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https://www.readbyqxmd.com/read/29132677/adjuvant-therapies-in-food-immunotherapy
#1
REVIEW
Wenyin Loh, Mimi Tang
Finding an effective curative treatment for food allergy is a research priority. Although oral immunotherapy (OIT) is effective at inducing desensitization, the temporary nature of this effect and high rates of adverse reactions have highlighted a need for novel strategies to improve tolerance induction and safety. One such strategy is the use of an adjuvant together with food immunotherapy to either suppress allergic reactions and/or modulate the underlying allergic immune response. In particular, the use of bacterial adjuvants seems to be a promising means of enhancing OIT-induced sustained unresponsiveness and warrants further investigation...
February 2018: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/29075389/aligning-in-service-training-examinations-in-plastic-surgery-and-orthopaedic-surgery-with-competency-based-education
#2
Nishant Ganesh Kumar, Michael A Benvenuti, Brian C Drolet
BACKGROUND : In-service training examinations (ITEs) are used to assess residents across specialties. However, it is not clear how they are integrated with the Accreditation Council for Graduate Medical Education Milestones and competencies. OBJECTIVE : This study explored the distribution of specialty-specific milestones and competencies in ITEs for plastic surgery and orthopaedic surgery. METHODS : In-service training examinations were publicly available for plastic surgery (PSITE) and orthopaedics (OITE)...
October 2017: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/29070273/oral-immunotherapy-in-children-with-ige-mediated-hen-s-egg-allergy-follow-ups-at-2-5-and-7-years
#3
Paolo Meglio, Paolo Gianni Giampietro, Rossella Carello, Elena Galli
BACKGROUND: The present report was a follow-up investigation at 2.5- and 7-year intervals of a previous study of 20 children with moderate-to-severe immunoglobulin E (IgE) mediated hen's egg (HE) allergy who received oral immunotherapy (OIT) with raw HE. The study design of the previous study divided the 20 subjects into two groups of 10 each: (1) group 1, the OIT group (OIT-G), and, (2) group 2, an age-matched control group (C-G). In that study, 8 of 10 of the children in the OIT-G were successfully desensitized, one child was partially desensitized, and desensitization failed in one child...
October 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/29053905/distinct-predictive-role-of-collateral-status-on-clinical-outcome-in-variant-stroke-subtypes-of-acute-large-arterial-occlusion
#4
Xuting Zhang, Meixia Zhang, Wenhong Ding, Shenqiang Yan, David S Liebeskind, Min Lou
BACKGROUND: Clinical trials have showed that robust collateral flow has a relationship with good clinical outcome, however, different stroke subtypes were lumped together. This study explored the relationship between baseline collaterals and the onset-to-imaging time (OIT), and the correlation between pre-treatment collateral status and clinical outcome among different subtypes. METHOD: We reviewed prospectively collected data from consecutive acute ischemic stroke (AIS) patients with acute middle cerebral artery occlusion who received reperfusion therapy...
October 20, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29033945/improved-efficacy-of-oral-immunotherapy-using-non-digestible-oligosaccharides-in-a-murine-cow-s-milk-allergy-model-a-potential-role-for-foxp3-regulatory-t-cells
#5
Marlotte M Vonk, Mara A P Diks, Laura Wagenaar, Joost J Smit, Raymond H H Pieters, Johan Garssen, Betty C A M van Esch, Léon M J Knippels
BACKGROUND: Oral immunotherapy (OIT) is a promising therapeutic approach to treat food allergic patients. However, there are some concerns regarding its safety and long-term efficacy. The use of non-digestible oligosaccharides might improve OIT efficacy since they are known to directly modulate intestinal epithelial and immune cells in addition to acting as prebiotics. AIM: To investigate whether a diet supplemented with plant-derived fructo-oligosaccharides (FOS) supports the efficacy of OIT in a murine cow's milk allergy model and to elucidate the potential mechanisms involved...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29028118/elevated-serum-adipsin-may-predict-unsuccessful-treatment-for-cows-milk-allergy-but-other-biomarkers-do-not
#6
Susanna Salmivesi, Marita Paassilta, Heini Huhtala, Riina Nieminen, Eeva Moilanen, Matti Korppi
AIM: This study evaluated whether 15 allergy, immunology or inflammatory markers predicted the long-term use of cows' milk or milk products seven years after the start of oral immunotherapy (OIT) for cows' milk allergy in children. METHODS: The following laboratory parameters were measured before the OIT at Tampere University Hospital, Finland, and after the six-month escalation phase: serum total immunoglobulin (Ig) E, milk-specific IgG and IgG4, eosinophil cationic protein, eosinophil-derived neurotoxin, interleukins 4, 5, 6,10 and 12p70 and serum adipokines adiponectin, adipsin, leptin and resistin...
