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https://www.readbyqxmd.com/read/29025597/upregulation-of-vascular-endothelial-growth-factor-vegf-its-role-in-progression-and-prognosis-of-non-small-cell-lung-carcinoma
#1
Niyaz A Naikoo, Roohi Rasool, Sonaullah Shah, A G Ahangar, Mushtaq A Siddiqi, Zafar A Shah
Elevated VEGF mRNA (-ΔCT) was significantly associated with adenocarcinoma histology (vs squamous) and advanced NSCLC clinical stages in a univariable analysis; however, this association did not remain significant in the multivariable analysis. Of interest, a Kaplan-Meier analysis showed that NSCLC patients with higher VEGF mRNA (-ΔCT ≥10) had a significantly poorer overall survival and shorter postoperative relapse time in adenocarcinoma and in stage III/IV than those with VEGF mRNA of -ΔCT <10 (P < 0...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29018974/catalytic-diversity-and-homotropic-allostery-of-two-cytochrome-p450-monooxygenase-like-proteins-from-trichoderma-brevicompactum
#2
Razak Hussain, Indu Kumari, Shikha Sharma, Mushtaq Ahmed, Tabreiz Ahmad Khan, Yusuf Akhter
Trichothecenes are the secondary metabolites produced by Trichoderma spp. Some of these molecules have been reported for their ability to stimulate plant growth by suppressing plant diseases and hence enabling Trichoderma spp. to be efficiently used as biocontrol agents in modern agriculture. Many of the proteins involved in the trichothecenes biosynthetic pathway in Trichoderma spp. are encoded by the genes present in the tri cluster. Tri4 protein catalyzes three consecutive oxygenation reaction steps during biosynthesis of isotrichodiol in the trichothecenes biosynthetic pathway, while tri11 protein catalyzes the C4 hydroxylation of 12, 13-epoxytrichothec-9-ene to produce trichodermol...
October 10, 2017: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29017925/evolution-of-catalytic-microenvironment-governs-substrate-and-product-diversity-in-trichodiene-synthase-and-other-terpene-fold-enzymes
#3
Indu Kumari, Mushtaq Ahmed, Yusuf Akhter
Trichodiene synthase, a terpene fold enzyme catalyzes the first reaction of trichodermin biosynthesis that is an economically important secondary metabolite. Sequence search analysis revealed that the proteins containing terpene fold are present in bacteria, fungi and plants. Terpene fold protein from Selaginella moellendorffii, a lycophyte, appeared at the interface of the microbes and plants in the evolutionary scale. Amino acid residues present around the catalytic pocket determines the size of the substrate as well as product molecules...
October 7, 2017: Biochimie
https://www.readbyqxmd.com/read/28989500/prospective-multicentre-study-in-intensive-care-units-in-five-cities-from-the-kingdom-of-saudi-arabia-impact-of-the-international-nosocomial-infection-control-consortium-inicc-multidimensional-approach-on-rates-of-central-line-associated-bloodstream-infection
#4
Hail M Al-Abdely, Areej Dhafer Alshehri, Victor Daniel Rosenthal, Yassir Khidir Mohammed, Weam Banjar, Pablo Wenceslao Orellano, Abdullah Mufareh Assiri, Nahla Moustafa Abedel Kader, Hessa Abdullah Al Enizy, Diaa Abdullah Mohammed, Duaa Khalil Al-Awadi, Analen Fabros Cabato, Maria Wasbourne, Randa Saliya, Rosita Gasmin Aromin, Evangelina Balon Ubalde, Hanan Hanafy Diab, Modhi Abdullah Alkamaly, Nawal Mohammed Alanazi, Ibtesam Yahia Hassan Assiry, Apsia Musa Molano, Celia Flores Baldonado, Mohamed Al-Azhary, Sharifa Al Atawi, Apsia Musa Molano, Fatima Mohammad Al Adwani, Arlu Marie Casuyon Pahilanga, Raslan Nakhla, Fatma Mohammad Al Adwani, Deepa Sasithran Nair, Grace Sindayen, Annalyn Amor Malificio, Najla Jameel Helali, Haya Barjas Al Dossari, Ashraf Kelany, Abdulmajid Ghowaizi Algethami, Leigh Yanne, Avigail Tan, Sheema Babu, Shatha Mohammad Abduljabbar, Syed Zahid Bukhari, Roaa Hasan Basri, Jeyashri Jaji Mushtaq, Hala Rushdi, Abdullah Abdulaziz Turkistani, Jerlie Mae Gonzales Celiz, Mohammed Abdullah Al Raey, Ibrahim Am Al-Zaydani Asiri, Saeed Ali Aldarani, Elizabeth Laungayan Cortez, Nadia Lynette Demaisip, Misbah Rehman Aziz, Ali Omer Abdul Aziz, Batool Al Manea, Eslam Samy, Mervat Al-Dalaton, Mohammed Jkedeb Alaliany
OBJECTIVE: To analyse the impact of the International Nosocomial Infection Control Consortium (INICC) Multidimensional Approach (IMA) and INICC Surveillance Online System (ISOS) on central line-associated bloodstream infection (CLABSI) rates in five intensive care units (ICUs) from October 2013 to September 2015. DESIGN: Prospective, before-after surveillance study of 3769 patients hospitalised in four adult ICUs and one paediatric ICU in five hospitals in five cities...
