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https://www.readbyqxmd.com/read/29145335/clavicle-fracture-associated-with-atlantoaxial-rotatory-displacement-type-ii-in-an-8-year-old-girl-a-case-report
#1
Jacek Karski, Łukasz Matuszewski, Paweł Jakubowski, Klaudia Karska, Grzegorz Kandzierski
RATIONALE: Fracture of the clavicle is a very common injury in children. However, association between clavicle fracture and atlantoaxial rotatory displacement is rarely observed. PATIENT CONCERNS: We present a case of an 8-year-old girl, who suffered a right clavicle fracture as a result of a sledge accident. Six weeks after figure of 8 casting for a right clavicle fracture, an 8-year-old girl was brought to the Pediatric Orthopedic Department due to torticollis...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145070/arsenic-forms-and-their-combinations-induce-differences-in-phenolic-accumulation-in-ulmus-laevis-pall
#2
Kinga Drzewiecka, Monika Gąsecka, Paweł Rutkowski, Zuzanna Magdziak, Piotr Goliński, Mirosław Mleczek
Total phenolics and the profile of phenolic acids and flavonoids were investigated in the roots and leaves of Ulmus laevis cultured on the medium with inorganic and organic arsenic - As(III), As(V) and DMA(V) at 0.06mM and their equimolar combinations. Further, the accumulation of salicylic acid (free and glucoside-bound) and lipid oxidation were assayed following a three-month long experiment. As treatment caused elevated production of phenolics, which was higher in photosynthetic tissue than in roots for all As forms and their combinations, and their overall content was correlated with the accumulation of organic As in roots and As(III) in leaves...
November 11, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29145067/role-of-thalamic-ventral-posterolateral-nucleus-histamine-h2-and-opiate-receptors-in-modulation-of-formalin-induced-muscle-pain-in-rats
#3
Hamid Ghasemi, Esmaeal Tamaddonfard, Farhad Soltanalinejad
BACKGROUND: Histamine and opiate systems contribute to supraspinal processing of pain. In the present study, we investigated the effects of microinjection of histamine and agonists and antagonists of histamine H2 and opiate receptors into the thalamic ventral posterolateral nucleus on muscle pain in rats. METHODS: The thalamic ventral posterolateral nuclei were bilaterally implanted with two guide cannulas. Muscle pain was induced by intramuscular injection of a diluted formalin solution (2...
May 8, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29144171/circadian-gene-methylation-in-rotating-shift-nurses-a-cross-sectional-study
#4
Edyta Reszka, Edyta Wieczorek, Monika Przybek, Ewa Jabłońska, Paweł Kałużny, Agnieszka Bukowska-Damska, Shanbeh Zienolddiny, Beata Pepłońska
Investigating the methylation status of the circadian genes may contribute to a better understanding of the shift work-related circadian disruption in individuals exposed to artificial light at night. In the present study, we determined the methylation status of the circadian genes associated with a shift work pattern among nurses and midwives participating in a cross-sectional study in Lodz, Poland. Quantitative methylation polymerase chain reaction assays were used to assess promoter CpG methylation in PER1, PER2, PER3, CRY1, CRY2, BMAL1, CLOCK, and NPAS2 in genomic DNA from whole blood of 347 women having a rotating-shift work schedule and 363 women working days only...
