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https://www.readbyqxmd.com/read/29054076/genetic-polymorphisms-in-angiogenesis-related-genes-are-associated-with-worse-progression-free-survival-of-patients-with-advanced-gastrointestinal-stromal-tumours-treated-with-imatinib
#1
Michiel C Verboom, Jacqueline S L Kloth, Jesse J Swen, Tahar van der Straaten, Judith V M G Bovée, Stefan Sleijfer, Anna K L Reyners, Ron H J Mathijssen, Henk-Jan Guchelaar, Neeltje Steeghs, Hans Gelderblom
BACKGROUND: Imatinib 400 mg per day is first-line therapy for patients with gastrointestinal stromal tumours (GISTs). Although clinical benefit is high, progression-free survival (PFS) is variable. This study explores the relationship of single nucleotide polymorphisms (SNPs) in genes related to imatinib pharmacokinetics and pharmacodynamics and PFS in imatinib-treated patients with advanced GIST. METHODS: In 227 patients a pharmacogenetic pathway analysis was performed...
October 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29050348/imatinib-dose-escalation-versus-sunitinib-as-a-second-line-treatment-against-advanced-gastrointestinal-stromal-tumors-a-nationwide-population-based-cohort-study
#2
Jun-Te Hsu, Puo-Hsien Le, Chang-Fu Kuo, Meng-Jiun Chiou, Chia-Jung Kuo, Tsung-Hsing Chen, Chun-Jung Lin, Jen-Shi Chen, Huang-Pin Yu, Chun-Nan Yeh, Yi-Yin Jan, Ta-Sen Yeh
BACKGROUND: Although treatment with imatinib in advanced gastrointestinal stromal tumor (GIST) patients has led to significant clinical benefits, the disease will eventually progress due to imatinib resistance. Treatment options after failure of first-line imatinib include imatinib dose escalation or shifting to sunitinib. However, there is no large-scale study to compare the efficacy difference between these two treatment strategies or the role of surgery. RESULTS: This study recruited 521 advanced GIST patients including 246, 125, and 150 placed in groups 1, 2, and 3, respectively...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29049221/percutaneous-microwave-ablation-liver-partition-and-portal-vein-embolization-for-planned-hepatectomy-due-to-large-gastrointestinal-stromal-tumor-metastases-a-case-report
#3
Jie Liu, Chengwu Zhang, Defei Hong, Minjie Shang, Weifeng Yao, Yuan Chen
RATIONALE: The liver is the most frequent site of relapse of gastrointestinal stromal tumors (GISTs). Surgery is always considered to be unsuitable because of the multiple metastases. PATIENT CONCERNS: In this report, we describe a case of large, multiple GIST liver metastases that were treated with percutaneous microwave ablation liver partition and portal vein embolization for planned hepatectomy (PALPP). A 44-year-old woman had undergone pancreaticoduodenectomy 4 years previously because of the diagnosis of a large duodenal GIST...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29046655/change-blindness-is-influenced-by-both-contrast-energy-and-subjective-importance-within-local-regions-of-the-image
#4
Wietske Zuiderbaan, Jonathan van Leeuwen, Serge O Dumoulin
Our visual system receives an enormous amount of information, but not all information is retained. This is exemplified by the fact that subjects fail to detect large changes in a visual scene, i.e., change-blindness. Current theories propose that our ability to detect these changes is influenced by the gist or interpretation of an image. On the other hand, stimulus-driven image features such as contrast energy dominate the representation in early visual cortex (De Valois and De Valois, 1988; Boynton et al., 1999; Olman et al...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29046654/the-effect-of-consistency-on-short-term-memory-for-scenes
#5
Mingliang Gong, Yuming Xuan, Xinwen Xu, Xiaolan Fu
Which is more detectable, the change of a consistent or an inconsistent object in a scene? This question has been debated for decades. We noted that the change of objects in scenes might simultaneously be accompanied with gist changes. In the present study we aimed to examine how the alteration of gist, as well as the consistency of the changed objects, modulated change detection. In Experiment 1, we manipulated the semantic content by either keeping or changing the consistency of the scene. Results showed that the changes of consistent and inconsistent scenes were equally detected...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29042141/involvement-of-bmi-1-gene-in-the-development-of-gastrointestinal-stromal-tumor-by-regulating-p16-ink4a-p14-arf-gene-expressions-an-in-vivo-and-in-vitro-study
#6
Jiang-Li Wang, Jiang-Hong Wu, Cai Hong, Ya-Nong Wang, Ye Zhou, Zi-Wen Long, Ying Zhou, Hai-Shu Qin
OBJECTIVE: This study was conducted in order to explore the role that Bmi-1 plays during the development of a gastrointestinal stromal tumor (GIST) by regulation of the p16(Ink4A) and p14(ARF) expressions. METHODS: Eighty-six patients diagnosed with GIST were selected to take part in this experiment. The Bmi-1 protein expressions in GIST and adjacent normal tissues were detected using immunohistochemistry and further analyzed by using photodensitometry. To monitor and track the progression of the GIST, a 3-year follow-up was conducted for all affected patients...
