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https://www.readbyqxmd.com/read/28802720/application-of-green-fluorescent-protein-to-measure-antimicrobial-efficacy-and-the-kinetics-of-cell-death-against-escherichia-coli
#1
Richard Greenhalgh, Malcolm Greenhalgh, Fadwa Alshareef, Geoffrey D Robson
Industrial antimicrobials have been extensively used to control unwanted microbial growth by incorporation into a variety of products such as plastics and paints, reducing biodeterioration and biofouling and extending the lifespan of the product. Industrial antimicrobials generally have broad sites of action affecting core cellular functions such as central metabolism, enzyme function, cell wall or DNA synthesis and can either be biocidal or biostatic. In addition, susceptibility can be affected by the metabolic state of the microbe, with metabolically inactive cells generally more resistant than metabolically active cells...
August 9, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28782296/combining-anti-ige-with-oral-immunotherapy
#2
REVIEW
Chunrong Lin, Ivan T Lee, Vanitha Sampath, Chitra Dinakar, Rosemarie H DeKruyff, Lynda C Schneider, Kari C Nadeau
Food allergy is a significant medical problem that affects up to 8% of children in developed countries. At present, there are no curative therapies available in routine practice and management of food allergy involves strict allergen avoidance, education, and prompt treatment upon accidental exposure. Oral immunotherapy (OIT) is an efficacious experimental approach to food allergy and has been shown to provide a substantial benefit in terms of allergen desensitization. However, OIT is associated with high rates of allergic reactions, and the period of protection offered by OIT appears to be limited and highly variable...
August 7, 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28780220/clinical-aspects-of-oral-immunotherapy-for-the-treatment-of-allergies
#3
REVIEW
Noriyuki Yanagida, Sakura Sato, Motohiro Ebisawa
Studies on oral immunotherapy (OIT) have been increasing worldwide. Nevertheless, some concerns exist with this treatment. The rate of long-term sustained unresponsiveness is quite low; moreover, the desensitization or sustained unresponsiveness does not equate to tolerance. Furthermore, adverse reactions are frequent. Therefore, safe and feasible methods for long-term therapies are needed. Novel therapies such as low-dose OIT, hypoallergenic products, and OIT in combination with omalizumab are reported as effective for inducing sustained unresponsiveness and may lead to fewer adverse reactions than standard OIT...
August 2, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28760498/differences-and-similarities-between-sublingual-immunotherapy-of-allergy-and-oral-tolerance
#4
REVIEW
Philippe Moingeon, Laurent Mascarell
Allergen immunotherapy is the only treatment altering the natural course of IgE-mediated allergies. Whereas the subcutaneous route for immunotherapy (SCIT) has been historically considered as a reference, we discuss herein the relative advantages of the sublingual and oral routes as alternatives to SCIT in order to elicit allergen-specific tolerance. The buccal and gut immune systems are similarly organized to favor immune tolerance to antigens/allergens, due to the presence of tolerogenic dendritic cells and macrophages promoting the differentiation of CD4(+) regulatory T cells...
July 28, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28752892/patterns-of-concomitant-allergic-reactions-in-patients-suggest-cross-sensitization-between-octylisothiazolinone-and-methylisothiazolinone
#5
Kristiina Aalto-Korte, Katri Suuronen
BACKGROUND: Recent animal tests have indicated cross-reactivity between methylisothiazolinone (MI), octylisothiazolinone (OIT), and benzisothiazolinone (BIT). OBJECTIVES: To retrospectively analyse concomitant reactions to different isothiazolinones in patients in an occupational dermatology clinic during the ongoing MI contact allergy epidemic. METHODS: We searched patch test files (January 2012 to February 2017) for patients with allergic reactions to OIT, BIT, and MI, and analysed their patch test results, occupations, exposure, and diagnoses...
July 28, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28731411/oral-immunotherapy-for-food-allergy-a-spanish-guideline-immunotherapy-egg-and-milk-spanish-guide-items-guide-part-i-cow-milk-and-egg-oral-immunotherapy-introduction-methodology-rationale-current-state-indications-contraindications-and-oral-immunotherapy-build
#6
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
BACKGROUND AND OBJECTIVE: Cow milk and egg are the most frequent causes of food allergy in the first years of life. Oral immunotherapy (OIT) has been investigated as an alternative to avoidance diets. No clinical practice guidelines on the management of OIT with milk and egg are currently available. Objectives: To develop clinical guidelines for OIT based on available scientific evidence and the opinions of experts. METHODS: A review was made of studies published between 1984 and June 2016, doctoral theses published in Spain, summaries of communications at scientific meetings (SEAIC, SEICAP, EAACI, and AAAAI), and the consensus of opinion established by a group of experts from the scientific societies SEICAP and SEAIC...
