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REVIEW
Danish Ali Ashraf, Usman Ahmed, Zainab Zaib Khan, Fiza Mushtaq, Shehar Bano, Ali Raza Khan, Saad Azam, Abdullah Haroon, Salman Ahmed Malik, Raza Aslam, Jai Kumar, Farva Zaib Khan, Amna Faheem, Sarwan Kumar, Saad Hassan
Background: In this study, we aim to discuss the long-term clinical outcomes of intravascular ultrasound imaging-guided percutaneous intervention (IVUS-PCI) versus angiography-guided percutaneous coronary intervention (PCI) in complex coronary lesions over a mean period of 2 years. Methods: A systematic search and meta-analysis were conducted to assess the efficacy of using intravascular ultrasound or optical coherence tomography guidance in coronary artery stenting compared to angiography. Results: A total of 11 randomized controlled trials with 6740 patients were included...
April 16, 2024: Future Cardiology
#2
REVIEW
Doha El-Sayed Ellakwa, Nadia Mushtaq, Sahrish Khan, Abdul Jabbar, Mohamed Ahmed Abdelmalek, Al-Hassan Soliman Wadan, Takwa E Ellakwa, Ali Raza
MiRNAs (microRNAs) constitute a group of diminutive molecules of non-coding RNA intricately involved in regulating gene expression. This regulation is primarily accomplished through the binding of miRNAs to complementary sequences situated in the 3'-UTR of the messenger RNA (mRNA) target; as a result, they are degraded or repressed. The multifaceted biogenesis of miRNAs is characterized by a meticulously orchestrated sequence of events encompassing transcription, processing, transportation, and decay. Colorectal cancer stands as a pervasive and formidable ailment, afflicting millions across the globe...
April 15, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
#3
REVIEW
Muhammad Shahzad Rafiq, Muhammad AbuBakar Shabbir, Ahmed Raza, Shoaib Irshad, Andleeb Asghar, Muhammad Kashif Maan, Mushtaq Ahmed Gondal, Haihong Hao
Antimicrobial resistance (AMR) can potentially harm global public health. Horizontal gene transfer (HGT), which speeds up the emergence of AMR and increases the burden of drug resistance in mobile genetic elements (MGEs), is the primary method by which AMR genes are transferred across bacterial pathogens. New approaches are urgently needed to halt the spread of bacterial diseases and antibiotic resistance. Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), an RNA-guided adaptive immune system, protects prokaryotes from foreign DNA like plasmids and phages...
April 11, 2024: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
#4
JOURNAL ARTICLE
Bushra Syed Imtiyaz, Mushtaq Ahmad Margoob, Fazle Roub Mbbs, Mehwish Imtiaz
OBJECTIVE: Current literature on coronavirus disease 2019 (COVID-19) research presents gaps and opportunities to investigate the psychological experiences of healthcare workers (HCWs) serving in mass trauma situations. We aimed to measure perceived stress, burnout, and resilience in Kashmiri HCWs and explore the relationship of burnout with sociodemographic, work-related, and pandemic-related factors. DESIGN, SETTING, AND PARTICIPANTS: This was a cross-sectional descriptive study...
January 2024: American Journal of Disaster Medicine
#5
Robert Myers, Bakhtawar Mushtaq, Robert Jubelirer, Orlando Kirton
Thyrocervical trunk pseudoaneurysms are a rare entity among pseudoaneurysms, mostly caused by trauma. We present the case of a 74-year-old male who suffered a traumatic pseudoaneurysm of the supra-scapular artery after a rib and scapular fracture. The patient was treated with various interventions along the treatment algorithm, including ultrasound-guided thrombin injection, coil embolization, and surgical excision. In our patient, the pseudoaneurysm was successfully treated with coil embolization, but a persistent thrombosed pseudoaneurysm caused the patient discomfort, prompting the eventual surgical removal...