September 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29028887/identification-of-cancer-driver-genes-in-focal-genomic-aberrations-from-whole-exome-sequencing-data
#7
Ho Jang, Hyunju Lee
Summary: Whole-exome sequencing (WES) data have been used for identifying copy number aberrations in cancer cells. Nonetheless, the use of WES is still challenging for identification of focal aberrant regions in multiple samples that may contain cancer driver genes. In this study, we developed a wavelet-based method for identifying focal genomic aberrant regions in the WES data from cancer cells (WIFA-X). When we applied WIFA-X to glioblastoma multiforme and lung adenocarcinoma datasets, WIFA-X outperformed other approaches on identifying cancer driver genes...
September 28, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29028633/acute-kidney-injury-in-congenital-heart-disease
#8
Katja M Gist, David M Kwiatkowski, David S Cooper
PURPOSE OF REVIEW: Acute kidney injury (AKI) is associated with significant morbidity and mortality in patients with congenital heart disease undergoing cardiac surgery or in pediatric patients with congestive heart failure. RECENT FINDINGS: This review describes the definition and various manifestations of AKI, the impact of biomarkers on the diagnosis of AKI, the importance of fluid overload as a consequence of AKI and its long-term impact. SUMMARY: There are novel biomarkers for AKI detection that should facilitate early recognition and intervention to prevent or attenuate the effects of AKI and fluid overload...
October 11, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/29025047/the-representativeness-of-eligible-patients-in-type-2-diabetes-trials-a-case-study-using-gist-2-0
#9
Anando Sen, Andrew Goldstein, Shreya Chakrabarti, Ning Shang, Tian Kang, Anil Yaman, Patrick B Ryan, Chunhua Weng
Objective: The population representativeness of a clinical study is influenced by how real-world patients qualify for the study. We analyze the representativeness of eligible patients for multiple type 2 diabetes trials and the relationship between representativeness and other trial characteristics. Methods: Sixty-nine study traits available in the electronic health record data for 2034 patients with type 2 diabetes were used to profile the target patients for type 2 diabetes trials...
September 13, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29023148/nonstandardized-terminology-to-describe-focal-liver-lesions-in-patients-at-risk-for-hepatocellular-carcinoma-implications-regarding-clinical-communication
#10
Michael T Corwin, Andrew Y Lee, Ghaneh Fananapazir, Thomas W Loehfelm, Souvik Sarkar, Claude B Sirlin
OBJECTIVE: The purpose of this study is to determine the correlation between malignancy risk of focal liver observations in patients at risk for hepatocellular carcinoma (HCC) implied by phrases used in nonstructured radiology reports with the risk inferred by hepatologists. MATERIALS AND METHODS: We performed a retrospective review of nonstructured radiology reports issued before Liver Imaging and Reporting Data System (LI-RADS) adoption from four-phase liver CT examinations of patients at risk for HCC...
