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https://www.readbyqxmd.com/read/29232679/clinicopathological-and-prognostic-features-of-surgical-management-in-duodenal-gastrointestinal-stromal-tumors
#1
Hong Peng Shi, Min Lu Huang, Zhen Qiang Wang, Ya Nan Zheng, Zheng Lun Zhu, Birendra Kumar Sah, Wen Tao Liu, Min Yan, Zheng Gang Zhu, Chen Li
BACKGROUND AND OBJECTIVES: The rarity of duodenal gastrointestinal stromal tumors (DGIST) led to only limited data being available on their management and prognosis. We retrospectively analyzed the clinicopathological features, surgical treatments, adjuvant therapy, and prognosis of DGIST. METHODS: Sixty-one patients were identified at diagnosis of primary DGIST from February 2005 to December 2015. One hundred twenty six patients with small intestinal gastrointestinal stromal tutors (GIST) were selected as control groups...
December 12, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/29232272/relative-effects-of-age-race-and-stage-on-mortality-in-gestational-choriocarcinoma
#2
Christopher M Tarney, Chunqiao Tian, Eric R Craig, Barbara A Crothers, John K Chan, Glenn D Gist, Nicholas W Bateman, Thomas P Conrads, Chad A Hamilton, George Larry Maxwell, Kathleen M Darcy
OBJECTIVE: Gestational choriocarcinoma is a malignant form of gestational trophoblastic disease that usually arises after a molar pregnancy, but may follow any antecedent pregnancy. Investigations in this rare cancer are limited. We evaluated the prognostic effects of age, race, and stage in choriocarcinomas diagnosed for 4 decades. METHODS: Patients diagnosed as having gestational choriocarcinoma between 1973 and 2014 from the Surveillance, Epidemiology, and End Results program were eligible...
December 11, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29227120/-molecular-mechanisms-of-primary-and-secondary-resistance-molecular-genetic-features-and-characteristics-of-kit-pdgfra-non-mutated-gists
#3
Alena Kalfusová, Roman Kodet
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Most of them arise due to activating mutations in KIT (75 - 85 %) or PDGFRA (less than 10 %) genes. Identification of the activating mutations in KIT and PDGFRA genes, which code for receptor tyrosine kinases (RTKs), has improved the outcome of targeted therapy of metastatic, unresectable or recurrent GISTs. Primary and/or secondary resistance represents a significant problem in the targeted therapy by Imatinib mesylate (IM) in patients with GIST...
2017: Ceskoslovenská Patologie
https://www.readbyqxmd.com/read/29220298/gastrointestinal-stromal-tumors
#4
Margaret von Mehren, Heikki Joensuu
GI stromal tumors (GISTs) are neoplasms with a varying malignancy potential ranging from virtually indolent tumors to rapidly progressing cancers. GISTs occur throughout the intestinal tract, and most harbor an activating mutation in either KIT or platelet-derived growth factor A ( PDGFRA). Diagnosis is made using immunohistochemistry, but molecular testing with mutation analysis is paramount for selection of appropriate therapy. Most small GISTs are cured with surgery. Tyrosine kinase inhibitor (TKI) therapy has led to substantial improvements in survival, both for patients with localized GIST and those with advanced disease...
December 8, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29218655/a-rare-case-of-a-metastatic-gastrointestinal-stromal-tumor-gist-a-case-report-and-review-of-the-literature
#5
Hamzeh Saraireh, Obada Tayyem, Omar Al Asad, Ranjana Nawgiri, Issam Alawin
No abstract text is available yet for this article.
December 7, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29215507/robotic-gastrotomy-with-intracorporeal-suture-for-patients-with-gastric-gastrointestinal-stromal-tumors-located-at-cardia-and-subcardiac-region
#6
Jian Zhao, Gang Wang, Zhiwei Jiang, Chuanwei Jiang, Jiang Liu, Jiahui Zhou, Jieshou Li
PURPOSE: Few studies of robotic gastric gastrointestinal stromal tumors (GISTs) resection have been conducted. This study was aimed to evaluate the robotic gastrotomy with intracorporeal suture for patients with GISTs located at cardia and subcardiac region. MATERIALS AND METHODS: From January 2014 to August 2016, 11 patients with GISTs located at cardia and subcardiac region underwent robotic gastrotomy with intracorporeal suture. Data of these patients were collected...
