keyword
MENU ▼
Read by QxMD icon Read
search

Xanthohumol

keyword
https://www.readbyqxmd.com/read/27904394/dose-dependent-protective-and-inductive-effects%C3%A2-of-xanthohumol-on-oxidative-dna-damage-in%C3%A2-saccharomyces-cerevisiae
#1
Daniel O Carvalho, Rui Oliveira, Björn Johansson, Luís F Guido
The effect of xanthohumol, a prenylflavonoid isolated from the hop plant (Humulus lupulus L.), on Saccharomyces cerevisiae DNA oxidative damage and viability was evaluated. Yeast cultures under oxidative stress, induced by H2O2, displayed stronger growth in the presence of 5 mg/L of xanthohumol than cultures with only H2O2. Likewise, DNA damage assessed by the comet assay was significantly lower in cells co-incubated with xanthohumol and H2O2. Accordingly, fluorescence of dichlorofluorescein in cells treated with H2O2 and xanthohumol was considerably lower than in cells exclusively treated with H2O2, indicative of a reactive oxygen species scavenging mechanism and consequent formation of oxidation products, as detected by mass spectrometry...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27855519/xanthohumol-from-hop-cones-humulus-lupulus-l-prevents-adp-induced-platelet-reactivity
#2
Boguslawa Luzak, Hassan Kassassir, Edward Rój, Lidia Stanczyk, Cezary Watala, Jacek Golanski
Hop cones (Humulus lupulus L.), very rich source of phenolic compounds, possessing anticancer, antioxidant and anti-inflammatory activities, are considered as beneficial diet ingredients improving human health. In this study, the antiplatelet action of xanthohumol (XN), the principal flavonoid in hop cones, was investigated. XN significantly attenuated ADP-induced blood platelet aggregation (97.2 ± 35.7 AU for 6 μg/ml of XN vs. 120.4 ± 30.1 AU for 0.17% dimethyl sulfoxide (DMSO), p < 0...
November 18, 2016: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/27815365/xanthohumol-modulates-calcium-signaling-in-rat-ventricular-myocytes-possible-antiarrhythmic-properties
#3
Juan Jose Arnaiz-Cot, Lars Cleemann, Martin Morad
Cardiac arrhythmia is a major cause of mortality in cardiovascular pathologies. A host of drugs targeted to sarcolemmal Na(+), Ca(2+), and K(+) channels have had limited success clinically. Recently, Ca(2+) signaling has been target of pharmacotherapy based on finding that leaky ryanodine receptors elevate local Ca(2+) concentrations causing membrane depolarizations that trigger arrhythmias. Here we report that xanthohumol, an antioxidant extracted from hops and showing therapeutic effects in other pathologies, may have antiarrhythmic properties by stabilizing ryanodine receptor's activity...
November 4, 2016: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/27617238/hops-for-menopausal-vasomotor-symptoms-mechanisms-of-action
#4
EDITORIAL
Fatemeh Abdi, Hamid Mobedi, Nasibeh Roozbeh
Menopause is a critical stage of women's life associated with various complaints and distresses. Vasomotor symptoms (VMS), such as hot flushes, night sweats, sleep disturbances, and fatigue, are the most common menopause symptoms affecting about 50% to 80% of middle-aged women. Obviously, these symptoms, resulting from estrogen deficiency during menopause, can exert negative effects on women's health and quality of life and thus require to be managed through approaches such as hormone replacement therapy (HRT)...
August 2016: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/27596062/conformational-modulation-of-the-farnesoid-x-receptor-by-prenylflavonoids-insights-from-hydrogen-deuterium-exchange-mass-spectrometry-hdx-ms-fluorescence-titration-and-molecular-docking-studies
#5
Liping Yang, David Broderick, Yan Campbell, Adrian F Gombart, Jan F Stevens, Yuan Jiang, Victor L Hsu, William H Bisson, Claudia S Maier
We report on the molecular interactions of the farnesoid X receptor (FXR) with prenylflavonoids, an emerging class of FXR modulators. FXR is an attractive therapeutic target for mitigating metabolic syndromes (MetS) because FXR activates the inhibitory nuclear receptor, small heterodimer partner (SHP), thereby inhibiting both gluconeogenesis and de novo lipogenesis. We and others have shown that xanthohumol (XN), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), is a FXR agonist based on its ability to affect lipid and glucose metabolism in vivo and to induces FXR target genes in biliary carcinoma cells and HEK293 cells...