October 12, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29018259/clinicopathological-and-molecular-characteristics-of-synchronous-gastric-adenocarcinoma-and-gastrointestinal-stromal-tumors
#11
Jun-Ming Luo, Fa-Long Cao, Chen Meng, Li-Jun Lin, Si-Qing Ma, Shao-Hua Peng, Hong-Ling Gao, Sara Javidiparsijani, Gui-Rong Wang, Meng-Lan Zhang, Jian-Guo Xin, Yi-Chun Wang, Shu-Kun Zhang
Synchronous gastric tumors that consist of both gastrointestinal stromal tumor (GIST) and adenocarcinoma are rare. We studied the clinicopathological and molecular characteristics of six cases containing both gastric adenocarcinoma and GIST. By means of immunohistochemical analysis, all GIST cells expressed CD117, CD34 and Dog1 in all six synchronous gastric adenocarcinomas with GIST, and in GIST alone. Sequencing analysis demonstrated that exon 11 c-kit mutations were present in two of six synchronous tumors and four of five GISTs...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28994187/performance-of-f-18-fdg-pet-ct-for-predicting-malignant-potential-of-gastrointestinal-stromal-tumors-a-systematic-review-and-meta-analysis
#12
Seong-Jang Kim, Sang-Woo Lee
AIM: We aimed to explore the role of the diagnostic accuracy of F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET) or positron emission tomography/computed tomography (PET/CT) for prediction of malignant potential of gastrointestinal stromal tumor (GIST) through a systematic review and meta-analysis. METHODS: The MEDLINE, EMBASE, and Cochrane Library database, from the earliest available date of indexing through May 31, 2017, were searched for studies evaluating the diagnostic performance of F-18 FDG PET or PET/CT for prediction of malignant potential of GIST...
October 10, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28991465/inhibitors-to-overcome-secondary-mutations-in-the-stem-cell-factor-receptor-kit
#13
Helena Kaitsiotou, Marina Keul, Julia Hardick, Thomas Mühlenberg, Julia Ketzer, Christiane Ehrt, Jasmin Krüll, Federico Medda, Oliver Koch, Fabrizio Giordanetto, Sebastian Bauer, Daniel Rauh
In modern cancer therapy, the use of small organic molecules against receptor tyrosine kinases (RTKs) has been shown to be a valuable strategy. The association of cancer cells with dysregulated signaling pathways linked to RTKs represents a key element in targeted cancer therapies. The tyrosine kinase mast/stem cell growth factor receptor KIT is an example of a clinically relevant RTK. KIT is targeted for cancer therapy in gastrointestinal stromal tumors (GISTs) and chronic myelogenous leukemia (CML). However, acquired resistance mutations within the catalytic domain decrease the efficacy of this therapy and are the most common cause of failed therapy...
October 9, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28990511/sunitinib-in-the-treatment-of-thyroid-cancer
#14
Ferrari Silvia Martinaa, Centanni Marco, Virili Camilla, Miccoli Mario, Ferrari Paola, Ruffilli Ilaria, Ragusa Francesca, Antonelli Alessandro, Fallahi Poupak
BACKGROUND: Sunitinib (SU11248) is an oral, small-molecule, multi-targeted tyrosine kinase inhibitor (TKI), that inhibits receptors for platelet-derived growth factor (PDGF-Rs) and vascular endothelial growth factor receptors (VEGFRs), c-KIT, fms-related tyrosine kinase 3 (FLT3) and RET. The concurrent inhibition of these pathways reduces tumor vascularization and causes cancer cell apoptosis, inducing a tumor shrinkage. Sunitinib is approved for the treatment of imatinib-resistant gastrointestinal stromal tumor (GIST), renal carcinoma, and pancreatic neuroendocrine tumors...
October 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28988888/small-bowel-tumors-a-digestive-endoscopy-society-of-taiwan-dest-multicenter-enteroscopy-based-epidemiologic-study
#15
Chen-Shuan Chung, Chi-Ming Tai, Tien-Yu Huang, Chen-Wang Chang, Kuan-Chih Chen, Chao-Ming Tseng, Horng-Yuan Wang, Cheng-Hsin Chu, Jiann-Ming Wu, Yun Chen, Hsiu-Po Wang
BACKGROUND/PURPOSE: Small bowel (SB) accounts for the majority of gastrointestinal tract but its tumors are rare and always overlooked. In this study, we aimed to evaluate the epidemiology of SB tumors. METHODS: This multicenter retrospective study utilized endoscopy database from 2006/11 to 2016/07. Baseline demographic characteristics, clinical, radiologic and endoscopic findings were collected. RESULTS: Totally 103 (34 benign, 69 malignant lesions) patients with SB tumors in 1070 enteroscopic examinations were enrolled...