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28713525/orthopedic-in-training-examination-question-metrics-and-resident-test-performance
#7
John Mason DePasse, Jack Haglin, Adam E M Eltorai, Mary K Mulcahey, Craig P Eberson, Alan H Daniels
First administered in November 1963, the orthopedic in-training examination (OITE) is now distributed to more than 4000 residents in over 20 countries and has become important for evaluation of resident fund of knowledge. Several studies have assessed the effect of didactic programs on resident performance, but only recently has it become possible to assess detailed testtaking metrics such as time spent per question. Here, we report the first assessment of resident OITE performance utilizing this full electronic dataset from two large academic institutions...
June 23, 2017: Orthopedic Reviews
https://www.readbyqxmd.com/read/28696863/update-on-oral-immunotherapy-for-egg-allergy
#8
François Graham, Natacha Tardio, Louis Paradis, Anne Des Roches, Philippe Bégin
Oral immunotherapy (OIT) is an emerging treatment for IgE-mediated egg allergy. In the past decade, a multitude of studies have assessed the potential for egg OIT to induce clinical desensitization. The following review will evaluate the efficacy and safety of this therapy as determined by randomized controlled, non-randomized controlled and uncontrolled trials. Recent studies using reduced allergenic egg products and anti-IgE assisted therapy to improve egg OIT safety will also be discussed. Recent advances in the mechanisms underlying food OIT suggest that certain immune parameters may be helpful in monitoring response to therapy, including egg OIT...
July 11, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28689791/peanut-specific-tr1-cells-induced-in-vitro-from-allergic-individuals-are-functionally-impaired
#9
Laurence Pellerin, Jennifer Anne Jenks, Sharon Chinthrajah, Tina Dominguez, Whitney Block, Xiaoying Zhou, Arram Noshirvan, Silvia Gregori, Maria Grazia Roncarolo, Kari Christine Nadeau, Rosa Bacchetta
BACKGROUND: Peanut allergy is a life threatening condition which lacks regulatory-approved treatment. T regulatory type 1 (Tr1) cells are potent suppressors of immune responses and can be induced in vivo upon repeated antigen exposure or in vitro using tolerogenic dendritic cells (DC-10). Whether or not oral immunotherapy (OIT) leads to antigen-specific Tr1 cell induction has not been established. OBJECTIVES: To determine whether peanut-specific Tr1 cells can be generated in vitro from peripheral blood of peanut allergic (PA) individuals at baseline or during OIT, and whether they are functional as compared to peanut-specific Tr1 cells induced from healthy controls (HC)...
July 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28685970/invariant-natural-killer-cells-change-after-an-oral-allergy-desensitization-protocol-for-cow-s-milk
#10
Antonella Cianferoni, Rushani Saltzman, Francesca Saretta, Simona Barni, Emily Dudek, Mary Kelleher, Jonathan M Spergel
BACKGROUND: Cow milk (CM) allergy (CMA) affects up to 3% of the pediatric population and recent data suggest that only about 50% will outgrow by age 8. Oral immunotherapy (OIT) is a type of immune-modulating treatment that is able to induce desensitization to food allergens, to increase tolerance threshold, to reduce the risk of anaphylaxis, and to improve the patient's quality of life. The examination of the immunological changes observed during the establishment of food allergy (FA) desensitization in FA patients is a window into the pathogenesis of food allergy and food tolerance development...
July 7, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28676231/oral-immunotherapy-for-food-allergy-a-spanish-guideline-egg-and-milk-immunotherapy-spanish-guide-items-guide-part-2-maintenance-phase-of-cow-milk-cm-and-egg-oral-immunotherapy-oit-special-treatment-dosing-schedules-models-of-dosing-schedules-of-oit-with-cm
#11
REVIEW
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
INTRODUCTION: Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. OBJECTIVES: To develop a clinical guide on OIT based on the available scientific evidence and the opinions of experts. METHODS: A review was made of studies published in the period between 1984 and June 2016, Doctoral Theses published in Spain, and summaries of communications at congresses (SEAIC, SEICAP, EAACI, AAAAI), with evaluation of the opinion consensus established by a group of experts pertaining to the scientific societies SEICAP and SEAIC...
