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https://www.readbyqxmd.com/read/29468499/resveratrol-improves-neuroimmune-dysregulation-through-the-inhibition-of-neuronal-toll-like-receptors-and-cox-2-signaling-in-btbr-t-itpr3-tf-j-mice
#1
Sheikh F Ahmad, Mushtaq A Ansari, Ahmed Nadeem, Mohammad Z Alzahrani, Saleh A Bakheet, Sabry M Attia
Autism is a neurodevelopmental disorder characterized by deficits in qualitative impairments in communication, repetitive and social interaction, restricted, and stereotyped patterns of behavior. Resveratrol has been extensively studied pharmacologically and biologically and has anti-inflammatory, antioxidant, and neuroprotective effects on neuronal damage in neurodegenerative disorders. The BTBR T+ Itpr3tf /J (BTBR) autistic mouse model has been explored for treatment of autism, which shows low reciprocal social interactions, impaired juvenile play, and decreased social approach...
February 21, 2018: Neuromolecular Medicine
https://www.readbyqxmd.com/read/29467005/traditional-knowledge-on-herbal-drinks-among-indigenous-communities-in-azad-jammu-and-kashmir-pakistan
#2
Neelam Rashid, Rodrigue Castro Gbedomon, Mushtaq Ahmad, Valère Kolawolé Salako, Muhammad Zafar, Khafsa Malik
BACKGROUND: Traditional knowledge about the use of medicinal plants for herbal drinks (HDs) is not well documented in the Azad Kashmir region despite their widespread use. This study highlights the taxonomic diversity and traditional knowledge on medicinal plants used for HDs while examining the diversity of diseases treated with HDs in the study area. METHODS: Individual discussions were conducted with 255 informants (84 women and 171 men). Data gathered included (i) informant age and gender, (ii) HD species and respective plant parts used, (iii) health disorders treated, and (iv) mode of preparation and utilizations...
February 21, 2018: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/29458855/streptomyces-puniceus-strain-as13-production-characterization-and-evaluation-of-bioactive-metabolites-a-new-face-of-dinactin-as-an-antitumor-antibiotic
#3
Aehtesham Hussain, Muzafar Ahmad Rather, Mohd Saleem Dar, N A Dangroo, Mushtaq A Aga, Arem Qayum, Aabid Manzoor Shah, Zahoor Ahmad, Mohd Jamal Dar, Qazi Parvaiz Hassan
A highly active actinobacterial strain isolated from untapped areas of Northwestern Himalayas and characterised as Streptomyces puniceus strain AS13 by 16S rRNA gene sequencing was selected for production of bioactive metabolites. The bioassay-guided fractionation of microbial cultured ethyl acetate extract of the strain, led to isolation of macrotetrolide compound 1 (Dinactin) and compound 2 (1-(2,4-dihydroxy-6-methylphenyl)-ethanone). Structures of the isolated compounds were elucidated interpretation of NMR and other spectroscopic data including HR-ESI-MS, FT-IR...
March 2018: Microbiological Research
https://www.readbyqxmd.com/read/29458617/deposition-of-tio%C3%A2-nanoparticles-on-porous-polylactic-acid-fibrous-substrates-and-its-photocatalytic-capability
#4
Xuebin Hou, Yibing Cai, Muhammad Mushtaq, Xiaofei Song, Qiang Yang, Fenglin Huang, Qufu Wei
In this work, porous electrospun polylactic acid (PLA) fibers with high specific surface area and excellent biodegradability were examined as the support of titanium dioxide (TiO2) nanoparticles (NPs). The deposition of TiO2 NPs on porous electrospun PLA fibrous substrates was accomplished through the hydrolysis of titanium tetra isopropoxide (TTIP) under ultrasonic irradiation, and the effects of the TTIP concentrations on structure and property of composite fibers was also investigated. The prepared TiO2-deposited PLA composite fibers were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), High-resolution transmission electron microscopy (HRTEM), Brunauer-Emmett-Teller (BET) and thermogravimetric analyzer (TGA)...
