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https://www.readbyqxmd.com/read/28345174/overall-evaluability-of-low-dose-protocol-for-computed-tomography-angiography-of-thoracic-aorta-using-80%C3%A2-kv-and-iterative-reconstruction-algorithm-using-different-concentration-contrast-media
#1
Andrea Daniele Annoni, Maria E Mancini, Daniele Andreini, Alberto Formenti, Saima Mushtaq, Enrica Nobili, Marco Guglielmo, Andrea Baggiano, Edoardo Conte, Mauro Pepi
INTRODUCTION: Multidetector Computed Tomography Angiography (MDCTA) is presently the imaging modality of choice for aortic disease. However, the effective radiation dose and the risk related to the use of contrast agents associated with MDCTA is an issue of concern. Aim of this study was to assess image quality of a low dose ECG-gated MDCTA of thoracic aorta using different concentration contrast media without tailored injection protocol. METHODS: Two-hundred patients were randomised into four different scan protocols: Group A (Iodixanol 320 and 80 Kvp tube voltage), Group B (Iodixanol 320 and 100 Kvp tube voltage), Group C (Iomeprol 400 and 80 Kvp tube voltage) and Group D (Iomeprol 400 and 100 Kvp tube voltage)...
March 27, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28334290/field-evolved-resistance-of-bemisia-tabaci-hemiptera-aleyrodidae-to-carbodiimide-and-neonicotinoids-in-pakistan
#2
Mushtaq Ahmad, Rashid A Khan
The evolution of resistance to carbodiimide (a toxic metabolite of diafenthiuron) and four neonicotinoids imidacloprid, acetamiprid, thiamethoxam, and thiacloprid in the Pakistani populations of sweetpotato whitefly (Bemisia tabaci Gennadius) was monitored from 1996 to 2015 using a leaf-dip bioassay. Diafenthiuron, imidacloprid, and acetamiprid were introduced into Pakistani agriculture in mid-1990s and heavily used since then, because B. tabaci resistance and consequently control failures to conventional insecticides such as organophosphates, carbamates, and pyrethroids were widespread during the 1990s...
March 3, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28333319/wck-4234-a-novel-diazabicyclooctane-potentiating-carbapenems-against-enterobacteriaceae-pseudomonas-and-acinetobacter-with-class-a-c-and-d-%C3%AE-lactamases
#3
Shazad Mushtaq, Anna Vickers, Neil Woodford, David M Livermore
Background: Several diazabicyclooctanes (DBOs) are under development as inhibitors of class A and C β-lactamases. Inhibition of OXA (class D) carbapenemases is variable, with those of Acinetobacter spp. remaining notably resistant. We describe a novel DBO, WCK 4234 (Wockhardt), with distinctive activity against OXA carbapenemases. Methods: MICs of imipenem and meropenem were determined by CLSI agar dilution with WCK 4234 added at 4 or 8 mg/L. Test organisms were clinical Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa with carbapenemases or carbapenem resistance via porin loss plus AmpC or ESBL activity...
February 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28332491/corrigendum-endocytic-recycling-protein-ehd1-regulates-primary-cilia-morphogenesis-and-shh-signaling-during-neural-tube-development
#4
Sohinee Bhattacharyya, Mark A Rainey, Priyanka Arya, Bhopal C Mohapatra, Insha Mushtaq, Samikshan Dutta, Manju George, Matthew D Storck, Rodney D McComb, David Muirhead, Gordon L Todd, Karen Gould, Kaustubh Datta, Janee Gelineau-van Waes, Vimla Band, Hamid Band
No abstract text is available yet for this article.
March 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331956/enzyme-assisted-supercritical-fluid-extraction-an-alternative-and-green-technology-for-non-extractable-polyphenols
#5
Muhammad Mushtaq, Bushra Sultana, Sumia Akram, Farooq Anwar, Ahmad Adnan, Syed S H Rizvi
This contribution proposes an enzyme-assisted eco-friendly process for the extraction of non-extractable polyphenols (NEPPs) from black tea leftover (BTLO), an underutilized tea waste. BTLO hydrolyzed with various enzyme formulations was extracted using supercritical carbon dioxide and ethanol as co-solvent (SC-CO2 + EtOH). A conventional solvent extraction (CSE) was performed using EtOH + H2O (80:20, v/v) for comparison purposes. The results revealed that hydrolysis of BTLO with 2.9% (w/w) kemzyme at 45 °C and pH 5...
