keyword
MENU ▼
Read by QxMD icon Read
search

Immunostimulating compound

keyword
https://www.readbyqxmd.com/read/27776125/immunotherapeutic-potential-of-eugenol-emulsion-in-experimental-visceral-leishmaniasis
#1
Mohammad Islamuddin, Garima Chouhan, Muzamil Yaqub Want, Hani A Ozbak, Hassan A Hemeg, Farhat Afrin
BACKGROUND: The therapy of visceral leishmaniasis (VL) is limited by resistance, toxicity and decreased bioavailability of the existing drugs coupled with dramatic increase in HIV-co-infection, non-availability of vaccines and down regulation of cell-mediated immunity (CMI). Thus, we envisaged combating the problem with plant-derived antileishmanial drug that could concomitantly mitigate the immune suppression of the infected hosts. Several plant-derived compounds have been found to exert leishmanicidal activity via immunomodulation...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27775618/effects-of-saponins-on-lipid-metabolism-a-review-of-potential-health-benefits-in-the-treatment-of-obesity
#2
Mariangela Marrelli, Filomena Conforti, Fabrizio Araniti, Giancarlo A Statti
Obesity is one of the greatest public health problems. This complex condition has reached epidemic proportions in many parts of the world, and it constitutes a risk factor for several chronic disorders, such as hypertension, cardiovascular diseases and type 2 diabetes. In the last few decades, several studies dealt with the potential effects of natural products as new safe and effective tools for body weight control. Saponins are naturally-occurring surface-active glycosides, mainly produced by plants, whose structure consists of a sugar moiety linked to a hydrophobic aglycone (a steroid or a triterpene)...
October 20, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27751916/dietary-phytoimmunostimulant-persian-hogweed-heracleum-persicum-has-more-remarkable-impacts-on-skin-mucus-than-on-serum-in-common-carp-cyprinus-carpio
#3
Seyed Hossein Hoseinifar, Fazel Zoheiri, Carlo C Lazado
Immunostimulation through the use of sustainable and eco-friendly dietary additives is one of the current prophylactic strategies in fish husbandry. Plant-based immunostimulants are highly considered for this intent, both for their scientific and practical advantages. Persian hogweed (Heracleum persicum) is a flower-bearing herb that possesses interesting pharmacological importance due to its bioactive compounds. It is commonly used as spice, food additive, dietary supplement and traditional remedy. The present study evaluated the potential of H...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27742478/vizantin-inhibits-bacterial-adhesion-without-affecting-bacterial-growth-and-causes-streptococcus-mutans-biofilm-to-detach-by-altering-its-internal-architecture
#4
Shoji Takenaka, Masataka Oda, Hisanori Domon, Tatsuya Ohsumi, Yuki Suzuki, Hayato Ohshima, Hirofumi Yamamoto, Yutaka Terao, Yuichiro Noiri
An ideal antibiofilm strategy is to control both in the quality and quantity of biofilm while maintaining the benefits derived from resident microflora. Vizantin, a recently developed immunostimulating compound, has also been found to have antibiofilm property. This study evaluated the influence on biofilm formation of Streptococcus mutans in the presence of sulfated vizantin and biofilm development following bacterial adhesion on a hydroxyapatite disc coated with sulfated vizantin. Supplementation with sulfated vizantin up to 50 μM did not affect either bacterial growth or biofilm formation, whereas 50 μM sulfated vizantin caused the biofilm to readily detach from the surface...
October 11, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27687999/a-proteomic-approach-for-the-identification-of-immunotoxic-properties-of-tulipalin-a
#5
Paula Zwicker, Nadin Schultze, Sarah Niehs, Karen Methling, Martina Wurster, Dirk Albrecht, Jörg Bernhardt, Gerhild Wachlin, Michael Lalk, Ulrike Lindequist, Beate Haertel
The immune system is permanently exposed to several environmental influences that can have adverse effects on immune cells or organs leading to immunosuppression or inappropriate immunostimulation, called direct immunotoxicity. The natural compound Tulipalin A (TUPA), a lactone with α-methylene-γ-butyrolactone moiety, can influence the immune system and lead to allergic contact dermatitis. This in vitro study focused on effects of TUPA using two immune cell lines (Jurkat T cells and THP-1 monocytes). To evaluate the immunotoxic potential of the compound, a proteomic approach applying 2D gel electrophoresis and MALDI-TOF/TOF-MS in combination with metabolomic analysis was used after exposure of the cells to IC10 of TUPA...
