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asimina triloba

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https://www.readbyqxmd.com/read/27864266/unusual-twig-twistiness-in-pawpaw-asimina-triloba-provides-biomechanical-protection-for-distal-foliage-in-high-winds
#1
Katherine R Goodrich, Luis A Ortiz, David J Coughlin
PREMISE OF STUDY: Deciduous woody species invest considerable resources in the growth of new foliage and distal stems. This new growth is at risk for mechanical damage from high winds and storms. Pawpaw has large leaves borne distally on thin twigs. Following a storm, pawpaw branches sometimes exhibit a persistent "flipped" orientation, slowly returning upright over 24 h. We investigated biomechanical properties of pawpaw twigs, comparing them to co-occurring species with similarly high leaf areas and loads, which do not exhibit this "flipping"...
November 18, 2016: American Journal of Botany
https://www.readbyqxmd.com/read/27199902/spatial-and-temporal-profiling-of-griseofulvin-production-in-xylaria-cubensis-using-mass-spectrometry-mapping
#2
Vincent P Sica, Evan R Rees, Edem Tchegnon, Robert H Bardsley, Huzefa A Raja, Nicholas H Oberlies
A large portion of natural products research revolves around the discovery of new, bioactive chemical entities; however, studies to probe the biological purpose of such secondary metabolites for the host organism are often limited. Mass spectrometry mapping of secondary metabolite biosynthesis in situ can be used to probe a series of ecological questions about fungi that may be lost through traditional natural products chemistry extraction protocols. A griseofulvin-producing fungal culture of the Xylariaceae family, isolated as an endophyte of the tree Asimina triloba, was analyzed through a series of spatial and temporal mapping experiments...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/26444335/method-development-for-quantification-of-the-environmental-neurotoxin-annonacin-in-rat-plasma-by-uplc-ms-ms-and-application-to-a-pharmacokinetic-study
#3
Natacha Bonneau, Isabelle Schmitz-Afonso, Alain Brunelle, David Touboul, Pierre Champy
Annonacin is an environmental neurotoxin identified in the pulp of several fruits of the Annonaceae family (for example in Annona muricata, Asimina triloba), whose consumption was linked with the occurrence of sporadic atypical Parkinsonism with dementia. Pharmacokinetic parameters of this molecule are unknown. A method for its quantification in Rat plasma was developed, using its analogue annonacinone as an internal standard. Extraction from plasma was performed using ethylacetate with a good recovery. Quantification was performed by UPLC-MS/MS in SRM mode, based on the loss of the γ-methyl-γ-lactone (-112amu) from the sodium-cationized species [M+Na](+) of both annonacin and internal standard...
November 1, 2015: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/25594104/determination-of-neurotoxic-acetogenins-in-pawpaw-asimina-triloba-fruit-by-lc-hrms
#4
Robert A Levine, Kristy M Richards, Kevin Tran, Rensheng Luo, Andreq Thomas, Robert E Smith
The concentrations of the neurotoxins, annonacin and squamocin, were determined in a lyophilized sample of the fruit pulp of the North American pawpaw (Asimina triloba) by LC coupled to high resolution mass spectrometry, or LC-HRMS. The sample was extracted using dry methanol at 100 oC and 10 MPascal pressure in a sealed container. More annonacin and squamocin (7.72 and 0.162 mg/g, respectively) were solubilized at 100 oC than 23 or 60 oC. Also, several isomers of annonacin and squamocin were separated and detected, but not quantified...
January 16, 2015: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/25172760/phytochemical-analysis-of-ten-varieties-of-pawpaw-asimina-triloba-l-dunal-fruit-pulp
#5
Robert G Brannan, Trisha Peters, Stephen T Talcott
Pawpaw (Asimina triloba [L.] Dunal) is a tree fruit with the potential to become a high-value fruit crop, however, its rapid perishability is a significant obstacle. The objective was to determine the phytochemical content and quality characteristics of pawpaw pulp from ten varieties. This study reports for the first time the mass spectral characterization of phenolic acids and flavonoids of pawpaw, which indicated that the predominant polyphenolic compounds were three phenolic acids, protocatechuic acid hexoside, p-coumaroyl hexoside, and 5-O-p-coumaroylquinic acid, and flavonols, particularly (-)-epicatechin, B-type procyanidin dimers and trimers...