March 22, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28319023/isolated-bilateral-simplex-ureteric-ectopia-bladder-capacity-as-an-indicator-of-continence-outcome
#6
Vasilis Stavrinides, Paul Charlesworth, Dan Wood, Divyesh Desai, Abraham Cherian, Imran Mushtaq, Peter Cuckow, Naima Smeulders
INTRODUCTION: Isolated bilateral simplex ectopic ureters (BSEUs) are rare but pose a therapeutic challenge: ureteric reimplantation alone does not accomplish continence in all. Identifying the patients needing additional procedures for continence early could prevent multiple operations. OBJECTIVE: Potential preoperative indicators for postoperative continence are explored in eight BSEU girls without cloacal, anorectal, or spinal anomalies. STUDY DESIGN: With institutional approval, all patients with BSEU between 1985 and 2012 were retrospectively reviewed...
March 6, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28317956/efficient-bioremediation-of-radioactive-iodine-using-biogenic-gold-nanomaterial-containing-radiation-resistant-bacterium-deinococcus-radiodurans-r1
#7
Mi Hee Choi, Sun-Wook Jeong, Ha Eun Shim, Seong-Jae Yun, Sajid Mushtaq, Dae Seong Choi, Beom-Su Jang, Jung Eun Yang, Yong Jun Choi, Jongho Jeon
We herein report a new bioremediation method using a radiation-resistant bacterium. Biogenic gold nanomaterial-containing Deinococcus radiodurans R1 showed excellent capability for the removal of radioactive iodine (>99%) in several aqueous solutions. These observations demonstrated that our remediation system would be efficiently applied to the treatment of radioactive wastes.
March 20, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28303480/erratum-to-use-of-fentanyl-in-adolescents-with-clinically-severe-obesity-undergoing-bariatric-surgery-a-pilot-study
#8
Janelle D Vaughns, Victoria C Ziesenitz, Elaine F Williams, Alvina Mushtaq, Ricarda Bachmann, Gisela Skopp, Johanna Weiss, Gerd Mikus, Johannes N van den Anker
No abstract text is available yet for this article.
March 16, 2017: Paediatric Drugs
https://www.readbyqxmd.com/read/28302422/paramedic-assessment-of-older-adults-after-falls-including-community-care-referral-pathway-cluster-randomized-trial
#9
Helen A Snooks, Rebecca Anthony, Robin Chatters, Jeremy Dale, Rachael T Fothergill, Sarah Gaze, Mary Halter, Ioan Humphreys, Marina Koniotou, Phillipa Logan, Ronan A Lyons, Suzanne Mason, Jon Nicholl, Julie Peconi, Ceri Phillips, Alison Porter, Aloysius Niroshan Siriwardena, Mushtaq Wani, Alan Watkins, Lynsey Wilson, Ian T Russell
STUDY OBJECTIVE: We aim to determine clinical and cost-effectiveness of a paramedic protocol for the care of older people who fall. METHODS: We undertook a cluster randomized trial in 3 UK ambulance services between March 2011 and June 2012. We included patients aged 65 years or older after an emergency call for a fall, attended by paramedics based at trial stations. Intervention paramedics could refer the patient to a community-based falls service instead of transporting the patient to the emergency department...
March 13, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28294049/in-silico-analysis-of-amp-activated-protein-kinase-and-ligand-based-virtual-screening-for-identification-of-novel-ampk-activators
#10
Ammarah Ghaffar, Sidra Batool, Gohar Mushtaq, Muhammad Amjad Kamal
BACKGROUND: Adenosine-Monophosphate-Activated protein kinase (AMPK) is a conserved kinase that plays an important role in maintaining the homeostasis of cells. AMPK activation has a positive impact on treatment of diseases such as diabetes, obesity and cancer as well. This observation led to the development of AMPK activators. Certain naturally occurring compounds have also been known to activate AMPK. METHOD: In this study, we retrieved the AMPK activators that includes chemical drugs, xenobiotics and natural compounds and analyzed their interactions with AMPK via docking studies...