March 2024: Curēus
#6
REVIEW
Aman Goyal, Laveeza Fatima, Fiza Mushtaq, Muhammad Daoud Tariq, Aemen Kamran, Amir Humza Sohail, Zainali Chunawala, Samia Aziz Sulaiman, Abhigan Babu Shrestha, Abu Baker Sheikh, Agastya D Belur
Endovascular aortic repair is an emerging novel intervention for the management of abdominal aortic aneurysms. It is crucial to compare the effectiveness of different access sites, such as transfemoral access (TFA) and upper extremity access (UEA). An electronic literature search was conducted using PubMed, EMBASE, and Google Scholar databases. The primary endpoint was the incidence of stroke/transient ischemic attack (TIA), while the secondary endpoints included technical success, access-site complications, mortality, myocardial infarction (MI), spinal cord ischemia, among others...
April 8, 2024: Catheterization and Cardiovascular Interventions
#7
JOURNAL ARTICLE
Patrick W Serruys, Shigetaka Kageyama, Giulio Pompilio, Daniele Andreini, Gianluca Pontone, Saima Mushtaq, Mark La Meir, Johan De Mey, Kaoru Tanaka, Torsten Doenst, Ulf Teichgräber, Ulrich Schneider, John D Puskas, Jagat Narula, Himanshu Gupta, Vikram Agarwal, Jonathon Leipsic, Shinichiro Masuda, Nozomi Kotoku, Tsung-Ying Tsai, Scot Garg, Marie-Angele Morel, Yoshinobu Onuma
BACKGROUND AND AIMS: In patients with three-vessel disease and/or left main disease, selecting revascularization strategy based on coronary computed tomography angiography (CCTA) has a high level of virtual agreement with treatment decisions based on invasive coronary angiography (ICA). METHODS: In this study, coronary artery bypass grafting (CABG) procedures were planned based on CCTA without knowledge of ICA. The CABG strategy was recommended by a central core laboratory assessing the anatomy and functionality of the coronary circulation...
April 7, 2024: European Heart Journal
#8
JOURNAL ARTICLE
Vivekananda M Byrareddy, Jarrod Kath, Louis Kouadio, Shahbaz Mushtaq, Vellingiri Geethalakshmi
Agroforestry is a management strategy for mitigating the negative impacts of climate and adapting to sustainable farming systems. The successful implementation of agroforestry strategies requires that climate risks are appropriately assessed. The spatial scale, a critical determinant influencing climate impact assessments and, subsequently, agroforestry strategies, has been an overlooked dimension in the literature. In this study, climate risk impacts on robusta coffee production were investigated at different spatial scales in coffee-based agroforestry systems across India...
April 5, 2024: Scientific Reports
#9
JOURNAL ARTICLE
Matthew Warburton, Jack Brookes, Mohamed Hasan, Matteo Leonetti, Mehmet Dogar, He Wang, Anthony G Cohn, Faisal Mushtaq, Mark Mon-Williams
Human sensorimotor decision making has a tendency to get 'stuck in a rut', being biased towards selecting a previously implemented action structure (hysteresis). Existing explanations propose this is the consequence of an agent efficiently modifying an existing plan, rather than creating a new plan from scratch. Instead, we propose that hysteresis is an emergent property of a system learning from the consequences of its actions. To examine this, 152 participants moved a cursor to a target on a tablet device while avoiding an obstacle...
April 2024: Royal Society Open Science
#10
JOURNAL ARTICLE
Harris Hassan Qureshi, Rehan Mohsin, Naveed Ahmed Mahar, Riaz Ahmed Laghari, Mushtaq Hussain, Altaf Hashmi
OBJECTIVE: To determine the outcomes of robotic surgeries using the Da Vinci robotic surgical system (DVSS) at Pakistan's largest urological tertiary healthcare system. STUDY DESIGN: Descriptive study. Place and Duration of the Study: Department of Minimally Invasive and Robotic Surgery, Division of Urology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan, from March 2017 to December 2021. METHODOLOGY: Hospital records of patients who underwent robotic urological surgeries were assessed for their outcomes in terms of blood loss, mortality, system malfunction, and conversion to open surgery...
