraganglioma was considered in the differential diagnosis, but symptoms suggesting hypercatecholaminemia were not apparent...
August 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28884434/clinical-predictors-of-malignancy-in-patients-with-pheochromocytoma-and-paraganglioma
#10
Mashaal Dhir, Wei Li, Melissa E Hogg, David L Bartlett, Sally E Carty, Kelly L McCoy, Sue M Challinor, Linwah Yip
BACKGROUND AND PURPOSE: Factors associated with malignancy in patients with pheochromocytoma (adrenal tumors, Pheo) and paraganglioma (extra-adrenal, PGL) are not well-defined and all patients require lifelong surveillance. The primary aim of our study was to determine genetic and clinical variables associated with malignancy in patients with Pheo/PGL. METHODS: Single institution retrospective review was performed of all patients who underwent surgery (1/95-1/15) for Pheo/PGL...
September 7, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28878589/diagnostic-imaging-and-treatment-of-a-left-atrial-paraganglioma
#11
Amir Gahremanpour, Gregory Pattakos, Ross M Reul, Madjid Mirzai-Tehrane
No abstract text is available yet for this article.
August 2017: Texas Heart Institute Journal
https://www.readbyqxmd.com/read/28875382/-tumors-of-the-inner-ear-and-adjacent-structures
#12
REVIEW
J Schittenhelm
Tumors of the inner ear and adjacent structures often present with hearing loss, tinnitus and vertigo due to compression of the traversing cranial nerves. More than 90% of the tumors of the inner ear with or without expansion into the cerebellopontine angle are histologically diagnosed as vestibular schwannomas. Less common tumorous lesions include ectopic meningiomas located in the petrous bone, glomus tympanicum paragangliomas or endolymphatic sac tumors (ELST) originating in the vestibular recess. Most tumors are sporadic, but hereditary disorders have to be considered...
September 5, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28867159/new-insights-into-the-nuclear-imaging-phenotypes-of-cluster-1-pheochromocytoma-and-paraganglioma
#13
REVIEW
David Taïeb, Karel Pacak
Pheochromocytomas and paragangliomas (PPGLs) belong to the family of neural crest cell-derived neoplasms. In up to 70% of cases they are associated with germline and somatic mutations in 15 well-characterized PPGL driver or fusion genes. PPGLs can be grouped into three main clusters, where cluster 1 includes PPGLs characterized by a pseudohypoxic signature. Although cluster 1 tumors share several common features, they exhibit unique behaviors. We present here unique insights into the imaging phenotypes of cluster 1 PPGLs based on glucose uptake, catecholamine metabolism, and somatostatin receptor expression...
August 31, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28864611/norepinephrine-transporter-as-a-target-for-imaging-and-therapy
#14
Neeta Pandit-Taskar, Shakeel Modak
The norepinephrine transporter (NET) is essential for norepinephrine uptake at the synaptic terminals and adrenal chromaffin cells. In neuroendocrine tumors, NET can be targeted for imaging as well as therapy. One of the most widely used theranostic agents targeting NET is metaiodobenzylguanidine (MIBG), a guanethidine analog of norepinephrine. (123)I/(131)I-MIBG theranostics have been applied in the clinical evaluation and management of neuroendocrine tumors, especially in neuroblastoma, paraganglioma, and pheochromocytoma...
September 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28863727/soluble-endoglin-cd105-serum-level-as-a-potential-marker-in-the-management-of-head-and-neck-paragangliomas
#15
Małgorzata Litwiniuk, Kazimierz Niemczyk, Justyna Niderla-Bielińska, Izabela Łukawska-Popieluch, Tomasz Grzela
OBJECTIVES: To assess the expression of endoglin in head and neck paragangliomas and the soluble endoglin level in serum of paraganglioma patients. METHODS: Seven tumor samples of patients operated for cervical paraganglioma were assessed, as well as serum samples collected preoperatively, on days 4 and 28 postoperation. Serum level of endoglin in healthy controls was also determined. Tumor samples were subjected to immunofluorescent staining and examined with confocal microscope...
September 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28858847/pheochromocytoma-diagnosis-and-treatment-review-of-the-literature
#16
F A Farrugia, G Martikos, P Tzanetis, A Charalampopoulos, E Misiakos, N Zavras, D Sotiropoulos
OBJECTIVE: We conducted an extensive review of the literature and tried to cite the most recent recommendations concerning the pheochromocytoma (PHEO). METHODS: Pub Med and Google Scholar databases were searched systematically for studies concerning pheochromocytomas (intra-adrenal paragangliomas) from 1980 until 2016. Bibliographies were searched to find additional articles. RESULTS: More than four times elevation of plasma fractionated metanephrines or elevated 24-h urinary fractionated metanephrines are keys to diagnosing pheochromocytoma...
July 1, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28856331/phaeochromocytoma-and-paraganglioma-excision-involving-the-great-vessels
#17
U Srirangalingam, K Gunganah, R Carpenter, S Bhattacharya, S J Edmondson, W M Drake
OBJECTIVE/BACKGROUND: Phaeochromocytomas and paragangliomas are vascular neuroendocrine tumours distributed between the neck and the pelvis and may be associated with catecholamine secretion. The aim of the study was to describe the complex surgical management required to excise these tumours when in close proximity to the great vessels (aorta and vena cava). METHODS: This was a retrospective case series. Patients included those undergoing surgical excision of a phaeochromocytoma or paraganglioma involving the great vessels...
2017: EJVES Short Rep
https://www.readbyqxmd.com/read/28855235/evaluation-of-a-novel-germline-tmem127-mutation-in-an-uncommon-presentation
#18
Yilun Deng, Shahida K Flores, Zi-Ming Cheng, Yuejuan Qin, Robin C Schwartz, Carl D Malchoff, Patricia Dahia
Germline mutations of the endomembrane-encoding gene TMEM127 confers susceptibility to neural crest-derived tumors pheochromocytomas (PHEOs) and have also been found in isolated renal cell carcinomas (RCCs). PHEOs and RCCs can arise as a result of shared inherited susceptibility, as in von Hippel Lindau disease and in PHEO-paraganglioma syndromes related to mutations in succinate dehydrogenase (SDH) subunit genes. The clinical spectrum and the signaling consequences of TMEM127 mutations remain poorly defined and it is not clear whether both tumors can be associated in families...
August 30, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28850312/favorable-and-durable-response-to-pazopanib-in-metastatic-refractory-paraganglioma
#19
Sandipkumar Patel, Dwight Owen, Carl R Schmidt, Lawrence S Kirschner, John Phay, Lawrence Shirley, Mary Dillhoff, Pamela Brock, Allan Espinosa, Manisha H Shah, Bhavana Konda
No abstract text is available yet for this article.
August 29, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28848772/aa-amylodisis-associated-with-jugular-paraganglioma-as-a-rare-cause-of-chronic-diarrhea
#20
José M Olmos-Martínez, Remigio Mazorra, Cristina Magadán, Luis Martín, Javier Crespo
We report a case of a 64-year-old man with chronic diarrhea who was diagnosed of a systemic reactive (AA) amyloidosis associated with a jugular paraganglioma. This neoplasm was diagnosed 30 years previously and it was not removed after extensive evaluation by a multidisciplinary team. Chronic inflammatory diseases are the major cause of AA amyloidosis. However, benign tumors, such as jugular paragangliomas, are considered to be one of the tumors that can result in AA amyloidosis.
2017: ACG Case Reports Journal
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