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https://www.readbyqxmd.com/read/27916627/peanut-oral-immunotherapy-decreases-ige-to-ara-h-2-and-ara-h-6-but-does-not-enhance-sensitization-to-cross-reactive-allergens
#1
Riikka Uotila, Anna Kaarina Kukkonen, Dario Greco, Anna Susanna Pelkonen, Mika Juhani Mäkelä
During peanut OIT, the serological response is directed to the peanut storage proteins, especially, to the 2S albumins. No neosensitization to cross-reactive allergens emerges.
December 1, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27914210/randomized-controlled-trial-of-oral-immunotherapy-for-egg-allergy-in-japanese-patients
#2
Masayuki Akashi, Hiroki Yasudo, Masami Narita, Ichiro Nomura, Akira Akasawa, Motohiro Ebisawa, Takao Takahashi, Yukihiro Ohya
BACKGROUND: Egg allergy is one of the most common food allergies in young child. While oral immunotherapy (OIT) is not routinely recommended in current guidelines, it has been considered as a potential alternative treatment strategy. Studies on OIT for food allergies have been explored; however, no studies with control group have been reported in Japan. METHODS: The first oral food challenge test (OFC) was performed on participants before treatment to ensure the diagnosis and evaluate the threshold dose for egg by the way of double-blind, placebo-controlled food challenge (DBPCFC)...
December 3, 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27913305/oral-immunotherapy-induced-gastrointestinal-symptoms-and-peripheral-blood-eosinophil-responses
#3
Michael R Goldberg, Arnon Elizur, Liat Nachshon, Michael Y Appel, Michael B Levy, Keren Golobov, Robert Goldberg, Miguel Stein, Marc E Rothenberg, Yitzhak Katz
Oral immunotherapy-induced gastrointestinal and eosinophilic responses (OITIGER) is an adverse response to OIT in ∼8% of patients and is typically reversible by decreasing dosage administration. The peripheral blood eosinophil count serves as a biomarker marker for susceptibility and the medical course.
November 29, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27886011/odor-identification-screening-improves-diagnostic-classification-in-incipient-alzheimer-s-disease
#4
Megan Quarmley, Paul J Moberg, Dawn Mechanic-Hamilton, Sushila Kabadi, Steven E Arnold, David A Wolk, David R Roalf
BACKGROUND: Measurements of olfaction may serve as useful biomarkers of incipient dementia. Here we examine the improvement in diagnostic accuracy of Alzheimer's disease (AD) and mild cognitive impairment (MCI) when assessing both cognitive functioning and odor identification. OBJECTIVE: To determine the utility of odor identification as a supplementary screening test in incipient AD. METHODS: Sniffin' Sticks Odor Identification Test (SS-OIT) and the Montreal Cognitive Assessment (MoCA) were administered in 262 AD, 174 MCI [150 amnestic (aMCI), and 24 non-amnestic (naMCI)], and 292 healthy older adults (HOA)...
November 18, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27862003/occurrence-and-concentrations-of-isothiazolinones-in-detergents-and-cosmetics-in-switzerland
#5
Elena Garcia-Hidalgo, Virginie Sottas, Natalie von Goetz, Urs Hauri, Christian Bogdal, Konrad Hungerbühler
BACKGROUND: In recent years, the frequency of contact allergy to isothiazolinones has increased alarmingly in Europe, but only limited data are available on concentrations of isothiazolinones in consumer products. OBJECTIVES: To examine the current frequency of isothiazolinones [methylisothiazolinone (MI), methylchloroisothiazolinone (MCI), benzisothiazolinone (BIT), and octylisothiazolinone (OIT)] in a wide array of detergents and cosmetics relevant for the Swiss population...