April 2024: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
#11
JOURNAL ARTICLE
Abeera Ahmed, Ahmed Mushtaq, Irfan Ali Mirza, Fatima Sana, Syed Rehan Asghar Naqvi
OBJECTIVE: To develop an effective antimicrobial strategy for the management of chronic osteomyelitis. STUDY DESIGN: Observational study. Place and Duration of the Study: Departments of Microbiology and Orthopaedics, Combined Military Hospital Malir, Karachi, Pakistan, from January 2021 to February 2022. METHODOLOGY: Bone biopsies of 45 enrolled participants were taken for microbiological evaluation. Intravenous antibiotic therapy was begun as per empirical therapy based on the local antibiogram and antibiotic policy...
April 2024: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
#12
JOURNAL ARTICLE
Mohammed Ali A Majrashi, Rahul Dev Bairwan, Rayan Y Mushtaq, H P S Abdul Khalil, Moutaz Y Badr, Mohammed Alissa, C K Abdullah, Barakat A Ali, Waleed Y Rizg, Khaled M Hosny
This study investigates the potential of utilizing green chemically treated spent coffee grounds (SCGs) as micro biofiller reinforcement in Poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV) biopolymer composites. The aim is to assess the impact of varying SCG concentrations (1 %, 3 %, 5 %, and 7 %) on the functional, thermal, mechanical properties and biodegradability of the resulting composites with a PHBV matrix. The samples were produced through melt compounding using a twin-screw extruder and compression molding...
April 2, 2024: International Journal of Biological Macromolecules
#13
JOURNAL ARTICLE
Mir Raihanul Islam, Blake Angell, Nahitun Naher, Bushra Zarin Islam, Mushtaq Husain Khan, Martin McKee, Eleanor Hutchinson, Dina Balabanova, Syed Masud Ahmed
Absenteeism by doctors in public healthcare facilities in rural Bangladesh is a form of chronic rule-breaking and is recognised as a critical problem by the government. We explored the factors underlying this phenomenon from doctors' perspectives. We conducted a facility-based cross-sectional survey in four government hospitals in Dhaka, Bangladesh. Junior doctors with experience in rural postings were interviewed to collect data on socio-demographic characteristics, work and living experience at the rural facilities, and associations with professional and social networks...
2024: PLOS Glob Public Health
#14
JOURNAL ARTICLE
Sadia Babar Baloch, Shahzaib Ali, Jaroslav Bernas, Jan Moudrý, Petr Konvalina, Zain Mushtaq, Yves Theoneste Murindangabo, Eze Festus Onyebuchi, Faryal Babar Baloch, Maqshoof Ahmad, Qudsia Saeed, Adnan Mustafa
Agriculture is vital to human life and economic development even though it may have a detrimental influence on soil quality. Agricultural activities can deteriorate the soil quality, endangers the ecosystem health and functioning, food safety, and human health. To resolve the problem of soil degradation, alternative soil conditioners such as wood ash are being explored for their potential to improve soil-plant systems. This study provides an overview of the production, properties, and effects of wood ash on soil properties, crop productivity, and environmental remediation...
April 1, 2024: Chemosphere
#15
JOURNAL ARTICLE
Osama Alam, Latif Ullah Khan, Adeel Khan, Saleh H Salmen, Mohammad Javed Ansari, Fizza Mehwish, Mushtaq Ahmad, Qamar U Zaman, Hua-Feng Wang
DNA binding proteins with one finger (Dof) transcription factors are essential for seed development and defence against various biotic and abiotic stresses in plants. Genomic analysis of Dof has not been determined yet in pitaya (Selenicereus undatus). In this study, we have identified 26 Dof gene family members, renamed as HuDof-1 to HuDof-26, and clustered them into seven subfamilies based on conserved motifs, domains, and phylogenetic analysis. The gene pairs of Dof family members were duplicated by segmental duplications that faced purifying selection, as indicated by the Ka/Ks ratio values...
