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https://www.readbyqxmd.com/read/28317156/synthesis-and-anticonvulsant-properties-of-new-3-3-diphenyl-2-5-dioxo-pyrrolidin-1-yl-acetamides-and-3-3-diphenyl-propionamides
#1
Jolanta Obniska, Anna Rapacz, Sabina Rybka, Małgorzata Góra, Paweł Żmudzki, Krzysztof Kamiński
The focused library of new amides derived from 3,3-diphenyl-2,5-dioxo-pyrrolidin-1-yl-acetic acid (2a-t) and 3,3-diphenyl-propionic acid (3a-t) as potential anticonvulsant agents was synthesized. The final products were obtained in the amidation reaction of the given carboxylic acid (2, 3) with appropriate secondary amines in the presence of carbonyldiimidazole (CDI) as a coupling reagent. The initial anticonvulsant screening was performed in mice intraperitoneally (i.p.) using the "classical" maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizure models, whereas the acute neurological toxicity was determined applying the rotarod test...
March 20, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28317135/free-mycophenolic-acid-determination-in-human-plasma-ultrafiltrate-by-a-validated-liquid-chromatography-tandem-mass-spectrometry-method
#2
Paulina Łuszczyńska, Tomasz Pawiński, Paweł K Kunicki, Katarzyna Sikorska, Ryszard Marszałek
OBJECTIVES: The aim of this study was to develop and fully validate LC-MS/MS method for free mycophenolic acid (MPA) concentration measurements in plasma ultrafiltrate that will be reliable and simple in preparation with deuterated MPA (MPA-d3) chosen as an internal standard. METHODS: The chromatographic separation was made with Zorbax Eclipse XDB-C18 column (4.6x150 mm) using a gradient of two solutions as a mobile phase: A) water and B) methanol, each containing 0...
March 20, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/28316983/endovenous-laser-ablation-of-varicose-veins-preserves-biological-properties-of-vascular-endothelium-and-modulates-proinflammatory-agent-profile-more-favorably-than-classic-vein-stripping
#3
Paweł Uruski, Krzysztof Aniukiewicz, Justyna Mikuła-Pietrasik, Patrycja Sosińska, Andrzej Tykarski, Krzysztof Książek, Zbigniew Krasiński
Here we compared effect of serum from varicose patients undergoing endovenous laser ablation (EVLA) and classic vein stripping (CVS) on biological properties of endothelial cells and on the local and systemic profiles of proinflammatory agents. Results showed that serum from EVLA patients improved proliferation and reduced senescence and oxidative stress in the endothelial cells, as compared with the serum from CVS patients. These effects were related to a suppressed activity of TGF-β1, the level of which in the serum from the EVLA patients was decreased...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28315389/variations-in-the-chemical-composition-and-content-of-salicylic-glycosides-in-the-bark-of-salix-purpurea-from-natural-locations-and-their-significance-for-breeding
#4
Paweł Sulima, Mirosława Krauze-Baranowska, Jerzy Andrzej Przyborowski
Willow bark is one of the few plant raw materials which contain natural active substances that have analgesic, fever-reducing, anti-inflammatory and anti-rheumatic effects. Salix purpurea, listed as widespread and common in many countries, belongs to the willow species with the highest content of salicylic compounds. The chemical composition and content of major salicylic glycosides (SGs) in the bark of S. purpurea genotypes from natural locations were investigated in this study to evaluate their applicability for pharmaceutical processing and creative breeding...
March 15, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28306605/hyperalgesic-priming-type-ii-induced-by-repeated-opioid-exposure-maintenance-mechanisms
#5
Dioneia Araldi, Luiz F Ferrari, Jon D Levine
We previously developed a model of opioid-induced neuroplasticity in the peripheral terminal of the nociceptor that could contribute to opioid-induced hyperalgesia, type II hyperalgesic priming. Repeated administration of mu-opioid receptor (MOR) agonists, such as DAMGO, at the peripheral terminal of the nociceptor, induces long-lasting plasticity expressed, prototypically as opioid-induced hyperalgesia and prolongation of prostaglandin-E2-induced hyperalgesia. In this study, we evaluated the mechanisms involved in the maintenance of type II priming...
