keyword
MENU ▼
Read by QxMD icon Read
search

Mushtaq

keyword
https://www.readbyqxmd.com/read/28214708/evaluating-the-role-of-smokeless-tobacco-use-indices-as-brief-measures-of-dependence
#1
Nasir Mushtaq, Laura A Beebe
INTRODUCTION: There is considerable interest in using brief measures of dependence for evaluation and treatment of tobacco dependence. The Heaviness of Smoking Index (HSI) is a validated measure of dependence among cigarette smokers. However, a similar index has not been studied among ST users. The aim of this study is to develop similar ST use indices and evaluate their utility as concise dependence measures. Time to first chew/dip of the day (TTFD), number of cans of ST used per week (CPW), and number of dips/chews per day (DPD) were used to create three ST use indices; heaviness of ST use index (HSTI), ST dependence index (STDI), and ST quantity frequency index (ST-QFI)...
February 10, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28185908/purification-and-biophysical-characterization-of-the-aimp2-dx2-protein
#2
Roshan Jha, Hye Young Cho, Ameeq Ul Mushtaq, Kiho Lee, Dae Gyu Kim, Sunghoon Kim, Young Ho Jeon
Besides their primary role in protein synthesis, aminoacyl-tRNA synthetases (AARSs) are involved in several non-canonical processes such as apoptosis, inflammation and angiogenesis through their interactions with various cellular proteins. Nine of these AARSs interact with three aminoacyl-tRNA synthetase interacting multifunctional proteins (AIMPs), forming a multi-synthetase complex (MSC) in eukaryotes. Among the three AIMPs, AIMP2 is involved in controlling cell proliferation and apoptosis. However, a splicing variant of AIMP2 lacking exon 2, referred to as AIMP2-DX2, is oncogenic and compromises the pro-apoptotic activity of AIMP2 by competing with it for p53 and TRAF2...
February 6, 2017: Protein Expression and Purification
https://www.readbyqxmd.com/read/28179695/a-pcr-method-based-on-18s-rrna-gene-for-detection-of-malaria-parasite-in-balochistan
#3
Zubeda Shahwani, Abdul Aleem, Nazeer Ahmed, Muhammad Mushtaq, Sarwat Afridi
OBJECTIVE: To establish a polymerase chain reaction method based on 18S ribosomal ribonucleic acid gene for the detection of plasmodium deoxyribonucleic acid in patients suffering from malaria symptoms. METHODS: This cross-sectional study was conducted from September 2013 to October 2014 in district Quetta of Pakistan's Balochistan province. Blood samples were collected from patients suffering from general symptoms of malaria. A polymerase chain reaction-based technique was applied for the diagnosis of malaria and detection of responsible species in the patients who were suspected to carry the parasite...
December 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28174326/intravenous-thrombolysis-in-unknown-onset-stroke-results-from-the-safe-implementation-of-treatment-in-stroke-international-stroke-thrombolysis-registry
#4
Laura Dorado, Niaz Ahmed, Götz Thomalla, Manuel Lozano, Branko Malojcic, Mushtaq Wani, Mònica Millán, Ales Tomek, Antoni Dávalos
BACKGROUND AND PURPOSE: Stroke patients with unknown onset (UKO) are excluded from thrombolytic therapy. We aim to study the safety and efficacy of intravenous alteplase in ischemic stroke patients with UKO of symptoms compared with those treated within 4.5 hours in a large cohort. METHODS: Data were analyzed from 47 237 patients with acute ischemic stroke receiving intravenous tissue-type plasminogen activator in hospitals participating in the Safe Implementation of Treatment in Stroke-International Stroke Thrombolysis Registry between 2010 and 2014...
