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David healy

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https://www.readbyqxmd.com/read/27884862/associations-of-occupational-standing-with-musculoskeletal-symptoms-a-systematic-review-with-meta-analysis
#1
REVIEW
Pieter Coenen, Lisa Willenberg, Sharon Parry, Joyce W Shi, Lorena Romero, Diana M Blackwood, Christopher G Maher, Genevieve N Healy, David W Dunstan, Leon M Straker
OBJECTIVE: Given the high exposure to occupational standing in specific occupations, and recent initiatives to encourage intermittent standing among white-collar workers, a better understanding of the potential health consequences of occupational standing is required. We aimed to review and quantify the epidemiological evidence on associations of occupational standing with musculoskeletal symptoms. DESIGN: A systematic review was performed. Data from included articles were extracted and described, and meta-analyses conducted when data were sufficiently homogeneous...
November 24, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27849203/erratum-usp15-regulates-type-i-interferon-response-and-is-required-for-pathogenesis-of-neuroinflammation
#2
Sabrina Torre, Maria J Polyak, David Langlais, Nassima Fodil, James M Kennedy, Irena Radovanovic, Joanne Berghout, Gabriel A Leiva-Torres, Connie M Krawczyk, Subburaj Ilangumaran, Karen Mossman, Chen Liang, Klaus-Peter Knobeloch, Luke M Healy, Jack Antel, Nathalie Arbour, Alexandre Prat, Jacek Majewski, Mark Lathrop, Silvia M Vidal, Philippe Gros
No abstract text is available yet for this article.
November 16, 2016: Nature Immunology
https://www.readbyqxmd.com/read/27822056/implementing-interprofessional-bedside-rounding-at-the-prequalification-stage
#3
Daniel R Tuite, David Healy, Thomas S MacKinnon
No abstract text is available yet for this article.
2016: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/27778195/adjusting-foraging-strategies-a-comparison-of-rural-and-urban-common-mynas-acridotheres-tristis
#4
Ira G Federspiel, Alexis Garland, David Guez, Thomas Bugynar, Susan D Healy, Onur Güntürkün, Andrea S Griffin
Establishment in urbanized environments is associated with changes in physiology, behaviour, and problem-solving. We compared the speed of learning in urban and rural female common mynas, Acridotheres tristis, using a standard visual discrimination task followed by a reversal learning phase. We also examined how quickly each bird progressed through different stages of learning, including sampling and acquisition within both initial and reversal learning, and persistence following reversal. Based on their reliance on very different food resources, we expected urban mynas to learn and reversal learn more quickly but to sample new contingencies for proportionately longer before learning them...
October 24, 2016: Animal Cognition
https://www.readbyqxmd.com/read/27775066/laser-recrystallization-and-inscription-of-compositional-microstructures-in-crystalline-sige-core-fibres
#5
David A Coucheron, Michael Fokine, Nilesh Patil, Dag Werner Breiby, Ole Tore Buset, Noel Healy, Anna C Peacock, Thomas Hawkins, Max Jones, John Ballato, Ursula J Gibson
Glass fibres with silicon cores have emerged as a versatile platform for all-optical processing, sensing and microscale optoelectronic devices. Using SiGe in the core extends the accessible wavelength range and potential optical functionality because the bandgap and optical properties can be tuned by changing the composition. However, silicon and germanium segregate unevenly during non-equilibrium solidification, presenting new fabrication challenges, and requiring detailed studies of the alloy crystallization dynamics in the fibre geometry...
October 24, 2016: Nature Communications
https://www.readbyqxmd.com/read/27749907/safety-and-immunogenicity-of-pfs25-epa-alhydrogel%C3%A2-a-transmission-blocking-vaccine-against-plasmodium-falciparum-an-open-label-study-in-malaria-na%C3%A3-ve-adults
#6
Kawsar R Talaat, Ruth D Ellis, Janet Hurd, Autumn Hentrich, Erin Gabriel, Noreen A Hynes, Kelly M Rausch, Daming Zhu, Olga Muratova, Raul Herrera, Charles Anderson, David Jones, Joan Aebig, Sarah Brockley, Nicholas J MacDonald, Xiaowei Wang, Michael P Fay, Sara A Healy, Anna P Durbin, David L Narum, Yimin Wu, Patrick E Duffy
Transmission-blocking vaccines (TBVs) that target sexual stage parasite development could be an integral part of measures for malaria elimination. Pfs25 is a leading TBV candidate, and previous studies conducted in animals demonstrated an improvement of its functional immunogenicity after conjugation to EPA, a recombinant, detoxified ExoProtein A from Pseudomonas aeruginosa. In this report, we describe results of an open-label, dose-escalating Phase 1 trial to assess the safety and immunogenicity of Pfs25-EPA conjugates formulated with Alhydrogel®...