February 1, 2015: Food Chemistry
https://www.readbyqxmd.com/read/23441686/comparative-study-of-chromatographic-medium-associated-mass-and-potential-antitumor-activity-loss-with-bioactive-extracts
#6
Sandipan Datta, Yu-Dong Zhou, Dale G Nagle
Natural product drug discovery programs often rely on the use of silica (Si) gel, reversed-phase media, or size-exclusion resins (e.g., RP-C18, Sephadex LH-20) for compound purification. The synthetic polymer-based sorbent Diaion HP20SS (cross-linked polystyrene matrix) is used as an alternative to prepare purified natural product libraries. To evaluate the impact of chromatographic media on the isolation of biologically active, yet chromatographically unstable natural products, Diaion HP20SS was evaluated side-by-side with normal-phase sorbents for irreversible binding of extract constituents and their effects on bioactivity...
April 26, 2013: Journal of Natural Products
https://www.readbyqxmd.com/read/22130466/annonacin-in-asimina-triloba-fruit-implication-for-neurotoxicity
#7
Lisa F Potts, Frederick A Luzzio, Scott C Smith, Michal Hetman, Pierre Champy, Irene Litvan
INTRODUCTION: The acetogenin, annonacin, from the tropical annonaceous plant Annona muricata, is a lipophilic, mitochondrial complex I inhibitor reported to be more toxic than rotenone to mesencephalic neurons. The temperate annonaceous plant Asimina triloba (pawpaw) is native to the Eastern United States and products are available online. This study determined whether annonacin is in the pawpaw fruit pulp and whether it or the crude ethyl acetate extract is toxic to cortical neurons...
January 2012: Neurotoxicology
https://www.readbyqxmd.com/read/21562762/in-vitro-trematocidal-effects-of-crude-alcoholic-extracts-of-artemisia-annua-a-absinthium-asimina-triloba-and-fumaria-officinalis-trematocidal-plant-alcoholic-extracts
#8
Jorge F S Ferreira, Paul Peaden, Jennifer Keiser
Trematode infections negatively affect human and livestock health, and threaten global food safety. The only approved human anthelmintics for trematodiasis are triclabendazole and praziquantel with no alternative drugs in sight. We tested six crude plant extracts against adult Schistosoma mansoni, Fasciola hepatica, and Echinostoma caproni in vitro. Mortality was best achieved by ethanolic extracts of Artemisia annua (sweet Annie), Asimina triloba (paw-paw), and Artemisia absinthium (wormwood) which, at 2 mg/mL, killed S...
December 2011: Parasitology Research
https://www.readbyqxmd.com/read/20423107/the-alternative-medicine-pawpaw-and-its-acetogenin-constituents-suppress-tumor-angiogenesis-via-the-hif-1-vegf-pathway
#9
Veena Coothankandaswamy, Yang Liu, Shui-Chun Mao, J Brian Morgan, Fakhri Mahdi, Mika B Jekabsons, Dale G Nagle, Yu-Dong Zhou
Products that contain twig extracts of pawpaw (Asimina triloba) are widely consumed anticancer alternative medicines. Pawpaw crude extract (CE) and purified acetogenins inhibited hypoxia-inducible factor-1 (HIF-1)-mediated hypoxic signaling pathways in tumor cells. In T47D cells, pawpaw CE and the acetogenins 10-hydroxyglaucanetin (1), annonacin (2), and annonacin A (3) inhibited hypoxia-induced HIF-1 activation with IC(50) values of 0.02 microg/mL, 12 nM, 13 nM, and 31 nM, respectively. This inhibition correlates with the suppression of the hypoxic induction of HIF-1 target genes VEGF and GLUT-1...
May 28, 2010: Journal of Natural Products
https://www.readbyqxmd.com/read/19711911/identification-of-annonaceous-acetogenins-in-the-ripe-fruit-of-the-north-american-pawpaw-asimina-triloba
#10
COMPARATIVE STUDY
Kirk W Pomper, Jeremiah D Lowe, Sheri B Crabtree, William Keller
The North American pawpaw [ Asimina triloba (L.) Dunal] is a tree fruit in the early stages of commercial production in the United States. This plant contains annonaceous acetogenins in the twigs, unripe fruit, seeds, roots, and bark tissues, which display antitumor, pesticidal, antimalarial, anthelmintic, piscicidal, antiviral, and antimicrobial effects, suggesting many potentially useful applications. However, commercial development of these compounds, based on twig extracts, has been problematic due to limited availability of biomass for extraction...
