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https://www.readbyqxmd.com/read/28058751/allergen-immunotherapy-for-ige-mediated-food-allergy-a-systematic-review-and-meta-analysis
#1
REVIEW
Ulugbek Nurmatov, Sangeeta Dhami, Stefania Arasi, Giovanni Battista Pajno, Montserrat Fernandez-Rivas, Antonella Muraro, Graham Roberts, Cezmi Akdis, Montserrat Alvaro-Lozano, Kirsten Beyer, Carsten Bindslev-Jensen, Wesley Burks, George du Toit, Motohiro Ebisawa, Philippe Eigenmann, Edward Knol, Mika Makela, Kari Christine Nadeau, Liam O'Mahony, Nikolaos Papadopoulos, Lars K Poulsen, Cansin Sackesen, Hugh Sampson, Alexandra Santos, Ronald van Ree, Frans Timmermans, Aziz Sheikh
BACKGROUND: The European Academy of Allergy and Clinical Immunology (EAACI) is developing Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated Food Allergy. To inform the development of clinical recommendations, we sought to critically assess evidence on the effectiveness, safety and cost-effectiveness of AIT in the management of food allergy. METHODS: We undertook a systematic review and meta-analysis that involved searching nine international electronic databases for randomized controlled trials (RCTs) and non-randomized studies (NRS)...
January 6, 2017: Allergy
https://www.readbyqxmd.com/read/28049193/safety-and-efficacy-of-low-dose-oral-immunotherapy-for-hen-s-egg-allergy-in-children
#2
Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Kenichi Nagakura, Kiyotake Ogura, Motohiro Ebisawa
BACKGROUND: The minimal dose for oral immunotherapy (OIT) tolerance is unknown. We investigated the efficacy and safety of low-dose OIT with 1/32 of the volume of a whole egg. METHODS: Thirty-three children (aged ≥5 years) with egg allergies confirmed by oral food challenge against 1/32 of a heated whole egg (194 mg of egg protein) were enrolled. The OIT group ingested a scrambled egg once a day. The volume was gradually increased up to a maximum of 1/32 of a heated whole egg...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28042003/the-prevalence-of-eosinophilic-esophagitis-in-pediatric-patients-with-ige-mediated-food-allergy
#3
David A Hill, Jesse W Dudley, Jonathan M Spergel
BACKGROUND: Eosinophilic esophagitis (EoE) is an allergic inflammatory disease that is triggered by food allergens and characterized by progressive esophageal dysfunction. Recently, EoE has been identified in patients who underwent oral immunotherapy (OIT) for IgE-mediated food allergy, suggesting an association. OBJECTIVE: We sought to ascertain whether significant associations exist between IgE-mediated food allergies and EoE. METHODS: Using the analysis of electronic medical record data and manual chart review, we examined our subspecialty care network of 35,528 children and adolescents to identify and characterize patients with IgE-mediated and EoE food allergy...
December 30, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27977498/evaluation-of-pediatric-questions-on-the-orthopaedic-in-training-examination-an-update
#4
Robert F Murphy, Leah Nunez, William R Barfield, James F Mooney
BACKGROUND: Pediatric orthopaedics is tested frequently on the Orthopaedic In-Training Examination (OITE). The most recent data on the pediatrics section of the OITE were generated from content 10 years old. The purpose of this study is to assess the pediatric orthopaedic questions on the 2011 to 2014 OITE, and to compare question categories and cognitive taxonomy with previous data. METHODS: Four years (2011 to 2014) of OITE questions, answers, and references were reviewed...
December 13, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27931280/safety-profile-of-oral-immunotherapy-with-cows-milk-and-hen-egg-a-10-year-experience-in-controlled-trials
#5
Giovanni B Pajno, Lucia Caminiti, Fernanda Chiera, Giuseppe Crisafulli, Giuseppina Salzano, Stefania Arasi, Giovanni Passalacqua
BACKGROUND: Oral immunotherapy (OIT) for food allergy is gaining interest due to the favorable clinical results reported with cow's milk, hen egg and peanut. The safety of the procedure remains a critical aspect that can limit the introduction of OIT in clinical practice. OBJECTIVE: We described herein, in detail, the occurrence and characteristics of adverse events (AE) with OIT in children who participated in controlled trials at our unit. METHODS: The clinical records of 68 children who received active treatment (40 for cow's milk and 28 for hen egg) were carefully reviewed...