March 14, 2017: Pain
https://www.readbyqxmd.com/read/28303702/studies-on-the-quality-nutrition-in-women-with-polycystic-ovary-syndrome-pcos
#6
Małgorzata Szczuko, Patrycja Sankowska, Marta Zapałowska-Chwyć, Paweł Wysokiński
Background: Polycystic ovary syndrome (PCOS) manifests itself with various symptoms, therefore it interests representatives of many medical specializations: general practitioners, gynecologists, endocrinologists, dermatologists, cardiologists and those who deal with metabolic disorders, such as dieticians. Objective: The aim of this study was perform the qualitative assessment of components of diets of women with PCOS as one of the major factor contributing to the disease...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28303697/review-of-the-studies-on-nutrition-in-polish-preschool-children-part-2-meals-prepared-at-preschool
#7
Sylwia Merkiel-Pawłowska, Wojciech Chalcarz
This article is the second part of the review of the studies on nutrition in Polish preschool children. In the first part, studies on preschool menus assessment were presented and summarised, whereas this article reviews the studies on the assessment of foods and meals prepared at preschool. The aim of this review was to present and summarise the results of the studies on the assessment of meals prepared for children at preschool based on the reports from the preschool food storeroom, the studies on chemical analysis of sample meals served at preschools and the studies on comparison of the results of chemical analysis to the results obtained by calculations obtained from computer programmes...
2017: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/28301318/antihypernociceptive-and-antioxidant-effects-of-petersianthus-macrocarpus-stem-bark-extracts-in-rats-with-complete-freund-s-adjuvant-induced-persistent-inflammatory-pain
#8
Francis Desire Tatsinkou Bomba, Bibiane Aimée Wandji, Christian Kuete Fofié, Albert Kamanyi, Télesphore Benoit Nguelefack
Background Petersianthus macrocarpus (P. Beauv.) Liben (Lecythidaceae) is a plant used in Cameroonian folk medicine to cure ailments such as inflammation and pain. Previous work showed that aqueous (AEPM) and methanol (MEPM) extracts from the stem bark of P. macrocarpus possess acute analgesic activities. The present study evaluates whether the same extracts could inhibit persistent hyperalgesia induced by complete Freund's adjuvant (CFA) in rats. Methods Inflammatory pain was induced by intraplantar injection of CFA into the left hind paw of Wistar rats...
March 15, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28300633/the-medullary-dorsal-reticular-nucleus-as-a-relay-for-descending-pronociception-induced-by-the-mglur5-in-the-rat-infralimbic-cortex
#9
Ana David-Pereira, Boriss Sagalajev, Hong Wei, Armando Almeida, Antti Pertovaara, Filipa Pinto-Ribeiro
Metabotropic glutamate receptor 5 (mGluR5) activation in the infralimbic cortex (IL) induces pronociceptive behavior in healthy and monoarthritic rats. Here we studied whether the medullary dorsal reticular nucleus (DRt) and the spinal TRPV1 are mediating the IL/mGluR5-induced spinal pronociception and whether the facilitation of pain behavior is correlated with changes in spinal dorsal horn neuron activity. For drug administrations, all animals had a cannula in the IL as well as a cannula in the DRt or an intrathecal catheter...
March 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/28299528/dietary-conjugated-linoleic-acid-c9t11-prevents-collagen-induced-arthritis-whereas-conjugated-linoleic-acid-t10c12-increases-arthritic-severity
#10
Jessica A Muhlenbeck, Daniel E Butz, Jake M Olson, Daniela Uribe-Cano, Mark E Cook
Two conjugated linoleic acid (CLA) isomers, cis-9, trans-11 (CLAc9t11) and trans-10, cis-12 (CLAt10c12), reduce inflammation in a number of animal models, including collagen-induced arthritis (CA). However, little is known about the ability of individual CLA isomers to prevent autoimmune disease onset. Evidence that mixed isomer CLA drives T helper cell (Th) 1 responses suggests that CLA, or a specific isomer, exacerbates onset of Th1 autoimmune diseases. In two experiments, we examined if prior dietary exposure to CLAt10c12 (experiment 1) or CLAc9t11 (experiment 2) affected the incidence or severity of CA...
