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https://www.readbyqxmd.com/read/28430056/greed-gullibility-and-golden-eggs-fmt-and-ethical-legal-and-practical-difficulties-regulating-transactions-in-readily-accessed-and-exchanged-bodily-products
#1
Robin Mackenzie
No abstract text is available yet for this article.
May 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28429611/consensus-statement-on-inpatient-use-of-continuous-glucose-monitoring
#2
Amisha Wallia, Guillermo E Umpierrez, Robert J Rushakoff, David C Klonoff, Daniel J Rubin, Sherita Hill Golden, Curtiss B Cook, Bithika Thompson
In June 2016, Diabetes Technology Society convened a panel of US experts in inpatient diabetes management to discuss the current and potential role of continuous glucose monitoring (CGM) in the hospital. This discussion combined with a literature review was a follow-up to a meeting, which took place in May 2015. The panel reviewed evidence on use of CGM in 3 potential inpatient scenarios: (1) the intensive care unit (ICU), (2) non-ICU, and (3) transitioning outpatient CGM use into the hospital setting. Panel members agreed that data from limited studies and theoretical considerations suggested that use of CGM in the hospital had the potential to improve patient clinical outcomes, and in particular reduction of hypoglycemia...
April 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28422805/a-randomized-pilot-study-comparing-ketamine-and-methohexital-anesthesia-for-electroconvulsive-therapy-in-patients-with-depression
#3
Shona L Ray-Griffith, Lou Ann Eads, Xiaotong Han, Kimberly Golden, Zachary N Stowe
OBJECTIVE: This randomized controlled pilot study examines the differences in response to electroconvulsive therapy (ECT) as defined by an improvement of depressive symptoms between ketamine and methohexital as the primary anesthetic agent. Adverse effects and cognitive tolerability were also examined. METHODS: Subjects undergoing ECT for unipolar or bipolar depression were randomized to receive ketamine or methohexital as the anesthetic agent. Primary outcome measure includes the Hamilton rating scale for depression (17-item)...
April 18, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28420453/golden-years-or-retirement-fears-private-pension-inequality-among-canada-s-immigrants
#4
Josh Curtis, Naomi Lightman
Currently, many immigrants are disqualified from Canada's public pension scheme because of residency requirements. In addition, decades of low income and labour market exclusion prohibit many Canadian immigrants from building adequate private pension savings throughout their working life. Together, these factors present serious concerns for immigrant seniors' economic well-being. Using Canadian census data spanning a twenty-year period (1991-2011), we find that income from personal savings plans and investments has declined sharply for both native-born and immigrant Canadians, with recent immigrant cohorts faring worst...
April 19, 2017: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/28419591/application-of-spin-echoes-in-the-regime-of-weak-dephasing-to-t1-mapping-of-the-lung
#5
Jakob Assländer, Steffen J Glaser, Jürgen Hennig
PURPOSE: This work presents an approach to mapping the entire lung's proton density and T1 within a single breath-hold and analyzes the apparent T1 when exciting with a spin echo generating pulse in comparison to a standard gradient echo acquisition. METHODS: An inversion-recovery SNAPSHOT-FLASH sequence with a stack-of-stars k-space readout with a golden angle increment was modified to use a spin echo generating radiofrequency-pulse for excitation. Data of five volunteers were acquired on a 3T scanner and image reconstruction was performed by an iterative algorithm adopted from MR-Fingerprinting...
April 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28418644/emma-an-extensible-mammalian-modular-assembly-toolkit-for-the-rapid-design-and-production-of-diverse-expression-vectors
#6
Andrea Martella, Mantas Matjusaitis, Jamie Auxillos, Steven Michael Pollard, Yizhi Cai
Mammalian plasmid expression vectors are critical reagents underpinning many facets of research across biology, biomedical research, and the biotechnology industry. Traditional cloning methods often require laborious manual design and assembly of plasmids using tailored sequential cloning steps. This process can be protracted, complicated, expensive and error-prone. New tools and strategies that facilitate the efficient design and production of bespoke vectors would help relieve a current bottleneck for researchers...
