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David healy

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https://www.readbyqxmd.com/read/28297429/method-and-phantom-to-study-combined-effects-of-in-plane-x-y-and-z-axis-resolution-for-3d-ct-imaging
#1
David Goodenough, Josh Levy, Smari Kristinsson, Jesper Fredriksson, Hildur Olafsdottir, Austin Healy
Increasingly, the advent of multislice CT scanners, volume CT scanners, and total body spiral acquisition modes has led to the use of Multi Planar Reconstruction and 3D datasets. In considering 3D resolution properties of a CT system it is important to note that both the in-plane (x,y) and z-axis (slice thickness) influence the visualization and detection of objects within the scanned volume. This study investigates ways to consider both the in-plane resolution and the z-axis resolution in a single phantom wherein analytic or visualized analysis can yield information on these combined effects...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28264684/intervening-to-reduce-workplace-sitting-mediating-role-of-social-cognitive-constructs-during-a-cluster-randomised-controlled-trial
#2
Nyssa T Hadgraft, Elisabeth A H Winkler, Genevieve N Healy, Brigid M Lynch, Maike Neuhaus, Elizabeth G Eakin, David W Dunstan, Neville Owen, Brianna S Fjeldsoe
BACKGROUND: The Stand Up Victoria multi-component intervention successfully reduced workplace sitting time in both the short (three months) and long (12 months) term. To further understand how this intervention worked, we aimed to assess the impact of the intervention on four social-cognitive constructs, and examined whether these constructs mediated intervention effects on workplace sitting time at 3 and 12 months post-baseline. METHODS: Two hundred and thirty one office-based workers (14 worksites, single government employer) were randomised to intervention or control conditions by worksite...
March 6, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28240701/12-year-television-viewing-time-trajectories-and-physical-function-in-older-adults
#3
Natasha Reid, Genevieve N Healy, Robin M Daly, Peter Baker, Elizabeth G Eakin, David W Dunstan, Neville Owen, Paul A Gardiner
INTRODUCTION: The purpose of this study was to identify trajectories of older adults' television viewing (TV) time over 12 years; and, to examine their associations with performance-based measures of physical function. METHODS: Data on TV time (hours/week) and socio-demographic factors were collected at each assessment of the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study (1999/2000; 2004/2005; 2011/2012), with objective measures of physical function (2...
February 25, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28229911/diagnostic-accuracy-of-carotid-intima-media-thickness-in-predicting-coronary-plaque-burden-on-coronary-computed-tomography-angiography-in-patients-with-obstructive-sleep-apnoea
#4
David J Murphy, Sophie J Crinion, Ciaran E Redmond, Gerard M Healy, Walter T McNicholas, Silke Ryan, Jonathan D Dodd
AIM: To assess the diagnostic accuracy of common carotid artery intima media thickness (CIMT) for coronary artery disease (CAD) detection in patients with obstructive sleep apnoea (OSA). MATERIALS & METHODS: Patients with clinically suspected OSA prospectively underwent polysomnography (PSG), ultrasound CIMT measurement and coronary computed tomography angiography (CTA). An average CIMT of ≥0.9 mm in either common carotid artery designated as a positive test...
February 11, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28215353/a-molecular-and-morphological-re-examination-of-the-generic-limits-of-truffles-in-the-tarzetta-geopyxis-lineage-densocarpa-hydnocystis-and-paurocotylis
#5
Leticia M Kumar, Matthew E Smith, Eduardo R Nouhra, Takamichi Orihara, Pablo Sandoval Leiva, Donald H Pfister, David J McLaughlin, James M Trappe, Rosanne A Healy
Truffle species within the /tarzetta-geopyxis lineage share smooth, globose, hyaline spores, but differ in the amount of convolution of hymenia in ascomata. The relationships among truffle species in this lineage have historically been confused. Phylogenetic analyses of the ITS and 28S nuclear ribosomal DNA from recently collected members of the /tarzetta-geopyxis lineage from Asia, Austral Asia, North America, and South America prompted a reinvestigation of species and generic limits in the truffle genera Hydnocystis, Paurocotylis, and Stephensia...
March 2017: Fungal Biology
https://www.readbyqxmd.com/read/28214359/gene-expression-plasticity-in-response-to-salinity-acclimation-in-threespine-stickleback-ecotypes-from-different-salinity-habitats
#6
Taylor C Gibbons, David C H Metzger, Timothy M Healy, Patricia M Schulte
Phenotypic plasticity is thought to facilitate the colonization of novel environments and shape the direction of evolution in colonizing populations. However, the relative prevalence of various predicted patterns of changes in phenotypic plasticity following colonization remain unclear. Here we use a whole-transcriptome approach to characterize patterns of gene expression plasticity in the gills of a freshwater-adapted and a saltwater-adapted ecotype of threespine stickleback (Gasterosteus aculeatus) exposed to a range of salinities...