September 23, 2009: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/19069999/agrobacterium-rhizogenes-mediated-transformation-of-asimina-triloba-l-cuttings
#11
Tomas Ayala-Silva, Caula A Beyl, Greg Dortch
The current research compared rooting of pawpaw, with softwood cuttings from mature stands, cuttings from the terminal 3-4 inches of seedlings and cuttings taken from shoots of rooted cuttings from seedlings. Four treatments were used: Agrobacterium rhizogenes strain MSU-1 (A4 wild type), A. rhizogenes strain MT232 (TR105 mutant), indole-3-butyric acid at 20,000 mg L(-1) and control. Only the A. rhizogenes treatments induced rooting and only of the seedling cuttings. No statistical differences in rooting percentage were found among the bacterial strains...
January 1, 2007: Pakistan Journal of Biological Sciences: PJBS
https://www.readbyqxmd.com/read/18983162/loss-of-ripening-capacity-of-pawpaw-fruit-with-extended-cold-storage
#12
Federica Galli, Douglas D Archbold, Kirk W Pomper
The fruit ripening traits of pawpaw [ Asimina triloba (L.) Dunal] were examined after harvest and after cold storage at -2, 2, 4, and 6 degrees C for up to 12 weeks. Generally, fruits stored at 2-4 degrees C for 4 weeks ripened normally, but those stored at -2 degrees C did not ripen normally, those stored at 6 degrees C were overripe, and by 6-8 weeks those stored at 2-4 degrees C had a lower respiration rate and ethylene production, lower firmness, and lower pH than fruit cold-stored for 4 weeks or less. These changes, and the occasional development of brown discoloration in the pulp once the fruits were moved back to room temperature, were evidence of chilling injury by 6 weeks...
November 26, 2008: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/18598079/paw-paw-and-cancer-annonaceous-acetogenins-from-discovery-to-commercial-products
#13
REVIEW
Jerry L McLaughlin
Extracts of paw paw ( Asimina triloba, Annonaceae) are among the most potent of the 3500 species of higher plants screened for bioactive compounds in our laboratories at Purdue University. The paw paw is a small tree native to eastern North America; its edible fruits (sometimes referred to as "Indiana Bananas") have nurtured mankind for centuries. Activity-directed fractionation of the paw paw extracts, using the brine shrimp lethality bioassay, led to the isolation and molecular characterization of over 50 unique annonaceous acetogenins...
July 2008: Journal of Natural Products
https://www.readbyqxmd.com/read/16830182/a-sine-family-widely-distributed-in-the-plant-kingdom-and-its-evolutionary-history
#14
Jeffrey A Fawcett, Taihachi Kawahara, Hitoshi Watanabe, Yasuo Yasui
The distribution and evolution of Au SINE in plants were examined. Au SINE is a short interspersed element first identified in Aegilops umbellulata, a close relative of wheat. The Au SINE was previously found in species such as wheat, maize, tobacco, and tomato, but not in rice. In this study, we first searched public databases, and next examined the presence of Au in a broad range of plant species by PCR using internal primers of Au. Although Au is likely to be absent from many species including rice, it was identified in many Gramineae, Solanaceae, and Fabaceae species, and also in a basal angiosperm species, Asimina triloba...
June 2006: Plant Molecular Biology
https://www.readbyqxmd.com/read/16187107/responses-of-floodplain-forest-species-to-spatially-condensed-gradients-a-test-of-the-flood-shade-tolerance-tradeoff-hypothesis
#15
COMPARATIVE STUDY
L L Battaglia, R R Sharitz
Previous work in southeastern US floodplains led to the hypothesis that a tradeoff between flood and shade tolerance underlies species-specific responses to flooding and light, which drive forest regeneration. In systems where community turnover can occur with small-scale environmental changes, testing this hypothesis requires recognizing that turnover of species along the two gradients can be large relative to the spatial distances involved. We test the tradeoff hypothesis in an old-growth bottomland hardwood forest by (1) comparing shade and moisture profiles of woody juveniles versus random points and (2) using individual-based sampling of woody juveniles to model probability of occurrence in response to distance-to-water table and canopy openness gradients...
