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David healy

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https://www.readbyqxmd.com/read/28214359/gene-expression-plasticity-in-response-to-salinity-acclimation-in-threespine-stickleback-ecotypes-from-different-salinity-habitats
#1
Taylor C Gibbons, David C H Metzger, Timothy M Healy, Patricia M Schulte
Phenotypic plasticity is thought to facilitate the colonization of novel environments and shape the direction of evolution in colonizing populations. However, the relative prevalence of various predicted patterns of changes in phenotypic plasticity following colonization remain unclear. Here we use a whole-transcriptome approach to characterize patterns of gene expression plasticity in the gills of a freshwater-adapted and a saltwater-adapted ecotype of threespine stickleback (Gasterosteus aculeatus) exposed to a range of salinities...
February 18, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28175613/369%C3%A2-chimeric-antigen-receptors-deficient-in-lck-signaling-require-4-1bb-costimulation-to-expand-in-vivo-resist-regulatory-t-cell-suppression-and-treat-solid-tumors-in-immune-intact-hosts
#2
Carter M Suryadevara, Rupen Desai, Samuel Harrison Farber, Patrick C Gedeon, Adam Swartz, David Snyder, James Herndon, Patrick Healy, Bryan D Choi, Peter Edward Fecci, Luis Sanchez-Perez, John H Sampson
No abstract text is available yet for this article.
August 1, 2016: Neurosurgery
https://www.readbyqxmd.com/read/28166892/a-qualitative-review-of-existing-national-and-international-occupational-safety-and-health-policies-relating-to-occupational-sedentary-behaviour
#3
REVIEW
Pieter Coenen, Nicholas Gilson, Genevieve N Healy, David W Dunstan, Leon M Straker
Prolonged sedentary time is now recognised as an emergent ergonomics issue. We aimed to review current occupational safety and health policies relevant to occupational sedentary behaviour. An electronic search for documents was conducted on websites of ergonomics and occupational safety and health organisations from 10 countries and six international/pan-European agencies. Additionally, 43 informants (nine countries) were contacted and an international conference workshop held. 119 documents (e.g. legislation, guidelines, codes of practice) were identified...
April 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28165177/intrauterine-death-rate-in-gastroschisis-following-the-introduction-of-an-antenatal-surveillance-program-retrospective-observational-study
#4
Helen Perry, Costa Healy, Diana Wellesley, Nigel J Hall, Melanie Drewett, David M Burge, David T Howe
AIM: To investigate whether an antenatal surveillance protocol including ultrasound and cardiotocograph monitoring reduces intrauterine death (IUD) in cases of gastroschisis. Secondary outcomes included neonatal death rate, mode of delivery and rate of intervention before planned time of delivery. METHODS: This was a retrospective observational study of all women with antenatally diagnosed gastroschisis who were managed according to the surveillance program between 2002 and 2015 in a tertiary fetal medicine and pediatric surgical center covering the Wessex region of England...
February 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28160292/preoperative-%C3%AE-blockade-and-hypertension-in-the-first-hour-of-functional-endoscopic-sinus-surgery
#5
Samuel A Schechtman, Aileen P Wertz, Amy Shanks, Aleda Thompson, Kevin Tremper, Melissa A Pynnonen, David W Healy
OBJECTIVES/HYPOTHESIS: Local anesthetic with epinephrine is commonly injected into the nasal mucosa during functional endoscopic sinus surgery (FESS). Systemic absorption of epinephrine following local injection may occur, resulting in a mild sympathetic response. This study seeks to determine whether an exaggerated sympathetic response to epinephrine is demonstrated in patients undergoing FESS treated preoperatively with established pharmacologic beta (β) adrenoceptor blockade. STUDY DESIGN: A retrospective analysis of adult patients undergoing FESS at a tertiary care university hospital...
February 3, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28131163/the-test-accuracy-of-the-montreal-cognitive-assessment-moca-by-stroke-lateralisation
#6
Edgar Chan, Samantha Altendorff, Colm Healy, David J Werring, Lisa Cipolotti
BACKGROUND: The Montreal Cognitive Assessment (MoCA) is an increasingly popular screening tool for detecting cognitive impairment post-stroke. However its' test accuracy by stroke lateralisation is as yet unknown. AIM: Our aim was to investigate whether the test accuracy of the MoCA differs by stroke lateralisation across different cognitive domains. METHODS: We retrospectively examined the cognitive profiles of 228 subacute stroke patients (86 Left, 142 Right), comparing MoCA-total and domain-specific scores with performance on detailed neuropsychological assessment...
