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Beta cells AND GSK

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https://www.readbyqxmd.com/read/27924507/tppu-protects-tau-from-h2o2-induced-hyperphosphorylation-in-hek293-tau-cells-by-regulating-pi3k-akt-gsk-3%C3%AE-pathway
#1
En-Sheng Yao, Yan Tang, Xing-Hua Liu, Ming-Huan Wang
Neurofibrillary pathology of abnormally hyperphosphorylated tau is a hallmark of Alzheimer's disease (AD) and other tauopathies. Phosphatidylinositol 3-kinase (PI3K)/Akt/glycogen synthase kinase-3 beta (GSK-3β) signaling pathway is pivotal for tau phosphorylation. Inhibition of soluble epoxide hydrolase (sEH) metabolism has been shown to effectively increase the accumulation of epoxyeicosatrienoic acids (EETs), which are cytochrome P450 metabolites of arachidonic acid and have been demonstrated to have neuroprotective effects...
December 2016: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/27907035/exendin-4-inhibits-hepatic-lipogenesis-by-increasing-%C3%AE-catenin-signaling
#2
Mi Hae Seo, Jinmi Lee, Seok-Woo Hong, Eun-Jung Rhee, Se Eun Park, Cheol Young Park, Ki Won Oh, Sung Woo Park, Won-Young Lee
The aim of this study is to investigate whether the beneficial effect of exendin-4 on hepatic steatosis is mediated by β-catenin signaling. After the HepG2 human hepatoma cells were treated with PA for 24 hours, total triglycerides levels were increased in a dose-dependent manner, and the expression levels of perilipin family members were upregulated in cells treated with 400 μM PA. For our in vitro model of hepatic steatosis, HepG2 cells were treated with 400 μM palmitic acid (PA) in the presence or absence of 100 nM exendin-4 for 24 hours...
2016: PloS One
https://www.readbyqxmd.com/read/27864906/role-and-regulation-of-glycogen-synthase-kinase-3-beta-in-bovine-spermatozoa
#3
Michael Belenky, Haim Breitbart
The serine/threonine kinase Glycogen synthase kinase 3 (GSK-3) is a master switch that regulates a multitude of cellular pathways, including the acrosome reaction in sperm. In epididymal sperm cells, for example, GSK-3 activity correlates with inhibition of motility-yet no direct pathways connecting GSK-3 activation with loss of motility have been described. Indeed, the details of how GSK-3 is regulated during sperm capacitation and the acrosome reaction remains obscure. To this end, we addressed the involvement of the GSK-3 beta isoform in several known pathways that contribute to motility and the acrosome reaction...
November 19, 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/27836781/nrf2-mediated-liver-protection-by-esculentoside-a-against-acetaminophen-toxicity-through-the-ampk-akt-gsk3%C3%AE-pathway
#4
Lidong Wang, Songling Zhang, Hang Cheng, Hongming Lv, Genhong Cheng, Xinxin Ci
Acetaminophen (APAP) overdose accounts for the majority of acute liver failure cases, and oxidative stress plays a key role in its toxic effects. Esculentoside A (EsA) has anti-oxidant activities, but its therapeutic potential for APAP hepatotoxicity remains unknown. This study aimed to assess the protective effects and mechanism of EsA against APAP-induced hepatotoxicity in vitro and in vivo. In vitro, EsA treatment inhibited APAP- or H2O2-induced cytotoxicity, H2O2 and O2(-) production, glutathione (GSH) depletion and apoptosis dependent on nuclear factor erythroid-2-related factor 2 (Nrf2) activation in HepG2 cells...
November 9, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27715343/curcumin-reduces-lung-inflammation-via-wnt-%C3%AE-catenin-signaling-in-mouse-model-of-asthma
#5
Xia Yang, Jian-Ning Lv, Hui Li, Bo Jiao, Qiu-Hong Zhang, Yong Zhang, Jie Zhang, Yan-Qin Liu, Ming Zhang, Hu Shan, Jin-Zhao Zhang, Run-Miao Wu, Ya-Li Li
OBJECTIVES: Asthma is a chronic inflammatory, heterogeneous airway disease affecting millions of people around the world. Curcumin has been found to have anti-inflammatory and antifibrosis effects. Researchers reported that curcumin regulated Wnt/β-catenin signaling in lots of cells. However, whether curcumin regulates the levels of Wnt/β-Catenin signaling in lung tissues and DCs (dendritic cells) remains unclear. In this study, we assessed the effects of curcumin on DCs and asthma...