October 5, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28988501/dermatofibrosarcoma-protuberans-and-gastrointestinal-stromal-tumor-as-models-for-targeted-therapy-in-soft-tissue-sarcomas
#16
Hanna Koseła-Paterczyk, Piotr Rutkowski
The development of novel targeted treatment in soft tissue sarcomas (STS) is important since many sarcoma subtypes are resistant to conventional chemotherapy and effective therapeutic options are limited. Areas covered: This review discusses the molecular background and treatment in two STS types which became a model for targeted therapy - gastrointestinal stromal tumor (GIST) and dermatofibrosarcoma protuberans (DFSP). DFSP is characterized, in the majority of cases, by chromosomal translocation which results in the formation of COL1A1-PDGFB fusion gene causing platelet-derived growth factor receptor beta(PDGFRB) signaling activation in tumor cells...
October 9, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28984483/latest-advances-in-adult-gastrointestinal-stromal-tumors
#17
Vaia Florou, Breelyn A Wilky, Jonathan C Trent
Gastrointestinal stromal tumors (GISTs) are the most common GI tract mesenchymal tumors. GIST patients are optimally managed by a precision medicine approach. Herein, we discuss the latest advances in precision medicine and ongoing clinical trials relevant to GIST. Circulating tumor DNA for detection of mutational changes could replace tissue biopsies and radiographic imaging once validated. Most GISTs are KIT/PDGFRα mutated, and despite the good clinical response to imatinib, treatment is generally not curative, more often due to secondary mutations...
October 6, 2017: Future Oncology
https://www.readbyqxmd.com/read/28979709/laparoscopic-resection-of-gastrointestinal-stromal-tumors-does-laparoscopic-surgery-provide-an-adequate-oncologic-resection
#18
REVIEW
Joseph J Kim, James Y Lim, Scott Q Nguyen
Gastrointestinal stromal tumors (GISTs) are rare tumors of the GI tract. Surgical resection remains the mainstay of non-metastatic disease. However, the ability to provide an adequate oncologic resection using laparoscopic surgery is still an area of debate. This is a thorough review of the current literature, looking particularly at the use of laparoscopic surgery for larger GISTs and the long-term oncologic outcomes compared to the results of open surgery. Laparoscopic resections provide an adequate oncologic result for GISTs of all sizes, including those greater than 5 cm in size...
September 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28976120/tumor-molecular-profiling-in-the-treatment-of-refractory-cancers-%C3%A2
#19
Birendra Kc, Muhammad Zubair Afzal, Andrew Sochaki, Katherine A Wentland, Rubens Chang, Sudhir Singh, Timothy O'Rourke
INTRODUCTION: Molecular profiling (MP) has been used as a technique to identify treatment regimens for individual patient's cancer. The results of MP has been used to guide targeted therapy specific to each patient's tumor that resulted in a longer progression free survival (PFS) compared to the last conventional treatment. This study aims to provide further data to delineate the PFS of patients who get treated with targeted therapy based on MP. METHODS: A retrospective chart review was performed...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28975120/metastatic-gastrointestinal-stromal-tumor-a-regional-cancer-center-experience-of-44-cases
#20
M C Suresh Babu, Tamojit Chaudhuri, K Govind Babu, K C Lakshmaiah, D Lokanatha, Linu Abraham Jacob, A H Rudresha, K N Lokesh, L K Rajeev
BACKGROUND: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Historically, a poor prognosis for metastatic disease has been reported with systemic chemotherapy. Significant advances have been made in the last decade, since the introduction of different tyrosine kinase inhibitors (TKIs). Unfortunately, even though the TKIs have been used for a long time, there are very few published data of the experience of TKI therapy in metastatic GIST from India...
July 2017: South Asian Journal of Cancer
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