February 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28175613/369%C3%A2-chimeric-antigen-receptors-deficient-in-lck-signaling-require-4-1bb-costimulation-to-expand-in-vivo-resist-regulatory-t-cell-suppression-and-treat-solid-tumors-in-immune-intact-hosts
#7
Carter M Suryadevara, Rupen Desai, Samuel Harrison Farber, Patrick C Gedeon, Adam Swartz, David Snyder, James Herndon, Patrick Healy, Bryan D Choi, Peter Edward Fecci, Luis Sanchez-Perez, John H Sampson
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28166892/a-qualitative-review-of-existing-national-and-international-occupational-safety-and-health-policies-relating-to-occupational-sedentary-behaviour
#8
REVIEW
Pieter Coenen, Nicholas Gilson, Genevieve N Healy, David W Dunstan, Leon M Straker
Prolonged sedentary time is now recognised as an emergent ergonomics issue. We aimed to review current occupational safety and health policies relevant to occupational sedentary behaviour. An electronic search for documents was conducted on websites of ergonomics and occupational safety and health organisations from 10 countries and six international/pan-European agencies. Additionally, 43 informants (nine countries) were contacted and an international conference workshop held. 119 documents (e.g. legislation, guidelines, codes of practice) were identified...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28165177/intrauterine-death-rate-in-gastroschisis-following-the-introduction-of-an-antenatal-surveillance-program-retrospective-observational-study
#9
Helen Perry, Costa Healy, Diana Wellesley, Nigel J Hall, Melanie Drewett, David M Burge, David T Howe
AIM: To investigate whether an antenatal surveillance protocol including ultrasound and cardiotocograph monitoring reduces intrauterine death (IUD) in cases of gastroschisis. Secondary outcomes included neonatal death rate, mode of delivery and rate of intervention before planned time of delivery. METHODS: This was a retrospective observational study of all women with antenatally diagnosed gastroschisis who were managed according to the surveillance program between 2002 and 2015 in a tertiary fetal medicine and pediatric surgical center covering the Wessex region of England...
February 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28160292/preoperative-%C3%AE-blockade-and-hypertension-in-the-first-hour-of-functional-endoscopic-sinus-surgery
#10
Samuel A Schechtman, Aileen P Wertz, Amy Shanks, Aleda Thompson, Kevin Tremper, Melissa A Pynnonen, David W Healy
OBJECTIVES/HYPOTHESIS: Local anesthetic with epinephrine is commonly injected into the nasal mucosa during functional endoscopic sinus surgery (FESS). Systemic absorption of epinephrine following local injection may occur, resulting in a mild sympathetic response. This study seeks to determine whether an exaggerated sympathetic response to epinephrine is demonstrated in patients undergoing FESS treated preoperatively with established pharmacologic beta (β) adrenoceptor blockade. STUDY DESIGN: A retrospective analysis of adult patients undergoing FESS at a tertiary care university hospital...
February 3, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28131163/the-test-accuracy-of-the-montreal-cognitive-assessment-moca-by-stroke-lateralisation
#11
Edgar Chan, Samantha Altendorff, Colm Healy, David J Werring, Lisa Cipolotti
BACKGROUND: The Montreal Cognitive Assessment (MoCA) is an increasingly popular screening tool for detecting cognitive impairment post-stroke. However its' test accuracy by stroke lateralisation is as yet unknown. AIM: Our aim was to investigate whether the test accuracy of the MoCA differs by stroke lateralisation across different cognitive domains. METHODS: We retrospectively examined the cognitive profiles of 228 subacute stroke patients (86 Left, 142 Right), comparing MoCA-total and domain-specific scores with performance on detailed neuropsychological assessment...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28120527/does-diet-mediate-associations-of-volume-and-bouts-of-sedentary-time-with-cardiometabolic-health-indicators-in-adolescents
#12
Elly A Fletcher, Valerie Carson, Sarah A McNaughton, David W Dunstan, Genevieve N Healy, Jo Salmon
OBJECTIVE: Examine the mediating role of diet in the relationship between volume and duration of sedentary time with cardiometabolic health in adolescents. METHODS: Adolescents (12-19 years) participating in the 2003/04 and 2005/06 U.S. National Health and Nutrition Examination Survey (NHANES) were examined. Cardiometabolic health indicators were body mass index z-scores (zBMI) (n = 1,797) and metabolic syndrome (MetS) (n = 812). An ActiGraph hip-worn accelerometer was used to derive total sedentary time and usual sedentary bout duration...
January 25, 2017: Obesity
https://www.readbyqxmd.com/read/28093606/erratum-to-adjusting-foraging-strategies-a-comparison-of-rural-and-urban-common-mynas-acridotheres-tristis
#13
Ira G Federspiel, Alexis Garland, David Guez, Thomas Bugnyar, Susan D Healy, Onur Güntürkün, Andrea S Griffin
No abstract text is available yet for this article.
January 2017: Animal Cognition
https://www.readbyqxmd.com/read/28087821/selection-of-first-line-therapy-in-multiple-sclerosis-using-risk-benefit-decision-analysis
#14
David Bargiela, Matthew T Bianchi, M Brandon Westover, Lori B Chibnik, Brian C Healy, Philip L De Jager, Zongqi Xia
OBJECTIVE: To integrate long-term measures of disease-modifying drug efficacy and risk to guide selection of first-line treatment of multiple sclerosis. METHODS: We created a Markov decision model to evaluate disability worsening and progressive multifocal leukoencephalopathy (PML) risk in patients receiving natalizumab (NTZ), fingolimod (FGL), or glatiramer acetate (GA) over 30 years. Leveraging publicly available data, we integrated treatment utility, disability worsening, and risk of PML into quality-adjusted life-years (QALYs)...