March 9, 2017: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/28286150/antimicrobial-activity-of-crude-fractions-and-morel-compounds-from-wild-edible-mushrooms-of-north-western-himalaya
#11
Nowsheen Shameem, Azra N Kamili, Mushtaq Ahmad, F A Masoodi, Javid A Parray
The antimicrobial properties of morel compounds from wild edible mushrooms (Morchella esculenta and Verpa bohemica) from Kashmir valley was investigated against different clinical pathogens. The butanol crude fraction of most popular or true morel M. esculenta showed highest 19 mm IZD against E.coli while as same fraction of Verpa bohemica exhibited 15 mm IZD against same strain. The ethyl acetate and butanol crude fractions of both morels also exhibited good antifungal activity with highest IZD shown against A...
March 7, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28283764/mental-practice-with-interactive-3d-visual-aids-enhances-surgical-performance
#12
Marina Yiasemidou, Daniel Glassman, Faisal Mushtaq, Christos Athanasiou, Mark-Mon Williams, David Jayne, Danilo Miskovic
BACKGROUND: Evidence suggests that Mental Practice (MP) could be used to finesse surgical skills. However, MP is cognitively demanding and may be dependent on the ability of individuals to produce mental images. In this study, we hypothesised that the provision of interactive 3D visual aids during MP could facilitate surgical skill performance. METHODS: 20 surgical trainees were case-matched to one of three different preparation methods prior to performing a simulated Laparoscopic Cholecystectomy (LC)...
March 10, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28271015/lactate-based-optical-screening-of-dengue-virus-infection-in-human-sera-using-raman-spectroscopy
#13
Muhammad Bilal, Rahat Ullah, Saranjam Khan, Hina Ali, Muhammad Saleem, Mushtaq Ahmed
This study presents the screening of dengue virus (DENV) infection in human blood sera based on lactate concentration using Raman spectroscopy. A total of 70 samples, 50 from confirmed DENV infected patients and 20 from healthy volunteers have been used in this study. Raman spectra of all these samples have been acquired in the spectral range from 600 cm(-1) to 1800 cm(-1) using a 532 nm laser as an excitation source. Spectra of all these samples have been analyzed for assessing the biochemical changes resulting from infection...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28261422/a-comprehensive-analysis-of-the-causes-and-predictors-of-30-day-mortality-following-hip-fracture-surgery
#14
Hassaan Qaiser Sheikh, Fahad Siddique Hossain, Adeel Aqil, Babawande Akinbamijo, Vhaid Mushtaq, Harish Kapoor
BACKGROUND: A fracture neck of femur is the leading cause of injury-related mortality in the elderly population. The 30-day mortality figure is a well utilised marker of clinical outcome following a fracture neck of femur. Current studies fail to analyse all patient demographic, biochemical and comorbid parameters associated with increased 30-day mortality. We aimed to assess medical risk factors for mortality, which are easily identifiable on admission for patients presenting with a fractured neck of femur...
March 2017: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/28258153/rationalized-design-of-a-mucosal-vaccine-protects-against-mycobacterium-tuberculosis-challenge-in-mice
#15
Mushtaq Ahmed, Hongmei Jiao, Racquel Domingo-Gonzalez, Shibali Das, Kristin L Griffiths, Javier Rangel-Moreno, Uma M Nagarajan, Shabaana A Khader
Pulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is a leading cause of global morbidity and mortality. The only licensed TB vaccine, Mycobacterium bovis bacillus Calmette-Guerin (BCG), has variable efficacy in protecting against pulmonary TB. Thus, the development of more effective TB vaccines is critical to control the TB epidemic. Specifically, vaccines delivered through the mucosal route are known to induce Th17 responses and provide superior protection against Mtb infection. However, already tested Th17-inducing mucosal adjuvants, such as heat-labile enterotoxins and cholera toxins, are not considered safe for use in humans...
