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https://www.readbyqxmd.com/read/29729726/looking-into-the-seeds-of-time-are-home-based-oit-programs-the-shape-of-things-to-come-for-selected-patients
#1
EDITORIAL
Matthew Greenhawt, Jonathan O'B Hourihane
No abstract text is available yet for this article.
May 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29707970/orthopaedic-in-training-examination-resources-and-residency-training-for-the-foot-and-ankle-domain
#2
Cory F Janney, Daniel Kunzler, Pejma Shazadeh Safavi, Vinod Panchbhavi
BACKGROUND: Residency programs use the annual Orthopaedic In-Training Examination (OITE) prepared by the American Academy of Orthopaedic Surgeons (AAOS) to monitor resident progress and prepare them for the part 1 of the American Board of Orthopaedic Surgeons (ABOS) Certifying Examination. The purpose of this study was to determine resources residents currently use to prepare for the OITE and also to learn about their perception of training they receive in the foot and ankle subspecialty in their program and their interest in foot and ankle fellowship after residency...
April 1, 2018: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/29700872/oral-immunotherapy-with-omalizumab-reverses-the-th2-cell-like-program-of-regulatory-t-cells-and-restores-their-function
#3
Azza Abdel-Gadir, Lynda Schneider, Arianna Casini, Louis-Marie Charbonnier, Sara V Little, Timothy Harrington, Dale T Umetsu, Rima Rachid, Talal A Chatila
BACKGROUND: Oral immunotherapy (OIT) successfully desensitizes patients with food allergies, but the immune mechanisms mediating its efficacy remain obscure. OBJECTIVES: We tested the hypothesis that allergen-specific regulatory T (Treg) cell function is impaired in food allergy and is restored by anti-IgE antibody (omalizumab)-supplemented OIT. METHODS: Peanut-specific T effector (Teff) and Treg cell proliferative responses, activation markers and cytokine expression were analyzed by flow cytometry in 13 peanut allergic subjects before the start of omalizumab- supplemented OIT and periodically in some subjects thereafter for up to two years...
April 27, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29700869/tree-nut-allergies-allergen-homology-cross-reactivity-and-implications-for-therapy
#4
Johanna M Smeekens, Kenneth Bagley, Michael Kulis
Tree nut allergy is a potentially life-threatening disease that is increasing in prevalence, now affecting 1% of the general population in the United States. While other food allergies often resolve spontaneously, tree nut allergies are outgrown in less than 10% of cases. Due to the likelihood of cross-sensitization to multiple tree nut allergens, the current treatment guideline is strict avoidance of all nuts once one tree nut allergy has been diagnosed. For example, walnut and pecan are highly cross-reactive, along with cashew and pistachio, but the extent of clinical, IgE-mediated cross-reactivity among other tree nuts remains unclear, therefore making avoidance of all tree nuts a safe approach...
April 27, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29698554/long-term-outcome-of-peanut-oral-immunotherapy-real-life-experience
#5
Liat Nachshon, Michael R Goldberg, Yitzhak Katz, Michael B Levy, Arnon Elizur
BACKGROUND: Oral immunotherapy (OIT) is currently recommended as a treatment option for peanut allergic patients. Data regarding its long-term compliance and efficacy in real-life is required. METHODS: Peanut allergic patients aged ≥4 years were enrolled in a single-center clinical OIT program. Build-up to 3000 mg peanut protein was performed. Patients reaching this dose before or after 12/2014 were instructed to consume 3000 mg or 1200 mg daily, respectively...