August 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29454774/incremental-diagnostic-value-of-stress-computed-tomography-myocardial-perfusion-with-whole-heart-coverage-ct-scanner-in-intermediate-to-high-risk-symptomatic-patients-suspected-of-coronary-artery-disease
#5
Gianluca Pontone, Daniele Andreini, Andrea I Guaricci, Andrea Baggiano, Fabio Fazzari, Marco Guglielmo, Giuseppe Muscogiuri, Claudio Maria Berzovini, Annalisa Pasquini, Saima Mushtaq, Edoardo Conte, Giuseppe Calligaris, Stefano De Martini, Cristina Ferrari, Stefano Galli, Luca Grancini, Paolo Ravagnani, Giovanni Teruzzi, Daniela Trabattoni, Franco Fabbiocchi, Alessandro Lualdi, Piero Montorsi, Mark G Rabbat, Antonio L Bartorelli, Mauro Pepi
OBJECTIVES: The goal of this study was to evaluate the diagnostic accuracy of stress computed tomography myocardial perfusion (CTP) for the detection of functionally significant coronary artery disease (CAD) by using invasive coronary angiography (ICA) plus invasive fractional flow reserve (FFR) as the reference standard in consecutive intermediate- to high-risk symptomatic patients. BACKGROUND: Stress CTP recently emerged as a potential strategy to combine the anatomic and functional evaluation of CAD in a single scan...
February 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29453670/incidence-and-drug-resistance-of-zoonotic-mycobacterium-bovis-infection-in-peshawar-pakistan
#6
Irfan Khattak, Muhammad Hassan Mushtaq, Sultan Ayaz, Sajid Ali, Anwar Sheed, Javed Muhammad, Muhammad Luqman Sohail, Haq Amanullah, Irshad Ahmad, Sadeeq Ur Rahman
Prevalence of zoonotic Mycobacterium bovis (bTB) disease in human population is underreported from the North of Pakistan. Here, we report on the proportion of human bTB disease among the overall TB patients, drug resistance pattern of bTB isolates, and knowledge, attitude, and practices (KAP)-based analysis of bTB disease. For this purpose, sputum samples from a total of 300 clinically diagnosed TB patients and 100 randomly selected school children suspected of pulmonary TB were processed by culture as well as polymerase chain reaction (PCR) for isolation, identification, and confirmation of Mycobacterium tuberculosis (mTB) and bTB species...
February 17, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29452915/effect-of-male-body-mass-index-on-assisted-reproduction-treatment-outcome-an-updated-systematic-review-and-meta-analysis
#7
REVIEW
Rabia Mushtaq, Jyotsna Pundir, Chiara Achilli, Osama Naji, Yacoub Khalaf, Tarek El-Toukhy
Men with a body mass index (BMI) of 30 or over are more likely to have reduced fertility and fecundity rates. This systematic review and meta-analysis evaluated the effect of male BMI on IVF and intracytoplasmic sperm injection (ICSI) outcome. An electronic search for published literature was conducted in MEDLINE and EMBASE between 1966 and November 2016. Outcome measures were clinical pregnancy rates (CPR) and live birth rates (LBR) per IVF or ICSI cycle. Eleven studies were identified, including 14,372 cycles; nine reported CPR and seven reported LBR...
February 2, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29452882/synthesis-characterisation-and-dna-intercalation-studies-of-regioisomers-of-ruthenium-ii-polypyridyl-complexes
#8
Laura Perdisatt, Samar Moqadasi, Luke O'Neill, Gary Hessman, Alessandra Ghion, Muhammad Qasim Mushtaq Warraich, Alan Casey, Christine O'Connor
Regioisomers of the functional group of the main ligand (L) on a series of [Ru(phen) 2 L] 2+ and [Ru(bpy) 2 L] 2+ complexes, where phen is 1,10 phenanthroline and bpy is 2,2'-bipyridine, were synthesised to investigate the interaction with deoxyribonucleic acid (DNA) as potential therapeutics. UV-Vis binding titrations, thermal denaturation and circular dichroism were used to evaluate their interaction with DNA. The conclusions indicated the significance of the auxiliary ligand; especially 1,10-phenanthroline has on the binding constants (K b )...
February 9, 2018: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29444555/significant-effect-of-anti-tyrosine-kinase-inhibitor-gefitinib-on-overall-survival-of-the-glioblastoma-gbm-patients-in-the-backdrop-of-mutational-status-of-egfr-and-pten-genes
#9
Sajad H Arif, Arshad A Pandith, Rehana Tabasum, Altaf U Ramzan, Sarabjeet Singh, Mushtaq A Siddiqi, Abdul R Bhat
INTRODUCTION: We aimed to assess the effect of antityrosine kinase inhibitors (Geftinib) in overall survival of the GBM patients in the backdrop of mutational status of EGFR and PTEN genes. MATERIALS AND METHODS: All the patients subjected to resection or biopsies were put on Geftinib and radiotherapy was delivered as per the hospital protocol. EGFR and PTEN mutational spectrum was performed by SSCP followed by DNA sequencing. RESULTS: In total, 50% GBM tumors had mutation either in EGFR or PTEN...
