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Muhammad Imtiaz, Muhammad Adnan Mushtaq, Muhammad Amjad Nawaz, Muhammad Ashraf, Muhammad Shahid Rizwan, Sajid Mehmood, Omar Aziz, Muhammad Rizwan, Muhammad Safiullah Virk, Qaiser Shakeel, Raina Ijaz, Vasilis P Androutsopoulos, Aristides M Tsatsakis, Michael D Coleman
The present study aimed to elucidate the photosynthetic performance, antioxidant enzyme activities, anthocyanin contents, anthocyanin biosynthetic gene expression, and vanadium uptake in mustard genotypes (purple and green) that differ in photosynthetic capacity under vanadium stress. The results indicated that vanadium significantly reduced photosynthetic activity in both genotypes. The activities of the antioxidant enzymes were increased significantly in response to vanadium in both genotypes, although the purple exhibited higher...
June 13, 2018: Environmental Toxicology and Pharmacology
Daniele Andreini, Saima Mushtaq, Gianluca Pontone, Edoardo Conte, Jeroen Sonck, Carlos Collet, Marco Guglielmo, Andrea Baggiano, Daniela Trabattoni, Stefano Galli, Piero Montorsi, Cristina Ferrari, Franco Fabbiocchi, Stefano De Martini, Andrea Annoni, Maria Elisabetta Mancini, Alberto Formenti, Marco Magatelli, Marta Resta, Elisa Consiglio, Giuseppe Muscogiuri, Cesare Fiorentini, Antonio L Bartorelli, Mauro Pepi
BACKGROUND: Recent studies demonstrated a significant improvement in the diagnostic performance of coronary CT angiography (CCTA) for the evaluation of in-stent restenosis (ISR). However, coronary stent assessment is still challenging, especially because of beam-hardening artifacts due to metallic stent struts and high atherosclerotic burden of non-stented segments. Adenosine-stress myocardial perfusion assessed by CT (CTP) recently demonstrated to be a feasible and accurate tool for evaluating the functional significance of coronary stenoses in patients with suspected coronary artery disease (CAD)...
June 18, 2018: Journal of Cardiovascular Computed Tomography
Adnan I Qureshi, Danish Kherani, Muhammad A Waqas, Mushtaq H Qureshi, Faisal M Raja, Shawn S Wallery
BACKGROUND: We performed a prospective study to quantify changes in various aspects of upright posture intolerance in patients with intracranial hypotension. METHODS: Six patients were provided a standard questionnaire before, immediately after epidural blood patch injection and at follow-up visit within 1 month after epidural blood injection inquiring: (a) How long can they stand straight without any support? (b) Do they feel any sense of sickness when they sit or lie down after standing? (c) How long do they have to wait before they are comfortable standing again after they have stood straight? (d) How effectively and fast can they get up from sitting or lying position to stand straight? and (e) Rate their activities in upright posture without support on a standard vertical visual analogue scale between 100 (can do everything) and 0 (cannot do anything)...
June 19, 2018: Brain and Behavior
Anna Vickers, Shazad Mushtaq, Neil Woodford, Michel Doumith, David M Livermore
Pyrrolocytosines RX-04A-D are designed to bind to the bacterial 50S ribosomal subunit differently from currently-used antibiotics. The four analogs had broad anti-Gram-negative activity: RX-04A inhibited 94.7% of clinical Enterobacteriaceae , Acinetobacter baumannii and Pseudomonas aeruginosa at 0.5-4 μg/ml, with no MICs >8 μg/ml. MICs for multi-resistant carbapenemase producers were up to two-fold higher than for control strains, with values ≥8 μg/ml for one Serratia isolate with porin and efflux lesions...
June 18, 2018: Antimicrobial Agents and Chemotherapy
Mushtaq Ahmad, Khalid P Akhtar
The cotton whitefly Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) is a serious pest of several summer crops in hot and dry climates. Its field populations (Asia II-1 biotype) were assessed for their susceptibility to diverse pesticides by using leaf-dip bioassay. There was no or a very low resistance to amitraz, hexythiazox, and pyridaben during 1992-2015. B. tabaci also exhibited no resistance to endosulfan during 1992-1997 and a very low resistance during 1998-2010, which then rose to a low level during 2011-2015...
April 18, 2018: Journal of Economic Entomology
Muhammad Umer Farooq, Fahad Mushtaq, Zoha Naeem, Safa Iqbal, Sajida Naseem, Osama Ishtiaq
OBJECTIVE: To determine the relation between food intake and diabetes control. METHODS: This cross-sectional study was carried out at Department of Medicine and Endocrinology, Shifa International Hospital, Islamabad, Pakistan, from July 2016 to February 2017, during which type-2 diabetes patients were interviewed using a structured questionnaire. Demographics, intake of high glycaemic index foods consumed in each food group, and general dietary practices were assessed by means of number of meals per day and adherence to the dietary plan...