November 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29142618/melatonin-supplementation-lowers-oxidative-stress-and-regulates-adipokines-in-obese-patients-on-a-calorie-restricted-diet
#5
Karolina Szewczyk-Golec, Paweł Rajewski, Marcin Gackowski, Celestyna Mila-Kierzenkowska, Roland Wesołowski, Paweł Sutkowy, Marta Pawłowska, Alina Woźniak
Obesity is one of the major global health problems. Melatonin deficiency has been demonstrated to correlate with obesity. The aim of the study was to estimate the effect of melatonin on oxidative stress and adipokine levels in obese patients on a calorie-restricted diet. Thirty obese patients were supplemented with a daily dose of 10 mg of melatonin (n = 15) or placebo (n = 15) for 30 days with a calorie-restricted diet. Serum levels of melatonin, 4-hydroxynonenal (HNE), adiponectin, omentin-1, leptin, and resistin, as well as erythrocytic malondialdehyde (MDA) concentration and Zn/Cu-superoxide dismutase, catalase, and glutathione peroxidase (GPx) activities, were measured at baseline and after supplementation...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29142419/antipsoriatic-and-anti-inflammatory-studies-of-berberis-aristata-extract-loaded-nanovesicular-gels
#6
Nimisha, Dilshad Ali Rizvi, Zeeshan Fatima, Neema, Chanchal Deep Kaur
Objective: Novel nanovesicular gel of Berberis aristata extract was developed and evaluated for its anti-inflammatory and antipsoriatic activity. Materials and Methods: Transferosomes were prepared using soya phosphatidylcholine and edge activators (Tween 80, Span 80, and sodium deoxycholate) by a modified lipid film hydration technique using rotary evaporator and evaluated for various parameters. The quantification and standardization of extract have been carried out using its alkaloid content as berberine as biomarker...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141567/discovery-of-thiazole-based-bis-heterocyclic-system-for-anti-inflammatory-potential
#7
Amit S Tapkir, Sohan S Chitlange, Ritesh P Bhole
BACKGROUND: We have developed a new series of 36 substituted thiazole derivatives prepared via reaction of substituted benzothiazole-2-amine with substituted phenacyl bromide Objective: This study was aimed to develop and successfully evaluate anti-inflammatory activity of substituted thiazole derivatives. METHOD: A new series of 36 substituted thiazole derivatives was synthesized and derivatives were characterized by analytical and spectrometric methods like IR, MS, and 1H NMR...
November 14, 2017: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29141043/lateral-migration-of-electrospun-hydrogel-nanofilaments-in-an-oscillatory-flow
#8
Sylwia Pawłowska, Paweł Nakielski, Filippo Pierini, Izabela K Piechocka, Krzysztof Zembrzycki, Tomasz A Kowalewski
The recent progress in bioengineering has created great interest in the dynamics and manipulation of long, deformable macromolecules interacting with fluid flow. We report experimental data on the cross-flow migration, bending, and buckling of extremely deformable hydrogel nanofilaments conveyed by an oscillatory flow into a microchannel. The changes in migration velocity and filament orientation are related to the flow velocity and the filament's initial position, deformation, and length. The observed migration dynamics of hydrogel filaments qualitatively confirms the validity of the previously developed worm-like bead-chain hydrodynamic model...
2017: PloS One
https://www.readbyqxmd.com/read/29138091/longitudinal-electrophysiological-changes-after-cervical-hemi-contusion-spinal-cord-injury-in-rats
#9
Zucheng Huang, Rong Li, Junhao Liu, Zhiping Huang, Yong Hu, Xiaoliang Wu, Qingan Zhu
OBJECTIVE: To evaluate the longitudinal somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) characterization from acute to chronic injury following the cervical hemi-contusion spinal cord injury (SCI) in rats, and correlate the MEPs & SEPs to the behavioral outcomes. METHODS: Fifteen adult male Sprague-Dawley rats were subjected to the hemi-contusion spinal cord injury at C5. Forelimb MEPs & SEPs were applied to 5 animals before injury and 3h, 1d, 3d, 1w, 2w, 4w and 8w after injury respectively...
November 11, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29137946/distinct-environmental-enrichment-protocols-reduce-anxiety-but-differentially-modulate-pain-sensitivity-in-rats
#10
Louise Faggionato Kimura, Vânia Gomes de Moura Mattaraia, Gisele Picolo
Environmental enrichment (EE) can alter anxiety as well as perception of nociceptive stimuli, suggesting a relationship between well-being and analgesia. Considering that, we aimed to evaluate the influence of different EE types on anxiety and peripheral pain sensibility of male Wistar rats. Animals were submitted to two different types of EE: On the first one, animals were housed in standard size cages after weaning and received three different objects, one type per week, on a regular basis (simple EE - sEE)...
