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Immunostimulating compound

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https://www.readbyqxmd.com/read/29118332/poly-%C3%AE-hydroxybutyrate-administration-during-early-life-effects-on-performance-immunity-and-microbial-community-of-european-sea-bass-yolk-sac-larvae
#1
Andrea Franke, Olivia Roth, Peter De Schryver, Till Bayer, Linsey Garcia-Gonzalez, Sven Künzel, Peter Bossier, Joanna J Miest, Catriona Clemmesen
The reliable production of marine fish larvae is one of the major bottlenecks in aquaculture due to high mortalities mainly caused by infectious diseases. To evaluate if the compound poly-β-hydroxybutyrate (PHB) might be a suitable immunoprophylactic measure in fish larviculture, its capacity to improve immunity and performance in European sea bass (Dicentrarchus labrax) yolk-sac larvae was explored. PHB was applied from mouth opening onwards to stimulate the developing larval immune system at the earliest possible point in time...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28968926/immunopotentiating-significance-of-conventionally-used-plant-adaptogens-as-modulators-in-biochemical-and-molecular-signalling-pathways-in-cell-mediated-processes
#2
REVIEW
Pardeep Kaur, Robin, Victor O Makanjuola, Rohit Arora, Balbir Singh, Saroj Arora
Natural products are of great surge in the identification of chemopreventive agents and biologically active molecules for the development of new promising therapeutic agents. These agents influence the cascade of biochemical and molecular signalling pathways involved in numerous physiological and pathological processes. The natural agents combat the dogma associated with the most dreaded, unconquered health concern and a multigenic disease- cancer. A category of plants known as adaptogens maintain perturbed homoeostasis, augment adaptations to noxious stimuli (exposure to cold, heat, pain, general stress, infectious organisms) and offer endurance to attenuate several disorders in human beings...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28863888/marine-yeast-yarrowia-lipolytica-improves-the-immune-responses-in-pacific-red-snapper-lutjanus-peru-leukocytes
#3
Erika Alamillo, Martha Reyes-Becerril, Alberto Cuesta, Carlos Angulo
The climatic conditions in saltern saline environments allows the growth of microorganisms adapted to these peculiar ambient and could represent a promising source of new bioactive compounds that could have applications on as animal food supplements, including aquaculture. In this study, we evaluated the role of Yarrowia lipolytica N-6 isolate, from a hypersaline natural environment (Guerrero Negro, Baja California Sur, Mexico), as immunostimulant of the non-specific immune response of head-kidney and spleen Pacific red snapper (Lutjanus peru) leukocytes after challenge with Vibrio parahaemolyticus...
August 30, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28826286/characterization-and-evaluation-of-stabilized-particulate-formulations-as-therapeutic-oral-vaccines-for-allergy
#4
Kan Kaneko, Arlene McDowell, Yasuyuki Ishii, Sarah Hook
Allergic conditions affect more than a quarter of the population in developed countries, but currently available treatments focus more on symptom relief than treating the underlying atopic condition. α-galactosylceramide (α-GalCer) is a potent immunomodulating compound that has been shown to have a regulatory effect when delivered systemically in nanoparticles. Parenteral delivery is not preferred for chronic conditions such as allergy, therefore the aim of this study was to determine if a regulatory response could be induced through oral administration in a model of atopy through incorporation of α-GalCer into stable particulate formulations (cationic liposomes, polymerized liposomes and poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs))...
August 21, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28808657/nanoparticulate-tubular-immunostimulating-complexes-novel-formulation-of-effective-adjuvants-and-antigen-delivery-systems
#5
REVIEW
Nina Sanina, Natalia Chopenko, Andrey Mazeika, Eduard Kostetsky
New generation vaccines, based on isolated antigens, are safer than traditional ones, comprising the whole pathogen. However, major part of purified antigens has weak immunogenicity. Therefore, elaboration of new adjuvants, more effective and safe, is an urgent problem of vaccinology. Tubular immunostimulating complexes (TI-complexes) are a new type of nanoparticulate antigen delivery systems with adjuvant activity. TI-complexes consist of cholesterol and compounds isolated from marine hydrobionts: cucumarioside A2-2 (CDA) from Cucumaria japonica and monogalactosyldiacylglycerol (MGDG) from marine algae or seagrass...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28734166/naturally-occurring-immunomodulators-with-antitumor-activity-an-insight-on-their-mechanisms-of-action
#6
REVIEW
Shimaa Ibrahim Abdelmonym Mohamed, Ibrahim Jantan, Md Areeful Haque
Natural products with immunomodulatory activity are widely used in treatment of many diseases including autoimmune diseases, inflammatory disorders in addition to cancer. They gained a great interest in the last decades as therapeutic agents since they provide inexpensive and less toxic products than the synthetic chemotherapeutic agents. Immunomodulators are the agents that have the ability to boost or suppress the host defense response that can be used as a prophylaxis as well as in combination with other therapeutic modalities...