January 2017: Journal of Infection Prevention
https://www.readbyqxmd.com/read/28986277/upregulation-of-peripheral-cxc-and-cc-chemokine-receptor-expression-on-cd4-t-cells-is-associated-with-immune-dysregulation-in-children-with-autism
#5
Sheikh F Ahmad, Mushtaq A Ansari, Ahmed Nadeem, Saleh A Bakheet, Laila Yousef Al-Ayadhi, Sabry M Attia
Autism spectrum disorders (ASD) are characterized by disturbances in social interactions and communication, restricted repetitive interests, and stereotyped behavior. Cumulative evidence recommends that there are immune alterations in ASD. Chemokine receptors are known to play an important role in the central nervous system (CNS) and in many neuro inflammatory disorders. The main objective of this study was to explore the role of CXC and CC chemokine receptors signaling in children with autism. We examined chemokine receptor production of CXCR2, CXCR3, CXCR5, and CXCR7 in all peripheral blood mononuclear cells (PBMCs) and in CD4(+) T cells of typically developing control children (TD) and autistic children (AU)...
October 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28978810/interleukin-17-limits-hypoxia-inducible-factor-1%C3%AE-and-development-of-hypoxic-granulomas-during-tuberculosis
#6
Racquel Domingo-Gonzalez, Shibali Das, Kristin L Griffiths, Mushtaq Ahmed, Monika Bambouskova, Radha Gopal, Suhas Gondi, Marcela Muñoz-Torrico, Miguel A Salazar-Lezama, Alfredo Cruz-Lagunas, Luis Jiménez-Álvarez, Gustavo Ramirez-Martinez, Ramón Espinosa-Soto, Tamanna Sultana, James Lyons-Weiler, Todd A Reinhart, Jesus Arcos, Maria de la Luz Garcia-Hernandez, Michael A Mastrangelo, Noor Al-Hammadi, Reid Townsend, Joan-Miquel Balada-Llasat, Jordi B Torrelles, Gilla Kaplan, William Horne, Jay K Kolls, Maxim N Artyomov, Javier Rangel-Moreno, Joaquín Zúñiga, Shabaana A Khader
Mycobacterium tuberculosis (Mtb) is a global health threat, compounded by the emergence of drug-resistant strains. A hallmark of pulmonary tuberculosis (TB) is the formation of hypoxic necrotic granulomas, which upon disintegration, release infectious Mtb. Furthermore, hypoxic necrotic granulomas are associated with increased disease severity and provide a niche for drug-resistant Mtb. However, the host immune responses that promote the development of hypoxic TB granulomas are not well described. Using a necrotic Mtb mouse model, we show that loss of Mtb virulence factors, such as phenolic glycolipids, decreases the production of the proinflammatory cytokine IL-17 (also referred to as IL-17A)...
