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Xanthohumol

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https://www.readbyqxmd.com/read/28036030/xanthohumol-a-prenylated-chalcone-from-hops-inhibits-the-viability-and-stemness-of-doxorubicin-resistant-mcf-7-adr-cells
#1
Ming Liu, Hua Yin, Xiaokun Qian, Jianjun Dong, Zhonghua Qian, Jinlai Miao
Xanthohumol is a unique prenylated flavonoid in hops (Humulus lupulus L.) and beer. Xanthohumol has been shown to possess a variety of pharmacological activities. There is little research on its effect on doxorubicin-resistant breast cancer cells (MCF-7/ADR) and the cancer stem-like cells exiting in this cell line. In the present study, we investigate the effect of xanthohumol on the viability and stemness of MCF-7/ADR cells. Xanthohumol inhibits viability, induces apoptosis, and arrests the cell cycle of MCF-7/ADR cells in a dose-dependent manner; in addition, xanthohumol sensitizes the inhibition effect of doxorubicin on MCF-7/ADR cells...
December 28, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27976466/fast-sampling-analyses-and-chemometrics-for-plant-breeding-bitter-acids-xanthohumol-and-terpenes-in-lupulin-glands-of-hops-humulus-lupulus
#2
Daniel P Killeen, Oliver C Watkins, Catherine E Sansom, David H Andersen, Keith C Gordon, Nigel B Perry
INTRODUCTION: The valuable secondary metabolites in hops (bitter acids, xanthohumol, volatile monoterpenes and sesquiterpenes) are sequestered in lupulin glands (extracellular trichomes) which can be collected and analysed with little or no sample preparation. OBJECTIVES: To determine whether high throughput screening of lupulin glands composition, by fast analyses and chemometrics, could be used for breeder selection of hops with key flavour attributes. METHODS: Lupulin glands from 139 plants (39 cultivars/advanced selections) were analysed by Raman and (1) H NMR spectroscopy, and head-space solid-phase microextraction (HS-SPME) GC-FID...
January 2017: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27976316/xanthohumol-and-its-derivatives-mitigate-metabolic-syndrome-and-associated-cognitive-impairments-in-obese-c57bl-6j-mice
#3
J F Stevens, L Johnson, C L Miranda, V D Elias, J J Hay, J Raber
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27938439/the-antileishmanial-activity-of-xanthohumol-is-mediated-by-mitochondrial-inhibition
#4
Lianet Monzote, Alexandra Lackova, Katrin Staniek, Silvia Steinbauer, Gerald Pichler, Walter Jäger, Lars Gille
Xanthohumol (Xan) is a natural constituent of human nutrition. Little is known about its actions on leishmanial parasites and their mitochondria as putative target. Therefore, we determined the antileishmanial activity of Xan and resveratrol (Res, as alternative compound with antileishmanial activity) with respect to mitochondria in Leishmania amazonensis promastigotes/amastigotes (LaP/LaA) in comparison with their activity in peritoneal macrophages from mouse (PMM) and macrophage cell line J774A.1 (J774). Mechanistic studies were conducted in Leishmania tarentolae promastigotes (LtP) and mitochondrial fractions isolated from LtP...
December 12, 2016: Parasitology
https://www.readbyqxmd.com/read/27923802/xanthohumol-prevents-dna-damage-by-dietary-carcinogens-results-of-a-human-intervention-trial
#5
Christoph Pichler, Franziska Ferk, Halh Al-Serori, Wolfgang Huber, Walter Jäger, Monika Waldherr, Miroslav Mišík, Michael Kundi, Armen Nersesyan, Irene Herbacek, Siegfried Knasmueller
Xanthohumol (XN) is a hop flavonoid contained in beers and soft drinks. In vitro and animal studies indicated that XN has DNA and cancer protective properties. To find out if it causes DNA protective effects in humans, an intervention trial was conducted in which the participants (n = 22) consumed a XN containing drink (12 mg XN/P/d). We monitored prevention of DNA damage induced by representatives of major groups of dietary carcinogens [i.e., nitrosodimethylamine (NDMA) benzo(a)pyrene (B(a)P) and the heterocyclic aromatic amine 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)]...