September 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28716129/current-knowledge-on-feline-injection-site-sarcoma-treatment
#7
REVIEW
Katarzyna Zabielska-Koczywąs, Anna Wojtalewicz, Roman Lechowski
Feline injection-site sarcomas (FISS) are malignant skin tumours of mesenchymal origin, the treatment of which is a challenge for veterinary surgeons. The role of surgery, radiotherapy and chemotherapy in FISS treatment has been studied, and a correlation between "clean" surgical margins and disease-free survival has been shown. In addition, clean surgical margins are one of the most important factors for achieving a low recurrence rate. The most effective method of FISS treatment includes combining radical surgery with pre- or postoperative radiotherapy...
July 17, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28666865/different-%C3%AE-glucans-improve-the-growth-performance-and-bacterial-resistance-in-nile-tilapia
#8
Fabiana Pilarski, Carlos Alberto Ferreira de Oliveira, Fernanda Patrícia Brito Darpossolo de Souza, Fábio Sabbadin Zanuzzo
The role of glucan as a biologically active immunomodulator has been well documented for more than 40 years. However, the wide diversity of β-glucan forms and the extraction process has implications for the benefits of these compounds. Biorigin developed two samples of β-glucans using different biotechnological processes. Thus, in the present study, we fed Nile tilapia (Oreochromis niloticus) diets containing these two β-glucan molecules (BG01 and BG02) for 30 days prior to bacterial infection with Streptococcus agalactiae...
November 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28657707/identification-of-biologically-active-pyrimido-5-4-b-indoles-that-prolong-nf-%C3%AE%C2%BAb-activation-without-intrinsic-activity
#9
Michael Chan, Alast Ahmadi, Shiyin Yao, Fumi Sato-Kaneko, Karen Messer, Minya Pu, Brandon Nguyen, Tomoko Hayashi, Maripat Corr, Dennis A Carson, Howard B Cottam, Nikunj M Shukla
Most vaccine adjuvants directly stimulate and activate antigen presenting cells but do not sustain immunostimulation of these cells. A high throughput screening (HTS) strategy was designed to identify compounds that would sustain NF-κB activation by a stimulus from the Toll-like receptor (TLR)4 ligand, lipopolysaccharide (LPS). Several pilot studies optimized the parameters and conditions for a cell based NF-κB reporter assay in human monocytic THP-1 cells. The final assay evaluated prolongation of LPS induced NF-κB activation at 12 h...
August 14, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28605319/medicinal-mushrooms-in-human-clinical-studies-part-i-anticancer-oncoimmunological-and-immunomodulatory-activities-a-review
#10
Solomon P Wasser
More than 130 medicinal functions are thought to be produced by medicinal mushrooms (MMs) and fungi, including antitumor, immunomodulating, antioxidant, radical scavenging, cardiovascular, antihypercholesterolemic, antiviral, antibacterial, antiparasitic, antifungal, detoxification, hepatoprotective, antidiabetic, and other effects. Many, if not all, higher Basidiomycetes mushrooms contain biologically active compounds in fruit bodies, cultured mycelia, and cultured broth. Special attention has been paid to mushroom polysaccharides...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/28598600/protein-free-hapten-carbon-nanotube-constructs-induce-the-secondary-immune-response
#11
Eric Ceballos-Alcantarilla, Antonio Abad-Somovilla, Consuelo Agulló, Antonio Abad-Fuentes, Josep V Mercader
Carbon nanotubes are novel technological tools with multiple applications. The interaction between such nanoparticles and living organisms is nowadays a matter of keen research by academic and private institutions. In this study, carbon nanotube constructs were investigated as delivery vehicles for immunostimulation and induction of the secondary immune response to a small organic molecule, namely, a hapten. Two types of nanoconstructs were prepared: on one hand, carbon nanotubes carrying a protein bioconjugate of a hapten covalently linked to the carbon surface, and on the other hand, covalent carbon nanotube constructs of the same model chemical compound without the carrier protein...
