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Cláudia Carvalho, Joaquim Machado Caetano, Lidia Cunha, Paula Rebouta, Ted J Kaptchuk, Irving Kirsch
This randomized controlled trial was performed to investigate whether placebo effects in chronic low back pain could be harnessed ethically by adding open-label placebo (OLP) treatment to treatment as usual (TAU) for 3 weeks. Pain severity was assessed on three 0- to 10-point Numeric Rating Scales, scoring maximum pain, minimum pain, and usual pain, and a composite, primary outcome, total pain score. Our other primary outcome was back-related dysfunction, assessed on the Roland-Morris Disability Questionnaire...
October 13, 2016: Pain
A Rosén, J Yi, I Kirsch, T J Kaptchuk, M Ingvar, K B Jensen
BACKGROUND: Expectancy is widely accepted as a key contributor to placebo effects. However, it is not known whether non-conscious expectancies achieved through semantic priming may contribute to placebo analgesia. In this study, we investigated if an implicit priming procedure, where participants were unaware of the intended priming influence, affected placebo analgesia. METHODS: In a double-blind experiment, healthy participants (n = 36) were randomized to different implicit priming types; one aimed at increasing positive expectations and one neutral control condition...
October 17, 2016: European Journal of Pain: EJP
K T Hall, J Kossowsky, T F Oberlander, T J Kaptchuk, J P Saul, V B Wyller, E Fagermoen, D Sulheim, J Gjerstad, A Winger, K J Mukamal
Clonidine, an α2-adrenergic receptor agonist, decreases circulating norepinephrine and epinephrine, attenuating sympathetic activity. Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment are unknown. Chronic fatigue syndrome (CFS) is hypothesized to result in part from dysregulated sympathetic function. A candidate gene analysis of COMT rs4680 effects on clinical outcomes in the Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial (NorCAPITAL), a randomized double-blinded clonidine versus placebo trial, was conducted (N=104)...
October 2016: Pharmacogenomics Journal
Jing-Si Zhang, Yi-Zheng Wang, Ya-Qiong Hu, Fan Lin, Dong Gao, Jun Song, Ted J Kaptchuk, Ke-Ji Chen
OBJECTIVE: To evaluate the effect of Xuefu Zhuyu Capsule ()-containing serum (XFZY-CS) on EphB4/ephrinB2 and its reverse signal in human microvascular endothelial cell-1 (HMEC-1). METHODS: XFZY-CS and the blank control serum were collected. HMEC-1 cells were randomly assigned to 6 groups including the concentration 1.25%, 2.5%, and 5% XFZY-CS groups and their blank serum control ones. The angiogenesis effect of XFZY-CS was tested with an in vitro tube formation assay and the best condition of pro-angiogenesis was determined...
August 2016: Chinese Journal of Integrative Medicine
Kathryn T Hall, Kathleen A Jablonski, Ling Chen, Maegan Harden, Benjamin R Tolkin, Ted J Kaptchuk, George A Bray, Paul M Ridker, Jose C Florez, Kenneth J Mukamal, Daniel I Chasman
AIMS: Catecholamines have metabolic effects on blood pressure, insulin sensitivity and blood glucose. Genetic variation in catechol-O-methyltransferase (COMT), an enzyme that degrades catecholamines, is associated with cardiometabolic risk factors and incident cardiovascular disease (CVD). Here we examined COMT effects on glycemic function and type 2 diabetes. METHODS: We tested whether COMT polymorphisms were associated with baseline HbA1c in the Women's Genome Health Study (WGHS), and Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), and with susceptibility to type 2 diabetes in WGHS, DIAbetes Genetics Replication And Meta-analysis consortium (DIAGRAM), and the Diabetes Prevention Program (DPP)...
July 2016: Metabolism: Clinical and Experimental
Kevin R Fontaine, Michelle S Williams, Teri W Hoenemeyer, Ted J Kaptchuk, Gareth R Dutton
No abstract text is available yet for this article.
April 2016: Obesity
David M Eisenberg, Ted J Kaptchuk, Diana E Post, Andrea L Hrbek, Bonnie B O'Connor, Kamila Osypiuk, Peter M Wayne, Julie E Buring, Donald B Levy
Integrative medicine (IM) refers to the combination of conventional and "complementary" medical services (e.g., chiropractic, acupuncture, massage, mindfulness training). More than half of all medical schools in the United States and Canada have programs in IM, and more than 30 academic health centers currently deliver multidisciplinary IM care. What remains unclear, however, is the ideal delivery model (or models) whereby individuals can responsibly access IM care safely, effectively, and reproducibly in a coordinated and cost-effective way...