February 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28120527/does-diet-mediate-associations-of-volume-and-bouts-of-sedentary-time-with-cardiometabolic-health-indicators-in-adolescents
#7
Elly A Fletcher, Valerie Carson, Sarah A McNaughton, David W Dunstan, Genevieve N Healy, Jo Salmon
OBJECTIVE: Examine the mediating role of diet in the relationship between volume and duration of sedentary time with cardiometabolic health in adolescents. METHODS: Adolescents (12-19 years) participating in the 2003/04 and 2005/06 U.S. National Health and Nutrition Examination Survey (NHANES) were examined. Cardiometabolic health indicators were body mass index z-scores (zBMI) (n = 1,797) and metabolic syndrome (MetS) (n = 812). An ActiGraph hip-worn accelerometer was used to derive total sedentary time and usual sedentary bout duration...
January 25, 2017: Obesity
https://www.readbyqxmd.com/read/28093606/erratum-to-adjusting-foraging-strategies-a-comparison-of-rural-and-urban-common-mynas-acridotheres-tristis
#8
Ira G Federspiel, Alexis Garland, David Guez, Thomas Bugnyar, Susan D Healy, Onur Güntürkün, Andrea S Griffin
No abstract text is available yet for this article.
January 2017: Animal Cognition
https://www.readbyqxmd.com/read/28087821/selection-of-first-line-therapy-in-multiple-sclerosis-using-risk-benefit-decision-analysis
#9
David Bargiela, Matthew T Bianchi, M Brandon Westover, Lori B Chibnik, Brian C Healy, Philip L De Jager, Zongqi Xia
OBJECTIVE: To integrate long-term measures of disease-modifying drug efficacy and risk to guide selection of first-line treatment of multiple sclerosis. METHODS: We created a Markov decision model to evaluate disability worsening and progressive multifocal leukoencephalopathy (PML) risk in patients receiving natalizumab (NTZ), fingolimod (FGL), or glatiramer acetate (GA) over 30 years. Leveraging publicly available data, we integrated treatment utility, disability worsening, and risk of PML into quality-adjusted life-years (QALYs)...
January 13, 2017: Neurology
https://www.readbyqxmd.com/read/28076824/discovery-of-new-nanomolar-inhibitors-of-gpa-extension-of-2-oxo-1-2-dihydropyridinyl-3-yl-amide-based-gpa-inhibitors
#10
Wendy A Loughlin, Ian D Jenkins, N David Karis, Peter C Healy
Glycogen Phosphorylase (GP) is a functionally active dimeric enzyme, which is a target for inhibition of the conversion of glycogen to glucose-1-phosphate. In this study we report the design and synthesis of 14 new pyridone derivatives, and seek to extend the SAR analysis of these compounds. The SAR revealed the minor influence of the amide group, importance of the pyridone ring both spatially around the pyridine ring and for possible π-stacking, and confirmed a preference for inclusion of 3,4-dichlorobenzyl moieties, as bookends to the pyridone scaffold...
December 26, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28063598/burn-injury-influences-the-t-cell-homeostasis-in-a-butyrate-acid-sphingomyelinase-dependent-manner
#11
Teresa C Rice, Stephanie M Armocida, Joshua W Kuethe, Emily F Midura, Ayushi Jain, David A Hildeman, Daniel P Healy, Erich Gulbins, Charles C Caldwell
Following burn injury, a key factor for patients susceptible to opportunistic infections is immune suppression. Butyrate levels are important in maintaining a functional immune system and these levels can be altered after injury. The acid sphingomyelinase (Asm) lipid signaling system has been implicated in a T cell actions with some evidence of being influenced by butyrate. Here, we hypothesized that burn-injury changes in butyrate levels would mediate Asm activity and, consequently, T cell homeostasis. We demonstrate that burn injury temporally decreases butyrate levels...
