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https://www.readbyqxmd.com/read/29650268/efficacy-and-toxicity-profile-of-carfilzomib-based-regimens-for-treatment-of-multiple-myeloma-a-systematic-review
#1
REVIEW
Adeela Mushtaq, Vikas Kapoor, Azka Latif, Ahmad Iftikhar, Umar Zahid, Ali McBride, Ivo Abraham, Irbaz Bin Riaz, Faiz Anwer
Standard induction therapy for multiple myeloma is three-drug combination based on following classes of drugs: proteasome inhibitors, immunomodulators and steroids. Despite its notable efficacy, bortezomib has side effects like peripheral neuropathy (PNP) with reported incidence of grade ≥3 PNP between 2%-23% Schlafer et al., 2017. Carfilzomib (CFZ) has high selectivity and minimal off-target adverse effects including lower rates of PNP. CFZ is already approved for treatment of relapsed and refractory multiple myeloma (RRMM) as single agent as well as in combination with lenalidomide and/or dexamethasone...
May 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29625773/asthma-in-the-usa-the-good-the-bad-and-the-disparity
#2
Ammara Mushtaq
No abstract text is available yet for this article.
April 3, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29625273/botany-ethnomedicines-phytochemistry-and-pharmacology-of-himalayan-paeony-paeonia-emodi-royle
#3
REVIEW
Mushtaq Ahmad, Khafsa Malik, Akash Tariq, Guolin Zhang, Ghulam Yaseen, Neelam Rashid, Shazia Sultana, Muhammad Zafar, Kifayat Ullah, Muhammad Pukhtoon Zada Khan
ETHNOPHARMACOLOGICAL RELEVANCE: Himalayan paeony (Paeonia emodi Royle.) is an important species used to treat various diseases. This study aimed to compile the detailed traditional medicinal uses, phytochemistry, pharmacology and toxicological investigations on P. emodi. This study also highlights taxonomic validity, quality of experimental designs and shortcomings in previously reported information on Himalayan paeony. METHODS: The data was extracted from unpublished theses (Pakistan, China, India and Nepal), and different published research articles confined to pharmacology, phytochemistry and antimicrobial activities using different databases through specific keywords...
April 3, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29625159/the-revelation-of-selective-sphingolipid-pathway-inhibition-mechanism-on-fumonisin-toxin-binding-to-ceramide-synthases-in-susceptible-organisms-and-survival-mechanism-in-resistant-species
#4
Shikha Sharma, Mushtaq Ahmed, Yusuf Akhter
Fumonisin B1 toxin (FB1) is a well-known competitive inhibitor of ceramide synthase (CS) in yeast. However, FB1 is unable to obstruct CS from Trichoderma spp., which are well-known biocontrol agents. To explore the contrasting binding modes, a comparative structural analysis of complexes of FB1 with these two CS proteins was carried out. Formation of activation loop on the binding of substrates with the CS from yeast was observed but when inhibitor interacted with the activation loop, it transformed into helix leading to the potentially inactivated state of the enzyme...
April 3, 2018: Biochimie
https://www.readbyqxmd.com/read/29624834/selective-imaging-of-lipids-in-adipocytes-using-an-imidazolyl-derivative-of-perylenebisimide
#5
Jeyaraman Sankar, Ruchika Mishra, Zeeshan Mushtaq, Bhagaban Mallik, Ramprasad Regar, Vimlesh Kumar
A small molecule PBI-ID has been identified and developed as a specific marker for labeling multifunctional fat bodies in various organisms including Drosophila and mammalian adipocytes. Interestingly, PBI-ID neither labels the plasma membranes nor the cell nuclei by trapping into it. A remarkable feature of unbound PBI-ID is the diminished fluorescence, which reduces the background emission noise while contrasting the bound state effectively.
April 6, 2018: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29621888/asthma-knowledge-care-and-outcome-during-pregnancy-the-qakcop-study
#6
Wanis H Ibrahim, Fatima Rasul, Mushtaq Ahmad, Abeer S Bajwa, Laith I Alamlih, Anam M El Arabi, Mujahed M Dauleh, Ibrahim Y Abubeker, Muhammed U Khan, Tayseer S Ibrahim, Azdin A Ibrahim
Asthma is the most common chronic medical condition affecting pregnancy. Optimizing asthma management in pregnancy is paramount for the well-being of both the mother and the baby. The primary objectives of this study were to assess patient's knowledge about asthma, the level of asthma care, and fetal and maternal outcomes among pregnant asthmatic women in this wealthy country with tremendous improvement in maternal and fetal health care. The secondary objective was to identify barriers to asthma control. This was a cross-sectional, face-to-face, prospective study of 80 pregnant women with physician-diagnosed asthma...