September 30, 2016: Proteomics
https://www.readbyqxmd.com/read/27633680/polysaccharides-from-marine-macroalga-padina-gymnospora-improve-the-nonspecific-and-specific-immune-responses-of-cyprinus-carpio-and-protect-it-from-different-pathogens
#6
Priyatharsini Rajendran, Parasuraman Aiya Subramani, Dinakaran Michael
Immunostimulation by plant-derived compounds presents a fascinating alternative to vaccines and antibiotics in aquaculture. Fish farmers are longing for immunostimulants that activate both specific and nonspecific immune responses of fish and protect fishes from all possible infections. In this study, we observed that polysaccharide fraction from marine macroalga, Padina gymnospora stimulated the immune response of common carp Cyprinus carpio (Filed for patent, Indian patent no. 201641027311 dated:10-Aug-2016)...
September 12, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27583251/applications-of-in-ovo-technique-for-the-optimal-development-of-the-gastrointestinal-tract-and-the-potential-influence-on-the-establishment-of-its-microbiome-in-poultry
#7
REVIEW
Stephanie M Roto, Young Min Kwon, Steven C Ricke
As the current poultry production system stands, there is a period of time when newly hatched chicks are prevented from access to feed for approximately 48-72 h. Research has indicated that this delay in feeding may result in decreased growth performance when compared to chicks that are fed immediately post-hatch. To remedy this issue, in ovo methodology may be applied in order to supply the embryo with additional nutrients prior to hatching and those nutrients will continue to be utilized by the chick post-hatch during the fasting period...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27510009/in-vitro-studies-on-phytochemical-content-antioxidant-anticancer-immunomodulatory-and-antigenotoxic-activities-of-lemon-grapefruit-and-mandarin-citrus-peels
#8
Kawthar Ae Diab
BACKGROUND: In recent years, there has been considerable research on recycling of agroindustrial waste for production of bioactive compounds. The food processing industry produces large amounts of citrus peels that may be an inexpensive source of useful agents. OBJECTIVE: The present work aimed to explore the phytochemical content, antioxidant, anticancer, antiproliferation, and antigenotxic activities of lemon, grapefruit, and mandarin peels. MATERIALS AND METHODS: Peels were extracted using 98% ethanol and the three crude extracts were assessed for their total polyphenol content (TPC), total flavonoid content (TFC), and antioxidant activity using DPPH (1, 1diphenyl2picrylhydrazyl)...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27502390/nanocarriers-as-tools-in-delivering-active-compounds-for-immune-system-related-pathologies
#9
REVIEW
Codruta Soica, Dorina Coricovac, Cristina Dehelean, Iulia Pinzaru, Marius Mioc, Corina Danciu, Adriana Fulias, Maria Puiu, Cassian Sitaru
BACKGROUND: Immune system related pathologies affect an increasing number of patients every year, having potentially lethal consequences and requiring expensive and difficult tolerated treatments. This area of pathologies offers an excellent potential for the development of innovative solutions such as nanoformulations; this review aims to describe the main categories of nanostructured drug delivery platforms that have been developed in order to achieve a more effective, low toxic treatment in autoimmune pathologies...
2016: Recent Patents on Nanotechnology
https://www.readbyqxmd.com/read/27498344/a-bifunctional-approach-of-immunostimulation-and-upar-inhibition-shows-potent-antitumor-activity-in%C3%A2-melanoma
#10
Fanny Matheis, Markus V Heppt, Saskia A Graf, Peter Düwell, Claudia Kammerbauer, Achim Aigner, Robert Besch, Carola Berking
Significant advancements of mutation-based targeted therapy and immune checkpoint blockade have been achieved in melanoma. Nevertheless, acquired resistance and nonresponders to therapy require different strategies. An innovative approach is presented here that is based on the combination of innate immune system activation and simultaneous targeting of the oncogene urokinase-type plasminogen activator receptor (uPAR). We generated two triphosphate-conjugated siRNAs targeting uPAR (ppp-uPAR) by in vitro transcription...
August 3, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27485839/the-fungal-resistome-a-risk-and-an-opportunity-for-the-development-of-novel-antifungal-therapies
#11
Jose A Reales-Calderón, Gloria Molero, Concha Gil, José L Martínez
The risks for toxicity of novel antifungal compounds, together with the emergence of resistance, makes the use of inhibitors of resistance, in combination with antifungal compounds, a suitable strategy for developing novel antifungal formulations. Among them, inhibitors of efflux pumps are suitable candidates. Increasing drug influx or interfering with the stress response may also improve the efficacy of antifungals. Therapies as induction of fungal apoptosis or immunostimulation are also good strategies for reducing the risks for resistance and to improve antifungals' efficacy...