November 14, 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27859599/double-blind-placebo-controlled-challenge-showed-that-peanut-oral-immunotherapy-was-effective-for-severe-allergies-without-negative-effects-on-airway-inflammation
#6
Anna Kaarina Kukkonen, Riikka Uotila, Leo Pekka Malmberg, Anna Susanna Pelkonen, Mika Juhani Mäkelä
AIM: This study examined the efficacy and the safety of peanut oral immunotherapy (OIT). METHODS: We recruited 60 patients aged 6-18 years who had a moderate-to-severe reaction to a double-blind placebo-controlled peanut challenge: 39 received OIT during an eight-month build-up phase and maintenance phase and 21 controls avoided peanuts. We measured specific immunoglobulin E and G4 (IgE and IgG4) to peanuts and to Ara h 1, 2, 3, 8, and 9 and monitored adverse events, bronchial hyperresponsiveness (BHR) to methacholine and fractional concentrations of exhaled nitric oxide (FeNO)...
November 12, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27826960/oral-food-desensitization-in-children-with-ige-mediated-cow-s-milk-allergy-immunological-changes-underlying-desensitization
#7
Laura Perezábad, Marta Reche, Teresa Valbuena, Rosina López-Fandiño, Elena Molina, Iván López-Expósito
PURPOSE: This study aimed to evaluate the safety and efficacy to induce clinical desensitization to cow's milk (CM) of an oral immunotherapy (OIT) protocol in a pediatric population with cow's milk allergy (CMA). In addition, the immune responses against β-casein, of peripheral blood mononuclear cells (PBMCs) from CMA patients, before and after the protocol were evaluated and compared to a nonallergic population. METHODS: A group of 20 children with IgE-mediated CMA and 15 nonallergic children were recruited...
January 2017: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/27738689/thermal-oxidative-and-ozone-oxidative-stabilization-effect-of-hybridized-functional-graphene-oxide-in-a-silica-filled-solution-styrene-butadiene-elastomer
#8
Juqiao Su, Zhongguo Zhao, Yajiang Huang, Xia Liao, Qi Yang
Hybridization of modified functional graphene oxide (fGO) in silica-filled solution styrene butadiene rubber (SSBR) endows preferable tensile and dynamic properties before and after thermal oxidative aging, and similar mechanical hysteresis performance compared with the composites without fGO. The preventing mechanism of fGO is attributed to its intrinsic peroxy radical scavenging and gas barrier abilities, which significantly reduces the peroxy radical concentration and oxygen permeability of nanocomposites and then prolongs oxidative induction time (OIT), characterized by differential scanning calorimetry (DSC)...
October 14, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27722345/a-mechanistic-study-of-manganese-iii-acetate-mediated-phosphonyl-group-additions-to-60-and-70-fullerenes-the-oxidative-ion-transfer-mechanism-vs-free-radical-addition
#9
Boris L Tumanskii, Denis S Sabirov, Yury I Lyakhovetsky
The phosphonylation of C60 with HP(O)(OAlk)2 and Mn(OAc)3·2H2O has been considered to occur via a free radical (FR) path involving intermediate radicals ˙P(O)(OAlk)2. The present study provides evidence in support of another mechanism for the reactions, oxidative-ion-transfer (OIT). The mechanism involves the change of an acetate group in Mn(OAc)3 for the phosphonate group and oxidation of C60 by the Mn(OAc)2P(O)(OAlk)2 formed to a pair: (C60˙(+), Mn(OAc)2P(O)(OAlk)2˙(-)) followed by the transfer of the phosphonate anion to give the monophposphonylfullerenyl radical...
September 28, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27628022/the-use-of-omalizumab-in-food-oral-immunotherapy
#10
Roxane Labrosse, François Graham, Anne Des Roches, Philippe Bégin
Food allergy is an important health issue that affects up to 8 % of the population. The management of allergic patients involves allergen avoidance and prompts the treatment of accidental reactions, as no curative treatment is available so far in routine practice. Oral immunotherapy (OIT) is a promising therapeutic alternative, but it is associated with frequent allergic reactions and cost-effectiveness issues. In hopes of reducing such reactions, a number of trials have used omalizumab, an anti-IgE monoclonal humanized antibody, as adjunctive therapy in OIT...