October 5, 2017: JCI Insight
https://www.readbyqxmd.com/read/28977399/allogeneic-mesenchymal-stem-cells-ameliorate-aging-frailty-a-phase-ii-randomized-double-blind-placebo-controlled-clinical-trial
#7
Bryon A Tompkins, Darcy L DiFede, Aisha Khan, Ana Marie Landin, Ivonne Hernandez Schulman, Marietsy V Pujol, Alan W Heldman, Roberto Miki, Pascal J Goldschmidt-Clermont, Bradley J Goldstein, Muzammil Mushtaq, Silvina Levis-Dusseau, John J Byrnes, Maureen Lowery, Makoto Natsumeda, Cindy Delgado, Russell Saltzman, Mayra Vidro-Casiano, Moisaniel Da Fonseca, Samuel Golpanian, Courtney Premer, Audrey Medina, Krystalenia Valasaki, Victoria Florea, Erica Anderson, Jill El-Khorazaty, Adam Mendizabal, Geoff Green, Anthony A Oliva, Joshua M Hare
Background: Aging frailty, characterized by decreased physical and immunological functioning, is associated with stem cell depletion. Human allogeneic mesenchymal stem cells (allo-hMSCs) exert immunomodulatory effects and promote tissue repair. Methods: This is a randomized, double-blinded, dose-finding study of intravenous allo-hMSCs (100 or 200-million [M]) vs placebo delivered to patients (n = 30, mean age 75.5 ± 7.3) with frailty. The primary endpoint was incidence of treatment-emergent serious adverse events (TE-SAEs) at 1-month postinfusion...
July 17, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28970038/cardiac-ct-in-2017-over-the-coronary-artery-assessment
#8
EDITORIAL
Daniele Andreini, Edoardo Conte, Saima Mushtaq
No abstract text is available yet for this article.
September 29, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28962008/ampc-%C3%AE-lactamase-induction-by-avibactam-and-relebactam
#9
David M Livermore, Dorota Jamrozy, Shazad Mushtaq, Wright W Nichols, Katherine Young, Neil Woodford
Background: Diazabicyclooctanes, e.g. avibactam and relebactam, are a new class of β-lactamase inhibitors. Their spectrum includes AmpC enzymes, but it is important to understand whether they also induce these enzymes. Methods: Levels of ampC mRNA were measured by RT-PCR during 4 h of exposure of Enterobacter cloacae , Citrobacter freundii and Pseudomonas aeruginosa ( n  =   5 strains per species) to avibactam, relebactam and cefoxitin at 0, 1, 4 and 32 mg/L...
September 6, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28923793/dose-comparison-study-of-allogeneic-mesenchymal-stem-cells-in-patients-with-ischemic-cardiomyopathy-the-trident-study
#10
Victoria Florea, Angela C Rieger, Darcy L Difede, Jill El-Khorazaty, Makoto Natsumeda, Monisha N Banerjee, Bryon A Tompkins, Aisha Khan, Ivonne H Schulman, Ana M Landin, Muzammil Mushtaq, Maureen H Lowery, John Byrnes, Robert C Hendel, Mauricio G Cohen, Krystalenia Valasaki, Marietsy V Pujol, Eduard Ghersin, Roberto Miki, Cindy Delgado, Fouad A Abuzeid, Mayra Vidro-Casiano, Russell Saltzman, Daniel DaFonseca, Lina V Caceres, Kevin N Ramdas, Adam Mendizabal, Alan W Heldman, Raul D Mitrani, Joshua M Hare
Rationale: Cell dose and concentration play crucial roles in phenotypic responses to cell-based therapy for heart failure. Objective: To compare the safety and efficacy of two doses of allogeneic bone marrow-derived human mesenchymal stem cells (hMSC) identically delivered in patients with ischemic cardiomyopathy (ICM). Methods and Results: Thirty patients with ICM received in a blinded manner either 20 million (20M, n=15) or 100 million (100M, n=15) allogeneic hMSCs via transendocardial injection (10 0.5 cc injections/patient)...
September 18, 2017: Circulation Research
https://www.readbyqxmd.com/read/28922646/synthesis-spectral-characterization-and-computed-optical-analysis-of-potent-triazole-based-compounds
#11
Sajjad H Sumrra, Fazila Mushtaq, Muhammad Khalid, Muhammad Asam Raza, Muhammad Faizan Nazar, Bakhat Ali, Ataualpa A C Braga
Biologically active triazole Schiff base ligand (L) and metal complexes [Fe(II), Co(II), Ni(II), Cu(II) and Zn(II)] are reported herein. The ligand acted as tridentate and coordinated towards metallic ions via azomethine-N, triazolic-N moiety and deprotonated-O of phenyl substituents in an octahedral manner. These compounds were characterized by physical, spectral and analytical analysis. The synthesized ligand and metal complexes were screened for antibacterial pathogens against Chromohalobacter salexigens, Chromohalobacter israelensi, Halomonas halofila and Halomonas salina, antifungal bioassay against Aspergillus niger and Aspergellus flavin, antioxidant (DPPH, phosphomolybdate) and also for enzyme inhibition [butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)] studies...