August 2016: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/27474926/synthesis-and-immunopotentiating-activity-of-novel-isoxazoline-functionalized-coumarins
#12
Tabasum Ismail, Syed Shafi, Swarn Singh, Tabasum Sidiq, Anamika Khajuria, Abdul Rouf, Mahipal Yadav, Varma Saikam, Parvinder Pal Singh, Mohammad Sarwar Alam, Nasarul Islam, Kalicharan Sharma, Halmuthur Mahabalarao Sampath Kumar
A novel series (13) of isoxazoline functionalized coumarins was synthesized through 1,3-dipolar cyclization of nitrile oxides with Allylated coumarins. Synthesis of effective and target selective immunostimulators through conjugation of diversely substituted isoxazolines and 7-hydroxycoumarins is the focus of the present article. The proposed synthetic scheme was observed to be highly regiospecific yielding attempted conjugates in good yield (>90%). Kinetic resolution of the racemates was carried out by employing lipase B from Candida antarctica (CALB)...
November 10, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27387399/in-vivo-antitumor-effect-induction-of-apoptosis-and-safety-of-remirea-maritima-aubl-cyperaceae-extracts
#13
Grace Anne A Dória, Paula P Menezes, Bruno S Lima, Bruno S Vasconcelos, Francilene A Silva, Raíssa M Henriques, Marcélia G D Melo, Ângela V F Alves, Manoel O Moraes, Cláudia Ó Pessoa, Adriana A Carvalho, Ana Paula N Prata, Ricardo Luiz C A Junior, Isabel B Lima-Verde, Lucindo J Quintans-Júnior, Daniel P Bezerra, Paulo C L Nogueira, Adriano A S Araujo
BACKGROUND: Remirea maritima has been widely used in the treatment of diarrhea, kidney disease, and high fever and for therapeutic purposes, such as an analgesic and anti-inflammatory. However, few scientific research studies on its medicinal properties have been reported. PURPOSE: The present study aimed to investigate the anticancer potential of aqueous extract (AE), 40% hydroalcoholic extracts (40HA) and 70% (70HA) from R. maritima in experimental models and to identify its phytochemical compounds...
August 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27377146/nano-self-assemblies-based-on-synthetic-analogues-of-mycobacterial-monomycoloyl-glycerol-and-dda-supramolecular-structure-and-adjuvant-efficacy
#14
Birte Martin-Bertelsen, Karen S Korsholm, Carla B Roces, Maja H Nielsen, Dennis Christensen, Henrik Franzyk, Anan Yaghmur, Camilla Foged
The mycobacterial cell-wall lipid monomycoloyl glycerol (MMG) is a potent immunostimulator, and cationic liposomes composed of a shorter synthetic analogue (MMG-1) and dimethyldioctadecylammonium (DDA) bromide represent a promising adjuvant that induces strong antigen-specific Th1 and Th17 responses. In the present study, we investigated the supramolecular structure and in vivo adjuvant activity of dispersions based on binary mixtures of DDA and an array of synthetic MMG-1 analogues (MMG-2/3/5/6) displaying longer (MMG-2) or shorter (MMG-3) alkyl chain lengths, or variations in stereochemistry of the polar headgroup (MMG-5) or of the hydrophobic moiety (MMG-6)...
August 1, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27333382/vitamin-e-for-the-treatment-of-e-antigen-positive-chronic-hepatitis-b-in-pediatric-patients-results-of-a-randomized-phase-2-controlled-study
#15
Sirio Fiorino, Elisabetta Loggi, Gabriella Verucchi, Donatella Comparcola, Ranka Vukotic, Michele Pavoni, Elena Grandini, Carmela Cursaro, Silvia Maselli, Maria Letizia Bacchi Reggiani, Cristina Puggioli, Lorenzo Badia, Silvia Galli, Pierluigi Viale, Mauro Bernardi, Pietro Andreone
BACKGROUND & AIMS: The treatment of chronic hepatitis B infection (CHB) in children is still an area of great uncertainty. Vitamin E is an immunostimulating/antioxidant compound proven to be safe and effective for the treatment of adult CHB. The aim of this phase 2 controlled study was to evaluate the safety and efficacy of vitamin E for the treatment of pediatric HBeAg-positive CHB. METHODS: Forty-six children were randomized in a 1:1 ratio to receive vitamin E at a dose of 15 mg/kg/day (in galenic preparation) or no treatment for 12 months and were monitored for the subsequent 12 months...