November 11, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29137170/design-synthesis-and-biological-activity-of-tetrahydrobenzo-4-5-thieno-2-3-d-pyrimidine-derivatives-as-anti-inflammatory-agents
#11
Yuan Zhang, Lu Luo, Chao Han, Handeng Lv, Di Chen, Guoliang Shen, Kaiqi Wu, Suwei Pan, Faqing Ye
We designed and synthesized 26 prototype compounds and studied their anti-inflammatory activity and underlying molecular mechanisms. The inhibitory effects of the compounds on the production of nitric oxide (NO), cytokines, inflammatory-related proteins, and mRNAs in lipopolysaccharide (LPS)-stimulated macrophages were determined by the Griess assay, Enzyme linked immunosorbent assay (ELISA), Western blot analysis, and Reverse transcription-Polymerase Chain Reaction (RT-PCR), respectively. Our results indicated that treatment with A2, A6 and B7 significantly inhibited the secretion of NO and inflammatory cytokines in RAW264...
November 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29136768/lipoxin-a4-protects-against-spinal-cord-injury-via-regulating-akt-nuclear-factor-erythroid-derived-2-like-2-heme-oxygenase-1-signaling
#12
Tan Lu, Xuejian Wu, Na Wei, Xiaotan Liu, Yingfeng Zhou, Chunfeng Shang, Yongzhuang Duan, Yuzhen Dong
Spinal cord injury (SCI) is a devastating physical trauma worldwide. The mechanisms of SCI are still not clear and the effective treatment is limited. Lipoxin A4 (LXA4) possesses anti-inflammatory and neuroprotective effects. The present study was designed to further evaluate the molecular mechanisms of LXA4-induced protective effects in a rat model of SCI. We found that LXA4 increased Basso, Beattie and Bresnahan (BBB) scores, increased mechanical paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) to a radiant heat, reduced the lesion volume, decreased Bax mRNA expression and increased Bcl-2 expression after SCI...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29136617/prognostic-factors-in-patients-with-an-implanted-pacemaker-after-80-years-of-age-in-a-4-year-follow-up
#13
Krystyna Krzemień-Wolska, Andrzej Tomasik, Celina Wojciechowska, Karolina Barańska-Pawełczak, Ewa Nowalany-Kozielska, Wojciech Jacheć
BACKGROUND: The controversy over electrotherapy for patients aged >80 years occurs already at the stage of qualification for this treatment type and concerns optimal device selection, the implantation strategy, and the overall benefit from pacemaker therapy. The group also has a considerable number of cardiovascular risk factors, and the data from the literature on the impact of the pacing mode on the remote prognosis of this group are ambiguous. OBJECTIVE: Assessment of the risk factors for death among patients with implanted pacemakers >80 years of age in a 4-year follow-up...
November 15, 2017: Gerontology
https://www.readbyqxmd.com/read/29135586/increased-hyperalgesia-and-proinflammatory-cytokines-in-the-spinal-cord-and-dorsal-root-ganglion-after-surgery-and-or-fentanyl-administration-in-rats
#14
Lu Chang, Fang Ye, Quehua Luo, Yuanxiang Tao, Haihua Shu
BACKGROUND: Perioperative fentanyl has been reported to induce hyperalgesia and increase postoperative pain. In this study, we tried to investigate behavioral hyperalgesia, the expression of proinflammatory cytokines, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), and the activation of microglia in the spinal cord and dorsal root ganglion (DRG) in a rat model of surgical plantar incision with or without perioperative fentanyl. METHODS: Four groups of rats (n = 32 for each group) were subcutaneously injected with fentanyl at 60 μg/kg or normal saline for 4 times with 15-minute intervals...
November 10, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29134679/prediction-of-protein-structure-with-the-coarse-grained-unres-force-field-assisted-by-small-x-ray-scattering-data-and-knowledge-based-information
#15
Agnieszka S Karczyńska, Magdalena A Mozolewska, Paweƚ Krupa, Artur Gieƚdoń, Adam Liwo, Cezary Czaplewski
A new approach to assisted protein-structure prediction has been proposed, which is based on running multiplexed replica exchange molecular dynamics simulations with the coarse-grained UNRES force field with restraints derived from knowledge-based models and distance distribution from small angle X-ray scattering (SAXS) measurements. The latter restraints are incorporated into the target function as a maximum-likelihood term that guides the shape of the simulated structures towards that defined by SAXS. The approach was first verified with the 1KOY protein, for which the distance distribution was calculated from the experimental structure, and subsequently used to predict the structures of 11 data-assisted targets in the CASP12 experiment...