2016: PloS One
https://www.readbyqxmd.com/read/27749845/genome-wide-association-analyses-identify-new-susceptibility-loci-for-oral-cavity-and-pharyngeal-cancer
#7
Corina Lesseur, Brenda Diergaarde, Andrew F Olshan, Victor Wünsch-Filho, Andrew R Ness, Geoffrey Liu, Martin Lacko, José Eluf-Neto, Silvia Franceschi, Pagona Lagiou, Gary J Macfarlane, Lorenzo Richiardi, Stefania Boccia, Jerry Polesel, Kristina Kjaerheim, David Zaridze, Mattias Johansson, Ana M Menezes, Maria Paula Curado, Max Robinson, Wolfgang Ahrens, Cristina Canova, Ariana Znaor, Xavier Castellsagué, David I Conway, Ivana Holcátová, Dana Mates, Marta Vilensky, Claire M Healy, Neonila Szeszenia-Dąbrowska, Eleonóra Fabiánová, Jolanta Lissowska, Jennifer R Grandis, Mark C Weissler, Eloiza H Tajara, Fabio D Nunes, Marcos B de Carvalho, Steve Thomas, Rayjean J Hung, Wilbert H M Peters, Rolando Herrero, Gabriella Cadoni, H Bas Bueno-de-Mesquita, Annika Steffen, Antonio Agudo, Oxana Shangina, Xiangjun Xiao, Valérie Gaborieau, Amélie Chabrier, Devasena Anantharaman, Paolo Boffetta, Christopher I Amos, James D McKay, Paul Brennan
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34...
December 2016: Nature Genetics
https://www.readbyqxmd.com/read/27736791/the-surface-associated-exopolysaccharide-of-bifidobacterium-longum-35624-plays-an-essential-role-in-dampening-host-proinflammatory-responses-and-repressing-local-th17-responses
#8
Elisa Schiavi, Marita Gleinser, Evelyn Molloy, David Groeger, Remo Frei, Ruth Ferstl, Noelia Rodriguez-Perez, Mario Ziegler, Ray Grant, Thomas Fintan Moriarty, Stephan Plattner, Selena Healy, Mary O'Connell Motherway, Cezmi A Akdis, Jennifer Roper, Friedrich Altmann, Douwe van Sinderen, Liam O'Mahony
: The immune-modulating properties of certain bifidobacterial strains, such as Bifidobacterium longum subsp. longum 35624 (B. longum 35624), have been well described, although the strain-specific molecular characteristics associated with such immune-regulatory activity are not well defined. It has previously been demonstrated that B. longum 35624 produces a cell surface exopolysaccharide (sEPS), and in this study, we investigated the role played by this exopolysaccharide in influencing the host immune response...
December 15, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27721430/usp15-regulates-type-i-interferon-response-and-is-required-for-pathogenesis-of-neuroinflammation
#9
Sabrina Torre, Maria J Polyak, David Langlais, Nassima Fodil, James M Kennedy, Irena Radovanovic, Joanne Berghout, Gabriel A Leiva-Torres, Connie M Krawczyk, Subburaj Ilangumaran, Karen Mossman, Chen Liang, Klaus-Peter Knobeloch, Luke M Healy, Jack Antel, Nathalie Arbour, Alexandre Prat, Jacek Majewski, Mark Lathrop, Silvia M Vidal, Philippe Gros
Genes and pathways in which inactivation dampens tissue inflammation present new opportunities for understanding the pathogenesis of common human inflammatory diseases, including inflammatory bowel disease, rheumatoid arthritis and multiple sclerosis. We identified a mutation in the gene encoding the deubiquitination enzyme USP15 (Usp15(L749R)) that protected mice against both experimental cerebral malaria (ECM) induced by Plasmodium berghei and experimental autoimmune encephalomyelitis (EAE). Combining immunophenotyping and RNA sequencing in brain (ECM) and spinal cord (EAE) revealed that Usp15(L749R)-associated resistance to neuroinflammation was linked to dampened type I interferon responses in situ...