April 26, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29676066/allergen-specific-immunotherapies-for-food-allergy
#6
REVIEW
Elizabeth Feuille, Anna Nowak-Wegrzyn
With rising prevalence of food allergy (FA), allergen-specific immunotherapy (AIT) for FA has become an active area of research in recent years. In AIT, incrementally increasing doses of inciting allergen are given with the goal to increase tolerance, initially through desensitization, which relies on regular exposure to allergen. With prolonged therapy in some subjects, AIT may induce sustained unresponsiveness, in which tolerance is retained after a period of allergen avoidance. Methods of AIT currently under study in humans include oral, sublingual, epicutaneous, and subcutaneous delivery of modified allergenic protein, as well as via DNA-based vaccines encoding allergen with lysosomal-associated membrane protein I...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29672110/-the-empathy-impulse-a-multinomial-model-of-intentional-and-unintentional-empathy-for-pain-correction
#7
(no author information available yet)
Reports an error in "The empathy impulse: A multinomial model of intentional and unintentional empathy for pain" by C. Daryl Cameron, Victoria L. Spring and Andrew R. Todd ( Emotion , 2017[Apr], Vol 17[3], 395-411). In this article, there was an error in the calculation of some of the effect sizes. The w effect size was manually computed incorrectly. The incorrect number of total observations was used, which affected the final effect size estimates. This computing error does not change any of the results or interpretations about model fit based on the G² statistic, or about significant differences across conditions in process parameters...
April 2018: Emotion
https://www.readbyqxmd.com/read/29656306/oral-and-sublingual-immunotherapy-for-treatment-of-ige-mediated-food-allergy
#8
REVIEW
Amy M Scurlock
Development of active therapies for IgE-mediated food allergy is a critical action step toward alleviating the adverse medical, psychosocial, and economic burdens on affected patients and families. Significant progress has been observed specifically in the application of single-allergen oral and sublingual immunotherapy for treatment of IgE-mediated food allergy, with emphasis on milk, egg, and peanut as the primary allergens. Oral immunotherapy (OIT) has demonstrated efficacy in promoting immunomodulatory effects that lead to the clinical outcome of desensitization, defined as reduced reactivity while on active OIT, in the majority of treated individuals; however, achievement of sustained unresponsiveness following cessation of therapy has been observed in a smaller subset of treated subjects...
April 14, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29608635/older-adult-normative-data-for-the-sniffin-sticks-odor-identification-test
#9
Kayci L Vickers, Kathleen Breslin, David R Roalf, Vidyulata Kamath, Sharon X Xie, Paul J Moberg, David A Wolk, Dawn Mechanic-Hamilton
Objective: The current study establishes normative Sniffin' Sticks Odor Identification Test (SS-OIT) scores for cognitively intact older adults. Method: Two hundred and twenty-six cognitively normal older adults were identified as eligible for the current study (Mean Age = 70.49 years; 71.7% female). Important demographic covariates were identified using step-wise regression, and a normative regression equation was developed. Results: Analyses of the effects of demographic variables (including age, education, and sex) on SS-OIT performance revealed that age was the only significant predictor, b = -0...
March 28, 2018: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/29605677/not-only-biocidal-products-washing-and-cleaning-agents-and-personal-care-products-can-act-as-further-sources-of-biocidal-active-substances-in-wastewater
#10
Stefanie Wieck, Oliver Olsson, Klaus Kümmerer
The emission sources of biocidal active substances in households have been under discussion since these substances have been detected frequently in municipal wastewater and receiving surface water bodies. Therefore, the goal of this study was to investigate the products responsible for the emission of these substances to wastewater. We analysed the wastewater of two streets for a set of biocidal active substances. Time-proportional sampling was conducted for one week of each season during one year in each street...
March 29, 2018: Environment International
https://www.readbyqxmd.com/read/29603410/low-dose-oral-immunotherapy-for-children-with-anaphylactic-peanut-allergy-in-japan
#11
Ken-Ichi Nagakura, Noriyuki Yanagida, Sakura Sato, Makoto Nishino, Tomoyuki Asaumi, Kiyotake Ogura, Motohiro Ebisawa
BACKGROUND: Oral immunotherapy (OIT) is a promising treatment for persons with allergy; however, it can also cause adverse allergic reactions. In this study, we investigated the efficacy of low-dose OIT for anaphylactic peanut allergy. METHODS: Twenty-four children (median age, 9.6 years) with anaphylaxis to peanuts were hospitalized for 5 days and then gradually fed increasing amounts of peanut powder up to 133 mg/day. One year later, they underwent an oral food challenge after 2 weeks of peanut avoidance...