September 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27916627/peanut-oral-immunotherapy-decreases-ige-to-ara-h-2-and-ara-h-6-but-does-not-enhance-sensitization-to-cross-reactive-allergens
#6
Riikka Uotila, Anna Kaarina Kukkonen, Dario Greco, Anna Susanna Pelkonen, Mika Juhani Mäkelä
No abstract text is available yet for this article.
December 1, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27914210/randomized-controlled-trial-of-oral-immunotherapy-for-egg-allergy-in-japanese-patients
#7
Masayuki Akashi, Hiroki Yasudo, Masami Narita, Ichiro Nomura, Akira Akasawa, Motohiro Ebisawa, Takao Takahashi, Yukihiro Ohya
BACKGROUND: Egg allergy is one of the most common food allergies in young child. While oral immunotherapy (OIT) is not routinely recommended in current guidelines, it has been considered as a potential alternative treatment strategy. Studies on OIT for food allergies have been explored; however, no studies with control group have been reported in Japan. METHODS: The first oral food challenge test (OFC) was performed on participants before treatment to ensure the diagnosis and evaluate the threshold dose for egg by the way of double-blind, placebo-controlled food challenge (DBPCFC)...
December 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27913305/oral-immunotherapy-induced-gastrointestinal-symptoms-and-peripheral-blood-eosinophil-responses
#8
Michael R Goldberg, Arnon Elizur, Liat Nachshon, Michael Y Appel, Michael B Levy, Keren Golobov, Robert Goldberg, Miguel Stein, Marc E Rothenberg, Yitzhak Katz
No abstract text is available yet for this article.
November 29, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27886011/odor-identification-screening-improves-diagnostic-classification-in-incipient-alzheimer-s-disease
#9
Megan Quarmley, Paul J Moberg, Dawn Mechanic-Hamilton, Sushila Kabadi, Steven E Arnold, David A Wolk, David R Roalf
BACKGROUND: Measurements of olfaction may serve as useful biomarkers of incipient dementia. Here we examine the improvement in diagnostic accuracy of Alzheimer's disease (AD) and mild cognitive impairment (MCI) when assessing both cognitive functioning and odor identification. OBJECTIVE: To determine the utility of odor identification as a supplementary screening test in incipient AD. METHODS: Sniffin' Sticks Odor Identification Test (SS-OIT) and the Montreal Cognitive Assessment (MoCA) were administered in 262 AD, 174 MCI [150 amnestic (aMCI), and 24 non-amnestic (naMCI)], and 292 healthy older adults (HOA)...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27862003/occurrence-and-concentrations-of-isothiazolinones-in-detergents-and-cosmetics-in-switzerland
#10
Elena Garcia-Hidalgo, Virginie Sottas, Natalie von Goetz, Urs Hauri, Christian Bogdal, Konrad Hungerbühler
BACKGROUND: In recent years, the frequency of contact allergy to isothiazolinones has increased alarmingly in Europe, but only limited data are available on concentrations of isothiazolinones in consumer products. OBJECTIVES: To examine the current frequency of isothiazolinones [methylisothiazolinone (MI), methylchloroisothiazolinone (MCI), benzisothiazolinone (BIT), and octylisothiazolinone (OIT)] in a wide array of detergents and cosmetics relevant for the Swiss population...