February 2006: Oecologia
https://www.readbyqxmd.com/read/15730242/asimitrin-and-4-hydroxytrilobin-new-bioactive-annonaceous-acetogenins-from-the-seeds-of-asimina-triloba-possessing-a-bis-tetrahydrofuran-ring
#16
Eun Jung Kim, Kyung Mi Suh, Dal Hwan Kim, Eun Joo Jung, Chang Seob Seo, Jong Keun Son, Mi Hee Woo, Jerry L McLaughlin
Bioactivity-directed fractionation of the seeds of Asimina triloba resulted in the isolation of asimitrin (1) and 4-hydroxytrilobin (2). Compound 1 represents an adjacent ring-hydroxylated bis-tetrahydrofuran (THF) acetogenin. Compound 2 has an adjacent bis-THF ring with two flanking hydroxyl groups and a alpha,beta-unsaturated gamma-lactone with a 4-hydroxyl group. Compounds 1 and 2 showed cytotoxic selectivity, with 100-10 000 times the potency of adriamycin against prostate adenocarcinoma (PC-3) and colon adenocarcinoma (HT-29) cell lines...
February 2005: Journal of Natural Products
https://www.readbyqxmd.com/read/14283689/-alkaloids-of-asimina-triloba-dunal
#17
M TOMITA, M KOZUKA
No abstract text is available yet for this article.
January 1965: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/12757326/combined-roles-of-contact-stimulant-and-deterrents-in-assessment-of-host-plant-quality-by-ovipositing-zebra-swallowtail-butterflies
#18
Meena Haribal, Paul Feeny
Zebra swallowtail (Eurytides marcellus) butterflies are stimulated to oviposit by a single compound, 3-caffeoyl-muco-quinic acid (1). Analysis of the aqueous extracts of the leaves of the host. Asimina triloba, showed that they contained stimulant 1, its isomer (2), and the flavonoids rutin (3) and nicotiflorine (4) as major components. We compared the concentrations of compounds 1-4 in terminal leaves (TL) and expanded leaves (EL) of the host plants at four different times throughout the growing season. In spring, the concentration of 1 was highest in TLs, and flavonoids were not detectable or present at low levels...
March 2003: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/11087592/asitrocin-2-4-cis-and-trans-asitrocinones-novel-bioactive-mono-tetrahydrofuran-acetogenins-from-asimina-triloba-seeds
#19
E J Kim, F Tian, M H Woo
Asitrocin (1) and the mixture of (2,4)-cis- and trans-asitrocinones (2 and 3), new bioactive Annonaceous acetogenins, were isolated from the seeds of Asimina triloba by activity-directed fractionation using the brine shrimp lethality test. Asitrocin and the mixture of (2,4)-cis- and trans-asitrocinones have a configuration of erythro/trans/threo from C-15 to C-20, the mono-THF moiety with two flanking hydroxyl groups. The structures were determined by spectroscopic methods. These acetogenins showed potent bioactivities in the brine shrimp lethality test (BST) and among six human solid tumor cell lines with notable selectivity for the prostate (PC-3) and the pancreatic (MIA PaCa-2) cell lines at 10-100 times the potency of adriamycin...
November 2000: Journal of Natural Products
https://www.readbyqxmd.com/read/10968288/asitrilobins-c-and-d-two-new-cytotoxic-mono-tetrahydrofuran-annonaceous-acetogenins-from-asimina-triloba-seeds
#20
M H Woo, S O Chung, D H Kim
Two new bioactive mono-tetrahydrofuran (THF) gamma-lactone acetogenins, asitrilobins C (1) and D (2), were isolated from the seeds of Asimina triloba (Annonaceae) by directing the fractionation with brine shrimp lethality. Compounds 1 and 2 have a relative stereochemical relationship of threo/trans/threo across the mono-THF ring with its two flanking hydroxyls. Their structures were established on the basis of chemical and spectral evidence. Compounds 1 and 2 showed selective cytotoxicity comparable with adriamycin for the breast carcinoma (MCF-7) and the colon adenocarcinoma (HT-29) cell lines...
January 2000: Bioorganic & Medicinal Chemistry
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