April 18, 2017: ACS Synthetic Biology
https://www.readbyqxmd.com/read/28415223/scattering-enhanced-absorption-and-interference-produce-a-golden-wing-color-of-the-burnished-brass-moth-diachrysia-chrysitis
#7
Dejan Pantelić, Svetlana Savić-Šević, Dejan V Stojanović, Srećko Ćurčić, Aleksandar J Krmpot, Mihailo Rabasović, Danica Pavlović, Vladimir Lazović, Vojislav Milošević
Here we report how interference and scattering-enhanced absorption act together to produce the golden wing patches of the burnished brass moth. The key mechanism is scattering on rough internal surfaces of the wing scales, accompanied by a large increase of absorption in the UV-blue spectral range. Unscattered light interferes and efficiently reflects from the multilayer composed of the scales and the wing membranes. The resulting spectrum is remarkably similar to the spectrum of metallic gold. Subwavelength morphology and spectral and absorptive properties of the wings are described...
March 2017: Physical Review. E
https://www.readbyqxmd.com/read/28414429/sub-lethal-lead-exposure-alters-movement-behavior-in-free-ranging-golden-eagles
#8
Frauke Ecke, Navinder J Singh, Jon M Arnemo, Anders Bignert, Björn Helander, Åsa M M Berglund, Hans Borg, Caroline Brojer, Karin Holm, Michael Lanzone, Tricia A Miller, Åke Nordström, Jannikke Raikkonen, Ilia Rodushkin, Erik Ågren, Birger Hörnfeldt
Lead poisoning of animals due to ingestion of fragments from lead-based ammunition in carcasses and offal of shot wildlife is acknowledged globally and raises great concerns about potential behavioral effects leading to increased mortality risks. Based on analyses of tracking data, we found that even sub-lethal lead concentrations in blood (25 ppb, wet weight), can likely negatively affect movement behavior (flight height and movement rate) of free-ranging scavenging Golden Eagles (Aquila chrysaetos). Lead levels in liver of recovered post-mortem analyzed eagles suggested that sub-lethal exposure increases the risk of mortality in eagles...
April 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28413853/characterization-of-the-gut-microbiota-in-the-golden-takin-budorcas-taxicolor-bedfordi
#9
Jun Chen, Huanxin Zhang, Xiaoyang Wu, Shuai Shang, Jiakuo Yan, Yao Chen, Honghai Zhang, Xuexi Tang
The gut microbiota of mammals is a complex ecosystem, which is essential for maintaining gut homeostasis and the host's health. The high throughput sequencing allowed us to gain a deeper insight into the bacterial structure and diversity. In order to improve the health status of the endangered golden takins, we first characterized the fecal microbiota of healthy golden takins using high throughput sequencing of the 16S rRNA genes V3-V4 hypervariable regions. Our results showed that, Firstly, the gut microbiota community comprised 21 phyla, 40 classes, 62 orders, 96 families, and 216 genera...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28413058/erythromelalgia-identification-of-a-corticosteroid-responsive-subset
#10
Gabriel L Pagani-Estévez, Paola Sandroni, Mark D Davis, James C Watson
BACKGROUND: Corticosteroids (CS) may benefit certain patients with erythromelalgia. OBJECTIVES: Our objective was to determine clinical predictors of corticosteroid-responsive erythromelalgia. METHODS: Patients with erythromelalgia who received CS were identified and stratified into corticosteroid nonresponders (NRs), partial corticosteroid responders (PSRs), complete corticosteroid responders (CSRs), and steroid responders (SRs = PSRs + CSRs)...