September 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28919015/activity-of-bacillus-thuringiensis-cry1ie2-cry2ac7-vip3aa11-and-cry7ab3-proteins-against-anticarsia-gemmatalis-chrysodeixis-includens-and-ceratoma-trifurcata
#12
Rubina Mushtaq, Robert Behle, Rongmei Liu, Lin Niu, Ping Song, Abdul Rauf Shakoori, Juan Luis Jurat-Fuentes
Transgenic soybean producing the Cry1Ac insecticidal protein from the bacterium Bacillus thuringiensis is used to control larvae of the velvetbean caterpillar (Anticarsia gemmatalis Hübner) and the soybean looper [Chrysodeixis includens (Walker)]. The main threat to the sustainability of this technology is the development of resistance, which could be delayed by using pyramiding of diverse Bt insecticidal genes. We report high activity of Cry2Ac7 and Vip3Aa11 but not Cry1Ie2 against larvae of A. gemmatalis and C...
September 14, 2017: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/28912005/proximal-radial-artery-arteriovenous-fistula-for-hemodialysis-vascular-access
#13
William C Jennings, Alexandros Mallios, Nasir Mushtaq
OBJECTIVE: This study reviewed our experience with proximal radial artery-based arteriovenous fistulas (PRA-AVFs) for hemodialysis vascular access, evaluating characteristics of the patients, functional patency, risk of steal syndrome, survival of the patient, and technical considerations. METHODS: We retrospectively analyzed our database of consecutive patients, identifying those individuals with a PRA-AVF created during a 12-year period. In addition to physical examination, all patients underwent ultrasound vessel mapping by the operating surgeon, identifying the PRA-AVF configuration and outflow target most likely to succeed...
September 11, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28900606/lymphocyte-recovery-is-an-independent-predictor-of-relapse-in-allogeneic-hematopoietic-cell-transplantation-recipients-for-acute-leukemia
#14
Moussab Damlaj, Samer Ghazi, Walid Mashaqbeh, Gamal Gmati, Hend Salama, Khadega A Abuelgasim, Mushtaq Rather, Ali Hajeer, Mohsen Al-Zahrani, Abdul-Rahman Jazieh, Ayman Alhejazi, Ahmed Alaskar
AIM: To examine the optimal absolute lymphocyte count (ALC) cut-off utilizing receiver operator characteristics (ROC) in addition to graft characteristics associated with early ALC recovery. METHODS: Patients who received T-cell replete peripheral hematopoietic cell transplantation (HCT) for acute leukemia were identified. ALC cut-off was established using ROC analysis and subsequently the cohort was stratified. Time to endpoint analysis and cox regression modelling was computed to analyze outcomes...
August 24, 2017: World Journal of Transplantation
https://www.readbyqxmd.com/read/28899512/nepeta-deflersiana-attenuates-isoproterenol-induced-myocardial-injuries-in-rats-possible-involvement-of-oxidative-stress-apoptosis-inflammation-through-nuclear-factor-nf-%C3%AE%C2%BAb-downregulation
#15
Areej Mohammad Al-Taweel, Mohammad Raish, Shagufta Perveen, Ghada Ahmed Fawzy, Ajaz Ahmad, Mushtaq Ahmad Ansari, Shahid Mudassar, Majid Ahmad Ganaie
BACKGROUND: Nepeta deflersiana (Lamiaceae) is a perennial herb used in the Saudi and Yemeni folk medicine as an anti-inflammatory, carminative, and antirheumatic agent. PURPOSE: This study explores the phytochemistry of the plant and the cardioprotective effect of N. deflersiana ethanolic extract (NDEE) against isoproterenol (ISP)-induced myocardial injury in rats. DESIGN/METHODS: Cardiac function, serum cardiac enzymes, myocardial antioxidants, inflammatory, and apoptotic biomarkers, and histopathological parameters were studied in ISP-injured Wistar rat heart tissues...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28878263/a-progesterone-brown-fat-axis-is-involved-in-regulating-fetal-growth
#16
Saraid McIlvride, Aleena Mushtaq, Georgia Papacleovoulou, Chloe Hurling, Jennifer Steel, Eugène Jansen, Shadi Abu-Hayyeh, Catherine Williamson
