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https://www.readbyqxmd.com/read/28709452/influence-of-the-patient-practitioner-interaction-context-on-acupuncture-outcomes-in-functional-dyspepsia-study-protocol-for-a-multicenter-randomized-controlled-trial
#1
Seok-Jae Ko, Jae-Woo Park, Jungtae Leem, Ted J Kaptchuk, Vitaly Napadow, Braden Kuo, Jessica Gerber, Laurie Dimisko, Inkwon Yeo, Junhee Lee, Jinsung Kim
BACKGROUND: In the treatment of functional dyspepsia, the placebo effect has been reported to be high, and the influence of the patient-practitioner relationship may be a major component of this effect. The specific and non-specific effects of acupuncture cannot be easily distinguished, and the patient-practitioner relationship may influence the total therapeutic effect in clinical practice. There have been no studies that investigate the influence of patient-practitioner relationship on acupuncture treatment for patients with functional dyspepsia...
July 14, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28570268/network-analysis-of-the-genomic-basis-of-the-placebo-effect
#2
Rui-Sheng Wang, Kathryn T Hall, Franco Giulianini, Dani Passow, Ted J Kaptchuk, Joseph Loscalzo
The placebo effect is a phenomenon in which patients who are given an inactive treatment (e.g., inert pill) show a perceived or actual improvement in a medical condition. Placebo effects in clinical trials have been investigated for many years especially because placebo treatments often serve as the control arm of randomized clinical trial designs. Recent observations suggest that placebo effects may be modified by genetics. This observation has given rise to the term "placebome," which refers to a group of genome-related mediators that affect an individual's response to placebo treatments...
June 2, 2017: JCI Insight
https://www.readbyqxmd.com/read/28545508/open-label-versus-double-blind-placebo-treatment-in-irritable-bowel-syndrome-study-protocol-for-a-randomized-controlled-trial
#3
Sarah Ballou, Ted J Kaptchuk, William Hirsch, Judy Nee, Johanna Iturrino, Kathryn T Hall, John M Kelley, Vivian Cheng, Irving Kirsch, Eric Jacobson, Lisa Conboy, Anthony Lembo, Roger B Davis
BACKGROUND: Placebo medications, by definition, are composed of inactive ingredients that have no physiological effect on symptoms. Nonetheless, administration of placebo in randomized controlled trials (RCTs) and in clinical settings has been demonstrated to have significant impact on many physical and psychological complaints. Until recently, conventional wisdom has suggested that patients must believe that placebo pills actually contain (or, at least, might possibly contain) active medication in order to elicit a response to placebo...
May 25, 2017: Trials
https://www.readbyqxmd.com/read/28537834/when-respecting-autonomy-is-harmful-a-clinically-useful-approach-to-the-nocebo-effect
#4
John T Fortunato, Jason Adam Wasserman, Daniel Londyn Menkes
Nocebo effects occur when an adverse effect on the patient arises from the patient's own negative expectations. In accordance with informed consent, providers often disclose information that results in unintended adverse outcomes for the patient. While this may adhere to the principle of autonomy, it violates the doctrine of "primum non nocere," given that side-effect disclosure may cause those side effects. In this article we build off previous work, particularly by Wells and Kaptchuk ( 2012 ) and by Cohen ( 2013 ), to suggest ethical guidelines that permit nondisclosure in the case when a nocebo effect is likely to occur on of the basis of nonmaleficence...
June 2017: American Journal of Bioethics: AJOB
https://www.readbyqxmd.com/read/28424273/certainty-of-genuine-treatment-increases-drug-responses-among-intellectually-disabled-patients
#5
Karin B Jensen, Irving Kirsch, Moa Pontén, Annelie Rosén, Kathy Yang, Randy L Gollub, Vincent des Portes, Ted J Kaptchuk, Aurore Curie
OBJECTIVE: To determine the placebo component of treatment responses in patients with intellectual disability (ID). METHODS: A statistical meta-analysis comparing bias-corrected effect sizes (Hedges g) of drug responses in open-label vs placebo-controlled clinical trials was performed, as these trial types represent different certainty of receiving genuine treatment (100% vs 50%). Studies in fragile X, Down, Prader-Willi, and Williams syndrome published before June 2015 were considered...
May 16, 2017: Neurology
https://www.readbyqxmd.com/read/28334999/rewiring-the-primary-somatosensory-cortex-in-carpal-tunnel-syndrome-with-acupuncture
#6
RANDOMIZED CONTROLLED TRIAL
Yumi Maeda, Hyungjun Kim, Norman Kettner, Jieun Kim, Stephen Cina, Cristina Malatesta, Jessica Gerber, Claire McManus, Rebecca Ong-Sutherland, Pia Mezzacappa, Alexandra Libby, Ishtiaq Mawla, Leslie R Morse, Ted J Kaptchuk, Joseph Audette, Vitaly Napadow
Carpal tunnel syndrome is the most common entrapment neuropathy, affecting the median nerve at the wrist. Acupuncture is a minimally-invasive and conservative therapeutic option, and while rooted in a complex practice ritual, acupuncture overlaps significantly with many conventional peripherally-focused neuromodulatory therapies. However, the neurophysiological mechanisms by which acupuncture impacts accepted subjective/psychological and objective/physiological outcomes are not well understood. Eligible patients (n = 80, 65 female, age: 49...
