Tomasz Tronina, Agnieszka Bartmańska, Jarosław Popłoński, Magdalena Rychlicka, Sandra Sordon, Beata Filip-Psurska, Magdalena Milczarek, Joanna Wietrzyk, Ewa Huszcza
The antiproliferative activity of xanthohumol ( 1 ), a major prenylated chalcone naturally occurring in hops, and its aurone type derivative ( Z )-6,4'-dihydroxy-4-methoxy-7-prenylaurone ( 2 ) were investigated. Both flavonoids, as well as cisplatin as a reference anticancer drug, were tested in vivo against ten human cancer cell lines (breast cancer (MCF-7, SK-BR-3, T47D), colon cancer (HT-29, LoVo, LoVo/Dx), prostate cancer (PC-3, Du145), lung cancer (A549) and leukemia (MV-4-11) and two normal cell lines (human lung microvascular endothelial (HLMEC)) and murine embryonic fibroblasts (BALB/3T3)...
April 18, 2023: International Journal of Molecular Sciences