keyword
MENU ▼
Read by QxMD icon Read
search

GIST

keyword
https://www.readbyqxmd.com/read/28820749/surgical-pathology-of-gastrointestinal-stromal-tumors-practical-implications-of-morphologic-and-molecular-heterogeneity-for-precision-medicine
#1
Gregory W Charville, Teri A Longacre
Gastrointestinal stromal tumor (GIST), the most common mesenchymal neoplasm of the gastrointestinal tract, exhibits diverse histologic and clinical manifestations. With its putative origin in the gastrointestinal pacemaker cell of Cajal, GIST can arise in association with any portion of the tubular gastrointestinal tract. Morphologically, GISTs are classified as spindled or epithelioid, though each of these subtypes encompasses a broad spectrum of microscopic appearances, many of which mimic other histologic entities...
August 17, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28808875/ssat-state-of-the-art-conference-current-surgical-management-of-gastric-tumors
#2
Jeffrey A Norton, Teresa Kim, Joseph Kim, Martin D McCarter, Kaitlyn J Kelly, Joyce Wong, Jason K Sicklick
INTRODUCTION: The current era of gastric surgery is marked by low morbidity and mortality rates, innovative strategies to approach resections with a minimally invasive fashion or hyperthermic intraperitoneal chemotherapy (HIPEC), as well as improved understanding of the biology of sporadic and hereditary stromal, neuroendocrine, and epithelial malignancies. METHODS: In 2017, the Society for Surgery of the Alimentary Tract convened a State-of-the-Art Conference on Current Surgical Management of Gastric Tumors with both international experts and emerging leaders in the field of gastric surgery...
August 14, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28808356/the-gist-of-delay-of-gratification-understanding-and-predicting-problem-behaviors
#3
Valerie F Reyna, Evan A Wilhelms
Delay of gratification captures elements of temptation and self-denial that characterize real-life problems with money and other problem behaviors such as unhealthy risk taking. According to fuzzy-trace theory, decision makers mentally represent social values such as delay of gratification in a coarse but meaningful form of memory called "gist." Applying this theory, we developed a gist measure of delay of gratification that does not involve quantitative trade-offs (as delay discounting does) and hypothesize that this construct explains unique variance beyond sensation seeking and inhibition in accounting for problem behaviors...
April 2017: Journal of Behavioral Decision Making
https://www.readbyqxmd.com/read/28806955/reducing-the-socioeconomic-gradient-in-uptake-of-the-nhs-bowel-cancer-screening-programme-using-a-simplified-supplementary-information-leaflet-a-cluster-randomised-trial
#4
Samuel G Smith, Jane Wardle, Wendy Atkin, Rosalind Raine, Lesley M McGregor, Gemma Vart, Steve Morris, Stephen W Duffy, Susan Moss, Allan Hackshaw, Stephen Halloran, Ines Kralj-Hans, Rosemary Howe, Julia Snowball, Graham Handley, Richard F Logan, Sandra Rainbow, Steve Smith, Mary Thomas, Nicholas Counsell, Christian von Wagner
BACKGROUND: Uptake of colorectal cancer screening is low in the English NHS Bowel Cancer Screening Programme (BCSP). Participation in screening is strongly associated with socioeconomic status. The aim of this study was to determine whether a supplementary leaflet providing the 'gist' of guaiac-based Faecal Occult Blood test (gFOBt) screening for colorectal cancer could reduce the socioeconomic status (SES) gradient in uptake in the English NHS BCSP. METHODS: The trial was integrated within routine BCSP operations in November 2012...
August 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28803766/different-neural-routes-to-autobiographical-memory-recall-in-healthy-people-and-individuals-with-left-medial-temporal-lobe-epilepsy
#5
Cornelia McCormick, Morris Moscovitch, Taufik A Valiante, Melanie Cohn, Mary Pat McAndrews
Individuals with medial temporal lobe epilepsy (mTLE) are poor at recalling vivid details from autobiographical memories (AM), instead retrieving gist-like schematic memories. Recent research has suggested that this impoverished recall in comparison to controls may reflect (1) differential engagement of anterior vs posterior regions of the hippocampus (HC) and/or (2) differences between the engagement of the HC vs the ventromedial prefrontal cortex (vmPFC). Here we examined these hypotheses by comparing connectivity amongst hippocampal regions and between vmPFC and other brain regions during construction (retrieval of a particular event) vs elaboration (retrieval of perceptual detail) phases of AM recall in 12 individuals with left mTLE and 12 matched controls...