April 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28187105/reply
#7
LETTER
Claudia Carvalho, Irving Kirsch, Ted J Kaptchuk
No abstract text is available yet for this article.
March 2017: Pain
https://www.readbyqxmd.com/read/28178072/side-effects-can-enhance-treatment-response-through-expectancy-effects-an-experimental-analgesic-randomized-controlled-trial
#8
Chantal Berna, Irving Kirsch, Sean R Zion, Yvonne C Lee, Karin B Jensen, Pamela Sadler, Ted J Kaptchuk, Robert R Edwards
In randomized controlled trials, medication side effects may lead to beliefs that one is receiving the active intervention and enhance active treatment responses, thereby increasing drug-placebo differences. We tested these hypotheses with an experimental double-blind randomized controlled trial of a nonsteroidal anti-inflammatory drug with and without the addition of atropine to induce side effects. One hundred healthy volunteers were told they would be randomized to either combined analgesics that might produce dry mouth or inert placebos...
June 2017: Pain
https://www.readbyqxmd.com/read/28162572/-336-investigating-the-neural-circuitry-supporting-clinical-pain-perception-in-chronic-low-back-pain-the-importance-of-cardiorespiratory-artifact-correction-with-arterial-spin-labeling-fmri
#9
I Mawla, M Loggia, V Schmithorst, A Ortiz, J Gerber, E Protsenko, J Lee, J Kim, H Kim, C Berna, T Kaptchuk, J Kong, R Gollub, B Rosen, R Edwards, A Wasan, V Napadow
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28159769/informed-consent-and-clinical-trials-where-is-the-placebo-effect
#10
C R Blease, F L Bishop, T J Kaptchuk
No abstract text is available yet for this article.
February 3, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27863847/parental-attitudes-about-placebo-use-in-children
#11
Vanda Faria, Joe Kossowsky, Mike P Petkov, Ted J Kaptchuk, Irving Kirsch, Alyssa Lebel, David Borsook
OBJECTIVE: To assess parental attitudes regarding placebo use in pediatric randomized controlled trials and clinical care. STUDY DESIGN: Parents with children under age 18 years living in the US completed and submitted an online survey between September and November 2014. RESULTS: Among all 1300 participants, 1000 (76.9%; 538 mothers and 462 fathers) met the study inclusion criteria. The majority of surveyed parents considered the use of placebos acceptable in some pediatric care situations (86%) and some pediatric trials (91...
February 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/27755279/open-label-placebo-treatment-in-chronic-low-back-pain-a-randomized-controlled-trial
#12
Cláudia Carvalho, Joaquim Machado Caetano, Lidia Cunha, Paula Rebouta, Ted J Kaptchuk, Irving Kirsch
This randomized controlled trial was performed to investigate whether placebo effects in chronic low back pain could be harnessed ethically by adding open-label placebo (OLP) treatment to treatment as usual (TAU) for 3 weeks. Pain severity was assessed on three 0- to 10-point Numeric Rating Scales, scoring maximum pain, minimum pain, and usual pain, and a composite, primary outcome, total pain score. Our other primary outcome was back-related dysfunction, assessed on the Roland-Morris Disability Questionnaire...
December 2016: Pain
https://www.readbyqxmd.com/read/27748563/effects-of-subtle-cognitive-manipulations-on-placebo-analgesia-an-implicit-priming-study
#13
A Rosén, J Yi, I Kirsch, T J Kaptchuk, M Ingvar, K B Jensen
BACKGROUND: Expectancy is widely accepted as a key contributor to placebo effects. However, it is not known whether non-conscious expectancies achieved through semantic priming may contribute to placebo analgesia. In this study, we investigated if an implicit priming procedure, where participants were unaware of the intended priming influence, affected placebo analgesia. METHODS: In a double-blind experiment, healthy participants (n = 36) were randomized to different implicit priming types; one aimed at increasing positive expectations and one neutral control condition...
April 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/27457818/genetic-variation-in-catechol-o-methyltransferase-modifies-effects-of-clonidine-treatment-in-chronic-fatigue-syndrome
#14
RANDOMIZED CONTROLLED TRIAL
K T Hall, J Kossowsky, T F Oberlander, T J Kaptchuk, J P Saul, V B Wyller, E Fagermoen, D Sulheim, J Gjerstad, A Winger, K J Mukamal
Clonidine, an α2-adrenergic receptor agonist, decreases circulating norepinephrine and epinephrine, attenuating sympathetic activity. Although catechol-O-methyltransferase (COMT) metabolizes catecholamines, main effectors of sympathetic function, COMT genetic variation effects on clonidine treatment are unknown. Chronic fatigue syndrome (CFS) is hypothesized to result in part from dysregulated sympathetic function. A candidate gene analysis of COMT rs4680 effects on clinical outcomes in the Norwegian Study of Chronic Fatigue Syndrome in Adolescents: Pathophysiology and Intervention Trial (NorCAPITAL), a randomized double-blinded clonidine versus placebo trial, was conducted (N=104)...