February 14, 2017: Neurology
https://www.readbyqxmd.com/read/28076824/discovery-of-new-nanomolar-inhibitors-of-gpa-extension-of-2-oxo-1-2-dihydropyridinyl-3-yl-amide-based-gpa-inhibitors
#15
Wendy A Loughlin, Ian D Jenkins, N David Karis, Peter C Healy
Glycogen Phosphorylase (GP) is a functionally active dimeric enzyme, which is a target for inhibition of the conversion of glycogen to glucose-1-phosphate. In this study we report the design and synthesis of 14 new pyridone derivatives, and seek to extend the SAR analysis of these compounds. The SAR revealed the minor influence of the amide group, importance of the pyridone ring both spatially around the pyridine ring and for possible π-stacking, and confirmed a preference for inclusion of 3,4-dichlorobenzyl moieties, as bookends to the pyridone scaffold...
February 15, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28063598/burn-injury-influences-the-t-cell-homeostasis-in-a-butyrate-acid-sphingomyelinase-dependent-manner
#16
Teresa C Rice, Stephanie M Armocida, Joshua W Kuethe, Emily F Midura, Ayushi Jain, David A Hildeman, Daniel P Healy, Erich Gulbins, Charles C Caldwell
Following burn injury, a key factor for patients susceptible to opportunistic infections is immune suppression. Butyrate levels are important in maintaining a functional immune system and these levels can be altered after injury. The acid sphingomyelinase (Asm) lipid signaling system has been implicated in a T cell actions with some evidence of being influenced by butyrate. Here, we hypothesized that burn-injury changes in butyrate levels would mediate Asm activity and, consequently, T cell homeostasis. We demonstrate that burn injury temporally decreases butyrate levels...
March 2017: Cellular Immunology
https://www.readbyqxmd.com/read/27941137/tubular-aggregates-and-cylindrical-spirals-have-distinct-immunohistochemical-signatures
#17
Stefen Brady, Estelle G Healy, Qiang Gang, Matt Parton, Ros Quinlivan, Saiju Jacob, Elizabeth Curtis, Safa Al-Sarraj, Caroline A Sewry, Michael G Hanna, Henry Houlden, David Beeson, Janice L Holton
Tubular aggregates and cylindrical spirals are 2 distinct ultrastructural abnormalities observed in muscle biopsies that have similar histochemical staining characteristics on light microscopy. Both are found in a wide range of disorders. Recently, a number of genetic mutations have been reported in conditions with tubular aggregates in skeletal muscle. It is widely accepted that tubular aggregates arise from the sarcoplasmic reticulum, but the origin of cylindrical spirals has been less clearly defined. We describe the histopathological features of myopathies with tubular aggregates, including a detailed immunohistochemical analysis of congenital myasthenic syndromes with tubular aggregates due to mutations in GFPT1 and DPAGT1, and myopathies with cylindrical spirals...
December 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/27884862/associations-of-occupational-standing-with-musculoskeletal-symptoms-a-systematic-review-with-meta-analysis
#18
REVIEW
Pieter Coenen, Lisa Willenberg, Sharon Parry, Joyce W Shi, Lorena Romero, Diana M Blackwood, Christopher G Maher, Genevieve N Healy, David W Dunstan, Leon M Straker
OBJECTIVE: Given the high exposure to occupational standing in specific occupations, and recent initiatives to encourage intermittent standing among white-collar workers, a better understanding of the potential health consequences of occupational standing is required. We aimed to review and quantify the epidemiological evidence on associations of occupational standing with musculoskeletal symptoms. DESIGN: A systematic review was performed. Data from included articles were extracted and described, and meta-analyses conducted when data were sufficiently homogeneous...
November 24, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27849203/erratum-usp15-regulates-type-i-interferon-response-and-is-required-for-pathogenesis-of-neuroinflammation
#19
Sabrina Torre, Maria J Polyak, David Langlais, Nassima Fodil, James M Kennedy, Irena Radovanovic, Joanne Berghout, Gabriel A Leiva-Torres, Connie M Krawczyk, Subburaj Ilangumaran, Karen Mossman, Chen Liang, Klaus-Peter Knobeloch, Luke M Healy, Jack Antel, Nathalie Arbour, Alexandre Prat, Jacek Majewski, Mark Lathrop, Silvia M Vidal, Philippe Gros
No abstract text is available yet for this article.
November 16, 2016: Nature Immunology
https://www.readbyqxmd.com/read/27822056/implementing-interprofessional-bedside-rounding-at-the-prequalification-stage
#20
Daniel R Tuite, David Healy, Thomas S MacKinnon
No abstract text is available yet for this article.
2016: Journal of Multidisciplinary Healthcare
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