December 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27494895/hop-derived-flavonoid-xanthohumol-inhibits-endothelial-cell-functions-via-ampk-activation
#6
Cristina Gallo, Katiuscia Dallaglio, Barbara Bassani, Teresa Rossi, Armando Rossello, Douglas M Noonan, Gabriele D'Uva, Antonino Bruno, Adriana Albini
Angiogenesis, a process characterized by the formation of new blood vessels from pre-existing ones, is a crucial step in tumor growth and dissemination. Recently, increased attention has been addressed to the ability of flavonoids to prevent cancer by suppressing angiogenesis, strategy that we named "angioprevention". Several natural compounds exert their anti-tumor properties by activating 5' adenosine monophosphate-activated protein kinase (AMPK), a key regulator of metabolism in cancer cells. Drugs with angiopreventive activities, in particular metformin, regulate AMPK in endothelial cells...
August 1, 2016: Oncotarget
https://www.readbyqxmd.com/read/27487563/the-mir-204-3p-targeted-igfbp2-pathway-is-involved-in-xanthohumol-induced-glioma-cell-apoptotic-death
#7
Peng-Hsu Chen, Cheng-Kuei Chang, Chwen-Ming Shih, Chia-Hsiung Cheng, Cheng-Wei Lin, Chin-Cheng Lee, Ann-Jeng Liu, Kuo-Hao Ho, Ku-Chung Chen
Xanthohumol (XN), a prenylated chalcone extracted from hop plant Humulus lupulus L. (Cannabaceae), has potential for cancer therapy, including gliomas. Micro (mi)RNAs are small noncoding RNAs that control gene expression. Several miRNAs have been identified to participate in regulating glioma development. However, no studies have demonstrated whether miRNA is involved in XN cytotoxicity resulting in glioma cell death. This study investigated the effects of XN-mediated miRNA expression in activating apoptotic pathways in glioblastoma U87 MG cells...
November 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27392499/the-putative-role-of-transcription-factors-from-hlwrky-family-in-the-regulation-of-the-final-steps-of-prenylflavonid-and-bitter-acids-biosynthesis-in-hop-humulus-lupulus-l
#8
Jaroslav Matoušek, Tomáš Kocábek, Josef Patzak, Jindřich Bříza, Kristýna Siglová, Ajay Kumar Mishra, Ganesh Selvaraj Duraisamy, Anna Týcová, Eiichiro Ono, Karel Krofta
Lupulin glands localized in female hop (Humulus lupulus L.) cones are valuable source of bitter acids, essential oils and polyphenols. These compounds are used in brewing industry and are important for biomedical applications. In this study we describe the potential effect of transcription factors from WRKY family in the activation of the final steps of lupulin biosynthesis. In particular, lupulin gland-specific transcription factor HlWRKY1 that shows significant similarity to AtWRKY75, has ability to activate the set of promoters driving key genes of xanthohumol and bitter acids biosynthesis such as chalcone synthase H1, valerophenone synthase, prenyltransferase 1, 1L and 2 and O-methyltransferase-1...
October 2016: Plant Molecular Biology
https://www.readbyqxmd.com/read/27343844/effect-of-blending-ha-g-plla-on-xanthohumol-loaded-plga-fiber-membrane
#9
Tiankui Qiao, Suchen Jiang, Ping Song, Xiaofeng Song, Qimin Liu, Lijuan Wang, Xuesi Chen
Electropsun poly (lactide-co-glycolide) (PLGA) fiber membrane loaded xanthohumol (XN) has been developed using a co-solvent system of chloroform and dimethylformamide. To enhance its biological functionality as bone tissue engineering scaffolds, 5wt% hydroxyapatite grafted poly (l-lactic acid) (HA-g-PLLA) is blended into the spinning solution. The purpose of the present work is to disclose the effect of blending HA-g-PLLA on the corresponding properties of the medicated fiber membrane including morphology, thermodynamics, wettability, drug release, mechanics as well as cytotoxicity...