July 1, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28673803/residents-and-program-director-perspectives-often-differ-on-optimal-preparation-strategies-and-the-value-of-the-orthopedic-in-training-examination
#12
Christopher L Camp, Ryan M Degen, Arlen D Hanssen, Joshua S Dines, Matthew D Karam, Norman S Turner
OBJECTIVES: The purpose of this work was to compare resident and program director (PD) perspectives on the value of the Orthopaedic In-Training Examination (OITE), resident study habits, and best resources for optimal performance. DESIGN: A national survey of orthopedic surgery residents and PDs. SETTING: Mayo Clinic, Rochester, MN PARTICIPANTS: The survey was completed by 445 (41.5%) eligible orthopedic surgery residents and 37 (77.1%) PDs...
June 30, 2017: Journal of Surgical Education
https://www.readbyqxmd.com/read/28662773/oral-immunotherapy-for-food-allergy-a-spanish-guideline-immunotherapy-egg-and-milk-spanish-guide-items-guide-part-i-cow-milk-and-egg-oral-immunotherapy-introduction-methodology-rationale-current-state-indications-contraindications-and-oral-immunotherapy-build
#13
REVIEW
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
INTRODUCTION: Cow's milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. OBJECTIVES: To develop a clinical guide on OIT based on the available scientific evidence and the opinions of experts. METHODS: A review was made of studies published in the period between 1984 and June 2016, Doctoral Theses published in Spain, and summaries of communications at congresses (SEAIC, SEICAP, EAACI, AAAAI), with evaluation of the opinion consensus established by a group of experts pertaining to the scientific societies SEICAP and SEAIC...
July 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28653575/evaluation-of-a-new-protocol-for-wheat-desensitization-in-patients-with-wheat-induced-anaphylaxis
#14
Mahsa Rekabi, Saba Arshi, Mohammad Hassan Bemanian, Vahab Rekabi, Abolfazl Rajabi, Morteza Fallahpour, Rasool Molatefi, Sima Shokri, Narges Eslami, Javad Ahmadian, Majid Khoshmirsafa, Farhad Seif, Seyed Alireza Mahdaviani, Nadieh Akbarpour, Mohammad Nabavi
AIM: New approaches such as oral immunotherapy (OIT) may be useful in IgE-mediated anaphylaxis to wheat. PATIENTS & METHODS: 12 patients underwent OIT protocol that comprised of two phases: the first with semolina flour and the second with spaghetti. Total and specific wheat IgE were assayed by ELISA before and after OIT and 18 months later. Skin prick tests were also performed. RESULTS: Patients successfully tolerated 50 g of wheat. The median baseline total IgE was decreased after up-dosing phase and decreased after follow-up (p < 0...
June 2017: Immunotherapy
https://www.readbyqxmd.com/read/28593864/oral-immunotherapy-for-food-allergy-a-spanish-guideline-egg-and-milk-immunotherapy-spanish-guide-items-guide-part-ii
#15
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
BACKGROUND AND OBJECTIVE: Cow´s milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. Objectives: To develop a clinical guide on OIT based on the available scientific evidence and the opinions of experts. METHODS: A review was made of studies published in the period between 1984 and June 2016, Doctoral Theses published in Spain, and summaries of communications at congresses (SEAIC, SEICAP, EAACI, AAAAI), with evaluation of the opinion consensus established by a group of experts pertaining to the scientific societies SEICAP and SEAIC...