December 6, 2016: Cancer Prevention Research
https://www.readbyqxmd.com/read/27921359/modulation-of-vegf-signaling-in-a-mouse-model-of-diabetes-by-xanthohumol-and-8-prenylnaringenin-unveiling-the-angiogenic-paradox-and-metabolism-interplay
#6
Raquel Costa, Ilda Rodrigues, Luísa Guardão, Joana Quelhas Lima, Emília Sousa, Raquel Soares, Rita Negrão
SCOPE: Imbalance in kidney and heart neovascularization is common in type2 Diabetes (T2DM) patients. Nevertheless, the mechanisms governing this angiogenic paradox have not been elucidated. Xanthohumol (XN) and 8-prenylnaringenin (8PN) beer polyphenols modulate angiogenesis, being thus targets for T2DM-related complications. Our work examined whether polyphenols consumption affects angiogenic paradox and metabolism in a T2DM mouse model. METHODS AND RESULTS: An increase in kidney and a reduction in left ventricle (LV) microvessels of diabetic C57Bl/6 mice were observed...
December 6, 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27904394/dose-dependent-protective-and-inductive-effects%C3%A2-of-xanthohumol-on-oxidative-dna-damage-in%C3%A2-saccharomyces-cerevisiae
#7
Daniel O Carvalho, Rui Oliveira, Björn Johansson, Luís F Guido
The effect of xanthohumol, a prenylflavonoid isolated from the hop plant (Humulus lupulus L.), on Saccharomyces cerevisiae DNA oxidative damage and viability was evaluated. Yeast cultures under oxidative stress, induced by H2O2, displayed stronger growth in the presence of 5 mg/L of xanthohumol than cultures with only H2O2. Likewise, DNA damage assessed by the comet assay was significantly lower in cells co-incubated with xanthohumol and H2O2. Accordingly, fluorescence of dichlorofluorescein in cells treated with H2O2 and xanthohumol was considerably lower than in cells exclusively treated with H2O2, indicative of a reactive oxygen species scavenging mechanism and consequent formation of oxidation products, as detected by mass spectrometry...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27855519/xanthohumol-from-hop-cones-humulus-lupulus-l-prevents-adp-induced-platelet-reactivity
#8
Boguslawa Luzak, Hassan Kassassir, Edward Rój, Lidia Stanczyk, Cezary Watala, Jacek Golanski
Hop cones (Humulus lupulus L.), very rich source of phenolic compounds, possessing anticancer, antioxidant and anti-inflammatory activities, are considered as beneficial diet ingredients improving human health. In this study, the antiplatelet action of xanthohumol (XN), the principal flavonoid in hop cones, was investigated. XN significantly attenuated ADP-induced blood platelet aggregation (97.2 ± 35.7 AU for 6 μg/ml of XN vs. 120.4 ± 30.1 AU for 0.17% dimethyl sulfoxide (DMSO), p < 0...
November 18, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27815365/xanthohumol-modulates-calcium-signaling-in-rat-ventricular-myocytes-possible-antiarrhythmic-properties
#9
Juan Jose Arnaiz-Cot, Lars Cleemann, Martin Morad
Cardiac arrhythmia is a major cause of mortality in cardiovascular pathologies. A host of drugs targeted to sarcolemmal Na(+), Ca(2+), and K(+) channels has had limited success clinically. Recently, Ca(2+) signaling has been target of pharmacotherapy based on finding that leaky ryanodine receptors elevate local Ca(2+) concentrations causing membrane depolarizations that trigger arrhythmias. In this study, we report that xanthohumol, an antioxidant extracted from hops showing therapeutic effects in other pathologies, suppresses aberrant ryanodine receptor Ca(2+) release...
January 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27617238/hops-for-menopausal-vasomotor-symptoms-mechanisms-of-action
#10
EDITORIAL
Fatemeh Abdi, Hamid Mobedi, Nasibeh Roozbeh
Menopause is a critical stage of women's life associated with various complaints and distresses. Vasomotor symptoms (VMS), such as hot flushes, night sweats, sleep disturbances, and fatigue, are the most common menopause symptoms affecting about 50% to 80% of middle-aged women. Obviously, these symptoms, resulting from estrogen deficiency during menopause, can exert negative effects on women's health and quality of life and thus require to be managed through approaches such as hormone replacement therapy (HRT)...