Pregnancy is associated with profound maternal metabolic changes, necessary for the growth and development of the fetus, mediated by reproductive signals acting on metabolic organs. However, the role of brown adipose tissue (BAT) in regulating gestational metabolism is unknown. We show that BAT phenotype is lost in murine pregnancy, while there is a gain of white adipose tissue (WAT)-like features. This is characterised by reduced thermogenic capacity and mitochondrial content, accompanied by increased levels of markers of WAT and lipid accumulation...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28867551/stable-positioning-of-unc13-restricts-synaptic-vesicle-fusion-to-defined-release-sites-to-promote-synchronous-neurotransmission
#17
Suneel Reddy-Alla, Mathias A Böhme, Eric Reynolds, Christina Beis, Andreas T Grasskamp, Malou M Mampell, Marta Maglione, Meida Jusyte, Ulises Rey, Husam Babikir, Anthony W McCarthy, Christine Quentin, Tanja Matkovic, Dominique Dufour Bergeron, Zeeshan Mushtaq, Fabian Göttfert, David Owald, Thorsten Mielke, Stefan W Hell, Stephan J Sigrist, Alexander M Walter
Neural information processing depends on precisely timed, Ca(2+)-activated synaptic vesicle exocytosis from release sites within active zones (AZs), but molecular details are unknown. Here, we identify that the (M)Unc13-family member Unc13A generates release sites and show the physiological relevance of their restrictive AZ targeting. Super-resolution and intravital imaging of Drosophila neuromuscular junctions revealed that (unlike the other release factors Unc18 and Syntaxin-1A) Unc13A was stably and precisely positioned at AZs...
September 13, 2017: Neuron
https://www.readbyqxmd.com/read/28862033/random-forest-based-evaluation-of-raman-spectroscopy-for-dengue-fever-analysis
#18
Saranjam Khan, Rahat Ullah, Asifullah Khan, Anabia Sohail, Noorul Wahab, Muhammad Bilal, Mushtaq Ahmed
This work presents the evaluation of Raman spectroscopy using random forest (RF) for the analysis of dengue fever in the infected human sera. A total of 100 dengue suspected blood samples, collected from Holy Family Hospital, Rawalpindi, Pakistan, have been used in this study. Out of these samples, 45 were dengue-positive based on immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay (ELISA) tests. For highlighting the spectral differences between normal and infected samples, an effective machine learning system is developed that automatically learns the pattern of the shift in spectrum for the dengue compared to normal cases and thus is able to predict the unknown class based on the known example...
September 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28855807/in-silico-analysis-of-glycinamide-ribonucleotide-transformylase-inhibition-by-py873-py899-and-dia
#19
Sidra Batool, Muhammad Sulaman Nawaz, Gohar Mushtaq, Fahed Parvaiz, Mohammad A Kamal
In humans, purine de novo synthesis pathway consists of multi-functional enzymes. Nucleotide metabolism enzymes are potential drug targets for treating cancer and autoimmune diseases. Glycinamide ribonucleotide transformylase (GART) is one of the most important trifunctional enzymes involved in purine synthesis. Previous studies have demonstrated the role of folate inhibitors against tumor activity. In this present study, three components of GART enzyme were targeted as receptor dataset and in silico analysis was carried out with folate ligand dataset...
September 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28842692/fe-based-hybrid-electrocatalysts-for-nonaqueous-lithium-oxygen-batteries
#20
Seun Lee, Gwang-Hee Lee, Hack Jun Lee, Mushtaq Ahmad Dar, Dong-Wan Kim
Lithium-oxygen batteries promise high energy densities, but are confronted with challenges, such as high overpotentials and sudden death during discharge-charge cycling, because the oxygen electrode is covered with the insulating discharge product, Li2O2. Here, we synthesized low-cost Fe-based nanocomposites via an electrical wire pulse process, as a hybrid electrocatalyst for the oxygen electrode of Li-O2 batteries. Fe3O4-Fe nanohybrids-containing electrodes exhibited a high discharge capacity (13,890 mA h gc(-1) at a current density of 500 mA gc(-1)), long cycle stability (100 cycles at a current rate of 500 mA gc(-1) and fixed capacity regime of 1,000 mA h gc(-1)), and low overpotential (1...
August 25, 2017: Scientific Reports
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