N K Newman, Y Zhang, J Padiadpu, C L Miranda, A A Magana, C P Wong, K A Hioki, J W Pederson, Z Li, M Gurung, A M Bruce, K Brown, G Bobe, T J Sharpton, N Shulzhenko, C S Maier, J F Stevens, A F Gombart, A Morgun
BACKGROUND: The gut microbiota contributes to macrophage-mediated inflammation in adipose tissue with consumption of an obesogenic diet, thus driving the development of metabolic syndrome. There is a need to identify and develop interventions that abrogate this condition. The hops-derived prenylated flavonoid xanthohumol (XN) and its semi-synthetic derivative tetrahydroxanthohumol (TXN) attenuate high-fat diet-induced obesity, hepatosteatosis, and metabolic syndrome in C57Bl/6J mice. This coincides with a decrease in pro-inflammatory gene expression in the gut and adipose tissue, together with alterations in the gut microbiota and bile acid composition...
September 21, 2023: Microbiome