August 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/27596062/conformational-modulation-of-the-farnesoid-x-receptor-by-prenylflavonoids-insights-from-hydrogen-deuterium-exchange-mass-spectrometry-hdx-ms-fluorescence-titration-and-molecular-docking-studies
#11
Liping Yang, David Broderick, Yan Campbell, Adrian F Gombart, Jan F Stevens, Yuan Jiang, Victor L Hsu, William H Bisson, Claudia S Maier
We report on the molecular interactions of the farnesoid X receptor (FXR) with prenylflavonoids, an emerging class of FXR modulators. FXR is an attractive therapeutic target for mitigating metabolic syndromes (MetS) because FXR activates the inhibitory nuclear receptor, small heterodimer partner (SHP), thereby inhibiting both gluconeogenesis and de novo lipogenesis. We and others have shown that xanthohumol (XN), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), is a FXR agonist based on its ability to affect lipid and glucose metabolism in vivo and to induces FXR target genes in biliary carcinoma cells and HEK293 cells...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27494895/hop-derived-flavonoid-xanthohumol-inhibits-endothelial-cell-functions-via-ampk-activation
#12
Cristina Gallo, Katiuscia Dallaglio, Barbara Bassani, Teresa Rossi, Armando Rossello, Douglas M Noonan, Gabriele D'Uva, Antonino Bruno, Adriana Albini
Angiogenesis, a process characterized by the formation of new blood vessels from pre-existing ones, is a crucial step in tumor growth and dissemination. Recently, increased attention has been addressed to the ability of flavonoids to prevent cancer by suppressing angiogenesis, strategy that we named "angioprevention". Several natural compounds exert their anti-tumor properties by activating 5' adenosine monophosphate-activated protein kinase (AMPK), a key regulator of metabolism in cancer cells. Drugs with angiopreventive activities, in particular metformin, regulate AMPK in endothelial cells...
September 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27487563/the-mir-204-3p-targeted-igfbp2-pathway-is-involved-in-xanthohumol-induced-glioma-cell-apoptotic-death
#13
Peng-Hsu Chen, Cheng-Kuei Chang, Chwen-Ming Shih, Chia-Hsiung Cheng, Cheng-Wei Lin, Chin-Cheng Lee, Ann-Jeng Liu, Kuo-Hao Ho, Ku-Chung Chen
Xanthohumol (XN), a prenylated chalcone extracted from hop plant Humulus lupulus L. (Cannabaceae), has potential for cancer therapy, including gliomas. Micro (mi)RNAs are small noncoding RNAs that control gene expression. Several miRNAs have been identified to participate in regulating glioma development. However, no studies have demonstrated whether miRNA is involved in XN cytotoxicity resulting in glioma cell death. This study investigated the effects of XN-mediated miRNA expression in activating apoptotic pathways in glioblastoma U87 MG cells...
November 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27392499/the-putative-role-of-transcription-factors-from-hlwrky-family-in-the-regulation-of-the-final-steps-of-prenylflavonid-and-bitter-acids-biosynthesis-in-hop-humulus-lupulus-l
#14
Jaroslav Matoušek, Tomáš Kocábek, Josef Patzak, Jindřich Bříza, Kristýna Siglová, Ajay Kumar Mishra, Ganesh Selvaraj Duraisamy, Anna Týcová, Eiichiro Ono, Karel Krofta
Lupulin glands localized in female hop (Humulus lupulus L.) cones are valuable source of bitter acids, essential oils and polyphenols. These compounds are used in brewing industry and are important for biomedical applications. In this study we describe the potential effect of transcription factors from WRKY family in the activation of the final steps of lupulin biosynthesis. In particular, lupulin gland-specific transcription factor HlWRKY1 that shows significant similarity to AtWRKY75, has ability to activate the set of promoters driving key genes of xanthohumol and bitter acids biosynthesis such as chalcone synthase H1, valerophenone synthase, prenyltransferase 1, 1L and 2 and O-methyltransferase-1...
October 2016: Plant Molecular Biology
https://www.readbyqxmd.com/read/27343844/effect-of-blending-ha-g-plla-on-xanthohumol-loaded-plga-fiber-membrane
#15
Tiankui Qiao, Suchen Jiang, Ping Song, Xiaofeng Song, Qimin Liu, Lijuan Wang, Xuesi Chen
Electropsun poly (lactide-co-glycolide) (PLGA) fiber membrane loaded xanthohumol (XN) has been developed using a co-solvent system of chloroform and dimethylformamide. To enhance its biological functionality as bone tissue engineering scaffolds, 5wt% hydroxyapatite grafted poly (l-lactic acid) (HA-g-PLLA) is blended into the spinning solution. The purpose of the present work is to disclose the effect of blending HA-g-PLLA on the corresponding properties of the medicated fiber membrane including morphology, thermodynamics, wettability, drug release, mechanics as well as cytotoxicity...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27338375/tumor-necrosis-factor-related-apoptosis-inducing-ligand-induced-apoptosis-in-prostate-cancer-cells-after-treatment-with-xanthohumol-a-natural-compound-present-in-humulus-lupulus-l
#16
Małgorzata Kłósek, Anna Mertas, Wojciech Król, Dagmara Jaworska, Jan Szymszal, Ewelina Szliszka
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is an endogenous ligand, which plays role in immune surveillance and anti-tumor immunity. It has ability to selectively kill tumor cells showing no toxicity to normal cells. We tested the apoptotic and cytotoxic activities of xanthohumol, a prenylated chalcone found in Humulus lupulus on androgen-sensitive human prostate adenocarcinoma cells (LNCaP) in combination with TRAIL. Cytotoxicity was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium reduction assay (MTT) and lactate dehydrogenase assay (LDH)...