August 10, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28799152/-gastric-schwannoma-rare-differenzial-diagnosis-of-acute-upper-gastrointestinal-gi-bleeding
#6
Orestis Lyros, Stephan Schickel, Katrin Schierle, Albrecht Hoffmeister, Ines Gockel
Schwannomas are benign tumors derived from Schwann cells and their typical site of origin is the subcutaneous tissue of the extremities. Gastrointestinal localization of Schwannomas is extremely rare and the stomach is the prevalent site. Gastric schwannomas primarily occur in the gastric submucosa and are usually asymptomatic.We present a rare case of a solitary gastric schwannoma in a 51-year old male, which initially manifested with hematemesis by acute upper gastrointestinal (GI) bleeding. The upper GI-Endoscopy revealed a gastric submucosal tumor, 7 cm in size, located in the proximal corpus and fundus...
August 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28798000/epidemiology-and-survival-analysis-of-gastrointestinal-stromal-tumors-in-lebanon-real-life-study-from-a-hospital-tumor-registry-2000-2015
#7
Elie El Rassy, Fadi Nasr, Tarek Assi, Toni Ibrahim, Nathalie Rassy, Joseph Bou Jaoude, Marcel Massoud, Georges Chahine
BACKGROUND: We report, to our knowledge, one of the largest studies concerning gastrointestinal stromal tumors (GIST) in the Middle East. We also present a survival analysis of GIST in our 15-year real-life experience. METHODS: We studied demographic, epidemiologic and survival characteristics of 70 patients with confirmed GIST in a cross-sectional study between 2000 and 2015. RESULTS: The median age of our patients was 62 ±12.8 years (range, 25-84) with a male to female ratio of 1...
May 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/28796048/clinicopathologic-study-of-succinate-dehydrogenase-deficient-gastrointestinal-stromal-tumors-a-single-institutional-experience-in-china
#8
Weizhen Liu, Xiangyu Zeng, Xiuli Wu, Jun He, Jinbo Gao, Xiaoming Shuai, Guobin Wang, Peng Zhang, Kaixiong Tao
Gastrointestinal stromal tumors (GISTs) that are not driven by kinase mutations, as are most GISTs, often show loss of function of the succinate dehydrogenase (SDH) complex and are considered SDH-deficient GISTs. SDH-deficient GISTs share many distinct characteristics compared with conventional GISTs. However, data regarding these characteristics, particularly among Asian people, are relatively limited. The objective of this study was to characterize the clinicopathologic characteristics, treatment, and prognosis of these uncommon GISTs...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28795834/contrasting-gist-based-and-template-based-guidance-during-real-world-visual-search
#9
Brett Bahle, Michi Matsukura, Andrew Hollingworth
Visual search through real-world scenes is guided both by a representation of target features and by knowledge of the sematic properties of the scene (derived from scene gist recognition). In 3 experiments, we compared the relative roles of these 2 sources of guidance. Participants searched for a target object in the presence of a critical distractor object. The color of the critical distractor either matched or mismatched (a) the color of an item maintained in visual working memory for a secondary task (Experiment 1), or (b) the color of the target, cued by a picture before search commenced (Experiments 2 and 3)...
August 10, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28791999/-clinical-and-morphological-characteristics-of-gastrointestinal-stromal-tumors
#10
D D Khalikov, F Sh Akhmetzyanov, S V Petrov
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. Despite this, GISTS comprise about 2% in the structure of digestive tract cancers. They are usually localized in the stomach; however, they can be found in the small intestine and more rarely in the colon and esophagus. Although approximately 70% of the GISTs consist predominantly of spindle cells; the epithelioid cell tumors represent 20% of cases; there are also mixed variants. This variability in the morphological structure of GISTs complicates their diagnosis...