March 30, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29596361/optimal-serum-ferritin-levels-for-iron-deficiency-anemia-during-oral-iron-therapy-oit-in-japanese-hemodialysis-patients-with-minor-inflammation-and-benefit-of-intravenous-iron-therapy-for-oit-nonresponders
#12
Kazuya Takasawa, Chikako Takaeda, Takashi Wada, Norishi Ueda
Background: We determined optimal serum ferritin for oral iron therapy (OIT) in hemodialysis (HD) patients with iron deficiency anemia (IDA)/minor inflammation, and benefit of intravenous iron therapy (IIT) for OIT-nonresponders. Methods: Inclusion criteria were IDA (Hb <120 g/L, serum ferritin <227.4 pmol/L). Exclusion criteria were inflammation (C-reactive protein (CRP) ≥ 5 mg/L), bleeding, or cancer. IIT was withheld >3 months before the study. ΔHb ≥ 20 g/L above baseline or maintaining target Hb (tHB; 120-130 g/L) was considered responsive...
March 29, 2018: Nutrients
https://www.readbyqxmd.com/read/29571889/nationwide-questionnaire-based-survey-of-oral-immunotherapy-in-japan
#13
Sakura Sato, Chizuko Sugizaki, Noriyuki Yanagida, Komei Ito, Yusei Ohshima, Naoki Shimojo, Takao Fujisawa, Motohiro Ebisawa
BACKGROUND: Clinical trials on oral immunotherapy (OIT) have been increasing for nearly a decade; however, several national guidelines do not recommend OIT as a standardized procedure. The aim of this study was to obtain insights into the current use and practice of OIT in Japan. METHODS: A first questionnaire was mailed to 524 training and teaching facilities of the Japan Pediatric Society. The first survey requested information on the implementation of OIT, whereas the second survey aimed to gather more detailed information on OIT, such as its safety...
March 20, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29542268/the-effect-of-oral-immunotherapy-treatment-in-severe-ige-mediated-milk-peanut-and-egg-allergy-in-adults
#14
Jarkko Mäntylä, Tuuli Thomander, Auli Hakulinen, Kaarina Kukkonen, Kati Palosuo, Helena Voutilainen, Anna Pelkonen, Paula Kauppi
INTRODUCTION: The standard care of severe food allergy in both adults and children means avoidance of allergens. In recent years promising results of oral immunotherapy (OIT) have been reported in children. In adults, information on OIT in severe food allergy is very limited. OBJECTIVE: We aimed to study if OIT is possible in adults. METHODS: We report OIT results in 10 adult patients with milk OIT, nine adult patients with peanut OIT, and four adult patients with egg OIT...
March 15, 2018: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29540279/one-child-s-food-fight-a-case-study-of-oral-immunotherapy-treatment-for-food-allergies
#15
Jessica L Peck, E Katherine Larson, Stacy K Silvers
The prevalence of food allergy has risen dramatically in the last two decades. Primary care providers encounter food-allergic children on a daily basis. Although the standard of care has traditionally been strict avoidance of the allergen and advisement to carry an epinephrine autoinjector in case of an accidental exposure resulting in a severe reaction, food allergy research has progressed in the past decade concerning various immunotherapies that may provide an alternate treatment strategy. Oral immunotherapy (OIT), performed under the supervision of an allergist, is the most widely studied of these therapies...
