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https://www.readbyqxmd.com/read/28812277/milonine-an-alkaloid-of-cissampelos-sympodialis-eichl-menispermaceae-inhibits-histamine-release-of-activated-mast-cells
#1
Adriano Francisco Alves, Giciane Carvalho Vieira, Francisco Allysson A F Gadelha, Luiz Henrique Agra Cavalcante-Silva, Marco Aurélio Martins, José Maria Barbosa-Filho, Marcia Regina Piuvezam
Milonine is an alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae), a plant used in the northeast of Brazil to treat allergies such as asthma, rhinitis, and other conditions. Previously, several alkaloids were isolated from its roots and leaves with pharmacological properties in asthma and acute inflammation models. Therefore, the aim of this study was to evaluate the milonine effect on mast cells degranulation in vivo and in vitro. Swiss mice (n = 8) were used in models of paw edema induced by carrageenan, compound 48/80, or histamine...
August 15, 2017: Inflammation
https://www.readbyqxmd.com/read/28811678/patchoulene-epoxide-isolated-from-patchouli-oil-suppresses-acute-inflammation-through-inhibition-of-nf-%C3%AE%C2%BAb-and-downregulation-of-cox-2-inos
#2
Jia-Li Liang, Jia-Zhen Wu, Yu-Hong Liu, Zhen-Biao Zhang, Qi-Duan Wu, Han-Bin Chen, Yan-Feng Huang, Yao-Xing Dou, Jiang-Tao Zhou, Zi-Ren Su, Janis Ya-Xian Zhan
According to the GC-MS analysis, compositional variation was observed between samples of patchouli oil, of which an unknown compound identified as patchoulene epoxide (PAO) was found only in the long-stored oil, whose biological activity still remains unknown. Therefore, the present study aimed to evaluate the potential anti-inflammatory activity with three in vivo inflammatory models: xylene-induced ear edema, acetic acid-induced vascular permeability, and carrageenan-induced paw edema. Further investigation into its underlying mechanism on carrageenan-induced paw edema was conducted...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28810506/controls-on-anastomosis-in-lowland-river-systems-towards-process-based-solutions-to-habitat-conservation
#3
Paweł Marcinkowski, Robert C Grabowski, Tomasz Okruszko
Anastomosing rivers were historically common around the world before extensive agricultural and industrial development in river valleys. Few lowland anastomosing rivers remain in temperate zones, and the protection of these river-floodplain systems is an international conservation priority. However, the mechanisms that drive the creation and maintenance of multiple channels, i.e. anabranches, are not well understood, particularly for lowland rivers, making it challenging to identify effective management strategies...
August 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28808058/reductions-in-the-mitochondrial-abc-transporter-abcb10-affect-the-transcriptional-profile-of-heme-biosynthesis-genes
#4
Alexandra Seguin, Naoko Takahashi-Makise, Yvette Y Yien, Nicholas C Huston, Jared C Whitman, Gabriel Musso, Jared A Wallace, Thomas Bradley, Hector Bergonia, Martin D Kafina, Mitsuyo Matsumoto, Kazuhiko Igarashi, John D Phillips, Barry H Paw, Jerry Kaplan, Diane M Ward
ATP-binding cassette subfamily B member 10 (Abcb10) is a mitochondrial ABC transporter that complexes with mitoferrin1 and ferrochelatase to enhance heme biosynthesis in developing red blood cells. Reductions in Abcb10 levels have been shown to reduce mitoferrin1 protein levels and iron import into mitochondria resulting in reduced heme biosynthesis. As an ABC transporter, Abcb10 binds and hydrolyzes ATP, but its transported substrate is unknown. Here, we determined that decreases in Abcb10 did not result in protoporphyrin IX accumulation in morphant treated zebrafish embryos nor in differentiated Abcb10-specific shRNA murine Friend erythroleukemia (MEL) cells in which Abcb10 was specifically silenced with shRNA...