February 13, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29443430/small-scale-machines-driven-by-external-power-sources
#10
REVIEW
Xiang-Zhong Chen, Bumjin Jang, Daniel Ahmed, Chengzhi Hu, Carmela De Marco, Marcus Hoop, Fajer Mushtaq, Bradley J Nelson, Salvador Pané
Micro- and nanorobots have shown great potential for applications in various fields, including minimally invasive surgery, targeted therapy, cell manipulation, environmental monitoring, and water remediation. Recent progress in the design, fabrication, and operation of these miniaturized devices has greatly enhanced their versatility. In this report, the most recent progress on the manipulation of small-scale robots based on power sources, such as magnetic fields, light, acoustic waves, electric fields, thermal energy, or combinations of these, is surveyed...
February 14, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29428876/imaging-of-spondylolysis-the-evolving-role-of-magnetic-resonance-imaging
#11
Raza Mushtaq, Jack Porrino, Gloria J Guzmán Pérez-Carrillo
No abstract text is available yet for this article.
February 8, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29421983/emerging-immune-targets-for-the-treatment-of-multiple-myeloma
#12
Atif Sohail, Adeela Mushtaq, Ahmad Iftikhar, Zabih Warraich, Sandra E Kurtin, Pavan Tenneti, Ali McBride, Faiz Anwer
We reviewed emerging immune strategies for multiple myeloma (MM) therapy excluding US FDA approved drugs. In relapsed refractory MM, isatuximab (anti-CD38) monotherapy achieved overall response (OR) of 24%. Other monoclonal antibodies that have shown efficacy in combination therapy include siltuximab (OR: 66%), indatuximab (OR: 78%), isatuximab (OR: 64.5%), pembrolizumab (OR: 60%), bevacizumab (OR: 70%), dacetuzumab (OR: 39%) and lorvotuzumab (OR: 56.4%). No OR was observed with monotherapy using BI-505, siltuximab, bevacizumab, AVE-1642, figitumumab, atacicept, milatuzumab, dacetuzumab, lucatumumab, IPH2101, lorvotuzumab, BT062 and nivolumab...
February 1, 2018: Immunotherapy
https://www.readbyqxmd.com/read/29421716/synthesis-of-benzimidazole-linked-1-3-4-oxadiazole-carboxamides-as-gsk-3%C3%AE-inhibitors-with-in-vivo-antidepressant-activity
#13
Mushtaq A Tantray, Imran Khan, Hinna Hamid, Mohammad Sarwar Alam, Abhijeet Dhulap, Abul Kalam
Recent findings of potential implications of glycogen synthase kinase-3β (GSK-3β) dysfunction in psychiatric disorders like depression, have increased focus for development of GSK-3β inhibitors with possible anti-depressant activity. Keeping this in view, we synthesized a series of benzimidazole-linked-1,3,4-oxadiazole carboxamides and evaluated them for in vitro GSK-3β inhibition. Active compounds were investigated for in vivo antidepressant activity in Wistar rats. Docking studies of active compounds have also been performed...
February 1, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29402191/post-menopausal-bleeding-is-transvaginal-ultrasound-a-useful-first-line-investigation-in-tamoxifen-users
#14
A Abdaal, Y Mushtaq, L Khasati, J Moneim, F Khan, H Ahmed, H Bolton
Objective To evaluate the role of transvaginal ultrasound triage in women with a history of tamoxifen treatment who present with post-menopausal bleeding. Study design A retrospective review was undertaken of patients who presented with symptoms of post-menopausal bleeding and underwent ultrasound triage. Endometrial thickness and ultrasonographic features were then correlated with hysteroscopic and histopathological outcome data. The findings and outcomes for women with a history of tamoxifen use (tamoxifen group) were compared to those who had not taken tamoxifen (non-tamoxifen group)...
January 1, 2018: Post Reproductive Health
https://www.readbyqxmd.com/read/29397887/ten-year-trends-in-traumatic-injury-mechanisms-and-outcomes-a-trauma-registry-analysis
#15
REVIEW
Zhamak Khorgami, William J Fleischer, Yuen-Jing A Chen, Nasir Mushtaq, Michael S Charles, C Anthony Howard
BACKGROUND: The Oklahoma Trauma Registry (OTR) collects data from all state-licensed acute care hospitals. This study investigates trends and outcomes of trauma in Oklahoma using OTR. METHODS: 107,549 patients (2005-2014) with major severity and one of the following criteria were included: length of hospital stay ≥48 h, dead on arrival or death in the hospital, hospital transfer, ICU admission, or surgery on the head, chest, abdomen, or vascular system. Patient characteristics, mechanisms of injury, and outcomes of trauma were analyzed...