May 2018: JPMA. the Journal of the Pakistan Medical Association
Mashooq Ahmad Bhat, Mohamed A Al-Omar, Mohammad Raish, Mushtaq Ahmad Ansari, Hatem A Abuelizz, Ahmed H Bakheit, Ahmed M Naglah
A new series of 2-(5-methoxy-2-methyl-1 H -indol-3-yl)- N ′-[( E )-(substituted phenyl) methylidene] acetohydrazide derivatives ( S1 ⁻ S18 ) were synthesized and evaluated for their anti-inflammatory activity, analgesic activity, ulcerogenic activity, lipid peroxidation, ulcer index and cyclooxygenase expression activities. All the synthesized compounds were in good agreement with spectral and elemental analysis. Three synthesized compounds ( S3 , S7 and S14 ) have shown significant anti-inflammatory activity as compared to the reference drug indomethacin...
May 24, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Roqia Ashraf, Hasham S Sofi, Aijaz Malik, Mushtaq A Beigh, Rabia Hamid, Faheem A Sheikh
Electrospinning a versatile and the most preferred technique for the fabrication of nanofibers has revolutionized by opening unlimited avenues in biomedical fields. Presently, the simultaneous functionalization and/or post-modification of as-spun nanofibers with biomolecules has been explored, to serve the distinct goals in the aforementioned field. Starch is one of the most abundant biopolymers on the earth. Besides, being biocompatible and biodegradable in nature, it has unprecedented properties of gelatinization and retrogradation...
June 8, 2018: Applied Biochemistry and Biotechnology
Abdul Rehman, Muhammad Ghazanfar Husnain, Kamran Mushtaq, Mohsen Saleh Eledrisi
Cerebral venous sinus thrombosis usually occurs in patients with a precipitating condition such as thrombophilic disorders, pregnancy or due to medications, such as oestrogens. Some case reports have reported the co-occurrence of cerebral venous sinus thrombosis in patients with hyperthyroidism. However, the association of cerebral venous sinus thrombosis with hyperthyroidism remains contentious. We present the case of a patient who presented with a clinical picture of cerebral venous sinus thrombosis with no obvious precipitating factor...
June 4, 2018: BMJ Case Reports
Saima Mushtaq, Inamullah Shah, Eitezaz Ahmed Bashir
Axillary artery aneurysm is a rare condition. Though mostly asymptomatic, it should be treated early as it can develop thrombosis, distal embolisation, pressure symptoms or rupture. We report here a case of a 24-year woman who presented with neurological deficit in her arm because of pressure by axillary artery aneurysm. Standard treatment of these aneurysms is excision and replacement with an interposition graft. We used reversed saphenous vein as interposition graft between axillary and brachial artery.
June 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Ha Eun Shim, Jae Young Lee, Chang Heon Lee, Sajid Mushtaq, Ha Yeon Song, Lee Song, Seong-Jin Choi, Kyuhong Lee, Jongho Jeon
To assess the risk posed by a toxic chemical to human health, it is essential to quantify its uptake in a living subject. This study aims to investigate the biological distribution of inhaled polyhexamethylene guanidine (PHMG) aerosol particle, which is known to cause severe pulmonary damage. By labeling with indium-111 (111 In), we quantified the uptake of PHMG for up to 7 days after inhalation exposure in rats. The data demonstrate that PHMG is only slowly cleared, with approximately 74% of inhaled particles persisting in the lungs after 168 h...
May 25, 2018: Chemosphere
Saurabh Bansal, Kunal Das, Navneet Jain, Vipul Nautiyal, Meenu Gupta, Nadia Shirazi, Sanjiv Verma, Mushtaq Ahmad, Sunil Saini
Introduction: The most common site for soft tissue sarcoma is extremity. As complete surgical resection is possible in majority, outcome of this subset is relatively better. There is paucity of data regarding extremity soft tissue sarcoma (STS) from sub-Himalayan and hilly geographical regions. Materials and Methods: Retrospective analysis was done for extremity STS visiting the study center over a period of 5 years. Data were collected and analyzed for demography, disease characteristics, treatment modalities, and outcome...
2018: Sarcoma
Shahid Bashir, Yin Yin Teo, S Ramesh, K Ramesh, Muhammad Waheed Mushtaq
Novel pH sensitive N-succinyl chitosan-g-poly (acrylic acid) hydrogels were synthesized through free radical mechanism. Rheometer was used to observe the mechanical strength of the hydrogels. In vitro degradation was conducted in SIF (pH 7.4). The effect of concentration of monomers, initiator, and crosslinking agent and pH and ionic strength of NaCl, CaCl2 , and AlCl3 on swelling of the hydrogels was observed. The results showed that equilibrium swelling ratio was highly influenced by concentration of monomers, initiator, and crosslinking agent concentration, and pH and salt solutions of NaCl, CaCl2 , and AlCl3 ...