October 10, 2016: Nature Immunology
https://www.readbyqxmd.com/read/27720115/a-review-of-oxyhalide-disinfection-by-products-determination-in-water-by-ion-chromatography-and-ion-chromatography-mass-spectrometry
#10
Elizabeth S Gilchrist, David A Healy, Virginia N Morris, Jeremy D Glennon
This paper is a review of ion chromatographic (IC) separations of inorganic oxyhalide disinfection by-products (DBPs) in water and beverages. The review outlines the chemical mechanisms of formation, regulation of maximum allowable levels, chromatographic column selection and speciation. In addition, this review highlights the application of IC coupled to mass spectrometry (MS) for trace and elemental composition analysis of oxyhalides, along with the analytical considerations associated to enable sensitive analysis...
October 26, 2016: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27685130/method-and-phantom-to-study-combined-effects-of-in-plane-x-y-and-z-axis-resolution-for-3d-ct-imaging
#11
David Goodenough, Josh Levy, Smari Kristinsson, Jesper Fredriksson, Hildur Olafsdottir, Austin Healy
Increasingly, the advent of multislice CT scanners, volume CT scanners, and total body spiral acquisition modes has led to the use of Multi Planar Reconstruction and 3D datasets. In considering 3D resolution properties of a CT system it is important to note that both the in-plane (x,y) and z-axis (slice thickness) influence the visual-ization and detection of objects within the scanned volume. This study investigates ways to consider both the in-plane resolution and the z-axis resolution in a single phantom wherein analytic or visualized analysis can yield information on these combined effects...
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27662279/study-329-continuation-phase-safety-and-efficacy-of-paroxetine-and-imipramine-in-extended-treatment-of-adolescent-major-depression
#12
Joanna Le Noury, John M Nardo, David Healy, Jon Jureidini, Melissa Raven, Catalin Tufanaru, Elia Abi-Jaoude
OBJECTIVE: This is an analysis of the unpublished continuation phase of Study 329, the primary objective of which was to compare the efficacy and safety of paroxetine and imipramine with placebo in the treatment of adolescents with unipolar major depression. The objectives of the continuation phase were to assess safety and relapse rates in the longer term. The objective of this publication, under the Restoring Invisible and Abandoned Trials (RIAT) initiative, was to see whether access to and analysis of the previously unpublished dataset from the continuation phase of this randomized controlled trial would have clinically relevant implications for evidence-based medicine...
September 17, 2016: International Journal of Risk & Safety in Medicine
https://www.readbyqxmd.com/read/27633624/the-individual-social-and-environmental-correlates-of-physical-activity-and-screen-time-in-irish-children-growing-up-in-ireland-study
#13
Jeanette M Garcia, Sean Healy, David Rice
BACKGROUND: The aim of this study was to use a social-ecological approach to examine the influence of individual, social, and environmental factors on moderate-to-vigorous physical activity (MVPA) and screen-time in a sample of nine year old children in Ireland. METHODS: The sample was 1509 boys and girls from the Growing Up in Ireland (GUI) national study. MVPA, screen time, and individual, social, and environmental variables were assessed via questionnaires completed by children, their parents, and their teachers...
August 24, 2016: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/27623134/omip-036-co-inhibitory-receptor-immune-checkpoint-expression-analysis-in-human-t-cell-subsets
#14
Zachary R Healy, David M Murdoch
No abstract text is available yet for this article.
October 2016: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/27595754/feasibility-and-acceptability-of-reducing-workplace-sitting-time-a-qualitative-study-with-australian-office-workers
#15
Nyssa T Hadgraft, Charlotte L Brakenridge, Anthony D LaMontagne, Brianna S Fjeldsoe, Brigid M Lynch, David W Dunstan, Neville Owen, Genevieve N Healy, Sheleigh P Lawler
BACKGROUND: Office workers spend a large proportion of their working hours sitting. This may contribute to an increased risk of chronic disease and premature mortality. While there is growing interest in workplace interventions targeting prolonged sitting, few qualitative studies have explored workers' perceptions of reducing occupational sitting outside of an intervention context. This study explored barriers to reducing office workplace sitting, and the feasibility and acceptability of strategies targeting prolonged sitting in this context...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27594680/rare-variants-in-sqstm1-and-vcp-genes-and-risk-of-sporadic-inclusion-body-myositis
#16
Qiang Gang, Conceição Bettencourt, Pedro M Machado, Stefen Brady, Janice L Holton, Alan M Pittman, Deborah Hughes, Estelle Healy, Matthew Parton, David Hilton-Jones, Perry B Shieh, Merrilee Needham, Christina Liang, Edmar Zanoteli, Leonardo Valente de Camargo, Boel De Paepe, Jan De Bleecker, Aziz Shaibani, Michela Ripolone, Raffaella Violano, Maurizio Moggio, Richard J Barohn, Mazen M Dimachkie, Marina Mora, Renato Mantegazza, Simona Zanotti, Andrew B Singleton, Michael G Hanna, Henry Houlden
Genetic factors have been suggested to be involved in the pathogenesis of sporadic inclusion body myositis (sIBM). Sequestosome 1 (SQSTM1) and valosin-containing protein (VCP) are 2 key genes associated with several neurodegenerative disorders but have yet to be thoroughly investigated in sIBM. A candidate gene analysis was conducted using whole-exome sequencing data from 181 sIBM patients, and whole-transcriptome expression analysis was performed in patients with genetic variants of interest. We identified 6 rare missense variants in the SQSTM1 and VCP in 7 sIBM patients (4...