February 7, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28164765/commonalities-in-biological-pathways-genetics-and-cellular-mechanism-between-alzheimer-disease-and-other-neurodegenerative-diseases-an-in-silico-updated-overview
#5
Khurshid Ahmad, Mohammad Hassan Baig, Gohar Mushtaq, Mohammad Amjad Kamal, Nigel H Greig, Inho Choi
Alzheimer's disease (AD) is the most common and well-studied neurodegenerative disease (ND). Biological pathways, pathophysiology and genetics of AD show commonalities with other NDs viz. Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Prion Disease and Dentatorubral-pallidoluysian atrophy (DRPLA). Many of the NDs, sharing the common features and molecular mechanisms suggests that pathology may be directly comparable and be implicated in disease prevention and development of highly effective therapies...
February 3, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28158732/in-vitro-activity-of-cefepime-zidebactam-wck-5222-against-gram-negative-bacteria
#6
David M Livermore, Shazad Mushtaq, Marina Warner, Anna Vickers, Neil Woodford
No abstract text is available yet for this article.
February 3, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28150900/discovery-of-antimicrobial-and-antitubercular-molecules-from-fusarium-solani-an-endophyte-of-glycyrrhiza-glabra
#7
Aiyatullah Shah, Muzafar Ahmad Rather, Parvaiz H Qazi, Mushtaq A Aga, Saleem Mushtaq, Aabid Manzoor Shah, Aehtesham Hussain, Shoib A Baba, Zahoor Ahmad
AIM: Glycyrrhiza glabra is a high value medicinal plant thriving in biodiversity rich Kashmir Himalaya. The present study was designed to explore the fungal endophytes from G glabra as a source of bioactive molecules. METHODS AND RESULTS: The extracts prepared from the isolated endophytes were evaluated for antimicrobial activities using broth micro-dilution assay. The endophytic strain coded as A2 exhibiting promising antibacterial as well as antituberculosis activity was identified as Fusarium solani by ITS-5...
February 2, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28150580/biocompatible-biodegradable-polymeric-antibacterial-nanoparticles-for-enhancing-the-effects-of-the-third-generation-cephalosporin-against-resistant-bacteria
#8
Sana Mushtaq, Jawad Akbar Khan, Faiz Rabbani, Usman Latif, Muhammad Arfan, Muhammad Arfat Yameen
PURPOSE: The present study attempted to enhance the antibacterial activity of ceftriaxone with biodegradable polymer against Gram-positive (MRSA) and -negative (E. coli) bacteria. METHODOLOGY: MRSA and E. coli were collected and identified by biochemical and molecular tests. Blank and ceftriaxone loaded CNPs were prepared by ionic gelation method. The in-vitro antibiotic susceptibility studies were performed by disc diffusion, agar well plate method, E-test and time kill assay...
February 1, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28141802/a-new-variational-approach-for-multiplicative-noise-and-blur-removal
#9
Asmat Ullah, Wen Chen, Mushtaq Ahmad Khan, HongGuang Sun
This paper proposes a new variational model for joint multiplicative denoising and deblurring. It combines a total generalized variation filter (which has been proved to be able to reduce the blocky-effects by being aware of high-order smoothness) and shearlet transform (that effectively preserves anisotropic image features such as sharp edges, curves and so on). The new model takes the advantage of both regularizers since it is able to minimize the staircase effects while preserving sharp edges, textures and other fine image details...
2017: PloS One
https://www.readbyqxmd.com/read/28138939/carboxymethyl-cellulase-production-optimization-from-newly-isolated-thermophilic-bacillus-subtilis-k-18-for-saccharification-using-response-surface-methodology
#10
Muhammad Irfan, Qudsia Mushtaq, Fouzia Tabssum, Hafiz Abdullah Shakir, Javed Iqbal Qazi
In this study, a novel thermophilic strain was isolated from soil and used for cellulase production in submerged fermentation using potato peel as sole carbon source. The bacterium was identified by 16S rRNA gene sequencing technology. Central composite design was applied for enhanced production using substrate concentration, inoculum size, yeast extract and pH as dependent variables. Highest enzyme titer of 3.50 ± 0.11 IU/ml was obtained at 2% substrate concentration, 2% inoculum size, 1% yeast extract, pH 5...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28138187/an-overview-on-phase-variation-mechanisms-and-roles-in-bacterial-adaptation
#11
Sajjad Ahmad, Mushtaq Ahmad, Salman Khan, Faisal Ahmad, Sabir Nawaz, Farman Ullah Khan
In nature, bacteria are exposed to multiple stress conditions posing threat to their life. However, bacteria evolve constantly and employ myriad of genetic and phenotypic strategies for successful survival. One such adaptive process is phase variation - a random, frequent and reversible ON/OFF switching of contingency genes generating phenotypical variations within the bacterial population. Pathogenic and commensal bacteria make use of this heritable process as a tool for adaptation, generating intra-strain diversity and immune evasion...