December 26, 2016: Cellular Immunology
https://www.readbyqxmd.com/read/27941137/tubular-aggregates-and-cylindrical-spirals-have-distinct-immunohistochemical-signatures
#12
Stefen Brady, Estelle G Healy, Qiang Gang, Matt Parton, Ros Quinlivan, Saiju Jacob, Elizabeth Curtis, Safa Al-Sarraj, Caroline A Sewry, Michael G Hanna, Henry Houlden, David Beeson, Janice L Holton
Tubular aggregates and cylindrical spirals are 2 distinct ultrastructural abnormalities observed in muscle biopsies that have similar histochemical staining characteristics on light microscopy. Both are found in a wide range of disorders. Recently, a number of genetic mutations have been reported in conditions with tubular aggregates in skeletal muscle. It is widely accepted that tubular aggregates arise from the sarcoplasmic reticulum, but the origin of cylindrical spirals has been less clearly defined. We describe the histopathological features of myopathies with tubular aggregates, including a detailed immunohistochemical analysis of congenital myasthenic syndromes with tubular aggregates due to mutations in GFPT1 and DPAGT1, and myopathies with cylindrical spirals...
December 2016: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/27884862/associations-of-occupational-standing-with-musculoskeletal-symptoms-a-systematic-review-with-meta-analysis
#13
REVIEW
Pieter Coenen, Lisa Willenberg, Sharon Parry, Joyce W Shi, Lorena Romero, Diana M Blackwood, Christopher G Maher, Genevieve N Healy, David W Dunstan, Leon M Straker
OBJECTIVE: Given the high exposure to occupational standing in specific occupations, and recent initiatives to encourage intermittent standing among white-collar workers, a better understanding of the potential health consequences of occupational standing is required. We aimed to review and quantify the epidemiological evidence on associations of occupational standing with musculoskeletal symptoms. DESIGN: A systematic review was performed. Data from included articles were extracted and described, and meta-analyses conducted when data were sufficiently homogeneous...
November 24, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27849203/erratum-usp15-regulates-type-i-interferon-response-and-is-required-for-pathogenesis-of-neuroinflammation
#14
Sabrina Torre, Maria J Polyak, David Langlais, Nassima Fodil, James M Kennedy, Irena Radovanovic, Joanne Berghout, Gabriel A Leiva-Torres, Connie M Krawczyk, Subburaj Ilangumaran, Karen Mossman, Chen Liang, Klaus-Peter Knobeloch, Luke M Healy, Jack Antel, Nathalie Arbour, Alexandre Prat, Jacek Majewski, Mark Lathrop, Silvia M Vidal, Philippe Gros
No abstract text is available yet for this article.
November 16, 2016: Nature Immunology
https://www.readbyqxmd.com/read/27822056/implementing-interprofessional-bedside-rounding-at-the-prequalification-stage
#15
Daniel R Tuite, David Healy, Thomas S MacKinnon
No abstract text is available yet for this article.
2016: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/27778195/adjusting-foraging-strategies-a-comparison-of-rural-and-urban-common-mynas-acridotheres-tristis
#16
Ira G Federspiel, Alexis Garland, David Guez, Thomas Bugnyar, Susan D Healy, Onur Güntürkün, Andrea S Griffin
Establishment in urbanized environments is associated with changes in physiology, behaviour, and problem-solving. We compared the speed of learning in urban and rural female common mynas, Acridotheres tristis, using a standard visual discrimination task followed by a reversal learning phase. We also examined how quickly each bird progressed through different stages of learning, including sampling and acquisition within both initial and reversal learning, and persistence following reversal. Based on their reliance on very different food resources, we expected urban mynas to learn and reversal learn more quickly but to sample new contingencies for proportionately longer before learning them...
January 2017: Animal Cognition
https://www.readbyqxmd.com/read/27775066/laser-recrystallization-and-inscription-of-compositional-microstructures-in-crystalline-sige-core-fibres
#17
David A Coucheron, Michael Fokine, Nilesh Patil, Dag Werner Breiby, Ole Tore Buset, Noel Healy, Anna C Peacock, Thomas Hawkins, Max Jones, John Ballato, Ursula J Gibson
Glass fibres with silicon cores have emerged as a versatile platform for all-optical processing, sensing and microscale optoelectronic devices. Using SiGe in the core extends the accessible wavelength range and potential optical functionality because the bandgap and optical properties can be tuned by changing the composition. However, silicon and germanium segregate unevenly during non-equilibrium solidification, presenting new fabrication challenges, and requiring detailed studies of the alloy crystallization dynamics in the fibre geometry...