October 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27338375/tumor-necrosis-factor-related-apoptosis-inducing-ligand-induced-apoptosis-in-prostate-cancer-cells-after-treatment-with-xanthohumol-a-natural-compound-present-in-humulus-lupulus-l
#10
Małgorzata Kłósek, Anna Mertas, Wojciech Król, Dagmara Jaworska, Jan Szymszal, Ewelina Szliszka
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is an endogenous ligand, which plays role in immune surveillance and anti-tumor immunity. It has ability to selectively kill tumor cells showing no toxicity to normal cells. We tested the apoptotic and cytotoxic activities of xanthohumol, a prenylated chalcone found in Humulus lupulus on androgen-sensitive human prostate adenocarcinoma cells (LNCaP) in combination with TRAIL. Cytotoxicity was measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium reduction assay (MTT) and lactate dehydrogenase assay (LDH)...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27317025/xanthohumol-inhibits-the-extracellular-signal-regulated-kinase-erk-signalling-pathway-and-suppresses-cell-growth-of-lung-adenocarcinoma-cells
#11
Adrianna Sławińska-Brych, Barbara Zdzisińska, Magdalena Dmoszyńska-Graniczka, Witold Jeleniewicz, Jacek Kurzepa, Mariusz Gagoś, Andrzej Stepulak
Aberrant activation of the Ras/MEK/ERK signaling pathway has been frequently observed in non-small-cell lung carcinoma (NSCLC) and its important role in cancer progression and malignant transformation has been documented. Hence, the ERK1/2 kinase cascade becomes a potential molecular target in cancer treatment. Xanthohumol (XN, a prenylated chalcone derived from hope cones) is known to possess a broad spectrum of chemopreventive and anticancer activities. In our studies, the MTT and BrdU assays revealed that XN demonstrated greater antiproliferative activity against A549 lung adenocarcinoma cells than against the lung adenocarcinoma H1563 cell line...
May 16, 2016: Toxicology
https://www.readbyqxmd.com/read/27269377/hop-humulus-lupulus-l-extract-and-6-prenylnaringenin-induce-p450-1a1-catalyzed-estrogen-2-hydroxylation
#12
Shuai Wang, Tareisha L Dunlap, Caitlin E Howell, Obinna C Mbachu, Emily A Rue, Rasika Phansalkar, Shao-Nong Chen, Guido F Pauli, Birgit M Dietz, Judy L Bolton
Humulus lupulus L. (hops) is a popular botanical dietary supplement used by women as a sleep aid and for postmenopausal symptom relief. In addition to its efficacy for menopausal symptoms, hops can also modulate the chemical estrogen carcinogenesis pathway and potentially protect women from breast cancer. In the present study, an enriched hop extract and the key bioactive compounds [6-prenylnarigenin (6-PN), 8-prenylnarigenin (8-PN), isoxanthohumol (IX), and xanthohumol (XH)] were tested for their effects on estrogen metabolism in breast cells (MCF-10A and MCF-7)...
July 18, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27234135/in-vitro-assays-in-natural-products-research-a-matter-of-concentration-and-relevance-to-in-vivo-administration-using-resveratrol-%C3%AE-mangostin-%C3%AE-mangostin-and-xanthohumol-as-examples
#13
C M Willson, O Grundmann
Herbal or botanical dietary supplements are an ever increasingly popular category of products in the United States and around the world. In vitro data can provide meaningful insight into the potential target and mechanism of action for a proposed active compound but may also be misused to promote a supplement to consumers with unverified health claims. In vitro data need to be considered alongside pharmacokinetic and pharmacodynamic data in preclinical animal and clinical human trials. While considerable activity of compounds and extracts in vitro may lead to further testing in vivo, in many instances, concentrations tested in cell lines or isolated targets are not achievable at the target site in vivo...
May 27, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27187329/antimicrobial-activity-of-xanthohumol-and-its-selected-structural-analogues
#14
Monika Stompor, Barbara Żarowska
The objective of this study was to evaluate the antimicrobial activity of structural analogues of xanthohumol 1, a flavonoid compound found in hops (Humulus lupulus). The agar-diffusion method using filter paper disks was applied. Biological tests performed for selected strains of Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria, fungi (Alternaria sp.), and yeasts (Rhodotorula rubra, Candida albicans) revealed that compounds with at least one hydroxyl group-all of them have it at the C-4 position-demonstrated good activity...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/26976708/xanthohumol-improves-dysfunctional-glucose-and-lipid-metabolism-in-diet-induced-obese-c57bl-6j-mice
#15
Cristobal L Miranda, Valerie D Elias, Joshua J Hay, Jaewoo Choi, Ralph L Reed, Jan F Stevens
Xanthohumol (XN) is a prenylated flavonoid found in hops (Humulus lupulus) and beer. The dose-dependent effects of XN on glucose and lipid metabolism in a preclinical model of metabolic syndrome were the focus of our study. Forty-eight male C57BL/6J mice, 9 weeks of age, were randomly divided into three XN dose groups of 16 animals. The mice were fed a high-fat diet (60% kcal as fat) supplemented with XN at dose levels of 0, 30, or 60 mg/kg body weight/day, for 12 weeks. Dietary XN caused a dose-dependent decrease in body weight gain...