September 2016: Academic Medicine: Journal of the Association of American Medical Colleges
Michelle L Dossett, Roger B Davis, Ted J Kaptchuk, Gloria Y Yeh
We used the 2012 National Health Interview Survey to compare homeopathy users with supplement users and those using other forms of complementary and integrative medicine. Among US adults, 2.1% used homeopathy within the past 12 months. Respiratory and otorhinolaryngology complaints were most commonly treated (18.5%). Homeopathy users were more likely to use multiple complementary and integrative medicine therapies and to perceive the therapy as helpful than were supplement users. US homeopathy use remains uncommon; however, users perceive it as helpful...
April 2016: American Journal of Public Health
Charlotte Blease, Luana Colloca, Ted J Kaptchuk
The doctor-patient relationship is built on an implicit covenant of trust, yet it was not until the post-World War Two era that respect for patient autonomy emerged as an article of mainstream medical ethics. Unlike their medical forebears, physicians today are expected to furnish patients with adequate information about diagnoses, prognoses and treatments. Against these dicta there has been ongoing debate over whether placebos pose a threat to patient autonomy. A key premise underlying medical ethics discussion is the notion that the placebo effect necessitates patient deception...
July 2016: Bioethics
Wayne B Jonas, Cindy Crawford, Luana Colloca, Ted J Kaptchuk, Bruce Moseley, Franklin G Miller, Levente Kriston, Klaus Linde, Karin Meissner
OBJECTIVES: To assess the quantity and quality of randomised, sham-controlled studies of surgery and invasive procedures and estimate the treatment-specific and non-specific effects of those procedures. DESIGN: Systematic review and meta-analysis. DATA SOURCES: We searched PubMed, EMBASE, CINAHL, CENTRAL (Cochrane Library), PILOTS, PsycInfo, DoD Biomedical Research,, NLM catalog and NIH Grantee Publications Database from their inception through January 2015...
2015: BMJ Open
Sagar Vijapura, Johannes A C Laferton, David Mintz, Ted J Kaptchuk, David Wolfe
OBJECTIVE: Recent meta-analyses of antidepressant clinical trials have suggested that up to 82 % of response can be attributed to non-medication-related factors. The present study examines psychiatrists' attitudes regarding non-pharmacologic factors within the context of antidepressant pharmacotherapy. METHODS: A web-based, 20-question cross-sectional survey was distributed to 101 staff psychiatrists and 48 post-graduate trainees in psychiatry at an academic hospital in Boston, MA...
October 2016: Academic Psychiatry
Long T Nguyen, Ted J Kaptchuk, Roger B Davis, Giac Nguyen, Van Pham, Stephen M Tringale, Yen Lin Loh, Paula Gardiner
OBJECTIVES: Little is known about Traditional Vietnamese Medicine (TVM) and its use among Vietnamese immigrants in the United States. This study aimed to characterize TVM and improve understanding of its use among Vietnamese outpatients attending an urban clinic. METHODS: This cross-sectional observation study was performed by mailing bilingual surveys to a stratified random sample of 400 Vietnamese adult patients (≥18 years of age) who had visited a community health center in Boston, Massachusetts, at least once in the prior 12 months...
February 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Michelle L Dossett, Lin Mu, Roger B Davis, Iris R Bell, Anthony J Lembo, Ted J Kaptchuk, Gloria Y Yeh
BACKGROUND: It is unclear whether the benefits that some patients derive from complementary and integrative medicine (CIM) are related to the therapies recommended or to the consultation process as some CIM provider visits are more involved than conventional medical visits. Many patients with gastrointestinal conditions seek out CIM therapies, and prior work has demonstrated that the quality of the patient-provider interaction can improve health outcomes in irritable bowel syndrome, however, the impact of this interaction on gastroesophageal reflux disease (GERD) is unknown...