January 31, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29396484/the-mrps18-2-protein-levels-correlate-with-prostate-tumor-progression-and-it-induces-cxcr4-dependent-migration-of-cancer-cells
#16
Muhammad Mushtaq, Lasse Jensen, Sabina Davidsson, Oleksandr V Grygoruk, Ove Andrén, Vladimir Kashuba, Elena Kashuba
We have earlier found abnormal expression of the mitochondrial ribosomal protein S18-2 (MRPS18-2, S18-2) in endometrial cancer, compared to the expression in hyperplasia and in normal endometrium. Here we report that expression of S18-2 was increased with disease progression in clinical specimens of prostate cancer (PCa). The level of induction of epithelial to mesenchymal cell transition (EMT) correlated with the expression level of S18-2 in PCa cell lines. Moreover, cells acquired increased ability of migration upon S18-2 overexpression, as was evaluated in zebrafish embryo model and in trans-well assay...
February 2, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29394979/lupus-enteritis-an-atypical-initial-presentation-of-systemic-lupus-erythematosus
#17
Hina Mushtaq, Shahla Razzaque, Kamal Ahmed
Systemic lupus erythematosus may rarely present initially with gastroenteric features labelled as lupus enteritis, that may lead to serious complications, if it remains undiagnosed for a long period of time. It is difficult to diagnose because the clinical picture of lupus enteritis mimics gastroenteritis. The diagnosis is made on radiological findings, rather than histopathology, and supported by autoimmune profile. Here is a case of a 40-year lady who presented with diarrhea and vomiting that was unresponsive to treatment with intravenous antibiotics...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29386663/interpretations-of-autonomous-decision-making-in-antenatal-genetic-screening-among-women-in-china-hong-kong-and-pakistan
#18
Shenaz Ahmed, Huso Yi, Dong Dong, Jianfeng Zhu, Hussain Jafri, Yasmin Rashid, Olivia My Ngan, Mushtaq Ahmed
The concept of informed choice for antenatal screening consists of Western ideologies, encapsulating individualistic approaches, and may be valued differently by people from countries with more collectivist cultures. This study aimed to explore perceptions of informed choice in antenatal screening in women from China, Hong Kong and Pakistan. A Q-methodology study was conducted during June 2016 to February 2017, in China (Shanghai and Duyun), Hong Kong and Pakistan (Lahore). A total of 299 women rank ordered 41 statements...
January 31, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29383781/morpho-palynological-study-of-cyperaceae-from-wetlands-of-azad-jammu-and-kashmir-using-sem-and-lm
#19
Maryam Akram Butt, Muhammad Zafar, Mushtaq Ahmad, Shazia Sultana, Fazal Ullah, Gul Jan, Ali Irfan, Syeda Andleeb Zahra Naqvi
In this study 12 species of Cyperaceae have been studied for quantitative and qualitative observation of pollen grains through Light and scanning electron microscopy. Pollens of 12 species of Cyperaceae from different wetlands of Azad Jammu and Kashmir were collected. Morphological characters of pollen grains were then investigated under the Light and Scanning electron microscope. Two pollen types have been observed apolar and heteropolar. Shape of pollens was prolate (4 spp), sub-spheroidal (7 spp), and oblate (1 spp)...
January 31, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29357795/tolfenamic-acid-a-modifier-of-the-tau-protein-and-its-role-in-cognition-and-tauopathy
#20
J K Chang, A Leso, G M Subaiea, A Lahouel, A Masoud, F Mushtaq, R Deeb, A Eid, M Dash, S W Bihaqi, N H Zawia
OBJECTIVE: Tangles are deposits of hyperphosphorylated tau, which are found in multiple neurodegenerative disorders that are referred to as tauopathies, of which Alzheimer's disease (AD) is the most common. Tauopathies are clinically characterized by dementia and share in common cortical lesions composed of aggregates of the protein tau. METHODS: In this study, we explored the therapeutic potential of tolfenamic acid (TA), in modifying disease processes in a transgenic animal model that carries the human tau gene (hTau)...
January 18, 2018: Current Alzheimer Research
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