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Mozhgan Nasr Azadani, Nasser Ghadiri, Ensieh Davoodijam
OBJECTIVE: Automatic text summarization offers an efficient solution to access the ever-growing amounts of both scientific and clinical literature in the biomedical domain by summarizing the source documents while maintaining their most informative contents. In this paper, we propose a novel graph-based summarization method that takes advantage of the domain-specific knowledge and a well-established data mining technique called frequent itemset mining. METHODS: Our summarizer exploits the Unified Medical Language System (UMLS) to construct a concept-based model of the source document and mapping the document to the concepts...
June 12, 2018: Journal of Biomedical Informatics
Zi-Wen Long, Jiang-Hong Wu, Cai- Hong, Ya-Nong Wang, Ye Zhou
Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. In order to investigate a new treatment fot GIST, we hypothesized the effect of miR-374b targeting PTEN gene-mediated PI3K/Akt signal transduction pathway on proliferation and apoptosis of human gastrointestinal stromal tumor (GIST) cells. We obtained GIST tissues and adjacent normal tissues from 143 patients with GIST to measure the levels of miR- 374b, PTEN, PI3K, Akt, caspase9, Bax, MMP2, MMP9, ki67, PCNA, P53 and cyclinD1...
June 14, 2018: Molecules and Cells
Simone Rodda, Stephanie S Merkouris, Charles Abraham, David C Hodgins, Sean Cowlishaw, Nicki A Dowling
Background and aims To date, no systematic approach to identifying the content and characteristics of psychological interventions used to reduce gambling or problem gambling has been developed. This study aimed to develop a reliable classification system capable of identifying intervention characteristics that could, potentially, account for greater or lesser effectiveness. Methods Intervention descriptions were content analyzed to identify common and differentiating characteristics. A coder manual was developed and applied by three independent coders to identify the presence or absence of defined characteristics in 46 psychological and self-help gambling interventions...
June 13, 2018: Journal of Behavioral Addictions
Peter Reichardt
No abstract text is available yet for this article.
June 13, 2018: Oncology Research and Treatment
Akihiro Hayashi, Mirai Edano, Kazunori Maeda, Atsushi Yanagitani, Kiwamu Tanaka, Hajime Isomoto
Abdominal ultrasonography revealed a low echoic mass in the upper abdomen of a 65-year-old man. He was referred to our department, where abdominal CT revealed a tumor with a 30-mm contrast effect on the distal side of the inferior part of the duodenum. Endoscopy revealed a submucosal tumor in the same region, and ultrasonic endoscopy showed a low echoic mass with a clear boundary derived from the muscle layer. The duodenum was partially resected based on a diagnosis of suspected gastrointestinal stromal tumors (GIST), and the skin tumor was simultaneously resected...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Alyssa Truman, Liad Mudrik
Objects in the real world typically appear within a broader context, having relationships with the environment. Do these relations between objects and the contexts in which they appear affect object identification? Previous findings of an N300 component evoked by scene-incongruent objects were taken as evidence for such an effect, since N300 is held to reflect object identification processes. Yet this conjuncture was never directly tested, and ignores differences between the fronto-central incongruency-evoked N300 and the typically bi-polar fronto-occipital identification-related N300...
June 7, 2018: Neuropsychologia
E Serrano-Candelas, E Ainsua-Enrich, A Navinés-Ferrer, P Rodrigues, A García-Valverde, S Bazzocco, I Macaya, J Arribas, C Serrano, J Sayós, D Arango, M Martin
Gastrointestinal stromal tumors (GISTs) represent about 80% of the mesenchymal neoplasms of the gastrointestinal tract. Most GISTs contain oncogenic KIT (85%) or PDGFRA (5%) receptors. The kinase inhibitor imatinib mesylate is the preferential treatment for these tumors; however, the development of drug resistance has highlighted the need for novel therapeutic strategies. Recently, we reported that the adaptor molecule SH3 Binding Protein 2 (SH3BP2) regulates KIT expression and signaling in human mast cells...