December 6, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29210715/blistering-and-skin-fragility-due-to-imatinib-therapy-loss-of-laminin-and-collagen-iv-as-a-possible-cause-of-cutaneous-basement-membrane-instability
#7
Sebastian Mühl, Jan Ehrchen, Dieter Metze
Imatinib mesylate (Glivec; Novartis AG, Basel, Switzerland) is a tyrosine kinase inhibitor which is used in the treatment of oncologic diseases like chronic myeloid leukemia and gastrointestinal stroma tumor (GIST). Among cutaneous side effects, bullous reactions are rare. The authors describe the case of a 66-year-old woman developing blistering and skin fragility on her hands, foot, lower legs, and back after intake of imatinib for treatment of GIST. Biopsy showed vacuolar alteration at the dermoepidermal junction (DEJ) associated with a few lymphocytes and a subepidermal blister...
November 22, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29208328/different-approaches-for-identifying-important-concepts-in-probabilistic-biomedical-text-summarization
#8
Milad Moradi, Nasser Ghadiri
Automatic text summarization tools help users in the biomedical domain to acquire their intended information from various textual resources more efficiently. Some of biomedical text summarization systems put the basis of their sentence selection approach on the frequency of concepts extracted from the input text. However, it seems that exploring other measures rather than the raw frequency for identifying valuable contents within an input document, or considering correlations existing between concepts, may be more useful for this type of summarization...
December 2, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29207963/two-staging-systems-for-gastrointestinal-stromal-tumors-in-the-stomach-which-is-better
#9
Chul Hong Park, Gwang Ha Kim, Bong Eun Lee, Geun Am Song, Do Youn Park, Kyung Un Choi, Dae Hwan Kim, Tae Yong Jeon
BACKGROUND: The prognosis of a gastrointestinal stromal tumor (GIST) is influenced by its anatomic site; however, few studies on the prognosis of gastric GISTs have been reported. The aims of this study were to evaluate long-term prognoses of patients who underwent surgical resection for gastric GISTs and to compare the clinical efficacy of two staging systems: the National Institutes of Health (NIH) consensus criteria and the 7th Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) tumor-node-metastasis (TNM) staging system...
December 6, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29207774/a-diagnostic-surprise-for-a-right-iliac-fossa-mass-a-perforated-ileal-gastrointestinal-stromal-tumour
#10
J Sanjay Prakash, Anita Samraj, G Sabarish Kumar, R Vijai
Gastrointestinal Stromal Tumours (GISTs) are tumours of the gut found mostly in stomach and small intestine. The complications are Gastrointestinal (GI) bleeding, obstruction, pain and rarely perforation. We are reporting an abnormal presentation of GIST masquerading as an acute abdomen with Right Iliac Fossa (RIF) mass in 60-year-old lady. Contrast Enhanced Computed Tomography (CECT) of abdomen revealed a peripherally enhancing encapsulated abscess in RIF in close contact with base of caecum and adjacent peritonitis suggesting caecal perforation...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29206199/a-novel-receptor-tyrosine-kinase-switch-promotes-gastrointestinal-stromal-tumor-drug-resistance
#11
Sergei Boichuk, Aigul Galembikova, Pavel Dunaev, Elena Valeeva, Elena Shagimardanova, Oleg Gusev, Svetlana Khaiboullina
The fact that most gastrointestinal stromal tumors (GISTs) acquire resistance to imatinib (IM)-based targeted therapy remains the main driving force to identify novel molecular targets that are capable to increase GISTs sensitivity to the current therapeutic regimens. Secondary resistance to IM in GISTs typically occurs due to several mechanisms that include hemi- or homo-zygous deletion of the wild-type KIT allele, overexpression of focal adhesion kinase (FAK) and insulin-like growth factor receptor I (IGF-1R) amplification, BRAF mutation, a RTK switch (loss of c-KIT and gain of c-MET/AXL), etc...