October 13, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29021893/the-efficacy-of-oral-and-subcutaneous-antigen-specific-immunotherapy-in-murine-cow-s-milk-and-peanut-allergy-models
#7
Marlotte M Vonk, Laura Wagenaar, Raymond H H Pieters, Leon M J Knippels, Linette E M Willemsen, Joost J Smit, Betty C A M van Esch, Johan Garssen
BACKGROUND: Antigen-specific immunotherapy (AIT) is a promising therapeutic approach for both cow's milk allergy (CMA) and peanut allergy (PNA), but needs optimization in terms of efficacy and safety. AIM: Compare oral immunotherapy (OIT) and subcutaneous immunotherapy (SCIT) in murine models for CMA and PNA and determine the dose of allergen needed to effectively modify parameters of allergy. METHODS: Female C3H/HeOuJ mice were sensitized intragastrically (i...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28959122/oral-immunotherapy-with-partially-hydrolyzed-wheat-based-cereals-a-pilot-study
#8
Roger Lauener, Philippe A Eigenmann, Jacqueline Wassenberg, Andreas Jung, Sandra Denery-Papini, Sigrid Sjölander, Sophie Pecquet, Rodolphe Fritsché, Adrian Zuercher, Antoine Wermeille, Massimo Fontanesi, Annick Mercenier, Yvonne M Vissers, Sophie Nutten
To date, only few studies have assessed oral immunotherapy (OIT) for wheat allergy and often describe severe adverse reactions during therapy. We developed partially hydrolyzed wheat-based cereals (pHC), which were used in a multicenter, open-label, OIT pilot study, in immunoglobulin E-mediated wheat allergy children (NCT01332084). The primary objective of the study was to test whether wheat allergic patients tolerate pHC and primary end point was the presence or not of immediate adverse reactions to pHC during the 1-day initial escalation phase (stepwise increased doses of pHC), with evaluation of the maximum dose tolerated...
2017: Clinical Medicine Insights. Pediatrics
https://www.readbyqxmd.com/read/28895784/immunotherapy-for-ige-mediated-wheat-allergy
#9
P Pacharn, P Vichyanond
Among various routes of immunotherapy for food allergy, oral immunotherapy (OIT) appears to have a promising result due to its ability to modify abnormal immunologic mechanism of IgE-mediated food allergy. Other methods for immunomodulation such as sublingual (SLIT) or epicutaneous (EPIT) immunotherapy which carry lower rates of systemic reactions, may have less efficacy. Wheat has recently been recognized as a more common cause of food-induced anaphylaxis than previously recognized, especially among young children, around the world...
October 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28890372/thermal-oxidative-effect-of-kraft-lignin-antioxidant-in-polypropylene-uncovering-the-key-factor-using-correlation-analysis-model
#10
Kai Chen, Dezhan Ye, Shaojin Gu, Yingshan Zhou
Which factors are crucial to improving lignin antioxidant ability in polymers has been debated over years. Here, the structural effect of natural antioxidant from technical Kraft lignin (KL) on the oxidation induction time (OIT) of KL/polypropylene (PP) was quantitatively investigated using correlation analysis model instead of traditional linear fitting model. The correlation coefficient and significance value of their relationship clearly demonstrated the dominating role of non-condensed Phenolic OH (Ph-OH) in improving KL/PP thermal-oxidation stability, subsequently followed by M¯n, aliphatic OH/total Ph-OH, condensed Ph-OH and polydispersity...