February 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/27859599/double-blind-placebo-controlled-challenge-showed-that-peanut-oral-immunotherapy-was-effective-for-severe-allergies-without-negative-effects-on-airway-inflammation
#11
Anna Kaarina Kukkonen, Riikka Uotila, Leo Pekka Malmberg, Anna Susanna Pelkonen, Mika Juhani Mäkelä
AIM: This study examined the efficacy and the safety of peanut oral immunotherapy (OIT). METHODS: We recruited 60 patients aged 6-18 years who had a moderate-to-severe reaction to a double-blind placebo-controlled peanut challenge: 39 received OIT during an eight-month build-up phase and maintenance phase and 21 controls avoided peanuts. We measured specific immunoglobulin E and G4 (IgE and IgG4) to peanuts and to Ara h 1, 2, 3, 8, and 9 and monitored adverse events, bronchial hyperresponsiveness (BHR) to methacholine and fractional concentrations of exhaled nitric oxide (FeNO)...
November 12, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27826960/oral-food-desensitization-in-children-with-ige-mediated-cow-s-milk-allergy-immunological-changes-underlying-desensitization
#12
Laura Perezábad, Marta Reche, Teresa Valbuena, Rosina López-Fandiño, Elena Molina, Iván López-Expósito
PURPOSE: This study aimed to evaluate the safety and efficacy to induce clinical desensitization to cow's milk (CM) of an oral immunotherapy (OIT) protocol in a pediatric population with cow's milk allergy (CMA). In addition, the immune responses against β-casein, of peripheral blood mononuclear cells (PBMCs) from CMA patients, before and after the protocol were evaluated and compared to a nonallergic population. METHODS: A group of 20 children with IgE-mediated CMA and 15 nonallergic children were recruited...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27738689/thermal-oxidative-and-ozone-oxidative-stabilization-effect-of-hybridized-functional-graphene-oxide-in-a-silica-filled-solution-styrene-butadiene-elastomer
#13
Juqiao Su, Zhongguo Zhao, Yajiang Huang, Xia Liao, Qi Yang
Hybridization of modified functional graphene oxide (fGO) in silica-filled solution styrene butadiene rubber (SSBR) endows preferable tensile and dynamic properties before and after thermal oxidative aging, and similar mechanical hysteresis performance compared with the composites without fGO. The preventing mechanism of fGO is attributed to its intrinsic peroxy radical scavenging and gas barrier abilities, which significantly reduces the peroxy radical concentration and oxygen permeability of nanocomposites and then prolongs oxidative induction time (OIT), characterized by differential scanning calorimetry (DSC)...
October 14, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27722345/a-mechanistic-study-of-manganese-iii-acetate-mediated-phosphonyl-group-additions-to-60-and-70-fullerenes-the-oxidative-ion-transfer-mechanism-vs-free-radical-addition
#14
Boris L Tumanskii, Denis S Sabirov, Yury I Lyakhovetsky
The phosphonylation of C60 with HP(O)(OAlk)2 and Mn(OAc)3·2H2O has been considered to occur via a free radical (FR) path involving intermediate radicals ˙P(O)(OAlk)2. The present study provides evidence in support of another mechanism for the reactions, oxidative-ion-transfer (OIT). The mechanism involves the change of an acetate group in Mn(OAc)3 for the phosphonate group and oxidation of C60 by the Mn(OAc)2P(O)(OAlk)2 formed to a pair: (C60˙(+), Mn(OAc)2P(O)(OAlk)2˙(-)) followed by the transfer of the phosphonate anion to give the monophposphonylfullerenyl radical...
September 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27628022/the-use-of-omalizumab-in-food-oral-immunotherapy
#15
Roxane Labrosse, François Graham, Anne Des Roches, Philippe Bégin
Food allergy is an important health issue that affects up to 8 % of the population. The management of allergic patients involves allergen avoidance and prompts the treatment of accidental reactions, as no curative treatment is available so far in routine practice. Oral immunotherapy (OIT) is a promising therapeutic alternative, but it is associated with frequent allergic reactions and cost-effectiveness issues. In hopes of reducing such reactions, a number of trials have used omalizumab, an anti-IgE monoclonal humanized antibody, as adjunctive therapy in OIT...