August 15, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27612668/effects-of-mutations-in-wnt-%C3%AE-catenin-hedgehog-notch-and-pi3k-pathways-on-gsk-3-activity-diverse-effects-on-cell-growth-metabolism-and-cancer
#6
REVIEW
James A McCubrey, Dariusz Rakus, Agnieszka Gizak, Linda S Steelman, Steve L Abrams, Kvin Lertpiriyapong, Timothy L Fitzgerald, Li V Yang, Giuseppe Montalto, Melchiorre Cervello, Massimo Libra, Ferdinando Nicoletti, Aurora Scalisi, Francesco Torino, Concettina Fenga, Luca M Neri, Sandra Marmiroli, Lucio Cocco, Alberto M Martelli
Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that phosphorylated and inactivated glycogen synthase. However, subsequent studies have revealed that this moon-lighting protein is involved in numerous signaling pathways that regulate not only metabolism but also have roles in: apoptosis, cell cycle progression, cell renewal, differentiation, embryogenesis, migration, regulation of gene transcription, stem cell biology and survival...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27592306/nodal-signaling-modulates-the-expression-of-oct-4-via-nuclear-translocation-of-%C3%AE-catenin-in-lung-and-prostate-cancer-cells
#7
Yi-Fei Qi, Long Wu, Zi-Qian Li, Meng-Ling Wu, Hai-Fang Wang, Ka-Ying Chan, Lin-Lin Lu, Shao-Hui Cai, Hong-Sheng Wang, Jun Du
Nodal is a member of transforming growth factor beta (TGF-β) superfamily. Nodal promotes the self-renewal of human cancer stem cells (CSCs) and triggers carcinogenesis of human cancers via an autocrine manner through Smad2/3 pathway. In our study, generation of Nodal-overexpressed cancer cells was constructed, and the effect of Nodal on the stem cell marker Oct-4 was evaluated by overexpression or blocked Nodal/ALKs signaling pathway in non-small cell lung cancer cells A549 and prostate cancer cells PC3. Functionally, Nodal also increased the proliferation via the β-catenin nuclear translocation...
October 15, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27468552/-wnt-%C3%AE-catenin-signaling-is-involved-in-the-icariin-induced-proliferation-of-bone-marrow-mesenchymal-stem-cells
#8
Shuping Fu, Li Yang, Hao Hong, Ronghua Zhang
OBJECTIVE: To investigate the effect of icariin on proliferation of bone marrow mesenchymal stem cells (BMSCs) in Sprague-Dawley (SD) rats. METHODS: BMSCs were obtained from SD rat bone marrow with differential time adherent method. Its characteristic was identified through differentiation cell surface antigens and the multi-lineage (osteo/adipo/chondo) differentiation potential. 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and 5-Bromo-2-Deoxyuridine (BrdU) incorporation were applied to detect the effect of icariin on BMSCs proliferation...
June 2016: Journal of Traditional Chinese Medicine, Chung i Tsa Chih Ying Wen Pan
https://www.readbyqxmd.com/read/27424981/lncrna-uca1-promotes-epithelial-mesenchymal-transition-emt-of-breast-cancer-cells-via-enhancing-wnt-beta-catenin-signaling-pathway
#9
C Xiao, C-H Wu, H-Z Hu
OBJECTIVE: LncRNA UCA1 can promote invasion of breast cancer cells. However, the underlying mechanism is not quite clear. In this study, we investigated the regulative effect of UCA1 on the invasion capability of breast cancer cells and its association with the Wnt/β-catenin pathway. MATERIALS AND METHODS: Human breast cancer cell line MDA-MB-231 cells were transfected for UCA1 knockdown using UCA1 si-RNA. Transwell assay was performed to assess cell invasion capability...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27411439/environmental-factors-in-the-etiology-of-type-1-diabetes-celiac-disease-and-narcolepsy
#10
REVIEW
Åke Lernmark
The etiology of human leukocyte antigen (HLA)-associated organ-specific autoimmune diseases is incomplete. In type 1 diabetes and celiac disease, the strongest associations are with the HLA-DR3-DQ2 and DR4-DQ8 haplotypes, whereas the DQB1*06:02 allele has a strong negative association. In contrast, narcolepsy, especially as recently triggered by the Pandemrix(®) H1N1 vaccine (GlaxoKlineSmith (GSK), Brentford, Middlesex, UK), did not seem to develop without at least one copy of the latter allele. The overall hypothesis is that the role of these different HLA haplotypes, especially in Finland and Sweden, is related to the immune response to infectious agents that are common in these two populations...