April 4, 2024: Functional Plant Biology: FPB
#16
REVIEW
Moazzam Shahzad, Muhammad Fareed Khalid, Muhammad Kashif Amin, Mohammad Ammad-Ud-Din, Usman Ilyas, Ali H Mushtaq, Atif Butt, Iqra Anwar, Sibgha Gull Chaudhary, Nausheen Ahmed, Leyla Shune, Anurag K Singh, Sunil H Abhyankar, Joseph P McGuirk, Muhammad Umair Mushtaq
This systematic review aimed to evaluate the proportion of primary and secondary endpoints in hematopoietic stem cell transplant (HSCT) phase III randomized clinical trials (RCTs) and analyze their trends in time and study sponsorship status. The Chi-square test and logistic regression analyses were performed using SPSS version 28. A total of 147 HSCT phase III RCTs from 2006 to 2021 reported 197 primary and 600 secondary endpoints. Overall survival (OS, 17 %), progression-free survival (PFS, 15 %), graft versus host disease (GVHD, 8 %), event-free survival (EFS, 8 %), and organ function (8 %) were the most common primary endpoints...
March 22, 2024: Hematology/oncology and Stem Cell Therapy
#17
JOURNAL ARTICLE
Daniele Andreini, Edoardo Conte, Giovanni Monizzi, Blanca Prestini, Angelo Ratti, Marta Belmonte, Eleonora Melotti, Marco Doldi, Davide Marchetti, Matteo Schillaci, Flavia Nicoli, Angelo Mastrangelo, Pasquale Paolisso, Carlo Gigante, Maria Laura Novembre, Andrea Baggiano, Maria Elisabetta Mancini, Andrea Annoni, Alberto Formenti, Francesca Pizzamiglio, Gianluca Pontone, Paolo Zeppilli, Antonio L Bartorelli, Saima Mushtaq
AIMS: Myocardial bridging (MB) is a frequent congenital anomaly of the epicardial coronary arteries commonly considered a benign condition. However, in some cases a complex interplay between anatomical, clinical and physiology factors may lead to adverse events, including sudden cardiac death. Coronary CT angiography (CCTA) emerged as the gold standard noninvasive imaging technique for the evaluation of MB. Aim of the study was to evaluate MB prevalence and anatomical features in a large population of patients who underwent CCTA for suspected CAD and to identify potential anatomical and clinical predictors of adverse cardiac events at long-term follow-up...
March 29, 2024: International Journal of Cardiology
#18
JOURNAL ARTICLE
Rebecca L Mauldin, Rupal Parekh, John P Connolly, Stephen P Mattingly, Aiman Mushtaq, Kayo Fujimoto
OBJECTIVES: Companions (i.e., friends who spend time together) are important for the well-being of older adults. Senior centers in the United States are places for older adults to participate in group activities and form and maintain companionships. However, differences in mobility and transportation may affect the ability of older adults to leverage senior center activities into actual companionships. METHODS: This social network analysis was conducted to characterize the companionship network among members of a senior center in relation to their life-space mobility and transportation resources...