October 24, 2016: Nature Communications
https://www.readbyqxmd.com/read/27749907/safety-and-immunogenicity-of-pfs25-epa-alhydrogel%C3%A2-a-transmission-blocking-vaccine-against-plasmodium-falciparum-an-open-label-study-in-malaria-na%C3%A3-ve-adults
#18
Kawsar R Talaat, Ruth D Ellis, Janet Hurd, Autumn Hentrich, Erin Gabriel, Noreen A Hynes, Kelly M Rausch, Daming Zhu, Olga Muratova, Raul Herrera, Charles Anderson, David Jones, Joan Aebig, Sarah Brockley, Nicholas J MacDonald, Xiaowei Wang, Michael P Fay, Sara A Healy, Anna P Durbin, David L Narum, Yimin Wu, Patrick E Duffy
Transmission-blocking vaccines (TBVs) that target sexual stage parasite development could be an integral part of measures for malaria elimination. Pfs25 is a leading TBV candidate, and previous studies conducted in animals demonstrated an improvement of its functional immunogenicity after conjugation to EPA, a recombinant, detoxified ExoProtein A from Pseudomonas aeruginosa. In this report, we describe results of an open-label, dose-escalating Phase 1 trial to assess the safety and immunogenicity of Pfs25-EPA conjugates formulated with Alhydrogel®...
2016: PloS One
https://www.readbyqxmd.com/read/27749845/genome-wide-association-analyses-identify-new-susceptibility-loci-for-oral-cavity-and-pharyngeal-cancer
#19
Corina Lesseur, Brenda Diergaarde, Andrew F Olshan, Victor Wünsch-Filho, Andrew R Ness, Geoffrey Liu, Martin Lacko, José Eluf-Neto, Silvia Franceschi, Pagona Lagiou, Gary J Macfarlane, Lorenzo Richiardi, Stefania Boccia, Jerry Polesel, Kristina Kjaerheim, David Zaridze, Mattias Johansson, Ana M Menezes, Maria Paula Curado, Max Robinson, Wolfgang Ahrens, Cristina Canova, Ariana Znaor, Xavier Castellsagué, David I Conway, Ivana Holcátová, Dana Mates, Marta Vilensky, Claire M Healy, Neonila Szeszenia-Dąbrowska, Eleonóra Fabiánová, Jolanta Lissowska, Jennifer R Grandis, Mark C Weissler, Eloiza H Tajara, Fabio D Nunes, Marcos B de Carvalho, Steve Thomas, Rayjean J Hung, Wilbert H M Peters, Rolando Herrero, Gabriella Cadoni, H Bas Bueno-de-Mesquita, Annika Steffen, Antonio Agudo, Oxana Shangina, Xiangjun Xiao, Valérie Gaborieau, Amélie Chabrier, Devasena Anantharaman, Paolo Boffetta, Christopher I Amos, James D McKay, Paul Brennan
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34...
December 2016: Nature Genetics
https://www.readbyqxmd.com/read/27736791/the-surface-associated-exopolysaccharide-of-bifidobacterium-longum-35624-plays-an-essential-role-in-dampening-host-proinflammatory-responses-and-repressing-local-th17-responses
#20
Elisa Schiavi, Marita Gleinser, Evelyn Molloy, David Groeger, Remo Frei, Ruth Ferstl, Noelia Rodriguez-Perez, Mario Ziegler, Ray Grant, Thomas Fintan Moriarty, Stephan Plattner, Selena Healy, Mary O'Connell Motherway, Cezmi A Akdis, Jennifer Roper, Friedrich Altmann, Douwe van Sinderen, Liam O'Mahony
: The immune-modulating properties of certain bifidobacterial strains, such as Bifidobacterium longum subsp. longum 35624 (B. longum 35624), have been well described, although the strain-specific molecular characteristics associated with such immune-regulatory activity are not well defined. It has previously been demonstrated that B. longum 35624 produces a cell surface exopolysaccharide (sEPS), and in this study, we investigated the role played by this exopolysaccharide in influencing the host immune response...
December 15, 2016: Applied and Environmental Microbiology
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