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David healy

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https://www.readbyqxmd.com/read/29789663/publisher-correction-a-dhodh-inhibitor-increases-p53-synthesis-and-enhances-tumor-cell-killing-by-p53-degradation-blockage
#1
Marcus J G W Ladds, Ingeborg M M van Leeuwen, Catherine J Drummond, Su Chu, Alan R Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K Sedimbi, Marta Nekulova, Marijke C C Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C A D'Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C Earnshaw, Anna R McCarthy, Nicholas J Westwood, Marie Arsenian-Henriksson, David P Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
The original PDF version of this Article listed the authors as "Marcus J.G.W. Ladds," where it should have read "Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond et al.# ".Also in the PDF version, it was incorrectly stated that "Correspondence and requests for materials should be addressed to S. Lín.", instead of the correct "Correspondence and requests for materials should be addressed to S. Laín."This has been corrected in the PDF version of the Article...
May 22, 2018: Nature Communications
https://www.readbyqxmd.com/read/29769726/microglial-control-of-astrocytes-in-response-to-microbial-metabolites
#2
Veit Rothhammer, Davis M Borucki, Emily C Tjon, Maisa C Takenaka, Chun-Cheih Chao, Alberto Ardura-Fabregat, Kalil Alves de Lima, Cristina Gutiérrez-Vázquez, Patrick Hewson, Ori Staszewski, Manon Blain, Luke Healy, Tradite Neziraj, Matilde Borio, Michael Wheeler, Loic Lionel Dragin, David A Laplaud, Jack Antel, Jorge Ivan Alvarez, Marco Prinz, Francisco J Quintana
Microglia and astrocytes modulate inflammation and neurodegeneration in the central nervous system (CNS)1-3 . Microglia modulate pro-inflammatory and neurotoxic activities in astrocytes, but the mechanisms involved are not completely understood4,5 . Here we report that TGFα and VEGF-B produced by microglia regulate the pathogenic activities of astrocytes in the experimental autoimmune encephalomyelitis (EAE) mouse model of multiple sclerosis. Microglia-derived TGFα acts via the ErbB1 receptor in astrocytes to limit their pathogenic activities and EAE development...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29733031/citizen-petition-sexual-side-effects-of-ssris-and-snris
#3
David Healy
No abstract text is available yet for this article.
May 1, 2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29733030/enduring-sexual-dysfunction-after-treatment-with-antidepressants-5%C3%AE-reductase-inhibitors-and-isotretinoin-300-cases
#4
David Healy, Joanna Le Noury, Derelie Mangin
OBJECTIVE: To investigate clinical reports of post-SSRI sexual dysfunction (PSSD), post-finasteride syndrome (PFS) and enduring sexual dysfunction following isotretinoin. METHODS: Data from RxISK.org, a global adverse event reporting website, have been used to establish the clinical features, demographic details and clinical trajectories of syndromes of persistent sexual difficulties following three superficially different treatment modalities.RESULTSWe report on 300 cases of enduring sexual dysfunction from 37 countries following 14 different drugs comprised of serotonin reuptake inhibiting antidepressants, 5α-reductase inhibitors and isotretinoin...
May 1, 2018: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/29726906/associations-of-sedentary-time-and-diabetes-in-6166-older-women-the-objective-physical-activity-and-cardiovascular-health-study
#5
John Bellettiere, Genevieve N Healy, Michael J LaMonte, Jacqueline Kerr, Kelly R Evenson, Eileen Rillamas-Sun, Chongzhi Di, David M Buchner, Melbourne F Hovell, Andrea Z LaCroix
Background: We examined associations of sedentary time and sedentary accumulation patterns (i.e., how sedentary time is accumulated) with prevalent diabetes in an ethnically diverse cohort of older women. Methods: Community-dwelling women aged 63-99 (n=6,116; median age=79) wore ActiGraph GT3X+ accelerometers 24 hours/day for up to seven days from which we derived average daily sedentary time and three measures of sedentary accumulation patterns: breaks in sedentary time, usual sedentary bout duration, and alpha...
May 3, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29703821/a-rationally-designed-fully-human-egfrviii-cd3-targeted-bispecific-antibody-redirects-human-t-cells-to-treat-patient-derived-intracerebral-malignant-glioma
#6
Patrick C Gedeon, Teilo H Schaller, Satish K Chitneni, Bryan D Choi, Chien-Tsun Kuan, Carter M Suryadevara, David J Snyder, Robert J Schmittling, Scott E Szafranski, Xiuyu Cui, Patrick Healy, James E Herndon, Roger E McLendon, Stephen T Keir, Gary E Archer, Elizabeth Reap, Luis Sanchez-Perez, Darell D Bigner, John H Sampson
PURPOSE: Conventional therapy for malignant glioma (MG) fails to specifically target tumor cells. In contrast, substantial evidence indicates that if appropriately redirected, T cells can precisely eradicate tumors. Here we report the rational development of a fully-human bispecific antibody (hEGFRvIII-CD3 bi-scFv) that redirects human T cells to lyse MG expressing a tumor-specific mutation of the epidermal growth factor receptor (EGFRvIII). EXPERIMENTAL DESIGN: We generated a panel of bispecific single-chain variable-fragments and optimized design through successive rounds of screening and refinement...