December 5, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29204252/paradoxical-expression-pattern-of-the-epithelial-mesenchymal-transition-related-biomarkers-cd44-slug-n-cadherin-and-vsig1-glycoprotein-a34-in-gastrointestinal-stromal-tumors
#12
Attila Kövecsi, Simona Gurzu, Zoltan Szentirmay, Zsolt Kovacs, Tivadar Jr Bara, Ioan Jung
AIM: To evaluate the immunohistochemical (IHC) expression of five biomarkers, commonly involved in epithelial mesenchymal/mesenchymal epithelial transition (EMT/MET), in gastrointestinal stromal tumors (GISTs). METHODS: In 80 consecutive GISTs the IHC examinations were performed using the EMT-related antibodies E-cadherin, N-cadherin, SLUG, V-set and immunoglobulin domain containing 1 (VSIG1) and CD44. RESULTS: The positivity rate was 88.75% for SLUG, 83...
November 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29203825/adjuvant-imatinib-for-patients-with-high-risk-gastrointestinal-stromal-tumors-a-retrospective-cohort-study
#13
Rui Zhao, Yong Wang, Yuqian Huang, Yaping Cui, Lin Xia, Yi Chen, Wen Zhuang, Yong Zhou, Xiaoting Wu
The duration of adjuvant imatinib for high-risk patients with gastrointestinal stromal tumors (GISTs) is still controversial. Therefore, we retrospectively analyzed the data of high-risk patients with GISTs to investigate the appropriate duration. All 185 patients were divided into 4 groups: <1 year (Group A), 1-2 years (Group B), 2-3 years (Group C) and >3 years (Group D). The mean recurrence-free survival (RFS) in Groups A, B, and C were 44.3, 62.1, and 86.8 months, respectively (P < 0.001); the mean overall survival (OS) in Groups A, B and C was 75...
December 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29203083/effect-of-different-formats-for-information-on-side-effects-regarding-medicine-users-understanding-a-randomized-controlled-trial
#14
Cassia Garcia Moraes, Tatiane da Silva Dal Pizzol
OBJECTIVE: The objective of this randomized controlled trial was to evaluate the efficacy of presenting information on the risks of side effects from a medicine, presented in different formats. METHODS: A randomized, parallel-group, single-center controlled trial was conducted among adult users of a training pharmacy. The information was categorized into the following groups: verbal descriptors+percentage range, percentage range and absolute percentage. The main outcomes were gist understanding and verbatim understanding, classified either as adequate or inadequate...
November 26, 2017: Patient Education and Counseling
https://www.readbyqxmd.com/read/29200317/pediatric-gist-presenting-as-anemia
#15
Paola Cianci, Chiara Luini, Maddalena Marinoni, Luigi Nespoli, Alessandro Salvatoni, Silvia Salvatore
Gastrointestinal stromal tumors (GIST) are tumors of the gastrointestinal (GI) tract originating from the myenteric ganglion cells (interstitial cells of Cajal), that are very rare in children and adolescents. The most common clinical manifestation is acute or chronic, overt or occult GI bleeding although these tumors are asymptomatic in 10-30% of patients. We report a case of gastric GIST in a 11-year-old girl presenting with an iron deficiency refractory anemia without gastrointestinal symptoms and stool evidence of GI bleeding that caused a slight diagnostic delay...