October 2016: Pharmacogenomics Journal
https://www.readbyqxmd.com/read/27299459/effect-of-ephb4-ephrinb2-reverse-signal-on-angiogenesis-induced-by-xuefu-zhuyu-capsule-containing-serum-in-human-microvascular-endothelial-cell-1
#15
RANDOMIZED CONTROLLED TRIAL
Jing-Si Zhang, Yi-Zheng Wang, Ya-Qiong Hu, Fan Lin, Dong Gao, Jun Song, Ted J Kaptchuk, Ke-Ji Chen
OBJECTIVE: To evaluate the effect of Xuefu Zhuyu Capsule ()-containing serum (XFZY-CS) on EphB4/ephrinB2 and its reverse signal in human microvascular endothelial cell-1 (HMEC-1). METHODS: XFZY-CS and the blank control serum were collected. HMEC-1 cells were randomly assigned to 6 groups including the concentration 1.25%, 2.5%, and 5% XFZY-CS groups and their blank serum control ones. The angiogenesis effect of XFZY-CS was tested with an in vitro tube formation assay and the best condition of pro-angiogenesis was determined...
August 2016: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27282867/catechol-o-methyltransferase-association-with-hemoglobin-a1c
#16
Kathryn T Hall, Kathleen A Jablonski, Ling Chen, Maegan Harden, Benjamin R Tolkin, Ted J Kaptchuk, George A Bray, Paul M Ridker, Jose C Florez, Kenneth J Mukamal, Daniel I Chasman
AIMS: Catecholamines have metabolic effects on blood pressure, insulin sensitivity and blood glucose. Genetic variation in catechol-O-methyltransferase (COMT), an enzyme that degrades catecholamines, is associated with cardiometabolic risk factors and incident cardiovascular disease (CVD). Here we examined COMT effects on glycemic function and type 2 diabetes. METHODS: We tested whether COMT polymorphisms were associated with baseline HbA1c in the Women's Genome Health Study (WGHS), and Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC), and with susceptibility to type 2 diabetes in WGHS, DIAbetes Genetics Replication And Meta-analysis consortium (DIAGRAM), and the Diabetes Prevention Program (DPP)...
July 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27028278/placebo-effects-in-obesity-research
#17
EDITORIAL
Kevin R Fontaine, Michelle S Williams, Teri W Hoenemeyer, Ted J Kaptchuk, Gareth R Dutton
No abstract text is available yet for this article.
April 2016: Obesity
https://www.readbyqxmd.com/read/27028029/establishing-an-integrative-medicine-program-within-an-academic-health-center-essential-considerations
#18
David M Eisenberg, Ted J Kaptchuk, Diana E Post, Andrea L Hrbek, Bonnie B O'Connor, Kamila Osypiuk, Peter M Wayne, Julie E Buring, Donald B Levy
Integrative medicine (IM) refers to the combination of conventional and "complementary" medical services (e.g., chiropractic, acupuncture, massage, mindfulness training). More than half of all medical schools in the United States and Canada have programs in IM, and more than 30 academic health centers currently deliver multidisciplinary IM care. What remains unclear, however, is the ideal delivery model (or models) whereby individuals can responsibly access IM care safely, effectively, and reproducibly in a coordinated and cost-effective way...
September 2016: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/26890179/homeopathy-use-by-us-adults-results-of-a-national-survey
#19
Michelle L Dossett, Roger B Davis, Ted J Kaptchuk, Gloria Y Yeh
We used the 2012 National Health Interview Survey to compare homeopathy users with supplement users and those using other forms of complementary and integrative medicine. Among US adults, 2.1% used homeopathy within the past 12 months. Respiratory and otorhinolaryngology complaints were most commonly treated (18.5%). Homeopathy users were more likely to use multiple complementary and integrative medicine therapies and to perceive the therapy as helpful than were supplement users. US homeopathy use remains uncommon; however, users perceive it as helpful...
April 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/26840547/are-open-label-placebos-ethical-informed-consent-and-ethical-equivocations
#20
Charlotte Blease, Luana Colloca, Ted J Kaptchuk
The doctor-patient relationship is built on an implicit covenant of trust, yet it was not until the post-World War Two era that respect for patient autonomy emerged as an article of mainstream medical ethics. Unlike their medical forebears, physicians today are expected to furnish patients with adequate information about diagnoses, prognoses and treatments. Against these dicta there has been ongoing debate over whether placebos pose a threat to patient autonomy. A key premise underlying medical ethics discussion is the notion that the placebo effect necessitates patient deception...
July 2016: Bioethics
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