August 8, 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/27582069/characterisation-of-corglaes-%C3%A2-pure-107-fibres-for-biomedical-applications
#17
Ross Colquhoun, Nikolaj Gadegaard, David M Healy, K Elizabeth Tanner
A degradable ultraphosphate (55 mol % P2O5) quinternary phosphate glass composition has been characterised in terms of its chemical, mechanical and degradation properties both as a bulk material and after drawing into fibres. This glass formulation displayed a large processing window simplifying fibre drawing. The fibres displayed stiffness and strength of 65.5 ± 20.8 GPa and 426±143 MPa. While amorphous discs of the glass displayed a linear dissolution rate of 0.004 mg cm(-2) h(-1) at 37 °C, in a static solution with a reduction in media pH...
October 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27526175/a-cluster-randomized-controlled-trial-to-reduce-office-workers-sitting-time-effect-on-activity-outcomes
#18
Genevieve N Healy, Elizabeth G Eakin, Neville Owen, Anthony D Lamontagne, Marj Moodie, Elisabeth A H Winkler, Brianna S Fjeldsoe, Glen Wiesner, Lisa Willenberg, David W Dunstan
PURPOSE: This study aimed to evaluate the initial and long-term effectiveness of a workplace intervention compared with usual practice, targeting the reduction of sitting on activity outcomes. METHODS: Office worksites (≥1 km apart) from a single organization in Victoria, Australia, were cluster randomized to intervention (n = 7) or control (n = 7). Participants were 231 desk-based office workers (5-39 participants per worksite) working at least 0.6 full-time equivalent...
September 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27483124/success-of-intubation-rescue-techniques-after-failed-direct-laryngoscopy-in-adults-a-retrospective-comparative-analysis-from-the-multicenter-perioperative-outcomes-group
#19
Michael F Aziz, Ansgar M Brambrink, David W Healy, Amy Wen Willett, Amy Shanks, Tyler Tremper, Leslie Jameson, Jacqueline Ragheb, Daniel A Biggs, William C Paganelli, Janavi Rao, Jerry L Epps, Douglas A Colquhoun, Patrick Bakke, Sachin Kheterpal
BACKGROUND: Multiple attempts at tracheal intubation are associated with mortality, and successful rescue requires a structured plan. However, there remains a paucity of data to guide the choice of intubation rescue technique after failed initial direct laryngoscopy. The authors studied a large perioperative database to determine success rates for commonly used intubation rescue techniques. METHODS: Using a retrospective, observational, comparative design, the authors analyzed records from seven academic centers within the Multicenter Perioperative Outcomes Group between 2004 and 2013...
October 2016: Anesthesiology
https://www.readbyqxmd.com/read/27454014/dark-adaptation-at-high-altitude-an-unexpected-pupillary-response-to-chronic-hypoxia-in-andean-highlanders
#20
Katherine Healy, Alain B Labrique, J Jaime Miranda, Robert H Gilman, David Danz, Victor G Davila-Roman, Luis Huicho, Fabiola León-Velarde, William Checkley
Healy, Katherine, Alain B. Labrique, J. Jaime Miranda, Robert H. Gilman, David Danz, Victor G. Davila-Roman, Luis Huicho, Fabiola León-Velarde, and William Checkley. Dark adaptation at high altitude: an unexpected pupillary response to chronic hypoxia in Andean highlanders. High Alt Med Biol. 16:000-000, 2016.-Chronic mountain sickness is a maladaptive response to high altitude (>2500 m above sea level) and is characterized by excessive erythrocytosis and hypoxemia resulting from long-term hypobaric hypoxia...
July 25, 2016: High Altitude Medicine & Biology
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