April 27, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29667326/total-glossolaryngectomy-cohort-study-n-25-survival-function-and-quality-of-life
#7
Yasmine Kamhieh, Hannah Fox, Sarah Healy, Emma Hallett, Stuart Quine, David Owens, Alun Tomkinson, Cellan Thomas, David Smith, Duncan Ingrams, Carl Passant, Laysan Pope, Connor Marnane, Sandeep Berry
Glossolaryngectomy is a major operation with significant biopsychosocial implications. Outcome data in the literature is limited. This study reports the overall survival rate (68% at 1 year) and functional outcomes. Despite the significant psychological impact of the lack of speech, all interviewed patients were glad they had had the operation. We argue based on these results that glossolaryngectomy remains an important option for certain motivated patients with limited treatment alternatives. This article is protected by copyright...
April 18, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29665620/personalized-cardio-metabolic-responses-to-an-anti-inflammatory-nutrition-intervention-in-obese-adolescents-a-randomized-controlled-crossover-trial
#8
Aoibheann M McMorrow, Ruth M Connaughton, Tiago R Magalhães, Fiona C McGillicuddy, Maria F Hughes, David Cheishvili, Melissa J Morine, Sean Ennis, Marie-Louise Healy, Edna F Roche, Richard E Tremblay, Moshe Szyf, Fiona E Lithander, Helen M Roche
SCOPE: Chronic inflammation and hypoadiponectinemia are characteristic of obesity-induced insulin resistance (IR). The effect of an anti-inflammatory nutrition supplement (AINS) on IR and adiponectin biology in overweight adolescents was investigated. The secondary objective was to examine the extent to which individuals' biomarker profiles, derived from baseline phenotypes, predicted response or not to the AINS. Additionally, the impact of DNA methylation on intervention efficacy was assessed...
April 17, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29549331/a-dhodh-inhibitor-increases-p53-synthesis-and-enhances-tumor-cell-killing-by-p53-degradation-blockage
#9
Marcus J G W Ladds, Ingeborg M M van Leeuwen, Catherine J Drummond, Su Chu, Alan R Healy, Gergana Popova, Andrés Pastor Fernández, Tanzina Mollick, Suhas Darekar, Saikiran K Sedimbi, Marta Nekulova, Marijke C C Sachweh, Johanna Campbell, Maureen Higgins, Chloe Tuck, Mihaela Popa, Mireia Mayoral Safont, Pascal Gelebart, Zinayida Fandalyuk, Alastair M Thompson, Richard Svensson, Anna-Lena Gustavsson, Lars Johansson, Katarina Färnegårdh, Ulrika Yngve, Aljona Saleh, Martin Haraldsson, Agathe C A D'Hollander, Marcela Franco, Yan Zhao, Maria Håkansson, Björn Walse, Karin Larsson, Emma M Peat, Vicent Pelechano, John Lunec, Borivoj Vojtesek, Mar Carmena, William C Earnshaw, Anna R McCarthy, Nicholas J Westwood, Marie Arsenian-Henriksson, David P Lane, Ravi Bhatia, Emmet McCormack, Sonia Laín
The development of non-genotoxic therapies that activate wild-type p53 in tumors is of great interest since the discovery of p53 as a tumor suppressor. Here we report the identification of over 100 small-molecules activating p53 in cells. We elucidate the mechanism of action of a chiral tetrahydroindazole (HZ00), and through target deconvolution, we deduce that its active enantiomer (R)-HZ00, inhibits dihydroorotate dehydrogenase (DHODH). The chiral specificity of HZ05, a more potent analog, is revealed by the crystal structure of the (R)-HZ05/DHODH complex...
March 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29540730/genetic-contributions-to-the-association-between-adult-height-and-head-and-neck-cancer-a-mendelian-randomization-analysis
#10
Roberta Pastorino, Anna Puggina, Robert Carreras-Torres, Pagona Lagiou, Ivana Holcátová, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsagué, Tatiana V Macfarlane, Luigi Barzan, Cristina Canova, Nalin S Thakker, David I Conway, Ariana Znaor, Claire M Healy, Wolfgang Ahrens, David Zaridze, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Eleonora Fabianova, Ioan Nicolae Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Paul Brennan, Valérie Gaborieau, James D McKay, Stefania Boccia
With the aim to dissect the effect of adult height on head and neck cancer (HNC), we use the Mendelian randomization (MR) approach to test the association between genetic instruments for height and the risk of HNC. 599 single nucleotide polymorphisms (SNPs) were identified as genetic instruments for height, accounting for 16% of the phenotypic variation. Genetic data concerning HNC cases and controls were obtained from a genome-wide association study. Summary statistics for genetic association were used in complementary MR approaches: the weighted genetic risk score (GRS) and the inverse-variance weighted (IVW)...