March 15, 2017: Lipids
https://www.readbyqxmd.com/read/28299318/application-of-pneumatic-lithotripter-and-holmium-laser-in-the-treatment-of-ureteral-stones-and-kidney-stones-in-children
#11
Marcin Życzkowski, Rafał Bogacki, Krzysztof Nowakowski, Bartosz Muskała, Paweł Rajwa, Piotr Bryniarski, Andrzej Paradysz
Objective. Treatment options for urolithiasis in children include URSL and RIRS. Various types of energy are used in the disintegration of deposits in these procedures. We decided to evaluate the usefulness of URSL and RIRS techniques and compare the effectiveness of pneumatic lithotripters and holmium lasers in the child population based on our experience. Materials and Methods. One hundred eight (108) children who underwent URSL and RIRS procedures were enrolled in the study and divided into two (2) groups according to the type of energy used: pneumatic lithotripter versus holmium laser...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28298924/hematological-parameters-and-hemozoin-containing-leukocytes-and-their-association-with-disease-severity-among-malaria-infected-children-a-cross-sectional-study-at-pawe-general-hospital-northwest-ethiopia
#12
Muluken Birhanu, Yaregal Asres, Wondimagegn Adissu, Tilahun Yemane, Endalew Zemene, Lealem Gedefaw
Hematological parameter changes are the most common complications in malaria. We aimed to determine the hematological parameters and hemozoin-containing leukocytes and their association with disease severity in malaria infected children aged between 1 and 15 years. A facility-based cross-sectional study was conducted at Pawe General Hospital from July 31 to December 30, 2014. Demographic and clinical data were collected using structured questionnaire. Blood specimen was collected from each study participant for hematological investigations...
2017: Interdisciplinary Perspectives on Infectious Diseases
https://www.readbyqxmd.com/read/28298071/protective-effect-of-dracontium-dubium-against-bothrops-asper-venom
#13
Daneiva Caro, Yanet Ocampo, Jenny Castro, Lia Barrios, Rubén Salas, Luis A Franco
In Colombia, Bothrops asper is responsible for 70-90% of ophidians accidents reported annually. Envenoming occurs mainly in rural areas where both antivenom and health centers are scarce. Thus, patients are frequently treated by local healers that employ medicinal herbs; including several species belonging to Dracontium genus. In this work, we evaluated the neutralizing activity of Dracontium dubium Kunth against the lethal, inflammatory, coagulant and hemolytic effects produced by B. asper venom. Mice treated with D...
March 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28296883/soluble-insulin-analogs-combining-rapid-and-long-acting-hypoglycemic-properties-from-an-efficient-e-coli-expression-system-to-a-pharmaceutical-formulation
#14
Diana Mikiewicz, Anna Bierczyńska-Krzysik, Agnieszka Sobolewska, Dorota Stadnik, Monika Bogiel, Monika Pawłowska, Anna Wójtowicz-Krawiec, Piotr A Baran, Natalia Łukasiewicz, Agnieszka Romanik-Chruścielewska, Iwona Sokołowska, Jacek Stadnik, Piotr Borowicz, Grażyna Płucienniczak, Andrzej Płucienniczak
The discovery of insulin led to a revolution in diabetes management. Since then, many improvements have been introduced to insulin preparations. The availability of molecular genetic techniques has enabled the creation of insulin analogs by changing the structure of the native protein in order to improve the therapeutic properties. A new expression vector pIBAINS for production of four recombinant human insulin (INS) analogs (GKR, GEKR, AKR, SR) was constructed and overexpressed in the new E. coli 20 strain as a fusion protein with modified human superoxide dismutase (SOD)...
2017: PloS One
https://www.readbyqxmd.com/read/28296538/hemolytic-uremic-syndrome-findings-of-post-acute-renal-failure-in-light-and-electron-microscopy
#15
Wiesława Salwa-Żurawska, Jakub Żurawski, Aldona Woźniak, Elżbieta Bortkiewicz, Paweł Burchardt, Przemysław Kwiatkowski, Monika Seget, Piotr Tabaczewski
The blood count test results of six patients (five male adolescents and one female adult) who were diagnosed with the hemolytic-uremic syndrome are presented. Certain diverse lesions and especially, their different intensity, were observed. They were referred to the clinical process and the time from syndrome occurrence to biopsy.