2015: PloS One
V Napadow, A Li, M L Loggia, J Kim, I Mawla, G Desbordes, P C Schalock, E A Lerner, T N Tran, J Ring, B R Rosen, T J Kaptchuk, F Pfab
BACKGROUND: Psychological factors are known to significantly modulate itch in patients suffering from chronic itch. Itch is also highly susceptible to both placebo and nocebo (negative placebo) effects. Brain activity likely supports nocebo-induced itch, but is currently unknown. METHODS: We collected functional MRI (fMRI) data from atopic dermatitis (AD) patients, in a within-subject design, and contrast brain response to nocebo saline understood to be allergen vs open-label saline control...
November 2015: Allergy
Fan Lin, Bin-Ling Chen, Yi-Zheng Wang, Dong Gao, Jun Song, T J Kaptchuk, Ke-Ji Chen
OBJECTIVE: To compare the angiogenesis behaviors of vascular endothelial growth factor (VEGF) and Chinese medicine Xuefu Zhuyu Decoction (, XZD) treatments. METHODS: Human microvascular endothelial cells (HMEC-1) were treated with various concentrations of either XZD-containing serum (XZD-CS) or VEGF for 24, 48, and 72 h, respectively. Cell viability, proliferation, migration, adhesion, and in vitro tube formation assays were used to assess their angiogenic effects...
August 14, 2015: Chinese Journal of Integrative Medicine
Paula Gardiner, Amanda C Filippelli, Karim Kabbara, Steven C Lin, Ekaterina Sadikova, Ted J Kaptchuk, Kathi Kemper
BACKGROUND: Little is known about the feasibility of online education in improving communication and documentation of dietary supplements (DS) among clinicians. METHODS: This prospective educational study included clinicians at an urban teaching hospital. The curriculum included video streams, didactics, and interactive case presentations to discuss (1) DS safety and effectiveness, (2) cultural competency, (3) managing DS in a hospital setting, and (4) DS adverse events...
October 2015: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
Aurore Curie, Kathy Yang, Irving Kirsch, Randy L Gollub, Vincent des Portes, Ted J Kaptchuk, Karin B Jensen
BACKGROUND: Genetically determined Intellectual Disability (ID) is an intractable condition that involves severe impairment of mental abilities such as learning, reasoning and predicting the future. As of today, little is known about the placebo response in patients with ID. OBJECTIVE: To determine if placebo response exists in patients with genetically determined ID. DATA SOURCES AND STUDY SELECTION: We searched Medline/PubMed, EMBASE, CENTRAL and PsycINFO to find all placebo-controlled double-blind randomized clinical trials (RCTs) in patients with genetically determined ID, published up to April 2013, focusing on core ID symptoms...
2015: PloS One
Ted J Kaptchuk, Franklin G Miller
Placebo effects are often considered the effects of an "inert substance," but that characterization is misleading. In a broad sense, placebo effects are improvements in patients' symptoms that are attributable to their participation in the therapeutic encounter, with its rituals, symbols, and..
July 2, 2015: New England Journal of Medicine
Paula Gardiner, Ekaterina Sadikova, Amanda C Filippelli, Suzanne Mitchell, Laura F White, Robert Saper, Ted J Kaptchuk, Brian W Jack, Lisa Fredman
OBJECTIVE: Little is known about the use of Stress Management and Relaxation Techniques (SMART) in racially diverse inpatients. We hope to identify socioeconomic status (SES) factors, health behavior factors, and clinical factors associated with the use of SMART. DESIGN AND MAIN OUTCOME MEASURES: We conducted a secondary analysis of baseline data from 623 hospitalized patients enrolled in the Re-Engineered Discharge (RED) clinical trial. We assessed socio-demographic characteristics and use of SMART...
June 2015: Complementary Therapies in Medicine
Karin Jensen, Irving Kirsch, Sara Odmalm, Ted J Kaptchuk, Martin Ingvar
Pain reduction and enhancement can be produced by means of conditioning procedures, yet the role of awareness during the acquisition stage of classical conditioning is unknown. We used psychophysical measures to establish whether conditioned analgesic and hyperalgesic responses could be acquired by unseen (subliminally presented) stimuli. A 2 × 2 factorial design, including subliminal/supraliminal exposures of conditioning stimuli (CS) during acquisition/extinction, was used. Results showed significant analgesic and hyperalgesic responses (P < 0...
June 23, 2015: Proceedings of the National Academy of Sciences of the United States of America
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