July 2016: Pediatric Diabetes
https://www.readbyqxmd.com/read/27409422/14-3-3%C3%AE-and-apkc-%C3%AE-synergistically-facilitate-epithelial-mesenchymal-transition-of-cholangiocarcinoma-via-gsk-3%C3%AE-snail-signaling-pathway
#11
Yan Yang, Yan Liu, Jun-Chuang He, Jian-Ming Wang, Peter Schemmer, Chao-Qun Ma, Ya-Wei Qian, Wei Yao, Jian Zhang, Wei-Peng Qi, Yang Fu, Wei Feng, Tao Yang
Cholangiocarcinoma (CCA) invasion and metastasis are the primary causes of poor survival rates in patients. The epithelial-mesenchymal transition (EMT) is a crucial step in cancer invasion and metastasis. However, it is still unclear of the molecular mechanism. In this study, the expression of 14-3-3ζ and atypical protein kinase C-ι (aPKC-ι) was further detected in CCA tissues and cell lines. Meanwhile, we established the EMT model of CCA cells and investigated 14-3-3ζ and aPKC-ι co-regulatory effect on the EMT in vitro and in vivo...
July 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/27377891/a-metabolic-inhibitory-cocktail-for-grave-cancers-metformin-pioglitazone-and-lithium-combination-in-treatment-of-pancreatic-cancer-and-glioblastoma-multiforme
#12
REVIEW
İlhan Elmaci, Meric A Altinoz
Pancreatic cancer (PC) and glioblastoma multiforme (GBM) are among the human cancers with worst prognosis which require an urgent need for efficient therapies. Here, we propose to apply to treat both malignancies with a triple combination of drugs, which are already in use for different indications. Recent studies demonstrated a considerable link between risk of PC and diabetes. In experimental models, anti-diabetogenic agents suppress growth of PC, including metformin (M), pioglitazone (P) and lithium (L)...
October 2016: Biochemical Genetics
https://www.readbyqxmd.com/read/27374489/dihydromyricetin-protects-neurons-in-an-mptp-induced-model-of-parkinson-s-disease-by-suppressing-glycogen-synthase-kinase-3-beta-activity
#13
Zhao-Xiang Ren, Ya-Fei Zhao, Ting Cao, Xue-Chu Zhen
AIM: It is general believed that mitochondrial dysfunction and oxidative stress play critical roles in the pathology of Parkinson's disease (PD). Dihydromyricetin (DHM), a natural flavonoid extracted from Ampelopsis grossedentata, has recently been found to elicit potent anti-oxidative effects. In the present study, we explored the role of DHM in protecting dopaminergic neurons. METHODS: Male C57BL/6 mice were intraperitoneally injected with 1-methyl4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) for 7 d to induce PD...
July 4, 2016: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/27367429/antagonist-activity-of-the-antipsychotic-drug-lithium-chloride-and-the-antileukemic-drug-imatinib-mesylate-during-glioblastoma-treatment-in-vitro
#14
Yavuz Aras, Mine Erguven, Esin Aktas, Nuray Yazihan, Ayhan Bilir
OBJECTIVES: Glioblastoma (GBM), the most common primary tumour of the central nervous system, is characterised by a high malignancy and poor prognosis. The aims of this study were to investigate whether the combination of imatinib mesylate (IM) and lithium chloride (LiCl) exhibited a synergistic effect in treatment and to determine whether midkine (MK) affected the fate of this treatment in vitro. METHODS: Monolayer and spheroid cultures of the T98G human GBM cell line were treated with an IM and LiCl combination for 72 h...
September 2016: Neurological Research
https://www.readbyqxmd.com/read/27233608/a-new-glycotoxins-inhibitor-attenuates-insulin-resistance-in-liver-and-fat-cells
#15
Shabbir Khan Afridi, Meha Fatima Aftab, Munazza Murtaza, Safina Ghaffar, Aneela Karim, Uzma Rasool Mughal, Khalid Mohammed Khan, Rizwana Sanaullah Waraich
Glycotoxins/Advanced glycation end products (AGEs) have implications in development of diabetes and related diseases. In the present study we deciphered the mechanisms of action of URM-II-81, a new derivative of isatin, in alleviation of insulin resistance in human hepatocytes and murine adipocytes. URM-II-81 reduced AGEs formation and receptor for advanced glycation end products (RAGE) expression in both cell types. We also observed suppression of methylglyoxal (MGO) mediated ROS production and deactivation of PKC-α...