December 4, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/29196126/oncogenic-kit-signalling-on-the-golgi-is-suppressed-by-blocking-secretory-trafficking-with-m-copa-in-gastrointestinal-stromal-tumours
#16
Yuuki Obata, Keita Horikawa, Isamu Shiina, Tsuyoshi Takahashi, Takatsugu Murata, Yasutaka Tasaki, Kyohei Suzuki, Keita Yonekura, Hiroyasu Esumi, Toshirou Nishida, Ryo Abe
Most gastrointestinal stromal tumours (GISTs) are caused by constitutively active mutations in Kit tyrosine kinase. The drug imatinib, a specific Kit inhibitor, improves the prognosis of metastatic GIST patients, but these patients become resistant to the drug by acquiring secondary mutations in the Kit kinase domain. We recently reported that a Kit mutant causes oncogenic signals only on the Golgi apparatus in GISTs. In this study, we show that in GIST, 2-methylcoprophilinamide (M-COPA, also known as "AMF-26"), an inhibitor of biosynthetic protein trafficking from the endoplasmic reticulum (ER) to the Golgi, suppresses Kit autophosphorylation at Y703/Y721/Y730/Y936, resulting in blockade of oncogenic signalling...
November 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29192406/gastric-gastrointestinal-stromal-tumors-gist-a-case-series-and-current-state-of-the-art-in-the-workup-and-treatment-of-this-rare-disease
#17
Neil R Sharma, Harishankar Gopakumar, Scott Harrison, Natalie Ehmke, Christina Zelt
No abstract text is available yet for this article.
December 1, 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/29190526/the-influence-of-perceptual-similarity-and-individual-differences-on-false-memories-in-aging
#18
Nancy A Dennis, Indira C Turney
Previous false memory research has suggested that older adults' false memories are based on an overreliance on gist processing in the absence of item-specific details. Yet, false memory studies have rarely taken into consideration the precise role of item-item similarity on the cognitive and neural mechanisms underlying perceptual false memories in older adults. In addition, work in our laboratory has suggested that when investigating the neural basis of false memories in older adults, it is equally as critical to take into account interindividual variability in behavior...
November 1, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/29188154/somatostatin-receptor-avidity-in-gastrointestinal-stromal-tumors-theranostic-implications-of-gallium-68-scan-and-eligibility-for-peptide-receptor-radionuclide-therapy
#19
Arturo Loaiza-Bonilla, Paula A Bonilla-Reyes
This manuscript reports on a patient with a metastatic gastrointestinal stromal tumor (GIST) refractory to standard first-line treatment, who underwent a gallium-68 scan based on pre-clinical data of somatostatin receptor (SSTR) expression in such tumors. The gallium-68 DOTATATE scan determined significant somatostatin receptor avidity as hypothesized, suggesting that this imaging modality may be used as an option for diagnostic and follow-up purposes in GIST patients. In addition, peptide receptor-mediated radiotherapy (177Lu-PPRT) via SSTR may provide a novel treatment strategy in carefully selected SSTR-avid GIST patients with thyrosine kinase inhibitor (TKI)-resistant tumors such as this case, and this warrants further investigation in novel clinical trial concepts...
September 24, 2017: Curēus
https://www.readbyqxmd.com/read/29187943/-rare-digestive-tumors-gastrointestinal-stromal-tumors-gists-about-a-case-of-small-bowel-location-and-literature-review
#20
Habib Bellamlih, Lamiae Bouimetarhan, Touriya Amil, Hassan En-Nouali, Naoufal Chouaib, Said Jidane, Mostafa Rafai, Ahmed Belkouch, Lahcen Belyamani
Gastrointestinal stromal tumors (GISTs) are a rare group of mesenchymal tumors mainly occurring in the gastrointestinal tract. Previously, GISTs were classified as smooth muscle tumors also known as leiomyomas, leiomyosarcomas or leiomyoblastomas. However, since the advent of immunohistochemistry, GISTs have been diagnosed on the basis of the identification of c-kit-positive cells. We here report a case of stromal tumor of the small intestine in order to analyze it in the light of literature data and imaging results, which may suggest prebiopsy diagnosis as well as its therapeutic and prognostic peculiarities...
2017: Pan African Medical Journal
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