June 21, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28582454/insights-on-the-mechanism-of-action-of-immunostimulants-in-relation-to-their-pharmacological-potency-the-effects-of-imidazoquinolines-on-tlr8
#12
Carlos Kubli-Garfias, Ricardo Vázquez-Ramírez, Cynthia Trejo-Muñoz, Arturo Berber
Imidazoquinolines are powerful immunostimulants (IMMS) that function through Toll-like receptors, particularly TLR7 and TLR8. In addition to enhancing the immune response, IMMS also function as antineoplastic drugs and vaccine adjuvants. These small compounds display almost the same molecular structure, except in some cases in which atom in position 1 varies and changes the imidazole characteristics. A variable acyclic side chain is also always attached at atom in position 2, while another chain may be attached at atom in position 1...
2017: PloS One
https://www.readbyqxmd.com/read/28580799/flavonoids-of-alcea-rosea-l-and-their-immune-stimulant-antioxidant-and-cytotoxic-activities-on-hepatocellular-carcinoma-hepg-2-cell-line
#13
Nabil A Abdel-Salam, Nabila M Ghazy, Shaimaa M Sallam, Mohamed M Radwan, Amira S Wanas, Mahmoud A ElSohly, Maha A El-Demellawy, Nevin M Abdel-Rahman, Sonia Piacente, Mary L Shenouda
Alcea rosea L. is widely cultivated in gardens of Egypt as an ornamental plant and it has a great history of folkloric medicinal uses. In the present work, phytochemical investigation of the alcoholic extract of the flowers of A. rosea L. led to the isolation of six flavonoids (1-6). Dihydrokaempferol-4'-O-β-d-glucopyranoside (1), dihydrokaempferol (2), kaempferol-3-O-[6″-(E-coumaroyl)]-β-d-glucopyranoside (3), kaempferol-3-O-β-d-glucopyranoside (4), Apigenin (5) and kaempferol-3-O-α-l-rhamnopyranosyl-(1'″→6″)-β-d-glucopyranoside (6)...
June 5, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28528516/combined-effects-of-chinese-medicine-feed-and-ginger-extract-bath-on-co-infection-of-ichthyophthirius-multifiliis-and-dactylogyrus-ctenopharyngodonid-in-grass-carp
#14
Yao-Wu Fu, Bin Wang, Qi-Zhong Zhang, De-Hai Xu, De-Jie Lin, Xing-Ya Yang, Shu-Qun Zhu, Jing-Yang Pan, Qian Deng, Yan-Meng Liu, Sheng-Yu Zhou
Dactylogyrus ctenopharyngodonid and Ichthyophthirius multifiliis are two important ectoparasites of freshwater fish. Co-infection by the two parasites leads to high fish mortality and results in heavy economic losses. This study aimed to evaluate the efficacy of medicated feed and a ginger extract bath against D. ctenopharyngodonid and I. multifiliis on grass carp and investigate the hematological response of grass carp co-infected by the two parasites. These results demonstrated that red blood cell (RBC) and thrombocyte percentage among leucocytes significantly decreased after grass carp were co-infected by D...
July 2017: Parasitology Research
https://www.readbyqxmd.com/read/28526570/role-of-medicinal-plants-on-growth-performance-and-immune-status-in-fish
#15
REVIEW
Elham Awad, Amani Awaad
Disease outbreaks increase proportionally with increases in intensive aquaculture. Natural products including medicinal plants have been known from thousands of years for treating some human diseases. It is well known that many active compounds are responsible for potential bio-activities. For that reason, there has been considerable interest in the use of medicinal plants in aquaculture with a view to providing safe and eco-friendly compounds for replacing antibiotics and chemical compounds as well as to enhance immune status and control fish diseases...