March 3, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28249219/psoriasis-like-inflammation-leads-to-renal-dysfunction-via-upregulation-of-nadph-oxidases-and-inducible-nitric-oxide-synthase
#16
Naif O Al-Harbi, Ahmed Nadeem, Mushtaq A Ansari, Mohammed M Al-Harbi, Moureq R Alotaibi, Abdulaziz M S AlSaad, Sheikh F Ahmad
Psoriatic patients have systemic inflammation as well as oxidative stress, which are associated with cardiovascular disorders such as atherosclerosis, hypertension myocardial infarction, and stroke. Psoriasis has also been shown to be associated with kidney disease in several studies. Both disorders also have strong component of oxidative stress which usually emanates from NADPH oxidases (NOXs) and inducible nitric oxide synthase (iNOS). However, whether psoriatic inflammation leads to renal oxidative stress and dysfunction remains unexplored...
February 26, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28247854/semiconductor-to-metal-transition-in-the-bulk-of-wse2-upon-potassium-intercalation
#17
Mushtaq Ahmad, Eric Müller, Carsten Habenicht, Roman Schuster, Martin Knupfer, Bernd Büchner
We present electron energy-loss spectroscopic measurements of potassium (K) intercalated tungsten diselenide (WSe2). After exposure of pristine WSe2 films to potassium, we observe a charge carrier plasmon excitation at about 0.97 eV, which indicates a semiconductor-to-metal transition. Our data reveal the formation of one particular doped K-WSe2 phase. A Kramers-Kronig analysis allows the determination of the dielectric function and the estimation of the composition of K0.6WSe2. Momentum dependent measurements reveal a substantial plasmon dispersion to higher energies...
April 26, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28245518/altered-translational-repression-of-an-rna-binding-protein-elav-by-aoa2-causative-senataxin-mutation
#18
Saumitra Dey Choudhury, Ancy Vs, Zeeshan Mushtaq, Vimlesh Kumar
Mutations in Senataxin (SETX) gene causes two types of neurological disorders, Amyotrophic Lateral Sclerosis (ALS4) and Ataxia with Oculomotor Apraxia type 2 (AOA2). Recent studies in cultured cells suggest that SETX plays a crucial role at the interface of transcription and the DNA damage response. Whether SETX can alter translational of specific RNA is not known. In this study, we report that expressing AOA2-causative truncated form of human SETX in Drosophila neurons alters the development of neuromuscular junction (NMJ) synapses...
February 28, 2017: Synapse
https://www.readbyqxmd.com/read/28238214/self-reported-substance-use-in-iraq-findings-from-the-iraqi-national-household-survey-of-alcohol-and-drug-use-2014
#19
Nesif Al-Hemiery, Rufaidah Dabbagh, Mushtaq T Hashim, Salih Al-Hasnawi, Ali Abutiheen, Emad A Abdulghani, Jawad K Al-Diwan, Neeraj Kak, Hala AlMossawi, Jane Carlisle Maxwell, Mary-Lynn Brecht, Valerie Antonini, Albert Hasson, Richard A Rawson
AIMS: To estimate the prevalence of tobacco, alcohol, and drug use in Iraq using data from the Iraqi National Household Survey of Alcohol and Drug Use (INHSAD). DESIGN: A cross-sectional survey was conducted using a multi-stage cluster sampling method. Trained surveyors conducted face-to-face household interviews. SETTING: Iraq, from April 2014 to December 2014. PARTICIPANTS: 3,200 adult, non-institutionalized Iraqi citizens residing across all 18 governorates of Iraq...
February 26, 2017: Addiction
https://www.readbyqxmd.com/read/28238111/use-of-fentanyl-in-adolescents-with-clinically-severe-obesity-undergoing-bariatric-surgery-a-pilot-study
#20
Janelle D Vaughns, Victoria C Ziesenitz, Elaine F Williams, Alvina Mushtaq, Ricarda Bachmann, Gisela Skopp, Johanna Weiss, Gerd Mikus, Johannes N van den Anker
BACKGROUND: The number of obese pediatric patients requiring anesthesia is rapidly increasing. Although fentanyl is a commonly used narcotic during surgery, there are no pharmacokinetic (PK) data available for optimal dosing of fentanyl in adolescents with clinically severe obesity. MATERIALS AND METHODS: An institutional review board-approved exploratory pilot study was conducted in six adolescents aged 14-19 years undergoing bariatric surgery. Mean total body weight (TBW) and mean BMI were 137...
February 25, 2017: Paediatric Drugs
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