September 14, 2016: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/27609658/omalizumab-facilitates-rapid-oral-desensitization-for-peanut-allergy
#11
Andrew J MacGinnitie, Rima Rachid, Hana Gragg, Sara V Little, Paul Lakin, Antonella Cianferoni, Jennifer Heimall, Melanie Makhija, Rachel Robison, R Sharon Chinthrajah, John Lee, Jennifer Lebovidge, Tina Dominguez, Courtney Rooney, Megan Ott Lewis, Jennifer Koss, Elizabeth Burke-Roberts, Kimberly Chin, Tanya Logvinenko, Jacqueline A Pongracic, Dale T Umetsu, Jonathan Spergel, Kari C Nadeau, Lynda C Schneider
BACKGROUND: Peanut oral immunotherapy is a promising approach to peanut allergy, but reactions are frequent, and some patients cannot be desensitized. The anti-IgE medication omalizumab (Xolair; Genentech, South San Francisco, Calif) might allow more rapid peanut updosing and decrease reactions. OBJECTIVE: We sought to evaluate whether omalizumab facilitated rapid peanut desensitization in highly allergic patients. METHODS: Thirty-seven subjects were randomized to omalizumab (n = 29) or placebo (n = 8)...
September 5, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27609653/novel-baseline-predictors-of-adverse-events-during-oral-immunotherapy-in-children-with-peanut-allergy
#12
Yamini V Virkud, A Wesley Burks, Pamela H Steele, Lloyd J Edwards, Jelena P Berglund, Stacie M Jones, Amy M Scurlock, Tamara T Perry, Robert D Pesek, Brian P Vickery
BACKGROUND: Though peanut oral immunotherapy (OIT) is a promising investigational therapy, its potential is limited by substantial adverse events (AEs), which are relatively understudied. OBJECTIVE: A retrospective analysis was conducted, pooling data from 3 pediatric peanut OIT trials, comprising the largest analysis of peanut OIT safety to date. METHODS: We pooled data from 104 children with peanut allergy from 3 peanut OIT studies. We catalogued AEs from parental reports, daily symptom diaries, and dose escalations...
September 5, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27592279/primary-eosinophilic-gastrointestinal-disorders-in-children-who-have-received-food-oral-immunotherapy
#13
L Á Echeverría-Zudaire, S Fernández-Fernández, A Rayo-Fernández, C Muñóz-Archidona, R Checa-Rodriguez
BACKGROUND: Food oral immunotherapy (OIT) involves the administration of the food allergen causing the symptoms, in order to induce tolerance. Primary eosinophilic gastrointestinal disorders (PEGDs) are characterised by an eosinophil-rich inflammation affecting different locations of the digestive tract. We present a series of patients with PEGDs in a group of children following OIT with milk and/or egg. MATERIAL AND METHODS: A prospective study during the period 2006-2014 was performed in paediatric patients subjected to OIT with milk and/or egg...
November 2016: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/27570533/two-weeks-sustained-unresponsiveness-by-oral-immunotherapy-using-microwave-heated-cow-s-milk-for-children-with-cow-s-milk-allergy
#14
Masaya Takahashi, Shoichiro Taniuchi, Kazuhiko Soejima, Yasuko Hatano, Sohsaku Yamanouchi, Kazuanri Kaneko
BACKGROUND: Several studies have reported that oral immunotherapy (OIT) is effective for children with cow's milk (CM) allergy. These studies reported the efficacy of OIT in terms of desensitization, but did not describe sustained unresponsiveness to CM. The aim of this study was to evaluate the efficacy of the OIT protocol using microwave heated cow's milk (MH-CM) in terms of 2-weeks-sustained unresponsiveness (2-weeks-SU) and safety. METHODS: Forty-eight children were enrolled in this study...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27569751/levels-of-evidence-for-foot-and-ankle-questions-on-the-orthopaedic-in-training-examination-15-year-trends
#15
Cory T Walsh, Louis C Grandizio, Joel C Klena, John M Parenti, Gerard J Cush
BACKGROUND: The foot and ankle (FA) content domain is a component of the orthopaedic in-training examination (OITE). Levels of evidence (LoE) have been infrequently studied on the OITE. The purpose of this study is to determine if LoE for primary journal articles referenced for FA questions increased over a 15-year period. We also aim to determine if reference characteristics and question taxonomy have changed during this period. METHODS: All 132 questions and 261 references in the FA content domain from 1995 to 1997 and from 2010 to 2012 were included...