June 1, 2016: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/26918635/humudifucol-and-bioactive-prenylated-polyphenols-from-hops-humulus-lupulus-cv-cascade
#16
Martino Forino, Simona Pace, Giuseppina Chianese, Laura Santagostini, Markus Werner, Christina Weinigel, Silke Rummler, Gelsomina Fico, Oliver Werz, Orazio Taglialatela-Scafati
Humulus lupulus (hop plant) has long been used in traditional medicine as a sedative and antimicrobial agent. More recently, attention has been devoted to the phytoestrogenic activity of the plant extracts as well as to the anti-inflammatory and chemopreventive properties of the prenylated chalcones present. In this study, an Italian sample of H. lupulus cv. "Cascade" has been investigated and three new compounds [4-hydroxycolupulone (6), humudifucol (7) and cascadone (8)] have been purified and identified by means of NMR spectroscopy along with four known metabolites...
March 25, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/26869767/determination-of-the-binding-mode-for-anti-inflammatory-natural-product-xanthohumol-with-myeloid-differentiation-protein-2
#17
Weitao Fu, Lingfeng Chen, Zhe Wang, Chengwei Zhao, Gaozhi Chen, Xing Liu, Yuanrong Dai, Yuepiao Cai, Chenglong Li, Jianmin Zhou, Guang Liang
It is recognized that myeloid differentiation protein 2 (MD-2), a coreceptor of toll-like receptor 4 (TLR4) for innate immunity, plays an essential role in activation of the lipopolysaccharide signaling pathway. MD-2 is known as a neoteric and suitable therapeutical target. Therefore, there is great interest in the development of a potent MD-2 inhibitor for anti-inflammatory therapeutics. Several studies have reported that xanthohumol (XN), an anti-inflammatory natural product from hops and beer, can block the TLR4 signaling by binding to MD-2 directly...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/26842182/xanthohumol-inhibits-cellular-proliferation-in-a-breast-cancer-cell-line-mda-mb231-through-an-intrinsic-mitochondrial-dependent-pathway
#18
Y B Yoo, K S Park, J B Kim, H J Kang, J H Yang, E K Lee, H Y Kim
AIMS: Xanthohumol isolated from hops has been reported to exhibit anticancer effects in diverse human cancers. However, its effect on breast cancer has not yet been clearly defined. The purpose of this study was to investigate the effects of xanthohumol on breast cancer cell proliferation. MATERIALS AND METHODS: After treatment with 5 μM, 10 μM, and 20 μM xanthohumol for 48 h, cells from the human breast cancer cell line MDA-MB-231 were studied using colony assay, flow cytometry, and western blotting...
October 2014: Indian Journal of Cancer
https://www.readbyqxmd.com/read/26840505/impact-of-xanthohumol-a-prenylated-flavonoid-from-hops-on-dna-stability-and-other-health-related-biochemical-parameters-results-of-human-intervention-trials
#19
Franziska Ferk, Miroslav Mišík, Armen Nersesyan, Christoph Pichler, Walter Jäger, Thomas Szekeres, Rodrig Marculescu, Henrik E Poulsen, Trine Henriksen, Roberto Bono, Valeria Romanazzi, Halh Al-Serori, Martin Biendl, Karl-Heinz Wagner, Michael Kundi, Siegfried Knasmüller
SCOPE: Xanthohumol (XN) is a hop flavonoid found in beers and refreshment drinks. Results of in vitro and animal studies indicate that it causes beneficial health effects due to DNA protective, anti-inflammatory, antioxidant, and phytoestrogenic properties. Aim of the present study was to find out if XN causes alterations of health-related parameters in humans. METHODS AND RESULTS: The effects of the flavonoid were investigated in a randomized crossover intervention trial (n = 22) in which the participants consumed a XN drink (12 mg XN/P/day)...
April 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/26794001/xanthohumol-inhibits-stat3-activation-pathway-leading-to-growth-suppression-and-apoptosis-induction-in-human-cholangiocarcinoma-cells
#20
Hasaya Dokduang, Puangrat Yongvanit, Nisana Namwat, Chawalit Pairojkul, Sakkarn Sangkhamanon, Mika Sakurai Yageta, Yoshinori Murakami, Watcharin Loilome
STAT3 plays a significant role in the development of cholangiocarcinoma (CCA) associated with the liver fluke (Opisthorchis viverrini; Ov). Xanthohumol (XN), a prenylated flavonoid extracted from hops, has known anticancer activity and could potentially target STAT3. The present study determined the effect of XN on STAT3, as well as ascertained its usefulness against CCA. The CCA cell proliferation at 20 µM and 50 µM of XN was shown to inhibited, while 20 µM partially inhibited IL-6-induced STAT3 activation...
April 2016: Oncology Reports
keyword
keyword
108971
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"