March 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28410591/eurasian-golden-jackal-as-host-of-canine-vector-borne-protists
#11
Barbora Mitková, Kristýna Hrazdilová, Gianluca D'Amico, Georg Gerhard Duscher, Franz Suchentrunk, Pavel Forejtek, Călin Mircea Gherman, Ioana Adriana Matei, Angela Monica Ionică, Aikaterini Alexandra Daskalaki, Andrei Daniel Mihalca, Jan Votýpka, Pavel Hulva, David Modrý
BACKGROUND: Jackals are medium-sized canids from the wolf-like clade, exhibiting a unique combination of ancestral morphotypes, broad trophic niches, and close phylogenetic relationships with the wolf and dog. Thus, they represent a potential host of several pathogens with diverse transmission routes. Recently, populations of the Eurasian golden jackal Canis aureus have expanded into the Western Palaearctic, including most of Europe. The aim of our study was to examine Eurasian golden jackals from Romania, Czech Republic and Austria for a wide spectrum of vector-borne protists and to evaluate the role of this species as a reservoir of disease for domestic dogs and/or humans...
April 14, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28408764/fossil-climbing-perch-and-associated-plant-megafossils-indicate-a-warm-and-wet-central-tibet-during-the-late-oligocene
#12
Feixiang Wu, Desui Miao, Mee-Mann Chang, Gongle Shi, Ning Wang
Understanding the Tibetan Plateau's palaeogeography and palaeoenvironment is critical for reconstructing Asia's climatic history; however, aspects of the plateau's uplift history remain unclear. Here, we report a fossil biota that sheds new light on these issues. It comprises a fossil climbing perch (Anabantidae) and a diverse subtropical fossil flora from the Chattian (late Oligocene) of central Tibet. The fish, Eoanabas thibetana gen. et sp. nov., is inferred to be closely related to extant climbing perches from tropical lowlands in south Asia and sub-Saharan Africa...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28408493/bio-zombie-the-rise-of-pseudoenzymes-in-biology
#13
James M Murphy, Hesso Farhan, Patrick A Eyers
Pseudoenzymes are catalytically dead counterparts of enzymes. Despite their first description some 50 years ago, the importance and functional diversity of these 'fit-for-purpose' polypeptides is only now being appreciated. Pseudoenzymes have been identified throughout all the kingdoms of life and, owing to predicted deficits in enzyme activity due to the absence of catalytic residues, have been variously referred to as pseudoenzymes, non-enzymes, dead enzymes, prozymes or 'zombie' proteins. An important goal of the recent Biochemical Society Pseudoenzymes-focused meeting was to explore the functional and evolutionary diversity of pseudoenzymes and to begin to evaluate their functions in biology, including cell signalling and metabolism...
April 15, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28408332/molecular-cloning-structural-modeling-and-expression-analysis-of-myd88-and-irak4-of-golden-pompano-trachinotus-ovatus
#14
Zhitao Qi, Baobao Sun, Qihuan Zhang, Fancui Meng, Qiaoqing Xu, Youchuan Wei, Qian Gao
MyD88 and IRAK4 are important components of TLR signaling pathways. However, information about MyD88 and IRAK4 is vacant in golden pompano (Trachinotus ovatus), a marine teleost with great commercial value. Thus, in this study the full lengths of trMyD88 and trIRAK4 were cloned from golden pompano using RT-PCR and RACE-PCR methods. trMyD88 was 1213 bp in length, encoding a putative protein of 288 amino acids (aa), consisting of a 99 aa of death domain at its N-terminal and a 137 aa of the TIR domain at its C-terminal...
April 10, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28407790/ultrastructure-and-localization-of-neorickettsia-in-adult-digenean-trematodes-provides-novel-insights-into-helminth-endobacteria-interaction
#15
Kerstin Fischer, Vasyl V Tkach, Kurt C Curtis, Peter U Fischer
BACKGROUND: Neorickettsia are a group of intracellular α proteobacteria transmitted by digeneans (Platyhelminthes, Trematoda). These endobacteria can also infect vertebrate hosts of the helminths and cause serious diseases in animals and humans. Neorickettsia have been isolated from infected animals and maintained in cell cultures, and their morphology in mammalian cells has been described. However, limited information is available on the morphology and localization of Neorickettsia in the trematode host...