November 14, 2017: Proteins
https://www.readbyqxmd.com/read/29133043/1-4-naphthoquinones-potently-inhibiting-p2x7-receptor-activity
#16
R X Faria, F H Oliveira, J P Salles, A S Oliveira, N L von Ranke, M L Bello, C R Rodrigues, H C Castro, A R Louvis, D L Martins, V F Ferreira
P2X7 receptor (P2X7R) is an ATP-gated ion-channel with potential therapeutic applications. In this study, we prepared and searched a series of 1,4-naphthoquinones derivatives to evaluate their antagonistic effect on both human and murine P2X7 receptors. We explored the structure-activity relationship and binding mode of the most active compounds using a molecular modeling approach. Biological analysis of this series (eight analogues and two compounds) revealed significant in vitro inhibition against both human and murine P2X7R...
October 23, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29131818/electrical-stimulus-artifact-cancellation-and-neural-spike-detection-on-large-multi-electrode-arrays
#17
Gonzalo E Mena, Lauren E Grosberg, Sasidhar Madugula, Paweł Hottowy, Alan Litke, John Cunningham, E J Chichilnisky, Liam Paninski
Simultaneous electrical stimulation and recording using multi-electrode arrays can provide a valuable technique for studying circuit connectivity and engineering neural interfaces. However, interpreting these measurements is challenging because the spike sorting process (identifying and segregating action potentials arising from different neurons) is greatly complicated by electrical stimulation artifacts across the array, which can exhibit complex and nonlinear waveforms, and overlap temporarily with evoked spikes...
November 13, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29131351/ion-recombination-and-polarity-correction-factors-for-a-plane-parallel-ionization-chamber-in-a-proton-scanning-beam
#18
Małgorzata Liszka, Liliana Stolarczyk, Magdalena Kłodowska, Anna Kozera, Dawid Krzempek, Natalia Mojżeszek, Anna Pędracka, Michael Patrick Russell Waligórski, Paweł Olko
PURPOSE: To evaluate the effect on charge collection in the ionization chamber (IC) in proton pencil beam scanning (PBS), where the local dose-rate may exceed the dose rates encountered in conventional MV therapy by up to 3 orders of magnitude. METHODS: We measured values of the ion recombination (ks ) and polarity (kpol ) correction factors in water, for a plane-parallel Markus TM23343 IC, using the cyclotron-based Proteus-235 therapy system with an active proton PBS of energies 30-230 MeV...
November 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/29131294/clinical-echocardiographic-and-pacing-parameters-affecting-atrial-fibrillation-burden-in-tachycardia-bradycardia-patients
#19
Jan Bohdan Ciszewski, Tomasz Chwyczko, Ilona Kowalik, Wojciech Majda, Michał Mirosław Farkowski, Agnieszka Jankowska, Anna Borowiec, Paweł Syska, Hanna Szwed, Mariusz Pytkowski
BACKGROUND: The influence of different factors on the atrial fibrillation (AF) development in the population of tachycardia bradycardia syndrome (TBS) patients remains unclear. There is no data examining such an impact of different right ventricular pacing percentage (RVp%) profiles. AIM: The purpose of the study was to evaluate the relationship between the AF burden (AFB) and different clinical, echocardiographic and pacing parameters in TBS patients. METHODS: We performed a prospective, one-year registry of TBS patients with documented AF referred to the dual-chamber pacemaker (DDD) implantation...
November 13, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/29130540/anti-inflammatory-and-analgesic-activities-of-cupressuflavone-from-cupressus-macrocarpa-impact-on-pro-inflammatory-mediators
#20
Eman Al-Sayed, Haidy A Gad, Mohamed El-Shazly, Mohamed M Abdel-Daim, Abdel Nasser Singab
Hit, Lead & Candidate Discovery Inflammation is a complex biological process that is generally occurs in response to pathological triggers. Both neurodegenerative diseases and cancer have been linked to inflammation. The analgesic and anti-inflammatory effects of cupressuflavone (CUF) isolated from Cupressus macrocarpa were examined. The analgesic effects of CUF (40, 80 and 160 mg/kg po) were assessed in the acetic acid-induced writhing and hot plate models in mice with diclofenac sodium as the reference standard (100 mg/kg)...
November 11, 2017: Drug Development Research
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