2017: Arkhiv Patologii
https://www.readbyqxmd.com/read/28786245/hyperechoic-demarcation-line-between-a-tumor-and-the-muscularis-propria-layer-as-a-marker-for-deciding-the-endoscopic-treatment-of-gastric-submucosal-tumor
#11
Yu Zhang, Zhen Wang, Ting Jin, Kai-Qiang Li, Ke Hao, Wei Zhang, Bao-Ying Fei
Minimally invasive endoscopic resection has been rapidly adopted as a new technique for treating patients with gastric submucosal tumors (SMTs) originating in the muscularis propria (MP) layer. This study was conducted to evaluate the information obtained from endoscopic ultrasonography (EUS) to determine the appropriate endoscopic dissection method for treating SMTs originating in the MP layer. Between February 2014 and May 2016, a total of 50 patients with gastric SMTs originating in the MP layer were enrolled in this study...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28785140/current-research-and-treatment-for-gastrointestinal-stromal-tumors
#12
EDITORIAL
Kheng Tian Lim, Kok Yang Tan
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and have gained considerable research and treatment interest, especially in the last two decades. GISTs are driven by mutations commonly found in the KIT gene and less commonly in the platelet-derived growth factor receptor alpha gene, BRAF gene and succinate dehydrogenase gene. GISTs behave in a spectrum of malignant potential, and both the tumor size and mitotic index are the most commonly used prognostic criteria...
July 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28784793/stress-promotes-generalization-of-older-but-not-recent-threat-memories
#13
Joseph E Dunsmoor, A Ross Otto, Elizabeth A Phelps
Stress broadly affects the ability to regulate emotions and may contribute to generalization of threat-related behaviors to harmless stimuli. Behavioral generalization also tends to increase over time as memory precision for recent events gives way to more gist-like representations. Thus, acute stress coupled with a delay in time from a negative experience may be a strong predictor of the transition from normal to generalized fear expression. Here, we investigated the effect of a single-episode acute stressor on generalization of aversive learning when stress is administered either immediately after an aversive learning event or following a delay...
August 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28783738/improvement-to-ultrasonographical-differential-diagnosis-of-gastric-lesions-the-value-of-contrast-enhanced-sonography-with-gastric-distention
#14
Tingting Li, Man Lu, Jun Song, Ping Wu, Xueqing Cheng, Zhenqi Zhang
OBJECTIVE: The purpose of this retrospective study is to evaluate the diagnostic value of contrast enhanced sonography plus gastric distention sonography, the Double Contrast-enhanced Ultrasound (DCUS) in gastric lesions. METHODS: 107 cases with pathology confirmed gastric lesions were retrospectively reviewed, DCUS and oral contrast agent ultrasound (US) were performed in all cases prior to operation. Perfusion parameters including arrival time (AT), peak intensity (PI), time to peak (TTP), and area under the curve (AUC) of the lesion and surrounding normal tissue were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28782509/subepithelial-esophageal-tumors-a-single-center-review-of-resected-and-surveilled-lesions
#15
Don C Codipilly, Hongfei Fang, Jeffrey A Alexander, David A Katzka, Karthik Ravi
BACKGROUND AND AIMS: Subepithelial esophageal tumors (SETs) are frequent incidental findings. Although symptomatic tumors are surgically or endoscopically resected, there is no consensus on the management of asymptomatic esophageal leiomyomas. METHODS: Appropriate ICD-9 codes followed by medical record review were used to identify patients with SETs from January 1992 to March 2017, with abstraction of basic demographics, surveillance intervals, and mortality. Patients were contacted to complete a phone questionnaire to assess follow-up and complete the validated brief esophageal dysphagia questionnaire (BEDQ)...