September 14, 2016: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/27609658/omalizumab-facilitates-rapid-oral-desensitization-for-peanut-allergy
#16
Andrew J MacGinnitie, Rima Rachid, Hana Gragg, Sara V Little, Paul Lakin, Antonella Cianferoni, Jennifer Heimall, Melanie Makhija, Rachel Robison, R Sharon Chinthrajah, John Lee, Jennifer Lebovidge, Tina Dominguez, Courtney Rooney, Megan Ott Lewis, Jennifer Koss, Elizabeth Burke-Roberts, Kimberly Chin, Tanya Logvinenko, Jacqueline A Pongracic, Dale T Umetsu, Jonathan Spergel, Kari C Nadeau, Lynda C Schneider
BACKGROUND: Peanut oral immunotherapy is a promising approach to peanut allergy, but reactions are frequent, and some patients cannot be desensitized. The anti-IgE medication omalizumab (Xolair; Genentech, South San Francisco, Calif) might allow more rapid peanut updosing and decrease reactions. OBJECTIVE: We sought to evaluate whether omalizumab facilitated rapid peanut desensitization in highly allergic patients. METHODS: Thirty-seven subjects were randomized to omalizumab (n = 29) or placebo (n = 8)...
September 5, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27609653/novel-baseline-predictors-of-adverse-events-during-oral-immunotherapy-in-children-with-peanut-allergy
#17
Yamini V Virkud, A Wesley Burks, Pamela H Steele, Lloyd J Edwards, Jelena P Berglund, Stacie M Jones, Amy M Scurlock, Tamara T Perry, Robert D Pesek, Brian P Vickery
BACKGROUND: Though peanut oral immunotherapy (OIT) is a promising investigational therapy, its potential is limited by substantial adverse events (AEs), which are relatively understudied. OBJECTIVE: A retrospective analysis was conducted, pooling data from 3 pediatric peanut OIT trials, comprising the largest analysis of peanut OIT safety to date. METHODS: We pooled data from 104 children with peanut allergy from 3 peanut OIT studies. We catalogued AEs from parental reports, daily symptom diaries, and dose escalations...
September 5, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27592279/primary-eosinophilic-gastrointestinal-disorders-in-children-who-have-received-food-oral-immunotherapy
#18
L Á Echeverría-Zudaire, S Fernández-Fernández, A Rayo-Fernández, C Muñóz-Archidona, R Checa-Rodriguez
BACKGROUND: Food oral immunotherapy (OIT) involves the administration of the food allergen causing the symptoms, in order to induce tolerance. Primary eosinophilic gastrointestinal disorders (PEGDs) are characterised by an eosinophil-rich inflammation affecting different locations of the digestive tract. We present a series of patients with PEGDs in a group of children following OIT with milk and/or egg. MATERIAL AND METHODS: A prospective study during the period 2006-2014 was performed in paediatric patients subjected to OIT with milk and/or egg...
November 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27570533/two-weeks-sustained-unresponsiveness-by-oral-immunotherapy-using-microwave-heated-cow-s-milk-for-children-with-cow-s-milk-allergy
#19
Masaya Takahashi, Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Sohsaku Yamanouchi, Kazuanri Kaneko
BACKGROUND: Several studies have reported that oral immunotherapy (OIT) is effective for children with cow's milk (CM) allergy. These studies reported the efficacy of OIT in terms of desensitization, but did not describe sustained unresponsiveness to CM. The aim of this study was to evaluate the efficacy of the OIT protocol using microwave heated cow's milk (MH-CM) in terms of 2-weeks-sustained unresponsiveness (2-weeks-SU) and safety. METHODS: Forty-eight children were enrolled in this study...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27569751/levels-of-evidence-for-foot-and-ankle-questions-on-the-orthopaedic-in-training-examination-15-year-trends
#20
Cory T Walsh, Louis C Grandizio, Joel C Klena, John M Parenti, Gerard J Cush
BACKGROUND: The foot and ankle (FA) content domain is a component of the orthopaedic in-training examination (OITE). Levels of evidence (LoE) have been infrequently studied on the OITE. The purpose of this study is to determine if LoE for primary journal articles referenced for FA questions increased over a 15-year period. We also aim to determine if reference characteristics and question taxonomy have changed during this period. METHODS: All 132 questions and 261 references in the FA content domain from 1995 to 1997 and from 2010 to 2012 were included...
November 2016: Journal of Surgical Education
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