March 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29484541/taking-an-insect-inspired-approach-to-bird-navigation
#11
REVIEW
David J Pritchard, Susan D Healy
Navigation is an essential skill for many animals, and understanding how animal use environmental information, particularly visual information, to navigate has a long history in both ethology and psychology. In birds, the dominant approach for investigating navigation at small-scales comes from comparative psychology, which emphasizes the cognitive representations underpinning spatial memory. The majority of this work is based in the laboratory and it is unclear whether this context itself affects the information that birds learn and use when they search for a location...
March 2018: Learning & Behavior
https://www.readbyqxmd.com/read/29483032/vaccination-coverage-among-foreign-born-and-u-s-born-adolescents-in-the-united-states-successes-and-gaps-national-immunization-survey-teen-2012-2014
#12
Jessica Healy, Alfonso Rodriguez-Lainz, Laurie D Elam-Evans, Holly A Hill, Sarah Reagan-Steiner, David Yankey
BACKGROUND: An overall increase has been reported in vaccination rates among adolescents during the past decade. Studies of vaccination coverage have shown disparities when comparing foreign-born and U.S.-born populations among children and adults; however, limited information is available concerning potential disparities in adolescents. METHODS: The National Immunization Survey-Teen is a random-digit-dialed telephone survey of caregivers of adolescents aged 13-17 years, followed by a mail survey to vaccination providers that is used to estimate vaccination coverage among the U...
March 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29467182/somatic-il4r-mutations-in-primary-mediastinal-large-b-cell-lymphoma-lead-to-constitutive-jak-stat-signaling-activation
#13
Elena Viganò, Jay Gunawardana, Anja Mottok, Tessa Van Tol, Katina Mak, Fong Chun Chan, Lauren Chong, Elizabeth Chavez, Bruce Woolcock, Katsuyoshi Takata, David Twa, Hennady P Shulha, Adèle Telenius, Olga Kutovaya, Stacy S Hung, Shannon Healy, Susana Ben-Neriah, Karen Leroy, Philippe Gaulard, Arjan Diepstra, Robert Kridel, Kerry J Savage, Lisa Rimsza, Randy Gascoyne, Christian Steidl
Primary mediastinal large B-cell lymphoma (PMBCL) is a distinct subtype of diffuse large B-cell lymphoma thought to arise from thymic medullary B cells. Gene mutations underlying the molecular pathogenesis of the disease are incompletely characterized. Here, we describe novel somatic IL4R mutations in 15 of 62 primary cases of PMBCL (24.2%) and in all PMBCL-derived cell lines tested. The majority of mutations (11/21; 52%) were hotspot single nucleotide variants in exon 8, leading to an I242N amino acid change in the transmembrane domain...
May 3, 2018: Blood
https://www.readbyqxmd.com/read/29405297/the-influence-of-smoking-age-and-stage-at-diagnosis-on-the-survival-after-larynx-hypopharynx-and-oral-cavity-cancers-in-europe-the-arcage-study
#14
Renata Abrahão, Devasena Anantharaman, Valérie Gaborieau, Behnoush Abedi-Ardekani, Pagona Lagiou, Areti Lagiou, Wolfgang Ahrens, Ivana Holcatova, Jaroslav Betka, Franco Merletti, Lorenzo Richiardi, Kristina Kjaerheim, Diego Serraino, Jerry Polesel, Lorenzo Simonato, Laia Alemany, Antonio Agudo Trigueros, Tatiana V Macfarlane, Gary J Macfarlane, Ariana Znaor, Max Robinson, Cristina Canova, David I Conway, Sylvia Wright, Claire M Healy, Mary Toner, Gabriella Cadoni, Stefania Boccia, Tarik Gheit, Massimo Tommasino, Ghislaine Scelo, Paul Brennan
Head and neck cancer (HNC) is a preventable malignancy that continues to cause substantial morbidity and mortality worldwide. Using data from the ARCAGE and Rome studies, we investigated the main predictors of survival after larynx, hypopharynx and oral cavity (OC) cancers. We used the Kaplan-Meier method to estimate overall survival, and Cox proportional models to examine the relationship between survival and sociodemographic and clinical characteristics. 604 larynx, 146 hypopharynx and 460 OC cancer cases were included in this study...