June 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27317025/xanthohumol-inhibits-the-extracellular-signal-regulated-kinase-erk-signalling-pathway-and-suppresses-cell-growth-of-lung-adenocarcinoma-cells
#17
Adrianna Sławińska-Brych, Barbara Zdzisińska, Magdalena Dmoszyńska-Graniczka, Witold Jeleniewicz, Jacek Kurzepa, Mariusz Gagoś, Andrzej Stepulak
Aberrant activation of the Ras/MEK/ERK signaling pathway has been frequently observed in non-small-cell lung carcinoma (NSCLC) and its important role in cancer progression and malignant transformation has been documented. Hence, the ERK1/2 kinase cascade becomes a potential molecular target in cancer treatment. Xanthohumol (XN, a prenylated chalcone derived from hope cones) is known to possess a broad spectrum of chemopreventive and anticancer activities. In our studies, the MTT and BrdU assays revealed that XN demonstrated greater antiproliferative activity against A549 lung adenocarcinoma cells than against the lung adenocarcinoma H1563 cell line...
May 16, 2016: Toxicology
https://www.readbyqxmd.com/read/27269377/hop-humulus-lupulus-l-extract-and-6-prenylnaringenin-induce-p450-1a1-catalyzed-estrogen-2-hydroxylation
#18
Shuai Wang, Tareisha L Dunlap, Caitlin E Howell, Obinna C Mbachu, Emily A Rue, Rasika Phansalkar, Shao-Nong Chen, Guido F Pauli, Birgit M Dietz, Judy L Bolton
Humulus lupulus L. (hops) is a popular botanical dietary supplement used by women as a sleep aid and for postmenopausal symptom relief. In addition to its efficacy for menopausal symptoms, hops can also modulate the chemical estrogen carcinogenesis pathway and potentially protect women from breast cancer. In the present study, an enriched hop extract and the key bioactive compounds [6-prenylnarigenin (6-PN), 8-prenylnarigenin (8-PN), isoxanthohumol (IX), and xanthohumol (XH)] were tested for their effects on estrogen metabolism in breast cells (MCF-10A and MCF-7)...
July 18, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27234135/in-vitro-assays-in-natural-products-research-a-matter-of-concentration-and-relevance-to-in-vivo-administration-using-resveratrol-%C3%AE-mangostin-%C3%AE-mangostin-and-xanthohumol-as-examples
#19
C M Willson, O Grundmann
Herbal or botanical dietary supplements are an ever increasingly popular category of products in the United States and around the world. In vitro data can provide meaningful insight into the potential target and mechanism of action for a proposed active compound but may also be misused to promote a supplement to consumers with unverified health claims. In vitro data need to be considered alongside pharmacokinetic and pharmacodynamic data in preclinical animal and clinical human trials. While considerable activity of compounds and extracts in vitro may lead to further testing in vivo, in many instances, concentrations tested in cell lines or isolated targets are not achievable at the target site in vivo...
March 2017: Natural Product Research
https://www.readbyqxmd.com/read/27187329/antimicrobial-activity-of-xanthohumol-and-its-selected-structural-analogues
#20
Monika Stompor, Barbara Żarowska
The objective of this study was to evaluate the antimicrobial activity of structural analogues of xanthohumol 1, a flavonoid compound found in hops (Humulus lupulus). The agar-diffusion method using filter paper disks was applied. Biological tests performed for selected strains of Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria, fungi (Alternaria sp.), and yeasts (Rhodotorula rubra, Candida albicans) revealed that compounds with at least one hydroxyl group-all of them have it at the C-4 position-demonstrated good activity...
May 11, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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