May 25, 2018: International Journal of Biological Macromolecules
Sadaf Mushtaq, Bilal Haider Abbasi, Bushra Uzair, Rashda Abbasi
Since ancient times, natural products from plants, animals, microbial and marine sources have been exploited for treatment of several diseases. The knowledge of our ancestors is the base of modern drug discovery process. However, due to the presence of extensive biodiversity in natural sources, the percentage of secondary metabolites screened for bioactivity is low. This review aims to provide a brief overview of historically significant natural therapeutic agents along with some current potential drug candidates...
2018: EXCLI Journal
Adnan I Qureshi, Yuko Y Palesch, Lydia D Foster, William G Barsan, Joshua N Goldstein, Daniel F Hanley, Chung Y Hsu, Claudia S Moy, Mushtaq H Qureshi, Robert Silbergleit, Jose I Suarez, Kazunori Toyoda, Haruko Yamamoto
BACKGROUND AND PURPOSE: We compared the rates of death or disability, defined by modified Rankin Scale score of 4 to 6, at 3 months in patients with intracerebral hemorrhage according to post-treatment systolic blood pressure (SBP)-attained status. METHODS: We divided 1000 subjects with SBP ≥180 mm Hg who were randomized within 4.5 hours of symptom onset as follows: SBP <140 mm Hg achieved or not achieved within 2 hours; subjects in whom SBP <140 mm Hg was achieved within 2 hours were further divided: SBP <140 mm Hg for 21 to 22 hours (reduced and maintained) or SBP was ≥140 mm Hg for at least 2 hours during the period between 2 and 24 hours (reduced but not maintained)...
June 2018: Stroke; a Journal of Cerebral Circulation
J S Thomas, N Smeulders, F Yankovic, S Undre, I Mushtaq, P-J López, P Cuckow
INTRODUCTION: Bladder calculi are a known complication of bladder augmentation. Open cystolithotomy remains the preferred option for treating large or multiple stones. Increasingly, however, minimal access techniques have been used. Reports of Mitrofanoff cystolitholapaxy are rare and have been limited to adults. This study presented a two centre series of children treated by cystolitholapaxy via the Mitrofanoff/Monti channel. MATERIALS AND METHODS: With institutional approval the current study retrospectively reviewed and identified 14 patients, on a prospective database, who underwent Mitrofanoff cystolitholapaxy to treat bladder calculi at two independent institutions in the UK and Chile between 2004 and 2016...
April 4, 2018: Journal of Pediatric Urology
Suzannah M Schmidt-Malan, Avisya J Mishra, Ammara Mushtaq, Cassandra L Brinkman, Robin Patel
Understanding which antimicrobial agents are likely to be active against Gram-negative bacilli can guide selection of antimicrobials for empiric therapy as mechanistic-based (i.e., molecular) rapid diagnostics are adopted. Here, we determined the MICs of the novel β-lactam/β-lactamase inhibitor combination, imipenem-relebactam, along with ceftolozane-tazobactam, imipenem, ertapenem, meropenem, ceftriaxone, and cefepime, against 283 multidrug resistant isolates of Gram-negative bacilli. For isolates harboring bla KPC (n=111), the addition of relebactam to imipenem lowered the MIC50 /MIC90 from 16/>128 μg/ml for imipenem alone to 0...
May 14, 2018: Antimicrobial Agents and Chemotherapy
Ammar Mushtaq, Meraj Mustafa, Tasawer Hayat, Ahmed Alsaedi
Here we utilize a non-Fourier approach to model buoyancy aiding or opposing flow of Maxwell fluid in the region of stagnation-point towards a vertical stretchable surface. Flow field is permeated by uniform transverse magnetic field. Two different heating processes namely (i) prescribed surface temperature (PST) and (ii) constant wall temperature (CWT) are analyzed. Through suitable transformations, the similarity equations are formed which are treated numerically for a broad range of magnetic interaction parameter...
2018: PloS One
Kiarash Taghavi, Jan Trachta, Imran Mushtaq
No abstract text is available yet for this article.
May 4, 2018: Archives of Disease in Childhood
Zainab Kaleem, Junaid Ali Khan, Zahid Mushtaq, Sidra Altaf, Ijaz Javed
Cardiac patients with weak immune system are susceptible to bacterial infections. Their prescriptions frequently contain simvastatin and clarithromycin together. The objective of present project was to assess the potential interaction between simvastatin and clarithromycin by evaluating the clarithromycin effects on the pharmacokinetics of simvastatin in healthy adult male subjects. The study design comprised of two phases, used at interval of one week. In first phase simvastatin 20 mg alone was administered to each volunteer...
May 2018: Pakistan Journal of Pharmaceutical Sciences
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