February 6, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29377117/vs2drti-simulating-heat-and-reactive-solute-transport-in-variably-saturated-porous-media
#15
Richard W Healy, Sosina S Haile, David L Parkhurst, Scott R Charlton
Variably saturated groundwater flow, heat transport, and solute transport are important processes in environmental phenomena, such as the natural evolution of water chemistry of aquifers and streams, the storage of radioactive waste in a geologic repository, the contamination of water resources from acid-rock drainage, and the geologic sequestration of carbon dioxide. Up to now, our ability to simulate these processes simultaneously with fully coupled reactive transport models has been limited to complex and often difficult-to-use models...
January 29, 2018: Ground Water
https://www.readbyqxmd.com/read/29309546/inclusion-of-the-mesentery-in-ileocolic-resection-for-crohn-s-disease-is-associated-with-reduced-surgical-recurrence
#16
J Calvin Coffey, Miranda G Kiernan, Shaheel M Sahebally, Awad Jarrar, John P Burke, Patrick A Kiely, Bo Shen, David Waldron, Colin Peirce, Manus Moloney, Maeve Skelly, Paul Tibbitts, Hena Hidayat, Peter N Faul, Vourneen Healy, D Peter O Leary, Leon G Walsh, Peter Dockery, P Ronan O Connell, Sean Martin, Fergus Shanahan, Claudio Fiocchi, Colum Dunne
Background and Aims: Inclusion of the mesentery during resection for colorectal cancer is associated with improved outcomes but has yet to be evaluated in Crohn's disease. This study aimed to determine the rate of surgical recurrence after inclusion of mesentery during ileocolic resection for Crohn's disease. Methods: Surgical recurrence rates were compared between two cohorts. Cohort A (n=30) underwent conventional ileocolic resection where the mesentery was divided flush with the intestine...
January 4, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29241701/production-of-cocrystals-in-an-excipient-matrix-by-spray-drying
#17
David Walsh, Dolores R Serrano, Zelalem Ayenew Worku, Brid A Norris, Anne Marie Healy
Spray drying is a well-established scale-up technique for the production of cocrystals. However, to the best of our knowledge, the effect of introducing a third component into the feed solution during the spray drying process has never been investigated. Cocrystal formation in the presence of a third component by a one-step spray drying process has the potential to reduce the number of unit operations which are required to produce a final pharmaceutical product (e.g. by eliminating blending with excipient)...
January 30, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29210997/tempol-supplementation-restores-diaphragm-force-and-metabolic-enzyme-activities-in-mdx-mice
#18
David P Burns, Izza Ali, Clement Rieux, James Healy, Greg Jasionek, Ken D O'Halloran
Duchenne muscular dystrophy (DMD) is characterized by striated muscle weakness, cardiomyopathy, and respiratory failure. Since oxidative stress is recognized as a secondary pathology in DMD, the efficacy of antioxidant intervention, using the superoxide scavenger tempol, was examined on functional and biochemical status of dystrophin-deficient diaphragm muscle. Diaphragm muscle function was assessed, ex vivo, in adult male wild-type and dystrophin-deficient mdx mice, with and without a 14-day antioxidant intervention...
December 6, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29196273/optimising-the-in-vitro-and-in-vivo-performance-of-oral-cocrystal-formulations-via-spray-coating
#19
Dolores R Serrano, David Walsh, Peter O'Connell, Naila A Mugheirbi, Zelalem Ayenew Worku, Francisco Bolas-Fernandez, Carolina Galiana, Maria Auxiliadora Dea-Ayuela, Anne Marie Healy
Engineering of pharmaceutical cocrystals is an advantageous alternative to salt formation for improving the aqueous solubility of hydrophobic drugs. Although, spray drying is a well-established scale-up technique in the production of cocrystals, several issues can arise such as sublimation or stickiness due to low glass transition temperatures of some organic molecules, making the process very challenging. Even though, fluidised bed spray coating has been successfully employed in the production of amorphous drug-coated particles, to the best of our knowledge, it has never been employed in the production of cocrystals...
March 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29166319/cardiometabolic-impact-of-changing-sitting-standing-and-stepping-in-the-workplace
#20
Elisabeth A H Winkler, Sebastien Chastin, Elizabeth G Eakin, Neville Owen, Anthony D Lamontagne, Marj Moodie, Paddy C Dempsey, Bronwyn A Kingwell, David W Dunstan, Genevieve N Healy
BACKGROUND: According to cross-sectional and acute experimental evidence, reducing sitting time should improve cardiometabolic health risk biomarkers. Furthermore, the improvements obtained may depend on whether sitting is replaced with standing or ambulatory activities. Based on data from the Stand Up Victoria multicomponent workplace intervention, we examined this issue using compositional data analysis-a method that can examine and compare all activity changes simultaneously. METHODS: Participants receiving the intervention (n = 136 ≥ 0...
March 2018: Medicine and Science in Sports and Exercise
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