March 15, 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28295853/matrine-regulates-th1-th2-cytokine-responses-in-rheumatoid-arthritis-by-attenuating-the-nf-%C3%AE-b-signaling
#16
Yaojie Niu, Qiumei Dong, Rongheng Li
To investigate the efficacy and mechanisms of matrine, a component derived from Sophora flavescens in treatment of rheumatoid arthritis (RA), a rat model of RA was established. Compared to control rats, matrine significantly mitigated inflammation and severity of RA (paw volume and articular index (AI) score). Using either mice splenic T cells stimulated with PMA/ionomycin or rat splenic T cells, the levels of Th1 and Th2 responses were determined by flow cytometry, quantitative RT-PCR and ELISA. Furthermore, the levels of NF-κBp65 (RelA), IκBα and phosphor-IκBα in T cells were determined by Western blot...
March 15, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28294366/antihyperalgesic-effects-of-indomethacin-ketorolac-and-metamizole-in-rats-effects-of-metformin
#17
Crystell Guadalupe Guzmán-Priego, Roberto Méndez-Mena, Manuel Alfonso Baños-González, Claudia Ivonne Araiza-Saldaña, Gabriela Castañeda-Corral, Jorge Elías Torres-López
Preclinical Research Metformin-dependent mechanisms have been implicated in the antinociceptive effect of some non-steroidal anti-inflammatory drugs (NSAIDs). In this study, the effect of local peripheral or systemic administration of metformin on the local peripheral or systemic antinociception induced by indomethacin, ketorolac and metamizole was assessed in the rat carrageenan-induced thermal hyperalgesia model. Rats were injected with carrageenan (1%, 50 µl) into the right hindpaw which reduced paw withdrawal latency, a measure of thermal hyperalgesia...
March 15, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28291541/evidence-for-a-novel-neurohumoral-antinociceptive-mechanism-mediated-by-peripheral-capsaicin-sensitive-nociceptors-in-conscious-rats
#18
Gábor Pethő, Kata Bölcskei, Réka Füredi, Bálint Botz, Teréz Bagoly, Erika Pintér, János Szolcsányi
Stimulation of capsaicin-sensitive peripheral sensory nerve terminals induces remote anti-inflammatory effects throughout the body of anesthetized rats and guinea-pigs mediated by somatostatin. As somatostatin has also antinociceptive effects, the study aimed at investigating whether similar remote antinociceptive effects can be demonstrated in awake animals. In conscious rats, nociceptive nerve endings of the right hind paw decentralized by cutting the sciatic and saphenous nerves 18h before were chemically stimulated, and drop of the noxious heat threshold (heat hyperalgesia) induced by prior (18h before) plantar incision was measured on the contralateral, left hind paw using an increasing-temperature water bath...
February 10, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28291470/comparative-efficacy-of-multiple-variables-of-mesenchymal-stem-cell-transplantation-for-the-treatment-of-neuropathic-pain-in-rats
#19
LiPing Liu, Zhen Hua, Jun Shen, Yan Yin, Jing Yang, Kathleen Cheng, Aijun Liu, Lina Wang, Jianguo Cheng
OBJECTIVES: The current treatment options for neuropathic pain due to nerve injuries are limited and largely unsatisfactory. Mesenchymal stem cell transplantation (MSC) has shown promise as an emerging therapy for neuropathic pain. However, a number of critical parameters, including the sources of cells, the number of cells, and routes of transplantation, need to be elucidated before it can be tested clinically. METHODS: MSCs were isolated from rat bone marrow (rBM-MSCs) and adipose tissue (rAD-MSCs) and characterized by flow cytometry and functional differentiation...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28290525/quantification-of-arthritic-bone-degradation-by-analysis-of-3d-micro-computed-tomography-data
#20
Carl-Magnus Svensson, Bianca Hoffmann, Ingo M Irmler, Maria Straßburger, Marc Thilo Figge, Hans Peter Saluz
The use of animal models of arthritis is a key component in the evaluation of therapeutic strategies against the human disease rheumatoid arthritis (RA). Here we present quantitative measurements of bone degradation characterised by the cortical bone profile using glucose-6-phosphate isomerase (G6PI) induced arthritis. We applied micro-computed tomography (μCT) during three arthritis experiments and one control experiment to image the metatarsals of the hind paws and to investigate the effect of experimental arthritis on their cortical bone profile...
March 14, 2017: Scientific Reports
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