April 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28407760/a-comparative-study-of-bone-biopsies-from-the-iliac-crest-the-tibial-bone-and-the-lumbar-spine
#16
Ruth G G Hiller, Margret Patecki, Claudia Neunaber, Janin Reifenrath, Jan T Kielstein, Heike Kielstein
BACKGROUND: Patients with an impaired renal function show a high incidence of bone and mineral disturbances. These 'chronic kidney disease - mineral and bone disorders' (CKD-MBD) range from high turnover osteoporosis to adynamic bone disease. Currently, the histomorphometric analysis of a bone biopsy taken from the iliac crest is viewed as the gold standard for CKD-MBD subtype differentiation. However, the clinical relevance of such a biopsy is questionable since iliac crest fractures are an extremely rare finding...
April 13, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28407043/subcons-a-new-ensemble-method-for-improved-human-subcellular-localization-predictions
#17
M Salvatore, P Warholm, N Shu, W Basile, A Elofsson
Motivation: Knowledge of the correct protein subcellular localization is necessary for understanding the function of a protein. Unfortunately large-scale experimental studies are limited in their accuracy. Therefore, the development of prediction methods has been limited by the amount of accurate experimental data. However, recently large-scale experimental studies have provided new data that can be used to evaluate the accuracy of subcellular predictions in human cells. Using this data we examined the performance of state of the art methods and developed SubCons, an ensemble method that combines four predictors using a Random Forest classifier...
April 12, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28406681/affective-enhancement-of-working-memory-is-maintained-in-depression
#18
Susanne Schweizer, Lauren Navrady, Lauren Breakwell, Rachel M Howard, Ann-Marie Golden, Aliza Werner-Seidler, Tim Dalgleish
We currently know little about how performance on assessments of working memory capacity (WMC) that are designed to mirror the concurrent task demands of daily life are impacted by the presence of affective information, nor how those effects may be modulated by depression-a syndrome where sufferers report global difficulties with executive processing. Across 3 experiments, we investigated WMC for sets of neutral words in the context of processing either neutral or affective (depressogenic) sentences, which had to be judged on semantic accuracy (Experiments 1 and 2) or self-reference (Experiment 3)...
April 13, 2017: Emotion
https://www.readbyqxmd.com/read/28405738/evaluation-of-mir-506-and-mir-4316-expression-in-early-and-non-invasive-diagnosis-of-colorectal-cancer
#19
Paweł Krawczyk, Tomasz Powrózek, Tomasz Olesiński, Adam Dmitruk, Joanna Dziwota, Dariusz Kowalski, Janusz Milanowski
PURPOSE: Examination of the entire colon by colonoscopy remains the golden standard for screening of colorectal cancer (CRC). However, patients are reluctant to perform invasive colonoscopies because of interference with their intimacy. Therefore, the potential use of non-invasive analysis of microRNAs expression in liquid biopsy as a novel biomarker for early CRC has investigated in several studies. In this study, we analyzed the expression of two novel microRNAs: miR-506 and miR-4316, which have never been examined in CRC...
April 12, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28405497/results-of-a-phase-i-ii-study-of-adjuvant-concurrent-carboplatin-and-accelerated-radiotherapy-for-triple-negative-breast-cancer
#20
Silvia C Formenti, Encouse B Golden, Judith D Goldberg, Xiaochun Li, Jessica Taff, Maria B Fenton-Kerimian, Sharanya Chandrasekhar, Sandra Demaria, Yelena Novik
Purpose: To determine feasibility and explore the clinical efficacy of concurrent radiotherapy and carboplatin as adjuvant treatment of triple negative breast cancer (TNBC). Patients and Methods: Women with Stage I-II TNBC were treated after surgery in a phase I-II prospective trial [NCT01289353]. Weekly carboplatin (AUC = 2.0) was delivered for 6 weeks. Concurrent radiotherapy was delivered in the prone position during weeks 2-4, for a total dose of 40.5 Gy in 15 fractions to the breast, and 46.5 Gy in 17 fractions to the tumor bed...
2017: Oncoimmunology
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