August 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28487429/rationally-designed-tlr4-ligands-for-vaccine-adjuvant-discovery
#16
Kelsey A Gregg, Erin Harberts, Francesca M Gardner, Mark R Pelletier, Corinne Cayatte, Li Yu, Michael P McCarthy, Jason D Marshall, Robert K Ernst
Adjuvant properties of bacterial cell wall components like MPLA (monophosphoryl lipid A) are well described and have gained FDA approval for use in vaccines such as Cervarix. MPLA is the product of chemically modified lipooligosaccharide (LOS), altered to diminish toxic proinflammatory effects while retaining adequate immunogenicity. Despite the virtually unlimited number of potential sources among bacterial strains, the number of useable compounds within this promising class of adjuvants are few. We have developed bacterial enzymatic combinatorial chemistry (BECC) as a method to generate rationally designed, functionally diverse lipid A...
May 9, 2017: MBio
https://www.readbyqxmd.com/read/28365448/synthesis-and-biological-activities-of-c-glycosides-of-krn-7000-with-novel-ceramide-residues
#17
Ahmad S Altiti, Xiaojing Ma, Lixing Zhang, Yi Ban, Richard W Franck, David R Mootoo
The identification of immunoactive agents for clinical and mechanistic applications is a very active area of research. In this vein, analogues of the potent immunostimulant KRN 7000 with diverse cytokine profiles have attracted considerable attention. These compounds have been shown to activate iNKT cells via presentation by CD1d. Herein, we report on the synthesis and activity for four new C-glycosides of KRN 7000, 11-phenylundecanoyl and 11-p-fluorophenylundecanoyl derivatives of C-KRN 7000, 2,3-bis-epi-C-KRN 7000 and the reverse amide of C-KRN 7000...
April 18, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/28182098/antioxidant-immunomodulating-and-microbial-modulating-activities-of-the-sustainable-and-ecofriendly-spirulina
#18
REVIEW
Alberto Finamore, Maura Palmery, Sarra Bensehaila, Ilaria Peluso
The highly nutritional and ecofriendly Spirulina (Arthrospira platensis) has hypolipidemic, hypoglycemic, and antihypertensive properties. Spirulina contains functional compounds, such as phenolics, phycocyanins, and polysaccharides, with antioxidant, anti-inflammatory, and immunostimulating effects. Studies conducted on Spirulina suggest that it is safe in healthy subjects, but attitude to eating probably affects the acceptability of Spirulina containing foods. Although the antioxidant effect of Spirulina is confirmed by the intervention studies, the concerted modulation of antioxidant and inflammatory responses, suggested by in vitro and animal studies, requires more confirmation in humans...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28013001/mitochondrial-functions-of-thp-1-monocytes-following-the-exposure-to-selected-natural-compounds
#19
Nadin Schultze, Heike Wanka, Paula Zwicker, Ulrike Lindequist, Beate Haertel
The immune system is an important target of various xenobiotics, which may lead to severe adverse effects including immunosuppression or inappropriate immunostimulation. Mitochondrial toxicity is one possibility by which xenobiotics exert their toxic effects in cells or organs. In this study, we investigated the impact of three natural compounds, cyclosporine A (CsA), deoxynivalenol (DON) and cannabidiol (CBD) on mitochondrial functions in the THP-1 monocytic cell line. The cells were exposed for 24h to two different concentrations (IC10 and IC50 determined by MTT) of each compound...
February 15, 2017: Toxicology
https://www.readbyqxmd.com/read/27987189/immunomodulatory-properties-of-filamentous-fungi-cultivated-through-solid-state-fermentation-on-rapeseed-meal
#20
Stéphanie Sutter, France Thevenieau, Anne Bourdillon, Joëlle De Coninck
Water extracts from solid-state fermentation (SSF) on rapeseed meal using filamentous fungi exhibit interesting immunomodulatory activities in vitro. Immunomodulation was determined by the capacity of the compounds to activate blood neutrophils and to influence cytokine production in human peripheral blood mononuclear cells (PBMC) and mouse bone marrow-derived macrophages (BMDM). Among the strains tested, Aspergillus sojae mycelium and SSF extracts were the most promising in terms of enhancing the immune response...
July 2017: Applied Biochemistry and Biotechnology
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