February 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28134117/updates-in-tuberculosis-diagnosis-in-the-usa
#12
Ammara Mushtaq
No abstract text is available yet for this article.
February 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28126565/impact-of-vitamin-d-supplementation-on-endothelial-and-inflammatory-markers-in-adults-a-systematic-review
#13
Tari Agbalalah, Stephen F Hughes, Ellen J Freeborn, Sohail Mushtaq
This systematic review aims to evaluate randomised controlled trials (RCTs) investigating the effect of vitamin D supplementation on endothelial function and inflammation in adults. An electronic search of published randomised controlled trials, using Cochrane, Pubmed and Medline databases was conducted, with the search terms related to vitamin D and endothelial function. Inclusion criteria were RCTs in adult humans with a measure of vitamin D status using serum/plasma 25(OH)D and studies which administered the intervention through the oral route...
January 23, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28122267/single-nucleotide-polymorphisms-haplotype-association-and-tumour-expression-of-the-vascular-endothelial-growth-factor-vegf-gene-with-lung-carcinoma
#14
Niyaz A Naykoo, Dil-Afroze, Roohi Rasool, Sonaullah Shah, A G Ahangar, Imtiyaz A Bhat, Iqbal Qasim, Mushtaq A Siddiqi, Zafar A Shah
VEGF contains several polymorphic sites known to influence its expression. We examined the possible association between +405(-634) C>G, +936 C>T, -2578 C>A and lung cancer in 199 Kashmiri patients and 401 healthy controls. VEGF +405 CG, +936 CT +TT and -2578 CA genotypes were significantly associated with lung cancer risk compared to VEGF +405 CC, +936 CC and -2578 AA+CC genotypes [OR=0.07 (0.04-0.13), P<0.0001, OR=0.36 (0.25-0.52), P<0.0001 and 0.08 (0.05-0.13), P<0.0001]. Haplotype analysis revealed that CGA and TGA haplotypes of VEGF gene conveys the risk for lung cancer [OR=0...
January 22, 2017: Gene
https://www.readbyqxmd.com/read/28110819/synthesis-of-ofornine-mimics-from-natural-product-l-vasicine-as-anti-hypertensive-agents
#15
Mushtaq A Aga, Sheikh Rayees, Abdul Rouf, Brijesh Kumar, Anjna Sharma, P V V S Nagaraju, Gurdarshan Singh, Subhash C Taneja
We report the chemical synthesis of Ofornine mimics from l-vasicine, structure-activity relationship studies and their in vivo screening for anti-hypertensive action in Wistar rats. It was observed that most of the analogs possessed anti-hypertensive effect; however, the duration of the effect was variable and mostly transient. The results demonstrated that the analogs 12, 13, 14, 15, and 16 showed a sharp and significant decrease in systolic and diastolic blood pressure for 30-60min after intravenous administration...
January 6, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28109006/attitudes-towards-non-invasive-prenatal-diagnosis-among-obstetricians-in-pakistan-a-developing-islamic-country
#16
Shenaz Ahmed, Hussain Jafri, Yasmin Rashid, Gerald Mason, Yasmin Ehsan, Mushtaq Ahmed
OBJECTIVES: Stakeholders' views are essential for informing implementation strategies for non-invasive prenatal testing (NIPT). Little is known about such views in developing countries. We explored attitudes toward NIPT among obstetricians in Pakistan, a developing Islamic country. METHODS: A 35-item questionnaire was distributed and collected at eight events (a national conference and seven workshops in five cities) for obstetric professionals on advances in fetal medicine...