June 8, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28593863/oral-immunotherapy-for-food-allergy-a-spanish-guideline-egg-and-milk-immunotherapy-spanish-guide-items-guide-part-i
#16
A Martorell, E Alonso, L Echeverría, C Escudero, R García-Rodríguez, C Blasco, J Bone, J Borja-Segade, T Bracamonte, A Claver, J L Corzo, B De la Hoz, R Del Olmo, O Dominguez, V Fuentes-Aparicio, I Guallar, H Larramona, F Martín-Muñoz, V Matheu, A Michavila, I Ojeda, P Ojeda, M Piquer, P Poza, M Reche, P Rodríguez Del Río, M Rodríguez, F Ruano, S Sánchez-García, S Terrados, L Valdesoiro, M Vazquez-Ortiz
BACKGROUND AND OBJECTIVE: Cow´s milk and egg are the most frequent causes of food allergy in the first years of life. Treatments such as oral immunotherapy (OIT) have been investigated as an alternative to avoidance diets. No clinical practice guides on the management of OIT with milk and egg are currently available. Objectives: To develop a clinical guide on OIT based on the available scientific evidence and the opinions of experts. METHODS: A review was made of studies published in the period between 1984 and June 2016, Doctoral Theses published in Spain, and summaries of communications at congresses (SEAIC, SEICAP, EAACI, AAAAI), with evaluation of the opinion consensus established by a group of experts pertaining to the scientific societies SEICAP and SEAIC...
June 6, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28552874/intake-of-diet-including-1-ovomucoid-for-4-weeks-induces-oral-desensitization-in-ovomucoid-specific-allergic-mouse-model
#17
Akihiro Maeta, Yoko Sakamoto, Sayo Yuki, Kyoko Takahashi
We propose a new oral immunotherapy (OIT) method that includes a small amount of a food allergen in the diet. However, it is not clear whether this method will induce oral desensitization and immune tolerance. Therefore, we investigated the therapeutic effectiveness using a 1% food allergen diet in an allergic mouse model. C3H/HeJ mice were sensitized to ovomucoid (OM) in alum four times at 12-d intervals. Sensitized mice were divided into two groups: the OIT group (19% casein diet with 1% OM) and the non-treated group (20% casein diet without OM)...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28549059/elimination-diet-and-the-development-of-multiple-tree-nut-allergies
#18
Arnon Elizur, Jennifer B Bollyky, Whitney M Block
BACKGROUNDDespite its high prevalence, relatively little is known about the characteristics of patients with multiple tree-nuts allergies.METHODSPatients (n=60, aged 4-15 years), recruited for a multiple food (tree-nuts, peanut, milk, egg, soy, sesame and wheat) oral immunotherapy (OIT) study, filled a questionnaire on their initial allergy evaluation. Medical records were reviewed. At OIT enrollment (median interval, 7.5 years), patients underwent oral food challenges (OFC) to foods still eliminated.RESULTSThere was significantly less evidence for eliminating tree-nuts compared to other foods, as reflected by lower rate of acute reaction to the offending food, either as the trigger for initial allergy evaluation (5...
May 26, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28542911/changes-in-patient-quality-of-life-during-oral-immunotherapy-for-food-allergy
#19
N Epstein Rigbi, M R Goldberg, M B Levy, L Nachshon, K Golobov, A Elizur
BACKGROUND: Quality of life (QOL) is impaired in patients with food allergy and improves following oral immunotherapy (OIT). However, the treatment itself is prolonged and demanding. We examined changes in patient QOL during OIT for food allergy. METHODS: The FAQLQ-PF was administered to children aged 4-12 years undergoing OIT for milk, peanut, or egg allergy, at the beginning and after 4 months of treatment. Patients were categorized as improved, unchanged, or diminished FAQLQ-PF (>0...
May 22, 2017: Allergy
https://www.readbyqxmd.com/read/28479335/allergen-specific-igg-antibodies-signaling-via-fc%C3%AE-riib-promote-food-tolerance
#20
Oliver T Burton, Jaciel M Tamayo, Amanda J Stranks, Kyle J Koleoglou, Hans C Oettgen
BACKGROUND: Food-allergic subjects produce high-titer IgE antibodies that bind to mast cells via FcεRI and trigger immediate hypersensitivity reactions upon antigen encounter. Food-specific IgG antibodies arise in the setting of naturally resolving food allergy and accompany the acquisition of food allergen unresponsiveness in oral immunotherapy (OIT). OBJECTIVE: In this study, we sought to delineate the effects of IgG and its inhibitory Fc receptor, FcγRIIb, on both de novo allergen sensitization in naïve animals and on established immune responses in the setting of pre-existing food allergy...
May 4, 2017: Journal of Allergy and Clinical Immunology
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