September 7, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28846472/the-current-state-of-food-allergy-therapeutics
#11
Meng Chen, Michael Land
The prevalence of IgE mediated food allergy is an increasing public health concern. The current standard of treatment is strict avoidance of the offending food(s). There are no FDA approved treatments for food allergy. This review will provide an overview of strategies currently under investigation for the treatment of food allergy. The main focus of research has been directed at various forms of immunotherapy, including oral, sublingual and epicutaneous delivery routes. While oral immunotherapy (OIT) has shown the greatest promise for efficacy in terms of amount of protein that can be ingested, it has also demonstrated less tolerability and a less favorable safety profile as compared to sublingual immunotherapy (SLIT) and epicutaneous immunotherapy (EPIT), which offers the least protection but has the best safety and tolerability profile...
October 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28825866/immunotherapy-for-cow-s-milk-allergy
#12
Shoichiro Taniuchi, Masaya Takahashi, Kazukiko Soejima, Yasuko Hatano, Hirotaka Minami
Oral immunotherapy (OIT) is used regularly for young children with cow's milk (CM) allergy and has been shown to be effective in several studies. However, adverse events occur frequently during OIT. Furthermore, there are only 5 randomized controlled trial studies of CM-OIT and these are low-powered single center trials. Therefore, evidence levels are also low and sometimes frequent and severe allergic events occur during the OIT. Furthermore, there are no standardized protocols in pediatric allergy guidelines from several countries and studies with long-term follow-up observations and clinical tolerance defined as sustained unresponsiveness are rare...
October 3, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28816320/formation-of-titanium-dioxide-core-shell-microcapsules-through-a-binary-phase-spray-technique
#13
Jonatan Bergek, Björn Elgh, Anders E C Palmqvist, Lars Nordstierna
Core-shell microcapsules consisting of a titanium dioxide shell and a hydrophobic solvent core have been prepared with diameters of a few micrometers and a narrow size distribution using a simple and fast airbrush technique. These microcapsules were prepared at room temperature in a single-step process in which an oil with a dissolved titanium alkoxide precursor was forced together with an aqueous solution, containing a surface-active polymer, through a narrow spray nozzle using a nitrogen gas propellant. Several different parameters of chemical, physical, and processing origin were investigated to find an optimal recipe...
September 13, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28812470/oral-administration-of-ovalbumin-after-sensitization-attenuates-symptoms-in-a-mouse-model-of-food-allergic-enteropathy
#14
Erika Hiraide, Mamiko Morinaga, Hiroki Hidaka, Satoki Yamada, Jun Takeyama, Noriko Kitamura, Osamu Kaminuma, Takachika Hiroi, Weibin Du, Katsuyo Ohashi-Doi, Haruyo Nakajima-Adachi, Satoshi Hachimura
Oral immunotherapy (OIT) is a promising treatment of food allergy. To administer an appropriate oral dose of an allergenic component as OIT to individuals sensitized with a food allergen may prevent inducing food allergic inflammation in them. So we attempted to establish a mouse model to evaluate efficacy for oral administration of food allergen after sensitization. In BALB/c mice sensitized by injecting ovalbumin (OVA) with alum twice, OVA was administered before inducing inflammation by feeding the mice with egg white (EW) diet...
October 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28802720/application-of-green-fluorescent-protein-to-measure-antimicrobial-efficacy-and-the-kinetics-of-cell-death-against-escherichia-coli
#15
Richard Greenhalgh, Malcolm Greenhalgh, Fadwa Alshareef, Geoffrey D Robson
Industrial antimicrobials have been extensively used to control unwanted microbial growth by incorporation into a variety of products such as plastics and paints, reducing biodeterioration and biofouling and extending the lifespan of the product. Industrial antimicrobials generally have broad sites of action affecting core cellular functions such as central metabolism, enzyme function, cell wall or DNA synthesis and can either be biocidal or biostatic. In addition, susceptibility can be affected by the metabolic state of the microbe, with metabolically inactive cells generally more resistant than metabolically active cells...