June 22, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27233924/special-endpoint-and-product-specific-considerations-in-pharmaceutical-acceptable-daily-exposure-derivation
#16
Janet Gould, Courtney M Callis, David G Dolan, Brad Stanard, Patricia A Weideman
Recently, a guideline has been published by the European Medicines Agency (EMA) on setting safe limits, permitted daily exposures (PDE) [also called acceptable daily exposures (ADE)], for medicines manufactured in multi-product facilities. The ADE provides a safe exposure limit for inadvertent exposure of a drug due to cross-contamination in manufacturing. The ADE determination encompasses a standard risk assessment, requiring an understanding of the toxicological and pharmacological effects, the mechanism of action, drug compound class, and the dose-response as well as the pharmacokinetic properties of the compound...
August 2016: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/27095922/in-vivo-anticancer-and-immunomodulating-activities-of-mannogalactoglucan-type-polysaccharides-from-lentinus-edodes-berkeley-singer
#17
Iteku Bekomo Jeff, Enxue Fan, Meihong Tian, Chenyang Song, Jingmin Yan, Yifa Zhou
There is considerable interest in the potential of mushrooms in modulating the immune system and/or suppressing tumor growth. Among the studied bioactive compounds in mushrooms, polysaccharides are the most important. Nontoxic fungal polysaccharides have a more important role in immunomodulating and antitumor activities which are related to their effects to act of immune effecter cells such as lymphocytes, macrophages, dendritic cells, and natural killer cells involved in the innate and adaptive immunity. Two mannogalactoglucan-type polysaccharides (WPLE-N-2 and WPLE-A0...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27082979/design-and-synthesis-of-structure-simplified-derivatives-of-gonytolide-for-the-promotion-of-innate-immune-responses
#18
Haruhisa Kikuchi, Tsuyoshi Hoshikawa, Shoichiro Kurata, Yasuhiro Katou, Yoshiteru Oshima
Gonytolide A (1), a dimeric chromanone substituted with the γ-lactone, shows promoting activity of innate immune responses. However, biological studies on this compound have been limited by the low amounts of 1 available from natural resources and the difficulty of its synthesis. In this study, we designed and synthesized structure-simplified gonytolide derivatives. Bischromone 10 and biflavone 13 both promoted the mammalian TNF-α signaling pathway and Drosophila innate immunity. They did not contain a chiral center and were easy to synthesize...
May 27, 2016: Journal of Natural Products
https://www.readbyqxmd.com/read/27057104/peperomia-pellucida-leaf-extract-as-immunostimulator-in-controlling-motile-aeromonad-septicemia-due-to-aeromonas-hydrophila-in-red-hybrid-tilapia-oreochromis-spp-farming
#19
S W Lee, K Y Sim, W Wendy, A K Zulhisyam
AIM: This study was revealed the potential of Peperomia pellucida leaf extract as an immunostimulator agent in controlling motile aeromonad septicemia due to Aeromonas hydrophila in red hybrid tilapia, Oreochromis sp. MATERIALS AND METHODS: In the present study, minimum inhibitory concentration (MIC) of P. pellucida leaf extract against A. hydrophila was determined through two-fold microbroth dilution method. The plant extract was screening for its active compound using a gas chromatograph mass spectrometer, and the effectiveness of P...
March 2016: Veterinary World
https://www.readbyqxmd.com/read/27042188/medicinal-plants-from-mexico-central-america-and-the-caribbean-used-as-immunostimulants
#20
REVIEW
Angel Josabad Alonso-Castro, María Del Carmen Juárez-Vázquez, Nimsi Campos-Xolalpa
A literature review was undertaken by analyzing distinguished books, undergraduate and postgraduate theses, and peer-reviewed scientific articles and by consulting worldwide accepted scientific databases, such as SCOPUS, Web of Science, SCIELO, Medline, and Google Scholar. Medicinal plants used as immunostimulants were classified into two categories: (1) plants with pharmacological studies and (2) plants without pharmacological research. Medicinal plants with pharmacological studies of their immunostimulatory properties were subclassified into four groups as follows: (a) plant extracts evaluated for in vitro effects, (b) plant extracts with documented in vivo effects, (c) active compounds tested on in vitro studies, and (d) active compounds assayed in animal models...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
keyword
keyword
108953
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"