August 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28779248/laparoscopic-resection-for-gastrointestinal-stromal-tumors-in-esophagogastric-junction-egj-how-to-protect-the-egj
#16
Wenjun Xiong, Jiaming Zhu, Yansheng Zheng, Lijie Luo, Yaobin He, Hongming Li, Dechang Diao, Liaonan Zou, Jin Wan, Wei Wang
BACKGROUND: Laparoscopic surgery for gastric gastrointestinal stromal tumors (GISTs) is now widely performed. However, laparoscopic resection of GIST in the esophagogastric junction (EGJ) is technically difficult and rarely reported. Herein, we introduce four fashions of laparoscopic resection for EGJ-GIST. METHODS: A retrospective review of 42 consecutive patients with EGJ-GIST who underwent attempted laparoscopic surgery was conducted. EGJ-GIST was defined as GIST with an upper border of less than 5 cm from the esophagogastric line...
August 4, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28777995/beyond-stereotypes-of-adolescent-risk-taking-placing-the-adolescent-brain-in-developmental-context
#17
REVIEW
Daniel Romer, Valerie F Reyna, Theodore D Satterthwaite
Recent neuroscience models of adolescent brain development attribute the morbidity and mortality of this period to structural and functional imbalances between more fully developed limbic regions that subserve reward and emotion as opposed to those that enable cognitive control. We challenge this interpretation of adolescent development by distinguishing risk-taking that peaks during adolescence (sensation seeking and impulsive action) from risk taking that declines monotonically from childhood to adulthood (impulsive choice and other decisions under known risk)...
July 26, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28777148/new-mechanisms-of-mtor-pathway-activation-in-kit-mutant-malignant-gists
#18
Jerzy Lasota, Artur Kowalik, Anna Felisiak-Golabek, Sebastian Zięba, Zeng-Feng Wang, Markku Miettinen
A great majority of gastrointestinal stromal tumors (GISTs) are primarily driven by gain-of-function KIT receptor tyrosine kinase mutations that subsequently lead to activation of phosphatidiylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) pathway, a downstream effector of KIT signaling. KIT tyrosine kinase inhibitor, imatinib mesylate, has been successfully used for the treatment of primary, advanced, and disseminated GISTs. Recently, activation of mTOR pathway independent of KIT signaling was demonstrated in imatinib mesylate naïve malignant GISTs and treatment-resistant metastatic tumors...
August 2, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28774719/defective-methionine-metabolism-in-the-brain-after-repeated-blast-exposures-might-contribute-to-increased-oxidative-stress
#19
Peethambaran Arun, William B Rittase, Donna M Wilder, Ying Wang, Irene D Gist, Joseph B Long
Blast-induced traumatic brain injury (bTBI) is one of the major disabilities in Service Members returning from recent military operations. The neurobiological underpinnings of bTBI, which are associated with acute and chronic neuropathological and neurobehavioral deficits, are uncertain. Increased oxidative stress in the brain is reported to play a significant role promoting neuronal damage associated with both brain injury and neurodegenerative disorders. In this study, brains of rats exposed to repeated blasts in a shock tube underwent untargeted profiling of primary metabolism by automatic linear exchange/cold injection GC-TOF mass spectrometry and revealed acute and sub-acute disruptions in the metabolism of the essential amino acid methionine and associated antioxidants...
July 31, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28768491/succinate-dehydrogenase-deficiency-in-a-pdgfra-mutated-gist
#20
Martin G Belinsky, Kathy Q Cai, Yan Zhou, Biao Luo, Jianming Pei, Lori Rink, Margaret von Mehren
BACKGROUND: Most gastrointestinal stromal tumors (GISTs) harbor mutually exclusive gain of function mutations in the receptor tyrosine kinase (RTK) KIT (70-80%) or in the related receptor PDGFRA (~10%). These GISTs generally respond well to therapy with the RTK inhibitor imatinib mesylate (IM), although initial response is genotype-dependent. An alternate mechanism leading to GIST oncogenesis is deficiency in the succinate dehydrogenase (SDH) enzyme complex resulting from genetic or epigenetic inactivation of one of the four SDH subunit genes (SDHA, SDHB, SDHC, SDHD, collectively referred to as SDHX)...
August 2, 2017: BMC Cancer
keyword
keyword
109
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"