March 12, 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29528585/food-specific-ige-as-a-biomarker-of-oral-immunotherapy-efficacy-in-comparison-to-double-blind-food-challenge-test
#16
Nissreen E ELBadawy, Randa S Abdel-Latif
Specific immunotherapy (SIT) is one of the important lines for the treatment of food allergy. Efficacy tests for clinical response to SIT are limited and subjective. In this study, we aimed to evaluate the validity of food specific Ig E levels as a biomarker of clinical improvement in children with food allergy treated with oral immunotherapy (OIT). We analysed 184 children with food allergy, 143 had undergone 2 years of food OIT and 41 were on allergen restricted diet and considered as control. All patients were subjected to Double-Blind Placebo-Controlled Food Challenge test (DBPCFC), allergic symptom score calculation, and serum food specific Ig E level before and after oral immunotherapy for treated patients and after 2 year of allergen restricted diet for the control group...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29470658/current-status-of-potential-therapies-for-ige-mediated-food-allergy
#17
REVIEW
Christopher P Parrish, Daniel Har, J Andrew Bird
PURPOSE OF REVIEW: The goal of this review is to provide the reader with an updated summary of published trial data regarding the use of oral immunotherapy (OIT), sublingual immunotherapy (SLIT), and epicutaneous immunotherapy (EPIT) for treatment of IgE-mediated food allergies. RECENT FINDINGS: Data from phase 2 trials for treatment of peanut allergy with OIT and EPIT reveal an increase in the threshold of reactivity for peanut-allergic children. Compared to EPIT, OIT promotes a greater increase in the threshold of reactivity; however, adverse events are more common with OIT...
February 22, 2018: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29461206/oral-immunotherapy-with-egg-and-milk-changes-in-peripheral-serum-cytokines-are-not-predictive-factors-for-severe-adverse-reactions-or-for-the-final-report
#18
E García-Lirio, C Gonzalez Diaz, A Gonzalez Hermosa, P Gamboa, R Aranguren, M L Sanz
BACKGROUND: Oral immunotherapy (OIT) is a new approach in patients with food allergy. Various immunological mechanisms underlie the reversal of food allergy. In this paper, we study possible changes in peripheral cytokine patterns during OIT. METHODS: Determinations of cytokines in peripheral blood were made in children who had milk or egg allergy and who received OIT. The determinations were made before and after OIT, and again following a final repeat oral challenge a month after a diet excluding the culprit food...
2018: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29449163/orthopaedic-surgery-residency-rotations-and-correlation-with-orthopaedic-in-training-examination-performance
#19
Aaron I Karlen, Erik J Solberg, Deborah S Quanbeck, Ann E Van Heest
OBJECTIVE: The Orthopaedic In-Training Examination (OITE) is administered annually and is used to assess medical knowledge of orthopedic surgery residents. Beginning in the 2013 to 2014 academic year, the ACGME expanded the postgraduate year (PGY)-1 curriculum from 3 to 6 months of orthopedic surgery rotations. The purpose of this study is to evaluate the effect of increased PGY-1 orthopedic surgery exposure on medical knowledge as measured by the OITE. DESIGN: From 2011 to 2013, 24 PGY-2 residents completed 3 months of PGY-1 orthopedic training (Group 1)...
February 12, 2018: Journal of Surgical Education
https://www.readbyqxmd.com/read/29398331/hand-surgery-questions-on-the-orthopaedic-in-training-examination-analysis-of-content-and-reference
#20
Adam S Martin, M Craig McMains, Andrew G Shacklett, Hisham M Awan
PURPOSE: To provide an updated analysis of the hand surgery section of the Orthopaedic In-Training Examination (OITE) from 2009 to 2015. The goal was to contribute to the existing literature on the analysis of OITE questions, to aid both residents and residency programs in preparation for the OITE and board examination. METHODS: The authors analyzed all OITE questions pertaining to hand surgery between 2009 and 2015. Hand questions were analyzed for category and subcategory of content, cited reference, treatment intervention, and imaging modality used...
February 2, 2018: Journal of Hand Surgery
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