March 30, 2024: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
#19
JOURNAL ARTICLE
Ayse Bahar Ercan, Melyssa Aronson, Nicholas R Fernandez, Yuan Chang, Adrian Levine, Zhihui Amy Liu, Logine Negm, Melissa Edwards, Vanessa Bianchi, Lucie Stengs, Jiil Chung, Abeer Al-Battashi, Agnes Reschke, Alex Lion, Alia Ahmad, Alvaro Lassaletta, Alyssa T Reddy, Amir F Al-Darraji, Amish C Shah, An Van Damme, Anne Bendel, Aqeela Rashid, Ashley S Margol, Bethany L Kelly, Bojana Pencheva, Brandie Heald, Brianna Lemieux-Anglin, Bruce Crooks, Carl Koschmann, Catherine Gilpin, Christopher C Porter, David Gass, David Samuel, David S Ziegler, Deborah T Blumenthal, Dennis John Kuo, Dima Hamideh, Donald Basel, Dong-Anh Khuong-Quang, Duncan Stearns, Enrico Opocher, Fernando Carceller, Hagit Baris Feldman, Helen Toledano, Ira Winer, Isabelle Scheers, Ivana Fedorakova, Jack M Su, Jaime Vengoechea, Jaroslav Sterba, Jeffrey Knipstein, Jordan R Hansford, Julieta Rita Gonzales-Santos, Kanika Bhatia, Kevin J Bielamowicz, Khurram Minhas, Kim E Nichols, Kristina A Cole, Lynette Penney, Magnus Aasved Hjort, Magnus Sabel, Maria Joao Gil-da-Costa, Matthew J Murray, Matthew Miller, Maude L Blundell, Maura Massimino, Maysa Al-Hussaini, Mazin F Al-Jadiry, Melanie A Comito, Michael Osborn, Michael P Link, Michal Zapotocky, Mithra Ghalibafian, Najma Shaheen, Naureen Mushtaq, Nicolas Waespe, Nobuko Hijiya, Noemi Fuentes-Bolanos, Olfat Ahmad, Omar Chamdine, Paromita Roy, Pavel N Pichurin, Per Nyman, Rachel Pearlman, Rebecca C Auer, Reghu K Sukumaran, Rejin Kebudi, Rina Dvir, Robert Raphael, Ronit Elhasid, Rose B McGee, Rose Chami, Ryan Noss, Ryuma Tanaka, Salmo Raskin, Santanu Sen, Scott Lindhorst, Sebastien Perreault, Shani Caspi, Shazia Riaz, Shlomi Constantini, Sophie Albert, Stanley Chaleff, Stefan Bielack, Stefano Chiaravalli, Stuart Louis Cramer, Sumita Roy, Suzanne Cahn, Suzanne Penna, Syed Ahmer Hamid, Tariq Ghafoor, Uzma Imam, Valerie Larouche, Vanan Magimairajan Issai, William D Foulkes, Yi Yen Lee, Paul C Nathan, Yosef E Maruvka, Mary-Louise C Greer, Carol Durno, Adam Shlien, Birgit Ertl-Wagner, Anita Villani, David Malkin, Cynthia Hawkins, Eric Bouffet, Anirban Das, Uri Tabori
BACKGROUND: Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare and aggressive cancer predisposition syndrome. Because a scarcity of data on this condition contributes to management challenges and poor outcomes, we aimed to describe the clinical spectrum, cancer biology, and impact of genetics on patient survival in CMMRD. METHODS: In this cohort study, we collected cross-sectional and longitudinal data on all patients with CMMRD, with no age limits, registered with the International Replication Repair Deficiency Consortium (IRRDC) across more than 50 countries...
March 26, 2024: Lancet Oncology
#20
JOURNAL ARTICLE
Rizwan Qureshi, Azhar Iqbal, Sunitha Siddanna, Ujala Siddeeq, Farah Mushtaq, Bilal Arjumand, Osama Khattak, Saqib Sarfarz, Naif Abdulrahman Naif Aljunaydi, Abdulrahman Muharrab Mohammed Alkhaldi, Mosa Altassan, Esraa Ahmed Attar, Rakhi Issrani, Namdeo Prabhu
Tooth avulsion is a frequently encountered dental emergency. Children are commonly reported group due to frequent sports activities, trauma, accidents and falls. Prompt emergency management is vital for long term success and to avoid morbidity. The study was aimed to assess the understanding of intern dentists about the emergency handling of avulsed teeth cases as mostly they are first responders among health care personnel. In this study a fourteen-item questionnaire with predefined responses was shared as online Google survey form with intern dentists of 5 different dental teaching hospitals of Islamabad, Pakistan...
March 2024: Journal of Clinical Pediatric Dentistry
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