November 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27543004/recent-advances-in-component-resolved-diagnosis-in-food-allergy
#16
Magnus P Borres, Nobuyuki Maruyama, Sakura Sato, Motohiro Ebisawa
Due to the high prevalence of food allergic diseases globally there are increasing demands in clinical practice for managing IgE-mediated conditions. During the last decade, component resolved diagnostics has been introduced into the field of clinical allergology, providing information that cannot be obtained from extract-based tests. Component resolved data facilitate more precise diagnosis of allergic diseases and identify sensitizations attributable to cross-reactivity. Furthermore it assists risk assessment in clinical practice as sensitization to some allergenic molecules is related to persistence of clinical symptoms and systemic rather than local reactions...
October 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27538353/octylisothiazolinone-an-additional-cause-of-allergic-contact-dermatitis-caused-by-leather-case-series-and-potential-implications-for-the-study-of-cross-reactivity-with-methylisothiazolinone
#17
Olivier Aerts, Hans Meert, Elien Romaen, Julie Leysen, Lucretia Matthieu, Sandra Apers, Julien Lambert, An Goossens
BACKGROUND: Octylisothiazolinone (OIT) is used as an antifungal agent by the leather industry. OBJECTIVES: To show sensitization to OIT from leather, and to highlight the potential implications when cross-reactivity between OIT and methylisothiazolinone (MI) is studied. METHODS: Two patients with allergic contact dermatitis caused by a leather belt and shoes, respectively, were patch tested with methylchloroisothiazolinone (MCI)/MI, MI, MCI, OIT, and benzisothiazolinone (BIT)...
November 2016: Contact Dermatitis
https://www.readbyqxmd.com/read/27537244/changes-in-biomarkers-during-a-six-month-oral-immunotherapy-intervention-for-cow-s-milk-allergy
#18
Susanna Salmivesi, Marita Paassilta, Heini Huhtala, Riina Nieminen, Eeva Moilanen, Matti Korppi
AIM: Oral immunotherapy (OIT) is a promising but still experimental method to treat children with cow's milk (CM) allergy (CMA). We evaluated changes in allergic, immunological and inflammatory parameters, which happened during the six-month OIT for CMA. METHODS: We treated 28 school-aged children with CMA using OIT with a double-blind placebo-controlled design. After the controlled study finished, the placebo group was treated with the same but open-label OIT protocol...
November 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27522159/early-oral-immunotherapy-in-peanut-allergic-preschool-children-is-safe-and-highly-effective
#19
Brian P Vickery, Jelena P Berglund, Caitlin M Burk, Jason P Fine, Edwin H Kim, Jung In Kim, Corinne A Keet, Michael Kulis, Kelly G Orgel, Rishu Guo, Pamela H Steele, Yamini V Virkud, Ping Ye, Benjamin L Wright, Robert A Wood, A Wesley Burks
BACKGROUND: Oral immunotherapy (OIT) is an effective experimental food allergy treatment that is limited by treatment withdrawal and the frequent reversibility of desensitization if interrupted. Newly diagnosed preschool children may have clinical and immunological characteristics more amenable to treatment. OBJECTIVE: We sought to test the safety, effectiveness, and feasibility of early OIT (E-OIT) in the treatment of peanut allergy. METHODS: We enrolled 40 children aged 9 to 36 months with suspected or known peanut allergy...
August 4, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27501424/effects-of-biocide-treatments-on-the-biofilm-community-in-domitilla-s-catacombs-in-rome
#20
Clara Urzì, Filomena De Leo, Lucia Krakova, Domenico Pangallo, Laura Bruno
Different types of biofilms are widespread on lithic faces of the Catacombs of Domitilla (Rome, Italy) due to the favorable microclimatic conditions (temperature, high RH% and low irradiance). The biofilm, once established, becomes particularly dangerous due to the coverage of valuable surfaces causing spoilage, softening of materials and mineral precipitation. It is common practice to treat these surfaces with biocides in order to eradicate the microorganisms present. The aim of the present research was to compare the changes occurring to the microbial community present in the biofilm in one site of the Catacombs of Domitilla (CD15) before and after a biocide treatment (a mixture of quaternary ammonium compounds and octylisothiazolone, OIT), applied for a one month period...
August 5, 2016: Science of the Total Environment
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