January 1, 2018: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/29615046/phytochemical-composition-antilipidemic-and-antihypercholestrolemic-perspectives-of-bael-leaf-extracts
#7
Nosheen Asghar, Zarina Mushtaq, Muhammad Umair Arshad, Muhammad Imran, Rabia Shabir Ahmad, Syed Makhdoom Hussain
BACKGROUND: In recent times, focus on plant research has improved all over the world and essential parts of plants provide bioactive compounds in human diet. The bael (Aegle marmelos) has enormous traditional uses in the treatment of chronic diarrhea, dysentery, peptic ulcers and as a laxative. The main focus of this study was characterization of bael leaf extract for its bioactive constituents, antihypercholestrolemic and antilipidemic perspectives. METHODS: After proximate composition of bael powder, the aqueous extract of bael leaf was used for phytochemical profiling (alkaloids, total phenolic content and total flavonoid content)...
April 3, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29606130/proteasome-inhibitors-modulate-anticancer-and-anti-proliferative-properties-via-nf-kb-signaling-and-ubiquitin-proteasome-pathways-in-cancer-cell-lines-of-different-organs
#8
Asaf A Qureshi, Eleanor G Zuvanich, Dilshad A Khan, Shahida Mushtaq, Neerupma Silswal, Nilofer Qureshi
BACKGROUND: Cancer is second most common cause of death in the United State. There are over 100 different types of cancer associated with different human organs, predominantly breast, liver, pancreas, prostate, colon, rectum, lung, and stomach. We have recently reported properties of pro-inflammatory (for treatment of various types of cancers), and anti-inflammatory (for cardiovascular disease and diabetes) compounds. The major problem associated with development of anticancer drugs is their lack of solubility in aqueous solutions and severe side effects in cancer patients...
April 2, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29605623/copd-and-rural-health-in-the-usa
#9
Ammara Mushtaq
No abstract text is available yet for this article.
March 28, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29604092/prognostic-relevance-of-subclinical-coronary-and-carotid-atherosclerosis-in-a-diabetic-and-non-diabetic-asymptomatic-population
#10
Andrea Igoren Guaricci, Valentina Lorenzoni, Marco Guglielmo, Saima Mushtaq, Giuseppe Muscogiuri, Filippo Cademartiri, Mark Rabbat, Daniele Andreini, Gaetano Serviddio, Nicola Gaibazzi, Mauro Pepi, Gianluca Pontone
BACKGROUD: The aim of the study was to evaluate the incremental prognostic benefit of carotid artery disease and subclinical coronary artery disease (CAD) features in addition to clinical evaluation in a asymptomatic population. METHODS: Over a six-year period, 10-year-FRS together with carotid ultrasound (CUS) and coronary computed tomography angiography (CCTA) were evaluated for the prediction of major adverse cardiac events (MACE). RESULTS: We enrolled 517 consecutive asymptomatic patients (63% male, 64±10 years of age, 17...
March 31, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29602723/impact-of-a-new-adaptive-statistical-iterative-reconstruction-asir-v-algorithm-on-image-quality-in-coronary-computed-tomography-angiography
#11
Gianluca Pontone, Giuseppe Muscogiuri, Daniele Andreini, Andrea I Guaricci, Marco Guglielmo, Andrea Baggiano, Fabio Fazzari, Saima Mushtaq, Edoardo Conte, Andrea Annoni, Alberto Formenti, Elisabetta Mancini, Massimo Verdecchia, Alessandro Campari, Chiara Martini, Marco Gatti, Laura Fusini, Lorenzo Bonfanti, Elisa Consiglio, Mark G Rabbat, Antonio L Bartorelli, Mauro Pepi
RATIONALE AND OBJECTIVES: A new postprocessing algorithm named adaptive statistical iterative reconstruction (ASIR)-V has been recently introduced. The aim of this article was to analyze the impact of ASIR-V algorithm on signal, noise, and image quality of coronary computed tomography angiography. MATERIALS AND METHODS: Fifty consecutive patients underwent clinically indicated coronary computed tomography angiography (Revolution CT; GE Healthcare, Milwaukee, WI)...
March 27, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29600226/assessment-of-quality-of-life-in-resectable-gastric-cancer-patients-undergoing-chemoradiotherapy-as-adjuvant-treatment
#12
Deep Shankar Pruthi, Mushtaq Ahmad, Meenu Gupta, Saurabh Bansal, Vipul Nautiyal, Sunil Saini
Introduction: Quality of life (QOL) is increasingly recognized as an important endpoint in cancer therapies. However, few data are available on QOL in patients who have received radiotherapy as adjuvant treatment for cancer stomach. Methods: Thirty patients who underwent curative resection were enrolled and received chemoradiotherapy (45 Gy in 25 fractions using three-dimensional conformal radiotherapy technique), together with 5-fluorouracil and leucovorin. The European Organization for Research and Treatment of Cancer QOL questionnaire C30 and STO Q22 was assessed at four time points: pre- and postchemoradiotherapy and at 1-month and 6-month follow-up...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29582768/new-clinical-recommendations-for-clostridium-difficile
#13
Ammara Mushtaq
No abstract text is available yet for this article.