August 10, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28782296/combining-anti-ige-with-oral-immunotherapy
#16
REVIEW
Chunrong Lin, Ivan T Lee, Vanitha Sampath, Chitra Dinakar, Rosemarie H DeKruyff, Lynda C Schneider, Kari Christine Nadeau
Food allergy is a significant medical problem that affects up to 8% of children in developed countries. At present, there are no curative therapies available in routine practice and management of food allergy involves strict allergen avoidance, education, and prompt treatment upon accidental exposure. Oral immunotherapy (OIT) is an efficacious experimental approach to food allergy and has been shown to provide a substantial benefit in terms of allergen desensitization. However, OIT is associated with high rates of allergic reactions, and the period of protection offered by OIT appears to be limited and highly variable...
August 7, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28780220/clinical-aspects-of-oral-immunotherapy-for-the-treatment-of-allergies
#17
REVIEW
Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa
Studies on oral immunotherapy (OIT) have been increasing worldwide. Nevertheless, some concerns exist with this treatment. The rate of long-term sustained unresponsiveness is quite low; moreover, the desensitization or sustained unresponsiveness does not equate to tolerance. Furthermore, adverse reactions are frequent. Therefore, safe and feasible methods for long-term therapies are needed. Novel therapies such as low-dose OIT, hypoallergenic products, and OIT in combination with omalizumab are reported as effective for inducing sustained unresponsiveness and may lead to fewer adverse reactions than standard OIT...
April 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28760498/differences-and-similarities-between-sublingual-immunotherapy-of-allergy-and-oral-tolerance
#18
REVIEW
Philippe Moingeon, Laurent Mascarell
Allergen immunotherapy is the only treatment altering the natural course of IgE-mediated allergies. Whereas the subcutaneous route for immunotherapy (SCIT) has been historically considered as a reference, we discuss herein the relative advantages of the sublingual and oral routes as alternatives to SCIT in order to elicit allergen-specific tolerance. The buccal and gut immune systems are similarly organized to favor immune tolerance to antigens/allergens, due to the presence of tolerogenic dendritic cells and macrophages promoting the differentiation of CD4(+) regulatory T cells...
April 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28752892/patterns-of-concomitant-allergic-reactions-in-patients-suggest-cross-sensitization-between-octylisothiazolinone-and-methylisothiazolinone
#19
Kristiina Aalto-Korte, Katri Suuronen
BACKGROUND: Recent animal tests have indicated cross-reactivity between methylisothiazolinone (MI), octylisothiazolinone (OIT), and benzisothiazolinone (BIT). OBJECTIVES: To retrospectively analyse concomitant reactions to different isothiazolinones in patients in an occupational dermatology clinic during the ongoing MI contact allergy epidemic. METHODS: We searched patch test files (January 2012 to February 2017) for patients with allergic reactions to OIT, BIT, and MI, and analysed their patch test results, occupations, exposure, and diagnoses...
July 28, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28731411/oral-immunotherapy-for-food-allergy-a-spanish-guideline-immunotherapy-egg-and-milk-spanish-guide-items-guide-part-i-cow-milk-and-egg-oral-immunotherapy-introduction-methodology-rationale-current-state-indications-contraindications-and-oral-immunotherapy-build
#20
REVIEW
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
BACKGROUND AND OBJECTIVE: Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available. Objectives: To develop clinical guidelines for OIT based on available scientific evidence and the opinions of experts. METHODS: A review was made of studies published between 1984 and June 2016, doctoral theses published in Spain, summaries of communications at scientific meetings (SEAIC, SEICAP, EAACI, and AAAAI), and the consensus of opinion established by a group of experts from the scientific societies SEICAP and SEAIC...
2017: Journal of Investigational Allergology & Clinical Immunology
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