June 9, 2018: Molecular Oncology
Patrick C Brennan, Ziba Gandomkar, Ernest U Ekpo, Kriscia Tapia, Phuong D Trieu, Sarah J Lewis, Jeremy M Wolfe, Karla K Evans
Radiologists can detect abnormality in mammograms at above-chance levels after a momentary glimpse of an image. The study investigated this instantaneous perception of an abnormality, known as a "gist" response, when 23 radiologists viewed prior mammograms of women that were reported as normal, but later diagnosed with breast cancer at subsequent screening. Five categories of cases were included: current cancer-containing mammograms, current mammograms of the normal breast contralateral to the cancer, prior mammograms of normal cases, prior mammograms with visible cancer signs in a breast from women who were initially reported as normal, but later diagnosed with breast cancer at subsequent screening in the same breast, and prior mammograms without any visible cancer signs from women labelled as initially normal but subsequently diagnosed with cancer...
June 7, 2018: Scientific Reports
Shawn J Mendonca, Alejandro Sanchez, Kyle A Blum, Mazyar Ghanaat, Mahyar Y Kashan, Nicole Benfante, Paul Russo, Jonathan A Coleman, Aimee M Crago, A Ari Hakimi
BACKGROUND AND OBJECTIVES: Prior small studies have reported a possible association between renal cell carcinoma (RCC) and gastrointestinal stromal tumors (GISTs). In the largest known series, our objective was to describe the prevalence of RCC among patients with GISTs over 26 years at Memorial Sloan Kettering Cancer Center (MSKCC). METHODS: We retrospectively reviewed MSKCC's prospectively maintained sarcoma and RCC databases and identified all patients with both RCC and GIST between 1980 and 2016...
June 7, 2018: Journal of Surgical Oncology
Richard H Row, Amy Pegg, Brian Kinney, Gist H Farr, Lisa Maves, Sally Lowell, Valerie Wilson, Benjamin Louis Martin
The mesodermal germ layer is patterned into mediolateral subtypes by signaling factors including BMP and FGF. How these pathways are integrated to induce specific mediolateral cell fates is not well understood. We used mesoderm derived from post-gastrulation neuromesodermal progenitors (NMPs), which undergo a binary mediolateral patterning decision, as a simplified model to understand how FGF acts together with BMP to impart mediolateral fate. Using zebrafish and mouse NMPs, we identify an evolutionarily conserved mechanism of BMP and FGF mediated mediolateral mesodermal patterning that occurs through modulation of basic helix-loop-helix (bHLH) transcription factor activity...
June 7, 2018: ELife
Zejian Lyu, Zifeng Yang, Junjiang Wang, Weixian Hu, Yong Li
BACKGROUND: The most common laparoscopic surgery for gastric gastrointestinal stromal tumors (GISTs) currently includes laparoscopic wedge resection, laparoscopic transgastric surgery, and laparoscopic intragastic surgery [Ohashi in Surg Endosc 9:169-171, 1995]. METHODS: The clinical data of 10 cases of cardiac endophytic GIST patients who received total laparoscopic intragastric surgery from June 2014 to March 2016 in Guangdong General Hospital were retrospectively analyzed...
June 6, 2018: Annals of Surgical Oncology
Ankit Chhoda, Deepanshu Jain, Venkateswar R Surabhi, Shashideep Singhal
The histologic analysis of gastrointestinal stromal tumors (GISTs) is a common method to detect the mitotic activity and to subsequently determine the risk of GISTs for malignancy. The potential false negative error due to inadequate yield of specimens and actual determination of malignancy risk requires analysis of the whole tumor. We aimed to assess the role of contrast enhanced endoscopic ultrasound (CE-EUS) in the management of GISTs. Two authors individually did review of English literatures to identify nine peer-reviewed original articles using keywords- contrast endoscopic ultrasound, GIST and submucosal tumor...
May 2018: Clinical Endoscopy
Ali Aghdassi, Agnes Christoph, Frank Dombrowski, Paula Döring, Christoph Barth, Jan Christoph, Markus M Lerch, Peter Simon
BACKGROUND AND AIMS: Gastrointestinal stromal tumors (GISTs) are rare malignancies but the most common mesenchymal tumors of the digestive tract. Recent advances in diagnostic imaging and an increasing incidence will confront us more frequently with stromal tumors. This single center study aimed to characterize GIST patients in terms of tumor location, clinical presentation, metastasis formation, as well as associated secondary malignancies. METHODS: In a retrospective study, 104 patients with a histologically confirmed diagnosis of GIST, collected between 1993 and 2011, were characterized for several clinical features...