August 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28807786/dexmedetomidine-prolongs-levobupivacaine-analgesia-via-inhibition-of-inflammation-and-p38-mapk-phosphorylation-in-rat-dorsal-root-ganglion
#5
Shunsuke Yamakita, Megumi Matsuda, Yosuke Yamaguchi, Teiji Sawa, Fumimasa Amaya
Following tissue injury, phosphorylation of p38 MAPK in the primary afferent neurons drives sensitization of peripheral nerve. Dexmedetomidine extends the duration of reginal analgesia by local anesthetics. The effect of regional analgesia on the peripheral nerve sensitization is not known. The aim of this study is to investigate the effect of regional analgesia by levobupivacaine with or without dexmedetomidine on the p38 MAPK phosphorylation in the dorsal root ganglion (DRG) and inflammatory reaction in the peripheral tissue...
August 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/28806653/novel-microemulsion-based-gels-for-topical-delivery-of-indomethacin-formulation-physicochemical-properties-and-in-vitro-drug-release-studies
#6
Anna Froelich, Tomasz Osmałek, Agnieszka Snela, Paweł Kunstman, Barbara Jadach, Marta Olejniczak, Grzegorz Roszak, Wojciech Białas
HYPOTHESIS: Microemulsion-based semisolid systems may be considered as an interesting alternative to the traditional dosage forms applied in topical drug delivery. Mechanical properties of topical products are important both in terms of application and dosage form effectiveness. In this study we designed and evaluated novel microemulsion-based gels with indomethacin and analyzed the factors affecting their mechanical characteristics and drug release. EXPERIMENTS: The impact of the microemulsion composition on the extent of isotropic region was investigated with the use of pseudoternary phase diagrams...
August 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28806224/bromodomain-containing-protein-4-activates-voltage-gated-sodium-channel-1-7-transcription-in-dorsal-root-ganglia-neurons-to-mediate-thermal-hyperalgesia-in-rats
#7
Ming-Chun Hsieh, Yu-Cheng Ho, Cheng-Yuan Lai, Hsueh-Hsiao Wang, An-Sheng Lee, Jen-Kun Cheng, Yat-Pang Chau, Hsien-Yu Peng
BACKGROUND: Bromodomain-containing protein 4 binds acetylated promoter histones and promotes transcription; however, the role of bromodomain-containing protein 4 in inflammatory hyperalgesia remains unclear. METHODS: Male Sprague-Dawley rats received hind paw injections of complete Freund's adjuvant to induce hyperalgesia. The dorsal root ganglia were examined to detect changes in bromodomain-containing protein 4 expression and the activation of genes involved in the expression of voltage-gated sodium channel 1...
August 11, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28806085/resolving-discrepancy-between-theory-and-experiment-in-4-nitrotoluene-oxidation
#8
Kamila Klajman, Grzegorz Ciepielowski, Rafal Kaminski, Paweł Adamczyk, Piotr Paneth
We have performed calculations of possible oxidation pathways of 4-nitrotoluene (4NT) by permanganate anion and evaluated relative contributions of oxidation of the methyl group and aromatic ring. Although a few theory levels matched experimental results obtained by Compound Specific Isotope Analysis (CSIA) for 4NT, they failed in reproducing results for other nitrotoluene derivatives studied previously[Wijker, R.S.; Adamczyk, P.; Bolotin, J.; Paneth, P.; Hofstetter, T.B. Environ. Sci. Technol., 2013, 47, 13459-13468]...
August 14, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28805082/veterans-transitioning-from-isolation-to-integration-a-look-at-veteran-service-dog-partnerships
#9
Terry K Crowe, Victoria Sánchez, Alyse Howard, Brenna Western, Stephanie Barger
BACKGROUND: This study explored the dynamics of veteran/service dog partnerships by gathering the perspectives of veterans with a history of post-traumatic stress disorder and/or traumatic brain injury. METHODS: Exploratory qualitative methods (focus groups and individual interviews) were used to investigate veteran/service dog relationships related to community involvement, family and friend relationships, self-care, work, and leisure. Nine male veterans, Paws, and Stripes program graduates participated...