January 20, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28106887/report-of-12-months-efficacy-and-safety-of-intravitreal-fluocinalone-acetonide-implant-for-the-treatment-of-chronic-diabetic-macular-oedema-a-real-world-result-in-the-united-kingdom
#17
F Alfaqawi, P L Lip, S Elsherbiny, R Chavan, A Mitra, B Mushtaq
: PurposeTo report the 12-months visual and anatomical outcomes of chronic diabetic macular oedema (DMO) treated with ILUVIEN in a real-world clinical practice in a single tertiary referral centre.MethodRetrospective data collection and analysis of consecutive 28 eyes of 23 diabetic patients received ILUVIEN implant for refractory DMO. Standard assessment included visual acuity (VA), central retinal thickness (CRT), slit-lamp biomicroscopy, and Goldmann tonometry for intraocular pressure (IOP) at 1, 6, and 12 months...
January 20, 2017: Eye
https://www.readbyqxmd.com/read/28093429/paediatric-ed-bipap-continuous-quality-improvement-programme-with-patient-analysis-2005-2013
#18
Thomas Abramo, Abby Williams, Samaiya Mushtaq, Mark Meredith, Rawle Sepaule, Kristen Crossman, Cheryl Burney Jones, Suzanne Godbold, Zhuopei Hu, Todd Nick
OBJECTIVE: In paediatric moderate-to-severe asthmatics, there is significant bronchospasm, airway obstruction, air trapping causing severe hyperinflation with more positive intraplural pressure preventing passive air movement. These effects cause an increased respiratory rate (RR), less airflow and shortened inspiratory breath time. In certain asthmatics, aerosols are ineffective due to their inadequate ventilation. Bilevel positive airway pressure (BiPAP) in acute paediatric asthmatics can be an effective treatment...
January 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28065978/spontaneous-bilateral-quadriceps-rupture-in-a-patient-with-ankylosing-spondylitis-a-case-report
#19
Azib Shahid, Hafiz Shahid Mushtaq, Syed Muhammad Azfar
Ankylosing spondylitis is a prototype rheumatoid factor-negative spondyloarthropathy that causes the vertebrae to fuse making the spine less flexible, resulting in a hunched-forward posture. A 47-year-old male who was a known case of ankylosing spondylitis presented with left quadriceps rupture after raising his right foot to lightly hit a football. He was fitted with a knee immobilizer as an emergency measure. The extent of the rupture was not yet established when patient requested leave to go home. The right quadriceps was ruptured as well when he took his immobilizer off to go the bathroom...
January 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28062106/medical-geology-in-the-framework-of-the-sustainable-development-goals
#20
REVIEW
Jochen Bundschuh, Jyoti Prakash Maity, Shahbaz Mushtaq, Meththika Vithanage, Saman Seneweera, Jerusa Schneider, Prosun Bhattacharya, Nasreen Islam Khan, Ihsan Hamawand, Luiz R G Guilherme, Kathryn Reardon-Smith, Faruque Parvez, Nury Morales-Simfors, Sara Ghaze, Christa Pudmenzky, Louis Kouadio, Chien-Yen Chen
Exposure to geogenic contaminants (GCs) such as metal(loid)s, radioactive metals and isotopes as well as transuraniums occurring naturally in geogenic sources (rocks, minerals) can negatively impact on environmental and human health. The GCs are released into the environment by natural biogeochemical processes within the near-surface environments and/or by anthropogenic activities such as mining and hydrocarbon exploitation as well as exploitation of geothermal resources. They can contaminate soil, water, air and biota and subsequently enter the food chain with often serious health impacts which are mostly underestimated and poorly recognized...
January 3, 2017: Science of the Total Environment
keyword
keyword
108993
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"