April 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29582513/pollen-morphology-of-subfamily-caryophylloideae-caryophyllaceae-and-its-taxonomic-significance
#14
Fazal Ullah, Muhammad Zafar, Mushtaq Ahmad, Shazia Dilbar, Syed Nasar Shah, Aamir Sohail, Wajid Zaman, Majid Iqbal, Siraj Bahadur, Akash Tariq
The Pollen morphology of subfamily Caryophylloideae (Caryophyllaceae) from different phytogeographical region of Pakistan has been evaluated. In this research, 16 species belong to 6 genera of subfamily Caryophylloideae have been studied using light (LM) and scanning electron microscopy (SEM) for both qualitative and quantitative characters. Different palyno-morphological features were observed including; pollen ornamentation, pore ornamentation, echini arrangement, echinidensity, number of pori, size of polar and equatorial diameter, P/E ratio, exine thickness, and size of pore were studied...
March 26, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29580035/fluorescence-in-situ-hybridization-fish-for-differential-diagnosis-of-soft-tissue-sarcomas
#15
Amna Asif, Sajid Mushtaq, Usman Hassan, Noreen Akhtar, Mudassar Hussain, Muhammad Azam, Romena Qazi
Introduction:Soft tissue sarcomas are rare tumors comprising 1 percent of solid malignancies. The latest edition of WHO soft tissue pathology lists 94 benign and malignant soft tissue tumors. Many of these show a large degree of morphological overlap. Immunohistochemistry has been shown to be reliable in many cases for differential diagnosis of lesions, although cytogenetic tests are considered the gold standard for many entities.Fluorescence in-situ hybridization (FISH) is a cytogenetic technique that uses fluorescent probes that bind to only those parts of the chromosome which have a high degree of sequence complementarity...
March 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29569466/heating-effects-of-desi-ghee-using-raman-spectroscopy
#16
Naveed Ahmad, Muhammad Saleem, Mushtaq Ahmed, Shaukat Mahmood
Raman spectroscopy as a fast and nondestructive technique has been used to investigate heating effects on Desi ghee during frying/cooking of food for the first time. A temperature in the range of 140-180℃ has been investigated within which Desi ghee can be used safely for cooking/frying without much alteration of its natural molecular composition. In addition, heating effects in case of reuse, heating for different times, and cooking inside pressure cookers are also presented. An excitation laser at 785 nm has been used to obtain Raman spectra and the range of 540-1800 cm-1 is found to contain prominent spectral bands...
January 1, 2018: Applied Spectroscopy
https://www.readbyqxmd.com/read/29568187/anticonvulsant-and-antioxidant-effects-of-musa-sapientum-stem-extract-on-acute-and-chronic-experimental-models-of-epilepsy
#17
Aditya J Reddy, Ashok Kumar Dubey, Shailendra S Handu, Prashant Sharma, Pramod K Mediratta, Qazi Mushtaq Ahmed, Seema Jain
Background: Musa sapientum (banana) plant extract has been shown to possess antioxidant activity in previous studies. Neuronal injury resulting from oxidative stress is an important factor involved in pathogenesis of epilepsy. Objective: The present study aimed to evaluate the anticonvulsant activity of M. sapientum stem extract (MSSE) in acute and chronic experimental models in mice and its effects on various markers of oxidative stress in the brain of pentylenetetrazole (PTZ)-kindled animals...
January 2018: Pharmacognosy Research
https://www.readbyqxmd.com/read/29566743/electronic-cigarettes-use-and-perception-amongst-medical-students-a-cross-sectional-survey-from-sindh-pakistan
#18
Nousheen Iqbal, Zain A Khan, Syed Muhammad Hamza Anwar, Omar Irfan, Babar Irfan, Ammar Mushtaq, Maria Bibi, Faraz Siddiqui, Javaid A Khan
OBJECTIVE: The manufacturers of electronic cigarettes (e-cigarettes) are actively marketing their product through electronic and social media. Undergraduate medical students are expected to have better knowledge and awareness as they directly interact with patients in their training, The purpose of this study is therefore, to determine knowledge, use and perception regarding e-cigarettes among medical students from Sindh, Pakistan. RESULTS: A cross-sectional study was conducted between 1st July and 30th September 2016 at five different medical colleges situated in the second largest province of Sindh, Pakistan...
March 22, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29558567/operating-list-composition-and-surgical-performance
#19
T W Pike, F Mushtaq, R P Mann, P Chambers, G Hall, J E Tomlinson, R Mir, R M Wilkie, M Mon-Williams, J P A Lodge
BACKGROUND: Recent reviews suggest that the way in which surgeons prepare for a procedure (warm up) can affect performance. Operating lists present a natural experiment to explore this phenomenon. The aim was to use a routinely collected large data set on surgical procedures to understand the relationship between case list order and operative performance. METHOD: Theatre lists involving the 35 procedures performed most frequently by senior surgeons across 38 private hospitals in the UK over 26 months were examined...
March 20, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29551554/retroperitoneoscopic-heminephrectomy
#20
K Taghavi, I Mushtaq
Retroperitoneoscopic heminephrectomy has multiple potential benefits in both infants and children. This article reviewed technical aspects of the procedure, and provided illustrations and an operative video demonstration. The vital first step is a 'critical view' of the collecting system/vascular supply of both upper/lower moieties. Dividing the lateral renal attachments later in the dissection allows passive retraction of the hilum, facilitating this dissection.
March 7, 2018: Journal of Pediatric Urology
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