August 13, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28803751/insulin-prevents-aberrant-mitochondrial-phenotype-in-sensory-neurons-of-type-1-diabetic-rats
#10
Mohamad-Reza Aghanoori, Darrell R Smith, Subir Roy Chowdhury, Mohammad Golam Sabbir, Nigel A Calcutt, Paul Fernyhough
Diabetic neuropathy affects approximately 50% of diabetic patients. Down-regulation of mitochondrial gene expression and function has been reported in both human tissues and in dorsal root ganglia (DRG) from animal models of type 1 and type 2 diabetes. We hypothesized that loss of direct insulin signaling in diabetes contributes to loss of mitochondrial function in DRG neurons and to development of neuropathy. Sensory neurons obtained from age-matched adult control or streptozotocin (STZ)-induced type 1 diabetic rats were cultured with or without insulin before determining mitochondrial respiration and expression of mitochondrial respiratory chain and insulin signaling-linked proteins...
August 10, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28803641/the-assessment-of-risk-factors-for-febrile-seizures-in-children
#11
Krystyna Gontko-Romanowska, Zbigniew Żaba, Paweł Panieński, Barbara Steinborn, Michał Szemień, Magdalena Łukasik-Głębocka, Krystian Ratajczak, Adrian Chrobak, Joanna Mitkowska, Jacek Górny
OBJECTIVE: The aim of the paper was to assess the risk factors of febrile seizures in children. METHODS: The paper presents an analysis of a group of 176 children aged 6 months to 5 years who were admitted to A&E because of febrile seizures. RESULTS: The analysed group of 176 children comprised 61.96% boys and 38.07% girls, and the average age equalled 23 months. Family history was significant in 9.66% of patients. A statistically significant difference was noticed between insignificant family history and the incidence of febrile seizures...
July 31, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28803200/ecological-state-of-a-mountain-river-before-and-after-a-large-flood-implications-for-river-status-assessment
#12
Hanna Hajdukiewicz, Bartłomiej Wyżga, Antoni Amirowicz, Paweł Oglęcki, Artur Radecki-Pawlik, Joanna Zawiejska, Paweł Mikuś
Assessment of the ecological status of rivers is key to monitoring the achievement of the environmental goal of the EU Water Framework Directive and the success of restoration projects. In summer of 2009 and 2010, repeated assessments of physical habitat conditions and of fish and benthic invertebrate communities were performed at low-flow conditions in 10 unmanaged and 10 channelized cross-sections of the Biała River, Polish Carpathians. Between the two surveys, an 80-year flood occurred, significantly affecting habitat characteristics and river communities...
August 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28803177/clusterin-a-new-cerebrospinal-fluid-biomarker-in-severe-subarachnoid-haemorrhage-a-pilot-study
#13
Norbert Wąsik, Bartosz Sokół, Marcin Hołysz, Witold Mańko, Robert Juszkat, Piotr Paweł Jagodziński, Roman Jankowski
BACKGROUND: Inflammation following subarachnoid haemorrhage (SAH) employs numerous mediators with biomarker properties. Preliminary studies indicated that clusterin, a multifunctional chaperon protein, was a potential biomarker in SAH. We aim to clarify the status of clusterin in SAH. METHOD: 47 CSF samples were collected on post-SAH days 0-3, 5-7, and 10-14 from 27 patients with severe SAH. Control CSF was collected from 25 age- and sex- matched healthy patients undergoing spinal anaesthesia for minor surgery...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28803134/age-related-changes-of-physiological-performance-and-survivorship-of-bank-voles-selected-for-high-aerobic-capacity
#14
Agata Marta Rudolf, Maciej Jan Dańko, Edyta Teresa Sadowska, Geoffrey Dheyongera, Paweł Koteja
Variation in lifespans is an intriguing phenomenon, but how metabolic rate influence this variation remains unclear. High aerobic capacity can result in health benefits, but also in increased oxidative damage and accelerated ageing. We tested these contradictory predictions using bank voles (Myodes=Clethrionomys glareolus) from lines selected for high swim-induced aerobic metabolism (A), which had about 50% higher maximum metabolic rate and a higher basal and routine metabolic rates, than those from unselected control lines (C)...
August 9, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28802535/the-effects-of-autologous-platelet-rich-fibrin-on-flexor-tendon-healing-in-a-rabbit-model
#15
Janice C Y Liao, Min He, Aaron W T Gan, Alphonsus K S Chong
PURPOSE: Platelet-rich plasma containing large amounts of growth factors is purported to increase repaired flexor tendon strength. However, the use of bovine thrombin has the risk of antibody formation. We evaluated the effects of the newer generation autologous platelet-rich fibrin (PRF) on flexor tendon healing. METHODS: We performed surgical repair of 32 flexor tendons from the index and ring digits of the hind paws of 8 New Zealand white rabbits. In the PRF group, the PRF membrane was either wrapped around or interposed between the repair sites...