June 5, 2018: Digestive Diseases
Lin Mei, Wei Du, Michael Idowu, Margaret von Mehren, Sosipatros A Boikos
Gastrointestinal stromal tumors (GISTs) originate from interstitial cells of Cajal and account for over 5,000 newly diagnosed cases in the United States. The discovery of activated KIT and PDGFRA mutations and introduction of imatinib revolutionized the treatment strategy and opened up the new era of target therapy for solid tumors. Although surgery remains the primary modality of treatment for curative purpose, almost half of the patients experienced disease recurrence. Tailoring (neo)-adjuvant treatment with imatinib is ongoing to meet the need for an effective therapy...
2018: Frontiers in Oncology
Matthew L Hemming, Matthew A Lawlor, Rhamy Zeid, Tom Lesluyes, Jonathan A Fletcher, Chandrajit P Raut, Ewa T Sicinska, Frédéric Chibon, Scott A Armstrong, George D Demetri, James E Bradner
Activating mutations in the KIT or PDGFRA receptor tyrosine kinases are hallmarks of gastrointestinal stromal tumor (GIST). The biological underpinnings of recurrence following resection or disease progression beyond kinase mutation are poorly understood. Utilizing chromatin immunoprecipitation with sequencing of tumor samples and cell lines, we describe the enhancer landscape of GIST, highlighting genes that reinforce and extend our understanding of these neoplasms. A group of core transcription factors can be distinguished from others unique to localized and metastatic disease...
June 4, 2018: Proceedings of the National Academy of Sciences of the United States of America
Douglas Morte, Jason Bingham, Vance Sohn
Background: Glomus tumors are uncommon mesenchymal neoplasms originating from modified smooth muscle cells in the glomus body. They are generally small, solitary lesions found in the distal extremities. Rarely, involvement in the abdominal viscera can occur. In such cases, hematemesis/melena and epigastric discomfort are the most common initial symptoms. Although gastric glomus tumors can demonstrate malignant behavior, criteria for identifying malignant potential have yet to be established...
2018: Case Reports in Gastrointestinal Medicine
Soichi Ito, Yuma Tsuchitani, Yuro Kim, Souhei Hashimoto, Yuichi Miura, Takuji Uemura, Kazunori Katsura, Takayuki Abe, Koichiro Sato, Hirotaka Kato
INTRODUCTION: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. The small intestine is the second-most frequent location where GISTs occur after the stomach. Attention should be paid to small intestinal GISTs because they infrequently present with acute abdomen, which necessitates emergency surgery. This report describes a patient with a small intestinal GIST developing a giant intratumoral abscess, in whom emergency surgery was performed...
May 29, 2018: International Journal of Surgery Case Reports
Apostolos Gaitanidis, Mustapha El Lakis, Michail Alevizakos, Alexandra Tsaroucha, Michail Pitiakoudis
BACKGROUND: Lymph node metastasis is not common among patients with gastrointestinal stromal tumors (GISTs) and its prognostic value is controversial. The purposes of this study are to identify predictors of lymph node metastasis and determine its prognostic associations. METHODS: A retrospective analysis of the surveillance, epidemiology and end results (SEER) database was performed. Patients with GISTs that underwent surgery and pathologic nodal staging were identified...
May 31, 2018: Langenbeck's Archives of Surgery
Areen Abdulelah Murshid, Hatim Q Al-Maghraby
Desmoid tumors (deep fibromatosis) of the mesentery are rare mesenchymal tumors. They are often misdiagnosed, especially with a previous history of resection for gastrointestinal stromal tumor (GIST). Immunohistochemistry can help differentiate between these two tumors. In this article, we present a case we had encountered: a Desmoid tumor developing in a patient with a history of GIST 3 years ago. It is the first case of GIST with subsequent development of Desmoid tumor to be reported in Saudi Arabia. We discuss the two entities of Desmoid tumor and GIST by comparing their definitions, clinical presentations, histological features, immunohistochemistry stains, molecular pathogenesis, prognosis, and treatment...
2018: Case Reports in Pathology
Young Jae Kim, Woo Jin Lee, Chong Hyun Won, Jee Ho Choi, Mi Woo Lee
We report a case of a 69-year-old man with metastatic cutaneous duodenal gastrointestinal stromal tumor, which led to find multiple metastases on orbital muscle and scalp. The patient presented with a rapidly growing chest nodule with mild tenderness. He underwent surgical resection for duodenal gastrointestinal stromal tumor and had been treated with imatinib for three years. Histopathological examination of the chest nodule was consistent with gastrointestinal stromal tumor. A brain magnetic resonance imaging of follow work-up revealed multiple metastases at the left superior rectus muscle and occipital scalp...
June 2018: Annals of Dermatology
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