August 5, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27131736/neuroprotective-effects-of-honokiol-against-beta-amyloid-induced-neurotoxicity-via-gsk-3%C3%AE-and-%C3%AE-catenin-signaling-pathway-in-pc12%C3%A2-cells
#16
Yan-Fang Xian, Siu-Po Ip, Qing-Qiu Mao, Zhi-Xiu Lin
Beta-amyloid (Aβ) accumulation, one of the most important pathogenic traits of Alzheimer's disease (AD), has been reported to induce neurotoxicity in vitro as well as in vivo. Honokiol, isolated from the bark of Magnolia officinalis, has neuroprotective effects in different models of AD in vivo and in vitro. However, the exact mechanism for its neuroprotective effect is not well understood. The present study aimed to investigate the molecular mechanisms underlying the protective action of honokiol against Aβ1-42-induced neurotoxicity in cultured rat pheochromocytoma (PC12) cells...
July 2016: Neurochemistry International
https://www.readbyqxmd.com/read/27065575/intracellular-signaling-pathways-involved-in-childhood-acute-lymphoblastic-leukemia-molecular-targets
#17
REVIEW
Cristian Fabián Layton Tovar, Hugo Mendieta Zerón
Acute lymphoblastic leukemia (ALL) is a malignant disease characterized by an uncontrolled proliferation of immature lymphoid cells. ALL is the most common hematologic malignancy in early childhood, and it reaches peak incidence between the ages of 2 and 3 years. The prognosis of ALL is associated with aberrant gene expression, in addition to the presence of numerical or structural chromosomal alterations, age, race, and immunophenotype. The Relapse rate with regard to pharmacological treatment rises in childhood; thus, the expression of biomarkers associated with the activation of cell signaling pathways is crucial to establish the disease prognosis...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/27045591/enhancing-beta-catenin-activity-via-gsk3beta-inhibition-protects-pc12-cells-against-rotenone-toxicity-through-nurr1-induction
#18
Limin Zhang, Luan Cen, Shaogang Qu, Lei Wei, Mingshu Mo, Junmin Feng, Congcong Sun, Yousheng Xiao, Qin Luo, Shaomin Li, Xinling Yang, Pingyi Xu
Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic (DA) neurons in the substantial nigra pars compacta. Increasing evidence showed that Wnt/β-catenin pathway and the orphan nuclear receptor Nurr1 play crucial roles in the survival and functional maintenance of DA neurons in the midbrain and GSK-3β antagonists LiCl and SB216763 were used to activate Wnt/β-catenin pathway experimentally. However, the detail mechanism underlying the neuroprotection against apoptosis on DA neuron is still unclear and the interaction between Wnt/β-catenin and Nurr1 remains undisclosed...
2016: PloS One
https://www.readbyqxmd.com/read/27013970/characterization-of-seeding-conditions-for-studies-on-differentiation-patterns-of-subventricular-zone-derived-neurospheres
#19
Eduardo H Sanchez-Mendoza, Jana Schlechter, Dirk M Hermann, Thorsten R Doeppner
Stem cell research depends on extensive in vitro research. Poly-D-lysine (PDL) and polyornithine (PornT) are chemically synthesized amino acid chains promoting cell adhesion to solid substrates. Although, PDL and PornT are extensively used, there is no common agreement regarding the most optimal substance and its concentration. We therefore aimed at testing the effect of increasing concentrations (10, 50, and 100 μg/ml) for each compound and their corresponding mixtures (5+5 and 10+10 μg/ml) on the differentiation patterns of subventricular zone derived neurospheres...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/26983213/-mechanism-of-tanshinone-ii-a-in-inhibiting-transformation-of-aortic-valvular-myofibroblast-to-osteoblast-like-phenotype
#20
Ying-nian Shen, Wei-lin Hu, Zheng-ping Chen, Li Cai, Yong-sheng Li
Aortic valve calcification (AVC) is a pathological process correlated with multiple disease causes and actively regulated by cardiac valve cells. In this study, porcine aortic valve myofibroblasts cultured in vitro were treated with 50 μg z L(-1) of pathological factor tumor necrosis factor α (TNF-α). Tanshinone II A (TSN) with the concentration of 50 mg x L(-1) and TNF-α were combined in incubating cells for 72 h (3 d) and 120 h (5 d). The Western blotting and Real-time PCR were adopted to detect the changes in smooth muscle α actin (α-SMA), bone morphogenetic protein 2 ( BMP2), alkaline phosphatase (ALP) in cells, and expressions of key effect proteins GSK-3β and β-catenin on Wnt/β-catenin signal pathway...
September 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
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