August 9, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28801791/effectiveness-of-healthcare-coordination-in-patients-with-chronic-respiratory-diseases
#16
Donata Kurpas, Katarzyna Szwamel, Dorota Lenarcik, Marika Guzek, Artur Prusaczyk, Paweł Żuk, Jolanta Michalowska, Agnieszka Grzeda, Bożena Mroczek
Coordination of healthcare effectively prevents exacerbations and reduces the number of hospitalizations, emergency visits, and the mortality rate in patients with chronic respiratory diseases. The purpose of this study was to determine clinical effectiveness of ambulatory healthcare coordination in chronic respiratory patients and its effect on the level of healthcare services as an indicator of direct medical costs. We conducted a retrospective health record survey, using an online database of 550 patients with chronic respiratory diseases...
August 12, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28801761/milonine-a-morphinandienone-alkaloid-has-anti-inflammatory-and-analgesic-effects-by-inhibiting-tnf-%C3%AE-and-il-1%C3%AE-production
#17
Larissa Rodrigues Silva, Adriano Francisco Alves, Luiz Henrique Agra Cavalcante-Silva, Renan Marinho Braga, Reinaldo Nóbrega de Almeida, José Maria Barbosa-Filho, Márcia Regina Piuvezam
Milonine is a morphinandienone alkaloid from Cissampelos sympodialis Eichl (Menispermaceae), a plant used in Brazil to treat inflammatory disorders. In this study, we evaluated the anti-inflammatory and analgesic activity of milonine (MIL) by using classical experimental models of inflammation and nociception. The results showed that MIL reduced the paw edema formation induced by lipopolysaccharide, prostaglandin E2, and bradykinin, without interfering with the serotonin-induced edema. With respect to the nociception experiments, MIL decreased the exudate into the peritoneum induced by acetic acid, maintaining the tissue morphology...
August 11, 2017: Inflammation
https://www.readbyqxmd.com/read/28800942/plasma-and-ovarian-tissue-sphingolipids-profiling-in-patients-with-advanced-ovarian-cancer
#18
Paweł Knapp, Lubomir Bodnar, Agnieszka Błachnio-Zabielska, Magdalena Świderska, Adrian Chabowski
PURPOSE: The role of lipids in carcinogenesis through induction of abnormal cell lines in the human body is currently undisputable. Based on the literature, bioactive sphingolipids play an essential role in the development and progression of cancer and are involved in the metastatic process. The aim of this study was to determine the concentration of selected sphingolipids in patients with advanced ovarian cancer (AOC, FIGO III/IV, high grade ovarian cancer). METHODS: Seventy-four patients with ovarian cancer were enrolled...
August 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28798953/the-ethanolic-stem-bark-extract-of-antrocaryon-micraster-inhibits-carrageenan-induced-pleurisy-and-pedal-oedema-in-murine-models-of-inflammation
#19
Leslie B Essel, David D Obiri, Newman Osafo, Aaron O Antwi, Babatunde M Duduyemi
We investigated the antioxidant and anti-inflammatory effects of a 70% v/v ethanol extract of the stem bark of Antrocaryon micraster on murine models of carrageenan-induced pleurisy and paw oedema. Rat pleural fluid was analysed for volume, protein content, and leucocytes, while lung histology was assessed for damage. Lung tissue homogenates were assayed for glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and myeloperoxidase (MPO). Phytochemical analysis was carried out on the stem bark...
2017: International Scholarly Research Notices
https://www.readbyqxmd.com/read/28798793/the-diagnostic-role-of-cardiac-magnetic-resonance-used-first-and-last-time-in-life-in-a-patient-with-a-suspected-dilated-phase-of-hypertrophic-cardiomyopathy
#20
Rafał Hładij, Renata Rajtar-Salwa, Artur Dziewierz, Paweł Petkow-Dimitrow
No abstract text is available yet for this article.
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
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